[Hub]/) : Traits : Blood Platelet Count : ← →

chr2:84,662,093-87,126,250

Best TWAS P=7.96e-20 · Best GWAS P=5.21e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Breast Mammary Tissue (Female)	TGOLN2	0.10	0.01	lasso	2	0.02	8.7e-02	-9.1	-9.1	8.0e-20	1.00	0.02	0.43	TRUE
37	GTEx	Skin Sun Exposed Lower leg	REEP1	0.09	0.00	enet	16	0.02	1.2e-02	5.8	7.0	1.8e-12	0.06	0.02	0.90	TRUE
28	GTEx	Lung	GNLY	0.41	0.15	lasso	7	0.15	1.9e-11	7.1	6.5	6.0e-11	0.07	1.00	0.00	TRUE
32	GTEx	Ovary	USP39	0.40	0.02	lasso	6	0.05	2.8e-02	2.8	-6.4	1.6e-10	0.09	0.07	0.06	TRUE
56	YFS	Blood	GGCX	0.25	0.08	bslmm	474	0.16	1.2e-50	5.4	5.3	1.1e-07	-0.17	1.00	0.00	TRUE
55	ROSMAP	Brain Pre-frontal Cortex	SH2D6	0.10	0.08	lasso	6	0.14	1.5e-17	7.4	9.1	9.4e-20	-0.74	0.02	0.98	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	CAPG	0.27	0.19	lasso	2	0.10	9.4e-04	-9.1	-9.0	1.5e-19	1.00	0.00	0.98	FALSE
44	GTEx	Thyroid	ELMOD3	0.10	0.01	enet	10	0.02	7.7e-03	-6.3	9.0	1.8e-19	-0.78	0.01	0.95	FALSE
41	GTEx	Testis	CAPG	0.49	0.48	enet	20	0.49	2.6e-24	-9.1	-8.8	9.9e-19	0.94	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CAPG	0.08	0.03	blup	43	0.08	2.0e-08	-7.0	-8.8	2.0e-18	0.66	0.08	0.92	FALSE
43	GTEx	Thyroid	CAPG	0.17	0.10	lasso	6	0.10	3.7e-08	7.9	-8.4	4.9e-17	0.56	0.74	0.25	FALSE
36	GTEx	Skin Sun Exposed Lower leg	CAPG	0.24	0.22	lasso	5	0.21	4.1e-17	8.4	-8.3	8.4e-17	0.60	0.64	0.36	FALSE
30	GTEx	Muscle Skeletal	CAPG	0.12	0.04	lasso	6	0.04	4.8e-05	-6.6	-7.9	2.1e-15	0.61	0.48	0.50	FALSE
39	GTEx	Skin Sun Exposed Lower leg	AC093162.5	0.08	0.05	lasso	3	0.06	5.0e-06	8.4	-7.9	2.3e-15	0.57	0.73	0.23	FALSE
24	GTEx	Esophagus Muscularis	CAPG	0.17	0.16	lasso	4	0.14	8.2e-09	-7.3	-7.8	4.5e-15	0.91	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	SH2D6	0.07	0.06	lasso	3	0.06	9.3e-08	-6.1	7.8	8.7e-15	-0.62	0.11	0.88	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH2D6	0.05	0.06	lasso	2	0.05	8.2e-11	-7.3	-7.6	3.8e-14	0.86	0.48	0.52	FALSE
23	GTEx	Esophagus Mucosa	TGOLN2	0.17	0.19	enet	15	0.18	3.0e-12	-6.9	-7.6	3.9e-14	0.61	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	TGOLN2	0.26	0.15	lasso	7	0.18	6.0e-15	-7.0	-7.5	4.3e-14	0.65	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	RETSAT	0.29	0.15	enet	27	0.17	3.5e-19	-6.3	7.5	5.1e-14	-0.71	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	SH2D6	0.12	0.09	enet	7	0.09	3.1e-10	-7.3	-7.5	5.8e-14	0.79	0.95	0.05	FALSE
46	GTEx	Thyroid	TGOLN2	0.09	0.04	lasso	3	0.07	8.7e-06	-6.3	-7.5	7.0e-14	0.70	0.22	0.69	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	TGOLN2	0.09	0.13	blup	64	0.13	7.6e-13	-7.0	-7.4	1.1e-13	0.47	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	TGOLN2	0.13	0.20	enet	10	0.22	3.1e-22	6.7	-7.3	2.1e-13	0.60	0.01	0.99	FALSE
29	GTEx	Lung	TGOLN2	0.07	0.04	enet	9	0.04	6.4e-04	6.7	-7.3	4.0e-13	0.64	0.50	0.48	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	CAPG	0.24	0.08	lasso	3	0.14	3.6e-05	-4.9	-7.2	6.6e-13	0.27	0.09	0.06	FALSE
51	NTR	Blood	RETSAT	0.07	0.09	enet	21	0.09	2.9e-28	-6.5	7.2	7.3e-13	-0.63	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Female)	TCF7L1	0.13	-0.01	enet	8	0.01	1.7e-01	-1.4	-7.1	1.0e-12	0.59	0.02	0.72	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TGOLN2	0.13	0.18	enet	18	0.20	1.5e-22	-6.6	-7.1	1.1e-12	0.55	0.03	0.97	FALSE
25	GTEx	Esophagus Muscularis	AC093162.5	0.14	0.09	lasso	2	0.06	1.3e-04	-7.1	7.1	1.2e-12	-0.57	0.56	0.12	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	CAPG	0.18	0.14	lasso	4	0.10	6.5e-06	7.9	-7.1	1.4e-12	0.46	0.84	0.08	FALSE
2	GTEx	Adipose Visceral Omentum	TGOLN2	0.18	0.06	lasso	5	0.06	7.0e-04	-6.3	-7.1	1.5e-12	0.63	0.07	0.81	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	CAPG	0.27	0.15	bslmm	456	0.23	1.4e-29	-9.2	-7.1	1.6e-12	0.74	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SH2D6	0.04	0.02	lasso	2	0.03	2.6e-03	-6.2	-7.0	2.3e-12	0.43	0.06	0.04	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RETSAT	0.07	0.04	blup	56	0.05	4.8e-03	-6.3	7.0	2.5e-12	-0.73	0.07	0.18	FALSE
49	GTEx	Whole Blood	AC093162.5	0.11	0.03	lasso	2	0.01	4.0e-02	-7.1	7.0	3.5e-12	-0.58	0.42	0.25	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TGOLN2	0.05	0.10	lasso	1	0.09	1.1e-10	-6.9	-6.9	4.7e-12	0.58	0.01	0.99	FALSE
31	GTEx	Nerve Tibial	AC093162.5	0.14	0.10	enet	11	0.07	1.6e-05	-6.5	6.9	5.0e-12	-0.57	0.97	0.01	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	TGOLN2	0.49	0.15	enet	50	0.32	3.0e-11	-4.9	-6.9	5.2e-12	0.52	0.16	0.79	FALSE
19	GTEx	Cells Transformed fibroblasts	TGOLN2	0.22	0.26	enet	15	0.27	2.4e-20	-6.9	-6.9	5.6e-12	0.59	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	TGOLN2	0.02	0.02	enet	9	0.02	7.1e-04	6.7	-6.9	5.9e-12	0.55	0.02	0.94	FALSE
86	The Cancer Genome Atlas	Rectum Adenocarcinoma	TGOLN2	0.31	0.19	enet	10	0.15	1.8e-04	6.7	-6.8	1.2e-11	0.53	0.03	0.93	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TGOLN2	0.09	0.09	lasso	9	0.08	2.8e-05	-6.6	-6.7	1.8e-11	0.55	0.02	0.97	FALSE
20	GTEx	Colon Transverse	TGOLN2	0.18	0.13	enet	16	0.12	2.8e-06	-7.0	-6.7	2.7e-11	0.53	0.89	0.08	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	TGOLN2	0.08	0.08	blup	64	0.12	2.0e-13	-7.0	-6.7	2.8e-11	0.50	0.02	0.98	FALSE
40	GTEx	Stomach	TGOLN2	0.20	0.11	enet	14	0.11	5.4e-06	-7.1	-6.6	3.4e-11	0.60	0.96	0.01	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TGOLN2	0.06	0.09	lasso	2	0.08	8.6e-10	-6.6	-6.6	4.0e-11	0.55	0.04	0.96	FALSE
1	GTEx	Adipose Subcutaneous	TGOLN2	0.07	0.09	lasso	2	0.08	6.7e-07	6.7	-6.6	5.5e-11	0.53	0.83	0.14	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	TGOLN2	0.05	0.10	lasso	5	0.11	5.5e-21	-7.0	-6.5	7.4e-11	0.61	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TGOLN2	0.18	0.16	lasso	6	0.16	3.5e-11	-6.6	-6.5	7.9e-11	0.56	0.03	0.97	FALSE
74	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SH2D6	0.21	0.08	lasso	6	0.18	1.2e-08	-2.3	-6.4	1.3e-10	0.75	0.00	0.99	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	TGOLN2	0.09	0.08	lasso	9	0.08	1.1e-06	-6.6	-6.4	1.4e-10	0.59	0.03	0.97	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	RETSAT	0.24	0.13	bslmm	442	0.17	7.3e-22	-6.3	6.4	2.0e-10	-0.46	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	CAPG	0.28	0.20	enet	13	0.24	5.8e-16	-6.1	-6.3	2.8e-10	0.37	0.96	0.04	FALSE
6	GTEx	Brain Cerebellum	REEP1	0.29	0.14	enet	22	0.15	3.0e-05	-5.0	6.3	3.2e-10	0.02	0.04	0.96	FALSE
62	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TGOLN2	0.15	0.17	enet	8	0.15	6.4e-08	-6.6	-6.3	3.2e-10	0.55	0.05	0.94	FALSE
87	The Cancer Genome Atlas	Soft Tissue Sarcoma	REEP1	0.05	0.07	lasso	4	0.05	8.1e-04	6.2	6.3	3.2e-10	0.06	0.01	0.96	FALSE
13	GTEx	Breast Mammary Tissue (Male)	TGOLN2	0.15	-0.01	lasso	1	0.00	3.8e-01	-6.3	-6.3	3.4e-10	0.67	0.04	0.18	FALSE
26	GTEx	Liver	TGOLN2	0.29	0.28	lasso	3	0.27	4.2e-08	-4.9	-6.3	3.5e-10	0.71	0.29	0.56	FALSE
47	GTEx	Thyroid	AC093162.5	0.23	0.19	enet	22	0.20	6.5e-15	-6.5	6.2	4.5e-10	-0.57	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	MAT2A	0.41	0.08	enet	40	0.15	4.5e-05	8.4	6.2	6.4e-10	-0.59	0.02	0.95	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAT2A	0.05	0.03	blup	37	0.03	5.3e-04	4.5	6.2	6.7e-10	-0.15	0.03	0.11	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TGOLN2	0.08	0.05	blup	64	0.08	4.2e-04	6.0	-6.1	8.6e-10	0.56	0.02	0.95	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	TGOLN2	0.27	0.18	enet	19	0.15	2.1e-08	-4.9	-6.1	1.1e-09	0.65	0.70	0.30	FALSE
21	GTEx	Colon Transverse	AC093162.5	0.20	0.01	lasso	4	0.05	1.6e-03	-7.1	6.1	1.3e-09	-0.48	0.50	0.08	FALSE
48	GTEx	Whole Blood	RETSAT	0.13	0.08	lasso	5	0.14	8.0e-13	-4.1	6.1	1.3e-09	-0.64	0.98	0.02	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH2D6	0.05	0.01	blup	44	0.02	1.1e-03	-7.3	-6.0	2.4e-09	0.67	0.02	0.49	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	TGOLN2	0.26	0.18	enet	14	0.15	5.1e-09	-6.9	-6.0	2.6e-09	0.55	0.01	0.99	FALSE
42	GTEx	Testis	REEP1	0.15	0.04	enet	37	0.02	4.3e-02	-5.0	5.9	2.8e-09	0.08	0.17	0.66	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	MRPL35	0.11	0.08	lasso	3	0.07	7.4e-08	5.9	5.9	3.3e-09	0.06	0.01	0.99	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	CAPG	0.23	0.02	enet	10	0.12	1.2e-04	-4.5	-5.9	3.8e-09	0.67	0.01	0.96	FALSE
3	GTEx	Adrenal Gland	MRPL35	0.19	0.10	enet	9	0.14	1.0e-05	-4.4	5.9	4.1e-09	0.05	0.08	0.84	FALSE
27	GTEx	Lung	RETSAT	0.17	0.08	enet	29	0.11	8.4e-09	-4.1	5.8	5.0e-09	-0.23	0.72	0.01	FALSE
57	YFS	Blood	RNF181	0.20	0.19	bslmm	474	0.20	4.4e-62	5.7	-5.7	9.6e-09	0.00	1.00	0.00	FALSE
12	GTEx	Brain Putamen basal ganglia	REEP1	0.20	0.18	lasso	7	0.18	5.0e-05	5.7	5.7	1.1e-08	0.08	0.04	0.88	FALSE
4	GTEx	Artery Tibial	CAPG	0.56	0.38	enet	38	0.43	1.7e-36	-4.8	-5.6	1.8e-08	0.56	1.00	0.00	FALSE
33	GTEx	Pancreas	TGOLN2	0.30	0.00	enet	36	0.07	7.3e-04	5.6	-5.6	1.9e-08	0.44	0.17	0.12	FALSE
18	GTEx	Cells Transformed fibroblasts	CAPG	0.26	0.13	lasso	8	0.20	1.1e-14	-7.3	-5.5	2.9e-08	0.69	0.51	0.49	FALSE
65	The Cancer Genome Atlas	Esophageal Carcinoma	TGOLN2	0.15	0.07	blup	64	0.14	3.1e-05	-6.9	-5.5	2.9e-08	0.51	0.02	0.94	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	GNLY	0.19	0.11	blup	56	0.14	6.5e-28	3.9	5.5	3.1e-08	-0.08	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	REEP1	0.16	0.17	blup	109	0.19	2.1e-19	6.0	5.5	3.4e-08	0.06	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MRPL35	0.04	0.02	blup	61	0.02	2.9e-02	4.7	5.5	4.5e-08	0.05	0.03	0.63	FALSE
89	The Cancer Genome Atlas	Testicular Germ Cell Tumors	REEP1	0.10	0.04	blup	109	0.07	2.0e-03	-4.1	5.4	5.7e-08	0.06	0.06	0.87	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	REEP1	0.11	0.12	lasso	11	0.14	3.7e-17	-4.4	5.3	9.1e-08	0.06	0.84	0.16	FALSE
7	GTEx	Brain Cerebellum	IMMT	0.26	0.16	enet	14	0.22	2.8e-07	-4.2	-5.3	1.0e-07	-0.04	0.74	0.03	FALSE
10	GTEx	Brain Hippocampus	REEP1	0.33	0.22	lasso	3	0.21	9.6e-06	-5.0	5.3	1.2e-07	0.10	0.06	0.89	FALSE
5	GTEx	Brain Caudate basal ganglia	REEP1	0.14	0.11	lasso	3	0.04	2.1e-02	4.9	5.3	1.3e-07	0.08	0.05	0.72	FALSE
45	GTEx	Thyroid	IMMT	0.11	0.09	lasso	13	0.11	6.9e-09	-5.0	-5.3	1.3e-07	-0.06	0.99	0.00	FALSE
9	GTEx	Brain Cortex	GGCX	0.38	0.17	enet	30	0.02	1.1e-01	3.2	5.2	2.3e-07	-0.09	0.56	0.03	FALSE
50	GTEx	Whole Blood	RP11-301O19.1	0.04	0.05	enet	20	0.04	5.4e-05	4.6	5.2	2.4e-07	0.04	0.71	0.24	FALSE