[Hub]/) : Traits : Blood Platelet Count :

chr2:84,662,093-87,126,250

Best TWAS P=7.96e-20 · Best GWAS P=5.21e-20 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TGOLN2 0.07 0.09 lasso 2 0.08 6.7e-07 6.7 -6.6 5.5e-11 0.53 0.83 0.14 FALSE
2 GTEx Adipose Visceral Omentum TGOLN2 0.18 0.06 lasso 5 0.06 7.0e-04 -6.3 -7.1 1.5e-12 0.63 0.07 0.81 FALSE
3 GTEx Adrenal Gland MRPL35 0.19 0.10 enet 9 0.14 1.0e-05 -4.4 5.9 4.1e-09 0.05 0.08 0.84 FALSE
4 GTEx Artery Tibial CAPG 0.56 0.38 enet 38 0.43 1.7e-36 -4.8 -5.6 1.8e-08 0.56 1.00 0.00 FALSE
5 GTEx Brain Caudate basal ganglia REEP1 0.14 0.11 lasso 3 0.04 2.1e-02 4.9 5.3 1.3e-07 0.08 0.05 0.72 FALSE
6 GTEx Brain Cerebellum REEP1 0.29 0.14 enet 22 0.15 3.0e-05 -5.0 6.3 3.2e-10 0.02 0.04 0.96 FALSE
7 GTEx Brain Cerebellum IMMT 0.26 0.16 enet 14 0.22 2.8e-07 -4.2 -5.3 1.0e-07 -0.04 0.74 0.03 FALSE
8 GTEx Brain Cerebellum MAT2A 0.41 0.08 enet 40 0.15 4.5e-05 8.4 6.2 6.4e-10 -0.59 0.02 0.95 FALSE
9 GTEx Brain Cortex GGCX 0.38 0.17 enet 30 0.02 1.1e-01 3.2 5.2 2.3e-07 -0.09 0.56 0.03 FALSE
10 GTEx Brain Hippocampus REEP1 0.33 0.22 lasso 3 0.21 9.6e-06 -5.0 5.3 1.2e-07 0.10 0.06 0.89 FALSE
11 GTEx Brain Nucleus accumbens basal ganglia CAPG 0.27 0.19 lasso 2 0.10 9.4e-04 -9.1 -9.0 1.5e-19 1.00 0.00 0.98 FALSE
12 GTEx Brain Putamen basal ganglia REEP1 0.20 0.18 lasso 7 0.18 5.0e-05 5.7 5.7 1.1e-08 0.08 0.04 0.88 FALSE
13 GTEx Breast Mammary Tissue (Male) TGOLN2 0.15 -0.01 lasso 1 0.00 3.8e-01 -6.3 -6.3 3.4e-10 0.67 0.04 0.18 FALSE
14 GTEx Breast Mammary Tissue (Female) TCF7L1 0.13 -0.01 enet 8 0.01 1.7e-01 -1.4 -7.1 1.0e-12 0.59 0.02 0.72 FALSE
15 GTEx Breast Mammary Tissue (Female) TGOLN2 0.10 0.01 lasso 2 0.02 8.7e-02 -9.1 -9.1 8.0e-20 1.00 0.02 0.43 TRUE
16 GTEx Cells EBV-transformed lymphocytes CAPG 0.23 0.02 enet 10 0.12 1.2e-04 -4.5 -5.9 3.8e-09 0.67 0.01 0.96 FALSE
17 GTEx Cells EBV-transformed lymphocytes TGOLN2 0.49 0.15 enet 50 0.32 3.0e-11 -4.9 -6.9 5.2e-12 0.52 0.16 0.79 FALSE
18 GTEx Cells Transformed fibroblasts CAPG 0.26 0.13 lasso 8 0.20 1.1e-14 -7.3 -5.5 2.9e-08 0.69 0.51 0.49 FALSE
19 GTEx Cells Transformed fibroblasts TGOLN2 0.22 0.26 enet 15 0.27 2.4e-20 -6.9 -6.9 5.6e-12 0.59 1.00 0.00 FALSE
20 GTEx Colon Transverse TGOLN2 0.18 0.13 enet 16 0.12 2.8e-06 -7.0 -6.7 2.7e-11 0.53 0.89 0.08 FALSE
21 GTEx Colon Transverse AC093162.5 0.20 0.01 lasso 4 0.05 1.6e-03 -7.1 6.1 1.3e-09 -0.48 0.50 0.08 FALSE
22 GTEx Esophagus Mucosa CAPG 0.28 0.20 enet 13 0.24 5.8e-16 -6.1 -6.3 2.8e-10 0.37 0.96 0.04 FALSE
23 GTEx Esophagus Mucosa TGOLN2 0.17 0.19 enet 15 0.18 3.0e-12 -6.9 -7.6 3.9e-14 0.61 1.00 0.00 FALSE
24 GTEx Esophagus Muscularis CAPG 0.17 0.16 lasso 4 0.14 8.2e-09 -7.3 -7.8 4.5e-15 0.91 0.01 0.99 FALSE
25 GTEx Esophagus Muscularis AC093162.5 0.14 0.09 lasso 2 0.06 1.3e-04 -7.1 7.1 1.2e-12 -0.57 0.56 0.12 FALSE
26 GTEx Liver TGOLN2 0.29 0.28 lasso 3 0.27 4.2e-08 -4.9 -6.3 3.5e-10 0.71 0.29 0.56 FALSE
27 GTEx Lung RETSAT 0.17 0.08 enet 29 0.11 8.4e-09 -4.1 5.8 5.0e-09 -0.23 0.72 0.01 FALSE
28 GTEx Lung GNLY 0.41 0.15 lasso 7 0.15 1.9e-11 7.1 6.5 6.0e-11 0.07 1.00 0.00 TRUE
29 GTEx Lung TGOLN2 0.07 0.04 enet 9 0.04 6.4e-04 6.7 -7.3 4.0e-13 0.64 0.50 0.48 FALSE
30 GTEx Muscle Skeletal CAPG 0.12 0.04 lasso 6 0.04 4.8e-05 -6.6 -7.9 2.1e-15 0.61 0.48 0.50 FALSE
31 GTEx Nerve Tibial AC093162.5 0.14 0.10 enet 11 0.07 1.6e-05 -6.5 6.9 5.0e-12 -0.57 0.97 0.01 FALSE
32 GTEx Ovary USP39 0.40 0.02 lasso 6 0.05 2.8e-02 2.8 -6.4 1.6e-10 0.09 0.07 0.06 TRUE
33 GTEx Pancreas TGOLN2 0.30 0.00 enet 36 0.07 7.3e-04 5.6 -5.6 1.9e-08 0.44 0.17 0.12 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic CAPG 0.18 0.14 lasso 4 0.10 6.5e-06 7.9 -7.1 1.4e-12 0.46 0.84 0.08 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic TGOLN2 0.27 0.18 enet 19 0.15 2.1e-08 -4.9 -6.1 1.1e-09 0.65 0.70 0.30 FALSE
36 GTEx Skin Sun Exposed Lower leg CAPG 0.24 0.22 lasso 5 0.21 4.1e-17 8.4 -8.3 8.4e-17 0.60 0.64 0.36 FALSE
37 GTEx Skin Sun Exposed Lower leg REEP1 0.09 0.00 enet 16 0.02 1.2e-02 5.8 7.0 1.8e-12 0.06 0.02 0.90 TRUE
38 GTEx Skin Sun Exposed Lower leg TGOLN2 0.26 0.15 lasso 7 0.18 6.0e-15 -7.0 -7.5 4.3e-14 0.65 1.00 0.00 FALSE
39 GTEx Skin Sun Exposed Lower leg AC093162.5 0.08 0.05 lasso 3 0.06 5.0e-06 8.4 -7.9 2.3e-15 0.57 0.73 0.23 FALSE
40 GTEx Stomach TGOLN2 0.20 0.11 enet 14 0.11 5.4e-06 -7.1 -6.6 3.4e-11 0.60 0.96 0.01 FALSE
41 GTEx Testis CAPG 0.49 0.48 enet 20 0.49 2.6e-24 -9.1 -8.8 9.9e-19 0.94 0.00 1.00 FALSE
42 GTEx Testis REEP1 0.15 0.04 enet 37 0.02 4.3e-02 -5.0 5.9 2.8e-09 0.08 0.17 0.66 FALSE
43 GTEx Thyroid CAPG 0.17 0.10 lasso 6 0.10 3.7e-08 7.9 -8.4 4.9e-17 0.56 0.74 0.25 FALSE
44 GTEx Thyroid ELMOD3 0.10 0.01 enet 10 0.02 7.7e-03 -6.3 9.0 1.8e-19 -0.78 0.01 0.95 FALSE
45 GTEx Thyroid IMMT 0.11 0.09 lasso 13 0.11 6.9e-09 -5.0 -5.3 1.3e-07 -0.06 0.99 0.00 FALSE
46 GTEx Thyroid TGOLN2 0.09 0.04 lasso 3 0.07 8.7e-06 -6.3 -7.5 7.0e-14 0.70 0.22 0.69 FALSE
47 GTEx Thyroid AC093162.5 0.23 0.19 enet 22 0.20 6.5e-15 -6.5 6.2 4.5e-10 -0.57 1.00 0.00 FALSE
48 GTEx Whole Blood RETSAT 0.13 0.08 lasso 5 0.14 8.0e-13 -4.1 6.1 1.3e-09 -0.64 0.98 0.02 FALSE
49 GTEx Whole Blood AC093162.5 0.11 0.03 lasso 2 0.01 4.0e-02 -7.1 7.0 3.5e-12 -0.58 0.42 0.25 FALSE
50 GTEx Whole Blood RP11-301O19.1 0.04 0.05 enet 20 0.04 5.4e-05 4.6 5.2 2.4e-07 0.04 0.71 0.24 FALSE
51 NTR Blood RETSAT 0.07 0.09 enet 21 0.09 2.9e-28 -6.5 7.2 7.3e-13 -0.63 1.00 0.00 FALSE
52 ROSMAP Brain Pre-frontal Cortex RETSAT 0.24 0.13 bslmm 442 0.17 7.3e-22 -6.3 6.4 2.0e-10 -0.46 1.00 0.00 FALSE
53 ROSMAP Brain Pre-frontal Cortex CAPG 0.27 0.15 bslmm 456 0.23 1.4e-29 -9.2 -7.1 1.6e-12 0.74 0.00 1.00 FALSE
54 ROSMAP Brain Pre-frontal Cortex REEP1 0.11 0.12 lasso 11 0.14 3.7e-17 -4.4 5.3 9.1e-08 0.06 0.84 0.16 FALSE
55 ROSMAP Brain Pre-frontal Cortex SH2D6 0.10 0.08 lasso 6 0.14 1.5e-17 7.4 9.1 9.4e-20 -0.74 0.02 0.98 FALSE
56 YFS Blood GGCX 0.25 0.08 bslmm 474 0.16 1.2e-50 5.4 5.3 1.1e-07 -0.17 1.00 0.00 TRUE
57 YFS Blood RNF181 0.20 0.19 bslmm 474 0.20 4.4e-62 5.7 -5.7 9.6e-09 0.00 1.00 0.00 FALSE
58 The Cancer Genome Atlas Bladder Urothelial Carcinoma SH2D6 0.04 0.02 lasso 2 0.03 2.6e-03 -6.2 -7.0 2.3e-12 0.43 0.06 0.04 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma GNLY 0.19 0.11 blup 56 0.14 6.5e-28 3.9 5.5 3.1e-08 -0.08 1.00 0.00 FALSE
60 The Cancer Genome Atlas Breast Invasive Carcinoma SH2D6 0.05 0.06 lasso 2 0.05 8.2e-11 -7.3 -7.6 3.8e-14 0.86 0.48 0.52 FALSE
61 The Cancer Genome Atlas Breast Invasive Carcinoma TGOLN2 0.05 0.10 lasso 5 0.11 5.5e-21 -7.0 -6.5 7.4e-11 0.61 0.02 0.98 FALSE
62 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TGOLN2 0.15 0.17 enet 8 0.15 6.4e-08 -6.6 -6.3 3.2e-10 0.55 0.05 0.94 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma TGOLN2 0.26 0.18 enet 14 0.15 5.1e-09 -6.9 -6.0 2.6e-09 0.55 0.01 0.99 FALSE
64 The Cancer Genome Atlas Esophageal Carcinoma CAPG 0.24 0.08 lasso 3 0.14 3.6e-05 -4.9 -7.2 6.6e-13 0.27 0.09 0.06 FALSE
65 The Cancer Genome Atlas Esophageal Carcinoma TGOLN2 0.15 0.07 blup 64 0.14 3.1e-05 -6.9 -5.5 2.9e-08 0.51 0.02 0.94 FALSE
66 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TGOLN2 0.13 0.18 enet 18 0.20 1.5e-22 -6.6 -7.1 1.1e-12 0.55 0.03 0.97 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TGOLN2 0.05 0.10 lasso 1 0.09 1.1e-10 -6.9 -6.9 4.7e-12 0.58 0.01 0.99 FALSE
68 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MRPL35 0.04 0.02 blup 61 0.02 2.9e-02 4.7 5.5 4.5e-08 0.05 0.03 0.63 FALSE
69 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TGOLN2 0.09 0.09 lasso 9 0.08 2.8e-05 -6.6 -6.7 1.8e-11 0.55 0.02 0.97 FALSE
70 The Cancer Genome Atlas Brain Lower Grade Glioma MAT2A 0.05 0.03 blup 37 0.03 5.3e-04 4.5 6.2 6.7e-10 -0.15 0.03 0.11 FALSE
71 The Cancer Genome Atlas Brain Lower Grade Glioma RETSAT 0.29 0.15 enet 27 0.17 3.5e-19 -6.3 7.5 5.1e-14 -0.71 1.00 0.00 FALSE
72 The Cancer Genome Atlas Brain Lower Grade Glioma SH2D6 0.07 0.06 lasso 3 0.06 9.3e-08 -6.1 7.8 8.7e-15 -0.62 0.11 0.88 FALSE
73 The Cancer Genome Atlas Brain Lower Grade Glioma TGOLN2 0.02 0.02 enet 9 0.02 7.1e-04 6.7 -6.9 5.9e-12 0.55 0.02 0.94 FALSE
74 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SH2D6 0.21 0.08 lasso 6 0.18 1.2e-08 -2.3 -6.4 1.3e-10 0.75 0.00 0.99 FALSE
75 The Cancer Genome Atlas Lung Adenocarcinoma SH2D6 0.12 0.09 enet 7 0.09 3.1e-10 -7.3 -7.5 5.8e-14 0.79 0.95 0.05 FALSE
76 The Cancer Genome Atlas Lung Adenocarcinoma TGOLN2 0.08 0.08 blup 64 0.12 2.0e-13 -7.0 -6.7 2.8e-11 0.50 0.02 0.98 FALSE
77 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TGOLN2 0.06 0.09 lasso 2 0.08 8.6e-10 -6.6 -6.6 4.0e-11 0.55 0.04 0.96 FALSE
78 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TGOLN2 0.18 0.16 lasso 6 0.16 3.5e-11 -6.6 -6.5 7.9e-11 0.56 0.03 0.97 FALSE
79 The Cancer Genome Atlas Pancreatic Adenocarcinoma RETSAT 0.07 0.04 blup 56 0.05 4.8e-03 -6.3 7.0 2.5e-12 -0.73 0.07 0.18 FALSE
80 The Cancer Genome Atlas Pancreatic Adenocarcinoma TGOLN2 0.08 0.05 blup 64 0.08 4.2e-04 6.0 -6.1 8.6e-10 0.56 0.02 0.95 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma CAPG 0.08 0.03 blup 43 0.08 2.0e-08 -7.0 -8.8 2.0e-18 0.66 0.08 0.92 FALSE
82 The Cancer Genome Atlas Prostate Adenocarcinoma MRPL35 0.11 0.08 lasso 3 0.07 7.4e-08 5.9 5.9 3.3e-09 0.06 0.01 0.99 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma REEP1 0.16 0.17 blup 109 0.19 2.1e-19 6.0 5.5 3.4e-08 0.06 0.02 0.98 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma SH2D6 0.05 0.01 blup 44 0.02 1.1e-03 -7.3 -6.0 2.4e-09 0.67 0.02 0.49 FALSE
85 The Cancer Genome Atlas Prostate Adenocarcinoma TGOLN2 0.13 0.20 enet 10 0.22 3.1e-22 6.7 -7.3 2.1e-13 0.60 0.01 0.99 FALSE
86 The Cancer Genome Atlas Rectum Adenocarcinoma TGOLN2 0.31 0.19 enet 10 0.15 1.8e-04 6.7 -6.8 1.2e-11 0.53 0.03 0.93 FALSE
87 The Cancer Genome Atlas Soft Tissue Sarcoma REEP1 0.05 0.07 lasso 4 0.05 8.1e-04 6.2 6.3 3.2e-10 0.06 0.01 0.96 FALSE
88 The Cancer Genome Atlas Stomach Adenocarcinoma TGOLN2 0.09 0.08 lasso 9 0.08 1.1e-06 -6.6 -6.4 1.4e-10 0.59 0.03 0.97 FALSE
89 The Cancer Genome Atlas Testicular Germ Cell Tumors REEP1 0.10 0.04 blup 109 0.07 2.0e-03 -4.1 5.4 5.7e-08 0.06 0.06 0.87 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma TGOLN2 0.09 0.13 blup 64 0.13 7.6e-13 -7.0 -7.4 1.1e-13 0.47 0.01 0.99 FALSE