Hub : Genes

ITGA9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1590	0.0400	5.2e-09	0.097	0.080	0.101	0.089	0.103	7.4e-12	5.7e-10	2.5e-12	5.6e-11	1.7e-12
2	GTEx	Brain Cerebellum	0.3880	0.1070	1.6e-03	0.176	NA	0.191	NA	0.208	6.7e-06	NA	2.6e-06	NA	8.8e-07
3	METSIM	Adipose	0.0814	0.0268	1.8e-07	0.054	0.062	0.063	0.063	0.062	1.5e-08	1.1e-09	9.4e-10	9.2e-10	1.2e-09
4	ROSMAP	Brain Pre-frontal Cortex	0.0978	0.0357	2.6e-04	0.003	0.011	0.008	0.016	0.007	1.3e-01	1.3e-02	2.7e-02	3.4e-03	4.1e-02
5	TCGA	Brain Lower Grade Glioma	0.0507	0.0242	4.3e-03	0.014	0.020	0.011	NA	0.019	8.8e-03	2.2e-03	1.8e-02	NA	3.0e-03
6	TCGA	Thyroid Carcinoma	0.0450	0.0210	2.3e-03	0.047	0.019	0.049	NA	0.060	2.3e-05	5.5e-03	1.4e-05	NA	1.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	4.0	0.9	0.5	-2.0	1.2	-1.8	1.8
Bipolar Disorder or Schizophrenia	4.3	10.5	17.5	2.6	2.2	-3.8	3.7	-4.2	2.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	0.7	-0.2	-0.3	0.5	0.1	0.8
Depression (Nagel 2018)	1.2	1.9	4.3	0.4	1.7	-1.4	1.1	-0.7	2.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.8	-0.8	0.1	-0.6	0.3	-0.2
Neuroticism (Nagel 2018)	0.4	1.0	2.8	0.4	0.1	-1.0	1.4	-0.2	1.7
Schizophrenia (2018)	4.5	9.3	15.5	2.6	2.5	-3.2	3.7	-3.9	1.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	-0.1	-0.5	0.4	0.8	-0.2	0.3
Worry (Nagel 2018)	1.1	2.4	5.5	0.8	1.4	-1.4	2.3	-0.9	1.8
Alzheimer’s Disease (in mother)	4.1	4.8	9.1	1.7	2.2	-2.6	1.8	-3.0	1.4
Alzheimer’s Disease (in father)	0.7	0.8	1.8	0.7	-1.2	-0.7	-0.4	-0.7	1.4
Alzheimer’s Disease (including proxy)	4.0	5.8	14.1	1.5	2.0	-3.0	1.0	-3.8	2.0
Crohns Disease (2017)	0.4	0.9	1.8	-1.0	0.9	-0.8	-1.0	-1.3	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	0.9	-0.3	-1.0	0.1	-0.4	-0.1
Ulcerative Colitis (UC)	1.0	1.9	6.1	2.5	-1.0	-1.5	1.3	0.5	-0.0
Major Depression (MDD)	1.7	2.0	5.9	-0.5	1.3	-1.5	0.6	-1.3	2.4
Reaction Time	0.8	1.6	4.6	1.1	0.7	-2.2	0.4	-1.6	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-0.9	-0.7	0.4	0.2	1.3	-1.5
Breast Cancer	1.8	4.2	7.8	1.6	2.7	-2.6	1.0	-2.8	0.0
Ovarian Cancer	0.8	1.0	1.8	1.1	0.1	-1.3	-0.9	0.5	-1.3
Prostate Cancer	1.7	2.4	4.5	0.4	1.8	-1.8	0.3	-1.8	2.1
Age at First Birth	0.8	1.2	3.5	1.9	0.6	-0.6	-0.1	-1.0	-1.4
Bipolar Disorder (2011)	4.1	3.9	6.8	0.6	1.9	-2.6	1.3	-2.3	2.4
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-0.5	-0.6	1.1	-0.8	-0.5	-0.4
Coronary Artery Disease (CAD)	2.5	3.0	8.0	-0.8	-1.4	2.3	-1.3	2.8	-0.6
Crohns Disease (2012)	1.0	1.6	5.3	-2.3	0.7	0.3	-1.5	-0.9	-0.6
Mean Putamen Volume	1.1	1.2	5.2	-2.3	0.3	0.9	0.7	0.4	0.9
Fasting Glucose	0.8	1.0	2.0	-0.1	-1.2	1.1	0.7	1.4	-0.9
HbA1C	0.9	1.0	2.1	-1.1	1.5	-0.2	-0.8	-1.4	0.3
HDL Cholesterol	0.6	1.0	2.2	1.5	-0.1	0.0	0.5	1.5	-1.2
LDL Cholesterol	0.3	0.5	1.2	-1.1	-0.3	0.1	-0.7	1.0	-0.6
Lupus	0.6	1.0	3.3	-0.4	1.8	-0.3	0.9	-1.1	0.5
Neuroticism (2016)	2.1	3.0	10.0	0.0	0.2	-3.2	-0.3	-2.2	1.8
Primary Biliary Cirrhosis	2.9	4.1	11.4	-0.8	2.3	-1.4	0.8	-2.1	3.4
Rheumatoid Arthritis	1.1	1.4	4.7	-1.1	-2.2	1.5	0.0	0.7	0.1
Schizophrenia (2014)	2.9	6.4	10.3	1.9	2.0	-2.6	3.2	-3.0	2.2
Triglycerides	0.7	1.1	4.0	-1.3	-0.4	-0.1	-2.0	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	-0.4	0.4	1.2	-0.0	0.8	-0.2
Ulcerative Colitis	0.3	0.5	1.4	1.1	-0.1	-1.2	0.4	-0.3	0.1
Blood Eosinophil Count	0.3	2.2	5.1	2.3	0.5	-2.0	-0.6	-1.8	0.1
Blood Platelet Count	0.9	10.9	34.9	1.3	5.9	-3.9	0.7	-3.1	1.8
Blood Red Count	0.4	3.8	7.5	0.1	-2.6	0.5	-2.6	2.7	-1.2
Blood White Count	0.3	2.0	4.2	1.6	2.0	-0.5	2.0	-0.8	-0.4
Heel T-Score	0.5	3.8	6.2	2.1	1.1	-2.5	1.5	-2.5	1.6
BMI	0.4	2.4	6.2	-2.5	1.3	-1.2	-2.1	-0.3	0.7
Height	0.7	12.6	35.4	-3.0	-1.9	6.0	3.0	4.3	-0.2
Waist Hip Ratio (WHR)	4.8	21.8	35.0	0.2	5.9	-5.3	2.0	-5.4	5.8
Systolic Blood Pressure	3.1	15.5	27.5	-2.7	-5.2	4.6	-2.4	4.0	-3.9
Smoking Status	0.3	0.8	3.7	-0.7	0.5	-0.1	0.8	0.0	1.9
Allergy or Eczema	0.6	1.6	3.3	1.1	0.2	1.8	0.8	1.5	-1.5
Cardiovascular Disease	0.2	0.8	1.5	0.1	-0.8	1.0	-0.9	1.2	-1.1
Hypothyroidism (self reported)	1.4	3.1	7.2	-2.7	0.2	2.0	0.5	2.2	1.6
Respiratory disease	0.4	0.9	2.4	1.0	0.1	-1.2	0.4	-1.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.0	3.1	-0.5	0.5	1.2	-1.8	1.1	-0.2
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.8	-0.1	0.0	-0.8	-0.6	-0.0
Lung FVC	1.5	7.7	13.1	2.6	3.3	-3.2	0.7	-3.6	2.2
Neuroticism	0.6	1.4	2.7	0.5	0.6	-1.7	1.3	-0.8	1.5
Chronotype (morning person)	1.5	3.5	6.8	-1.2	-1.3	1.4	-1.8	2.4	-2.6
Hair Pigment	0.1	1.6	4.2	0.1	0.9	-1.4	0.1	-1.6	2.0
Tanning	0.1	1.2	2.2	1.5	0.9	-1.4	1.0	-1.2	0.1
Hand grip strength (left)	0.6	1.7	3.8	-1.1	-1.0	1.6	-1.9	0.8	1.1
Number of treatments/medications taken	0.7	1.3	2.9	-1.1	1.0	-1.2	-1.1	-1.7	0.0
Average weekly spirits intake	3.9	4.9	11.2	1.5	2.0	-2.9	0.9	-3.4	1.5
Sensitivity / hurt feelings	0.2	0.4	1.3	-0.8	-0.1	-0.3	1.1	0.6	0.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.4	1.6	0.7	-0.8	1.8	-0.4	1.6
Hearing difficulty/problems: Yes	1.0	1.5	6.0	-0.0	-2.5	1.1	0.7	0.3	-1.2
Relative age of first facial hair	0.2	0.3	1.1	-1.1	0.3	0.8	-0.2	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	9.8	-3.1	0.5	0.0	-0.4	-0.4	-1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.9	0.1	0.1	0.4	-0.8	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	0.4	-0.1	-0.5	0.2	0.6
Systolic blood pressure, automated reading	3.9	11.3	24.3	-2.8	-4.9	3.8	-2.2	2.8	-2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.2	-0.5	-0.7	1.8	0.2	0.8	-0.8
Angina	0.6	0.8	1.5	1.2	0.6	-0.8	1.1	0.3	-1.0
Medication for hormone replacement therapy	0.9	1.1	3.8	-0.6	0.2	-0.6	0.6	-1.9	1.2
Vitamin and mineral supplements	0.4	0.6	1.7	1.3	-0.8	-0.5	0.2	1.0	0.1
Supplements: Zinc	0.7	0.8	1.5	0.8	0.4	-0.4	-1.2	-1.2	-1.0
Medication: Co-codamol	0.8	1.0	4.0	-0.7	-2.0	0.2	1.0	-0.5	-0.2
Medication: Metformin	0.3	0.4	1.5	0.1	1.2	-0.3	-0.0	-0.6	0.8
Diabetes (father)	0.2	0.3	1.4	0.6	1.2	-0.0	-0.1	0.3	0.2
Diabetes (mother)	0.6	0.8	1.5	-1.2	-0.2	1.2	0.7	0.8	0.8
Severe depression (siblings)	0.9	1.0	3.4	-0.1	1.8	-0.8	-0.8	-0.8	0.6
Pack years adult smoking proportion	0.5	0.8	1.5	1.2	0.9	-1.2	0.7	-0.6	0.6
Impedance of leg (right)	0.2	0.9	3.5	1.9	0.5	0.6	0.2	1.2	0.2
Leg fat-free mass (left)	0.3	1.6	7.4	-2.7	0.1	1.0	-0.9	0.2	0.4
Trunk fat percentage	0.6	2.5	11.4	-3.4	0.6	0.2	-1.7	0.2	0.3
Hand grip strength (right)	0.4	1.1	4.2	0.5	0.3	0.7	-1.3	0.1	2.0
Townsend deprivation index at recruitment	0.3	0.5	0.9	-1.0	-0.0	-0.3	0.8	-1.0	0.5
Current tobacco smoking	1.1	1.8	6.2	-1.4	-0.5	1.5	-0.4	0.3	2.5
Average weekly fortified wine intake	0.2	0.2	1.0	0.3	-1.0	0.1	-0.4	-0.0	-0.2
Maternal smoking around birth	0.2	0.3	1.1	-0.6	-0.3	1.0	0.0	-0.1	-0.3
Fed-up feelings	0.4	0.8	2.3	1.5	-0.7	-0.2	0.8	-0.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.6	0.3	1.6	0.0	0.2	-0.0	1.5
Relative age voice broke	0.5	0.8	1.4	-0.3	-0.9	0.8	-1.2	0.9	-1.0
Taking other prescription medications	0.1	0.2	0.4	-0.5	0.3	-0.7	-0.4	0.5	0.3
Age when periods started (menarche)	0.5	1.2	2.0	-1.4	0.0	1.2	-1.2	1.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.4	0.5	-0.4	-0.2	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.4	0.7	0.2	-1.6	0.3	-1.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.4	-0.4	-0.6	0.4	-1.8	-0.4	-1.3
Qualifications: CSEs or equivalent	0.4	0.5	2.1	1.5	-0.2	-0.4	0.8	-0.0	-0.2
Serious illness, injury or assault to yourself	0.4	0.4	0.9	-0.6	0.9	-0.7	-0.3	-0.8	0.5
High blood pressure	0.8	2.4	3.9	-0.2	-2.0	1.3	-1.9	1.5	-1.6
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.3	-0.3	-1.0	1.7	-0.3	1.8	-1.2
Multivitamins +/- minerals	0.5	0.6	2.8	-0.2	0.6	-0.4	-0.2	-1.7	0.2
Stomach or abdominal pain in last month	2.3	2.9	6.1	1.9	2.5	-1.2	2.0	-1.3	-0.5
Supplements: Glucosamine	0.8	1.1	2.8	-1.1	-0.4	0.8	-1.7	-0.9	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.8	2.0	0.3	0.6	0.7	1.7	-0.6
Medication: Atenolol	1.0	1.2	3.2	1.4	1.1	-1.0	-1.8	-0.5	-0.2
Medication: Levothyroxine sodium	1.4	2.4	5.7	-1.5	-0.3	2.0	1.4	2.4	-0.4
Sitting height	0.6	4.5	20.2	-1.6	-0.7	4.5	0.1	1.9	-0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	0.4	-0.6	0.6	-0.8	1.5	1.0
High blood pressure (mother)	1.3	1.8	5.7	0.4	-0.7	1.9	-0.1	2.4	-0.9
Body mass index (BMI)	0.5	2.1	6.2	-2.4	0.3	-0.8	-2.5	-0.1	0.2
Impedance of leg (left)	0.2	0.8	2.0	1.4	1.2	0.2	0.4	0.6	0.7
Leg predicted mass (left)	0.3	1.6	7.6	-2.8	0.1	0.9	-1.0	0.3	0.4
Trunk fat mass	0.7	3.1	13.2	-3.6	0.8	0.5	-2.0	0.4	0.5
Waist circumference	1.0	3.8	8.9	-3.0	1.7	-1.1	-2.0	-1.0	2.2
Number of incorrect matches in round	0.7	1.2	3.3	-0.7	-1.8	1.2	-0.7	0.9	0.8
Past tobacco smoking	0.5	0.9	2.5	0.0	-0.5	1.6	-1.4	0.6	-0.2
Alcohol usually taken with meals	1.1	1.8	6.2	-0.3	2.5	-0.4	-0.5	-1.5	1.3
Nervous feelings	0.8	1.6	3.1	0.1	0.8	-1.6	1.7	-1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.3	1.1	-0.0	-0.1	0.3	0.6	2.1
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.3	-0.2	0.1	-1.1	-0.7	-1.3
Hair/balding pattern: Pattern 2	3.6	4.6	10.2	2.1	1.8	-3.2	0.9	-2.9	-0.2
Had menopause	0.1	0.1	0.2	-0.4	0.3	-0.0	0.4	-0.4	0.1
Had other major operations	1.9	2.3	8.6	-2.9	0.3	0.5	-1.5	0.7	1.4
Forced vital capacity (FVC)	0.9	3.5	6.1	1.9	2.1	-1.3	1.2	-2.0	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.1	-0.3	-0.9	-0.2	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.6	0.9	-0.6	0.1	-0.4	-0.2
Qualifications: None of the above	0.9	2.0	7.0	-1.0	-1.0	-1.0	0.9	-0.9	2.6
Financial difficulties in last 2 years	0.9	1.2	3.1	-0.1	-1.6	1.7	0.3	1.2	-0.4
Mouth/teeth dental problems	0.8	1.2	4.2	-0.2	0.5	-0.2	-1.5	0.6	-2.0
Heart attack	0.7	0.9	1.5	-0.7	1.0	0.6	-0.9	1.1	-1.2
Allergy	0.1	0.2	0.6	0.5	0.6	-0.3	0.2	-0.2	0.8
Pain all over the body in last month	0.4	0.4	1.4	-0.5	0.0	-0.7	-0.3	-1.2	0.3
Diabetes (self-reported)	0.1	0.1	0.4	-0.1	0.6	0.0	-0.0	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	1.1	-0.1	-0.1	0.5	0.3	0.8
Medication: Ramipril	0.9	1.2	2.7	-0.5	-0.7	1.6	-0.5	0.9	-1.6
Medication: Simvastatin	0.7	1.0	5.0	0.2	0.9	-0.1	-2.2	0.7	0.0
Fluid intelligence score	0.3	0.6	2.1	-0.6	-0.6	0.0	-0.4	0.7	-1.4
Illnesses of siblings	3.6	5.1	8.6	2.7	1.6	-2.9	2.2	-2.5	0.9
Neuroticism score	0.5	1.0	2.1	0.3	-0.2	-1.2	1.4	-0.6	1.5
Weight	0.5	2.7	11.5	-3.4	0.7	0.6	-1.8	0.3	0.7
Impedance of arm (right)	0.3	1.6	7.1	0.1	1.0	-0.8	2.7	-0.9	0.4
Arm fat percentage (right)	0.5	2.1	8.1	-2.9	0.5	-1.1	-1.6	-0.7	0.3
Trunk fat-free mass	0.4	2.2	4.9	-2.2	0.1	2.0	-1.5	1.1	0.7
Hip circumference	0.9	3.8	7.6	-2.8	-1.7	1.6	-2.6	1.6	-0.2
Time employed in main current job	2.0	2.3	5.2	1.5	-2.3	-0.2	1.9	0.2	1.5
Alcohol intake versus 10 years previously	0.7	1.1	4.8	0.2	-2.2	-0.0	0.2	-0.1	-1.2
Father’s age at death	0.4	0.5	1.1	-0.0	1.1	0.2	-0.3	-1.0	0.9
Worrier / anxious feelings	0.5	1.0	1.4	-0.3	1.0	-1.1	1.1	-1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.8	-0.1	-0.1	0.0	-0.5	-0.0	1.9
Falls in the last year	2.3	3.1	12.0	-2.2	0.3	-0.5	-3.5	-1.0	0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	-0.0	-0.7	-0.0	-0.3	0.2	-1.3
Number of live births	0.6	0.8	2.2	-0.5	1.0	-0.3	-0.6	-1.0	1.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.6	1.5	1.9	-1.2	0.2	-2.1	1.5
Pulse rate	1.2	2.0	4.6	0.7	1.8	-2.1	1.8	-0.2	0.5
Happiness	0.3	0.3	1.3	1.1	0.1	-0.3	0.0	0.4	0.6
Noisy workplace	1.1	1.4	2.3	0.8	0.5	-1.5	1.1	-1.4	1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.8	1.7	1.3	-0.8	0.6	-0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	5.9	-0.7	2.4	-1.1	0.7	-1.2	2.1
Mouth/teeth dental problems: Dentures	0.9	1.6	4.3	-0.1	-1.8	1.0	-0.1	2.1	1.0
Asthma	0.2	0.4	1.9	-0.1	0.1	-1.4	-0.4	-0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.5	-0.6	1.1	-0.4	1.1	-2.1	0.8
Medication: Cholesterol lowering	0.6	1.0	2.2	-0.3	0.4	0.5	-1.4	1.5	-1.1
Depression (self-reported)	2.8	3.4	10.3	0.4	3.2	-1.6	-1.2	-1.4	1.9
Medication: Lansoprazole	0.8	0.9	2.1	1.5	1.4	-0.8	-0.2	-0.6	-0.3
Prospective memory result	1.5	1.8	3.5	-1.9	-1.2	1.3	-1.3	1.4	0.5
Lung cancer (father)	0.4	0.4	1.0	-0.3	-0.8	-0.7	-1.0	-0.2	-0.4
Illnesses of mother	1.1	1.4	3.3	0.0	0.6	-1.8	1.0	-1.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	7.6	2.8	2.6	-2.4	1.5	-2.6	1.5
Pulse wave Arterial Stiffness index	1.5	1.7	5.4	-0.7	-1.6	1.1	-0.8	2.3	-0.5
Impedance of arm (left)	0.4	1.9	7.9	0.6	1.1	-0.8	2.8	-1.1	0.3
Arm fat mass (right)	0.6	2.3	10.2	-3.2	0.5	0.1	-1.8	0.2	0.5
Trunk predicted mass	0.4	2.1	4.8	-2.2	0.2	2.0	-1.4	1.2	0.6
Standing height	0.4	3.6	10.6	-2.6	0.7	3.2	1.0	1.2	1.1
Length of working week for main job	0.1	0.2	0.4	-0.2	0.6	0.6	-0.1	0.3	0.1
Exposure to tobacco smoke at home	0.9	1.0	2.0	-0.6	-0.9	0.9	-1.1	0.9	-1.4
Breastfed as a baby	0.2	0.3	1.0	-0.3	-0.3	0.2	-0.6	1.0	-0.4
Tense / ‘highly strung’	0.7	1.1	4.2	0.3	0.6	-0.5	0.8	-1.0	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	9.7	-0.5	3.1	-2.0	-0.3	-2.1	2.0
Hair/balding pattern: Pattern 4	1.0	2.3	5.6	-1.6	-2.4	1.3	-0.9	1.0	-1.5
Birth weight of first child	0.3	0.6	1.5	-0.7	-0.8	1.2	-0.8	-0.1	-0.6
Peak expiratory flow (PEF)	0.4	0.8	1.4	0.6	1.2	-1.2	-0.7	-1.0	0.4
Pulse wave reflection index	2.4	3.0	5.9	-1.3	-1.9	2.4	-0.4	2.4	-0.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.3	-0.8	0.0	1.5	0.7	1.4	-0.2
Loud music exposure frequency	1.5	1.7	2.6	-1.3	-1.0	1.6	-0.1	1.6	-1.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.1	2.0	-0.1	0.1	0.5	0.7	-1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.7	0.6	0.8	-0.3	2.4	-1.9	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.9	-0.2	-0.2	-0.3	-1.0	0.2	0.5
Medication: Paracetamol	0.7	1.2	2.6	-0.7	1.2	-1.2	-0.6	-1.6	1.1
Headache pain in last month	1.1	2.0	5.8	-0.5	2.1	-0.9	0.2	-0.6	2.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.2	0.5	1.1	-1.0	1.5	-1.8	2.3
Glaucoma (self-reported)	2.6	3.1	5.7	-2.3	-1.3	1.3	-2.4	1.0	-1.9
Gout (self-reported)	0.2	0.3	0.6	-0.4	-0.8	0.2	-0.2	0.5	-0.7
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	8.4	-2.9	0.2	2.3	0.1	2.4	0.2
Medication: Amlodipine	0.3	0.4	1.1	-0.0	0.0	-0.4	-1.1	-0.1	-1.1
Medication: Ventolin 100micrograms inhaler	1.6	2.0	3.8	0.5	1.6	-1.9	0.8	-1.6	1.6
Birth weight	0.1	0.3	0.7	0.8	-0.8	0.1	0.0	-0.3	0.4
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.1	0.3	0.1	-0.3	-0.0	0.2
High blood pressure (siblings)	6.3	9.1	14.2	-3.4	-2.4	3.8	-3.5	3.2	-1.1
Forced vital capacity (FVC), Best measure	1.6	5.8	7.5	2.4	2.7	-2.3	2.1	-2.5	2.3
Body fat percentage	0.7	2.7	10.6	-3.3	0.9	-0.4	-2.2	0.1	0.3
Leg fat percentage (right)	0.7	2.5	7.5	-2.0	1.4	-1.1	-2.7	0.3	0.4
Arm fat-free mass (right)	0.5	2.4	5.1	-2.2	-0.0	2.2	-1.7	1.2	0.6
Exposure to tobacco smoke outside home	0.5	0.6	1.4	-1.2	-0.6	1.0	0.3	0.5	-0.8
Comparative body size at age 10	0.5	1.3	3.2	1.8	-0.7	-1.6	0.8	-0.8	-0.4
Number of full brothers	0.2	0.3	1.0	-0.1	-0.4	0.7	-1.0	0.0	0.3
Worry too long after embarrassment	0.4	0.7	2.4	-1.6	-0.0	0.6	-0.4	1.0	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.2	7.4	0.2	2.7	-2.4	0.4	-2.2	2.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.9	0.4	-0.3	0.7	-0.3	0.2
Number of children fathered	1.4	1.6	4.1	-0.4	-0.6	1.2	-1.8	2.0	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.0	0.3	0.3	-0.6	-0.4	0.0
Age at first live birth	0.9	1.5	4.2	2.0	1.1	-0.5	0.2	-1.2	-1.4
Pulse wave peak to peak time	1.4	1.6	5.1	0.7	1.5	-0.8	0.9	-2.3	0.5
Health satisfaction	1.0	1.2	2.4	-0.4	-1.4	1.3	-0.8	1.6	-0.6
Shortness of breath walking on level ground	1.7	2.1	7.8	-1.7	-0.2	1.0	0.5	0.4	2.8
Qualifications: College or University degree	0.5	1.7	4.9	-0.1	2.0	-1.1	-0.4	-2.2	-0.2
Eye problems/disorders: None of the above	2.3	2.7	10.5	1.3	0.8	-1.1	3.2	-1.2	0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.5	-0.4	2.1	0.3	0.1	-0.3	1.5
Emphysema/chronic bronchitis	0.4	0.4	0.9	-0.3	-0.9	0.7	0.5	-0.1	-0.9
Medication for pain relief, constipation, heartburn	0.8	1.4	5.0	0.4	-1.3	1.1	-0.1	2.2	-0.8
Neck or shoulder pain in last month	0.7	1.0	2.5	1.6	-0.4	-0.9	0.7	-0.6	1.4
Medication: Blood pressure	1.9	3.3	5.3	-0.5	-2.1	1.7	-1.5	2.1	-2.3
Angina (self-reported)	0.7	1.0	2.0	1.4	1.0	-0.9	1.0	0.2	-1.0
Migraine (self-reported)	1.3	1.6	5.8	1.2	0.9	-2.4	0.8	-0.8	0.1
Medication: Ibuprofen	0.5	0.6	1.4	-1.0	1.0	0.4	-0.2	-1.2	0.3
Medication: Allopurinol	0.3	0.4	1.3	0.5	0.1	-1.1	0.8	-0.6	0.2
Medication: Omeprazole	0.4	0.4	1.1	-0.4	-0.4	0.2	1.1	1.0	-0.2
Medication: Seretide 50 evohaler	0.3	0.3	1.4	0.6	-0.1	-0.2	0.1	-0.0	1.2
Mean time to correctly identify matches	0.6	1.1	4.1	0.7	0.5	-2.0	-0.1	-1.2	0.6
Heart disease (mother)	3.9	4.8	8.9	-1.9	-1.3	2.8	-1.5	3.0	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.9	-0.1	-0.7	1.4	-1.2	0.8	-0.3
Whole body fat mass	0.6	2.6	10.1	-3.2	0.6	0.3	-2.1	0.4	0.6
Leg fat mass (right)	0.6	2.5	6.3	-2.5	1.2	-0.5	-2.5	0.3	0.7
Arm predicted mass (right)	0.5	2.4	5.3	-2.3	0.3	1.9	-2.0	0.9	0.8
Pulse rate, automated reading	1.6	5.1	15.5	0.7	2.4	-2.8	3.9	-0.3	0.8
Alcohol intake frequency.	0.1	0.3	0.9	0.5	-1.0	0.3	0.1	0.4	0.7
Comparative height size at age 10	0.3	1.7	4.2	-1.9	0.5	2.0	0.1	0.6	1.3
Number of full sisters	1.1	1.4	3.0	-1.0	-0.4	1.7	-1.0	1.7	-0.0
Suffer from ‘nerves’	1.2	2.0	3.7	0.6	1.8	-1.4	1.5	-0.4	1.9
Overall health rating	0.6	1.3	5.7	-0.2	-2.4	0.7	1.1	0.7	0.2
Chest pain or discomfort	0.2	0.2	0.6	-0.1	0.6	-0.2	-0.8	-0.1	-0.7
Had major operations	0.4	0.5	1.2	-1.1	-0.3	0.9	-0.4	-0.0	-0.7
Age at last live birth	0.4	0.6	1.0	1.0	0.5	-0.5	-0.9	-1.0	-0.5
Family relationship satisfaction	0.6	0.7	3.0	1.7	0.5	-0.4	0.7	-0.6	-0.1
Leg pain on walking	0.9	1.1	4.8	-2.2	1.0	0.2	-0.5	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	2.8	-1.6	1.3	1.1	-0.5	0.8	1.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	4.3	0.2	0.4	-0.2	-2.1	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.1	0.2	-1.0	1.0	-0.9	1.0	-1.1
Medication: Aspirin	1.2	1.6	3.3	-0.3	1.5	-0.5	-1.8	-1.2	-1.4
Supplements: Vitamin C	0.5	0.5	2.4	-0.4	1.5	0.8	-0.4	0.1	-0.1
Knee pain experienced in last month	0.8	1.2	2.3	-1.5	-1.2	1.1	-0.5	1.3	-0.5
Hypertension (Self-reported)	0.8	2.3	4.8	-0.2	-2.2	1.4	-1.3	1.7	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.5	1.6	0.1	-1.2	1.6	-0.2	-0.4
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.7	0.0	-1.1	0.5	-0.5	-0.3
Illnesses of siblings: Diabetes	1.4	1.7	3.5	-1.9	-0.7	1.5	0.1	1.7	-1.1
Smoking status: Previous	0.4	0.6	1.5	-0.1	0.8	-1.2	1.1	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.2	-0.1	0.6	-0.4	0.7	-0.3
Whole body fat-free mass	0.3	1.9	6.3	-2.5	0.2	1.6	-1.2	0.8	0.6
Leg fat-free mass (right)	0.3	1.5	7.8	-2.8	0.4	0.8	-0.6	-0.1	0.5
Arm fat percentage (left)	0.5	2.2	7.7	-2.8	0.6	-1.1	-1.8	-0.7	0.4
Average weekly red wine intake	0.7	1.0	3.0	0.1	1.7	-0.6	-0.1	-1.7	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	0.1	-0.9	-0.0	0.7	0.5	-1.5
Mood swings	0.7	1.3	3.0	-0.1	0.1	-1.5	0.6	-1.5	1.7
Loneliness, isolation	0.2	0.2	1.0	0.2	0.3	-0.3	0.1	-0.4	1.0
Long-standing illness, disability or infirmity	0.8	1.2	5.4	-2.3	-0.7	0.5	0.8	0.7	-0.4
Ever had bowel cancer screening	1.1	1.3	2.8	-0.6	-0.9	0.4	-1.7	1.4	-1.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.7	0.5	-0.2	0.7	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	4.9	1.8	0.6	-1.0	2.2	-1.7	0.0
Friendships satisfaction	0.3	0.3	0.6	0.8	0.4	-0.7	0.3	-0.8	0.2
Qualifications: nursing, teaching	0.9	1.5	4.4	-0.4	0.7	-0.0	-2.1	-1.7	0.9
Commuting to job workplace: Walk	1.2	1.3	4.7	-2.2	-1.2	-0.5	0.6	-0.4	1.0
Eye problems/disorders: Cataract	1.9	2.2	8.8	-0.0	1.3	0.0	-3.0	1.1	1.3
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	5.9	1.8	0.1	-2.1	2.4	-1.8	1.0
Medication for cholesterol	0.1	0.1	0.4	0.1	-0.0	0.4	0.1	0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	0.9	-0.6	0.8	0.5	0.7	-0.7
Back pain experienced in last month	0.4	0.5	1.6	-1.0	0.2	0.0	1.3	-0.4	0.5
Mineral and other dietary supplements	0.8	1.1	2.2	1.2	0.6	-1.1	1.5	0.0	1.2
Breast cancer (self-reported)	0.4	0.5	1.2	-0.1	1.1	-0.5	-1.0	0.1	-0.6
Asthma (self-reported)	0.3	0.5	1.7	0.1	-0.0	-1.3	-0.5	-0.8	-0.7
Osteoporosis (self-reported)	1.1	1.4	3.2	-1.2	-0.9	1.5	-0.8	0.4	-1.8
Osteoarthritis (self-reported)	1.2	1.5	6.0	-2.5	-0.4	-0.3	-1.5	-0.7	-0.1
Medication: Aspirin	1.0	1.3	3.8	-0.3	1.0	-0.0	-1.9	-1.0	-1.4
Medication: Gliclazide	1.7	1.9	5.8	-2.4	0.9	1.9	-0.4	1.0	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.4	1.1	-0.7	-0.0	-1.2	0.1
Smoking status: Current	1.0	1.6	7.0	-1.2	-0.2	1.0	-0.2	-0.3	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.9	1.7	0.6	-1.3	-1.0	-2.0	0.9
Whole body water mass	0.3	2.0	6.9	-2.6	0.3	1.5	-1.3	0.6	0.8
Leg predicted mass (right)	0.3	1.6	8.1	-2.8	0.4	0.8	-0.6	-0.1	0.6
Arm fat mass (left)	0.5	2.2	8.9	-3.0	0.3	-0.1	-1.9	0.0	0.5
Number of self-reported non-cancer illnesses	0.5	0.8	2.9	-1.2	0.3	0.0	-1.7	0.4	-0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-0.4	1.0	-0.8	0.9	-1.0	-0.2
Miserableness	0.3	0.5	1.2	0.4	-1.1	0.2	0.7	0.7	0.9
Guilty feelings	0.8	1.2	2.0	0.5	-1.1	-0.9	1.1	-1.4	1.4
Wears glasses or contact lenses	1.4	1.6	3.0	-1.3	-0.9	1.7	-0.4	1.6	-1.2
Ever taken oral contraceptive pill	0.2	0.2	1.0	-0.0	-0.2	0.6	0.1	-0.3	-1.0
Hearing aid user	0.3	0.3	1.1	-0.7	-0.4	0.0	0.1	-0.1	1.0
Mother’s age at death	0.7	0.8	1.7	1.1	-1.3	-1.1	0.8	0.2	0.4
Financial situation satisfaction	0.5	0.7	1.2	0.6	-1.1	0.0	0.3	-1.1	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.7	0.1	-0.6	-0.5	-0.9	-0.0
Commuting to job workplace: Public transport	1.4	1.7	2.8	-1.1	-1.2	1.5	0.3	1.4	-1.7
Eye problems/disorders: Glaucoma	3.1	3.7	6.2	-2.1	-1.9	1.4	-2.5	1.3	-2.1
Medication: Blood pressure	0.3	0.5	2.0	0.9	0.1	-0.4	-1.4	0.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	0.5	0.1	0.1	-0.5	-1.0	0.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.8	-1.6	-0.6	1.2	-1.7	0.5	-1.5
High cholesterol (Self-reported)	0.7	1.2	2.3	-1.0	-0.7	1.0	-0.9	1.5	-1.1
Medication: Bendroflumethiazide	0.4	0.7	2.7	-0.4	-0.9	0.4	-1.6	0.3	0.0
Medication: Paracetamol	0.5	0.8	1.5	-0.5	0.8	-1.0	-0.9	-1.2	0.8
Medication: Lisinopril	0.8	1.1	4.5	2.1	-1.0	-0.6	0.3	0.7	0.0
Medication: Atorvastatin	1.1	1.3	4.2	-0.6	-0.2	2.0	0.4	1.6	-0.9
Illnesses of father: High blood pressure	2.7	3.4	8.1	-1.0	-1.3	1.5	-2.0	1.8	-2.8
Alcohol drinker status: Never	0.5	0.6	1.3	-0.7	-0.8	0.6	-1.1	0.7	0.3
Ever smoked	0.8	1.3	2.7	0.2	0.5	-1.6	1.2	-1.1	1.6
Basal metabolic rate	0.4	2.2	7.8	-2.8	0.3	1.5	-1.4	0.7	0.6
Leg fat percentage (left)	0.8	3.0	7.7	-2.4	1.6	-1.2	-2.8	0.0	0.6
Arm fat-free mass (left)	0.5	2.6	6.9	-2.6	0.2	1.9	-1.8	1.1	0.5
Number of operations (self-reported)	1.0	1.5	6.7	-2.6	0.6	0.5	-1.0	0.4	0.7
Average weekly beer plus cider intake	0.7	1.1	5.0	0.8	-2.2	0.6	0.6	0.2	0.2
Irritability	0.8	1.3	2.7	1.6	-1.1	-0.7	1.5	-0.2	1.2
Risk taking	1.6	2.3	5.9	-0.4	1.9	-1.2	0.3	-1.6	2.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.5	-0.9	-0.9	1.4	-1.6	1.9	-0.2
Fractured/broken bones in last 5 years	1.8	2.4	7.4	-1.8	0.4	-0.1	-2.7	-1.2	1.3
Age started oral contraceptive pill	0.5	0.6	2.5	-0.9	-0.1	0.4	-1.6	0.3	0.3
Diastolic blood pressure, automated reading	0.5	1.6	6.0	0.4	-2.4	0.0	0.9	1.2	-1.2
Ever depressed for a whole week	0.7	0.9	3.6	-0.4	0.2	-0.8	0.8	-1.9	0.4
Unable to work because of sickness or disability	0.7	0.9	2.3	-0.7	-0.5	1.5	0.3	0.1	-1.4
Commuting to job workplace: Cycle	0.8	0.9	2.5	0.4	1.6	-1.0	1.1	-0.8	-0.0
Myopia	0.6	0.9	2.9	0.2	0.1	-0.5	0.8	1.1	-1.7
Vascular/heart problems diagnosed by doctor	1.0	2.6	4.8	0.2	1.6	-1.6	1.8	-1.6	2.2
Cholesterol lowering medication	0.1	0.2	0.9	0.3	-0.3	0.1	-0.3	0.9	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.2	-0.5	0.3	1.1	0.8	0.2
Pain experienced in last month	0.1	0.2	0.3	0.4	-0.6	0.6	0.5	0.6	0.4
Supplements: Calcium	0.5	0.5	1.9	0.8	0.0	0.6	-0.5	-0.0	-1.4
Basal cell carcinoma (self-reported)	0.9	1.1	3.8	-1.2	1.0	1.9	-0.1	-0.0	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.6	-0.6	1.0	0.5	-0.8	1.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.0	0.1	-0.3	-0.3	-1.4	-0.0	0.3
Heart disease (siblings)	0.9	1.2	3.4	-0.8	-0.5	0.9	-1.8	1.4	0.1
Alcohol drinker status: Previous	1.1	1.3	2.7	0.1	-1.3	0.9	0.1	1.5	1.6
Pack years of smoking	0.9	1.3	2.3	1.5	1.0	-1.5	0.9	-0.7	0.9
Impedance of whole body	0.2	0.9	3.1	0.9	1.1	0.1	1.8	0.0	0.1
Leg fat mass (left)	0.8	3.1	8.2	-2.9	1.5	-0.4	-2.7	0.1	0.8
Arm predicted mass (left)	0.6	3.1	8.2	-2.9	0.2	2.2	-1.8	1.4	0.4