Hub : Genes

PADI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0530	0.0250	0.00130	0.016	0.015	0.031	NA	0.023	6.1e-03	0.00730	0.00019	NA	0.00120
2	TCGA	Brain Lower Grade Glioma	0.0446	0.0215	0.00240	0.034	0.020	0.030	NA	0.028	9.4e-05	0.00220	0.00021	NA	0.00034
3	TCGA	Lung Adenocarcinoma	0.0693	0.0281	0.00045	0.007	0.030	0.015	NA	0.017	5.0e-02	0.00018	0.00670	NA	0.00410

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.3	0.1	0.2	1.2
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	0.9	0.5	1.9
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	0.8	-1.0	1.4
Depression (Nagel 2018)	1.4	2.2	2.7	1.5	-1.7	1.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.2	0.0	0.5
Neuroticism (Nagel 2018)	0.7	1.5	2.1	1.1	-1.1	1.5
Schizophrenia (2018)	0.6	1.3	2.3	1.1	0.5	1.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.5	1.1	-0.3
Worry (Nagel 2018)	0.2	0.4	0.9	0.3	-1.0	0.5
Alzheimer’s Disease (in mother)	2.0	2.4	3.5	1.1	-1.9	1.6
Alzheimer’s Disease (in father)	0.5	0.6	1.2	-1.1	0.2	-0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	0.0	-1.2	0.7
Crohns Disease (2017)	0.1	0.3	0.5	0.5	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.8	1.8	2.6	1.6	-1.4	-0.9
Ulcerative Colitis (UC)	1.6	3.0	5.2	2.3	-2.0	-0.2
Major Depression (MDD)	0.4	0.4	0.9	1.0	-0.4	0.5
Reaction Time	1.3	2.4	4.0	-1.8	2.0	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	0.8	0.9	-0.8	0.8
Breast Cancer	0.8	1.9	5.3	0.6	-0.3	2.3
Ovarian Cancer	2.1	2.8	3.0	1.7	-1.7	1.6
Prostate Cancer	1.6	2.3	5.9	0.7	-0.7	2.4
Age at First Birth	0.5	0.8	0.8	0.9	-0.9	0.9
Bipolar Disorder (2011)	1.6	1.6	2.5	1.6	-1.4	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	0.9	-0.4	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.3	0.4	-0.6	0.5
Crohns Disease (2012)	1.1	1.7	3.8	1.9	-1.1	0.2
Mean Putamen Volume	0.3	0.3	0.6	-0.8	0.5	-0.0
Fasting Glucose	0.4	0.5	0.6	-0.7	0.8	0.5
HbA1C	0.1	0.1	0.2	0.5	0.2	0.4
HDL Cholesterol	0.1	0.2	0.5	0.2	0.7	0.4
LDL Cholesterol	0.2	0.3	0.6	0.3	-0.8	0.4
Lupus	0.3	0.5	0.7	-0.7	-0.4	-0.9
Neuroticism (2016)	1.4	2.0	2.4	1.5	-1.2	1.6
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	-0.1	-0.0
Rheumatoid Arthritis	0.8	1.1	1.9	0.8	-0.9	1.4
Schizophrenia (2014)	0.4	0.9	1.2	0.8	0.9	1.1
Triglycerides	0.3	0.5	1.1	-1.0	-0.2	-0.7
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.1	1.4	-0.9	1.4
Ulcerative Colitis	1.8	2.6	5.0	2.2	-1.5	-0.5
Blood Eosinophil Count	0.1	0.6	1.3	-0.2	0.7	1.1
Blood Platelet Count	0.0	0.3	0.7	-0.4	0.3	-0.9
Blood Red Count	0.4	4.1	6.0	2.1	-2.5	1.3
Blood White Count	0.2	1.1	2.8	0.6	-1.7	-0.5
Heel T-Score	0.3	2.0	3.0	1.4	-1.0	1.7
BMI	0.0	0.0	0.1	0.0	0.2	0.1
Height	0.0	0.1	0.3	-0.4	-0.0	0.5
Waist Hip Ratio (WHR)	0.3	1.5	2.4	1.6	-0.5	1.3
Systolic Blood Pressure	0.2	1.1	1.3	-1.1	1.1	-0.9
Smoking Status	0.3	0.6	1.0	-0.3	1.0	-0.8
Allergy or Eczema	0.2	0.6	0.8	-0.9	0.9	-0.4
Cardiovascular Disease	0.1	0.2	0.4	0.2	0.4	-0.7
Hypothyroidism (self reported)	1.1	2.5	3.7	-1.3	1.9	-1.4
Respiratory disease	1.2	2.7	6.3	1.0	-0.9	2.5
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	0.3	0.8	-0.4
Lung FEV1/FVC ratio	2.4	12.3	16.3	-4.0	3.2	-3.2
Lung FVC	0.2	0.8	2.4	0.0	-0.2	-1.5
Neuroticism	0.3	0.8	1.0	0.8	-0.9	1.0
Chronotype (morning person)	0.3	0.7	1.1	-0.8	0.5	-1.1
Hair Pigment	0.7	19.3	38.6	-3.8	6.2	-2.2
Tanning	0.5	5.5	10.2	3.2	-2.5	0.4
Hand grip strength (left)	0.0	0.1	0.3	-0.1	0.6	0.2
Number of treatments/medications taken	1.8	3.2	3.8	1.9	-1.5	1.9
Average weekly spirits intake	1.2	1.4	2.7	-1.3	1.6	0.1
Sensitivity / hurt feelings	0.6	1.0	1.5	1.2	-1.1	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.4	-0.3	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-1.1	0.8	-0.0
Relative age of first facial hair	0.1	0.2	0.6	0.4	-0.8	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.8	-0.7	0.5
Ever used hormone-replacement therapy (HRT)	2.1	2.7	5.7	2.4	-1.3	0.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	0.9	-1.4	0.1
Systolic blood pressure, automated reading	0.7	1.9	2.9	-1.7	1.7	-0.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.7	-0.7	1.1	-1.6
Angina	2.3	3.0	4.5	1.6	-2.1	1.4
Medication for hormone replacement therapy	0.4	0.4	0.7	0.8	0.1	0.9
Vitamin and mineral supplements	1.1	1.5	2.3	-1.5	1.2	-0.9
Supplements: Zinc	0.2	0.2	0.4	0.6	0.6	0.1
Medication: Co-codamol	2.0	2.3	4.3	1.1	-1.1	2.1
Medication: Metformin	1.0	1.4	3.4	1.8	-0.9	-0.1
Diabetes (father)	0.2	0.2	0.5	-0.4	0.7	0.2
Diabetes (mother)	1.3	1.7	3.1	1.0	-1.0	1.8
Severe depression (siblings)	0.2	0.2	0.4	0.2	0.4	0.6
Pack years adult smoking proportion	0.7	1.0	3.0	-0.2	-0.1	1.7
Impedance of leg (right)	0.4	2.1	2.3	1.4	-1.5	1.4
Leg fat-free mass (left)	0.3	1.6	2.9	-1.2	1.7	-0.7
Trunk fat percentage	1.2	4.9	5.5	2.3	-2.4	1.9
Hand grip strength (right)	0.3	0.8	1.3	1.2	-0.4	1.0
Townsend deprivation index at recruitment	1.0	1.4	1.9	-1.4	0.6	-1.4
Current tobacco smoking	0.4	0.6	1.1	0.8	-1.0	0.2
Average weekly fortified wine intake	0.2	0.3	0.7	0.2	-0.9	0.3
Maternal smoking around birth	2.4	3.5	6.6	2.6	-1.2	1.6
Fed-up feelings	0.2	0.4	0.7	0.3	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.2	1.8	-1.2	1.2
Relative age voice broke	0.9	1.3	1.4	1.2	-1.2	1.1
Taking other prescription medications	1.1	1.7	2.1	1.2	-1.2	1.4
Age when periods started (menarche)	0.7	1.8	2.5	-0.9	1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.2	1.5	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.8	1.8	-1.1	2.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.0	-0.2	-0.2
Qualifications: CSEs or equivalent	1.9	2.5	3.9	-1.5	1.2	-2.0
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.8	-0.7	0.1
High blood pressure	0.5	1.4	3.4	-0.5	0.7	-1.9
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.5	-0.1	-0.7
Multivitamins +/- minerals	1.0	1.3	2.5	1.2	-0.2	1.6
Stomach or abdominal pain in last month	1.6	2.0	2.4	1.4	-1.5	1.3
Supplements: Glucosamine	1.9	2.5	4.7	-0.7	1.5	-2.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.8	0.3	-0.1
Medication: Atenolol	1.0	1.3	2.4	-0.5	1.1	-1.5
Medication: Levothyroxine sodium	0.4	0.7	1.0	-0.8	1.0	-0.7
Sitting height	0.3	2.4	4.0	-1.7	2.0	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.5	0.2	-0.6
High blood pressure (mother)	0.2	0.3	0.8	0.1	-0.2	-0.9
Body mass index (BMI)	0.1	0.6	1.1	1.1	-0.7	0.4
Impedance of leg (left)	0.8	4.0	4.9	2.1	-2.2	1.7
Leg predicted mass (left)	0.2	1.3	2.4	-1.0	1.6	-0.7
Trunk fat mass	0.6	2.6	3.0	1.7	-1.5	1.6
Waist circumference	0.1	0.3	0.5	0.7	-0.2	0.5
Number of incorrect matches in round	0.0	0.1	0.1	-0.2	-0.4	-0.1
Past tobacco smoking	1.0	1.9	2.9	0.4	-1.6	1.7
Alcohol usually taken with meals	0.5	0.8	2.5	0.2	0.1	1.6
Nervous feelings	0.1	0.2	0.3	-0.6	-0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.3	0.2	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.0	-0.3	0.9
Hair/balding pattern: Pattern 2	0.9	1.2	2.7	0.9	-0.2	1.7
Had menopause	0.1	0.1	0.2	0.3	-0.2	0.4
Had other major operations	1.7	2.1	4.2	2.0	-1.4	0.4
Forced vital capacity (FVC)	0.0	0.2	0.3	0.0	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	3.4	1.9	-1.4	1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	-0.7	0.1	0.4
Qualifications: None of the above	0.5	1.1	2.4	1.6	-0.8	0.6
Financial difficulties in last 2 years	0.3	0.5	0.9	1.0	-0.3	0.6
Mouth/teeth dental problems	0.8	1.3	2.1	-1.5	0.8	-1.0
Heart attack	0.9	1.2	1.4	1.2	-1.0	1.0
Allergy	0.1	0.2	0.3	0.2	0.5	-0.4
Pain all over the body in last month	1.1	1.2	2.2	-1.1	0.1	-1.5
Diabetes (self-reported)	0.2	0.3	0.7	-0.0	0.8	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	0.2	0.4	1.4
Medication: Ramipril	0.5	0.7	1.4	0.5	0.6	-1.2
Medication: Simvastatin	1.3	1.9	3.1	1.8	-1.4	0.7
Fluid intelligence score	0.4	0.8	1.1	0.8	-0.8	1.1
Illnesses of siblings	0.9	1.2	3.2	-0.6	0.3	-1.8
Neuroticism score	0.3	0.6	1.1	0.7	-1.1	0.5
Weight	0.0	0.1	0.2	0.4	0.0	0.5
Impedance of arm (right)	0.5	2.3	3.0	1.3	-1.7	1.5
Arm fat percentage (right)	0.9	3.5	4.5	2.1	-1.9	1.6
Trunk fat-free mass	0.3	1.6	3.1	-0.9	1.8	-0.8
Hip circumference	0.0	0.1	0.2	-0.0	0.0	-0.4
Time employed in main current job	0.6	0.7	1.2	-1.1	0.8	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	1.4	1.2	-0.2	0.2
Father’s age at death	1.5	2.1	3.8	-1.9	1.4	-0.8
Worrier / anxious feelings	0.1	0.1	0.3	-0.6	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	0.9	-1.1	0.1
Falls in the last year	0.6	0.7	1.0	-1.0	-0.6	-0.9
Hair/balding pattern: Pattern 3	0.3	0.5	0.7	-0.6	0.8	-0.7
Number of live births	1.3	1.8	2.3	1.4	-1.0	1.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	2.6	-1.1	1.5	-1.6
Pulse rate	0.2	0.4	1.1	-1.0	0.2	0.1
Happiness	0.2	0.3	0.4	0.6	-0.5	0.5
Noisy workplace	0.3	0.3	0.9	0.1	-0.2	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.9	0.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	0.5	-0.2	0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	0.0	0.2	1.2
Asthma	0.6	1.2	3.2	0.5	-0.2	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.5	-0.6	-0.7	-0.7
Medication: Cholesterol lowering	0.9	1.4	2.3	1.5	-1.4	0.1
Depression (self-reported)	0.1	0.2	0.4	0.2	-0.6	-0.1
Medication: Lansoprazole	2.1	2.4	3.6	1.9	-1.0	1.6
Prospective memory result	3.6	4.4	5.3	-2.1	2.3	-1.9
Lung cancer (father)	1.9	2.3	2.7	-1.6	1.4	-1.5
Illnesses of mother	0.0	0.0	0.0	-0.0	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	6.1	-1.7	2.1	-2.5
Pulse wave Arterial Stiffness index	2.6	3.0	3.5	1.6	-1.7	1.9
Impedance of arm (left)	0.8	3.8	5.3	1.7	-2.3	1.8
Arm fat mass (right)	0.2	1.0	1.5	1.2	-0.8	0.9
Trunk predicted mass	0.3	1.6	3.1	-0.9	1.8	-0.8
Standing height	0.1	1.1	2.1	-1.1	1.4	0.1
Length of working week for main job	1.0	1.1	1.8	-1.3	0.8	-0.9
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.5	0.1	-0.2
Breastfed as a baby	0.3	0.3	0.9	-0.2	0.3	-1.0
Tense / ‘highly strung’	0.2	0.4	1.2	0.1	0.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.4	1.6	-1.0	0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.4	0.5	0.9
Birth weight of first child	0.1	0.2	0.3	0.0	0.5	0.5
Peak expiratory flow (PEF)	0.2	0.4	0.6	-0.3	0.6	-0.8
Pulse wave reflection index	0.5	0.6	1.6	0.5	0.3	1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	-0.7	0.7	0.3
Loud music exposure frequency	1.3	1.4	3.6	0.7	-1.9	0.3
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	3.9	-2.0	1.6	-1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	1.6	1.3	-1.1	1.0
Blood clot in the leg (DVT)	1.5	1.9	3.3	1.4	-1.8	0.6
Medication: Paracetamol	0.6	0.9	1.9	0.5	-0.8	1.4
Headache pain in last month	1.5	2.6	5.8	1.2	-0.6	2.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.2	-1.5	0.7	0.3
Glaucoma (self-reported)	1.2	1.5	2.8	-1.7	1.1	-0.6
Gout (self-reported)	0.5	0.7	1.6	-1.3	0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.6	-0.7	1.6	-0.5
Medication: Amlodipine	0.3	0.5	0.9	-0.4	0.9	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.2	0.1	0.8
Birth weight	0.3	0.6	0.8	-0.5	0.9	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.6	-0.9	0.6	-1.3
High blood pressure (siblings)	0.3	0.4	1.2	-0.3	0.1	1.1
Forced vital capacity (FVC), Best measure	0.5	1.8	2.9	-0.9	1.3	-1.7
Body fat percentage	1.3	5.3	6.2	2.5	-2.3	2.1
Leg fat percentage (right)	1.2	4.5	5.3	2.3	-1.8	2.2
Arm fat-free mass (right)	0.3	1.7	2.9	-1.0	1.7	-1.0
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.1	0.3	0.3
Comparative body size at age 10	0.5	1.3	2.2	-1.5	0.4	-1.2
Number of full brothers	2.1	2.6	4.2	-1.0	1.6	-2.0
Worry too long after embarrassment	1.4	2.4	3.0	1.7	-1.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	-0.4	0.1
Wheeze or whistling in the chest in last year	2.3	4.1	5.2	2.3	-2.1	1.6
Number of children fathered	0.7	0.8	1.0	0.7	-1.0	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.7	0.1	1.3	-0.5
Age at first live birth	0.2	0.3	0.5	0.6	-0.3	0.7
Pulse wave peak to peak time	2.0	2.3	2.8	-1.4	1.5	-1.7
Health satisfaction	1.1	1.4	2.4	1.1	-0.8	1.6
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.4	0.1	-0.3
Qualifications: College or University degree	0.1	0.3	0.7	-0.2	-0.3	0.9
Eye problems/disorders: None of the above	0.4	0.4	0.8	0.9	-0.7	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.6	-0.5	0.0
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.7	0.2	0.6
Medication for pain relief, constipation, heartburn	0.9	1.5	2.0	-1.2	1.4	-0.9
Neck or shoulder pain in last month	0.9	1.3	2.8	0.9	-1.7	-0.6
Medication: Blood pressure	0.3	0.5	1.3	1.1	0.2	-0.1
Angina (self-reported)	2.1	2.7	3.8	1.6	-1.9	1.4
Migraine (self-reported)	0.2	0.3	0.5	-0.3	0.6	0.7
Medication: Ibuprofen	0.8	0.9	1.0	-0.9	-1.0	-1.0
Medication: Allopurinol	0.3	0.4	0.8	-0.3	-0.9	-0.6
Medication: Omeprazole	0.2	0.2	0.5	0.1	-0.7	-0.0
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.8	0.1	-0.4
Mean time to correctly identify matches	0.6	1.1	2.1	-1.1	1.5	0.1
Heart disease (mother)	0.2	0.3	0.8	-0.0	-0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	-0.1	1.1	-0.5
Whole body fat mass	0.5	1.9	2.3	1.5	-1.2	1.4
Leg fat mass (right)	0.3	1.1	1.5	1.1	-0.7	1.2
Arm predicted mass (right)	0.2	1.0	2.1	-0.7	1.4	-0.7
Pulse rate, automated reading	0.2	0.6	1.1	0.6	-1.1	0.6
Alcohol intake frequency.	0.4	0.9	1.4	1.0	-0.5	1.2
Comparative height size at age 10	0.1	0.5	0.7	-0.9	0.4	0.7
Number of full sisters	0.1	0.1	0.2	-0.0	-0.0	0.5
Suffer from ‘nerves’	0.0	0.1	0.1	0.1	-0.4	-0.2
Overall health rating	0.7	1.6	2.0	1.3	-1.4	1.1
Chest pain or discomfort	1.0	1.4	2.4	0.9	-1.1	1.5
Had major operations	0.5	0.6	0.7	0.9	-0.8	0.7
Age at last live birth	0.2	0.3	0.3	0.5	-0.5	0.5
Family relationship satisfaction	1.2	1.5	2.5	-1.6	1.4	0.1
Leg pain on walking	0.5	0.6	0.8	0.7	-0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.7	-1.6	0.7	-1.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.2	0.7	-0.2	2.1
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.1	-2.0	0.8	-1.1
Medication: Aspirin	0.3	0.4	1.2	1.1	-0.2	-0.2
Supplements: Vitamin C	1.4	1.6	4.0	2.0	-0.7	0.5
Knee pain experienced in last month	0.8	1.2	2.2	-0.5	1.0	-1.5
Hypertension (Self-reported)	0.6	1.7	4.0	-0.7	0.8	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.2	-0.3	-0.2
Illnesses of father: Heart disease	1.1	1.6	1.7	1.2	-1.3	1.3
Illnesses of siblings: Diabetes	1.7	2.1	3.0	-1.5	1.7	-1.0
Smoking status: Previous	0.7	1.0	2.5	-0.3	1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.7	-2.2	2.0	-1.4
Whole body fat-free mass	0.2	1.4	2.7	-0.9	1.6	-0.8
Leg fat-free mass (right)	0.2	1.2	2.2	-1.0	1.5	-0.7
Arm fat percentage (left)	1.0	3.9	4.9	2.2	-2.0	1.7
Average weekly red wine intake	0.6	0.9	2.2	0.3	0.6	1.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	0.4	-0.0
Mood swings	0.2	0.4	1.1	0.5	-1.0	0.1
Loneliness, isolation	0.7	1.0	1.7	-1.3	1.1	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.1	0.3	-0.4	-0.3
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.2	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.5	0.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	4.1	4.4	6.1	2.1	-2.5	1.5
Friendships satisfaction	1.4	1.7	3.6	0.9	-0.9	1.9
Qualifications: nursing, teaching	0.5	0.7	2.1	-0.1	-0.1	1.4
Commuting to job workplace: Walk	0.7	0.7	1.1	-1.0	0.8	-0.7
Eye problems/disorders: Cataract	0.5	0.6	1.3	-1.2	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	0.5	0.2	-0.9
Medication for cholesterol	0.5	0.7	1.3	0.6	-1.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.8	0.4	0.6
Back pain experienced in last month	0.6	0.9	1.3	1.0	-0.5	1.2
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	0.2	0.5
Breast cancer (self-reported)	0.0	0.0	0.1	0.1	0.0	-0.3
Asthma (self-reported)	0.6	1.2	2.9	0.6	-0.6	1.7
Osteoporosis (self-reported)	0.0	0.0	0.0	0.2	0.2	0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	0.4	0.0
Medication: Aspirin	0.3	0.4	0.9	1.0	-0.2	-0.4
Medication: Gliclazide	0.3	0.4	0.7	0.7	0.8	-0.1
Illnesses of father: None of the above (group 1)	1.8	2.2	4.1	-1.6	2.0	0.3
Smoking status: Current	0.2	0.3	0.5	0.6	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.8	-0.9	0.5	-1.7
Whole body water mass	0.3	1.5	2.6	-1.0	1.6	-0.9
Leg predicted mass (right)	0.2	1.2	2.2	-1.0	1.5	-0.7
Arm fat mass (left)	0.3	1.4	2.0	1.4	-1.1	1.0
Number of self-reported non-cancer illnesses	1.2	2.1	3.1	1.8	-0.8	1.6
Average weekly champagne plus white wine intake	0.4	0.6	0.6	-0.8	0.8	-0.7
Miserableness	0.1	0.1	0.2	0.4	0.1	-0.3
Guilty feelings	0.3	0.4	0.8	0.6	-0.2	0.9
Wears glasses or contact lenses	0.5	0.6	1.3	-0.7	1.1	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.6	0.0	-0.2
Hearing aid user	0.9	1.1	2.0	1.1	-1.4	0.1
Mother’s age at death	0.2	0.2	0.3	-0.5	0.5	-0.2
Financial situation satisfaction	0.0	0.0	0.1	0.3	-0.1	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	0.6	-0.8	0.3
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.3	-0.4	-0.6
Eye problems/disorders: Glaucoma	4.8	5.7	9.4	-3.1	2.1	-1.8
Medication: Blood pressure	0.2	0.3	0.7	0.4	0.3	-0.8
Pain type(s) experienced in last month: Hip pain	3.6	4.5	6.2	2.5	-2.3	1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	1.1	-0.7	0.7
High cholesterol (Self-reported)	0.5	0.9	1.5	1.2	-1.1	-0.1
Medication: Bendroflumethiazide	0.2	0.2	0.6	0.3	0.8	-0.3
Medication: Paracetamol	0.4	0.6	0.9	-0.1	-0.9	1.0
Medication: Lisinopril	0.7	1.0	1.3	1.1	-1.1	0.7
Medication: Atorvastatin	0.0	0.0	0.0	0.2	0.0	-0.1
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.4	-0.4	-0.5
Alcohol drinker status: Never	0.3	0.4	0.9	0.4	-0.9	-0.4
Ever smoked	0.6	1.0	2.7	-0.1	0.4	-1.7
Basal metabolic rate	0.1	0.8	1.7	-0.6	1.3	-0.5
Leg fat percentage (left)	1.7	6.3	7.9	2.8	-2.2	2.4
Arm fat-free mass (left)	0.2	0.9	1.5	-0.8	1.2	-0.8
Number of operations (self-reported)	0.6	0.9	1.3	0.7	-1.1	1.0
Average weekly beer plus cider intake	0.2	0.4	0.7	0.3	-0.8	-0.5
Irritability	0.6	1.1	1.7	-0.9	0.9	-1.3
Risk taking	0.5	0.7	1.6	1.3	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	2.8	3.2	6.2	1.4	-2.5	1.2
Fractured/broken bones in last 5 years	0.5	0.7	1.9	0.5	-0.1	1.4
Age started oral contraceptive pill	0.5	0.6	0.9	-0.9	0.4	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	2.1	-1.5	0.9	0.0
Ever depressed for a whole week	0.5	0.7	1.4	0.6	-0.4	1.2
Unable to work because of sickness or disability	1.8	2.3	3.5	1.3	-1.9	1.3
Commuting to job workplace: Cycle	0.8	1.0	2.6	-0.2	0.7	-1.6
Myopia	0.0	0.1	0.1	0.3	-0.3	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.2	-0.0	-0.2	1.1
Cholesterol lowering medication	0.4	0.6	1.4	1.2	-0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.9	1.2	-1.7	0.9
Pain experienced in last month	0.6	1.1	2.1	-0.8	1.5	-0.6
Supplements: Calcium	0.2	0.2	0.5	-0.1	-0.0	0.7
Basal cell carcinoma (self-reported)	1.0	1.2	2.5	0.9	-1.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.1	1.0	-0.9	0.9
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.9	1.5	-1.7	0.4
Heart disease (siblings)	0.6	0.7	1.1	1.1	-1.0	0.1
Alcohol drinker status: Previous	0.8	0.9	2.6	0.2	0.3	1.6
Pack years of smoking	0.8	1.2	3.5	-0.1	-0.2	1.9
Impedance of whole body	0.7	3.8	5.3	1.7	-2.3	1.8
Leg fat mass (left)	0.4	1.4	1.8	1.3	-0.9	1.3
Arm predicted mass (left)	0.2	1.0	1.9	-0.7	1.4	-0.7