Hub : Genes

FRAS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.261 0.0520 2.7e-11 0.032 0.124 0.143 0.151 0.104 7.4e-05 7.8e-15 5.3e-17 5.1e-18 1.3e-12
2 GTEx Artery Aorta 0.267 0.0860 7.5e-04 -0.003 NA 0.007 NA 0.005 5.4e-01 NA 1.3e-01 NA 1.6e-01
3 GTEx Breast Mammary Tissue (Male) 0.219 0.1787 1.7e-01 -0.012 NA -0.012 NA -0.011 7.4e-01 NA 8.0e-01 NA 7.3e-01
4 GTEx Cells Transformed fibroblasts 0.213 0.0640 2.8e-04 0.004 NA 0.011 NA 0.001 1.6e-01 NA 5.0e-02 NA 2.9e-01
5 GTEx Colon Sigmoid 0.187 0.0870 7.3e-03 0.012 NA 0.005 NA 0.002 1.2e-01 NA 2.0e-01 NA 2.8e-01
6 GTEx Heart Atrial Appendage 0.236 0.0690 7.5e-05 0.011 NA 0.048 NA 0.056 1.0e-01 NA 3.2e-03 NA 1.6e-03
7 GTEx Muscle Skeletal 0.113 0.0384 1.3e-05 0.060 NA 0.076 NA 0.075 1.5e-06 NA 6.3e-08 NA 7.8e-08
8 GTEx Nerve Tibial 0.361 0.0691 1.8e-14 0.178 NA 0.283 NA 0.272 1.2e-12 NA 2.8e-20 NA 1.9e-19
9 GTEx Spleen 0.748 0.0730 1.2e-06 -0.010 NA 0.284 NA 0.239 7.4e-01 NA 5.6e-08 NA 8.1e-07
10 GTEx Stomach 0.114 0.0530 5.2e-03 -0.005 NA 0.013 NA 0.007 7.4e-01 NA 7.7e-02 NA 1.5e-01
11 ROSMAP Brain Pre-frontal Cortex 0.246 0.0475 1.2e-14 0.029 0.125 0.126 0.135 0.110 1.1e-04 9.2e-16 7.3e-16 5.1e-17 5.0e-14
12 TCGA Brain Lower Grade Glioma 0.108 0.0348 1.9e-06 0.052 0.054 0.064 NA 0.046 1.5e-06 9.6e-07 8.7e-08 NA 5.5e-06
13 TCGA Ovarian Serous Cystadenocarcinoma 0.092 0.0380 3.8e-04 0.042 0.036 0.029 NA 0.045 7.4e-04 1.8e-03 4.2e-03 NA 5.1e-04
14 TCGA Prostate Adenocarcinoma 0.037 0.0179 7.8e-03 0.017 0.016 0.005 NA 0.028 6.1e-03 7.8e-03 9.4e-02 NA 5.2e-04
15 TCGA Thyroid Carcinoma 0.132 0.0580 1.6e-03 0.051 0.024 0.034 NA 0.037 9.5e-06 2.1e-03 2.5e-04 NA 1.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.3 0.5 1.5 -0.4 0.7 0.9 0.3 0.8 -1.1 -0.5 0.8 -0.4 -0.7 -0.3 -0.6 -0.6 0.4 -1.2
Bipolar Disorder or Schizophrenia 0.4 1.0 3.3 1.8 0.5 0.9 -0.4 0.8 -0.7 -0.1 0.0 -0.1 -1.4 1.0 0.7 -1.7 -0.9 -1.4
Depressed Affect (Nagel 2018) 1.2 2.4 10.6 0.2 1.3 1.4 -0.1 3.3 0.4 -2.2 2.5 0.3 0.1 2.2 -0.8 2.2 0.6 -0.3
Depression (Nagel 2018) 0.3 0.5 2.3 -0.3 0.6 1.5 0.6 0.8 -0.3 -1.0 -0.1 0.2 0.2 -0.3 0.1 0.5 0.7 -1.4
Intelligence (Savage-Jansen 2018) 0.4 1.2 4.8 0.0 0.1 0.8 1.2 0.3 0.1 0.3 -0.5 -0.5 2.1 -0.5 -0.2 -1.4 1.9 2.2
Neuroticism (Nagel 2018) 0.7 1.7 5.8 0.4 1.2 1.8 -0.8 2.4 0.2 -1.5 2.1 0.9 -0.1 1.9 -0.4 1.6 0.4 -0.1
Schizophrenia (2018) 0.7 1.4 7.0 2.6 0.3 0.4 -0.9 0.4 -0.0 0.4 -0.7 0.3 -1.2 1.6 1.5 -1.7 -1.5 -0.8
Schizophrenia vs Biploar Disorder 0.8 1.1 4.7 1.4 -0.0 -2.2 -0.8 -0.2 -0.3 1.1 -0.7 1.0 -0.9 1.2 0.8 -0.6 -1.6 1.0
Worry (Nagel 2018) 0.3 0.6 3.0 1.5 0.9 0.9 -0.3 0.8 -0.4 -0.3 0.4 0.6 -0.9 1.7 0.2 0.3 -0.1 -0.6
Alzheimer’s Disease (in mother) 1.0 1.2 3.1 1.8 -1.2 0.9 -0.9 -0.1 1.5 0.3 -0.7 0.2 -1.4 1.6 0.4 0.1 -1.1 1.7
Alzheimer’s Disease (in father) 0.8 0.9 2.8 0.8 1.1 -1.7 1.2 0.5 1.0 0.1 0.6 -0.3 -0.3 0.4 -1.4 1.0 -0.4 1.4
Alzheimer’s Disease (including proxy) 0.4 0.7 2.2 1.3 -0.4 0.0 -0.4 0.5 0.9 -0.1 0.2 0.3 -1.2 1.1 -0.4 0.1 -1.5 1.2
Crohns Disease (2017) 1.1 2.4 9.9 -0.1 0.8 -0.4 -1.8 1.0 -0.2 -2.0 3.1 0.8 1.5 0.8 -1.7 2.3 1.2 -2.1
Irritable Bowel Disease (IBD) 0.7 1.6 5.0 0.0 0.3 -1.5 -0.5 1.4 -0.6 -1.0 2.2 0.9 1.8 1.6 -0.9 1.7 0.5 -1.7
Ulcerative Colitis (UC) 0.3 0.6 2.1 0.1 -0.2 -1.3 0.3 1.1 -0.8 -0.3 0.7 0.5 1.4 1.0 -0.2 0.4 -0.3 -0.9
Major Depression (MDD) 0.5 0.6 1.3 -0.8 0.6 -0.2 -0.6 0.4 0.9 0.2 1.1 -1.1 0.1 -1.0 1.0 -1.1 0.8 0.1
Reaction Time 0.4 0.7 1.8 0.9 -1.3 -0.1 -1.1 -1.2 0.6 1.0 0.1 0.8 -0.3 0.5 1.1 -1.1 -0.3 0.5
Verbal and Numeric Reasoning (VNR) 0.5 1.1 6.4 -1.0 -0.4 -0.0 0.9 1.4 -0.7 -0.4 0.3 -0.5 2.5 -0.5 -0.6 -0.5 1.9 0.9
Breast Cancer 0.4 0.9 3.4 1.2 0.9 0.8 -0.8 1.5 0.7 -1.8 0.6 0.6 0.2 1.0 -0.7 0.7 -0.6 0.8
Ovarian Cancer 0.9 1.2 3.7 -1.2 -0.6 1.2 1.4 -0.8 0.1 -1.0 1.4 -1.9 0.1 -0.1 -1.8 1.1 0.3 0.8
Prostate Cancer 0.8 1.1 7.1 -1.2 0.4 -0.8 0.2 -2.7 0.4 -0.3 -0.0 -0.8 -0.5 -1.7 -1.2 1.3 -0.6 0.5
Age at First Birth 0.4 0.7 2.2 -0.4 0.5 -0.6 0.7 0.4 1.5 -0.6 0.8 0.8 0.8 0.9 0.2 0.3 0.9 1.5
Bipolar Disorder (2011) 0.8 0.8 3.4 -1.4 0.8 0.6 0.2 1.2 -1.4 -0.3 0.3 -0.6 -0.7 -1.0 -0.4 -0.0 -0.1 -1.8
Body Mass Index (BMI) (2010) 0.1 0.2 1.1 -0.2 0.3 1.1 -0.1 -0.3 -0.6 0.4 -0.1 0.4 -0.3 -0.1 0.1 0.5 0.1 -0.7
Coronary Artery Disease (CAD) 0.5 0.6 2.5 1.6 -0.9 -0.3 0.8 -0.5 -0.7 0.2 -0.1 -0.9 0.3 0.1 -0.0 -1.1 1.1 -0.5
Crohns Disease (2012) 0.6 1.0 5.1 0.1 1.2 0.1 -1.0 0.0 1.6 -0.0 1.4 1.5 0.4 0.3 -0.9 2.3 0.3 -0.3
Mean Putamen Volume 1.2 1.4 5.6 0.8 -2.1 2.4 -0.8 -1.1 1.5 0.8 -0.8 -1.0 1.0 -1.1 0.1 -0.1 0.5 1.4
Fasting Glucose 0.8 1.0 3.5 -0.3 -0.4 -0.7 0.7 -0.5 1.4 1.7 -1.5 0.7 -0.4 -1.9 0.4 -0.6 -1.0 0.3
HbA1C 0.4 0.4 2.1 0.4 1.4 1.2 0.7 0.7 -0.3 0.2 -0.4 -0.8 0.6 0.6 -0.2 -0.5 0.2 0.2
HDL Cholesterol 0.2 0.4 1.7 -0.1 0.7 0.6 0.7 -0.6 0.7 -0.3 -0.0 -0.6 0.7 0.6 0.1 -0.4 0.6 1.3
LDL Cholesterol 1.8 2.8 14.4 -0.1 -1.3 0.9 1.5 -3.0 -1.1 1.2 -3.8 0.1 -0.9 -2.8 0.3 -1.1 -0.6 -0.9
Lupus 0.5 0.8 3.0 -0.5 0.4 0.8 -1.0 -0.1 -1.7 0.3 -1.0 0.5 -0.0 -1.0 -0.0 -0.7 1.1 -1.7
Neuroticism (2016) 0.6 0.8 3.4 -0.6 -1.8 0.1 -1.2 0.7 -0.7 1.3 -0.2 0.4 1.3 -1.5 -0.2 0.4 0.3 -0.6
Primary Biliary Cirrhosis 0.7 1.0 2.8 1.7 -0.8 1.6 -1.5 0.0 1.3 0.9 -0.7 0.7 -0.1 -0.2 0.3 -0.7 -0.1 1.7
Rheumatoid Arthritis 0.6 0.9 3.6 0.1 0.5 0.1 -0.0 -0.8 1.2 -1.8 0.2 -1.1 0.8 -0.3 -1.9 0.4 -0.2 1.4
Schizophrenia (2014) 0.8 1.8 8.5 2.9 0.0 1.1 -1.1 0.2 0.3 0.6 -0.5 1.6 -1.5 1.7 1.1 -1.2 -2.1 -0.5
Triglycerides 0.6 1.0 3.9 2.0 0.2 -0.7 -0.3 -0.8 0.9 2.0 -1.0 1.0 -1.4 -0.1 0.8 -0.5 -0.2 -0.0
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.3 -0.0 0.5 0.4 1.4 -0.7 1.1 -1.0 0.0 -1.5 -0.3 -1.1 -1.3 0.7 0.2 0.6
Ulcerative Colitis 0.6 0.8 5.1 0.7 -0.0 -0.1 0.1 0.7 0.3 0.2 -0.5 2.2 0.2 0.8 -0.5 1.5 -1.5 -0.4
Blood Eosinophil Count 0.1 1.1 4.9 0.3 -0.3 1.3 0.5 0.2 -1.0 -0.6 -0.6 0.7 2.2 -0.1 -1.1 0.9 1.6 -1.7
Blood Platelet Count 0.1 1.7 6.7 1.1 -0.2 0.2 -1.0 -0.5 2.3 -1.5 0.2 -1.7 -0.3 1.8 1.3 0.3 -2.6 0.0
Blood Red Count 0.7 7.0 16.5 1.4 -2.5 0.3 2.6 -4.1 2.5 3.9 -2.9 -2.5 -1.0 -2.6 2.7 -4.0 -0.7 2.5
Blood White Count 0.4 2.8 11.6 2.3 0.7 0.2 1.3 -3.4 1.5 -1.3 -0.3 -3.1 1.6 0.8 0.2 -1.2 1.8 0.8
Heel T-Score 0.4 3.0 12.0 -0.4 0.3 3.5 -0.3 1.1 -0.9 -1.6 1.6 1.3 3.2 -0.1 -2.6 1.1 2.1 -0.7
BMI 0.7 4.3 16.9 3.3 0.7 0.7 0.0 -0.9 -1.1 0.5 -1.6 -1.4 -4.1 2.5 3.2 -1.8 -2.0 -2.3
Height 0.1 2.5 7.5 1.8 -2.1 -2.1 -1.3 -0.0 1.3 1.9 -0.8 -0.1 -0.6 0.6 2.7 -2.5 -0.5 1.6
Waist Hip Ratio (WHR) 0.5 2.2 6.8 1.7 1.8 0.5 -0.8 -0.2 0.4 -0.6 -2.4 -1.3 -2.6 0.3 1.4 -0.4 -2.6 -1.6
Systolic Blood Pressure 0.6 2.9 8.2 0.5 0.8 -0.6 1.9 -2.5 2.7 -1.7 0.1 -2.6 -0.0 -1.9 -1.8 0.3 -0.5 2.9
Smoking Status 0.4 1.0 4.4 -0.8 1.4 0.3 -0.6 0.2 -0.9 -2.1 0.9 -1.6 -0.5 0.3 0.1 -0.7 0.8 -1.1
Allergy or Eczema 0.4 1.1 4.2 -1.8 0.3 2.1 0.6 0.2 0.1 -0.6 0.4 -0.4 0.3 -0.9 -1.1 1.5 0.5 -1.8
Cardiovascular Disease 0.2 0.7 2.9 0.9 0.6 1.7 0.1 -0.4 1.0 -1.2 0.8 -1.0 -0.2 1.2 -0.2 0.5 0.4 0.5
Hypothyroidism (self reported) 0.4 0.9 4.3 1.9 0.2 1.3 -0.1 0.4 1.1 0.3 0.3 0.7 -0.6 2.1 1.0 0.0 -0.2 0.8
Respiratory disease 0.6 1.3 4.0 0.1 -0.2 1.7 -1.9 0.8 2.0 -1.1 2.0 0.7 0.8 0.4 0.9 -0.5 -0.2 -0.3
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.8 1.2 1.6 -0.2 -0.5 -0.1 1.7 -0.3 -0.0 0.5 -0.3 1.4 -0.3 1.3 -0.4 0.3
Lung FEV1/FVC ratio 1.6 7.9 44.9 -0.0 -0.3 0.9 3.6 -3.8 -4.2 1.3 -1.6 -2.8 2.5 -1.6 0.8 -2.5 6.7 -1.3
Lung FVC 0.2 1.2 7.6 -1.2 1.0 -2.8 -0.3 0.5 -0.1 -1.2 -0.1 -0.4 -0.4 -1.8 -0.3 -0.5 1.4 0.8
Neuroticism 0.5 1.3 5.5 0.4 0.9 1.3 0.3 2.3 -0.9 -1.5 0.7 0.5 0.0 1.6 -0.8 1.7 0.5 -1.1
Chronotype (morning person) 0.4 1.0 3.3 -0.2 -0.9 0.1 -0.4 1.8 -0.6 -0.9 0.5 1.8 1.0 -0.4 -0.5 1.7 0.3 -1.0
Hair Pigment 2.0 57.7 237.2 -4.5 0.9 4.4 -7.0 10.5 0.8 -13.1 15.4 -1.8 7.0 4.3 -7.4 9.5 6.1 -1.8
Tanning 0.1 0.6 1.9 -0.1 0.8 -1.4 1.2 -0.0 1.0 -0.2 -0.6 -0.8 -1.4 -0.8 -0.2 -0.4 -0.3 -0.6
Hand grip strength (left) 0.2 0.5 2.0 -0.2 1.0 -1.4 -0.2 -0.8 0.0 -0.5 1.0 -1.0 0.1 -0.5 -1.2 -0.2 0.4 0.3
Number of treatments/medications taken 0.4 0.7 2.2 1.4 -0.5 0.7 -0.5 -0.2 1.5 -1.3 0.2 -0.6 0.3 1.2 0.9 0.1 -0.4 0.0
Average weekly spirits intake 1.2 1.5 7.1 1.0 0.0 1.2 0.3 -1.6 -0.9 -0.2 -2.7 -0.4 -1.3 -0.6 0.4 -0.6 -1.8 -1.8
Sensitivity / hurt feelings 0.7 1.1 4.8 0.7 0.3 1.4 -2.2 1.1 -0.3 -1.0 0.6 -0.1 -1.1 1.2 0.8 0.7 -0.1 -1.7
Frequency of depressed mood in last 2 weeks 0.5 0.7 5.2 -0.1 -0.7 2.3 0.9 0.5 -1.0 -0.2 -0.6 1.1 0.5 -0.4 0.8 0.0 0.5 -0.6
Hearing difficulty/problems: Yes 0.8 1.3 5.6 -0.8 0.2 0.0 1.3 2.4 -0.9 -1.9 1.1 0.5 -0.1 1.5 -0.1 0.8 -0.8 -1.4
Relative age of first facial hair 1.6 3.2 7.9 -0.3 -0.8 -2.3 2.3 -2.4 -0.2 2.6 -2.2 -0.2 -2.0 -2.8 0.2 -1.5 -2.4 0.4
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 7.7 1.7 0.0 -1.0 0.1 2.0 -0.1 -0.5 1.0 -0.2 -0.5 2.8 0.3 0.7 0.1 0.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.3 -1.4 0.8 -0.2 0.7 1.0 0.7 -1.8 0.6 -1.2 0.5 -0.3 0.3 1.5 -0.1 -1.0
Ever had hysterectomy (womb removed) 1.0 1.2 4.3 0.8 -1.8 -2.1 0.5 -0.3 0.4 0.5 -0.7 -1.3 -0.2 -0.2 1.1 -1.3 -1.8 0.4
Systolic blood pressure, automated reading 0.8 2.2 9.9 0.3 0.3 -0.7 1.4 -2.1 2.1 -1.2 -1.1 -3.1 -1.4 -1.9 -0.5 -0.4 -1.4 1.4
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.2 0.5 0.8 -1.6 1.5 -0.9 0.3 2.1 -1.7 1.3 -0.0 0.9 -0.2 0.5 -1.7 0.7
Angina 0.9 1.2 3.3 1.2 -1.8 1.1 0.2 0.0 1.1 0.1 0.8 -0.3 1.8 0.1 1.4 -1.4 1.2 1.0
Medication for hormone replacement therapy 1.8 2.1 8.7 -0.5 3.0 -0.9 1.3 -0.7 -0.6 -1.8 0.4 -2.1 -0.3 -0.3 -1.7 2.0 0.1 -1.9
Vitamin and mineral supplements 1.6 2.2 9.2 -0.3 1.5 -0.8 -1.0 -0.3 -0.8 -1.1 2.3 0.2 3.0 0.2 -2.5 1.1 2.3 -0.2
Supplements: Zinc 0.5 0.5 2.1 -0.0 -0.8 0.8 -0.6 1.5 0.2 -0.1 0.0 -0.3 -1.4 -0.5 0.5 -0.1 -1.1 0.6
Medication: Co-codamol 0.8 0.9 2.7 0.4 -0.8 0.7 -0.4 -1.1 -0.7 1.5 -1.1 0.9 1.0 0.5 1.1 -0.8 -0.2 -1.6
Medication: Metformin 0.9 1.3 6.3 1.0 1.2 0.7 -0.0 -0.8 0.7 0.1 -0.3 2.0 0.0 1.8 -1.2 2.5 -0.3 0.1
Diabetes (father) 1.3 1.6 6.6 -0.1 1.2 -0.5 0.6 0.5 -0.6 0.7 -0.8 2.6 -2.2 0.1 -0.2 1.3 -1.1 -2.4
Diabetes (mother) 1.5 1.9 8.9 3.0 1.2 -0.7 0.2 0.1 1.5 0.7 -0.6 -0.8 -1.7 1.5 2.4 -0.7 -1.5 -0.3
Severe depression (siblings) 1.3 1.5 5.9 -0.1 1.4 0.2 0.8 2.2 0.3 -1.7 0.6 2.4 -0.9 0.4 0.4 1.3 -0.3 -1.5
Pack years adult smoking proportion 0.4 0.7 3.3 0.5 1.8 1.2 0.6 0.2 0.4 -1.5 0.1 -0.4 -0.6 0.8 -0.3 0.0 0.8 0.7
Impedance of leg (right) 0.6 2.8 12.2 -3.5 -1.7 0.6 -0.3 -0.0 -1.6 2.7 0.1 -0.0 1.5 -3.3 0.6 -1.0 0.9 -1.3
Leg fat-free mass (left) 0.5 2.8 13.1 3.6 1.0 -1.8 -1.1 0.0 0.5 0.7 -0.9 0.6 -2.9 3.1 1.6 -0.4 -0.7 -0.3
Trunk fat percentage 0.9 3.7 16.3 0.6 -0.5 1.0 -2.0 0.0 -3.4 2.0 -1.2 0.0 -1.9 0.0 2.9 -2.0 -0.7 -4.0
Hand grip strength (right) 0.2 0.6 5.5 0.1 0.8 -2.3 -0.2 -0.6 -0.2 -0.0 -0.0 -0.7 -0.8 -0.4 -0.8 -0.7 0.1 0.3
Townsend deprivation index at recruitment 1.0 1.3 5.7 2.0 -1.0 0.1 -0.8 1.4 0.5 -0.7 1.3 1.3 0.4 2.4 0.2 1.5 -0.1 0.5
Current tobacco smoking 0.4 0.7 2.1 0.8 1.5 -0.1 -0.3 0.8 0.6 -1.3 0.8 -0.6 -1.4 1.2 0.5 -0.3 0.3 0.5
Average weekly fortified wine intake 0.7 0.8 3.2 1.3 -0.6 -0.7 -0.0 0.0 1.1 0.1 -1.8 0.3 -0.7 -0.5 0.7 -0.1 -1.1 1.5
Maternal smoking around birth 1.0 1.4 4.0 -1.1 -1.6 2.0 -0.2 1.6 -0.4 1.1 -0.6 -0.1 -0.6 -1.7 1.4 -0.8 0.8 -1.5
Fed-up feelings 0.5 0.8 2.6 1.6 -0.3 0.8 0.5 1.0 -0.6 -1.1 0.2 -0.5 -1.2 1.3 -0.2 1.5 -0.7 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.6 -0.2 -0.8 1.4 -0.2 0.7 -1.2 0.1 0.1 1.1 0.1 0.9 0.5 -0.1 0.1 -1.6
Relative age voice broke 1.3 1.9 6.8 -1.5 1.3 -2.0 1.4 -1.4 -1.1 0.2 -0.6 -1.1 -1.3 -2.6 -2.4 0.6 -0.1 -0.6
Taking other prescription medications 0.5 0.8 4.0 0.1 0.3 -0.5 -1.2 2.0 0.4 -1.4 0.7 0.3 0.1 0.5 0.7 -0.1 -1.2 -0.7
Age when periods started (menarche) 1.4 3.3 9.2 1.2 -1.9 -0.9 1.7 -2.2 0.9 3.0 -2.4 -0.1 -1.6 -0.7 1.5 -2.2 -1.6 2.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.9 -0.7 -1.7 0.3 0.6 0.5 -1.7 0.0 -0.4 -0.2 1.3 -1.6 -0.8 -0.6 0.1 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 6.2 -0.7 -0.9 2.3 0.0 -0.6 0.0 -0.5 1.4 -0.4 2.5 -0.2 -1.6 1.6 0.7 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 2.9 1.0 0.2 -0.1 -1.1 0.5 -0.3 0.5 -0.3 0.3 -1.7 0.6 -0.3 -0.3 -0.5 -0.0
Qualifications: CSEs or equivalent 1.4 1.9 9.9 1.2 1.7 -1.0 -3.1 1.2 0.6 -0.0 2.1 -0.0 -0.7 2.5 0.1 0.4 -0.5 -0.1
Serious illness, injury or assault to yourself 1.7 2.1 6.2 1.9 -1.7 0.7 0.6 -1.9 1.1 2.5 -1.1 -0.9 -1.1 0.5 2.1 -1.5 0.2 1.6
High blood pressure 0.1 0.4 1.5 0.3 -0.8 1.0 1.2 -0.6 -0.4 0.0 0.2 -0.8 0.3 0.4 0.5 -0.1 -0.1 -0.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 6.1 -1.3 -0.3 2.5 0.1 0.0 0.0 -0.7 0.6 -0.5 1.1 -0.8 -1.4 1.1 1.3 -0.7
Multivitamins +/- minerals 0.8 1.0 3.4 0.1 -1.3 0.6 1.3 0.3 0.2 0.7 -1.2 -1.1 -1.8 -0.2 1.6 -1.2 -1.1 -0.0
Stomach or abdominal pain in last month 0.5 0.6 2.7 0.1 0.2 0.4 -1.4 0.2 -0.9 0.2 -0.1 0.6 -1.7 -0.5 0.0 0.4 0.0 -1.5
Supplements: Glucosamine 0.3 0.4 1.4 -0.2 -0.8 1.1 0.2 0.6 0.2 0.7 -0.7 -0.1 0.4 -0.6 1.2 -0.5 0.1 0.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.7 1.6 1.3 0.0 0.6 -1.4 1.0 0.2 -1.2 -0.9 -1.1 0.6 0.2 0.2 -1.5 1.3
Medication: Atenolol 0.5 0.6 2.5 -0.3 0.9 -1.3 1.4 -1.1 -1.6 -0.2 0.1 -0.0 -0.5 0.2 0.6 -0.3 -0.5 -0.4
Medication: Levothyroxine sodium 0.3 0.6 3.6 0.6 0.0 -0.5 -0.6 -0.2 0.7 0.7 -0.3 1.9 0.2 0.4 1.4 -0.6 -0.5 -0.5
Sitting height 0.2 1.6 5.8 -0.6 -0.8 -2.2 -1.5 -0.2 0.5 1.9 1.1 0.8 1.4 0.1 1.5 -0.7 2.4 -0.4
Chronic bronchitis/emphysema (father) 0.8 0.9 3.8 0.1 -0.2 0.3 1.2 0.7 0.1 -2.0 0.8 -1.2 1.4 0.4 -0.7 1.2 1.0 -0.5
High blood pressure (mother) 0.3 0.5 2.1 0.1 1.2 -0.4 -0.6 0.6 -0.4 -1.0 -0.2 0.5 0.7 0.2 -0.2 0.5 -0.1 -1.5
Body mass index (BMI) 0.7 2.9 8.9 3.0 1.2 0.7 -0.7 -0.5 -1.0 0.3 -1.4 0.1 -2.8 2.5 2.5 -0.9 -1.6 -2.2
Impedance of leg (left) 0.7 3.2 17.5 -4.2 -1.6 0.8 -0.5 0.3 -1.8 2.2 0.4 0.4 1.8 -3.5 0.6 -0.8 0.8 -1.4
Leg predicted mass (left) 0.5 2.8 13.4 3.7 1.0 -1.7 -1.1 -0.0 0.6 0.7 -0.8 0.6 -2.8 3.1 1.6 -0.4 -0.7 -0.1
Trunk fat mass 0.8 3.6 11.3 1.7 -0.3 0.6 -1.9 -0.1 -2.4 2.1 -1.5 0.2 -2.6 1.0 3.4 -1.9 -1.0 -3.3
Waist circumference 0.7 2.6 7.5 2.7 0.5 1.0 -1.1 -0.1 -0.7 0.3 -1.6 -0.4 -2.7 1.8 2.6 -1.2 -1.6 -2.1
Number of incorrect matches in round 0.4 0.6 2.2 0.7 0.3 -0.8 0.4 0.3 1.2 -1.5 0.4 1.3 1.2 0.7 0.4 0.1 -0.8 0.5
Past tobacco smoking 0.7 1.4 7.5 2.7 -0.8 -1.4 0.1 -0.7 1.3 1.7 -0.5 0.1 0.5 1.1 1.2 -1.0 0.2 1.0
Alcohol usually taken with meals 1.1 1.8 6.7 -0.9 -1.6 -1.0 1.7 -0.9 -1.6 1.0 -0.8 -1.9 0.6 -1.9 0.9 -2.6 0.4 0.4
Nervous feelings 0.2 0.4 1.3 1.1 0.0 -0.1 -0.6 0.1 0.5 -0.6 0.7 -0.0 -0.2 0.3 -1.1 0.8 0.3 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.0 0.4 -1.1 0.1 -0.7 1.4 -0.6 0.2 0.3 0.5 -1.1 0.7 -0.6 0.7 -1.4 0.5
Hearing difficulty/problems with background noise 1.0 1.6 7.4 1.1 -0.2 0.7 -1.0 1.9 1.1 -0.3 0.4 2.7 0.0 2.1 1.0 0.7 -1.2 0.6
Hair/balding pattern: Pattern 2 0.6 0.8 3.0 -1.1 1.6 -1.0 0.6 0.2 0.3 -0.8 0.4 0.5 -0.1 0.4 -1.7 1.2 0.2 -1.0
Had menopause 1.0 1.2 3.1 0.5 -0.3 -0.6 1.4 -0.8 0.7 0.9 -1.8 -1.7 0.6 -1.2 1.4 -1.6 -0.7 1.1
Had other major operations 0.5 0.6 1.8 0.1 0.9 -0.6 0.7 0.7 -0.6 0.8 -0.8 1.3 -0.4 0.5 -0.2 1.4 -1.0 -0.5
Forced vital capacity (FVC) 0.4 1.5 6.4 -1.8 -0.4 -2.5 -1.2 0.6 -0.2 0.4 0.1 -0.1 0.0 -2.1 0.6 -1.7 1.6 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 8.2 0.1 0.0 1.9 0.2 -0.8 0.8 -0.6 2.2 -0.8 2.9 0.4 -1.4 1.4 0.9 1.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.6 0.1 1.6 1.2 -0.8 1.5 -0.6 0.3 -0.0 1.4 -0.6 0.1 1.5 -0.7 -0.2 -0.4
Qualifications: None of the above 0.6 1.3 4.2 -1.2 0.2 -1.1 0.1 1.7 -0.9 -2.0 1.8 0.8 -0.1 0.9 0.7 0.4 -0.2 -2.0
Financial difficulties in last 2 years 0.7 0.9 5.8 0.8 0.1 0.3 0.3 -0.3 -0.5 0.1 -0.8 1.1 -2.4 1.1 0.3 0.8 -1.7 -0.4
Mouth/teeth dental problems 0.6 0.9 4.5 0.6 -1.1 -0.7 1.0 -0.3 0.6 1.4 -1.1 0.8 -1.0 0.5 -0.4 -0.4 -0.7 2.1
Heart attack 0.7 0.9 3.1 0.8 -0.5 0.2 -0.4 -0.0 -0.6 -0.4 1.5 0.1 -0.0 1.4 1.5 -1.8 1.5 0.1
Allergy 0.4 1.0 5.5 0.5 0.3 -2.4 0.5 0.3 -1.1 1.0 -0.8 -0.2 -2.0 0.6 0.8 -0.5 -0.9 -0.2
Pain all over the body in last month 1.5 1.6 4.8 -0.5 -0.1 1.7 0.3 -2.1 2.2 0.6 -1.7 0.8 -0.7 -1.5 1.5 0.3 -1.1 0.9
Diabetes (self-reported) 0.5 0.8 3.1 1.0 1.3 0.5 -0.5 -0.4 0.8 -1.0 -0.3 1.0 0.4 1.4 -1.2 1.7 -0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 3.1 -0.9 -0.2 1.8 0.7 0.2 1.0 0.1 0.4 0.7 0.7 -0.1 0.4 0.8 -0.3 -1.0
Medication: Ramipril 0.3 0.4 1.5 -0.2 0.3 -0.7 0.3 0.6 -0.7 0.4 0.4 1.2 -0.1 0.7 -0.1 0.7 -0.7 -1.1
Medication: Simvastatin 0.4 0.5 1.6 0.9 0.2 1.2 0.3 -0.8 0.8 -0.8 0.6 0.4 1.1 1.3 -0.6 0.3 0.1 0.4
Fluid intelligence score 0.5 1.0 3.6 -0.8 0.7 -0.1 1.6 0.8 -0.2 -0.8 -0.3 -0.3 1.9 -0.7 -1.1 0.5 1.1 1.6
Illnesses of siblings 0.2 0.2 1.2 0.5 0.0 0.5 -0.7 -0.6 -0.0 0.6 -0.0 -0.3 0.3 0.1 0.2 -1.1 0.2 0.5
Neuroticism score 0.4 0.8 3.2 1.4 0.2 1.1 -0.2 1.8 -0.3 -1.2 0.6 0.1 -1.1 1.4 -0.1 0.9 -0.4 -0.4
Weight 0.5 2.6 8.9 2.6 0.5 -0.4 -1.1 -0.3 -0.6 1.3 -1.4 0.6 -2.7 2.2 3.0 -1.1 -1.2 -1.7
Impedance of arm (right) 0.9 4.1 13.2 -3.4 -1.8 0.7 -1.8 1.8 -3.6 0.7 0.7 0.3 2.1 -3.5 -1.0 -1.1 1.7 -2.0
Arm fat percentage (right) 0.8 3.2 12.6 1.7 0.7 1.4 -2.0 0.2 -2.8 0.6 -1.2 0.3 -2.5 0.9 2.4 -1.3 -1.1 -3.5
Trunk fat-free mass 0.5 3.0 10.9 3.3 1.1 -1.8 -0.1 -0.4 2.1 0.8 -1.0 0.8 -3.0 2.9 1.9 -0.0 -1.3 0.9
Hip circumference 0.4 1.9 6.2 2.3 0.1 0.9 -1.4 0.3 -0.7 1.3 -0.5 0.9 -1.9 2.1 2.5 -0.8 -0.5 -1.5
Time employed in main current job 0.7 0.9 2.4 1.2 -0.4 0.1 -1.5 0.2 0.5 -1.3 1.4 -1.4 0.6 1.3 -0.3 0.4 0.7 -0.6
Alcohol intake versus 10 years previously 0.4 0.7 2.0 -0.7 0.1 -0.8 -1.2 0.8 -0.8 0.5 0.8 0.9 -0.8 1.4 0.2 1.1 0.4 -0.6
Father’s age at death 0.7 1.0 3.7 0.5 -1.3 0.4 -0.0 -0.0 0.2 1.9 -1.1 1.1 -0.5 -1.3 0.8 -1.6 -0.6 0.8
Worrier / anxious feelings 0.4 0.7 2.0 1.4 -0.5 1.4 -0.6 0.4 1.0 0.2 0.7 -0.4 -1.3 0.8 0.5 0.6 -0.8 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 4.3 0.9 -1.3 1.7 -0.5 0.2 -1.1 0.7 0.5 0.8 2.1 -0.1 0.6 -0.3 1.2 0.0
Falls in the last year 0.9 1.3 6.0 1.7 0.6 2.5 0.6 0.5 -0.2 -1.1 -1.3 0.4 -1.0 1.6 1.6 -0.3 0.1 -0.5
Hair/balding pattern: Pattern 3 0.6 0.9 2.8 1.1 -1.0 -0.1 0.2 0.6 1.7 0.6 0.3 0.2 -0.2 1.5 0.4 1.4 -1.3 0.9
Number of live births 0.6 0.9 3.0 0.7 -0.2 0.1 -0.2 -1.2 -0.3 1.7 -1.7 -0.2 -1.1 -0.9 0.9 -0.7 -1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 11.7 -2.0 -0.3 -2.1 -0.3 -0.1 -1.2 0.3 0.5 -1.1 0.7 -2.1 0.6 -2.0 3.4 0.3
Pulse rate 0.3 0.6 2.6 1.6 0.6 0.3 -0.3 0.2 0.1 1.0 -1.6 0.7 -0.9 0.2 0.4 -0.3 0.1 -0.5
Happiness 1.6 1.9 5.3 1.9 2.3 -1.1 -1.8 2.0 0.4 -0.6 0.2 1.8 -1.2 1.9 0.4 0.1 -1.4 0.0
Noisy workplace 0.5 0.6 2.4 1.0 0.9 0.2 0.7 -0.1 0.3 0.1 -0.2 -1.5 -0.1 0.6 1.1 0.1 1.3 -1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.4 6.4 2.5 -0.3 -0.6 1.1 -0.6 0.9 -0.0 -0.6 -1.7 -0.7 1.8 0.4 -1.9 -0.3 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.2 0.6 -1.8 -1.5 -0.3 1.3 0.6 1.0 -1.1 0.7 -0.7 -0.4 1.6 -1.3 -1.7 1.6
Mouth/teeth dental problems: Dentures 0.4 0.7 3.2 0.4 1.1 0.2 -0.2 0.6 0.1 -1.5 0.2 0.2 1.0 0.3 0.5 1.1 -0.4 -1.8
Asthma 0.5 1.0 4.8 -0.2 0.7 0.9 -1.3 0.5 1.1 -2.2 2.1 0.3 0.7 0.4 -0.2 0.3 0.1 0.0
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 6.4 0.7 1.1 2.5 -1.4 1.7 0.9 -2.3 1.7 0.5 1.2 2.2 -0.4 0.8 1.5 -0.2
Medication: Cholesterol lowering 0.4 0.6 1.7 1.3 -0.2 1.1 -0.4 0.4 1.0 -0.1 0.6 0.6 0.4 1.3 -0.5 0.4 -0.2 1.3
Depression (self-reported) 1.0 1.3 7.4 0.7 -0.0 -1.1 -0.1 0.6 -1.6 -0.6 -2.7 0.0 -1.5 -1.2 0.1 -0.9 -1.1 -0.8
Medication: Lansoprazole 1.5 1.8 5.6 2.4 -0.4 -1.6 -0.4 0.7 0.8 0.7 -0.9 -0.1 -2.3 1.6 1.7 -0.2 -2.2 0.2
Prospective memory result 0.7 0.9 2.8 1.4 -0.6 0.4 -1.5 0.2 -1.5 0.3 -0.2 0.5 0.3 1.6 0.2 -0.3 0.5 -1.7
Lung cancer (father) 1.0 1.2 5.3 1.1 1.0 1.4 -0.0 -0.7 -0.0 -0.3 0.1 0.2 0.5 2.2 -1.4 2.3 -0.4 -0.8
Illnesses of mother 0.5 0.7 2.6 -1.2 -0.8 0.8 1.1 -0.7 -0.5 -0.5 0.8 0.0 0.7 -0.9 -1.6 0.5 0.4 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 5.6 -0.5 0.9 -1.6 -0.7 1.0 -0.7 -0.0 0.6 -0.5 0.5 -0.5 0.6 -0.6 2.4 0.3
Pulse wave Arterial Stiffness index 1.3 1.5 6.0 0.6 -2.1 -1.2 0.8 -1.1 -0.1 0.0 -0.5 -2.2 -0.2 -0.6 -1.1 -1.2 -0.7 2.5
Impedance of arm (left) 0.8 3.9 15.1 -3.3 -1.5 0.3 -1.3 0.8 -3.4 0.9 0.4 -0.5 2.1 -3.9 -1.0 -1.5 1.9 -1.8
Arm fat mass (right) 0.7 3.0 7.9 2.4 0.7 0.6 -1.6 0.1 -1.9 0.9 -1.2 0.5 -2.8 1.9 2.7 -1.2 -1.1 -2.8
Trunk predicted mass 0.5 3.1 11.5 3.4 1.1 -1.9 -0.1 -0.4 2.1 0.8 -1.0 0.9 -3.1 2.9 1.8 -0.1 -1.3 1.0
Standing height 0.1 1.5 5.5 -0.6 -1.7 -2.2 -1.6 0.5 0.3 2.3 -0.3 1.3 -0.4 -0.6 1.5 -1.0 0.4 0.5
Length of working week for main job 1.4 1.6 5.3 -0.6 -0.7 -0.5 -2.2 2.3 1.1 -1.0 1.8 -0.3 -0.1 -0.3 1.8 -1.4 0.6 1.1
Exposure to tobacco smoke at home 1.3 1.5 5.7 -1.1 0.5 -0.4 -1.3 0.9 -0.2 0.1 -1.1 1.2 -2.4 0.1 1.1 0.2 -2.0 -2.1
Breastfed as a baby 1.7 2.1 8.0 -0.1 -1.6 -0.6 -0.1 -2.1 -0.4 2.3 -2.8 -0.2 -1.0 -1.5 0.8 -2.1 -1.4 -0.5
Tense / ‘highly strung’ 1.0 1.6 5.0 1.6 1.9 -0.8 0.4 1.4 0.6 0.5 -0.4 2.2 -2.1 1.1 -0.0 0.7 -1.3 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.5 1.2 -0.4 0.9 -0.7 1.3 -1.2 0.6 -0.4 0.4 -1.6 0.9 0.2 -0.7 -0.2 0.1
Hair/balding pattern: Pattern 4 0.7 1.6 8.7 -0.6 -1.2 1.2 -0.5 -0.3 -1.2 0.5 -1.4 -1.6 0.4 -2.1 1.0 -2.9 0.7 0.4
Birth weight of first child 0.9 1.6 3.8 1.4 1.4 -1.9 0.3 -0.9 1.7 0.1 -0.3 1.3 -0.8 1.6 -1.4 1.8 -1.8 0.2
Peak expiratory flow (PEF) 1.2 2.7 15.3 -2.3 -0.1 -0.1 -0.1 -0.3 -0.7 -1.1 2.3 -1.2 2.9 -1.2 -1.1 -0.3 3.9 -0.2
Pulse wave reflection index 1.1 1.4 3.9 0.9 -1.8 0.0 0.8 -1.6 -0.6 0.5 -2.0 -1.5 0.1 -1.1 -0.1 -1.8 -0.1 1.6
Ever highly irritable/argumentative for 2 days 0.9 1.1 4.5 1.1 -0.7 1.3 -0.9 1.4 0.6 1.4 0.4 2.1 0.2 0.8 1.5 -0.5 -0.4 0.6
Loud music exposure frequency 1.6 1.8 4.5 -0.2 1.9 -1.0 -1.4 1.4 1.9 0.1 1.4 2.1 -1.6 1.2 -1.0 1.1 -0.6 1.2
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.2 1.6 -0.6 0.2 0.4 -0.7 0.9 1.0 -0.8 -1.1 -1.4 0.4 0.8 -0.9 -0.0 1.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.9 -0.3 -0.5 0.0 -1.3 0.5 -2.2 1.0 0.3 1.6 -0.9 0.5 1.1 -1.1 -0.3 -2.2
Blood clot in the leg (DVT) 0.4 0.5 2.3 -0.2 -0.3 0.4 0.5 -1.0 0.1 -1.2 0.5 -1.1 1.5 -0.1 0.5 -0.8 0.5 0.3
Medication: Paracetamol 0.6 1.0 4.4 -1.2 -1.5 0.4 0.0 1.2 -1.4 0.1 0.8 0.8 -0.0 -0.8 0.3 0.3 0.6 -2.1
Headache pain in last month 0.8 1.4 4.3 0.4 -0.1 -0.9 -1.5 2.1 -0.9 0.6 0.8 2.1 -0.8 0.8 1.2 0.1 0.1 -2.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.8 -1.3 0.3 -0.9 1.2 0.1 -0.5 0.2 -0.1 -0.3 0.3 -1.2 -0.8 -0.0 0.5 0.1
Glaucoma (self-reported) 0.4 0.5 3.6 1.9 -0.5 0.4 0.5 0.4 -0.4 -1.1 -0.6 0.9 -0.4 0.5 -0.0 -0.0 -0.3 -0.0
Gout (self-reported) 0.5 0.7 3.0 -0.3 0.9 -0.1 -0.9 0.3 1.0 -0.4 -0.7 0.4 -1.5 0.6 1.7 0.3 -0.3 -0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 4.5 1.4 0.1 -0.3 -0.5 0.5 0.8 0.3 0.6 1.4 -0.4 2.1 1.1 0.4 -0.7 -0.0
Medication: Amlodipine 0.9 1.3 4.8 1.8 1.8 0.6 1.7 -0.2 0.2 -1.3 -0.1 -2.2 0.7 0.5 -0.8 0.2 0.9 0.6
Medication: Ventolin 100micrograms inhaler 1.1 1.5 6.3 -1.1 -0.4 2.2 -2.5 0.7 0.4 -0.2 1.0 1.7 1.9 -0.6 -0.5 -0.5 0.2 -0.7
Birth weight 0.6 1.2 3.5 1.7 0.6 -0.2 -0.9 0.1 -0.8 0.7 -1.9 0.0 -1.3 1.2 1.6 -0.9 -1.5 -0.7
Chronic bronchitis/emphysema (mother) 1.1 1.3 5.8 -0.2 0.4 -0.7 -1.0 0.8 -1.0 2.4 0.6 0.9 -2.0 0.9 1.8 -0.8 -0.7 -0.3
High blood pressure (siblings) 0.3 0.4 1.2 0.6 0.5 -0.1 0.7 -0.5 0.9 -0.5 -0.9 -1.1 -0.7 0.4 0.7 -0.3 -0.8 -0.0
Forced vital capacity (FVC), Best measure 0.2 0.7 2.7 -0.3 0.7 -1.6 -1.3 1.5 0.4 -0.5 0.5 0.2 0.3 -0.2 0.2 0.1 0.9 1.0
Body fat percentage 1.0 3.8 15.3 1.0 -0.3 1.1 -1.4 -0.3 -3.3 2.0 -1.6 -0.1 -2.4 0.1 3.1 -2.0 -1.2 -3.9
Leg fat percentage (right) 1.0 3.4 12.4 1.8 0.3 1.1 -0.5 -0.4 -2.1 1.5 -1.8 -0.1 -3.0 1.0 3.1 -1.1 -1.8 -3.5
Arm fat-free mass (right) 0.5 2.5 8.0 2.8 0.6 -1.9 -0.1 -1.0 1.6 1.5 -0.7 0.7 -2.3 2.7 2.3 -0.6 -0.9 0.4
Exposure to tobacco smoke outside home 0.6 0.8 2.4 1.1 0.5 1.4 0.5 0.4 -0.6 0.6 -1.1 -0.0 -0.4 1.6 1.4 -0.6 0.5 -0.7
Comparative body size at age 10 0.3 0.9 3.0 0.6 1.0 1.7 -0.5 -0.3 0.7 -0.9 -1.1 -0.9 -1.3 0.4 0.6 0.8 -1.5 1.1
Number of full brothers 0.5 0.6 3.7 -1.1 0.6 -0.2 0.5 -0.3 0.1 0.2 -0.5 0.3 -1.9 -0.2 1.4 0.3 -0.7 -0.8
Worry too long after embarrassment 0.8 1.4 7.0 1.4 -0.8 1.2 -2.6 0.8 0.3 0.4 0.2 0.2 -1.2 1.1 2.1 -1.2 -0.5 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 9.5 -0.4 0.8 -0.8 -0.7 1.3 0.1 0.5 -0.6 1.9 -3.1 -0.5 0.6 -0.8 -1.7 0.5
Wheeze or whistling in the chest in last year 0.5 0.8 3.1 1.0 0.7 1.5 0.3 1.2 -0.7 -1.8 0.5 0.0 -0.4 1.0 -0.7 0.5 -0.4 -1.3
Number of children fathered 1.5 1.7 6.5 -2.5 -1.2 1.2 0.2 1.3 -1.5 -0.4 1.2 0.3 1.5 -1.8 0.3 0.3 1.7 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 3.8 0.4 0.2 -0.5 -1.0 -1.0 0.7 -0.4 0.4 -2.0 -0.6 0.1 0.1 -0.5 -0.4 0.0
Age at first live birth 0.5 0.9 6.8 1.4 -0.2 -0.0 0.9 -0.6 0.1 1.5 -2.6 0.4 -0.3 -0.1 -0.3 -0.4 0.4 0.8
Pulse wave peak to peak time 1.3 1.6 5.7 -0.8 2.2 1.0 -0.8 1.1 0.3 0.0 0.4 2.3 0.2 0.5 1.1 1.3 0.8 -2.4
Health satisfaction 0.2 0.3 1.5 1.1 0.4 0.3 0.2 -0.5 0.0 -0.1 -0.4 0.3 -0.8 1.2 0.7 -0.1 -0.3 -0.2
Shortness of breath walking on level ground 1.0 1.2 7.6 0.2 -1.7 0.4 -0.4 -0.1 -0.9 -0.2 -0.0 1.2 -2.8 0.8 0.6 -0.1 -1.8 -1.0
Qualifications: College or University degree 0.4 1.2 4.0 0.5 0.3 0.6 0.8 -0.0 0.1 -0.4 -0.8 -1.8 1.2 -0.8 -0.3 -1.9 1.6 2.0
Eye problems/disorders: None of the above 0.7 0.8 2.4 -1.5 -0.9 0.6 -0.5 -0.0 0.4 0.2 -0.1 0.5 -1.3 -1.4 -0.3 1.5 -1.2 0.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.0 0.3 1.7 -0.5 0.7 0.1 2.2 -1.4 0.9 -1.3 -0.3 -0.1 -1.2 1.2 0.7 2.1
Emphysema/chronic bronchitis 1.1 1.2 3.1 0.1 -1.6 -0.3 -0.9 0.8 -0.3 1.2 1.0 0.9 1.8 0.5 1.4 -1.5 1.8 -0.5
Medication for pain relief, constipation, heartburn 0.7 1.2 7.1 0.9 1.5 -2.7 1.1 -1.2 0.3 0.1 -0.8 -0.7 -0.8 0.8 -0.8 0.1 -0.7 1.3
Neck or shoulder pain in last month 1.0 1.4 6.2 0.3 -0.8 1.2 -0.9 2.5 -0.6 -1.1 1.7 0.8 -0.0 1.5 1.3 -0.2 0.7 -1.8
Medication: Blood pressure 0.2 0.4 1.0 1.0 -0.2 0.6 -0.1 -0.6 -1.0 0.6 -0.3 0.2 -0.3 0.9 0.7 0.1 0.0 -0.9
Angina (self-reported) 1.0 1.4 3.1 1.5 -1.8 1.2 0.0 0.2 1.6 0.1 0.7 -0.1 1.7 0.4 1.6 -1.4 0.9 1.3
Migraine (self-reported) 0.2 0.2 0.7 0.3 -0.2 0.3 -0.1 -0.1 -0.1 0.6 0.2 0.4 -0.8 0.2 0.6 0.4 -0.2 -0.7
Medication: Ibuprofen 1.6 1.9 5.7 0.6 0.8 2.0 -0.8 2.0 1.2 -1.9 1.5 0.9 0.9 2.4 0.0 1.6 1.2 -0.7
Medication: Allopurinol 0.7 0.9 4.3 -0.6 1.4 0.3 0.7 -0.4 0.6 -0.5 -1.4 1.5 -2.1 0.3 0.6 0.9 -1.0 -0.1
Medication: Omeprazole 0.7 0.8 2.7 -0.8 -0.7 0.9 0.0 -0.4 1.2 -1.6 0.2 -1.4 1.3 -1.1 -0.6 0.3 -0.0 0.1
Medication: Seretide 50 evohaler 0.8 0.9 2.7 -1.1 -0.7 1.4 -0.1 -0.7 -0.9 0.5 0.2 0.7 1.4 -1.0 0.2 -1.3 1.6 0.6
Mean time to correctly identify matches 0.5 0.9 3.5 1.9 -1.1 0.1 -0.7 -0.6 1.5 0.1 -0.1 0.6 -0.4 0.9 0.8 -0.6 -1.1 1.5
Heart disease (mother) 0.6 0.7 2.3 0.9 -0.7 -0.8 -1.2 1.5 0.1 0.6 -0.1 -0.7 -1.1 -0.3 1.0 -1.4 0.1 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.7 -0.3 -0.7 0.3 -0.1 0.2 0.9 -0.4 -0.7 0.2 -0.9 -0.6 -0.7 0.5 -0.8 1.6
Whole body fat mass 0.8 3.3 10.4 1.7 0.1 0.4 -1.5 -0.2 -2.2 1.9 -1.5 0.2 -2.7 1.1 3.2 -1.7 -1.1 -3.2
Leg fat mass (right) 1.0 3.8 12.0 2.5 0.5 0.0 -1.0 -0.3 -1.6 1.6 -2.0 0.2 -3.5 1.9 3.4 -1.4 -1.6 -2.7
Arm predicted mass (right) 0.5 2.6 8.1 2.8 0.5 -1.8 -0.3 -0.9 1.7 1.5 -0.8 0.5 -2.4 2.6 2.4 -0.8 -1.0 0.3
Pulse rate, automated reading 0.3 0.9 2.8 1.2 1.1 -1.4 -0.5 -0.2 0.5 0.9 -0.8 -1.1 -1.7 0.2 0.2 -0.4 -1.2 -1.0
Alcohol intake frequency. 0.8 1.8 7.9 -0.1 -0.1 -1.0 -2.6 1.8 -0.9 0.6 1.8 2.8 0.1 0.8 0.3 1.2 0.0 -1.0
Comparative height size at age 10 0.1 0.6 2.0 -0.6 -0.9 -0.6 -1.3 0.9 -0.1 0.8 0.2 -0.2 0.3 -0.4 1.0 -1.4 -0.0 0.8
Number of full sisters 1.0 1.3 3.7 0.1 0.5 -1.9 -0.8 0.8 -0.9 1.4 0.2 0.1 -0.6 0.6 1.9 -1.8 -0.0 -1.9
Suffer from ‘nerves’ 0.6 0.9 4.3 -0.6 1.3 0.1 -0.2 0.4 -2.0 -0.5 0.6 -1.0 -0.7 0.5 -0.4 0.4 0.2 -2.1
Overall health rating 0.4 0.8 3.8 -0.1 0.0 -0.6 0.1 1.0 -1.5 -1.2 0.8 -0.3 0.1 0.9 0.2 1.1 0.9 -2.0
Chest pain or discomfort 0.7 1.0 7.0 -0.1 0.8 2.6 -0.2 -1.1 -1.0 -1.0 -0.3 -0.3 0.3 -0.7 0.4 0.3 1.5 -1.0
Had major operations 0.5 0.6 2.1 0.1 -0.8 1.4 0.3 0.7 0.6 -0.4 -0.1 -0.2 -0.2 -0.4 1.4 -1.4 -0.2 0.7
Age at last live birth 1.7 2.5 16.6 1.0 0.3 0.9 1.3 -1.8 -1.0 2.5 -4.1 1.2 -0.4 -1.6 -0.7 -0.4 -1.1 0.6
Family relationship satisfaction 2.8 3.4 14.1 1.9 2.0 -2.6 -0.5 1.9 1.0 0.7 -0.7 1.3 -3.8 1.4 1.8 -0.9 -3.0 0.7
Leg pain on walking 0.9 1.1 4.7 1.2 -1.0 0.2 -0.5 0.6 0.6 0.7 0.5 2.2 -1.2 1.9 1.2 1.0 -0.2 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 5.7 0.2 0.3 0.2 -0.0 -2.4 0.7 2.0 -1.9 0.5 -0.8 -0.3 2.1 -0.8 -1.1 0.0
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.1 -1.9 -0.2 -1.8 0.0 -0.2 -0.2 0.9 -1.3 -0.6 -2.0 -1.7 1.5 -1.0 -2.0 -0.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 4.1 -1.9 1.6 1.2 0.4 0.3 -0.7 -1.3 0.5 0.8 1.7 -0.6 -2.0 1.2 0.7 -0.4
Medication: Aspirin 0.4 0.5 1.4 -0.4 -1.1 1.2 0.5 1.0 -0.3 0.8 0.0 0.7 0.9 -0.2 0.7 0.2 0.4 -0.9
Supplements: Vitamin C 1.1 1.3 4.7 1.2 -1.2 0.4 -0.3 0.9 0.9 0.2 -0.7 1.6 -2.2 0.2 1.7 -0.3 -1.9 1.1
Knee pain experienced in last month 1.4 2.2 5.3 1.5 0.7 0.4 -1.7 0.3 2.3 -0.9 -0.6 1.5 -2.3 2.1 1.0 1.8 -1.4 1.6
Hypertension (Self-reported) 0.1 0.4 1.7 0.3 -0.3 1.0 1.3 -0.3 -0.5 -0.3 0.6 -1.0 0.4 0.9 0.3 0.1 0.3 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.7 0.5 -1.8 -0.3 -1.4 -0.7 0.5 0.0 -1.8 0.1 -0.4 -0.9 0.9 -0.4 -1.9 -0.2
Illnesses of father: Heart disease 1.0 1.4 6.6 -2.3 -0.4 -0.6 -0.3 1.3 -1.3 -1.3 1.1 -0.9 0.2 0.2 0.9 0.2 0.7 -2.6
Illnesses of siblings: Diabetes 0.6 0.7 2.9 0.5 -0.7 0.3 1.0 -0.0 -0.3 1.7 -1.4 0.8 -0.0 1.2 0.9 0.4 0.0 -0.8
Smoking status: Previous 0.9 1.3 8.4 -2.9 0.5 0.7 0.2 -0.4 -1.4 -1.3 0.0 -0.2 -0.3 -1.9 -1.4 0.5 -0.4 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.7 -0.8 1.3 0.3 0.1 -0.3 0.3 0.4 -0.1 0.8 0.7 -0.4 -0.3 0.6 1.3 0.3
Whole body fat-free mass 0.5 3.0 11.8 3.4 1.0 -1.9 -0.5 -0.3 1.5 0.8 -0.9 0.8 -3.0 3.1 1.9 -0.2 -1.1 0.5
Leg fat-free mass (right) 0.5 2.5 11.3 3.4 1.1 -1.7 -1.2 0.1 0.6 0.3 -0.8 0.9 -2.6 3.0 1.4 -0.2 -0.7 -0.1
Arm fat percentage (left) 0.8 3.1 11.8 1.8 0.7 1.2 -1.8 -0.1 -2.7 0.8 -1.2 -0.1 -2.5 0.8 2.5 -1.6 -0.9 -3.4
Average weekly red wine intake 1.2 1.8 5.8 -0.1 -1.5 0.8 1.6 -2.4 -0.1 0.4 -1.4 -1.7 -1.0 -2.0 0.8 -2.0 -0.7 0.6
Handedness (chirality/laterality): Left-handed 1.8 2.2 6.0 0.1 1.8 -1.5 0.2 -2.5 -0.2 2.2 -0.9 -0.3 -2.3 0.3 1.7 -1.5 -2.1 0.8
Mood swings 1.0 1.7 6.4 0.5 0.5 2.1 -0.1 1.8 0.4 -1.4 1.8 1.1 0.6 1.6 -1.2 2.5 0.2 -0.3
Loneliness, isolation 0.9 1.2 5.0 -0.1 1.4 -0.3 -0.1 2.2 -0.5 -1.7 2.1 0.2 0.2 1.3 -0.7 0.7 0.4 -0.9
Long-standing illness, disability or infirmity 1.0 1.5 4.9 1.2 0.2 0.2 0.5 1.1 -0.4 -1.4 1.4 0.5 0.6 2.2 -1.4 2.2 1.4 -1.4
Ever had bowel cancer screening 2.2 2.6 6.3 -0.3 -2.5 -0.3 1.2 -1.8 2.4 1.2 -1.2 -1.9 -1.3 -1.5 2.0 0.2 -2.1 1.7
Diabetes diagnosed by doctor 0.6 1.0 3.6 0.9 1.6 0.5 -0.4 -0.2 0.1 -1.1 -0.3 1.1 0.1 1.5 -1.2 1.9 -0.6 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 4.4 0.8 -0.2 -0.9 -0.4 0.4 -1.7 2.1 -1.1 0.6 -1.5 0.9 1.2 -1.2 -0.5 -1.1
Friendships satisfaction 0.8 1.0 3.4 0.6 0.8 -0.4 -0.9 1.1 1.8 1.0 0.7 0.4 -0.8 -0.2 1.8 -1.2 -0.1 1.3
Qualifications: nursing, teaching 1.3 2.1 12.6 3.6 1.1 1.9 0.8 -1.7 0.7 0.8 -2.0 0.3 -0.3 1.8 -0.2 -0.3 -1.0 0.9
Commuting to job workplace: Walk 0.9 1.0 5.5 1.5 1.2 0.4 1.2 -0.3 -0.5 -1.1 -0.1 0.1 1.0 0.9 -2.4 0.9 0.3 0.2
Eye problems/disorders: Cataract 0.8 0.9 3.5 -0.8 -0.8 -0.2 -0.3 0.9 0.7 0.4 1.6 -1.9 0.4 -1.3 0.3 -1.5 0.6 0.4
Mouth/teeth dental problems: Mouth ulcers 1.2 1.8 5.6 -1.7 -0.8 1.9 -1.1 -1.0 -0.5 -0.7 0.6 -2.0 1.9 -2.4 -0.2 -0.3 1.8 -0.5
Medication for cholesterol 0.6 0.9 6.5 -0.8 -0.6 0.1 -1.2 1.4 -1.3 0.5 0.1 2.5 0.3 -0.0 0.1 -0.6 0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.0 -0.1 -0.6 0.1 -1.3 0.3 1.4 1.2 -0.0 0.2 0.3 -1.4 1.2 0.4 -0.6 1.3
Back pain experienced in last month 0.7 1.0 3.8 0.6 -0.3 1.9 -0.8 1.4 -0.8 -0.4 0.4 1.5 0.5 1.7 0.1 0.6 0.6 -0.8
Mineral and other dietary supplements 0.7 1.0 5.1 0.8 2.3 0.0 0.5 -0.1 -0.3 -1.2 0.9 0.8 0.3 1.6 -0.9 1.2 0.9 -0.4
Breast cancer (self-reported) 0.9 1.0 4.3 0.4 -0.6 -0.1 -1.0 0.9 -2.1 -0.0 -1.2 1.5 0.4 0.8 -1.8 0.7 -0.4 0.6
Asthma (self-reported) 0.6 1.1 5.3 -0.0 1.0 0.6 -1.3 0.5 1.5 -2.3 2.0 0.6 0.7 0.5 -0.2 0.4 0.1 0.2
Osteoporosis (self-reported) 0.6 0.8 6.0 -0.3 -0.4 0.1 0.3 0.8 -1.1 -0.9 -0.2 -2.4 0.5 -0.5 0.1 -1.1 0.3 -0.8
Osteoarthritis (self-reported) 0.8 1.0 5.0 -0.8 -1.5 0.1 -0.9 1.9 -0.6 0.2 0.5 0.4 -0.9 0.4 1.0 0.6 0.0 -2.2
Medication: Aspirin 0.3 0.4 2.0 0.0 -0.4 1.4 0.3 1.3 0.0 0.1 0.2 0.0 0.9 0.3 0.6 0.4 0.2 -0.5
Medication: Gliclazide 0.5 0.6 3.1 0.2 -0.7 0.5 0.1 -0.7 -0.1 0.7 0.7 0.1 1.8 1.5 -0.1 0.9 0.2 0.2
Illnesses of father: None of the above (group 1) 0.3 0.4 1.2 0.1 0.3 -0.3 -0.3 -0.9 0.9 0.2 -0.3 0.9 0.1 0.3 -0.5 0.5 -1.1 1.0
Smoking status: Current 0.4 0.6 1.6 0.6 1.2 -0.0 -0.6 1.1 0.4 -1.1 1.1 -0.7 -1.0 1.3 0.5 -0.2 0.6 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 8.8 0.3 1.1 -1.7 1.0 0.5 -1.4 0.1 -0.3 -1.6 0.2 -0.1 0.9 -0.8 3.0 -1.1
Whole body water mass 0.5 2.8 11.0 3.3 0.9 -1.8 -0.5 -0.4 1.6 0.8 -0.9 0.8 -2.9 3.0 1.9 -0.2 -1.1 0.5
Leg predicted mass (right) 0.5 2.5 11.1 3.3 1.1 -1.8 -1.2 0.1 0.6 0.3 -0.8 1.1 -2.7 3.0 1.5 -0.2 -0.8 -0.1
Arm fat mass (left) 0.8 3.2 9.1 2.5 0.9 0.2 -1.6 -0.2 -1.7 1.2 -1.3 0.6 -3.0 1.8 2.9 -1.4 -1.3 -2.8
Number of self-reported non-cancer illnesses 0.3 0.5 1.8 1.0 -0.8 -0.7 -0.4 0.1 1.0 -0.5 0.0 0.1 -0.3 1.0 0.6 0.2 -1.3 -0.2
Average weekly champagne plus white wine intake 0.8 1.1 5.1 0.1 -0.4 -0.1 0.1 -2.3 -0.2 1.5 -1.4 -0.1 0.5 -0.5 1.7 -2.0 -0.3 -0.2
Miserableness 0.8 1.4 7.0 -0.0 0.6 1.9 -0.9 2.6 -1.2 -0.5 0.2 1.6 -1.0 0.7 0.6 1.2 0.1 -1.3
Guilty feelings 0.2 0.4 0.8 -0.8 0.4 0.8 0.0 0.9 -0.7 -0.4 0.6 0.4 -0.2 -0.1 -0.7 0.7 -0.8 -0.5
Wears glasses or contact lenses 1.2 1.4 6.2 -0.3 -2.0 0.6 0.4 -0.6 0.1 0.8 -1.5 -0.9 -0.1 -1.9 1.1 -2.5 -0.7 0.8
Ever taken oral contraceptive pill 0.5 0.5 1.6 1.1 -0.0 1.3 -1.3 0.8 1.0 0.3 -0.2 0.8 0.4 0.5 0.7 0.1 0.1 0.4
Hearing aid user 0.6 0.7 3.4 1.4 1.9 -0.2 0.6 0.2 0.8 -0.9 -0.4 0.5 0.4 1.4 0.5 -0.7 -0.3 -0.1
Mother’s age at death 0.8 1.0 4.3 0.4 -1.2 -0.6 -0.3 -0.3 2.1 0.4 0.2 1.2 0.6 0.3 -1.1 2.0 -0.3 1.1
Financial situation satisfaction 1.1 1.4 3.3 1.8 1.2 -1.0 -0.9 0.9 -0.5 -0.6 0.5 -0.4 -1.4 1.8 1.5 -1.7 -1.2 -0.6
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.8 -0.2 -0.5 -0.1 0.1 0.7 -0.6 -0.9 0.7 -1.3 0.5 -0.0 -0.2 -0.1 -0.3 -0.3
Commuting to job workplace: Public transport 1.0 1.1 4.3 0.1 -0.4 1.8 -1.1 1.0 -0.4 -0.9 1.0 2.1 0.3 0.4 -1.4 1.5 -0.2 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 4.1 2.0 -0.2 1.1 0.2 -0.1 -0.0 -0.8 -0.0 0.8 0.3 0.8 0.6 -1.1 1.3 -0.2
Medication: Blood pressure 0.6 1.1 3.3 0.5 -1.3 1.2 0.0 -0.2 1.8 -0.9 1.8 -1.4 1.4 0.6 -0.1 0.6 0.3 0.8
Pain type(s) experienced in last month: Hip pain 1.6 2.1 8.1 -0.7 -0.6 -0.5 -1.7 1.0 -2.1 -0.3 1.7 0.9 1.2 0.7 1.1 -1.2 2.3 -2.8
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.0 -0.4 -1.3 -1.4 -0.6 0.1 0.7 0.8 -0.3 -1.4 -1.0 -1.3 0.2 -1.1 -0.8 0.4
High cholesterol (Self-reported) 0.5 1.0 4.2 0.5 1.0 -0.5 -0.7 -1.1 1.5 -2.0 0.9 -1.5 -0.6 0.8 0.5 -0.1 -0.6 0.3
Medication: Bendroflumethiazide 0.8 1.3 6.3 -0.1 -1.4 2.1 1.2 -1.1 -0.2 0.5 1.4 -0.1 2.5 0.3 -0.8 0.3 0.6 -0.0
Medication: Paracetamol 0.5 0.8 3.8 -0.8 -1.2 0.4 -0.2 0.9 -1.2 0.3 0.4 1.3 -0.5 -0.3 0.7 0.3 0.3 -1.9
Medication: Lisinopril 1.2 1.5 5.4 2.3 1.8 -0.2 0.9 -1.8 1.6 0.2 -0.9 -2.2 0.1 1.0 0.5 -0.3 0.4 -0.1
Medication: Atorvastatin 0.9 1.1 7.8 0.6 1.5 -1.8 0.4 0.7 0.3 -1.3 0.9 -2.8 -0.0 0.3 -0.2 -0.1 0.0 -0.1
Illnesses of father: High blood pressure 0.3 0.3 1.9 0.1 -0.5 0.3 -0.8 0.7 0.1 -0.3 -0.1 0.5 -1.4 0.5 0.4 0.0 -0.9 -0.0
Alcohol drinker status: Never 0.6 0.8 4.7 -0.8 0.6 -1.8 0.4 0.0 -0.4 0.2 0.2 2.2 0.6 -0.0 -0.6 0.9 0.3 -0.4
Ever smoked 0.8 1.4 3.9 -2.0 1.2 1.1 -0.3 0.9 -0.8 -1.5 -0.4 1.0 -1.8 -0.4 -1.1 1.3 -1.7 -0.7
Basal metabolic rate 0.5 2.9 11.2 3.3 1.1 -1.6 -0.7 -0.2 1.0 1.0 -1.0 1.0 -2.9 3.0 2.2 -0.3 -1.0 -0.1
Leg fat percentage (left) 0.9 3.4 13.0 1.5 0.5 1.3 -0.6 -0.2 -2.1 1.0 -1.7 0.0 -3.0 1.1 3.2 -1.0 -2.0 -3.6
Arm fat-free mass (left) 0.5 2.5 8.8 2.7 0.8 -1.3 -0.3 -0.4 1.8 0.8 -0.4 0.9 -2.4 3.0 2.5 -0.4 -1.0 0.4
Number of operations (self-reported) 0.3 0.5 2.8 0.4 0.2 -0.1 0.9 -0.7 -0.0 1.0 -1.7 0.7 0.7 -0.2 0.2 -0.2 -0.6 0.7
Average weekly beer plus cider intake 0.6 0.9 2.9 0.4 1.7 -0.8 1.1 1.2 0.2 -0.9 -0.5 -0.6 -1.1 1.0 -0.7 1.2 -1.1 0.4
Irritability 0.9 1.5 4.6 0.1 0.8 1.5 0.2 2.1 0.5 -1.5 1.5 -0.3 0.4 0.5 -1.8 2.1 0.8 1.0
Risk taking 1.3 1.8 6.8 1.2 2.6 0.1 0.1 0.5 1.1 -1.3 -0.6 0.2 -2.6 1.8 -0.0 1.5 -1.4 -1.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 6.4 -0.7 0.5 -0.2 1.5 -0.3 0.2 -0.7 -1.4 0.3 -1.8 -1.2 0.3 0.0 -2.5 0.1
Fractured/broken bones in last 5 years 0.7 0.9 2.9 0.9 -0.3 1.2 -0.5 -1.7 0.4 0.7 -1.5 -0.5 -1.3 0.2 1.0 -1.4 -1.0 -0.0
Age started oral contraceptive pill 1.4 1.8 4.6 -1.7 -1.7 0.2 0.7 -1.6 -0.8 1.6 -1.5 -1.4 0.3 -2.2 0.8 -2.1 -0.0 0.1
Diastolic blood pressure, automated reading 0.7 2.1 6.8 1.2 0.5 1.3 0.7 -2.1 1.9 -1.1 -1.4 -2.6 -1.8 -1.5 -0.6 -0.2 -1.5 1.3
Ever depressed for a whole week 0.7 0.9 3.1 0.9 0.6 1.5 -1.8 1.2 -0.0 0.1 0.8 1.3 0.1 0.2 1.3 -1.0 -0.1 -0.3
Unable to work because of sickness or disability 0.9 1.2 3.8 1.4 -0.2 -1.2 0.5 0.3 -0.7 1.5 -1.0 0.8 -1.4 1.7 1.9 -1.1 -0.3 0.3
Commuting to job workplace: Cycle 0.5 0.6 2.2 -0.1 0.8 -1.5 -1.3 -0.1 0.0 -0.2 0.2 1.5 -0.3 -0.1 -0.8 1.2 -0.7 -0.1
Myopia 0.9 1.4 5.8 1.4 -0.8 -1.0 1.8 -0.6 -0.6 0.4 -2.4 -0.8 -1.0 -0.5 0.1 -0.9 -1.2 1.6
Vascular/heart problems diagnosed by doctor 0.2 0.6 2.3 -0.8 1.5 -1.2 -0.9 0.6 0.2 -0.2 -0.4 0.9 -0.7 -0.8 -0.8 0.4 -0.4 0.5
Cholesterol lowering medication 0.6 0.9 2.4 1.6 0.8 -1.2 1.4 -1.2 1.0 -0.9 -0.4 -1.3 -0.2 0.9 0.8 -0.6 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.1 -0.5 -0.9 1.1 0.4 -0.2 1.2 -1.5 0.6 -1.5 1.8 -0.9 -0.6 0.7 0.7 0.2
Pain experienced in last month 0.8 1.3 6.1 -0.4 1.3 -1.1 1.1 -1.9 0.1 -0.1 0.6 -2.5 1.0 -0.6 -1.8 -0.1 0.1 1.0
Supplements: Calcium 1.1 1.3 4.6 -0.2 -2.1 1.3 0.8 1.2 0.1 -0.1 -0.1 -1.0 -0.1 0.5 2.0 -1.7 -1.1 1.0
Basal cell carcinoma (self-reported) 1.0 1.2 4.0 -1.9 -0.3 -1.2 0.8 1.3 -1.5 -0.6 0.1 0.4 2.0 -1.7 -0.3 -0.5 -0.0 0.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.3 0.9 -0.6 0.3 -0.1 -0.2 -0.7 -0.4 1.3 -0.1 -0.1 1.2 1.3 -1.8 1.7 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 3.0 -0.0 -0.1 0.5 0.5 -1.1 0.1 -1.5 0.6 -1.3 1.7 -0.4 0.5 -0.7 0.9 0.1
Heart disease (siblings) 1.7 2.1 7.6 -2.8 -0.5 -1.4 -1.0 0.4 -0.4 -0.9 1.3 2.6 0.1 -1.8 -1.9 2.0 0.0 -0.3
Alcohol drinker status: Previous 0.5 0.6 2.2 0.7 1.3 -1.2 0.0 0.5 -0.2 -0.4 0.3 0.4 0.8 1.2 0.3 0.4 -0.3 -1.5
Pack years of smoking 0.5 0.7 2.8 0.6 1.7 1.1 0.9 -0.1 0.5 -1.5 -0.0 -0.7 -0.7 0.8 -0.5 0.5 0.6 0.9
Impedance of whole body 0.8 4.2 16.7 -4.1 -2.0 1.0 -1.0 0.5 -2.8 1.7 0.4 -0.1 2.4 -4.1 -0.1 -1.3 1.5 -1.8
Leg fat mass (left) 0.9 3.7 12.3 2.4 0.5 0.1 -1.1 -0.2 -1.7 1.4 -1.8 0.3 -3.3 2.0 3.5 -1.4 -1.6 -2.8
Arm predicted mass (left) 0.5 2.4 8.9 2.7 0.8 -1.4 -0.3 -0.6 1.8 0.9 -0.3 1.0 -2.2 3.0 2.3 -0.2 -1.1 0.2