Best TWAS P=7.75e-12 · Best GWAS P=1.46e-24 conditioned to 0.877
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | ITGA9 | 0.39 | 0.18 | lasso | 5 | 0.21 | 8.8e-07 | -6.2 | 5.9 | 3.4e-09 | 0.03 | 0.01 | 0.96 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | CSRNP1 | 0.12 | 0.02 | lasso | 4 | 0.02 | 6.0e-03 | 4.2 | -6.8 | 7.8e-12 | -0.47 | 0.24 | 0.32 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SNORA62 | 0.14 | 0.04 | lasso | 5 | 0.02 | 1.5e-02 | 4.3 | 6.8 | 1.1e-11 | 0.45 | 0.06 | 0.79 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | SNORA6 | 0.09 | 0.02 | enet | 10 | 0.03 | 1.2e-03 | 3.6 | -5.2 | 1.6e-07 | -0.40 | 0.46 | 0.35 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TTC21A | 0.21 | 0.10 | blup | 460 | 0.16 | 2.0e-20 | 4.2 | 5.2 | 2.0e-07 | 0.46 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TRANK1 | 0.02 | 0.04 | lasso | 2 | 0.04 | 5.4e-05 | -5.2 | 5.2 | 1.8e-07 | 0.04 | 0.01 | 0.96 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | SCN11A | 0.02 | 0.01 | blup | 77 | 0.02 | 3.6e-03 | 4.2 | 6.5 | 6.9e-11 | 0.57 | 0.03 | 0.60 | TRUE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SCN11A | 0.07 | 0.03 | blup | 79 | 0.05 | 4.8e-04 | 6.5 | 6.6 | 3.5e-11 | 0.63 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCN11A | 0.05 | 0.03 | blup | 77 | 0.04 | 2.5e-05 | 3.9 | 5.7 | 9.3e-09 | 0.56 | 0.02 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SCN11A | 0.11 | 0.07 | blup | 77 | 0.07 | 9.4e-08 | 4.2 | 5.8 | 8.6e-09 | 0.49 | 0.89 | 0.10 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR48 | 0.07 | 0.00 | blup | 66 | 0.01 | 1.3e-02 | -0.7 | 5.9 | 4.1e-09 | 0.51 | 0.02 | 0.27 | TRUE |