TWAS hub - SCN11A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1380	0.0290	1.1e-16	0.168	0.155	0.176	0.177	0.193	6.3e-20	2.0e-18	5.8e-21	5.5e-21	5.4e-23
2	ROSMAP	Brain Pre-frontal Cortex	0.1710	0.0346	0.0e+00	0.167	0.153	0.155	0.167	0.167	5.9e-21	3.8e-19	1.8e-19	6.7e-21	6.1e-21
3	TCGA	Brain Lower Grade Glioma	0.0908	0.0357	1.2e-10	0.052	0.089	0.094	NA	0.080	1.3e-06	2.6e-10	8.5e-11	NA	2.0e-09
4	TCGA	Lung Adenocarcinoma	0.0230	0.0134	8.6e-03	0.006	0.017	0.011	NA	0.007	6.2e-02	3.6e-03	1.7e-02	NA	4.3e-02
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.0710	0.0350	2.4e-04	0.033	0.045	0.035	NA	0.045	2.5e-03	4.8e-04	2.0e-03	NA	5.2e-04
6	TCGA	Prostate Adenocarcinoma	0.0512	0.0242	3.6e-05	0.034	0.043	0.022	NA	0.041	1.8e-04	2.5e-05	1.9e-03	NA	4.0e-05
7	TCGA	Thyroid Carcinoma	0.1060	0.0450	7.0e-08	0.074	0.075	0.049	NA	0.067	1.0e-07	9.4e-08	1.6e-05	NA	4.1e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Supplements: Glucosamine	8.9	11.6	14.0	-3.7	-3.3	-3.5	-3.2	-3.3	-3.2	-3.5
Supplements: Vitamin C	8.5	10.1	19.9	-4.2	-4.5	-3.4	-1.9	-1.6	-2.0	-3.3
Alcohol usually taken with meals	5.3	8.6	13.8	-2.8	-3.2	-3.7	-1.7	-2.8	-3.2	-2.8
Age at first live birth	5.2	9.3	12.2	-3.3	-3.5	-3.5	-2.3	-2.7	-2.8	-3.1
Father’s age at death	4.7	6.3	7.5	-2.7	-2.6	-2.7	-2.2	-2.7	-2.6	-1.9
Hearing difficulty/problems: Yes	4.4	6.7	8.2	-2.9	-2.7	-2.5	-2.3	-2.7	-2.5	-2.4
Maternal smoking around birth	4.4	6.3	7.9	2.8	2.8	2.3	2.4	2.0	2.5	2.7
Headache pain in last month	3.6	6.2	9.0	3.0	2.9	2.5	1.7	2.2	2.2	2.7
Breast cancer (self-reported)	3.5	4.2	5.7	-2.2	-2.4	-1.9	-1.9	-1.6	-1.8	-2.4
Hand grip strength (left)	3.3	8.8	15.1	-1.6	-1.8	-2.2	-3.3	-3.9	-3.7	-3.4
Eye problems/disorders: Diabetes related eye disease	3.3	3.6	5.6	1.9	1.5	1.4	2.2	2.0	1.8	2.4
Mouth/teeth dental problems: Dentures	3.3	5.6	8.4	2.4	2.6	2.9	1.6	2.1	2.1	2.6
Age at last live birth	3.3	4.8	5.5	-2.2	-2.1	-2.1	-2.3	-2.3	-2.3	-2.1
Osteoporosis (self-reported)	3.3	4.0	6.8	-1.7	-1.4	-1.5	-2.3	-2.6	-2.6	-1.6
Medication: Lansoprazole	3.2	3.6	6.8	1.2	1.0	1.2	2.6	2.0	2.1	2.5
Angina	3.1	4.1	6.6	-2.4	-2.2	-2.6	-1.9	-1.5	-0.9	-2.1
Financial situation satisfaction	3.1	3.8	6.2	1.7	1.4	1.8	2.1	2.5	2.2	1.7
Qualifications: A levels/AS levels or equivalent	3.0	6.7	10.6	-3.0	-3.3	-2.8	-1.7	-1.9	-2.2	-2.8
Medication: Amlodipine	3.0	4.2	6.6	1.9	2.0	1.6	2.4	1.6	1.9	2.6
Medication: Ibuprofen	3.0	3.6	6.2	1.4	1.4	1.8	2.5	2.1	1.9	1.9
Angina (self-reported)	2.9	3.8	6.5	-2.3	-2.2	-2.5	-1.9	-1.5	-0.8	-1.9
Current tobacco smoking	2.8	4.5	8.9	2.4	2.9	3.0	0.4	1.6	1.8	1.7
Leg fat percentage (right)	2.8	10.0	12.7	2.8	3.2	3.0	2.4	3.5	3.6	3.5
Exposure to tobacco smoke outside home	2.8	3.8	7.4	2.7	2.3	2.2	1.3	1.2	1.2	2.1
Financial difficulties in last 2 years	2.7	3.6	6.0	1.7	1.4	2.2	1.7	2.4	2.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.6	7.2	-2.3	-2.5	-2.1	-2.0	-2.7	-2.5	-2.3
Lung FVC	2.6	13.2	18.3	-3.2	-3.0	-2.7	-4.3	-4.3	-4.1	-3.6
Mineral and other dietary supplements	2.6	3.5	8.1	1.2	1.0	1.4	2.4	1.6	1.8	2.8
Serious illness, injury or assault to yourself	2.5	3.0	4.3	-1.5	-1.8	-2.1	-1.2	-1.8	-1.9	-1.7
Arm fat percentage (left)	2.5	9.9	12.6	3.1	3.2	3.0	2.3	3.5	3.6	3.2
Average weekly red wine intake	2.5	3.7	5.7	-1.4	-1.5	-2.4	-1.6	-2.1	-2.2	-2.2
Tinnitus: Yes, now most or all of the time	2.5	2.9	5.6	-1.7	-1.6	-1.7	-1.6	-1.3	-1.6	-2.4
Supplements: Zinc	2.4	2.6	6.1	-1.9	-1.7	-1.3	-1.8	-0.5	-0.6	-2.5
Exposure to tobacco smoke at home	2.4	2.7	5.1	2.1	2.2	1.6	0.6	1.3	1.7	1.4
Body fat percentage	2.4	9.5	12.3	2.8	3.0	2.8	2.5	3.5	3.5	3.3
Medication: Paracetamol	2.4	3.7	5.1	1.6	1.6	1.7	1.9	2.0	2.2	2.3
Medication: Atenolol	2.3	2.8	5.5	2.1	2.0	2.4	0.8	0.9	1.4	1.6
Arm fat percentage (right)	2.3	8.9	11.4	3.0	3.1	2.9	2.0	3.4	3.3	3.0
Ever smoked	2.3	4.0	5.0	2.0	1.7	1.8	2.1	2.2	2.2	2.1
Blood White Count	2.2	16.6	28.2	3.4	2.6	3.4	4.7	4.6	3.9	5.3
Vitamin and mineral supplements	2.2	3.0	5.4	1.7	1.8	1.7	1.7	1.2	1.5	2.3
Qualifications: None of the above	2.2	4.8	6.9	2.2	2.3	2.3	1.7	1.8	2.3	2.6
Ever highly irritable/argumentative for 2 days	2.2	2.7	5.0	1.1	1.1	1.6	2.0	1.2	1.8	2.2
Smoking status: Current	2.2	3.4	6.9	2.0	2.5	2.6	0.4	1.4	1.6	1.5
Leg fat percentage (left)	2.2	7.9	11.0	2.5	2.8	2.6	2.0	3.1	3.3	3.1
Blood Platelet Count	2.1	24.3	43.8	2.0	1.9	3.2	6.5	6.6	5.7	5.8
Trunk fat percentage	2.1	8.6	11.0	2.7	2.8	2.5	2.4	3.3	3.3	3.2
Wheeze or whistling in the chest in last year	2.1	3.8	4.5	-1.8	-1.8	-1.9	-2.0	-2.0	-2.1	-2.0
Townsend deprivation index at recruitment	2.0	2.8	4.0	2.0	1.6	1.7	1.9	1.1	1.3	2.0
Had major operations	1.9	2.2	3.2	-1.3	-1.1	-1.4	-1.1	-1.8	-1.7	-1.8
Arm fat mass (left)	1.9	7.8	10.3	3.0	3.2	3.0	1.6	2.8	2.9	2.8
Average weekly beer plus cider intake	1.9	2.7	4.0	1.7	2.0	1.5	1.3	1.4	1.9	1.7
Ulcerative Colitis	1.8	2.5	4.8	-0.9	-0.9	-1.5	-1.9	-2.2	-1.8	-1.4
Hand grip strength (right)	1.8	4.9	8.0	-1.6	-2.0	-1.8	-1.9	-2.8	-2.8	-2.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	4.9	0.9	0.7	1.3	2.2	2.1	1.5	1.1
Lung cancer (father)	1.8	2.1	3.7	1.4	1.8	1.6	0.3	1.9	1.6	0.7
Illnesses of mother	1.8	2.2	4.0	1.4	1.5	1.3	2.0	0.6	1.0	2.0
Medication for pain relief, constipation, heartburn	1.8	3.1	5.3	-1.8	-1.5	-1.3	-1.6	-2.3	-2.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.4	-1.5	-1.8	-1.8	-0.4	-0.5	-1.3	-2.1
Whole body fat mass	1.8	7.6	9.0	2.8	3.0	2.8	1.8	2.9	3.0	2.8
Trunk fat mass	1.7	7.2	8.4	2.8	2.9	2.6	1.9	2.8	2.9	2.7
Leg fat mass (right)	1.7	6.5	8.3	2.6	2.9	2.7	1.6	2.6	2.7	2.6
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.5	-0.6	-0.4	-1.1	-2.1	-1.8	-1.5	-1.6
Past tobacco smoking	1.6	3.0	4.5	-1.8	-1.5	-1.2	-2.1	-1.7	-1.9	-1.8
Arm fat mass (right)	1.6	6.5	9.2	2.9	3.0	2.8	1.2	2.5	2.6	2.5
High blood pressure (siblings)	1.6	2.4	5.0	-1.6	-1.5	-2.2	-1.0	-1.6	-1.3	-1.3
Qualifications: College or University degree	1.6	5.1	6.2	-2.4	-2.5	-2.2	-1.7	-2.1	-2.3	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	3.7	0.9	0.5	1.1	1.6	1.3	1.4	1.9
Illnesses of father: None of the above (group 1)	1.6	2.0	3.2	1.0	1.3	1.8	0.6	1.7	1.8	1.2
Ever taken oral contraceptive pill	1.6	1.8	3.6	1.9	1.4	1.1	1.5	1.3	1.0	1.1
Coronary Artery Disease (CAD)	1.5	1.8	3.1	1.8	1.3	1.6	1.1	1.1	1.2	1.3
Time employed in main current job	1.5	1.8	2.6	-1.4	-1.0	-1.1	-1.6	-1.1	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	8.5	-1.4	-1.9	-1.2	-2.4	-2.9	-2.9	-2.2
Loud music exposure frequency	1.5	1.6	4.0	-1.9	-2.0	-1.1	-0.8	-1.1	-0.7	-0.6
Medication for hormone replacement therapy	1.4	1.6	2.1	-1.3	-1.1	-1.4	-1.2	-1.3	-1.0	-1.4
Body mass index (BMI)	1.4	5.8	8.8	2.7	3.0	2.5	1.2	2.1	2.6	2.4
Loneliness, isolation	1.4	2.0	4.5	1.6	1.9	2.1	0.4	1.0	1.0	1.1
Fed-up feelings	1.3	2.4	5.5	2.3	2.1	1.7	0.8	0.7	1.0	1.6
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	-1.7	-1.3	-1.3	-1.2	-1.2	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.7	-1.8	-2.2	-1.5	0.7	-0.1	-0.0	-0.3
Hypertension (Self-reported)	1.3	3.6	6.1	2.1	2.5	2.2	0.9	1.4	1.5	2.2
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-1.6	-1.4	-1.8	-0.5	-1.1	-1.0	-0.7
Ulcerative Colitis (UC)	1.2	2.3	5.1	-0.7	-0.3	-1.0	-2.1	-2.3	-1.7	-1.4
Smoking Status	1.2	2.8	5.1	2.0	2.2	2.1	0.8	1.1	1.4	1.5
Medication: Metformin	1.2	1.6	2.3	1.5	1.3	0.8	1.4	1.3	1.0	1.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.3	1.5	1.4	1.5	0.2	0.4	0.9	1.1
High blood pressure (mother)	1.2	1.6	2.6	-1.1	-1.5	-0.7	-1.3	-1.1	-1.3	-1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.1	-0.5	-0.9	-0.8	-0.8	-1.6	-2.0	-1.5
Chest pain or discomfort	1.2	1.7	3.1	-1.5	-1.6	-1.8	-0.8	-1.2	-0.9	-1.2
Smoking status: Previous	1.2	1.7	3.6	1.4	1.0	0.7	1.9	1.2	1.3	1.4
Medication: Atorvastatin	1.2	1.5	4.0	-0.9	-0.6	-0.6	-2.0	-1.6	-1.2	-1.0
Leg fat mass (left)	1.2	4.9	6.7	2.3	2.6	2.4	1.1	2.2	2.4	2.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.9	2.0	1.6	1.0	1.4	0.8	0.9	1.9
Multivitamins +/- minerals	1.1	1.4	2.8	-0.7	-0.8	-0.8	-1.5	-1.0	-1.3	-1.7
Neck or shoulder pain in last month	1.1	1.5	4.3	-0.5	-0.0	-0.6	-2.1	-1.8	-1.1	-1.1
Alcohol intake frequency.	1.1	2.6	3.7	1.9	1.6	1.9	1.3	1.6	1.2	1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.6	0.8	0.8	0.8	1.4	1.3	1.6	1.3
Medication: Aspirin	1.1	1.4	3.0	1.7	1.5	0.9	0.9	1.0	1.2	0.9
Medication: Lisinopril	1.1	1.4	2.7	-0.9	-0.6	-1.2	-1.4	-1.6	-1.6	-0.8
HDL Cholesterol	1.0	1.7	4.5	-1.9	-1.5	-2.1	-0.7	-0.4	-0.5	-0.8
Rheumatoid Arthritis	1.0	1.4	3.5	1.9	1.7	1.5	-0.2	0.2	0.2	0.9
Blood Red Count	1.0	9.9	12.5	3.1	2.9	2.6	3.5	3.4	3.1	3.3
High blood pressure	1.0	2.8	4.5	1.9	2.1	1.8	0.9	1.2	1.2	2.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	6.9	-0.9	-1.5	-0.8	-1.8	-2.6	-2.5	-1.5
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	1.4	1.6	0.7	0.7	0.5	0.8	1.5
Pulse wave peak to peak time	1.0	1.2	2.5	-1.3	-1.4	-0.6	-0.9	-0.7	-0.9	-1.6
Number of full sisters	1.0	1.2	2.0	1.1	1.0	0.9	0.9	1.1	0.9	1.4
Alcohol drinker status: Never	1.0	1.2	1.6	1.1	1.0	1.2	1.1	1.2	0.9	1.2
Triglycerides	0.9	1.4	2.1	0.9	1.1	1.3	1.2	1.4	1.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.8	1.0	1.1	1.1	0.8	0.8	0.9	1.3
Waist circumference	0.9	3.3	4.2	1.7	1.9	2.0	0.9	2.0	2.1	1.9
Weight	0.9	4.4	6.8	2.5	2.6	2.4	0.9	1.8	2.0	1.9
Falls in the last year	0.9	1.2	2.2	0.8	1.1	0.7	1.4	0.9	1.1	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.9	-0.5	-0.4	-0.4	-1.7	-0.9	-1.2	-1.1
Forced vital capacity (FVC), Best measure	0.9	3.4	5.8	-1.2	-1.5	-0.9	-2.2	-2.4	-2.3	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.0	-0.8	-0.7	-0.7	-1.4	-1.3	-1.3	-0.5
Knee pain experienced in last month	0.9	1.4	3.1	0.5	0.9	-0.3	-1.8	-1.7	-1.3	-0.9
Miserableness	0.9	1.5	3.3	1.6	1.8	1.6	-0.2	0.9	1.1	0.4
High cholesterol (Self-reported)	0.9	1.6	4.5	1.6	2.1	1.6	-0.7	0.2	0.6	0.6
Depressed Affect (Nagel 2018)	0.8	1.6	3.1	1.4	1.8	1.7	0.1	0.9	1.1	1.1
Schizophrenia vs Biploar Disorder	0.8	1.1	2.6	-1.0	-1.1	-1.6	-0.8	-0.6	-0.5	-1.1
BMI	0.8	4.5	7.9	2.8	2.8	2.5	1.0	1.1	1.8	2.1
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.1	1.8	1.4	1.4	0.3	0.1	-0.1	1.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.1	0.4	0.3	-0.1	-1.4	-1.3	-1.5	-0.9
Pain all over the body in last month	0.8	0.8	2.1	0.3	-0.3	0.3	0.9	1.4	1.4	0.7
Medication: Paracetamol	0.8	1.3	2.9	0.6	0.5	0.6	1.3	1.3	1.3	1.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.3	0.0	0.2	-0.4	-1.5	-1.1	-1.3	-1.2
Number of full brothers	0.8	1.1	1.8	0.7	0.5	0.7	1.4	1.2	1.3	1.2
Number of self-reported non-cancer illnesses	0.8	1.4	3.4	1.6	1.9	1.6	-0.6	0.1	-0.1	0.9
Age started oral contraceptive pill	0.8	1.1	2.3	-1.1	-0.6	-0.7	-1.5	-0.4	-0.8	-1.4
Alzheimer’s Disease (in mother)	0.7	0.9	1.4	-0.9	-0.6	-1.0	-1.1	-0.7	-0.9	-1.2
Ovarian Cancer	0.7	0.9	2.4	-0.3	-0.4	-0.2	-1.6	-0.9	-1.1	-1.4
Fasting Glucose	0.7	0.8	1.7	-1.0	-1.3	-0.8	-0.3	-0.3	-0.8	-1.2
Lupus	0.7	1.1	2.8	1.4	1.7	1.5	-0.3	0.4	-0.1	-0.1
Chronotype (morning person)	0.7	1.6	2.7	1.6	1.2	1.4	1.2	0.8	0.7	1.6
Medication: Co-codamol	0.7	0.8	2.3	0.7	0.8	0.7	0.9	0.6	0.8	1.5
Medication: Simvastatin	0.7	1.0	3.8	1.4	1.9	0.7	-0.6	0.1	0.4	0.4
Hip circumference	0.7	2.9	4.2	1.8	1.8	2.0	0.8	1.7	1.7	1.7
Noisy workplace	0.7	0.9	1.8	1.2	1.2	1.0	0.4	-0.0	0.6	1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	-0.7	-0.9	-0.9	-1.1	-1.0	-1.1	-1.4
Health satisfaction	0.7	1.0	2.0	1.0	1.4	1.2	0.2	0.8	0.9	0.9
Mean time to correctly identify matches	0.7	1.3	2.5	-0.6	-0.4	-1.1	-1.4	-1.6	-1.5	-0.9
Average weekly champagne plus white wine intake	0.7	1.0	4.2	-0.6	-0.9	-0.8	2.0	0.8	0.6	-0.0
Mother’s age at death	0.7	0.8	2.3	-1.4	-1.5	-0.9	-0.0	-0.2	-0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	0.1	0.2	-0.2	-1.5	-0.7	-0.6	-1.7
Schizophrenia (2018)	0.6	1.2	4.0	1.3	2.0	1.5	-0.8	-0.0	0.1	0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.9	-0.1	0.2	-0.7	-1.3	-0.9	-1.0	-1.4
Major Depression (MDD)	0.6	0.7	2.4	0.3	0.6	0.7	-1.6	-0.7	-0.6	-0.8
HbA1C	0.6	0.7	3.2	0.7	0.3	0.4	0.8	0.3	0.5	1.8
Primary Biliary Cirrhosis	0.6	0.9	1.3	0.9	0.6	0.7	1.0	1.1	1.1	1.1
Blood Eosinophil Count	0.6	4.5	8.5	2.9	2.2	2.2	1.2	1.7	1.7	2.6
Cardiovascular Disease	0.6	2.0	4.9	2.1	2.2	1.5	0.1	-0.1	0.5	1.4
Diabetes (father)	0.6	0.7	1.6	0.5	-0.0	-0.0	-1.1	-0.9	-1.1	-1.3
Diabetes (mother)	0.6	0.8	1.4	1.1	0.8	0.7	0.6	1.2	1.1	0.7
Breastfed as a baby	0.6	0.8	2.4	-0.4	-0.5	-0.7	1.6	1.1	1.0	0.1
Pulse wave reflection index	0.6	0.8	1.9	0.8	1.4	0.6	0.3	0.8	1.0	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.3	-0.5	-0.6	-1.1	-0.5	-1.1	-1.0	-0.9
Medication: Aspirin	0.6	0.8	1.8	1.3	1.1	0.5	0.5	0.8	0.9	0.4
Illnesses of father: Heart disease	0.6	0.9	2.7	1.0	0.9	0.6	1.6	0.4	0.4	1.1
Qualifications: nursing, teaching	0.6	1.0	1.4	-1.2	-1.1	-1.0	-1.0	-0.9	-0.9	-0.9
Commuting to job workplace: Walk	0.6	0.6	2.0	-1.0	-1.4	-0.7	-0.1	-0.1	-0.5	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.2	1.1	1.0	1.1	0.3	1.0	0.7	0.7
Back pain experienced in last month	0.6	0.9	2.6	1.1	1.6	1.1	-0.6	0.3	0.7	0.5
Medication: Blood pressure	0.6	1.1	2.3	1.0	1.5	1.2	0.2	0.8	0.9	1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.9	-0.3	0.6	-0.1	-1.7	-1.1	-0.6	-0.5
Illnesses of father: High blood pressure	0.6	0.8	1.7	1.3	1.3	0.5	-0.7	-0.8	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.0	-1.4	-1.7	-1.4	-0.5	-1.0	-1.0	-1.7
Worry (Nagel 2018)	0.5	1.0	1.4	-1.0	-0.9	-1.2	-0.7	-1.0	-1.2	-0.9
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	-0.9	-0.9	-0.8	-0.6	-0.9	-0.8	-0.8
Neuroticism (2016)	0.5	0.8	2.0	1.2	1.1	1.4	-0.2	0.1	0.4	0.6
Systolic Blood Pressure	0.5	2.3	4.4	1.9	2.0	1.0	1.4	0.6	1.0	2.1
Pack years adult smoking proportion	0.5	0.8	1.8	1.3	1.1	1.0	0.2	0.5	0.9	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	1.2	1.1	1.0	-0.4	-0.0	-0.2	0.6
Stomach or abdominal pain in last month	0.5	0.7	2.5	-0.1	-0.3	-0.3	1.3	0.5	0.3	1.6
Had menopause	0.5	0.7	1.8	-0.8	-0.2	-0.5	-1.1	-0.3	-0.7	-1.4
Forced vital capacity (FVC)	0.5	2.0	4.9	-0.5	-1.0	-0.6	-1.3	-2.2	-2.1	-1.1
Worrier / anxious feelings	0.5	0.9	2.1	-1.4	-1.2	-1.4	0.3	-0.4	-0.0	-0.6
Comparative body size at age 10	0.5	1.4	2.9	0.5	0.3	-0.1	-1.5	-1.6	-1.3	-1.7
Wears glasses or contact lenses	0.5	0.6	0.9	-0.8	-0.9	-0.1	-0.9	-1.0	-0.9	0.1
Commuting to job workplace: Public transport	0.5	0.6	1.3	0.0	-0.5	-0.4	-0.9	-1.1	-1.0	-0.9
Medication: Bendroflumethiazide	0.5	0.7	1.8	1.4	1.1	0.7	0.5	0.3	0.4	0.8
Diastolic blood pressure, automated reading	0.5	1.5	4.0	1.9	2.0	1.2	0.3	0.5	0.6	0.7
Pain experienced in last month	0.5	0.8	3.5	-0.2	-0.7	0.1	1.9	0.9	0.8	0.5
Depression (Nagel 2018)	0.4	0.5	1.0	0.9	0.8	0.9	-0.5	-0.2	-0.3	1.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.1	-0.8	-0.6	-1.0	-1.0	-1.4	-0.8	-0.3
Reaction Time	0.4	0.8	2.0	0.6	0.6	-0.1	-1.1	-1.4	-1.3	-0.2
Mean Putamen Volume	0.4	0.5	1.3	-0.5	-0.3	-0.4	-1.1	-0.7	-0.6	-0.9
Number of treatments/medications taken	0.4	0.7	1.8	1.2	1.3	0.8	-0.5	-0.1	-0.2	0.7
Average weekly spirits intake	0.4	0.4	1.4	-0.4	-0.2	-0.1	0.8	1.2	0.9	0.3
Systolic blood pressure, automated reading	0.4	1.0	2.0	1.0	1.4	0.6	0.7	0.8	1.0	1.3
Impedance of leg (right)	0.4	2.1	4.9	0.2	0.0	0.7	2.2	2.2	1.2	1.7
Taking other prescription medications	0.4	0.6	1.8	1.1	1.3	0.8	-0.0	0.5	0.1	0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.0	0.4	0.3	1.0	0.9	0.7	0.9	0.7
Diabetes (self-reported)	0.4	0.7	2.3	1.1	0.7	0.3	0.8	-0.1	0.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	0.1	0.3	0.0	-1.4	-1.1	-0.9	-0.0
Prospective memory result	0.4	0.5	1.0	0.8	0.9	0.6	-1.0	-0.7	-0.3	-0.1
Impedance of arm (left)	0.4	1.8	4.8	-0.0	-0.6	-0.0	2.1	2.2	1.3	1.1
Peak expiratory flow (PEF)	0.4	0.9	2.9	-1.3	-1.7	-0.8	-0.0	-0.4	-0.5	-0.5
Blood clot in the leg (DVT)	0.4	0.5	1.6	-0.1	-0.3	-0.1	1.3	0.8	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	-1.3	-1.2	-0.7	0.6	0.6	0.3	-0.8
Gout (self-reported)	0.4	0.5	1.3	-0.2	-0.1	-0.4	-1.0	-1.1	-1.0	-0.4
Birth weight	0.4	0.9	1.5	-1.2	-1.2	-1.2	-0.5	-0.4	-0.4	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.9	-0.7	-0.6	-1.0	-0.3	-0.5	-0.9
Migraine (self-reported)	0.4	0.4	1.2	0.8	-0.0	-0.1	1.1	0.7	0.4	0.8
Medication: Allopurinol	0.4	0.6	1.4	-0.6	-0.2	-0.4	-1.2	-0.9	-0.9	-0.7
Suffer from ‘nerves’	0.4	0.6	1.4	-0.3	-0.4	-0.4	-1.1	-0.6	-1.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-0.2	-0.3	-0.3	1.0	1.2	0.8	0.2
Mood swings	0.4	0.8	1.9	1.3	1.4	1.0	-0.6	-0.3	-0.4	0.2
Medication: Gliclazide	0.4	0.4	1.1	0.7	0.5	-0.3	1.1	0.4	0.3	0.9
Risk taking	0.4	0.7	1.2	1.1	1.0	0.9	0.5	0.7	0.4	0.8
Ever depressed for a whole week	0.4	0.5	0.9	0.4	0.9	0.9	0.2	0.7	0.8	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.6	-0.4	-0.8	-0.3	0.3	-0.1	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.1	-0.5	-0.5	-0.4	-1.4	-0.7	-0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.0	-0.2	-0.0	1.2	0.8	1.0	0.7
Impedance of whole body	0.4	2.0	5.3	-0.1	-0.5	0.1	2.3	2.2	1.2	1.4
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.9	-1.0	-0.6	0.0	-0.5	-0.9	-0.5
Hypothyroidism (self reported)	0.3	0.7	2.2	0.8	0.3	0.5	1.1	0.5	0.3	1.5
Lung FEV1/FVC ratio	0.3	1.7	2.5	-1.3	-1.6	-1.1	-1.2	-1.5	-1.4	-0.9
Sensitivity / hurt feelings	0.3	0.5	1.0	0.9	0.7	0.4	1.0	0.5	0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.8	0.3	0.4	0.6	1.4	0.9	0.6	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	0.9	0.8	0.1	0.6	0.2	0.3	0.6
Number of incorrect matches in round	0.3	0.5	1.2	0.1	0.8	0.0	-1.1	-0.8	-0.9	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.2	-0.7	-0.7	-1.1	-0.6	-0.3	-0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	0.2	0.1	0.4	1.3	1.0	0.8	1.2
Mouth/teeth dental problems	0.3	0.5	1.1	-1.0	-1.1	-1.0	-0.1	0.3	0.5	-0.3
Heart attack	0.3	0.4	1.7	-0.4	-0.5	-0.3	-1.3	-0.4	-0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.9	1.0	0.5	0.9	-0.1	0.2	-0.1	0.6
Medication: Ramipril	0.3	0.4	1.3	-0.4	-0.7	-0.2	-0.6	-1.1	-0.6	0.0
Impedance of arm (right)	0.3	1.4	4.2	-0.2	-0.8	-0.1	1.8	2.1	1.1	0.7
Alcohol intake versus 10 years previously	0.3	0.5	2.3	0.2	0.4	0.6	-1.5	-0.6	-0.4	-0.4
Happiness	0.3	0.4	0.6	-0.7	-0.6	-0.5	-0.8	-0.6	-0.5	-0.6
Asthma	0.3	0.5	1.4	0.2	0.4	0.5	-1.1	-0.3	-1.2	-0.7
Medication: Cholesterol lowering	0.3	0.4	1.3	0.9	1.2	0.4	-0.5	-0.3	-0.1	0.4
Tense / ‘highly strung’	0.3	0.5	0.9	-0.3	0.1	-0.9	-0.4	-0.8	-0.9	-0.9
Worry too long after embarrassment	0.3	0.4	1.2	-0.5	-0.5	-0.4	-0.8	-0.3	-0.6	-1.1
Medication: Blood pressure	0.3	0.5	1.1	1.0	0.7	0.3	-0.6	-0.9	-0.8	0.7
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.7	-0.7	-0.3	-0.8	-0.7	-0.6	0.2
Comparative height size at age 10	0.3	1.8	3.1	-0.6	-0.2	-0.8	-1.7	-1.7	-1.7	-1.8
Overall health rating	0.3	0.6	1.4	0.9	1.2	0.9	-0.6	0.4	0.2	0.7
Long-standing illness, disability or infirmity	0.3	0.5	0.7	0.8	0.8	0.6	-0.7	-0.6	-0.7	0.5
Diabetes diagnosed by doctor	0.3	0.6	2.0	1.0	0.7	0.3	0.7	-0.0	-0.1	1.4
Asthma (self-reported)	0.3	0.5	1.4	0.4	0.5	0.7	-1.0	-0.3	-1.2	-0.6
Guilty feelings	0.3	0.5	0.9	0.8	0.7	1.0	0.3	0.3	0.7	0.9
Myopia	0.3	0.5	1.8	-0.2	-0.1	-0.3	-1.3	-0.5	-0.8	-0.7
Pack years of smoking	0.3	0.5	1.0	1.0	0.9	0.6	-0.1	0.4	0.8	0.7
Crohns Disease (2017)	0.2	0.5	1.3	-0.5	-0.5	-0.4	0.8	0.3	0.7	1.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	0.8	0.5	1.0	-0.5	0.8	-0.0	-0.7
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	-0.8	-0.8	0.0	-0.4	0.0	0.1
Schizophrenia (2014)	0.2	0.4	1.2	0.1	0.7	0.1	-1.1	-0.5	-0.5	-0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.0	0.5	0.5	0.6	0.7	1.4	1.1	1.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.4	0.6	0.5	-0.2	0.4	0.6	0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	1.0	0.5	0.7	-1.0	-0.4	-0.9	-0.2
Sitting height	0.2	1.5	3.7	-1.2	-1.9	-1.1	-0.4	-0.9	-1.5	-1.2
Impedance of leg (left)	0.2	1.2	3.0	-0.1	-0.3	0.3	1.7	1.7	0.9	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	1.1	1.0	0.3	-0.0	0.0	0.3	0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.5	-0.2	-0.3	0.6	0.3	0.3	0.6
Had other major operations	0.2	0.3	1.3	-0.7	-1.1	-0.3	0.0	0.1	-0.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.0	0.8	0.5	-0.4	0.3	0.4	0.3
Fluid intelligence score	0.2	0.4	0.9	-0.9	-0.8	-0.7	-0.1	0.0	-0.3	-0.9
Illnesses of siblings	0.2	0.3	1.0	0.7	0.6	1.0	0.2	0.2	-0.2	0.3
Trunk fat-free mass	0.2	0.9	1.4	1.0	1.1	1.0	-1.2	-1.0	-0.7	-0.3
Number of live births	0.2	0.3	0.6	-0.7	-0.4	-0.5	-0.8	-0.3	-0.2	-0.6
Pulse rate	0.2	0.3	0.7	0.2	-0.7	0.0	0.0	-0.8	-0.8	-0.2
Trunk predicted mass	0.2	0.9	1.3	1.1	1.1	1.1	-1.1	-0.9	-0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.2	0.0	0.3	0.6	1.0	0.9	0.7
Birth weight of first child	0.2	0.4	0.9	-0.9	-0.9	-0.8	-0.3	-0.3	0.1	-0.3
Glaucoma (self-reported)	0.2	0.2	0.5	-0.4	-0.2	-0.2	-0.7	-0.7	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	0.9	0.3	0.7	0.8	0.1	0.1	1.1
Arm fat-free mass (right)	0.2	0.8	1.7	1.1	1.3	1.2	-0.8	-0.6	-0.2	0.1
Number of children fathered	0.2	0.2	0.7	-0.6	-0.6	-0.9	0.1	0.2	0.3	-0.3
Heart disease (mother)	0.2	0.2	0.4	-0.3	-0.6	-0.3	0.3	0.6	0.6	-0.2
Arm predicted mass (right)	0.2	0.8	1.4	0.9	1.1	1.1	-1.2	-0.9	-0.5	-0.2
Leg pain on walking	0.2	0.3	0.7	0.9	0.7	0.7	0.2	-0.3	0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.7	-0.8	-0.2	0.2	0.2	0.1	0.2
Illnesses of siblings: Diabetes	0.2	0.3	1.1	0.2	-0.2	-0.2	0.7	0.3	0.6	1.1
Ever had bowel cancer screening	0.2	0.2	0.3	0.0	-0.1	-0.3	-0.5	-0.5	-0.6	-0.6
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	-0.5	-0.6	0.3	-0.1	-0.2	-0.1
Medication for cholesterol	0.2	0.2	0.7	-0.5	-0.8	-0.3	0.3	0.2	-0.2	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.9	0.1	1.0	0.2	-0.5	0.2	0.4	-0.4
Whole body water mass	0.2	0.9	1.4	1.0	1.1	1.0	-1.2	-0.8	-0.6	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.7	-0.5	-0.2	-0.7	-0.4	-0.4	-0.4
Basal metabolic rate	0.2	1.0	2.5	1.5	1.6	1.4	-0.7	-0.2	0.1	0.2
Arm fat-free mass (left)	0.2	0.8	1.6	1.0	1.2	1.1	-1.2	-0.7	-0.4	-0.2
Irritability	0.2	0.3	0.9	0.0	-0.2	-0.0	1.0	0.5	0.5	0.6
Unable to work because of sickness or disability	0.2	0.2	0.7	0.5	0.2	0.6	0.2	0.0	0.2	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.4	0.5	0.8	0.4	0.0	0.2	0.6
Supplements: Calcium	0.2	0.2	0.5	-0.4	-0.3	-0.2	-0.6	0.4	0.5	-0.7
Arm predicted mass (left)	0.2	0.9	1.7	0.9	1.2	1.0	-1.3	-0.8	-0.5	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.5	0.9	0.7	-0.6	-0.4	-0.5	0.0
Breast Cancer	0.1	0.2	0.8	0.1	-0.3	-0.1	-0.3	-0.2	-0.7	-0.9
Prostate Cancer	0.1	0.1	0.4	0.3	0.3	0.3	-0.6	-0.3	-0.2	-0.1
Age at First Birth	0.1	0.2	0.6	0.4	0.5	0.8	0.3	0.4	0.3	0.2
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.2	-0.1	0.5	0.4	0.5	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.0	0.1	0.2	0.2
Allergy or Eczema	0.1	0.2	0.4	0.7	0.2	0.6	-0.5	0.0	-0.4	0.1
Respiratory disease	0.1	0.2	0.5	0.4	0.7	0.7	-0.5	0.1	-0.5	-0.2
Relative age of first facial hair	0.1	0.2	0.5	-0.7	-0.6	-0.5	-0.1	0.3	0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.3	0.3	0.1	-0.5	0.4	0.4	-0.6
Severe depression (siblings)	0.1	0.1	0.5	0.0	0.2	0.7	0.1	0.5	0.3	-0.0
Leg fat-free mass (left)	0.1	0.7	1.7	1.2	1.3	1.1	-0.9	-0.4	-0.2	-0.2
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.2	0.1	-0.4	-0.4
Relative age voice broke	0.1	0.1	0.4	-0.6	-0.6	-0.5	-0.2	-0.0	-0.2	0.1
Age when periods started (menarche)	0.1	0.1	0.5	0.3	0.0	0.4	-0.7	-0.1	-0.4	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.6	0.2	0.4	0.4	0.1	0.0	0.7
Leg predicted mass (left)	0.1	0.7	1.5	1.1	1.2	1.0	-0.8	-0.4	-0.2	-0.2
Allergy	0.1	0.2	0.6	-0.8	-0.3	-0.7	0.3	-0.2	0.4	-0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	0.3	0.0	-0.0	0.6	0.1	-0.0	0.7
Depression (self-reported)	0.1	0.2	0.4	0.7	0.6	0.5	-0.4	-0.0	0.1	0.2
Length of working week for main job	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.4	0.4	0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.2	0.4	-0.3	-0.4	0.2	-0.1	-0.2
Emphysema/chronic bronchitis	0.1	0.2	0.5	-0.5	-0.7	-0.3	0.4	0.2	0.1	0.2
Medication: Omeprazole	0.1	0.2	0.5	-0.1	0.2	-0.3	0.2	0.7	0.3	-0.6
Family relationship satisfaction	0.1	0.1	0.1	0.3	0.3	0.2	0.3	0.3	0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.2	-0.9	-0.0	0.2	-0.4	-0.7	-0.2
Whole body fat-free mass	0.1	0.8	1.3	1.1	1.1	1.0	-1.1	-0.8	-0.6	-0.3
Leg fat-free mass (right)	0.1	0.6	1.3	0.9	0.9	0.8	-1.2	-0.7	-0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.1	-0.2	0.1	0.2	-0.7	-0.7	-0.2
Leg predicted mass (right)	0.1	0.6	1.1	0.9	0.9	0.8	-1.0	-0.6	-0.4	-0.5
Hearing aid user	0.1	0.1	0.3	-0.6	-0.3	-0.4	-0.1	-0.2	-0.1	-0.0
Number of operations (self-reported)	0.1	0.2	0.3	-0.5	-0.5	0.0	0.6	0.4	0.3	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.1	-0.1	0.1	0.3	-0.0	0.4	0.4
Cholesterol lowering medication	0.1	0.2	0.7	-0.0	0.4	-0.1	-0.9	0.1	0.3	-0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.6	0.0	-0.0	-0.8	0.3	0.2	-0.3	-0.3
Heart disease (siblings)	0.1	0.1	0.2	0.0	0.3	0.2	-0.4	0.2	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	-0.0	0.0	0.2	-0.1	0.5	-0.0	-0.6
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.2	0.4	0.3	-0.3	-0.0	0.1	0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	0.2	0.1	-0.3
LDL Cholesterol	0.0	0.0	0.2	0.0	0.3	0.4	-0.2	-0.1	-0.1	0.1
Heel T-Score	0.0	0.1	0.2	-0.0	-0.1	-0.2	0.3	0.2	0.1	-0.5
Height	0.0	0.3	0.9	0.7	0.3	1.0	-0.2	0.5	-0.4	-0.3
Neuroticism	0.0	0.0	0.0	0.0	0.2	0.2	-0.2	0.0	0.1	-0.2
Hair Pigment	0.0	1.3	2.3	1.4	1.1	1.5	1.1	0.9	0.8	1.2
Tanning	0.0	0.3	0.6	0.3	0.6	0.8	0.4	0.6	0.4	0.8
Nervous feelings	0.0	0.1	0.2	-0.2	-0.3	0.1	-0.3	0.1	-0.3	-0.5
Neuroticism score	0.0	0.1	0.3	0.1	0.1	0.0	-0.5	-0.3	-0.3	-0.5
Standing height	0.0	0.2	0.7	0.1	-0.2	0.3	-0.3	-0.1	-0.8	-0.5
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.2	-0.1	0.1	-0.5	-0.2	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.4	0.1	0.0	0.3	-0.0	-0.3	-0.0
Shortness of breath walking on level ground	0.0	0.1	0.2	-0.4	-0.4	0.0	0.1	0.1	0.2	-0.0
Pulse rate, automated reading	0.0	0.2	0.4	0.7	-0.0	0.4	0.6	0.2	-0.1	-0.2
Friendships satisfaction	0.0	0.0	0.1	0.4	0.2	0.1	0.1	-0.0	0.1	0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.1	-0.2	0.0	0.2	-0.0	-0.3	-0.0

Hub : Genes

SCN11A

Models

Trait associations