Hub : Genes

ANXA3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0240 1.7e-03 0.034 0.032 0.035 0.030 0.029 5.0e-05 8.2e-05 3.9e-05 1.4e-04 1.7e-04
2 GTEx Brain Cerebellum 0.2290 0.0920 7.6e-03 0.002 NA 0.008 NA -0.009 2.8e-01 NA 1.9e-01 NA 8.1e-01
3 GTEx Breast Mammary Tissue 0.1190 0.0490 5.4e-03 0.050 NA 0.023 NA 0.051 1.4e-03 NA 2.2e-02 NA 1.3e-03
4 GTEx Breast Mammary Tissue (Male) 0.0528 0.0641 2.5e-01 -0.012 NA -0.009 NA -0.011 8.2e-01 NA 5.7e-01 NA 6.8e-01
5 GTEx Breast Mammary Tissue (Female) 0.1558 0.0729 1.7e-02 0.001 NA -0.003 NA 0.059 3.0e-01 NA 3.9e-01 NA 7.5e-03
6 GTEx Esophagus Muscularis 0.2950 0.0610 8.7e-11 0.227 NA 0.288 NA 0.286 6.5e-14 NA 8.4e-18 NA 1.2e-17
7 GTEx Nerve Tibial 0.3960 0.0713 1.3e-15 0.161 NA 0.302 NA 0.253 1.7e-11 NA 8.9e-22 NA 6.1e-18
8 GTEx Pituitary 0.2890 0.0910 1.0e-04 0.186 NA 0.131 NA 0.176 2.0e-05 NA 3.6e-04 NA 3.5e-05
9 GTEx Skin Not Sun Exposed Suprapubic 0.1230 0.0600 4.8e-03 0.068 NA 0.027 NA 0.057 1.4e-04 NA 1.2e-02 NA 4.6e-04
10 GTEx Thyroid 0.0910 0.0370 3.1e-03 0.028 NA 0.038 NA 0.015 3.0e-03 NA 6.0e-04 NA 2.3e-02
11 METSIM Adipose 0.1240 0.0367 2.3e-08 0.098 0.050 0.091 0.087 0.092 1.7e-14 5.9e-08 1.8e-13 5.2e-13 1.3e-13
12 NTR Blood 0.0184 0.0082 2.8e-04 0.006 0.006 0.009 0.005 0.009 4.0e-03 4.0e-03 6.6e-04 5.6e-03 5.7e-04
13 ROSMAP Brain Pre-frontal Cortex 0.0461 0.0201 8.1e-04 0.074 0.017 0.051 0.051 0.067 8.1e-10 2.2e-03 3.9e-07 3.2e-07 5.3e-09
14 YFS Blood 0.0898 0.0230 4.4e-13 0.045 0.052 0.060 0.060 0.056 1.1e-14 1.9e-16 8.7e-19 6.5e-19 6.9e-18
15 TCGA Breast Invasive Carcinoma 0.0364 0.0192 1.2e-03 0.020 0.009 0.007 NA 0.010 3.6e-05 4.3e-03 1.2e-02 NA 2.7e-03
16 TCGA Head and Neck Squamous Cell Carcinoma 0.0243 0.0149 5.1e-03 0.018 0.020 0.009 NA 0.017 3.7e-03 2.4e-03 3.2e-02 NA 4.7e-03
17 TCGA Brain Lower Grade Glioma 0.1446 0.0631 8.6e-09 0.086 0.090 0.092 NA 0.090 5.1e-10 2.2e-10 1.5e-10 NA 2.2e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.3 0.4 2.7 -0.3 0.0 0.0 -1.6 0.0 -0.3 1.3 0.2 -0.7 0.7 0.3 -0.4 0.4 0.6 -0.7 -0.3 0.3
Bipolar Disorder or Schizophrenia 0.4 1.0 4.6 0.1 0.0 0.2 -2.1 1.4 -1.0 1.7 -0.0 -0.8 1.6 0.1 0.1 0.2 1.4 -1.0 -0.3 0.1
Depressed Affect (Nagel 2018) 0.9 1.9 5.8 0.3 0.0 -1.4 -1.4 0.1 -1.5 1.6 1.2 -2.4 0.5 -1.8 1.0 1.5 1.1 -1.8 -2.0 1.5
Depression (Nagel 2018) 0.4 0.6 1.5 -0.3 0.0 -1.0 0.8 -0.9 0.7 -0.4 0.7 -0.9 -0.4 -1.1 -1.0 1.2 -0.8 -0.0 -0.6 0.8
Intelligence (Savage-Jansen 2018) 0.7 2.3 5.1 -1.9 0.0 1.6 0.2 1.8 1.2 -0.8 -2.3 0.4 -1.2 1.3 -1.4 -2.1 -1.1 1.4 2.1 -2.1
Neuroticism (Nagel 2018) 0.7 1.7 5.0 0.5 0.0 -1.4 -1.4 -0.1 -0.8 0.8 1.9 -2.2 0.2 -1.7 -0.6 2.2 -0.4 -0.9 -1.9 1.6
Schizophrenia (2018) 0.3 0.7 2.9 0.4 0.0 0.3 -1.4 1.7 -1.1 1.1 -0.2 -0.5 1.5 -0.1 0.4 -0.0 1.3 -0.7 -0.1 -0.1
Schizophrenia vs Biploar Disorder 0.5 0.6 3.0 0.1 0.0 0.1 -0.6 0.6 -1.3 0.1 -0.6 0.5 1.7 -0.0 1.7 -0.9 0.8 -0.5 0.2 -0.3
Worry (Nagel 2018) 0.2 0.3 1.1 0.5 0.0 -0.3 -0.3 0.9 0.0 0.0 0.9 -0.6 0.1 -0.7 -0.8 1.1 -0.5 -0.1 -0.5 0.7
Alzheimer’s Disease (in mother) 0.4 0.4 1.4 0.5 0.0 -1.2 -1.0 -1.1 -0.3 0.1 0.5 -0.3 0.3 -0.9 -0.0 0.3 -0.5 0.1 -1.1 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.2 -1.1 0.0 -0.4 0.2 0.5 -0.7 0.5 -0.8 -0.8 0.4 -1.1 0.2 -0.7 0.9 -0.6 -0.4 -0.7
Alzheimer’s Disease (including proxy) 0.3 0.4 2.2 0.3 0.0 -1.0 -1.5 -0.6 -0.6 0.6 0.4 -0.3 0.8 -0.8 -0.2 0.2 0.1 0.0 -0.9 -0.3
Crohns Disease (2017) 0.2 0.5 2.4 -0.9 0.0 0.1 -0.4 -0.6 -0.0 0.7 -0.5 -1.2 -1.6 0.3 0.3 -0.4 -0.5 0.2 -1.1 -0.9
Irritable Bowel Disease (IBD) 0.4 1.0 2.4 -0.3 0.0 -0.4 -0.6 -1.5 -1.4 1.4 -0.6 -1.5 -0.6 0.1 1.4 -0.6 1.2 -0.8 -1.3 -0.2
Ulcerative Colitis (UC) 0.5 0.9 3.1 -0.3 0.0 -0.1 -0.7 -1.1 -1.5 1.4 -0.8 -0.8 0.5 0.6 1.2 -1.1 1.8 -0.9 -0.5 -0.3
Major Depression (MDD) 0.1 0.1 0.5 -0.2 0.0 0.2 -0.1 0.7 0.3 0.1 -0.6 -0.1 0.4 0.1 0.1 -0.3 0.3 -0.0 0.2 -0.3
Reaction Time 0.4 0.7 2.6 0.1 0.0 0.6 -0.6 1.1 0.5 0.6 -1.6 0.8 -0.1 0.5 -1.2 -1.0 0.4 0.6 1.5 -1.3
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.2 -1.1 0.0 1.4 -0.1 1.4 0.9 -0.6 -1.2 0.4 -1.5 1.2 -1.3 -1.1 -1.2 1.2 1.3 -1.3
Breast Cancer 0.1 0.3 1.3 0.0 0.0 0.9 -0.1 1.0 -0.3 0.6 0.0 0.0 -0.2 0.7 1.1 0.1 0.8 -0.2 -0.2 0.1
Ovarian Cancer 0.2 0.3 1.1 -0.7 0.0 0.1 -0.4 -0.6 0.4 0.3 0.4 0.4 0.2 0.4 -1.1 0.2 -1.0 0.5 -0.2 -0.1
Prostate Cancer 0.5 0.7 2.5 -0.8 0.0 1.2 0.5 1.3 0.2 -0.3 -0.9 1.2 -0.2 1.1 0.2 -0.9 1.1 0.3 1.6 -0.4
Age at First Birth 0.5 0.7 3.3 0.3 0.0 -1.3 0.3 -1.8 -0.6 0.2 0.1 -1.3 0.3 -0.9 0.9 0.1 0.2 -1.0 -1.2 0.4
Bipolar Disorder (2011) 1.0 1.0 3.8 1.1 0.0 0.4 -1.3 1.3 -0.5 1.0 1.6 -0.7 0.8 0.1 0.0 2.0 0.1 -0.3 -0.9 1.5
Body Mass Index (BMI) (2010) 0.6 0.8 2.6 0.5 0.0 -0.3 -0.5 -0.7 1.0 -0.5 1.3 0.3 -0.9 0.1 -1.5 1.5 -1.6 1.0 -0.3 0.4
Coronary Artery Disease (CAD) 0.7 0.8 3.4 -0.6 0.0 1.3 1.3 1.8 1.1 -0.6 0.1 0.3 -1.4 0.6 -0.4 -0.0 -0.8 0.9 0.4 -0.6
Crohns Disease (2012) 0.1 0.2 1.4 -0.3 0.0 0.1 0.1 -0.4 -0.2 -0.4 0.0 -0.2 -1.2 0.2 0.6 0.4 -0.1 -0.0 -0.6 0.4
Mean Putamen Volume 2.4 2.8 10.0 -1.7 0.0 1.7 1.7 1.0 2.0 -1.2 -1.1 1.7 -1.9 1.6 -3.2 -0.7 -1.6 2.0 1.8 -1.3
Fasting Glucose 0.8 0.9 2.7 -0.8 0.0 0.8 0.8 0.5 0.9 -1.6 -1.0 1.5 -0.4 0.0 -0.6 -0.8 -0.4 1.4 1.6 -0.8
HbA1C 0.2 0.3 1.2 0.1 0.0 0.0 -0.6 -1.1 -0.4 0.3 -0.0 -0.0 0.0 -0.8 0.4 0.3 0.9 -0.3 0.1 1.0
HDL Cholesterol 0.3 0.6 1.8 -0.1 0.0 -1.2 0.0 -1.4 -0.7 0.6 0.4 -1.0 0.7 -0.7 0.8 0.5 0.5 -1.0 -0.8 0.9
LDL Cholesterol 4.4 7.0 16.0 -1.0 0.0 2.1 3.0 1.1 3.5 -3.3 -2.5 4.0 -2.1 1.7 -2.9 -2.3 -2.1 3.2 3.6 -3.0
Lupus 0.1 0.1 0.5 0.0 0.0 -0.5 0.3 -0.1 0.1 0.0 -0.4 -0.4 -0.5 -0.3 0.7 -0.5 0.1 -0.4 0.2 -0.2
Neuroticism (2016) 1.4 2.0 3.8 -1.3 0.0 1.9 0.7 1.5 1.6 -1.1 -1.0 1.3 -1.6 1.7 -1.8 -0.4 -1.3 1.9 1.8 -1.3
Primary Biliary Cirrhosis 0.2 0.3 1.3 -1.1 0.0 -0.2 0.1 -0.1 0.3 0.1 -0.9 0.1 0.0 -0.1 -0.8 -0.9 0.3 0.3 0.8 -0.9
Rheumatoid Arthritis 0.5 0.7 5.2 -0.8 0.0 -1.4 -0.8 -2.3 0.1 -0.0 0.3 0.1 -0.0 -0.9 0.8 -0.0 -0.2 -0.1 -1.1 -0.4
Schizophrenia (2014) 0.4 1.0 4.5 0.3 0.0 0.2 -1.7 2.1 -1.1 1.3 0.2 -0.3 2.0 -0.4 0.1 -0.1 1.1 -0.9 -0.3 -0.1
Triglycerides 0.9 1.5 3.2 -0.4 0.0 0.8 0.6 0.6 1.2 -1.7 -1.4 1.8 -0.9 0.8 -1.1 -1.7 -0.8 1.6 1.8 -1.8
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.3 -1.1 0.0 0.8 0.9 -0.1 0.4 -0.4 -1.0 0.6 -0.8 1.1 -0.5 -0.8 -0.4 0.6 1.0 -0.5
Ulcerative Colitis 0.8 1.2 5.4 0.1 0.0 -0.1 -1.1 0.6 -2.0 1.5 -0.9 -0.5 1.0 -0.1 1.3 -0.9 2.3 -1.6 0.1 0.1
Blood Eosinophil Count 0.5 4.2 10.8 -1.5 0.0 2.9 2.5 0.9 2.0 -1.8 -1.7 2.2 -3.3 3.0 -1.8 -1.7 -0.9 2.0 2.4 -1.7
Blood Platelet Count 0.2 2.5 6.1 2.4 0.0 -1.3 -2.4 -1.6 -1.8 1.7 1.2 0.3 2.3 -0.4 0.5 1.2 2.5 -1.7 -0.7 1.7
Blood Red Count 1.0 10.0 29.1 -2.2 0.0 4.5 2.6 4.0 2.0 -2.4 -3.9 4.4 0.6 3.6 -2.5 -3.5 -0.8 2.9 5.4 -2.6
Blood White Count 0.8 5.6 13.8 -2.5 0.0 2.5 1.3 1.9 2.7 -0.7 -3.2 2.2 -1.8 2.4 -2.7 -3.1 -0.2 2.3 3.7 -3.0
Heel T-Score 0.6 4.7 14.4 -3.5 0.0 1.2 0.8 0.7 1.7 0.1 -3.8 -0.4 -2.6 1.1 -2.7 -3.4 -0.7 1.7 1.9 -3.7
BMI 0.8 4.9 18.9 4.3 0.0 -1.9 -0.6 -0.8 -2.2 1.4 2.7 -1.2 2.5 -2.1 0.5 3.3 1.5 -2.0 -2.3 3.4
Height 0.0 0.9 2.6 0.2 0.0 1.4 1.6 1.4 0.9 -1.6 -0.1 1.4 0.3 0.6 0.2 -0.6 -0.8 0.9 0.2 -1.0
Waist Hip Ratio (WHR) 0.2 0.8 5.2 2.3 0.0 0.2 -1.0 1.6 -0.3 -0.7 0.6 1.0 0.6 -0.3 0.8 0.6 0.6 -0.4 0.1 0.7
Systolic Blood Pressure 0.4 2.1 9.1 -2.0 0.0 0.5 1.8 -0.8 0.2 -0.8 -3.0 0.4 -0.6 0.7 0.7 -2.7 0.4 1.2 1.6 -2.1
Smoking Status 0.4 1.1 4.3 0.6 0.0 -0.7 -1.2 -0.3 0.3 0.3 2.1 -1.3 0.3 -0.6 -0.5 1.7 -1.4 -0.1 -1.8 0.9
Allergy or Eczema 0.3 0.7 5.2 -1.2 0.0 -0.5 0.2 -1.3 0.7 -0.7 -0.3 -0.0 -0.8 -0.0 -2.3 -0.4 -1.1 0.4 0.3 -0.4
Cardiovascular Disease 0.2 0.5 1.6 -0.1 0.0 -0.6 -0.3 0.2 -1.1 1.3 -0.9 -1.1 0.7 -0.7 0.2 -0.4 1.1 -0.9 0.0 0.0
Hypothyroidism (self reported) 0.2 0.4 1.0 0.8 0.0 -0.6 -0.0 0.3 -0.7 0.7 0.8 -0.7 0.3 -1.0 -0.8 0.9 0.2 -0.7 -0.8 0.8
Respiratory disease 0.2 0.5 1.7 -0.6 0.0 -0.0 -1.1 -0.4 0.1 1.3 -1.0 -0.5 1.0 0.4 -1.1 -0.7 0.5 -0.5 -0.0 -0.8
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.7 0.2 0.0 -1.4 -0.2 -1.1 -0.8 0.5 -0.4 -0.8 -0.3 -1.4 1.3 -0.4 1.6 -0.8 -0.4 -0.0
Lung FEV1/FVC ratio 0.7 3.8 21.3 -0.6 0.0 0.6 4.6 -2.1 3.0 -2.0 0.5 0.3 -3.3 1.0 -1.0 0.8 -2.2 1.4 1.6 1.2
Lung FVC 0.1 0.7 2.5 0.1 0.0 0.7 0.7 1.6 1.0 -1.1 1.1 0.7 0.1 -0.4 1.2 0.8 -1.2 -0.3 -0.9 0.4
Neuroticism 0.3 0.8 3.1 0.3 0.0 -0.4 0.4 0.7 0.4 -0.5 1.5 -1.1 -1.2 -1.3 -0.6 1.8 -0.7 0.1 -1.0 1.1
Chronotype (morning person) 0.3 0.8 2.3 -0.5 0.0 1.3 1.3 -0.2 0.8 -1.0 -0.7 0.7 -1.5 1.3 0.2 -0.6 -0.2 0.9 0.6 -0.8
Hair Pigment 1.0 28.8 97.0 0.4 0.0 -4.3 -8.9 -2.6 -5.4 8.6 4.1 -9.8 -0.2 -3.0 2.4 4.1 1.0 -6.5 -9.3 2.5
Tanning 0.0 0.1 0.9 0.3 0.0 -0.4 0.6 -0.9 0.1 -0.2 0.3 -0.4 0.4 -0.3 0.2 0.1 0.3 -0.2 -0.3 0.3
Hand grip strength (left) 0.2 0.4 2.1 -0.9 0.0 0.1 -0.7 -0.4 -0.1 -0.1 -1.3 0.3 -0.2 0.6 -0.3 -1.5 0.1 0.3 0.7 -1.0
Number of treatments/medications taken 0.4 0.8 2.8 -0.8 0.0 1.6 0.4 1.7 0.5 0.4 -0.9 0.7 0.4 1.1 -1.1 -0.5 0.5 0.1 1.0 -0.9
Average weekly spirits intake 0.8 1.0 2.9 1.6 0.0 -0.3 0.8 -1.1 0.9 -1.6 0.7 1.7 -0.6 0.1 -1.5 0.5 -0.7 1.1 0.7 0.5
Sensitivity / hurt feelings 0.9 1.5 6.0 1.8 0.0 -0.8 -1.1 -0.2 -0.2 0.2 2.4 -1.0 0.1 -1.0 -1.0 2.3 -0.8 -0.5 -1.7 1.6
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.6 -0.4 0.0 0.6 1.3 0.2 1.6 -1.2 0.4 0.5 -0.5 0.1 -1.6 0.8 -1.5 1.2 0.5 0.1
Hearing difficulty/problems: Yes 1.1 1.7 5.2 0.8 0.0 0.1 -1.5 0.8 -2.1 2.0 0.1 -1.5 1.6 -0.1 1.4 0.2 2.3 -1.8 -1.0 0.8
Relative age of first facial hair 1.1 2.3 7.0 -1.3 0.0 1.5 0.8 1.1 -0.1 -1.0 -2.0 2.4 1.1 1.1 1.7 -2.2 2.0 0.6 2.7 -0.8
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.9 0.7 0.0 -0.1 -0.5 1.0 -0.5 0.4 0.1 -0.6 -0.2 -0.4 0.3 0.0 0.5 -0.4 -0.6 -0.0
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.8 1.0 0.0 -0.9 1.2 -0.6 0.7 -1.2 1.3 -0.1 -0.4 -1.3 0.5 1.3 -0.4 0.7 -0.8 1.2
Ever had hysterectomy (womb removed) 0.6 0.7 2.3 -0.5 0.0 1.0 1.0 0.9 -0.0 -0.3 -0.9 1.0 1.5 0.6 0.8 -0.8 1.0 0.4 1.0 -0.5
Systolic blood pressure, automated reading 0.2 0.7 2.3 -1.0 0.0 0.2 1.5 -0.9 0.1 -0.6 -1.2 0.9 1.0 0.4 1.2 -1.1 0.6 0.3 0.8 -0.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.3 0.1 0.0 -1.0 -0.4 -0.8 -0.5 -0.2 0.1 0.3 0.4 -0.8 0.8 0.1 1.1 -0.4 0.3 0.9
Angina 1.5 2.0 4.6 -2.1 0.0 1.9 0.9 1.5 1.3 -1.0 -1.5 1.2 -0.7 1.5 -1.3 -1.4 -1.2 1.8 1.7 -1.3
Medication for hormone replacement therapy 0.5 0.6 2.0 -0.1 0.0 0.1 0.6 -1.0 0.7 -1.2 0.5 0.6 -1.4 0.2 -1.4 0.7 -0.9 1.0 0.3 0.3
Vitamin and mineral supplements 1.0 1.3 3.1 -1.7 0.0 -0.5 -1.1 -0.7 -0.6 1.5 -1.7 -1.6 -1.2 0.2 1.5 -1.4 1.4 -0.8 -0.1 -0.9
Supplements: Zinc 0.4 0.5 3.4 0.4 0.0 0.6 0.2 1.8 0.1 -0.8 0.4 0.1 0.5 0.0 -1.0 0.4 -1.2 0.8 0.0 -0.3
Medication: Co-codamol 0.7 0.8 2.0 -0.5 0.0 0.4 1.4 -0.7 1.3 -1.2 -0.4 0.9 -1.0 0.5 -0.9 -0.5 -0.9 1.4 0.8 -0.8
Medication: Metformin 0.8 1.1 4.6 -0.1 0.0 -2.1 0.0 -1.7 -0.8 0.9 -0.1 -1.0 -0.5 -2.1 0.8 0.1 1.2 -1.5 -0.5 0.3
Diabetes (father) 1.1 1.4 4.7 1.1 0.0 -1.7 -0.9 -0.1 -1.1 0.2 1.0 -1.4 0.4 -2.2 1.5 0.8 0.4 -1.4 -1.9 0.7
Diabetes (mother) 0.6 0.8 3.9 2.0 0.0 0.8 -0.4 1.0 -1.5 0.3 0.1 0.4 1.4 0.8 0.5 0.3 0.9 -0.6 0.4 0.8
Severe depression (siblings) 0.6 0.7 2.6 1.6 0.0 -0.5 -0.3 1.3 -0.1 -0.4 0.9 -1.2 -0.0 -1.4 0.4 1.1 -0.1 -0.1 -0.8 0.7
Pack years adult smoking proportion 0.1 0.2 0.6 0.6 0.0 -0.3 0.5 0.1 0.2 -0.2 0.8 -0.4 0.0 -0.5 0.4 0.4 -0.7 -0.2 -0.5 0.5
Impedance of leg (right) 0.6 3.0 6.7 -1.4 0.0 2.1 0.3 0.7 1.5 -1.8 -1.3 1.7 -1.1 2.6 -2.0 -1.7 -2.4 2.4 2.2 -1.8
Leg fat-free mass (left) 0.4 2.2 5.3 2.3 0.0 -1.4 0.3 0.1 -1.0 0.7 1.9 -0.7 0.7 -2.0 1.4 2.2 1.6 -1.6 -1.7 2.3
Trunk fat percentage 0.3 1.0 4.8 2.2 0.0 1.0 -0.4 2.1 -0.8 0.8 0.1 0.3 1.7 0.5 -0.3 0.3 0.8 -1.2 0.2 0.8
Hand grip strength (right) 0.1 0.2 0.7 -0.2 0.0 -0.0 -0.4 -0.2 0.2 -0.9 -0.5 0.5 -0.4 0.3 0.1 -0.7 -0.5 0.8 0.2 -0.7
Townsend deprivation index at recruitment 1.0 1.4 3.6 0.6 0.0 -1.8 -1.4 -0.7 -0.4 1.2 1.8 -1.6 0.1 -1.9 0.5 1.7 -0.3 -0.6 -1.7 0.8
Current tobacco smoking 0.7 1.1 3.8 1.2 0.0 -0.8 -0.9 0.3 -0.0 0.0 2.0 -1.2 0.3 -1.2 -0.5 1.8 -1.3 -0.1 -1.8 0.8
Average weekly fortified wine intake 1.0 1.1 3.8 0.8 0.0 1.5 1.4 1.3 1.3 -1.7 -0.2 2.0 -0.7 1.0 0.2 0.3 -0.3 1.2 1.1 0.1
Maternal smoking around birth 0.7 1.1 6.2 1.0 0.0 -0.6 0.8 -0.7 1.8 -1.2 1.2 0.4 -0.3 -0.6 -0.9 0.8 -2.5 1.0 -0.6 -0.1
Fed-up feelings 0.4 0.7 3.0 1.1 0.0 -0.4 0.3 0.3 0.3 -0.5 1.7 -0.4 -0.3 -1.1 -0.0 1.7 -0.2 0.2 -1.0 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.2 0.1 0.0 -1.3 -0.1 -1.5 -0.2 0.8 1.1 -1.3 0.3 -1.2 -0.6 1.5 0.1 -0.9 -1.1 1.3
Relative age voice broke 2.0 3.1 8.1 -2.4 0.0 1.8 1.6 1.3 0.9 -1.9 -2.3 2.1 -1.2 1.4 1.5 -2.8 0.4 1.7 2.0 -2.0
Taking other prescription medications 0.6 0.9 4.2 0.1 0.0 1.1 -0.7 2.1 -0.7 1.2 -0.4 0.1 1.7 0.5 0.3 -0.2 1.7 -1.2 -0.1 -0.3
Age when periods started (menarche) 0.3 0.8 3.7 0.4 0.0 -0.4 0.4 -1.4 0.0 -1.9 0.5 1.9 0.5 0.1 0.3 0.1 -0.3 1.1 0.9 0.8
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 4.2 -1.6 0.0 -0.2 1.7 0.8 1.0 -0.4 -2.1 -0.5 -0.4 -1.0 0.1 -1.5 0.3 0.8 0.7 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 12.2 -1.8 0.0 0.4 0.7 0.0 1.8 -0.6 -1.1 -0.1 -2.1 0.4 -3.5 -1.0 -2.0 2.0 0.5 -2.4
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 4.2 0.8 0.0 -1.5 -0.3 0.4 -0.9 0.7 0.5 -1.9 0.1 -2.1 1.0 0.4 0.5 -1.2 -1.0 0.6
Qualifications: CSEs or equivalent 3.1 4.1 9.6 1.1 0.0 -2.0 -3.1 0.0 -2.4 2.9 1.8 -2.1 2.3 -2.1 1.7 1.5 1.3 -2.6 -2.9 1.4
Serious illness, injury or assault to yourself 1.7 2.1 5.2 0.1 0.0 2.0 1.1 1.4 1.5 -2.0 0.1 2.3 -1.0 1.9 -1.6 -0.0 -1.6 2.2 1.6 -0.1
High blood pressure 0.0 0.1 1.0 -0.0 0.0 0.1 1.0 0.4 0.1 -0.2 -0.7 -0.0 0.1 -0.3 0.1 -0.4 0.1 0.4 0.3 -0.4
Hayfever, allergic rhinitis or eczema 1.1 2.3 10.6 -2.0 0.0 0.8 0.7 -0.2 1.6 -1.2 -1.3 0.7 -1.8 1.2 -3.3 -1.4 -2.0 1.6 1.2 -1.8
Multivitamins +/- minerals 0.6 0.8 1.8 0.9 0.0 0.9 1.3 0.4 0.6 -1.3 1.1 1.3 0.4 0.5 -1.3 0.8 -1.3 1.0 0.1 0.3
Stomach or abdominal pain in last month 0.5 0.6 1.8 -0.9 0.0 0.7 -0.3 0.7 1.2 -0.4 -0.4 1.0 -0.2 0.8 -1.3 -0.5 -0.8 0.7 0.8 -1.0
Supplements: Glucosamine 0.3 0.4 2.9 -0.1 0.0 0.8 0.7 1.7 0.4 -0.3 0.5 0.5 0.5 0.1 -0.4 0.7 -0.9 -0.3 0.2 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.9 1.0 0.0 -0.7 0.0 -1.3 -0.4 -0.7 1.1 0.7 0.7 -0.4 0.1 1.0 0.1 -0.3 -0.1 1.4
Medication: Atenolol 0.2 0.2 0.9 0.0 0.0 0.3 0.4 0.1 -0.4 -0.1 -0.4 0.3 0.8 0.4 0.9 -0.1 1.0 -0.1 0.7 0.5
Medication: Levothyroxine sodium 0.4 0.7 3.7 -0.1 0.0 0.1 -0.2 0.4 -1.2 0.9 -1.1 -0.0 1.1 0.1 0.6 -1.0 1.9 -1.3 0.4 -0.0
Sitting height 0.1 1.0 4.0 -0.5 0.0 1.1 1.8 0.6 1.5 -1.0 -0.3 0.4 -2.0 0.8 -0.7 -0.2 -0.8 1.2 0.3 -0.7
Chronic bronchitis/emphysema (father) 0.8 1.0 3.0 -0.0 0.0 -0.5 1.1 -0.2 1.5 -0.8 0.7 -0.6 -1.7 -0.9 -1.6 0.6 -1.5 1.2 -0.4 -0.6
High blood pressure (mother) 0.9 1.2 4.5 -0.7 0.0 1.1 -0.2 2.1 1.1 -0.6 -1.3 0.8 -1.1 0.6 -1.3 -1.2 -0.2 1.4 1.6 -1.5
Body mass index (BMI) 0.8 3.5 11.6 3.4 0.0 -1.8 -0.8 -0.2 -1.5 1.4 2.1 -1.2 2.0 -2.1 0.9 2.5 1.5 -2.1 -1.7 2.8
Impedance of leg (left) 0.5 2.4 5.6 -1.1 0.0 1.9 0.3 0.7 1.3 -1.6 -1.0 1.4 -0.9 2.4 -2.0 -1.6 -2.3 2.1 1.7 -1.8
Leg predicted mass (left) 0.4 2.2 5.1 2.2 0.0 -1.4 0.1 0.1 -1.1 0.8 1.8 -0.8 0.9 -2.0 1.4 2.1 1.6 -1.6 -1.7 2.2
Trunk fat mass 0.3 1.4 8.7 2.9 0.0 0.3 -0.2 1.7 -0.9 0.7 1.1 0.0 1.7 -0.3 0.0 1.4 0.9 -1.3 -0.5 1.6
Waist circumference 0.6 2.0 8.0 2.8 0.0 -0.7 -0.6 1.3 -1.1 1.0 1.5 -0.6 1.8 -1.3 0.8 1.8 1.4 -1.6 -1.1 2.1
Number of incorrect matches in round 0.1 0.2 1.2 0.0 0.0 0.6 -0.8 -0.6 -0.0 0.0 0.1 0.6 0.2 1.1 0.0 0.4 0.6 0.1 0.1 0.2
Past tobacco smoking 0.2 0.4 1.3 -0.1 0.0 0.2 1.1 0.6 0.3 -1.0 -1.0 0.5 -0.6 -0.3 0.3 -0.9 -0.1 0.7 0.4 -1.2
Alcohol usually taken with meals 0.7 1.2 4.5 -0.6 0.0 1.7 1.3 0.2 0.7 -0.6 -1.1 1.7 0.4 1.9 -0.3 -0.7 0.3 1.0 2.1 0.1
Nervous feelings 0.2 0.4 1.6 -1.3 0.0 0.7 0.6 1.0 0.6 -0.7 -0.5 0.5 -0.4 0.3 -0.3 -0.4 -0.7 0.3 0.3 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.2 -0.3 0.0 0.2 -0.5 -0.1 -1.5 0.7 0.6 0.0 1.5 0.3 1.1 0.6 1.1 -1.1 -0.4 1.4
Hearing difficulty/problems with background noise 0.7 1.1 2.4 0.9 0.0 -0.1 -1.3 0.8 -1.5 1.1 0.7 -1.3 1.2 -0.3 1.4 0.8 1.0 -1.5 -1.2 1.0
Hair/balding pattern: Pattern 2 1.4 1.8 5.1 -0.9 0.0 -1.9 -0.5 -1.2 -1.3 1.2 -0.4 -2.2 0.3 -2.0 2.0 -0.4 1.5 -1.7 -1.5 0.3
Had menopause 2.3 2.8 9.2 -0.7 0.0 1.8 1.5 -0.1 1.4 -2.1 -2.1 2.6 -0.7 2.1 -0.5 -2.0 0.1 2.2 3.0 -1.2
Had other major operations 0.4 0.5 2.6 0.9 0.0 0.1 1.1 0.8 0.6 -1.6 0.7 0.3 -0.9 -0.6 -0.3 0.3 -0.7 0.9 -0.3 0.1
Forced vital capacity (FVC) 0.1 0.5 1.6 -0.4 0.0 0.8 1.1 1.2 0.9 -1.0 0.6 0.8 0.2 -0.0 0.2 0.1 -1.3 0.0 -0.4 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 9.4 -2.4 0.0 -0.1 -0.1 -0.5 1.2 -0.1 -1.2 -0.8 -1.5 -0.0 -3.1 -1.1 -1.4 1.5 0.1 -2.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.5 1.2 0.0 0.0 -0.3 -0.7 0.0 -0.1 0.6 -0.3 0.5 0.4 -1.1 0.8 -0.5 0.1 -0.3 0.5
Qualifications: None of the above 1.6 3.5 8.3 1.1 0.0 -1.6 -1.3 -0.7 -2.3 2.5 0.9 -2.5 2.0 -1.5 2.9 0.7 2.4 -2.6 -2.4 1.2
Financial difficulties in last 2 years 1.1 1.4 4.2 1.5 0.0 -1.7 -0.7 -1.0 -0.8 0.2 1.7 -0.6 1.1 -1.8 -0.0 2.0 0.1 -0.7 -1.0 2.0
Mouth/teeth dental problems 0.6 1.0 2.2 -0.5 0.0 1.4 1.1 0.2 0.6 -0.9 -0.8 1.2 -0.4 1.3 -1.5 -0.7 -1.2 1.1 0.8 -1.5
Heart attack 0.2 0.2 0.8 0.2 0.0 0.7 -0.9 0.9 0.4 0.3 -0.1 0.1 0.1 0.6 -0.1 -0.6 -0.5 0.5 0.2 -0.4
Allergy 1.3 2.9 11.8 2.3 0.0 -1.2 0.1 -0.3 -2.0 0.7 2.0 -1.0 1.5 -1.5 3.4 1.8 1.5 -1.6 -2.0 2.3
Pain all over the body in last month 1.5 1.6 5.2 0.8 0.0 -0.8 1.4 0.7 1.5 -1.3 1.3 0.7 -0.2 -1.8 -2.3 1.7 -1.8 1.0 0.4 0.7
Diabetes (self-reported) 0.4 0.6 2.1 0.1 0.0 -1.3 -0.0 -1.4 -0.0 0.4 -0.3 -0.6 -1.3 -1.2 0.8 -0.2 1.0 -0.5 -0.2 -0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.3 0.2 0.0 0.2 -0.6 0.2 -0.3 -0.6 -0.3 -0.1 -0.3 0.3 -1.0 -0.1 -0.4 1.1 0.4 0.1
Medication: Ramipril 0.3 0.3 1.4 0.8 0.0 -1.1 -0.8 0.1 -0.9 0.0 -0.4 -0.8 0.0 -1.2 0.3 -0.4 0.3 -0.2 -0.1 -0.1
Medication: Simvastatin 0.8 1.1 4.5 -1.2 0.0 -0.4 -1.4 -0.4 -0.8 1.1 -2.1 -0.4 0.4 0.1 -0.1 -2.0 1.2 -0.3 1.0 -1.6
Fluid intelligence score 0.8 1.6 5.0 -0.6 0.0 2.2 0.7 2.1 1.1 -1.2 -0.7 1.1 -1.6 1.8 -0.9 -0.7 -1.3 1.2 1.3 -1.0
Illnesses of siblings 0.4 0.5 4.4 -0.6 0.0 0.1 -0.7 0.8 0.1 0.3 -0.9 -0.1 0.4 -0.1 -2.1 -0.5 -0.5 0.3 1.0 -0.8
Neuroticism score 0.3 0.5 2.5 0.3 0.0 -0.2 0.1 1.0 0.2 -0.2 1.5 -0.7 -0.1 -1.0 -0.3 1.6 -0.2 -0.0 -0.8 1.0
Weight 0.5 2.7 10.8 3.3 0.0 -1.1 0.1 0.5 -1.0 0.8 2.2 -0.8 1.5 -1.8 0.7 2.5 1.2 -1.6 -1.6 2.6
Impedance of arm (right) 1.1 5.3 15.3 -2.4 0.0 3.9 0.8 2.7 1.1 -0.5 -3.0 1.7 -0.9 3.9 -1.6 -3.0 -1.3 1.1 2.5 -3.3
Arm fat percentage (right) 0.5 1.8 7.6 2.8 0.0 -0.4 -0.6 1.3 -1.2 1.5 1.0 -0.8 2.0 -1.0 0.1 1.5 1.1 -1.9 -0.9 1.6
Trunk fat-free mass 0.8 4.5 13.8 2.8 0.0 -2.4 0.3 -1.0 -1.0 0.2 3.5 -1.1 0.8 -2.9 1.5 3.7 0.9 -1.2 -2.6 3.5
Hip circumference 0.4 1.8 7.0 2.6 0.0 -0.8 -0.3 0.5 -1.1 1.3 1.5 -1.1 1.4 -1.3 -0.0 1.8 1.0 -1.6 -1.3 2.1
Time employed in main current job 0.3 0.4 1.1 -1.0 0.0 0.9 0.3 -0.0 -0.0 0.5 -0.9 0.0 -0.3 1.0 0.0 -1.0 0.3 -0.3 -0.2 -1.1
Alcohol intake versus 10 years previously 0.7 1.1 3.3 1.6 0.0 -0.7 -0.4 0.8 -0.4 0.4 1.7 -1.4 -0.0 -1.3 -0.1 1.8 -0.3 -0.8 -1.4 1.4
Father’s age at death 0.2 0.2 1.0 -0.3 0.0 0.7 0.5 -0.4 0.0 -0.4 -0.4 0.9 0.3 1.0 0.0 -0.3 0.4 -0.1 0.6 0.1
Worrier / anxious feelings 0.1 0.2 1.4 0.1 0.0 0.8 -0.1 1.2 0.0 -0.4 -0.3 0.4 -0.2 0.5 -0.5 -0.2 -0.2 0.7 0.5 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.6 -1.3 0.0 0.7 0.8 1.6 0.7 0.1 -0.6 -0.7 -0.8 -0.0 -1.2 -0.1 0.1 0.5 1.0 -0.0
Falls in the last year 1.1 1.5 5.5 2.2 0.0 -0.2 0.1 0.2 -0.9 0.9 1.9 -1.2 0.6 -0.2 0.9 2.1 0.4 -1.4 -1.1 2.4
Hair/balding pattern: Pattern 3 0.3 0.5 2.7 1.6 0.0 -0.4 -0.5 -0.4 -0.7 0.1 0.9 0.3 0.2 -0.2 0.7 0.9 0.5 -0.7 -1.0 0.8
Number of live births 0.3 0.5 1.3 0.1 0.0 -0.8 1.1 -0.4 0.7 -1.1 0.8 0.6 0.7 -1.1 -0.5 0.4 -0.7 0.6 -0.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 2.0 -0.4 0.0 0.3 1.4 0.2 0.9 -0.6 0.7 0.2 -0.2 -0.1 0.4 0.3 -1.2 -0.1 -0.4 0.5
Pulse rate 0.9 1.6 4.3 -0.6 0.0 1.8 0.3 1.9 0.2 -0.7 -2.1 1.9 -0.1 1.4 -0.3 -1.8 0.3 -0.1 2.0 -1.4
Happiness 1.1 1.3 3.8 0.4 0.0 -0.7 -1.3 0.1 -1.5 1.2 -0.5 -1.0 1.5 -0.8 1.8 -0.6 1.8 -1.9 -1.2 -0.0
Noisy workplace 0.1 0.2 0.8 0.5 0.0 -0.5 0.5 0.1 0.3 -0.4 -0.1 -0.9 -0.6 -0.6 0.1 -0.2 -0.7 -0.0 -0.3 -0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.2 -0.5 0.0 1.6 -0.2 0.7 0.6 -0.6 -1.6 1.6 -0.4 1.8 -0.7 -1.6 0.1 1.1 1.7 -1.7
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 2.2 0.5 0.0 0.8 0.2 0.3 -0.4 0.2 -0.2 1.0 1.5 1.1 0.5 -0.2 1.1 -0.1 0.6 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 3.6 1.3 0.0 -0.7 0.2 -1.2 -0.6 0.4 0.5 -0.6 -0.0 -0.4 1.8 0.7 1.9 -1.2 -0.4 1.5
Asthma 0.3 0.5 1.9 -0.5 0.0 0.6 -1.4 -0.5 0.2 1.2 -0.9 -0.1 0.6 1.2 -1.0 -0.7 0.4 -0.4 0.2 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.6 -0.6 0.0 -1.0 -1.5 -0.3 -0.5 1.9 0.5 -2.1 -0.2 -0.8 -0.2 0.5 0.3 -1.3 -1.4 0.2
Medication: Cholesterol lowering 0.2 0.4 1.2 -1.1 0.0 -0.2 -0.6 0.3 -0.8 0.6 -1.1 -0.6 0.4 -0.1 0.2 -0.9 0.7 -0.2 0.4 -0.5
Depression (self-reported) 0.5 0.6 2.5 0.9 0.0 0.5 1.3 -0.2 0.5 -1.0 1.1 1.6 0.8 0.4 0.4 1.0 0.1 -0.4 0.3 0.9
Medication: Lansoprazole 0.7 0.8 4.6 1.2 0.0 0.3 0.1 0.8 -0.7 0.4 -0.0 0.6 1.5 -0.1 1.6 -0.1 2.1 -1.0 0.0 0.3
Prospective memory result 0.3 0.4 2.2 -0.1 0.0 0.2 0.1 -0.0 -0.5 1.5 -0.6 -0.6 -0.4 0.3 -0.0 -0.8 1.0 -0.8 0.1 -0.8
Lung cancer (father) 0.7 0.8 3.7 0.8 0.0 -1.1 -0.0 -0.5 0.6 -0.2 0.8 -0.7 -1.4 -1.4 -1.9 0.6 -0.9 0.3 -0.8 -0.2
Illnesses of mother 0.3 0.3 1.1 -0.3 0.0 -0.7 0.4 -0.7 -0.5 0.7 0.2 -0.7 0.3 -0.7 0.5 0.2 0.4 -1.1 -0.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.4 0.7 0.0 0.2 1.0 0.4 0.1 -0.3 1.2 -0.4 -0.6 -0.3 0.8 0.8 -0.5 -0.8 -1.0 0.9
Pulse wave Arterial Stiffness index 2.0 2.3 6.2 -2.3 0.0 2.1 0.4 1.7 0.0 0.1 -2.4 1.4 0.6 1.9 0.9 -2.5 0.8 0.6 1.5 -2.1
Impedance of arm (left) 1.8 8.5 20.2 -2.9 0.0 4.5 1.1 3.0 1.8 -1.2 -4.1 2.4 -1.3 4.4 -2.3 -4.1 -1.6 1.9 3.4 -4.2
Arm fat mass (right) 0.6 2.6 9.8 3.1 0.0 -1.1 -0.4 0.9 -1.3 1.3 1.8 -1.2 1.9 -1.8 0.5 2.2 1.3 -2.0 -1.5 2.3
Trunk predicted mass 0.7 4.3 13.0 2.7 0.0 -2.4 0.3 -1.0 -1.1 0.2 3.4 -1.1 0.8 -2.9 1.5 3.6 1.0 -1.2 -2.5 3.4
Standing height 0.1 0.8 2.8 0.4 0.0 1.5 1.7 1.6 0.8 -1.1 0.6 0.9 -0.7 0.8 -0.1 0.6 -0.5 0.8 0.1 0.2
Length of working week for main job 0.3 0.3 1.4 0.3 0.0 0.4 -0.7 0.3 0.1 0.5 -0.2 -0.2 1.0 0.5 1.2 -0.5 -0.1 -0.1 -0.5 -0.5
Exposure to tobacco smoke at home 1.3 1.5 6.2 2.5 0.0 -1.6 -1.6 -1.3 -1.1 0.5 1.4 -0.3 1.4 -1.2 0.5 0.9 0.4 -1.3 -1.3 0.9
Breastfed as a baby 1.1 1.4 8.2 0.2 0.0 0.9 0.4 -0.5 1.2 -1.7 -0.8 2.9 -0.0 1.5 -1.4 -0.8 -0.2 1.3 1.6 -0.6
Tense / ‘highly strung’ 0.4 0.7 2.5 0.9 0.0 -0.7 0.5 0.1 -0.8 -0.4 1.2 -0.8 0.6 -1.2 0.7 1.2 0.5 -0.8 -0.9 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 2.2 -0.0 0.0 0.4 -0.0 1.5 0.4 -0.6 -0.2 0.5 0.2 -0.2 -0.6 -0.4 -0.6 0.0 0.4 -0.5
Hair/balding pattern: Pattern 4 0.7 1.8 3.8 -0.8 0.0 1.8 2.0 1.0 1.6 -1.2 -1.1 1.7 -0.1 1.6 -1.4 -1.0 -1.0 1.5 1.7 -1.2
Birth weight of first child 0.3 0.5 2.3 -0.6 0.0 -0.7 -1.5 0.2 -0.7 0.1 -0.7 0.3 0.0 -1.0 0.6 -0.6 1.5 -0.4 0.0 -0.4
Peak expiratory flow (PEF) 0.4 0.8 4.6 -2.1 0.0 -0.3 0.2 -0.8 1.0 0.0 -0.1 -0.9 -0.9 -0.2 -0.9 -0.4 -2.1 0.2 -0.7 -0.8
Pulse wave reflection index 1.6 2.0 4.2 -1.4 0.0 1.3 2.0 0.9 1.7 -1.9 -1.3 1.4 -1.4 0.8 0.1 -1.6 -1.0 2.0 1.2 -1.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.8 -0.7 0.0 -0.4 0.2 0.3 -0.0 0.5 -0.3 -1.4 0.6 -0.6 0.1 -0.1 0.5 0.1 -0.1 -0.0
Loud music exposure frequency 2.6 2.8 8.8 -0.3 0.0 -3.0 -2.4 -1.1 -2.3 1.3 -0.0 -2.5 1.2 -2.9 1.1 -0.0 1.4 -1.8 -1.8 0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 2.0 0.9 0.0 0.8 -0.0 0.6 0.9 -1.1 0.7 1.4 -0.3 1.0 -1.4 0.9 -1.4 1.2 1.0 0.5
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 4.8 1.2 0.0 -1.2 -1.8 0.6 -1.9 1.6 0.6 -1.2 2.2 -1.3 1.7 0.2 1.7 -2.2 -1.1 1.1
Blood clot in the leg (DVT) 0.7 0.9 2.6 -0.7 0.0 1.4 -0.1 0.6 1.1 -0.1 -0.7 1.0 -0.5 1.6 -1.1 -0.6 -0.2 1.3 1.4 -0.9
Medication: Paracetamol 0.3 0.6 3.9 -0.4 0.0 1.8 0.2 0.9 0.0 0.7 0.6 0.0 -0.0 2.0 -0.2 0.6 -0.3 -0.0 0.1 0.4
Headache pain in last month 0.7 1.2 3.9 1.4 0.0 0.9 -1.0 1.0 -1.0 0.9 1.5 -0.4 0.0 0.8 1.1 2.0 1.0 -0.9 -0.9 1.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 -0.9 0.0 0.6 1.1 0.0 0.9 -0.8 -0.2 0.7 -0.8 0.4 -0.1 -0.3 -0.7 0.9 0.5 -0.4
Glaucoma (self-reported) 0.3 0.3 1.6 -0.5 0.0 1.1 1.2 1.3 0.1 0.5 0.2 -0.4 0.3 0.3 0.1 0.3 0.3 -0.5 -0.2 0.1
Gout (self-reported) 1.2 1.6 7.7 2.2 0.0 -1.9 0.5 0.1 -0.1 -0.3 1.7 -1.0 0.4 -2.8 0.2 1.6 -0.6 -0.7 -1.6 1.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.8 1.0 0.0 -1.0 -0.9 -0.4 -1.8 1.7 0.9 -1.1 1.4 -1.0 0.6 1.0 1.8 -1.9 -1.2 1.6
Medication: Amlodipine 0.4 0.6 2.4 -0.7 0.0 0.0 1.3 0.3 -0.3 0.3 -1.5 -0.5 -0.4 -0.3 0.3 -1.1 1.6 -0.6 1.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.9 -1.8 0.0 0.1 -0.6 0.3 0.8 0.4 -1.6 -0.1 -0.4 0.3 -1.7 -1.6 -0.6 0.3 0.4 -2.0
Birth weight 0.5 1.0 6.4 2.5 0.0 -0.9 -0.0 -1.0 0.5 -1.3 1.4 0.7 -0.0 -0.9 0.2 1.4 -0.7 0.5 -1.1 0.5
Chronic bronchitis/emphysema (mother) 2.6 3.0 8.2 2.2 0.0 -2.1 -2.9 -0.3 -1.1 0.8 2.4 -1.3 1.8 -2.1 1.1 2.3 0.3 -1.1 -1.7 2.4
High blood pressure (siblings) 0.2 0.2 1.2 1.1 0.0 -0.5 0.4 -0.5 0.2 -0.7 0.4 0.4 -0.2 -0.6 0.7 0.3 0.2 0.3 -0.5 0.2
Forced vital capacity (FVC), Best measure 0.1 0.3 1.0 0.6 0.0 0.5 0.5 0.9 0.1 -0.4 1.0 0.2 -0.4 -0.2 0.3 0.5 -0.4 -0.7 -0.9 0.5
Body fat percentage 0.3 1.2 6.9 2.6 0.0 0.5 -0.4 1.6 -0.8 0.7 0.7 0.2 1.9 0.1 -0.2 0.9 0.7 -1.1 -0.1 1.3
Leg fat percentage (right) 0.6 2.1 12.5 3.5 0.0 -0.9 -0.7 0.5 -0.8 0.3 2.0 -0.3 1.7 -1.1 0.3 2.1 0.5 -1.0 -0.9 2.3
Arm fat-free mass (right) 0.6 3.0 7.9 2.4 0.0 -2.1 0.3 -0.8 -1.0 0.3 2.6 -1.2 0.8 -2.5 1.3 2.7 1.1 -1.1 -2.1 2.8
Exposure to tobacco smoke outside home 0.4 0.5 3.3 1.8 0.0 0.2 -1.1 0.9 -0.1 -0.1 0.8 0.5 -0.4 0.1 -0.3 1.0 -0.2 -0.1 0.5 1.2
Comparative body size at age 10 1.6 4.4 20.5 3.0 0.0 -1.6 -0.2 -0.9 0.3 -0.2 4.2 -0.3 0.3 -1.9 -0.1 4.5 -1.9 -0.3 -2.5 3.1
Number of full brothers 2.0 2.5 7.5 2.2 0.0 -2.1 -0.2 -1.7 -0.4 0.1 2.7 -1.0 1.3 -2.0 0.9 2.2 -0.3 -0.7 -2.2 2.2
Worry too long after embarrassment 0.7 1.2 5.5 1.8 0.0 -0.7 -1.0 -0.4 -0.2 0.2 2.1 -0.7 0.0 -0.7 -0.6 2.3 -0.7 0.0 -1.4 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.9 1.4 0.0 -1.1 -0.5 -0.4 -0.9 -0.0 1.6 -0.9 1.7 -1.4 1.7 1.1 0.4 -1.3 -1.7 1.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.8 -0.8 0.0 0.0 -0.9 0.4 0.2 0.4 -0.3 -0.1 0.3 -0.1 -0.5 -0.3 0.1 0.3 0.3 -0.4
Number of children fathered 0.7 0.8 2.6 0.5 0.0 0.5 1.2 0.5 1.1 -0.6 1.5 -0.2 -0.6 0.3 -0.3 1.6 -1.4 0.8 -0.6 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 5.0 0.8 0.0 -1.0 -1.6 -2.2 -0.6 0.7 0.7 0.2 1.0 -0.2 -0.0 0.5 0.0 -1.1 -0.6 0.8
Age at first live birth 1.0 1.7 5.1 -1.2 0.0 1.4 1.9 -0.3 1.3 -2.1 -0.8 2.3 -1.6 1.7 -0.3 -0.7 -0.7 0.9 1.5 -0.2
Pulse wave peak to peak time 1.9 2.3 6.7 2.4 0.0 -1.9 -0.3 -1.7 0.1 -0.3 2.5 -1.3 -0.8 -1.7 -0.8 2.6 -0.9 -0.4 -1.5 2.1
Health satisfaction 0.3 0.4 1.5 -0.2 0.0 -0.9 0.3 -1.0 -0.2 0.6 -0.6 -0.6 0.4 -0.8 0.1 -0.3 1.2 -0.9 -0.0 0.2
Shortness of breath walking on level ground 0.7 0.8 2.1 1.0 0.0 -1.3 -1.3 -1.0 -0.6 1.2 0.3 -0.5 1.4 -0.8 -0.0 0.8 1.1 -0.5 -0.3 1.0
Qualifications: College or University degree 1.3 4.1 7.2 -1.6 0.0 2.3 1.6 0.4 2.3 -2.2 -1.9 2.0 -2.3 2.5 -2.3 -1.7 -1.9 2.7 2.4 -2.1
Eye problems/disorders: None of the above 0.5 0.6 2.2 1.2 0.0 -0.1 0.1 -0.1 -0.5 -0.1 1.2 0.3 0.9 -0.1 0.6 1.4 0.1 -0.4 -0.6 1.5
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.7 -0.4 0.0 -0.7 -0.3 0.5 0.4 -0.7 0.5 -0.5 -1.1 -1.3 0.3 0.5 -0.4 0.6 -0.3 0.5
Emphysema/chronic bronchitis 0.3 0.4 1.3 -0.6 0.0 0.0 0.4 1.2 1.1 0.1 -0.6 -0.1 -0.2 -0.7 -1.1 -0.4 0.1 0.3 0.7 -0.7
Medication for pain relief, constipation, heartburn 0.5 0.9 3.3 1.5 0.0 -1.6 -0.0 -0.9 -0.5 -0.5 0.8 -0.1 0.0 -1.8 1.4 0.4 0.6 -0.6 -0.8 0.8
Neck or shoulder pain in last month 0.4 0.5 2.0 0.5 0.0 1.1 -1.4 1.4 0.5 0.6 -0.1 -0.0 -0.4 1.1 -0.5 0.0 0.1 0.9 0.4 -0.3
Medication: Blood pressure 0.1 0.1 0.7 0.8 0.0 -0.3 0.2 -0.1 -0.4 -0.1 -0.1 -0.6 -0.2 -0.3 -0.1 -0.0 0.3 -0.2 -0.2 0.1
Angina (self-reported) 1.3 1.7 3.5 -1.9 0.0 1.8 0.7 1.2 1.1 -0.9 -1.5 1.3 -0.5 1.6 -1.1 -1.5 -1.0 1.5 1.6 -1.3
Migraine (self-reported) 0.4 0.5 5.6 0.8 0.0 0.6 -0.1 2.4 -0.3 -0.2 0.7 -0.4 -0.1 -0.4 -0.5 0.8 -0.3 0.4 -0.2 0.3
Medication: Ibuprofen 0.6 0.8 3.9 0.1 0.0 -0.9 -0.4 -0.4 -0.4 1.1 1.0 -2.0 -0.6 -0.9 0.0 1.0 0.1 -0.9 -1.4 0.6
Medication: Allopurinol 1.7 2.3 8.2 2.1 0.0 -2.1 0.5 -0.3 -0.3 -0.3 2.3 -0.8 0.7 -2.9 0.4 2.5 -0.1 -1.0 -1.5 2.2
Medication: Omeprazole 2.9 3.4 7.1 -1.3 0.0 2.3 -0.7 1.9 1.5 -0.9 -2.0 2.5 -0.8 2.4 -2.6 -1.7 -1.2 2.2 2.7 -2.1
Medication: Seretide 50 evohaler 0.6 0.7 2.1 -0.9 0.0 1.1 0.3 0.9 1.4 -0.2 -0.5 0.9 -0.4 1.0 -1.2 -0.0 -1.0 1.0 1.4 -0.5
Mean time to correctly identify matches 0.2 0.4 1.8 0.5 0.0 0.4 -0.7 0.5 0.1 0.8 -1.3 0.6 0.2 0.5 -0.4 -0.7 1.0 0.0 1.1 -0.7
Heart disease (mother) 1.4 1.7 6.5 -1.0 0.0 2.2 -0.1 0.9 0.2 -0.5 -2.0 1.5 0.2 2.6 -0.1 -2.0 0.2 0.8 1.6 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.1 -0.2 0.0 0.4 0.8 0.5 0.4 -0.6 -0.2 1.0 0.8 0.2 0.2 -0.6 -0.9 -0.0 -0.4 -0.6
Whole body fat mass 0.4 1.9 9.0 3.0 0.0 -0.3 -0.2 1.4 -1.1 0.9 1.4 -0.5 2.0 -0.9 0.4 1.7 1.1 -1.5 -0.9 2.1
Leg fat mass (right) 0.7 2.9 14.9 3.9 0.0 -1.2 -0.3 0.5 -0.9 0.5 2.5 -0.5 1.7 -1.8 0.7 2.6 0.8 -1.3 -1.4 2.7
Arm predicted mass (right) 0.6 2.8 7.1 2.3 0.0 -2.0 0.2 -0.4 -0.9 0.3 2.6 -1.1 0.9 -2.6 1.3 2.7 1.0 -1.0 -2.2 2.6
Pulse rate, automated reading 0.5 1.7 5.9 -0.1 0.0 1.3 -0.7 1.1 -0.8 0.7 -1.9 1.5 1.0 1.3 1.8 -1.9 2.4 -1.3 1.2 -1.0
Alcohol intake frequency. 0.6 1.5 4.7 0.7 0.0 -1.1 -1.0 -0.3 -1.2 1.7 0.8 -2.2 0.3 -1.2 1.5 1.0 1.2 -1.4 -1.9 0.8
Comparative height size at age 10 0.1 0.4 2.3 0.2 0.0 1.5 0.5 1.5 -0.0 0.2 -0.1 0.2 0.5 1.3 -0.1 0.1 0.3 -0.1 -0.0 0.0
Number of full sisters 0.3 0.4 1.0 0.8 0.0 -0.8 -1.0 0.4 -0.4 0.2 0.5 -0.5 1.0 -1.0 0.7 0.5 0.1 -0.3 -1.0 0.3
Suffer from ‘nerves’ 0.9 1.3 3.1 0.9 0.0 -1.4 -0.7 -0.8 -0.7 0.8 1.7 -1.1 0.9 -1.4 0.8 1.8 0.4 -1.4 -1.6 1.6
Overall health rating 0.1 0.3 1.8 0.0 0.0 0.2 0.3 0.8 -0.0 0.4 0.1 -1.0 -0.5 -0.3 1.4 0.0 0.6 -0.3 -0.5 0.1
Chest pain or discomfort 1.6 2.3 10.1 0.5 0.0 0.4 0.7 0.3 2.7 -1.1 1.3 0.8 -1.9 0.2 -3.2 1.5 -2.5 2.0 1.2 0.6
Had major operations 0.4 0.5 1.6 -0.6 0.0 0.8 0.6 0.9 0.5 -0.7 -0.8 -0.1 0.4 0.5 -1.2 -0.7 -0.3 1.2 0.9 -0.6
Age at last live birth 2.1 3.0 8.8 -0.9 0.0 1.1 2.4 -0.8 2.1 -3.0 -0.1 2.9 -1.8 1.5 -1.9 0.1 -1.7 2.0 2.1 0.2
Family relationship satisfaction 1.2 1.4 5.4 1.7 0.0 -0.8 -1.5 -0.4 -1.9 0.4 0.1 -0.4 2.3 -0.9 1.6 0.1 1.7 -1.3 -0.8 0.7
Leg pain on walking 1.0 1.3 4.1 1.7 0.0 -0.9 -0.3 -0.6 -0.8 0.7 1.8 -1.1 0.3 -1.0 0.2 2.0 0.4 -1.0 -1.5 2.0
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.9 2.1 0.0 -2.2 0.1 -1.4 -0.0 -0.3 1.8 -0.2 0.5 -2.1 -0.8 2.2 -0.1 -0.2 -0.3 2.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 2.4 1.4 0.0 -0.1 -0.2 0.3 -0.0 -0.4 0.9 1.1 1.5 -0.4 0.1 0.7 0.2 -0.0 -0.2 0.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.7 -0.4 0.0 -0.8 -0.5 -0.8 -0.4 0.9 0.3 -0.8 -0.0 -0.7 -0.2 0.5 -0.1 -1.3 -0.8 0.2
Medication: Aspirin 0.3 0.4 1.7 -0.8 0.0 0.6 1.3 -0.3 0.0 -0.6 -1.1 0.2 -0.3 0.6 -0.5 -0.8 0.1 0.3 0.8 -0.3
Supplements: Vitamin C 0.6 0.7 3.2 1.0 0.0 0.2 -0.3 1.0 -0.3 -0.5 1.8 0.4 1.4 -0.4 -0.7 1.4 -0.8 0.3 -0.9 0.7
Knee pain experienced in last month 2.1 3.3 11.3 1.8 0.0 -2.6 -1.3 0.4 -1.0 1.2 2.3 -1.8 1.7 -3.4 1.0 2.1 0.4 -2.1 -2.5 1.6
Hypertension (Self-reported) 0.1 0.2 0.7 0.1 0.0 -0.1 0.8 0.1 -0.4 0.2 -0.8 -0.7 0.1 -0.4 0.2 -0.5 0.5 -0.1 -0.0 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 4.1 1.4 0.0 0.7 -0.2 1.1 1.1 -0.7 0.4 2.0 0.2 0.6 -1.2 0.4 -0.2 0.8 1.1 -0.2
Illnesses of father: Heart disease 0.7 1.0 1.8 1.2 0.0 -0.9 -1.0 -0.6 -1.1 1.0 0.6 -0.9 0.9 -0.8 1.1 1.0 1.2 -1.3 -1.2 1.3
Illnesses of siblings: Diabetes 0.7 0.8 2.5 1.0 0.0 -1.0 1.2 -0.7 -0.0 -0.8 1.6 0.1 -0.2 -1.2 1.4 0.9 -0.6 -0.4 -1.2 0.9
Smoking status: Previous 0.2 0.3 1.3 -0.5 0.0 -0.2 -0.9 -0.4 -0.2 0.9 0.3 -0.1 1.1 0.3 -0.2 0.3 0.3 -0.6 0.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 5.0 -0.6 0.0 0.5 2.2 0.8 1.1 -1.2 0.0 -0.3 -1.3 -0.3 -1.1 0.0 -1.4 0.8 -0.1 -0.5
Whole body fat-free mass 0.7 3.8 10.1 2.7 0.0 -2.2 0.2 -0.6 -1.2 0.6 2.9 -1.2 0.9 -2.8 1.6 3.2 1.3 -1.6 -2.4 3.1
Leg fat-free mass (right) 0.5 2.5 5.1 2.2 0.0 -1.5 0.3 0.0 -1.2 0.8 1.9 -1.0 0.9 -2.2 1.6 2.2 1.7 -1.8 -2.0 2.2
Arm fat percentage (left) 0.3 1.3 6.1 2.5 0.0 -0.2 -0.5 1.4 -1.0 1.2 0.5 -0.6 1.9 -0.7 -0.1 0.9 1.0 -1.6 -0.5 1.1
Average weekly red wine intake 0.5 0.8 3.0 0.1 0.0 0.3 0.8 -0.3 1.2 -0.9 0.2 1.4 0.5 0.4 -1.7 0.2 -1.0 1.4 1.2 0.1
Handedness (chirality/laterality): Left-handed 1.5 1.7 6.6 2.6 0.0 -1.5 -0.5 -1.0 -1.0 -0.6 1.6 0.2 1.6 -1.6 1.2 1.6 0.5 -0.6 -1.1 2.1
Mood swings 1.0 1.8 5.2 -0.1 0.0 -1.8 -1.0 -0.7 -0.8 1.0 2.1 -2.3 -0.0 -1.9 0.3 1.8 -0.3 -0.9 -2.1 1.2
Loneliness, isolation 1.8 2.5 7.1 0.4 0.0 -1.7 -1.4 -0.4 -1.9 2.0 0.4 -2.7 1.2 -2.0 1.3 0.7 2.1 -2.5 -1.9 1.1
Long-standing illness, disability or infirmity 0.6 0.9 5.2 -1.1 0.0 1.0 0.2 1.3 0.5 -0.1 -1.3 -0.3 -2.3 0.6 -0.3 -1.1 0.1 0.8 0.4 -1.5
Ever had bowel cancer screening 0.8 1.0 3.5 1.0 0.0 1.4 1.4 -0.1 -0.0 -0.8 -0.0 1.9 1.5 1.6 0.2 0.6 0.6 0.4 0.9 1.0
Diabetes diagnosed by doctor 0.4 0.7 1.7 0.4 0.0 -1.3 -0.3 -0.9 -0.4 0.7 -0.4 -0.8 -1.1 -1.3 1.3 -0.4 1.3 -0.7 -0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.7 1.3 0.0 -0.7 -0.4 0.4 0.0 -0.3 1.3 -0.3 0.0 -1.3 -0.0 1.1 -0.2 -0.1 -1.2 0.5
Friendships satisfaction 0.1 0.1 0.7 -0.1 0.0 0.1 -0.4 -0.1 -0.3 -0.2 -0.0 -0.2 0.6 0.3 0.8 -0.1 0.3 0.1 -0.1 0.1
Qualifications: nursing, teaching 2.1 3.2 5.7 -0.7 0.0 2.1 1.3 1.5 1.3 -1.9 -2.2 2.0 -1.5 1.8 -2.1 -2.4 -1.0 1.9 2.4 -2.3
Commuting to job workplace: Walk 1.2 1.3 5.2 -1.8 0.0 1.0 0.3 0.1 0.2 0.4 -2.3 0.4 -1.2 1.3 -0.1 -2.1 0.4 0.1 1.4 -1.7
Eye problems/disorders: Cataract 0.8 0.9 2.1 -1.4 0.0 0.5 -0.9 1.1 -0.9 1.1 -1.5 -0.2 1.1 0.5 0.7 -1.4 1.2 -0.6 0.4 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.5 -1.5 0.0 0.9 1.0 0.1 1.8 -0.8 0.4 0.5 -1.3 1.2 -0.6 -0.0 -1.9 1.5 0.3 -0.5
Medication for cholesterol 0.4 0.6 2.1 0.6 0.0 -0.3 -0.7 -0.4 -0.6 0.5 1.4 -1.2 -0.0 0.0 0.6 1.1 -0.3 -0.5 -1.4 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.0 0.0 0.0 1.1 0.9 1.4 0.7 -0.8 0.4 0.3 0.4 0.7 -1.0 0.3 -1.3 0.7 0.2 -0.3
Back pain experienced in last month 0.8 1.2 4.2 0.6 0.0 -1.6 0.0 -0.9 -1.1 1.3 0.3 -2.0 0.1 -1.6 1.3 0.4 1.2 -1.2 -1.3 0.8
Mineral and other dietary supplements 0.4 0.6 3.9 0.6 0.0 -0.8 -0.1 -0.9 0.5 -0.5 0.4 -0.9 -2.0 -0.7 -0.3 0.3 -0.5 0.9 -0.6 -0.2
Breast cancer (self-reported) 0.5 0.6 1.6 -0.9 0.0 0.7 -1.0 0.9 0.4 -0.1 -0.5 1.3 -0.8 0.8 0.2 -1.1 0.1 0.4 1.1 -0.9
Asthma (self-reported) 0.3 0.5 1.5 -0.6 0.0 0.7 -1.2 -0.5 0.2 1.0 -1.0 0.0 0.5 1.2 -0.9 -0.7 0.4 -0.3 0.3 -0.7
Osteoporosis (self-reported) 0.6 0.7 3.1 -0.7 0.0 1.8 -0.1 1.4 -0.2 0.4 -0.9 0.6 0.1 1.6 0.2 -0.6 0.6 0.2 0.9 -0.7
Osteoarthritis (self-reported) 0.3 0.3 1.4 0.8 0.0 -0.3 -0.4 0.7 -0.4 1.2 0.3 -1.0 -0.0 -0.4 0.3 0.4 0.5 -0.6 -0.8 -0.1
Medication: Aspirin 0.2 0.3 1.0 -0.3 0.0 0.8 0.9 -0.1 -0.2 -0.5 -1.0 0.2 -0.5 0.9 -0.3 -0.6 0.3 0.2 0.9 0.0
Medication: Gliclazide 0.7 0.8 2.9 -0.5 0.0 -1.3 0.5 -0.8 -1.2 1.0 -0.3 -1.7 -0.1 -1.5 0.9 -0.2 0.8 -0.8 -1.0 -0.3
Illnesses of father: None of the above (group 1) 0.2 0.2 0.7 -0.2 0.0 0.1 0.4 0.6 0.0 0.2 0.9 0.3 0.8 -0.3 0.4 0.8 0.2 -0.7 -0.6 0.6
Smoking status: Current 0.7 1.2 3.8 1.2 0.0 -0.8 -1.2 0.3 -0.3 0.1 2.0 -1.3 0.2 -1.1 -0.2 1.9 -1.2 -0.3 -1.9 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 3.1 0.6 0.0 0.5 1.8 -0.6 0.7 -0.8 0.7 0.2 -1.0 0.5 1.7 0.6 -0.1 -0.3 -0.4 1.1
Whole body water mass 0.7 3.8 10.5 2.6 0.0 -2.2 0.2 -0.6 -1.1 0.6 3.0 -1.2 1.0 -2.8 1.5 3.2 1.3 -1.6 -2.4 3.1
Leg predicted mass (right) 0.5 2.7 5.6 2.3 0.0 -1.5 0.2 0.0 -1.3 0.9 2.0 -1.0 1.0 -2.2 1.6 2.2 1.8 -1.9 -2.0 2.4
Arm fat mass (left) 0.6 2.6 10.3 3.2 0.0 -1.0 -0.5 1.0 -1.5 1.4 1.4 -1.1 2.1 -1.6 0.7 1.9 1.6 -2.1 -1.3 2.3
Number of self-reported non-cancer illnesses 0.4 0.7 2.0 -0.5 0.0 1.0 -0.2 1.3 0.1 -0.2 -1.4 0.6 0.3 0.7 -0.2 -1.4 1.0 0.9 1.1 -1.3
Average weekly champagne plus white wine intake 0.7 0.9 3.0 -0.9 0.0 0.9 -0.4 0.0 0.6 -0.2 -1.2 1.7 0.7 1.3 -1.1 -1.3 0.4 0.4 1.7 -0.9
Miserableness 0.7 1.3 4.0 1.3 0.0 -0.8 0.2 -0.1 -0.5 -0.3 1.9 -1.4 -0.1 -1.2 1.1 2.0 -0.2 -0.8 -1.6 1.8
Guilty feelings 0.2 0.3 1.8 -0.3 0.0 -0.9 0.2 -0.2 -0.1 -0.7 0.6 -0.8 0.0 -1.4 -0.6 0.4 -0.4 0.4 -0.8 0.2
Wears glasses or contact lenses 1.0 1.1 4.3 0.2 0.0 2.1 0.9 1.6 0.8 -0.7 0.4 1.8 1.0 1.7 -0.4 0.4 -0.4 0.5 1.1 0.5
Ever taken oral contraceptive pill 0.8 0.9 4.0 0.0 0.0 1.0 0.1 1.5 1.1 -0.8 -0.4 0.3 -1.1 0.7 -2.0 -0.5 -1.2 0.9 0.8 -0.8
Hearing aid user 0.4 0.4 1.8 1.0 0.0 0.4 -0.4 0.5 -1.0 0.8 -0.6 -0.5 0.5 0.4 0.2 -0.3 1.1 -1.4 0.0 0.3
Mother’s age at death 0.9 1.1 3.4 -1.6 0.0 0.6 0.5 -0.2 0.8 -1.0 -1.0 1.4 -1.9 0.9 0.1 -1.3 -0.3 1.3 1.0 -1.4
Financial situation satisfaction 2.0 2.5 8.3 0.4 0.0 -1.1 -1.6 -1.3 -2.1 2.1 0.0 -1.6 2.9 -0.6 1.4 0.2 2.6 -2.4 -1.4 1.0
Tinnitus: Yes, now most or all of the time 0.6 0.8 2.5 0.1 0.0 -0.7 -0.2 -1.6 -0.9 0.7 0.5 -0.6 1.1 -0.2 0.8 0.9 1.2 -1.1 -0.9 1.3
Commuting to job workplace: Public transport 0.7 0.9 2.8 -0.3 0.0 -1.2 -0.6 -1.7 -1.1 0.8 0.9 -1.4 0.2 -0.5 0.0 1.1 0.1 -1.0 -1.3 1.3
Eye problems/disorders: Glaucoma 0.2 0.3 0.8 -0.8 0.0 0.9 0.4 0.8 0.6 0.6 0.1 -0.5 -0.5 0.6 -0.6 0.1 -0.4 -0.0 -0.0 -0.3
Medication: Blood pressure 0.4 0.7 3.1 -1.3 0.0 0.3 -0.1 0.8 -0.3 1.1 -1.8 -0.5 0.3 -0.0 0.4 -1.5 0.6 -0.2 0.3 -1.3
Pain type(s) experienced in last month: Hip pain 0.5 0.7 3.1 0.0 0.0 -1.1 -0.1 -0.6 0.0 0.6 -0.8 -1.8 -0.7 -1.2 0.8 -1.0 -0.0 -0.1 -0.9 -1.1
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.5 -1.1 0.0 0.6 -0.6 0.4 -0.8 0.7 -1.3 0.6 1.9 0.7 0.8 -1.3 0.8 -0.8 0.5 -0.5
High cholesterol (Self-reported) 0.6 1.0 3.8 0.6 0.0 0.2 -1.9 -0.9 -1.2 1.7 0.3 0.0 1.5 1.2 0.8 0.4 1.4 -1.0 0.0 0.8
Medication: Bendroflumethiazide 0.5 0.7 4.5 -2.1 0.0 -0.1 0.2 -0.4 -0.7 1.0 -1.6 -0.9 0.5 0.1 -0.4 -0.9 1.0 -0.8 0.2 -0.3
Medication: Paracetamol 0.2 0.3 1.1 -0.1 0.0 1.1 0.3 0.7 -0.2 0.5 0.6 -0.5 0.1 1.0 -0.4 0.8 -0.3 -0.1 -0.2 0.4
Medication: Lisinopril 0.5 0.7 4.3 -0.4 0.0 -0.1 0.6 0.0 0.2 -0.1 -2.1 0.4 -0.2 -0.2 0.0 -1.8 0.7 -0.0 1.4 -1.1
Medication: Atorvastatin 0.5 0.6 2.3 0.3 0.0 0.3 -0.2 0.9 -0.9 1.1 0.2 -0.6 0.9 -0.1 1.5 0.4 1.1 -1.3 -0.6 0.7
Illnesses of father: High blood pressure 0.3 0.3 2.0 1.4 0.0 -0.4 -1.0 0.4 -0.6 0.6 -0.5 0.2 0.7 -0.3 -0.7 -0.2 0.4 -0.2 0.4 -0.1
Alcohol drinker status: Never 0.2 0.2 1.5 -0.0 0.0 0.0 0.3 0.1 -0.3 0.2 -0.3 -0.2 -0.4 -0.1 1.2 -0.2 0.9 -0.4 0.1 0.5
Ever smoked 0.3 0.5 1.6 1.1 0.0 -0.7 -1.1 -0.5 -0.1 0.4 1.3 -0.2 0.6 -0.6 -0.5 1.1 -0.2 -0.4 -0.8 0.8
Basal metabolic rate 0.6 3.6 9.3 2.8 0.0 -2.0 0.3 -0.3 -1.2 0.6 2.8 -1.2 1.0 -2.6 1.4 3.0 1.3 -1.6 -2.3 3.0
Leg fat percentage (left) 0.7 2.6 15.9 4.0 0.0 -1.0 -0.8 0.4 -1.1 0.5 2.3 -0.5 1.9 -1.3 0.5 2.2 0.7 -1.3 -1.3 2.4
Arm fat-free mass (left) 0.9 4.8 13.0 3.0 0.0 -2.4 -0.2 -0.8 -1.3 0.9 3.3 -1.6 1.3 -2.9 1.4 3.6 1.2 -1.6 -2.7 3.6
Number of operations (self-reported) 1.0 1.5 4.3 -0.9 0.0 0.8 1.1 1.1 1.4 -1.8 -0.9 1.1 -1.2 0.1 -1.9 -0.7 -0.9 2.1 1.6 -0.9
Average weekly beer plus cider intake 1.0 1.4 6.5 1.1 0.0 -0.7 0.6 0.8 -1.5 0.2 1.1 -0.7 0.9 -1.4 2.5 0.9 1.3 -1.6 -1.3 1.4
Irritability 0.3 0.5 1.5 -0.7 0.0 -0.4 0.0 0.4 0.0 -0.2 1.0 -1.2 -0.5 -0.9 -0.4 1.1 -1.2 0.1 -1.2 0.5
Risk taking 0.9 1.3 4.3 1.2 0.0 -2.1 -1.2 -1.5 -0.1 0.0 1.5 -0.7 0.1 -2.0 -0.7 1.3 -0.4 -0.5 -1.7 0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.2 0.7 0.0 0.6 0.3 0.3 -0.3 -0.4 0.3 1.8 1.8 0.5 -1.0 0.7 0.9 -0.0 1.0 1.2
Fractured/broken bones in last 5 years 0.4 0.5 2.2 1.2 0.0 -0.9 -1.0 -1.5 -0.0 0.4 0.4 0.4 1.0 -0.4 -0.9 0.2 -0.1 -0.5 0.4 0.4
Age started oral contraceptive pill 0.8 1.1 3.1 -0.8 0.0 1.2 0.6 1.1 0.9 -1.3 -1.2 1.5 0.5 1.1 -0.1 -1.3 -0.2 1.1 1.8 -0.6
Diastolic blood pressure, automated reading 0.2 0.8 2.6 -1.3 0.0 0.9 1.6 0.6 0.5 -0.6 -0.9 1.2 0.9 0.6 -0.7 -0.8 -0.3 0.5 1.1 -1.0
Ever depressed for a whole week 0.4 0.5 1.9 0.4 0.0 -0.9 -0.6 -1.2 -0.7 1.0 0.0 -1.4 1.1 -0.3 -0.4 -0.1 0.3 -0.9 -0.7 -0.0
Unable to work because of sickness or disability 0.3 0.4 1.3 1.1 0.0 -0.7 0.2 -0.1 -0.4 0.1 0.7 -0.3 0.9 -0.9 -0.0 0.9 0.6 -0.5 0.0 1.1
Commuting to job workplace: Cycle 0.5 0.6 2.6 0.2 0.0 -0.5 -0.2 -1.6 -0.4 -0.3 -1.4 0.2 -0.6 0.1 1.1 -1.4 0.2 0.2 0.2 -1.4
Myopia 1.0 1.4 4.7 -0.3 0.0 1.3 1.7 -0.1 0.8 -2.0 -0.8 2.2 -0.1 1.4 -0.5 -0.9 -0.6 1.6 1.6 -0.8
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.6 0.6 0.0 -0.2 -0.8 -0.7 -0.3 0.1 1.3 0.1 0.2 0.3 0.1 1.0 -0.1 -0.7 -0.6 1.0
Cholesterol lowering medication 0.4 0.6 3.0 0.3 0.0 0.0 -0.6 -0.3 -0.4 0.8 -1.3 0.5 0.9 0.3 0.7 -1.0 1.7 -0.7 1.1 -0.3
Medication: Omeprazole (e.g. Zanprol) 4.4 5.4 11.2 -1.7 0.0 2.8 -0.1 2.2 2.2 -1.7 -2.2 2.7 -1.8 2.8 -3.1 -1.9 -2.3 3.4 2.9 -2.6
Pain experienced in last month 0.4 0.6 4.0 -0.6 0.0 -0.5 -0.2 -2.0 -1.0 0.6 -0.7 0.1 0.5 0.5 -0.1 -0.7 1.1 -1.0 0.5 0.6
Supplements: Calcium 1.0 1.1 4.7 1.4 0.0 0.9 -0.2 1.2 -1.2 1.5 0.4 -0.3 2.2 0.8 0.1 0.8 1.4 -1.0 0.2 1.2
Basal cell carcinoma (self-reported) 0.2 0.3 1.4 -0.1 0.0 0.8 0.3 -0.7 0.1 -0.7 0.2 1.1 0.1 1.2 0.0 0.2 -0.2 0.4 0.4 0.4
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.8 -0.2 0.0 0.9 -0.7 0.8 0.5 0.3 -0.4 0.3 0.0 0.8 -0.3 -0.9 -0.5 0.5 0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 3.8 -0.6 0.0 1.7 0.1 0.7 1.5 -0.2 -0.7 1.1 -1.0 1.9 -1.4 -0.5 -0.5 1.5 1.6 -0.9
Heart disease (siblings) 0.8 0.9 3.5 -1.3 0.0 -1.0 -0.4 -1.4 -0.5 1.2 -0.5 -1.0 0.3 -0.6 1.9 -0.5 1.5 -1.0 -0.6 0.0
Alcohol drinker status: Previous 0.4 0.5 2.1 0.2 0.0 -0.6 -0.2 -0.1 -0.5 0.7 -0.5 -0.9 -0.3 -1.0 1.3 -0.3 1.5 -0.8 -0.5 -0.1
Pack years of smoking 0.1 0.2 0.6 0.5 0.0 -0.2 0.7 0.4 0.4 -0.4 0.7 -0.1 -0.2 -0.5 0.4 0.5 -0.7 -0.0 -0.2 0.5
Impedance of whole body 1.4 6.9 17.9 -2.3 0.0 4.1 0.8 2.5 1.8 -1.5 -3.0 2.3 -1.3 4.2 -2.6 -3.2 -2.2 2.4 3.1 -3.5
Leg fat mass (left) 0.8 3.2 16.5 4.1 0.0 -1.3 -0.5 0.4 -1.0 0.6 2.6 -0.6 1.9 -1.8 0.7 2.7 0.9 -1.4 -1.6 2.8
Arm predicted mass (left) 0.9 4.7 12.6 2.9 0.0 -2.5 -0.2 -1.0 -1.4 0.8 3.3 -1.6 1.1 -2.9 1.6 3.5 1.3 -1.5 -2.7 3.5