Hub : Genes

CLCNKB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0375	0.0178	2.3e-03	0.011	0.006	0.009	0.01	0.009	1.5e-04	4.2e-03	4.5e-04	0.00023	3.6e-04
2	TCGA	Pancreatic Adenocarcinoma	0.1810	0.0730	4.2e-04	0.032	0.038	0.010	NA	0.003	1.8e-02	1.0e-02	1.2e-01	NA	2.3e-01
3	TCGA	Prostate Adenocarcinoma	0.0322	0.0181	7.7e-03	0.026	0.009	0.013	NA	0.014	7.9e-04	3.2e-02	1.3e-02	NA	1.1e-02
4	TCGA	Thyroid Carcinoma	0.0950	0.0370	7.9e-06	0.058	0.069	0.059	NA	0.059	2.7e-06	3.0e-07	2.0e-06	NA	1.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.5	0.5	-0.1	-0.7	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	2.7	-0.6	0.8	-0.5	1.6
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	-1.2	0.6	0.6	0.4
Depression (Nagel 2018)	0.6	0.9	1.7	-0.1	1.2	-0.7	1.3
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.7	-1.1	2.0	2.6	-0.3
Neuroticism (Nagel 2018)	0.5	1.2	2.6	0.0	1.3	1.6	0.7
Schizophrenia (2018)	0.9	1.8	3.4	-1.2	1.5	-0.1	1.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.2	0.4	-0.4	-0.0
Worry (Nagel 2018)	1.4	2.9	4.2	0.9	2.0	1.6	2.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.2	0.4	-0.2	0.5
Alzheimer’s Disease (in father)	1.5	1.6	5.0	-0.0	-2.2	-1.1	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.1	-0.6	-0.5	0.1
Crohns Disease (2017)	1.8	3.9	7.8	2.5	-1.0	-2.8	0.6
Irritable Bowel Disease (IBD)	0.9	2.2	4.0	1.8	-1.1	-2.0	-0.7
Ulcerative Colitis (UC)	0.8	1.6	3.2	0.2	-1.3	-1.1	-1.8
Major Depression (MDD)	0.2	0.2	0.5	0.7	0.3	-0.4	0.1
Reaction Time	1.0	2.0	4.7	0.6	-2.2	-1.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.6	-1.9	1.5	1.5	0.0
Breast Cancer	0.3	0.6	1.3	-0.7	-0.5	-1.1	-0.6
Ovarian Cancer	3.1	4.0	9.0	2.1	-1.6	-3.0	0.1
Prostate Cancer	4.0	5.6	11.2	2.6	3.3	1.2	1.8
Age at First Birth	0.7	1.0	3.3	-0.8	0.2	-0.4	1.8
Bipolar Disorder (2011)	0.1	0.1	0.5	0.7	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	1.6	-0.5	-0.2	-1.4
Coronary Artery Disease (CAD)	1.2	1.4	3.5	-0.9	1.1	0.4	1.9
Crohns Disease (2012)	1.2	1.9	6.2	2.5	0.5	-0.9	0.4
Mean Putamen Volume	0.7	0.8	1.4	1.0	0.7	-1.2	0.6
Fasting Glucose	0.9	1.1	2.4	-1.6	-0.2	1.3	0.5
HbA1C	1.7	1.9	3.8	-1.1	-1.6	-0.0	-2.0
HDL Cholesterol	0.8	1.4	2.8	-0.2	1.7	1.5	0.7
LDL Cholesterol	0.2	0.3	0.5	-0.6	0.4	0.7	0.2
Lupus	1.1	1.7	3.8	-1.3	1.1	-0.3	1.9
Neuroticism (2016)	0.9	1.3	2.6	-0.8	1.2	0.8	1.6
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.4	0.4	0.5	0.9
Rheumatoid Arthritis	0.2	0.2	0.7	-0.1	0.1	-0.3	0.8
Schizophrenia (2014)	0.6	1.2	2.0	-0.2	0.9	-1.4	1.4
Triglycerides	0.1	0.2	0.7	0.1	-0.8	0.5	0.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.1	1.3	0.3	2.0	0.5
Ulcerative Colitis	0.6	0.8	1.6	0.9	0.4	1.2	-0.8
Blood Eosinophil Count	0.3	2.3	4.8	2.2	2.0	-0.3	0.2
Blood Platelet Count	0.0	0.2	0.7	-0.2	-0.0	-0.8	-0.3
Blood Red Count	2.6	24.9	76.2	-3.6	2.1	8.7	-2.5
Blood White Count	0.4	3.0	6.1	2.1	1.1	2.5	-0.6
Heel T-Score	1.7	13.5	31.0	-2.1	-4.3	-5.6	0.5
BMI	0.2	1.3	4.0	-0.3	-0.3	-2.0	1.1
Height	0.0	0.7	2.6	0.0	1.6	0.4	0.1
Waist Hip Ratio (WHR)	1.6	7.3	13.0	-1.0	2.6	3.6	2.9
Systolic Blood Pressure	1.6	7.9	19.7	-4.4	1.5	3.1	0.6
Smoking Status	0.7	1.7	3.1	1.2	1.5	-0.1	1.8
Allergy or Eczema	2.9	7.6	14.1	0.6	3.8	3.1	2.6
Cardiovascular Disease	2.1	6.9	15.2	-3.9	1.1	3.3	-0.5
Hypothyroidism (self reported)	0.8	1.9	2.4	1.0	1.5	-1.6	1.3
Respiratory disease	0.6	1.4	2.8	-1.7	-1.0	0.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.8	-1.4	0.6	1.0	0.1
Lung FEV1/FVC ratio	1.6	8.4	24.1	0.7	-2.9	-4.9	-0.7
Lung FVC	0.8	4.1	11.8	-1.5	1.5	3.4	-0.2
Neuroticism	1.0	2.3	4.9	-0.3	1.8	2.2	1.1
Chronotype (morning person)	0.5	1.1	2.8	-1.7	0.8	0.8	0.4
Hair Pigment	0.5	15.2	30.2	0.7	-5.5	-5.5	-0.3
Tanning	0.1	1.2	2.0	1.2	0.6	-1.4	-1.0
Hand grip strength (left)	0.2	0.4	0.8	0.3	-0.3	-0.9	0.8
Number of treatments/medications taken	1.3	2.4	7.3	-1.4	0.3	2.7	-0.2
Average weekly spirits intake	0.0	0.0	0.0	0.0	-0.1	0.2	-0.1
Sensitivity / hurt feelings	0.7	1.3	3.5	1.9	-0.9	0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.1	-0.8	-0.9	-0.2
Hearing difficulty/problems: Yes	1.1	1.8	3.9	2.0	1.0	-0.2	1.4
Relative age of first facial hair	0.7	1.3	3.6	-1.9	-0.6	1.1	0.4
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	6.0	-0.9	1.7	2.4	2.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.2	0.2	-0.2	0.0	1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.1	-0.9	-0.2	-0.7
Systolic blood pressure, automated reading	0.9	2.5	5.0	-2.2	1.5	1.4	0.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.9	-1.0	0.1	-1.7	1.1
Angina	0.7	1.0	2.1	-1.5	0.5	0.4	1.1
Medication for hormone replacement therapy	1.0	1.1	1.7	-1.0	1.3	1.0	0.8
Vitamin and mineral supplements	0.6	0.8	2.3	-0.8	1.5	0.4	-0.3
Supplements: Zinc	1.2	1.3	4.0	2.0	-0.5	-1.1	-0.1
Medication: Co-codamol	1.4	1.6	4.8	-2.2	0.9	0.9	0.1
Medication: Metformin	1.2	1.6	2.9	-0.8	1.6	0.7	1.7
Diabetes (father)	2.6	3.2	5.2	-0.2	2.0	1.9	2.3
Diabetes (mother)	0.5	0.7	2.4	-1.6	0.6	-0.0	0.0
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.3	-0.1	0.5
Pack years adult smoking proportion	0.2	0.3	0.9	0.1	-0.4	-1.0	-0.2
Impedance of leg (right)	0.5	2.4	5.5	-1.6	0.3	2.4	1.2
Leg fat-free mass (left)	0.4	1.9	5.6	0.4	-0.3	-2.4	-1.4
Trunk fat percentage	0.2	0.8	2.8	-0.1	-0.7	-1.7	-0.2
Hand grip strength (right)	0.3	0.8	1.8	-0.8	0.3	-0.7	1.3
Townsend deprivation index at recruitment	2.2	3.1	6.8	-0.8	-2.6	-1.8	-1.2
Current tobacco smoking	0.6	1.0	1.6	-0.4	1.0	-1.1	1.3
Average weekly fortified wine intake	0.5	0.6	1.4	-0.5	0.0	0.8	1.2
Maternal smoking around birth	0.5	0.7	1.2	-1.1	0.4	-1.0	0.8
Fed-up feelings	1.0	1.8	3.3	-1.0	-1.8	0.2	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.8	-0.5	0.9	-0.8	1.4
Relative age voice broke	0.8	1.2	4.1	-0.7	0.5	0.3	2.0
Taking other prescription medications	1.7	2.7	7.7	-0.9	1.4	2.8	0.5
Age when periods started (menarche)	0.9	2.2	4.9	1.0	2.2	1.3	1.1
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	6.8	-0.9	-2.5	-2.6	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	7.5	0.1	-2.7	-1.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0
Qualifications: CSEs or equivalent	2.6	3.5	5.0	-1.0	-2.2	-2.0	-1.9
Serious illness, injury or assault to yourself	1.4	1.8	4.4	-2.1	0.2	0.0	1.6
High blood pressure	1.6	4.4	8.4	-2.9	0.4	2.7	-1.1
Hayfever, allergic rhinitis or eczema	2.1	4.6	8.5	0.2	2.9	2.0	2.5
Multivitamins +/- minerals	2.2	2.8	5.6	1.2	-2.0	-2.4	-0.2
Stomach or abdominal pain in last month	1.0	1.2	3.2	-0.5	1.0	-0.5	1.8
Supplements: Glucosamine	0.3	0.4	0.7	0.8	-0.3	-0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.4	-2.1	-1.3	0.2	-1.1
Medication: Atenolol	1.1	1.4	3.6	0.4	-1.3	0.0	-1.9
Medication: Levothyroxine sodium	0.8	1.3	3.4	1.9	0.9	-1.0	0.4
Sitting height	0.3	2.0	5.3	-1.4	0.4	-0.7	-2.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.5	0.8	0.5	-1.1
High blood pressure (mother)	0.7	0.9	1.5	-1.2	-0.4	1.1	-0.9
Body mass index (BMI)	0.2	0.7	2.7	0.0	-0.2	-1.6	-0.1
Impedance of leg (left)	0.5	2.6	4.7	-1.4	0.6	2.2	1.9
Leg predicted mass (left)	0.4	2.1	6.0	0.6	-0.4	-2.5	-1.4
Trunk fat mass	0.3	1.1	4.0	-0.2	-0.6	-2.0	-0.3
Waist circumference	0.2	0.6	1.4	-0.7	1.2	0.0	0.7
Number of incorrect matches in round	0.9	1.4	2.7	1.7	0.7	1.5	-0.5
Past tobacco smoking	1.5	2.8	6.9	-2.6	-1.2	0.2	-1.7
Alcohol usually taken with meals	0.6	0.9	1.4	0.1	-1.1	-1.2	-1.1
Nervous feelings	1.6	3.0	6.0	0.2	1.8	2.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.6	-1.1	-0.3	0.6
Hearing difficulty/problems with background noise	2.5	4.1	11.9	1.1	1.1	1.4	3.5
Hair/balding pattern: Pattern 2	0.8	1.0	3.1	-1.8	0.1	0.7	0.6
Had menopause	0.3	0.4	0.7	-0.6	-0.7	0.8	-0.3
Had other major operations	0.2	0.3	0.5	-0.4	-0.7	-0.6	-0.3
Forced vital capacity (FVC)	0.5	1.9	2.9	-1.4	1.6	1.7	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	11.5	-0.1	-2.9	-3.4	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	1.0	0.4	0.6	0.5
Qualifications: None of the above	0.1	0.3	0.6	-0.3	-0.1	0.6	-0.8
Financial difficulties in last 2 years	1.6	2.2	3.4	-1.4	-1.8	-1.7	-0.6
Mouth/teeth dental problems	2.0	3.0	6.0	-2.1	-1.2	-2.4	-0.6
Heart attack	0.2	0.2	0.6	-0.3	-0.3	0.8	-0.4
Allergy	0.4	1.0	1.6	0.2	-1.1	-1.3	-1.0
Pain all over the body in last month	0.2	0.3	0.7	-0.2	-0.5	-0.8	-0.3
Diabetes (self-reported)	0.7	1.1	2.9	-1.7	0.2	0.1	1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.3	1.4	-0.1	1.8	0.2
Medication: Ramipril	1.2	1.5	3.1	-1.8	-0.9	1.1	-0.9
Medication: Simvastatin	4.4	6.4	16.8	-1.9	1.7	4.1	1.5
Fluid intelligence score	0.6	1.3	3.1	-1.8	0.7	1.2	-0.4
Illnesses of siblings	0.8	1.1	4.0	0.5	-0.3	-2.0	-0.3
Neuroticism score	0.7	1.4	2.9	0.2	1.2	1.7	1.1
Weight	0.2	1.1	4.2	0.3	0.2	-2.1	-0.3
Impedance of arm (right)	0.1	0.6	2.1	0.5	0.3	1.4	0.0
Arm fat percentage (right)	0.2	0.8	2.5	0.1	-0.7	-1.6	-0.3
Trunk fat-free mass	0.2	1.0	3.2	0.4	-0.0	-1.8	-0.8
Hip circumference	0.3	1.2	2.7	0.2	-0.2	-1.6	-1.4
Time employed in main current job	0.3	0.3	1.0	-0.3	-0.3	-1.0	-0.1
Alcohol intake versus 10 years previously	0.7	1.0	2.7	-0.5	-0.8	0.7	-1.6
Father’s age at death	0.5	0.6	1.8	0.8	-1.4	-0.4	-0.0
Worrier / anxious feelings	0.8	1.6	3.7	1.2	0.8	1.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	4.8	-2.2	-0.3	0.3	0.7
Falls in the last year	0.2	0.3	0.6	-0.8	-0.7	-0.4	0.2
Hair/balding pattern: Pattern 3	1.1	1.6	3.9	0.7	-0.8	-2.0	1.2
Number of live births	0.2	0.2	0.5	0.7	0.6	0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.0	-1.4	0.6	0.2	0.1
Pulse rate	0.8	1.4	2.9	-1.7	-0.5	0.4	-1.5
Happiness	1.3	1.5	3.6	1.2	-0.9	-0.2	-1.9
Noisy workplace	0.4	0.5	1.0	0.6	-0.3	1.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.7	-0.9	0.9	0.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	5.0	-2.2	1.1	0.6	-0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.1	0.0	1.1	-0.9
Asthma	0.4	0.9	2.2	-0.5	-0.6	1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	3.1	1.3	0.2	-1.8	0.8
Medication: Cholesterol lowering	1.4	2.2	2.8	-1.5	1.0	1.6	1.7
Depression (self-reported)	0.3	0.4	0.6	0.5	0.8	0.5	0.7
Medication: Lansoprazole	1.4	1.6	3.5	-1.0	-1.3	-1.9	-0.3
Prospective memory result	1.2	1.5	3.1	1.1	-1.7	-0.9	-0.9
Lung cancer (father)	0.5	0.6	1.7	0.6	-0.2	-1.3	-0.3
Illnesses of mother	1.2	1.5	5.7	2.4	0.2	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-1.0	1.0	-0.8	0.5
Pulse wave Arterial Stiffness index	2.8	3.3	7.5	-0.3	1.9	2.7	1.4
Impedance of arm (left)	0.0	0.2	0.4	0.1	-0.1	0.7	0.5
Arm fat mass (right)	0.2	1.0	3.0	-0.1	-0.5	-1.7	-0.8
Trunk predicted mass	0.2	1.0	3.3	0.3	-0.1	-1.8	-0.9
Standing height	0.1	0.6	1.0	0.7	1.0	-0.9	-0.2
Length of working week for main job	1.1	1.2	2.2	-0.1	1.2	-1.5	1.1
Exposure to tobacco smoke at home	0.4	0.4	0.8	0.9	0.7	0.2	0.6
Breastfed as a baby	0.4	0.5	0.8	-0.5	0.9	0.9	0.4
Tense / ‘highly strung’	0.4	0.7	1.0	1.0	0.9	0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	8.2	2.9	1.9	2.0	2.1
Hair/balding pattern: Pattern 4	1.7	4.2	7.1	1.8	-1.4	-2.1	-2.7
Birth weight of first child	0.6	1.1	3.0	0.1	1.7	-0.3	1.1
Peak expiratory flow (PEF)	0.9	2.1	6.9	-0.4	-0.9	-2.6	0.6
Pulse wave reflection index	0.5	0.6	1.7	0.1	0.8	0.4	1.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.9	0.0	-0.2	0.0
Loud music exposure frequency	1.3	1.5	4.7	0.4	0.6	-0.8	2.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-1.0	-0.7	0.8	0.3
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	8.8	3.0	0.8	2.0	2.1
Blood clot in the leg (DVT)	0.5	0.6	1.0	1.0	-0.6	-0.4	-0.9
Medication: Paracetamol	0.3	0.5	1.6	0.3	-0.2	1.3	-0.2
Headache pain in last month	0.4	0.6	1.6	-1.3	-0.7	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	7.5	2.7	-1.6	-2.0	-1.2
Glaucoma (self-reported)	0.7	0.8	2.0	0.7	-0.7	0.1	-1.4
Gout (self-reported)	0.6	0.9	1.9	1.2	0.2	-0.2	1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.7	2.3	1.4	1.5	-1.3	0.8
Medication: Amlodipine	0.5	0.7	1.4	-1.1	-0.2	1.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.1	-0.1	-1.2	0.4	-1.8
Birth weight	0.8	1.8	4.7	1.3	-0.9	-2.2	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.1	-0.6	-0.6	-0.7
High blood pressure (siblings)	1.1	1.7	3.3	-1.6	-0.4	1.8	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	-1.0	1.6	0.6	0.4
Body fat percentage	0.2	0.9	2.8	-0.3	-0.8	-1.7	-0.0
Leg fat percentage (right)	0.2	0.8	1.6	-1.0	-0.8	-1.3	-0.1
Arm fat-free mass (right)	0.2	1.3	4.8	-0.2	-0.3	-2.2	-0.5
Exposure to tobacco smoke outside home	0.7	1.0	2.5	-0.7	-0.9	-0.2	-1.6
Comparative body size at age 10	0.3	0.8	1.3	0.9	-1.0	-0.4	-1.2
Number of full brothers	3.5	4.4	9.4	3.1	-2.3	-0.2	-1.7
Worry too long after embarrassment	0.9	1.6	2.5	0.1	1.5	1.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.9	-0.2	1.4	2.2	1.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	-0.3	0.0	0.1	1.2
Number of children fathered	0.4	0.4	0.5	0.5	-0.7	-0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	1.7	-0.5	1.1	-1.3
Age at first live birth	1.0	1.7	4.3	0.2	-1.5	-2.1	-0.6
Pulse wave peak to peak time	2.8	3.3	7.7	0.4	-1.8	-2.8	-1.5
Health satisfaction	0.1	0.1	0.4	-0.2	-0.6	0.3	-0.1
Shortness of breath walking on level ground	1.4	1.7	4.9	-2.2	-1.1	-0.4	-0.7
Qualifications: College or University degree	0.5	1.7	3.7	-0.3	1.7	0.2	1.9
Eye problems/disorders: None of the above	1.5	1.7	4.0	0.6	-1.5	-0.2	-2.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	0.6	-0.8	-0.6	-1.2
Emphysema/chronic bronchitis	0.5	0.6	1.6	-1.2	-0.8	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.4	0.7	0.1	0.4
Neck or shoulder pain in last month	1.3	1.8	3.2	-0.9	-0.3	1.8	1.8
Medication: Blood pressure	1.8	3.2	6.2	-1.8	1.8	2.5	0.3
Angina (self-reported)	0.7	0.9	1.3	-1.1	0.5	0.9	1.0
Migraine (self-reported)	1.0	1.3	3.4	-1.8	-1.2	0.1	-0.7
Medication: Ibuprofen	1.0	1.2	2.1	1.4	0.8	-0.8	1.2
Medication: Allopurinol	0.3	0.4	0.8	0.5	-0.9	-0.6	0.2
Medication: Omeprazole	0.7	0.8	2.4	-0.7	-0.4	1.6	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-0.0	0.5	0.9	-1.0
Mean time to correctly identify matches	0.4	0.7	1.8	1.4	-1.0	0.1	-0.1
Heart disease (mother)	1.5	1.9	2.3	-1.2	1.5	1.5	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.2	-0.2	0.7	-0.8	1.5
Whole body fat mass	0.3	1.2	4.0	-0.4	-0.8	-2.0	-0.5
Leg fat mass (right)	0.2	0.8	2.4	-0.8	-0.4	-1.6	-0.2
Arm predicted mass (right)	0.2	1.0	4.0	-0.1	-0.2	-2.0	-0.4
Pulse rate, automated reading	1.5	4.8	10.8	-3.3	-1.4	0.4	-2.5
Alcohol intake frequency.	1.4	3.2	5.4	-2.3	-2.1	-1.1	-1.3
Comparative height size at age 10	0.2	1.2	3.2	0.6	-1.2	-1.8	-0.1
Number of full sisters	0.1	0.1	0.2	-0.3	0.2	-0.1	-0.4
Suffer from ‘nerves’	1.7	2.6	5.9	0.5	1.6	1.3	2.4
Overall health rating	0.9	2.0	3.8	-1.9	1.2	1.5	0.7
Chest pain or discomfort	1.3	1.9	6.0	-2.5	0.7	1.1	-0.1
Had major operations	2.6	3.0	7.7	-0.7	1.7	1.0	2.8
Age at last live birth	0.7	1.0	2.3	0.1	-1.3	-1.5	0.1
Family relationship satisfaction	0.8	0.9	2.1	1.4	-1.0	-0.8	-0.3
Leg pain on walking	0.5	0.6	1.7	0.6	0.6	1.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.0	0.7	-2.0	0.0	-1.6
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.6	0.7	-0.3	-1.9	0.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.4	0.7	-0.3	1.0	-2.1
Medication: Aspirin	0.5	0.7	2.2	-1.5	-0.4	0.2	0.6
Supplements: Vitamin C	0.4	0.4	1.0	0.5	0.5	1.0	0.5
Knee pain experienced in last month	0.5	0.7	2.1	0.2	0.8	1.4	0.2
Hypertension (Self-reported)	1.6	4.5	8.8	-3.0	-0.0	2.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.8	-0.2	-1.1	-0.7	-1.7
Illnesses of father: Heart disease	3.1	4.3	10.4	-1.0	2.1	1.3	3.2
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.1	0.1	-0.0	0.6
Smoking status: Previous	1.4	2.1	3.9	2.0	1.0	1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.5	-0.3	-1.0	-0.9
Whole body fat-free mass	0.2	1.3	4.3	0.4	-0.1	-2.1	-0.9
Leg fat-free mass (right)	0.4	1.9	5.8	0.7	-0.1	-2.4	-1.2
Arm fat percentage (left)	0.3	1.1	3.5	-0.2	-0.9	-1.9	-0.3
Average weekly red wine intake	1.6	2.3	4.0	2.0	-1.2	-2.0	-0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.3	0.6	-0.3	2.3	-1.2
Mood swings	0.1	0.3	0.6	-0.8	-0.6	-0.1	-0.4
Loneliness, isolation	2.2	3.0	6.2	-0.7	-2.1	-2.5	-0.9
Long-standing illness, disability or infirmity	1.2	1.9	4.4	-1.7	0.2	2.1	0.2
Ever had bowel cancer screening	1.2	1.4	3.0	-1.0	0.5	1.7	1.0
Diabetes diagnosed by doctor	0.6	1.1	3.5	-1.9	-0.1	0.2	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.4	1.9	-0.7	-0.8	0.0
Friendships satisfaction	2.1	2.6	4.9	1.0	-2.1	0.3	-2.2
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.1	-1.0	0.2	0.4
Commuting to job workplace: Walk	0.7	0.8	1.9	-1.4	-1.0	-0.1	0.4
Eye problems/disorders: Cataract	2.7	3.1	4.1	-2.0	1.3	-1.6	2.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.9	2.0	0.3	0.3	0.2
Medication for cholesterol	2.0	3.1	4.9	2.2	1.2	-1.1	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	0.8	0.1	0.4	-1.3
Back pain experienced in last month	0.2	0.2	0.3	-0.4	-0.4	0.6	-0.5
Mineral and other dietary supplements	0.2	0.2	0.8	0.2	0.9	0.0	0.3
Breast cancer (self-reported)	0.7	0.8	1.5	-1.2	-0.5	-1.2	0.4
Asthma (self-reported)	0.4	0.7	1.7	-0.3	-0.7	1.3	-0.7
Osteoporosis (self-reported)	2.3	2.9	7.2	-1.9	0.8	2.7	0.4
Osteoarthritis (self-reported)	0.9	1.1	2.2	-1.3	0.6	-0.5	1.5
Medication: Aspirin	0.8	1.0	3.0	-1.7	-0.2	-0.4	1.0
Medication: Gliclazide	0.6	0.6	1.2	0.5	-1.0	-0.5	-1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	3.5	0.1	-0.6	-0.5	-1.9
Smoking status: Current	0.8	1.2	3.2	0.2	0.9	-1.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	-1.3	0.7	-0.0	0.6
Whole body water mass	0.3	1.6	5.0	0.5	-0.3	-2.2	-1.1
Leg predicted mass (right)	0.4	1.9	5.9	0.7	-0.1	-2.4	-1.2
Arm fat mass (left)	0.3	1.1	3.8	-0.2	-0.5	-1.9	-0.5
Number of self-reported non-cancer illnesses	1.1	1.9	5.3	-1.4	0.4	2.3	0.2
Average weekly champagne plus white wine intake	0.6	0.9	2.1	-1.4	0.1	-0.4	1.2
Miserableness	1.0	1.7	2.9	-1.1	1.6	1.7	0.7
Guilty feelings	2.2	3.3	9.1	1.5	1.3	3.0	0.2
Wears glasses or contact lenses	0.3	0.3	0.6	-0.2	-0.2	0.7	0.8
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.0	0.4	-0.8	-0.1
Hearing aid user	0.8	0.9	1.2	-0.9	1.1	0.7	0.9
Mother’s age at death	1.3	1.7	2.7	0.4	1.6	1.2	1.5
Financial situation satisfaction	0.1	0.1	0.2	0.4	-0.4	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.4	0.5	0.7	2.1	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.6	0.6	0.7	0.3	1.3
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.3	-0.0	1.2	-1.1
Medication: Blood pressure	2.2	4.1	9.1	-1.1	-2.3	1.1	-3.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.7	0.8	-0.2	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.6	0.4	0.1	0.3
High cholesterol (Self-reported)	2.6	4.6	11.5	-2.3	1.0	3.4	0.6
Medication: Bendroflumethiazide	0.9	1.4	2.4	-1.6	0.2	1.3	-1.2
Medication: Paracetamol	0.4	0.6	1.7	0.4	-0.2	1.3	-0.5
Medication: Lisinopril	0.9	1.2	3.1	-1.0	0.5	1.8	-0.6
Medication: Atorvastatin	1.4	1.7	6.5	-2.5	0.2	0.6	0.1
Illnesses of father: High blood pressure	0.3	0.3	1.0	1.0	-0.3	-0.4	-0.4
Alcohol drinker status: Never	0.9	1.1	2.6	-0.6	-1.2	-1.6	-0.4
Ever smoked	1.4	2.5	4.4	2.1	1.1	-0.8	2.0
Basal metabolic rate	0.3	1.4	4.7	0.4	-0.2	-2.2	-0.9
Leg fat percentage (left)	0.2	0.8	2.2	-0.7	-0.7	-1.5	0.1
Arm fat-free mass (left)	0.2	1.2	4.1	0.3	-0.3	-2.0	-0.9
Number of operations (self-reported)	0.0	0.0	0.1	0.2	-0.0	0.3	0.2
Average weekly beer plus cider intake	0.8	1.2	2.7	-0.3	1.4	-0.2	1.6
Irritability	0.4	0.6	1.5	-0.6	0.6	0.5	1.2
Risk taking	1.7	2.5	8.1	1.0	-0.8	-2.8	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	0.3	0.2	-0.9	0.9
Fractured/broken bones in last 5 years	1.0	1.3	3.0	0.6	-1.2	0.8	-1.7
Age started oral contraceptive pill	1.0	1.3	2.2	-1.0	-1.4	0.0	-1.5
Diastolic blood pressure, automated reading	0.2	0.5	1.3	-0.6	0.4	1.2	-0.6
Ever depressed for a whole week	0.3	0.3	0.6	0.7	-0.5	0.3	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.9	-1.0	-0.7	-0.2	0.4
Commuting to job workplace: Cycle	0.9	1.1	2.2	0.6	1.5	1.2	0.6
Myopia	0.7	0.9	1.9	0.9	-1.1	-0.1	-1.4
Vascular/heart problems diagnosed by doctor	1.6	4.3	9.2	3.0	0.0	-2.6	1.2
Cholesterol lowering medication	3.6	5.2	10.7	-3.3	0.9	3.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	-1.0	-0.7	0.6	0.0
Pain experienced in last month	0.1	0.2	0.6	-0.4	0.2	-0.1	-0.8
Supplements: Calcium	0.3	0.4	0.8	-0.2	-0.9	0.8	-0.3
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.8	-0.3	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.0	-0.4	0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	1.0	-0.7	-0.3	-1.1
Heart disease (siblings)	0.5	0.6	1.0	0.7	1.0	0.3	0.9
Alcohol drinker status: Previous	0.3	0.3	1.1	0.2	-1.1	-0.0	-0.3
Pack years of smoking	0.4	0.6	1.1	0.4	-0.8	-1.1	-0.5
Impedance of whole body	0.2	1.2	2.2	-1.0	0.3	1.5	1.2
Leg fat mass (left)	0.2	0.7	2.4	-0.7	-0.3	-1.5	-0.1
Arm predicted mass (left)	0.2	1.0	3.1	0.5	-0.1	-1.8	-0.8