Hub : Genes

BMP2K

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0719	0.0304	2.0e-03	0.009	NA	0.013	NA	0.015	7.3e-02	NA	4.0e-02	NA	2.9e-02
2	METSIM	Adipose	0.0367	0.0147	4.4e-04	0.016	0.013	0.029	0.017	0.025	1.4e-03	4.4e-03	2.7e-05	1.2e-03	9.1e-05
3	NTR	Blood	0.0151	0.0077	4.4e-03	0.000	0.002	0.000	0.002	0.001	5.1e-01	4.3e-02	2.1e-01	6.4e-02	1.8e-01
4	YFS	Blood	0.0608	0.0180	5.8e-11	0.038	0.042	0.051	0.045	0.048	1.7e-12	1.3e-13	3.4e-16	1.2e-14	2.0e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.4	0.2	1.2	0.6	0.7
Bipolar Disorder or Schizophrenia	0.1	0.4	0.7	0.2	0.9	-0.1	0.8
Depressed Affect (Nagel 2018)	0.7	1.5	4.7	-0.4	1.0	2.2	0.1
Depression (Nagel 2018)	0.3	0.5	0.6	-0.6	0.8	0.8	-0.5
Intelligence (Savage-Jansen 2018)	1.1	3.5	6.1	1.9	1.5	-1.4	-2.5
Neuroticism (Nagel 2018)	1.1	2.5	6.6	-0.5	1.8	2.6	-0.2
Schizophrenia (2018)	0.1	0.1	0.4	0.1	0.1	-0.6	0.4
Schizophrenia vs Biploar Disorder	1.3	1.8	4.2	-0.8	-2.0	-0.6	1.4
Worry (Nagel 2018)	0.3	0.6	1.5	-0.1	0.8	1.2	-0.4
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	-0.9	-0.2	0.7	1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.3	-0.2	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	-0.0	0.2	-0.1	0.9
Crohns Disease (2017)	0.4	0.9	3.4	-0.2	0.3	1.8	-0.5
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.1	-0.5	0.1	0.0
Ulcerative Colitis (UC)	0.3	0.5	1.5	0.4	-0.5	-1.2	0.5
Major Depression (MDD)	0.1	0.1	0.3	0.3	0.3	-0.5	-0.1
Reaction Time	1.4	2.6	5.4	2.3	0.1	-1.7	-1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.6	0.8	1.6	-0.6	-1.6
Breast Cancer	0.3	0.7	1.9	0.7	0.5	0.5	-1.4
Ovarian Cancer	0.3	0.4	1.0	-0.0	1.0	0.5	-0.4
Prostate Cancer	1.3	1.9	4.2	2.1	-0.5	-1.1	-1.3
Age at First Birth	0.5	0.8	1.7	-1.3	-1.0	0.4	0.5
Bipolar Disorder (2011)	1.0	1.0	1.2	-1.0	1.0	1.1	0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.5	1.1	0.8	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.4	0.2	-0.3	0.5
Crohns Disease (2012)	0.4	0.6	1.4	-0.6	-0.2	0.8	-1.2
Mean Putamen Volume	4.7	5.4	8.5	2.1	2.9	-2.0	-2.2
Fasting Glucose	0.7	0.8	1.5	1.0	-0.9	-1.2	-0.2
HbA1C	0.7	0.8	1.6	0.7	0.3	-1.3	-0.9
HDL Cholesterol	0.2	0.3	0.7	-0.3	-0.7	0.2	0.8
LDL Cholesterol	0.8	1.3	2.3	1.5	0.4	-1.4	-0.8
Lupus	0.1	0.1	0.2	-0.1	0.5	0.4	0.3
Neuroticism (2016)	1.5	2.1	4.7	1.6	0.7	-0.9	-2.2
Primary Biliary Cirrhosis	1.0	1.5	2.1	1.5	1.1	-1.1	-1.2
Rheumatoid Arthritis	2.0	2.7	4.7	-2.2	-1.7	0.8	1.6
Schizophrenia (2014)	0.1	0.3	0.8	0.1	0.9	-0.3	0.4
Triglycerides	0.5	0.8	1.5	1.2	-0.1	-1.0	-0.8
Type 2 Diabetes (T2D) (2012)	1.2	1.3	2.2	1.1	1.5	-1.1	-0.9
Ulcerative Colitis	0.6	0.9	2.6	1.0	0.3	-1.6	0.0
Blood Eosinophil Count	0.5	4.2	5.2	2.2	1.3	-2.3	-2.2
Blood Platelet Count	0.0	0.3	0.9	-0.3	-0.5	-0.9	-0.2
Blood Red Count	1.2	11.7	27.0	3.4	0.3	-5.2	-2.8
Blood White Count	1.5	11.2	16.2	4.0	1.4	-3.3	-3.9
Heel T-Score	1.4	11.0	15.4	3.8	3.9	-0.9	-3.6
BMI	0.2	0.9	2.9	-1.7	0.2	0.4	0.7
Height	0.1	1.2	2.9	-1.0	-1.7	0.4	0.8
Waist Hip Ratio (WHR)	0.1	0.4	1.1	-0.5	-0.6	0.2	1.0
Systolic Blood Pressure	0.6	3.0	5.5	2.0	-1.4	-2.4	-0.5
Smoking Status	1.4	3.2	7.2	-1.9	0.9	2.7	1.1
Allergy or Eczema	0.5	1.3	2.9	0.5	1.7	-0.6	-1.2
Cardiovascular Disease	0.6	1.9	3.4	1.7	0.7	-0.8	-1.8
Hypothyroidism (self reported)	0.2	0.4	1.0	-0.2	1.0	0.6	-0.5
Respiratory disease	0.8	1.8	2.6	1.5	1.6	0.3	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.4	0.4	-1.6	-0.8	-0.8
Lung FEV1/FVC ratio	0.4	2.1	8.2	-0.2	0.3	-2.9	0.4
Lung FVC	2.2	11.3	15.1	-3.9	-2.3	3.6	3.5
Neuroticism	0.5	1.1	3.2	-0.3	1.1	1.8	-0.0
Chronotype (morning person)	0.1	0.1	0.1	0.4	-0.2	0.4	-0.4
Hair Pigment	1.8	50.7	161.3	-2.7	5.6	12.7	1.7
Tanning	0.1	0.7	1.0	-1.0	-1.0	0.3	0.9
Hand grip strength (left)	0.2	0.5	1.1	0.6	-0.7	-1.1	-0.1
Number of treatments/medications taken	1.1	2.0	3.3	1.8	1.1	-0.9	-1.6
Average weekly spirits intake	0.4	0.5	0.9	-0.3	0.5	-0.9	0.9
Sensitivity / hurt feelings	1.7	2.8	6.0	-1.2	1.6	2.4	1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.0	1.0	0.4	-1.1
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.8	0.6	0.4	0.3
Relative age of first facial hair	2.7	5.5	10.0	1.5	-3.1	-3.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.2	-0.2	0.9	-0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.9	-0.3	1.2	0.2
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	1.0	-1.4	-1.8	-0.4
Systolic blood pressure, automated reading	0.5	1.5	3.9	0.6	-2.0	-1.1	0.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	4.8	-0.3	-2.2	-0.9	-0.3
Angina	1.1	1.5	2.7	1.5	1.6	0.0	-1.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.1	-0.2	-0.1	-0.5
Vitamin and mineral supplements	0.3	0.4	1.3	0.5	-1.1	0.2	0.4
Supplements: Zinc	0.7	0.7	2.3	0.1	1.5	0.1	-0.7
Medication: Co-codamol	0.7	0.8	2.4	0.6	0.6	-0.5	-1.5
Medication: Metformin	0.2	0.3	0.7	0.4	-0.8	-0.5	-0.4
Diabetes (father)	2.5	3.1	5.3	-2.3	-0.5	2.1	1.6
Diabetes (mother)	0.4	0.5	1.9	0.1	0.2	-1.4	0.1
Severe depression (siblings)	0.7	0.8	2.0	-0.7	0.6	1.4	0.7
Pack years adult smoking proportion	0.6	0.9	2.7	-0.6	0.4	1.6	0.7
Impedance of leg (right)	0.3	1.4	2.2	1.2	1.5	-1.2	-0.7
Leg fat-free mass (left)	0.3	1.3	2.6	-1.4	-1.6	0.6	0.5
Trunk fat percentage	0.1	0.5	1.1	0.6	1.0	-0.5	-0.6
Hand grip strength (right)	0.4	1.0	2.6	-0.5	-1.6	-0.3	1.1
Townsend deprivation index at recruitment	2.2	3.0	9.9	-1.3	0.4	3.1	0.6
Current tobacco smoking	2.5	4.1	10.1	-2.3	0.5	3.2	1.0
Average weekly fortified wine intake	0.1	0.1	0.5	0.1	-0.7	0.2	0.2
Maternal smoking around birth	1.6	2.3	3.0	-1.7	1.4	1.7	1.3
Fed-up feelings	0.6	1.1	2.8	-0.9	0.3	1.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.6	0.5	0.8	-0.3
Relative age voice broke	1.2	1.9	4.3	0.7	-2.1	-1.6	-0.2
Taking other prescription medications	0.3	0.5	0.7	0.8	-0.4	0.7	-0.9
Age when periods started (menarche)	1.0	2.5	4.2	-0.9	-2.0	-1.8	1.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.4	1.5	0.5	-1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	10.7	2.0	3.3	-0.3	-1.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.7	-0.0	0.2	0.2
Qualifications: CSEs or equivalent	2.5	3.3	7.6	-1.7	-0.9	2.8	1.4
Serious illness, injury or assault to yourself	0.7	0.8	1.3	0.8	1.2	-0.7	-0.8
High blood pressure	0.3	0.8	1.9	1.4	0.2	-0.7	-0.9
Hayfever, allergic rhinitis or eczema	1.7	3.7	7.1	1.5	2.7	-1.0	-2.1
Multivitamins +/- minerals	0.5	0.6	1.9	-0.3	1.4	-0.5	-0.4
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.6	1.1	0.4	-0.5
Supplements: Glucosamine	0.3	0.4	1.1	-0.3	1.0	0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-1.0	-0.9	-0.1	-0.2
Medication: Atenolol	0.7	0.9	1.6	0.7	-1.2	-1.2	-0.3
Medication: Levothyroxine sodium	0.4	0.6	0.8	0.9	-0.8	-0.8	-0.6
Sitting height	0.1	0.4	0.7	0.4	-0.5	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	3.2	-0.1	1.8	0.2	0.2
High blood pressure (mother)	2.2	3.0	5.5	2.2	1.0	-0.9	-2.4
Body mass index (BMI)	0.1	0.4	0.9	-0.9	-0.2	0.6	0.6
Impedance of leg (left)	0.2	1.2	3.1	1.0	1.8	-0.7	-0.3
Leg predicted mass (left)	0.3	1.4	2.6	-1.5	-1.6	0.6	0.6
Trunk fat mass	0.0	0.1	0.3	-0.1	0.5	-0.2	-0.1
Waist circumference	0.0	0.2	0.3	-0.3	0.5	0.5	0.1
Number of incorrect matches in round	0.0	0.1	0.3	-0.1	-0.5	0.1	-0.2
Past tobacco smoking	0.3	0.6	1.6	-0.2	-1.3	-0.5	0.7
Alcohol usually taken with meals	1.6	2.5	7.0	1.4	-0.4	-2.7	-0.8
Nervous feelings	0.3	0.5	1.5	-0.4	-0.4	1.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1
Hearing difficulty/problems with background noise	0.6	0.9	3.1	-0.3	0.8	1.8	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.8	-0.9	0.5	0.5
Had menopause	3.3	4.2	9.1	1.9	-0.5	-3.0	-1.9
Had other major operations	0.1	0.1	0.3	-0.6	0.1	0.4	-0.2
Forced vital capacity (FVC)	1.4	5.5	7.8	-2.8	-1.7	2.1	2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	9.4	1.9	3.1	-0.2	-2.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.3	0.9	0.3	-0.7
Qualifications: None of the above	1.1	2.3	4.4	-1.1	-0.7	1.8	2.1
Financial difficulties in last 2 years	0.7	0.9	1.6	-1.3	-0.6	1.2	-0.3
Mouth/teeth dental problems	0.3	0.5	1.3	0.2	0.4	-1.1	-0.8
Heart attack	0.5	0.7	1.2	0.4	0.5	1.1	1.0
Allergy	2.7	6.2	8.8	-2.6	-3.0	1.2	2.9
Pain all over the body in last month	0.5	0.5	1.9	-0.1	1.4	0.4	-0.0
Diabetes (self-reported)	0.5	0.8	0.8	0.8	-0.9	-0.9	-0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.2	1.1	1.8	-1.3	-1.4
Medication: Ramipril	0.2	0.2	0.4	0.7	-0.0	-0.6	0.1
Medication: Simvastatin	2.9	4.2	7.5	2.7	0.4	-2.0	-2.2
Fluid intelligence score	0.3	0.7	1.9	0.3	0.7	-0.2	-1.4
Illnesses of siblings	0.8	1.1	2.1	1.2	0.6	-0.8	-1.4
Neuroticism score	0.5	1.1	3.6	-0.5	0.6	1.9	0.1
Weight	0.1	0.4	1.0	-1.0	-0.4	0.4	0.3
Impedance of arm (right)	0.5	2.2	3.7	1.9	1.7	-0.2	-1.4
Arm fat percentage (right)	0.1	0.3	0.7	-0.0	0.8	0.6	-0.2
Trunk fat-free mass	0.5	2.8	5.8	-2.4	-1.8	0.9	1.2
Hip circumference	0.1	0.3	0.7	-0.3	0.8	0.4	-0.7
Time employed in main current job	0.4	0.4	1.3	0.4	0.3	1.1	-0.4
Alcohol intake versus 10 years previously	0.6	0.8	1.9	-1.0	0.7	1.4	0.0
Father’s age at death	0.5	0.6	1.6	0.1	-0.7	-1.3	-0.7
Worrier / anxious feelings	0.3	0.7	1.0	0.9	0.8	-0.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.3	1.9	1.9	-0.5	-2.7
Falls in the last year	1.0	1.4	3.5	-0.5	1.9	1.3	0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-0.6	-0.3	-0.1	1.2
Number of live births	0.3	0.4	0.5	-0.7	-0.6	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	7.0	-2.6	-1.5	1.2	2.5
Pulse rate	0.3	0.5	0.9	1.0	-0.7	-0.7	-0.5
Happiness	1.7	2.0	3.0	-1.4	-1.7	1.2	1.3
Noisy workplace	0.3	0.3	0.9	-0.3	0.5	-0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	0.9	-0.9	-1.3	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	0.4	-1.1	-1.1	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	0.4	-1.4	0.3	-0.1
Asthma	0.5	1.1	1.7	1.1	1.3	0.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.2	0.0	1.5	1.4	0.1
Medication: Cholesterol lowering	1.3	2.0	4.0	2.0	0.6	-1.4	-1.3
Depression (self-reported)	1.6	2.0	3.7	-1.4	-1.9	1.2	0.9
Medication: Lansoprazole	0.8	0.9	2.4	0.4	-1.6	-0.6	0.8
Prospective memory result	0.8	1.0	1.6	1.3	0.7	-1.2	-0.5
Lung cancer (father)	0.9	1.1	2.2	0.2	1.5	0.5	-1.3
Illnesses of mother	0.5	0.7	1.4	-0.9	-0.2	0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	7.0	-2.6	-0.9	1.8	2.3
Pulse wave Arterial Stiffness index	1.5	1.7	5.2	1.1	-0.4	-2.3	0.4
Impedance of arm (left)	0.6	3.0	4.8	2.2	1.8	-1.2	-1.6
Arm fat mass (right)	0.1	0.2	0.5	-0.7	0.2	0.7	0.0
Trunk predicted mass	0.5	2.8	5.5	-2.4	-1.9	0.9	1.1
Standing height	0.0	0.2	0.3	-0.5	-0.5	-0.2	-0.5
Length of working week for main job	1.4	1.5	2.9	-0.7	-0.0	1.7	1.6
Exposure to tobacco smoke at home	2.4	2.7	4.8	-2.2	-1.4	1.3	1.6
Breastfed as a baby	1.6	2.0	5.6	0.3	-1.4	-2.4	-0.5
Tense / ‘highly strung’	1.0	1.6	2.2	-1.4	-1.1	1.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.3	0.4	1.1	0.0
Hair/balding pattern: Pattern 4	0.4	1.0	2.7	0.9	0.4	-1.6	-0.5
Birth weight of first child	0.9	1.6	4.4	0.1	-2.1	-1.0	-0.9
Peak expiratory flow (PEF)	0.6	1.4	2.4	-1.5	0.6	0.9	1.5
Pulse wave reflection index	0.7	0.9	2.5	0.1	-0.1	-1.6	1.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.7	1.1	1.6	-0.8	-1.7
Loud music exposure frequency	0.7	0.8	1.0	-1.0	-0.8	1.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	-0.2	0.1	-0.5	-1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	-0.3	-0.8	0.9	1.4
Blood clot in the leg (DVT)	2.4	3.0	5.9	1.9	1.3	-1.1	-2.4
Medication: Paracetamol	0.4	0.6	1.3	0.2	1.1	0.2	1.0
Headache pain in last month	0.5	0.8	2.8	-0.6	-0.2	1.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	-0.6	-0.1	0.0	0.1
Glaucoma (self-reported)	0.4	0.5	1.8	0.3	1.3	0.4	-0.1
Gout (self-reported)	1.7	2.3	5.0	-1.6	-0.1	2.2	1.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.3	-0.6	0.6	0.1
Medication: Amlodipine	1.2	1.7	2.6	1.6	0.4	-1.2	-1.6
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.9	1.7	2.6	0.7	-1.4
Birth weight	2.0	4.3	6.8	-2.6	-2.2	1.9	1.4
Chronic bronchitis/emphysema (mother)	1.4	1.7	3.2	-1.6	-0.6	1.8	0.7
High blood pressure (siblings)	0.3	0.4	0.8	-0.9	-0.7	-0.1	0.5
Forced vital capacity (FVC), Best measure	1.0	3.8	6.0	-2.3	-0.8	2.4	1.8
Body fat percentage	0.1	0.3	0.9	0.3	0.9	-0.5	-0.2
Leg fat percentage (right)	0.1	0.3	0.8	-0.5	0.4	0.0	0.9
Arm fat-free mass (right)	0.3	1.7	3.6	-1.9	-1.6	0.1	0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.1	0.5	0.8	-0.5
Comparative body size at age 10	2.0	5.6	11.8	-3.4	0.2	3.0	1.1
Number of full brothers	3.7	4.6	7.9	-2.8	-1.1	1.9	2.3
Worry too long after embarrassment	1.0	1.6	4.1	-1.2	1.0	2.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	4.0	5.2	6.7	-2.6	-1.9	2.0	2.6
Wheeze or whistling in the chest in last year	1.0	1.8	3.2	1.2	1.8	0.1	-1.6
Number of children fathered	0.5	0.6	1.0	-0.9	0.7	1.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.2	-1.5	-1.2	0.9	1.2
Age at first live birth	0.7	1.2	3.8	-0.0	-1.0	-2.0	-0.0
Pulse wave peak to peak time	1.5	1.7	5.1	-1.2	0.4	2.3	-0.4
Health satisfaction	0.3	0.4	0.9	0.6	-0.3	-0.4	-0.9
Shortness of breath walking on level ground	0.7	0.8	1.7	0.8	0.5	-0.8	-1.3
Qualifications: College or University degree	0.7	2.3	4.1	1.3	0.7	-1.7	-2.0
Eye problems/disorders: None of the above	0.2	0.3	0.5	-0.7	-0.0	0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	-0.7	-0.4	0.9	-0.0
Emphysema/chronic bronchitis	1.5	1.7	3.8	1.5	0.8	-0.5	-1.9
Medication for pain relief, constipation, heartburn	1.4	2.4	5.2	-1.7	-2.3	0.5	1.1
Neck or shoulder pain in last month	1.4	2.0	3.2	1.5	1.8	0.5	-1.5
Medication: Blood pressure	0.2	0.4	0.7	0.9	0.2	-0.8	-0.1
Angina (self-reported)	1.0	1.3	2.5	1.4	1.6	-0.1	-0.9
Migraine (self-reported)	0.3	0.4	1.0	0.4	1.0	0.1	-0.7
Medication: Ibuprofen	0.7	0.8	2.1	0.0	1.5	1.0	-0.4
Medication: Allopurinol	1.0	1.3	2.5	-1.6	-0.2	1.5	0.7
Medication: Omeprazole	3.3	4.0	6.4	2.5	1.8	-0.9	-2.4
Medication: Seretide 50 evohaler	1.2	1.4	3.2	1.2	1.0	-0.1	-1.8
Mean time to correctly identify matches	0.9	1.6	3.1	1.8	-0.1	-1.3	-1.3
Heart disease (mother)	0.3	0.4	1.1	0.6	-0.0	-1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.8	-1.7	-1.0	0.9	0.9
Whole body fat mass	0.0	0.0	0.1	-0.3	0.3	-0.2	0.1
Leg fat mass (right)	0.2	0.7	1.3	-1.1	-0.4	0.4	1.1
Arm predicted mass (right)	0.3	1.6	3.3	-1.8	-1.5	0.2	0.8
Pulse rate, automated reading	0.4	1.3	4.3	0.5	-2.1	-0.7	0.2
Alcohol intake frequency.	0.3	0.7	2.6	-0.3	-0.3	1.6	-0.2
Comparative height size at age 10	0.1	0.3	1.1	0.1	0.4	-0.1	-1.1
Number of full sisters	1.5	1.9	2.2	-1.2	-1.4	1.5	1.3
Suffer from ‘nerves’	1.1	1.7	4.3	-1.1	-0.9	2.1	0.7
Overall health rating	0.2	0.4	1.1	0.5	0.5	1.1	-0.2
Chest pain or discomfort	2.5	3.6	8.1	1.4	2.9	0.6	-2.0
Had major operations	1.4	1.6	2.4	1.5	1.3	-0.4	-1.5
Age at last live birth	1.5	2.1	7.0	0.3	-0.6	-2.6	-1.0
Family relationship satisfaction	2.0	2.5	6.2	-1.7	-2.5	0.6	0.7
Leg pain on walking	0.4	0.5	1.4	-0.6	0.4	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	-0.5	-0.2	-0.4	-0.9
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.6	-1.6	-1.5	0.4	1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.7	0.2	1.0	0.6
Medication: Aspirin	1.3	1.8	2.6	1.5	0.4	-1.6	-1.4
Supplements: Vitamin C	1.0	1.1	1.5	-1.2	0.7	1.2	1.0
Knee pain experienced in last month	3.0	4.6	11.1	-2.4	-0.1	3.3	1.4
Hypertension (Self-reported)	0.3	0.9	2.0	1.4	0.4	-0.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	1.0	-0.1	-0.7	-0.6
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.3	-0.2	0.6	-0.4
Illnesses of siblings: Diabetes	2.1	2.6	5.4	-2.0	-0.5	0.8	2.3
Smoking status: Previous	0.1	0.2	0.4	0.4	0.7	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	-0.2	1.0	-0.2	-0.3
Whole body fat-free mass	0.4	2.3	4.5	-2.1	-1.8	0.9	0.9
Leg fat-free mass (right)	0.3	1.6	2.6	-1.6	-1.6	0.9	0.7
Arm fat percentage (left)	0.0	0.2	0.7	0.1	0.8	0.1	-0.1
Average weekly red wine intake	0.5	0.7	1.8	0.2	0.4	-1.4	-0.9
Handedness (chirality/laterality): Left-handed	2.5	3.0	4.7	-2.0	-2.2	1.0	1.5
Mood swings	1.1	2.0	4.6	-0.8	1.4	2.1	0.8
Loneliness, isolation	0.6	0.8	2.3	-0.7	-0.6	1.5	-0.3
Long-standing illness, disability or infirmity	1.6	2.4	4.2	1.9	1.4	0.2	-2.0
Ever had bowel cancer screening	1.0	1.2	3.6	0.4	-0.8	-1.9	-0.7
Diabetes diagnosed by doctor	0.6	1.0	1.3	1.1	-1.1	-0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.4	-1.2	-0.9	1.0	0.9
Friendships satisfaction	0.2	0.3	0.5	-0.3	-0.7	0.7	-0.0
Qualifications: nursing, teaching	1.7	2.6	3.3	1.8	0.8	-1.8	-1.8
Commuting to job workplace: Walk	1.1	1.2	2.0	1.2	0.3	-1.4	-1.2
Eye problems/disorders: Cataract	0.4	0.4	0.7	0.9	-0.6	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	-0.3	1.4	1.3	0.3
Medication for cholesterol	1.0	1.5	2.3	-1.5	0.7	1.1	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.0	0.7	1.0	-0.3
Back pain experienced in last month	0.4	0.6	1.3	0.8	1.2	0.6	-0.6
Mineral and other dietary supplements	0.2	0.2	0.4	-0.1	0.4	0.5	0.6
Breast cancer (self-reported)	0.2	0.3	0.8	0.9	-0.1	-0.1	-0.5
Asthma (self-reported)	0.5	1.0	1.5	1.1	1.1	0.3	-1.2
Osteoporosis (self-reported)	0.7	0.8	1.7	1.3	0.6	-1.0	-0.6
Osteoarthritis (self-reported)	0.5	0.7	1.1	0.7	1.0	0.1	-1.0
Medication: Aspirin	1.7	2.2	3.3	1.7	0.8	-1.4	-1.8
Medication: Gliclazide	0.3	0.3	1.1	0.4	-0.0	-1.0	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.3	-1.0	-1.1	1.1	0.4
Smoking status: Current	2.5	4.0	10.2	-2.1	0.6	3.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	5.1	-2.3	-1.9	0.4	1.8
Whole body water mass	0.4	2.2	4.4	-2.1	-1.8	0.8	0.8
Leg predicted mass (right)	0.3	1.7	2.8	-1.7	-1.7	0.9	0.7
Arm fat mass (left)	0.0	0.1	0.3	-0.5	0.0	0.2	-0.1
Number of self-reported non-cancer illnesses	1.9	3.2	7.0	2.6	0.1	-1.3	-2.0
Average weekly champagne plus white wine intake	1.6	2.2	6.6	1.2	-0.6	-2.6	-0.5
Miserableness	1.8	3.1	8.8	-1.6	0.5	3.0	0.8
Guilty feelings	0.3	0.5	1.3	-0.7	0.2	1.2	-0.4
Wears glasses or contact lenses	0.0	0.0	0.1	0.2	0.2	-0.0	-0.2
Ever taken oral contraceptive pill	1.7	1.9	4.8	0.7	2.2	0.4	-1.4
Hearing aid user	0.1	0.1	0.2	0.3	0.3	-0.2	-0.4
Mother’s age at death	0.8	1.1	1.5	1.2	-0.5	-1.1	-1.1
Financial situation satisfaction	0.8	1.0	2.5	-0.6	-1.6	0.8	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.3	-0.6	0.3	0.0
Commuting to job workplace: Public transport	0.6	0.7	1.2	-0.1	1.0	1.1	-0.6
Eye problems/disorders: Glaucoma	0.8	0.9	3.3	0.6	1.8	-0.3	-0.0
Medication: Blood pressure	0.7	1.3	2.8	1.7	0.9	-0.2	-1.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.0	0.3	0.3	2.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-0.0	-1.0	-0.9	0.1
High cholesterol (Self-reported)	0.3	0.6	1.0	0.8	-1.0	-0.3	-0.8
Medication: Bendroflumethiazide	1.9	2.9	4.9	1.6	1.4	-1.4	-2.2
Medication: Paracetamol	0.3	0.5	1.5	0.3	1.2	0.3	0.5
Medication: Lisinopril	1.5	1.9	3.4	1.5	-1.4	-1.8	-0.3
Medication: Atorvastatin	0.6	0.7	1.8	-0.5	-1.3	0.8	0.5
Illnesses of father: High blood pressure	0.3	0.3	0.6	0.8	0.6	-0.1	-0.6
Alcohol drinker status: Never	0.3	0.4	1.4	0.0	-1.2	-0.2	-0.2
Ever smoked	0.4	0.7	1.6	-0.5	0.7	1.3	-0.8
Basal metabolic rate	0.3	1.7	3.5	-1.9	-1.5	0.8	0.7
Leg fat percentage (left)	0.2	0.6	1.3	-0.6	0.6	0.5	1.1
Arm fat-free mass (left)	0.4	1.9	4.2	-2.0	-1.4	1.0	0.8
Number of operations (self-reported)	1.4	2.1	3.7	1.6	0.6	-1.3	-1.9
Average weekly beer plus cider intake	1.6	2.4	3.3	-1.8	-1.6	1.4	1.3
Irritability	1.0	1.6	4.1	-1.3	0.9	2.0	-0.0
Risk taking	1.5	2.2	4.5	-2.1	-0.3	2.0	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	0.6	-0.7	-0.9	-0.9
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.0	-0.2	-0.4	0.8
Age started oral contraceptive pill	1.1	1.4	2.7	1.2	-0.1	-1.6	-1.1
Diastolic blood pressure, automated reading	0.2	0.5	1.3	1.1	0.3	-0.8	0.3
Ever depressed for a whole week	0.6	0.8	1.6	0.2	1.1	0.5	-1.2
Unable to work because of sickness or disability	0.1	0.1	0.3	0.1	-0.5	-0.2	-0.1
Commuting to job workplace: Cycle	0.9	1.1	3.3	-0.0	-1.8	1.0	-0.0
Myopia	0.3	0.4	1.6	-0.1	-0.3	-1.2	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.1	-2.0	-0.7	1.0	1.1
Cholesterol lowering medication	1.1	1.7	2.3	1.4	-1.5	-1.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	4.2	5.1	6.9	2.6	2.5	-0.8	-2.6
Pain experienced in last month	1.1	1.9	4.3	0.4	-1.5	-2.1	-0.8
Supplements: Calcium	1.4	1.5	2.2	1.3	1.1	-0.9	-1.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.4	-1.0	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.5	0.5	0.7	1.0
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	5.3	2.0	1.6	-0.9	-2.3
Heart disease (siblings)	0.4	0.5	1.2	0.4	-1.1	0.2	0.8
Alcohol drinker status: Previous	0.3	0.4	1.1	0.3	-1.1	0.4	-0.0
Pack years of smoking	0.4	0.6	1.9	-0.4	0.3	1.4	0.4
Impedance of whole body	0.7	3.6	5.5	2.2	2.3	-1.3	-1.5
Leg fat mass (left)	0.2	0.9	1.5	-1.2	-0.2	0.7	1.2
Arm predicted mass (left)	0.3	1.6	3.7	-1.9	-1.4	0.7	0.6