[Hub]/) : Traits : Blood Platelet Count : ← →

chr2:71,706,697-75,815,249

Best TWAS P=8.22e-22 · Best GWAS P=8.7e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	MRPL53	0.09	0.12	enet	14	0.12	1.3e-14	9.297	-9.6	8.2e-22	-0.97	0.01	0.99	TRUE
15	GTEx	Brain Cerebellum	MOGS	0.21	0.02	lasso	6	0.07	5.0e-03	9.085	8.8	8.4e-19	0.92	0.07	0.84	TRUE
64	METSIM	Adipose	INO80B	0.10	0.08	lasso	13	0.08	1.9e-12	8.719	-8.3	1.1e-16	-0.94	0.02	0.98	TRUE
41	GTEx	Lung	LBX2	0.22	0.24	enet	7	0.22	4.0e-17	7.466	7.9	2.0e-15	0.91	0.85	0.15	TRUE
38	GTEx	Liver	MOGS	0.23	-0.01	enet	23	0.04	3.2e-02	7.865	7.9	3.0e-15	0.84	0.03	0.85	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CCDC142	0.06	0.00	enet	14	0.01	5.8e-02	-0.992	7.4	1.1e-13	0.28	0.05	0.13	TRUE
33	GTEx	Esophagus Muscularis	MOGS	0.20	0.10	lasso	5	0.17	2.4e-10	9.085	7.2	6.4e-13	0.83	0.05	0.95	TRUE
77	YFS	Blood	DGUOK	0.02	0.00	enet	16	0.01	5.4e-04	4.008	-6.4	1.5e-10	-0.14	0.05	0.02	TRUE
78	YFS	Blood	HTRA2	0.01	0.01	blup	345	0.01	2.6e-04	6.494	-6.1	1.1e-09	-0.78	0.61	0.26	TRUE
44	GTEx	Nerve Tibial	EXOC6B	0.15	0.03	lasso	7	0.06	3.0e-05	-4.619	5.4	6.0e-08	0.01	0.16	0.83	TRUE
25	GTEx	Colon Sigmoid	LBX2	0.28	0.11	enet	23	0.16	4.0e-06	4.571	5.2	1.8e-07	0.67	0.34	0.41	TRUE
47	GTEx	Skin Sun Exposed Lower leg	INO80B	0.04	0.03	lasso	3	0.02	7.5e-03	9.351	-9.3	1.6e-20	-1.00	0.02	0.97	FALSE
80	YFS	Blood	MRPL53	0.20	0.33	lasso	6	0.33	3.8e-111	9.265	-9.3	1.7e-20	-1.00	0.01	0.99	FALSE
36	GTEx	Heart Atrial Appendage	LBX2	0.13	0.03	lasso	3	0.02	5.5e-02	9.085	9.3	1.9e-20	0.94	0.05	0.62	FALSE
37	GTEx	Heart Atrial Appendage	LBX2-AS1	0.11	0.05	lasso	8	0.03	1.3e-02	9.085	9.2	4.5e-20	0.98	0.07	0.56	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	MOGS	0.02	0.02	blup	33	0.02	1.8e-03	9.213	9.1	7.2e-20	0.99	0.02	0.93	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	WDR54	0.05	0.04	lasso	4	0.04	2.1e-04	9.213	-9.1	8.9e-20	-0.98	0.01	0.95	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	MOGS	0.04	0.02	blup	33	0.01	6.5e-02	9.297	9.1	9.4e-20	0.98	0.01	0.91	FALSE
56	GTEx	Thyroid	LBX2-AS1	0.38	0.35	lasso	2	0.35	2.2e-27	9.085	9.1	1.0e-19	0.98	0.09	0.91	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL53	0.05	0.05	blup	32	0.04	1.3e-03	9.322	-9.1	1.1e-19	-0.99	0.01	0.98	FALSE
67	METSIM	Adipose	MRPL53	0.10	0.10	lasso	6	0.08	2.7e-12	9.213	-9.1	1.2e-19	-0.99	0.02	0.98	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	MOGS	0.12	0.16	lasso	6	0.16	1.1e-19	8.912	9.1	1.3e-19	0.99	0.04	0.96	FALSE
81	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC151534	0.03	0.02	blup	30	0.02	1.3e-02	8.265	9.0	1.7e-19	0.98	0.02	0.70	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	MRPL53	0.03	0.03	blup	32	0.04	2.3e-05	9.297	-8.9	3.7e-19	-0.98	0.02	0.98	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPL53	0.03	0.04	blup	32	0.04	1.2e-05	9.213	-8.9	4.1e-19	-0.98	0.02	0.98	FALSE
58	GTEx	Uterus	LBX2-AS1	0.22	0.15	enet	6	0.10	4.2e-03	9.085	8.9	4.3e-19	0.98	0.07	0.52	FALSE
28	GTEx	Colon Transverse	LBX2-AS1	0.09	0.05	lasso	3	0.05	1.4e-03	9.085	8.9	4.8e-19	0.97	0.10	0.85	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	TTC31	0.04	0.04	blup	33	0.04	9.0e-05	8.885	8.9	4.8e-19	0.99	0.02	0.98	FALSE
55	GTEx	Thyroid	LBX2	0.39	0.41	lasso	3	0.40	2.3e-32	9.085	8.9	5.3e-19	0.98	0.09	0.91	FALSE
32	GTEx	Esophagus Mucosa	LBX2-AS1	0.26	0.21	lasso	7	0.22	1.1e-14	9.085	8.9	5.6e-19	0.98	0.09	0.91	FALSE
31	GTEx	Esophagus Mucosa	LBX2	0.28	0.20	lasso	6	0.21	6.3e-14	9.085	8.9	7.7e-19	0.97	0.10	0.90	FALSE
59	GTEx	Vagina	LBX2	0.20	0.28	lasso	1	0.16	1.8e-04	8.831	8.8	1.0e-18	0.95	0.10	0.71	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	MRPL53	0.09	0.09	blup	32	0.09	2.2e-09	9.297	-8.8	1.2e-18	-0.96	0.01	0.99	FALSE
45	GTEx	Pituitary	MOGS	0.17	0.13	lasso	5	0.15	1.6e-04	9.213	8.7	2.5e-18	0.96	0.03	0.91	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL53	0.03	0.02	blup	32	0.03	2.4e-04	8.885	-8.7	2.6e-18	-0.98	0.02	0.96	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	WBP1	0.04	0.02	bslmm	362	0.04	1.6e-05	9.239	-8.7	3.6e-18	-0.92	0.02	0.98	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	LOC151534	0.04	0.05	blup	30	0.05	2.1e-05	9.085	8.6	5.8e-18	0.94	0.06	0.90	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MRPL53	0.05	0.08	lasso	3	0.08	4.8e-09	8.864	-8.6	5.9e-18	-0.96	0.02	0.98	FALSE
34	GTEx	Esophagus Muscularis	LBX2	0.13	0.07	enet	5	0.07	3.2e-05	8.912	8.6	6.3e-18	0.96	0.07	0.92	FALSE
42	GTEx	Lung	LBX2-AS1	0.14	0.14	lasso	4	0.16	2.7e-12	9.085	8.6	7.8e-18	0.95	0.15	0.85	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	INO80B	0.06	0.07	bslmm	363	0.06	3.5e-08	9.322	-8.6	9.7e-18	-0.97	0.02	0.98	FALSE
61	GTEx	Whole Blood	LBX2	0.12	0.12	lasso	5	0.11	1.1e-10	8.265	8.6	1.3e-17	0.92	0.53	0.47	FALSE
11	GTEx	Artery Coronary	MOGS	0.24	0.18	lasso	8	0.12	8.7e-05	8.912	8.5	1.4e-17	0.96	0.04	0.94	FALSE
62	GTEx	Whole Blood	LBX2-AS1	0.16	0.18	lasso	2	0.16	6.8e-15	8.265	8.5	1.7e-17	0.90	0.96	0.04	FALSE
27	GTEx	Colon Transverse	LBX2	0.11	0.13	enet	7	0.09	3.4e-05	9.085	8.5	2.1e-17	0.96	0.09	0.89	FALSE
60	GTEx	Vagina	LBX2-AS1	0.34	0.18	lasso	4	0.12	1.3e-03	8.831	8.4	2.9e-17	0.91	0.06	0.56	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AUP1	0.04	0.05	blup	23	0.06	1.3e-07	9.085	-8.4	3.0e-17	-0.96	0.02	0.98	FALSE
14	GTEx	Artery Tibial	LBX2-AS1	0.08	0.07	lasso	4	0.04	5.4e-04	9.085	8.4	4.0e-17	0.94	0.12	0.80	FALSE
10	GTEx	Artery Aorta	LBX2-AS1	0.07	0.04	lasso	3	0.01	5.3e-02	7.543	8.4	5.9e-17	0.93	0.07	0.74	FALSE
12	GTEx	Artery Tibial	MOGS	0.15	0.10	lasso	5	0.10	5.7e-08	8.831	8.3	7.5e-17	0.96	0.04	0.96	FALSE
39	GTEx	Lung	INO80B	0.06	0.01	lasso	5	0.00	1.2e-01	9.213	-8.3	8.2e-17	-0.94	0.04	0.91	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INO80B	0.02	0.01	blup	31	0.00	1.2e-01	7.466	-8.3	1.4e-16	-0.90	0.04	0.48	FALSE
5	GTEx	Adipose Visceral Omentum	INO80B	0.21	0.04	lasso	5	0.05	1.1e-03	8.864	-8.2	1.7e-16	-0.92	0.04	0.80	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC151534	0.03	0.02	blup	30	0.02	1.6e-03	9.297	8.2	2.6e-16	0.88	0.01	0.73	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	INO80B	0.09	0.06	lasso	4	0.04	4.3e-03	8.912	-8.1	4.0e-16	-0.93	0.10	0.75	FALSE
8	GTEx	Artery Aorta	MOGS	0.19	0.12	enet	14	0.16	3.1e-09	9.085	8.1	7.6e-16	0.88	0.03	0.97	FALSE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RTKN	0.02	0.01	blup	30	0.02	1.8e-03	7.303	8.0	1.1e-15	0.90	0.04	0.77	FALSE
16	GTEx	Brain Cortex	MOGS	0.15	0.07	lasso	3	0.07	4.4e-03	7.543	8.0	1.2e-15	0.89	0.08	0.39	FALSE
100	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MRPL53	0.13	0.09	blup	31	0.11	8.8e-05	6.113	-8.0	1.6e-15	-0.92	0.03	0.90	FALSE
24	GTEx	Colon Sigmoid	MOGS	0.32	0.21	lasso	6	0.14	1.1e-05	9.085	7.9	2.0e-15	0.95	0.05	0.94	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	C2orf81	0.03	0.01	blup	377	0.02	1.9e-03	8.742	-7.9	2.6e-15	-0.86	0.32	0.57	FALSE
30	GTEx	Esophagus Mucosa	MOGS	0.12	0.00	enet	15	0.04	1.5e-03	9.085	7.8	6.1e-15	0.85	0.06	0.92	FALSE
68	METSIM	Adipose	TTC31	0.02	0.00	blup	365	0.02	3.2e-04	8.265	7.7	1.1e-14	0.89	0.07	0.93	FALSE
29	GTEx	Esophagus Mucosa	INO80B	0.20	0.08	lasso	4	0.08	3.2e-06	5.136	-7.7	1.3e-14	-0.90	0.07	0.93	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	LBX2-AS1	0.04	0.03	bslmm	355	0.02	4.5e-04	7.739	7.7	1.4e-14	0.77	0.22	0.60	FALSE
94	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WDR54	0.04	0.00	lasso	4	0.02	1.7e-02	7.095	-7.7	2.0e-14	-0.81	0.01	0.73	FALSE
106	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C2orf81	0.11	0.05	blup	32	0.06	7.8e-03	6.594	-7.6	2.5e-14	-0.87	0.02	0.47	FALSE
88	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC151534	0.08	0.01	blup	30	0.06	1.9e-04	9.213	7.5	5.8e-14	0.93	0.02	0.91	FALSE
35	GTEx	Esophagus Muscularis	WBP1	0.12	0.01	lasso	1	0.00	2.0e-01	7.494	-7.5	6.7e-14	-0.84	0.06	0.37	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	C2orf81	0.03	0.01	lasso	5	0.01	1.1e-02	7.095	-7.5	8.8e-14	-0.77	0.02	0.75	FALSE
57	GTEx	Uterus	LBX2	0.26	0.09	lasso	3	0.06	2.1e-02	7.494	7.4	1.4e-13	0.84	0.07	0.34	FALSE
13	GTEx	Artery Tibial	LBX2	0.13	0.05	lasso	8	0.05	1.4e-04	7.466	7.4	1.5e-13	0.87	0.28	0.68	FALSE
4	GTEx	Adipose Subcutaneous	INO80B	0.08	0.02	lasso	5	0.03	1.5e-03	9.213	-7.3	3.5e-13	-0.90	0.03	0.95	FALSE
9	GTEx	Artery Aorta	TTC31	0.07	0.00	lasso	2	0.01	1.4e-01	6.113	7.2	6.2e-13	0.71	0.05	0.60	FALSE
53	GTEx	Thyroid	INO80B	0.10	0.06	enet	20	0.07	3.7e-06	4.788	-7.1	1.2e-12	-0.76	0.05	0.95	FALSE
20	GTEx	Breast Mammary Tissue (Female)	MOGS	0.18	0.07	lasso	4	0.06	9.0e-03	6.113	7.0	2.5e-12	0.81	0.09	0.57	FALSE
17	GTEx	Breast Mammary Tissue	MOGS	0.15	0.06	lasso	4	0.09	1.7e-05	3.678	6.9	6.1e-12	0.82	0.08	0.90	FALSE
26	GTEx	Colon Transverse	MOGS	0.13	0.01	enet	14	0.05	2.6e-03	8.742	6.8	7.2e-12	0.84	0.04	0.88	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LBX2	0.12	0.04	blup	31	0.03	7.4e-03	9.085	6.8	9.7e-12	0.85	0.03	0.75	FALSE
43	GTEx	Nerve Tibial	MOGS	0.23	0.03	lasso	8	0.07	1.4e-05	8.777	6.7	1.6e-11	0.81	0.03	0.97	FALSE
23	GTEx	Cells Transformed fibroblasts	CCDC142	0.07	0.00	enet	10	0.00	4.6e-01	7.494	-6.5	9.1e-11	-0.78	0.05	0.19	FALSE
40	GTEx	Lung	MOGS	0.14	0.03	enet	22	0.04	2.3e-04	3.475	6.4	1.5e-10	0.70	0.04	0.94	FALSE
79	YFS	Blood	INO80B	0.02	0.01	blup	349	0.01	9.0e-05	8.831	-6.4	1.5e-10	-0.82	0.04	0.93	FALSE
54	GTEx	Thyroid	MOGS	0.21	0.08	lasso	5	0.19	3.4e-14	-0.031	6.3	2.8e-10	0.75	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BOLA3	0.03	0.02	blup	46	0.01	1.7e-02	5.477	-6.2	4.9e-10	-0.10	0.01	0.88	FALSE
50	GTEx	Stomach	FNBP1P1	0.40	0.18	enet	8	0.30	1.3e-14	5.477	6.1	8.9e-10	0.11	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MRPL53	0.15	0.00	enet	15	0.04	3.9e-03	8.864	-6.1	9.2e-10	-0.62	0.01	0.49	FALSE
7	GTEx	Artery Aorta	INO80B	0.15	0.01	enet	19	0.08	2.6e-05	6.162	-6.1	1.1e-09	-0.48	0.15	0.47	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	MGC10955	0.58	0.49	lasso	8	0.51	2.0e-76	5.861	6.0	1.5e-09	0.08	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	MOGS	0.16	0.02	enet	12	0.02	2.7e-02	3.908	6.0	2.1e-09	0.78	0.08	0.72	FALSE
70	NTR	Blood	NAT8B	0.02	0.00	bslmm	343	0.00	5.7e-02	-2.922	-6.0	2.5e-09	-0.04	0.22	0.29	FALSE
95	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DCTN1	0.21	0.00	enet	9	0.03	3.0e-02	7.494	-5.9	3.0e-09	-0.63	0.01	0.44	FALSE
65	METSIM	Adipose	MGC10955	0.32	0.23	lasso	7	0.24	3.7e-36	5.840	5.9	3.9e-09	0.07	1.00	0.00	FALSE
48	GTEx	Skin Sun Exposed Lower leg	MOGS	0.12	0.06	lasso	4	0.07	1.3e-06	-0.031	5.8	5.1e-09	0.68	0.11	0.76	FALSE
66	METSIM	Adipose	MOGS	0.11	0.04	bslmm	366	0.10	1.7e-14	8.912	5.8	5.9e-09	0.71	0.02	0.98	FALSE
63	METSIM	Adipose	C2orf81	0.02	0.02	bslmm	374	0.01	2.5e-02	7.494	5.8	6.7e-09	0.84	0.08	0.84	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SEMA4F	0.06	0.00	blup	400	0.01	1.5e-02	3.836	5.8	9.1e-09	0.62	0.13	0.35	FALSE
19	GTEx	Breast Mammary Tissue (Male)	MOGS	0.14	0.06	lasso	3	0.06	1.7e-02	3.678	5.7	1.2e-08	0.73	0.04	0.47	FALSE
18	GTEx	Breast Mammary Tissue	FNBP1P1	0.39	0.13	enet	19	0.17	5.3e-09	5.477	5.7	1.5e-08	0.06	1.00	0.00	FALSE
52	GTEx	Testis	FNBP1P1	0.33	0.27	lasso	5	0.24	8.9e-11	5.477	5.7	1.5e-08	0.08	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue (Female)	FNBP1P1	0.22	0.21	lasso	2	0.10	4.9e-04	5.477	5.5	3.1e-08	0.07	0.36	0.04	FALSE
69	NTR	Blood	HK2	0.03	0.00	bslmm	460	0.01	1.5e-03	1.990	5.5	3.3e-08	0.21	0.16	0.02	FALSE
49	GTEx	Skin Sun Exposed Lower leg	FNBP1P1	0.46	0.23	lasso	7	0.29	5.6e-24	5.477	5.3	9.1e-08	0.07	1.00	0.00	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	FNBP1P1	0.69	0.33	enet	22	0.46	7.1e-17	5.741	5.3	1.2e-07	0.07	1.00	0.00	FALSE
51	GTEx	Testis	INO80B	0.09	0.01	enet	7	0.01	1.7e-01	6.350	-5.3	1.2e-07	-0.75	0.04	0.79	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	EXOC6B	0.04	0.02	lasso	6	0.02	7.0e-03	-5.302	5.2	1.6e-07	-0.06	0.04	0.85	FALSE