Hub : Genes

SHROOM3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.6380 0.0810 2.0e-08 0.312 NA 0.376 NA 0.139 9.4e-09 NA 1.3e-10 NA 2.0e-04
2 GTEx Brain Cerebellum 0.5160 0.0780 8.1e-10 0.325 NA 0.425 NA 0.424 2.3e-10 NA 7.0e-14 NA 7.4e-14
3 GTEx Nerve Tibial 0.1493 0.0411 2.1e-05 0.068 NA 0.112 NA 0.093 1.5e-05 NA 2.7e-08 NA 4.1e-07
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0481 0.0206 2.2e-03 0.026 0.018 0.024 NA 0.018 6.3e-04 0.0032 9.0e-04 NA 3.7e-03
5 TCGA Prostate Adenocarcinoma 0.0798 0.0319 5.2e-04 0.017 0.016 0.014 NA 0.017 5.7e-03 0.0081 1.2e-02 NA 5.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.4 0.8 -0.4 0.4 0.6 -0.7 0.9
Bipolar Disorder or Schizophrenia 0.8 2.0 4.3 1.5 2.1 1.9 -0.4 0.0
Depressed Affect (Nagel 2018) 0.7 1.4 2.4 -1.2 -1.6 -1.2 1.2 -0.3
Depression (Nagel 2018) 1.5 2.3 4.5 1.7 1.8 2.1 -0.9 0.1
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.2 -0.6 -0.2 1.1 -1.1 1.1
Neuroticism (Nagel 2018) 0.5 1.2 2.3 -1.5 -1.5 -1.1 0.2 0.6
Schizophrenia (2018) 1.4 2.8 5.3 2.2 2.3 1.9 0.1 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.5 1.3 1.2 0.7 -0.1 0.5 -0.4
Worry (Nagel 2018) 0.1 0.1 0.2 -0.2 -0.5 0.0 -0.4 0.4
Alzheimer’s Disease (in mother) 0.8 1.0 1.7 0.4 0.8 1.1 -1.3 1.1
Alzheimer’s Disease (in father) 1.2 1.3 2.9 1.7 1.1 1.1 -1.0 0.5
Alzheimer’s Disease (including proxy) 1.5 2.2 5.6 0.3 0.8 0.8 -2.4 2.0
Crohns Disease (2017) 1.3 2.8 7.1 -0.6 0.1 -0.2 -2.5 2.7
Irritable Bowel Disease (IBD) 1.2 2.9 8.1 -0.2 0.6 0.4 -2.9 2.4
Ulcerative Colitis (UC) 0.5 0.9 2.3 0.5 0.7 0.8 -1.5 0.8
Major Depression (MDD) 0.3 0.4 0.8 -0.0 0.3 0.5 -0.9 0.8
Reaction Time 0.3 0.6 2.3 0.2 -0.1 0.5 1.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.8 -1.3 -0.6 0.0 -0.7 1.1
Breast Cancer 0.3 0.7 1.5 -0.6 -0.3 1.1 -0.8 1.2
Ovarian Cancer 5.3 7.0 12.9 3.4 3.0 3.6 -0.6 -1.1
Prostate Cancer 0.8 1.1 2.9 -0.2 0.3 -0.5 1.4 -1.7
Age at First Birth 0.9 1.3 2.8 1.1 0.8 0.1 -1.4 1.7
Bipolar Disorder (2011) 0.2 0.2 0.8 0.2 0.5 0.9 0.2 -0.1
Body Mass Index (BMI) (2010) 0.7 0.9 1.6 -0.9 -1.0 -0.3 0.9 -1.3
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.1 0.6 0.4 -0.3 0.0
Crohns Disease (2012) 0.4 0.6 1.6 0.0 -0.1 0.5 -1.1 1.3
Mean Putamen Volume 1.0 1.2 2.7 0.1 0.7 0.9 -1.4 1.6
Fasting Glucose 0.7 0.8 2.5 0.9 1.6 0.7 -0.2 0.5
HbA1C 0.7 0.7 1.4 1.0 0.2 0.5 1.0 -1.2
HDL Cholesterol 0.1 0.2 0.5 0.1 -0.6 0.7 0.3 0.2
LDL Cholesterol 1.1 1.8 3.2 -1.8 -1.6 -1.4 1.1 -0.4
Lupus 0.5 0.8 1.3 1.1 1.1 1.1 -0.0 -0.6
Neuroticism (2016) 0.6 0.9 1.4 -1.2 -1.1 -0.9 1.0 0.0
Primary Biliary Cirrhosis 1.1 1.6 2.8 1.0 1.7 1.1 -1.6 0.6
Rheumatoid Arthritis 0.4 0.6 2.3 -0.1 -0.1 -1.5 0.4 -0.5
Schizophrenia (2014) 1.0 2.3 4.5 2.1 1.9 0.9 0.9 -1.4
Triglycerides 0.2 0.4 0.7 0.8 0.9 0.0 -0.6 0.2
Type 2 Diabetes (T2D) (2012) 1.6 1.9 3.1 1.0 1.7 1.8 -1.4 0.8
Ulcerative Colitis 0.9 1.3 3.1 0.6 1.0 1.3 -1.8 0.4
Blood Eosinophil Count 0.3 2.1 4.5 -1.1 -2.1 -1.5 1.5 -0.2
Blood Platelet Count 0.4 4.1 6.4 2.5 1.5 2.5 1.5 -1.8
Blood Red Count 0.2 2.4 4.8 1.5 2.2 1.6 -1.5 0.3
Blood White Count 0.3 2.1 4.5 2.1 1.1 1.6 0.2 -1.5
Heel T-Score 0.1 0.7 1.2 0.8 -0.3 -0.5 1.1 -1.0
BMI 0.4 2.3 3.8 1.9 1.6 1.9 -0.2 -1.2
Height 0.4 7.8 17.8 -2.4 -4.2 -2.9 2.4 -1.3
Waist Hip Ratio (WHR) 0.1 0.3 0.9 -1.0 -0.5 -0.1 0.3 0.5
Systolic Blood Pressure 0.1 0.5 1.2 -0.6 -1.1 -0.0 -1.0 0.1
Smoking Status 1.3 3.2 5.4 -1.2 -2.3 -1.7 2.2 -1.2
Allergy or Eczema 1.1 2.9 8.9 -0.0 0.9 -0.2 -2.2 3.0
Cardiovascular Disease 0.3 1.1 1.8 -0.9 -1.1 -0.1 -1.4 1.2
Hypothyroidism (self reported) 0.8 1.8 3.4 1.8 0.6 0.7 1.6 -1.4
Respiratory disease 0.1 0.1 0.3 0.2 -0.2 0.6 -0.4 0.3
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.2 1.6 1.5 1.8 -0.7 -0.3
Lung FEV1/FVC ratio 0.7 3.6 6.6 2.0 2.6 2.3 0.2 -1.4
Lung FVC 4.4 22.2 37.3 -5.8 -6.1 -6.1 1.4 0.2
Neuroticism 0.8 1.9 4.5 -1.5 -2.1 -1.6 0.3 0.1
Chronotype (morning person) 0.2 0.5 1.4 -0.2 -0.6 0.2 1.2 -0.9
Hair Pigment 0.5 12.8 37.9 -0.7 1.8 1.5 -6.2 4.5
Tanning 0.1 1.6 3.5 1.5 0.4 0.3 1.4 -1.9
Hand grip strength (left) 1.4 3.8 7.3 -1.4 -2.5 -2.7 1.8 -0.0
Number of treatments/medications taken 0.5 0.8 1.4 1.2 1.0 1.0 0.0 -0.9
Average weekly spirits intake 0.3 0.3 1.2 -0.6 -0.3 0.1 0.4 -1.1
Sensitivity / hurt feelings 0.0 0.0 0.1 0.1 -0.1 0.0 -0.1 -0.2
Frequency of depressed mood in last 2 weeks 1.3 1.8 4.2 1.4 1.5 2.1 -0.6 -0.7
Hearing difficulty/problems: Yes 1.7 2.5 6.2 -0.4 -1.3 -0.7 2.5 -2.1
Relative age of first facial hair 0.5 0.9 2.2 -0.4 -0.9 -0.3 1.2 -1.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 -0.1 -0.0 0.3 0.8 -0.8
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.4 0.3 0.1 0.2 1.5 -2.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.4 0.4 0.7 0.2 -0.2
Systolic blood pressure, automated reading 0.3 0.7 1.5 -0.4 -0.9 0.5 -1.2 1.0
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 4.4 0.6 1.0 1.6 -2.1 1.9
Angina 0.4 0.5 1.6 -0.2 -0.5 0.1 0.7 -1.3
Medication for hormone replacement therapy 0.7 0.8 2.0 0.7 1.4 1.2 0.1 -0.3
Vitamin and mineral supplements 1.8 2.4 4.3 -2.1 -1.5 -1.3 -1.5 1.2
Supplements: Zinc 0.7 0.8 1.5 1.2 1.2 0.7 -0.4 0.6
Medication: Co-codamol 2.6 3.1 10.4 0.6 0.2 -0.2 2.1 -3.2
Medication: Metformin 0.7 1.0 2.3 1.2 0.5 1.5 0.2 -1.1
Diabetes (father) 0.4 0.5 1.2 0.3 1.1 0.4 0.1 -0.9
Diabetes (mother) 0.8 1.0 1.6 0.5 1.2 0.7 -1.3 1.2
Severe depression (siblings) 0.3 0.3 0.9 0.3 0.7 -0.2 0.9 -0.5
Pack years adult smoking proportion 3.2 4.8 10.5 -0.2 -1.3 -1.6 3.0 -3.2
Impedance of leg (right) 0.1 0.6 1.0 -0.8 0.0 -1.0 -0.9 0.8
Leg fat-free mass (left) 0.1 0.4 0.5 0.6 -0.7 0.6 0.6 -0.7
Trunk fat percentage 0.9 3.7 6.4 2.0 2.5 2.5 -1.3 -0.3
Hand grip strength (right) 1.4 3.9 7.1 -1.3 -2.5 -2.7 2.1 -0.0
Townsend deprivation index at recruitment 1.9 2.6 3.8 -2.0 -1.9 -1.7 1.6 -0.7
Current tobacco smoking 1.5 2.4 6.3 0.0 -1.5 -1.0 2.5 -1.6
Average weekly fortified wine intake 0.3 0.3 0.8 -0.1 -0.3 0.4 -0.9 0.7
Maternal smoking around birth 1.6 2.4 6.8 1.5 0.9 0.7 1.3 -2.6
Fed-up feelings 0.4 0.7 1.1 -1.0 -1.0 -0.8 0.8 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.7 1.6 2.2 1.7 -0.7 0.1
Relative age voice broke 1.9 2.9 5.8 -2.4 -1.7 -2.3 0.5 -0.4
Taking other prescription medications 1.6 2.4 4.8 1.7 2.2 1.7 -0.4 -1.2
Age when periods started (menarche) 0.2 0.4 1.3 0.5 0.0 -0.3 -1.1 0.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 3.0 1.7 1.2 1.6 0.4 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.8 0.3 0.0 -0.5 0.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.8 -0.3 -0.4 0.6 -0.8
Qualifications: CSEs or equivalent 0.2 0.3 1.0 0.2 0.2 -0.5 -1.0 0.4
Serious illness, injury or assault to yourself 0.2 0.3 0.7 0.3 0.8 0.3 0.1 -0.7
High blood pressure 0.0 0.1 0.2 -0.2 -0.4 0.3 -0.2 -0.3
Hayfever, allergic rhinitis or eczema 1.3 2.9 8.4 0.2 0.9 -0.4 -2.3 2.9
Multivitamins +/- minerals 1.6 2.0 4.0 2.0 1.4 1.2 1.3 -1.1
Stomach or abdominal pain in last month 0.8 1.0 3.1 -0.3 0.7 0.6 -1.8 0.8
Supplements: Glucosamine 1.6 2.1 4.9 2.2 1.5 0.3 1.4 -1.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 -0.6 -0.6 -1.1 0.8 -0.5
Medication: Atenolol 0.4 0.6 1.6 0.8 0.3 1.2 -0.6 -0.4
Medication: Levothyroxine sodium 1.4 2.4 5.2 0.6 -1.2 -0.7 2.3 -2.1
Sitting height 0.1 0.7 1.8 -0.5 -1.4 -0.2 -1.1 0.4
Chronic bronchitis/emphysema (father) 0.4 0.5 0.7 0.4 0.8 0.6 -0.7 0.7
High blood pressure (mother) 0.6 0.8 2.3 0.1 0.3 0.4 -1.3 1.5
Body mass index (BMI) 0.7 3.0 5.4 2.1 2.1 2.3 -0.3 -0.8
Impedance of leg (left) 0.1 0.4 0.6 -0.5 0.1 -0.8 -0.8 0.5
Leg predicted mass (left) 0.1 0.5 0.6 0.7 -0.7 0.7 0.6 -0.8
Trunk fat mass 0.6 2.4 4.9 1.8 1.8 2.2 -0.8 -0.6
Waist circumference 0.1 0.2 0.8 0.1 0.3 0.9 0.1 -0.3
Number of incorrect matches in round 1.2 2.1 4.3 2.1 1.6 0.8 1.4 -0.9
Past tobacco smoking 1.0 1.9 3.9 2.0 1.7 1.4 -0.8 0.4
Alcohol usually taken with meals 1.2 2.0 3.4 1.2 1.8 1.1 -1.8 0.8
Nervous feelings 0.6 1.1 2.4 -0.2 -0.6 -0.6 -1.5 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.8 0.5 1.2 0.8 -1.3 0.9
Hearing difficulty/problems with background noise 1.0 1.6 3.2 -0.8 -1.0 -1.0 1.8 -1.5
Hair/balding pattern: Pattern 2 0.4 0.5 1.4 0.7 0.5 -0.0 0.7 -1.2
Had menopause 1.1 1.3 2.4 0.7 0.5 1.3 1.5 -1.3
Had other major operations 3.5 4.3 8.8 2.2 1.9 1.0 1.8 -3.0
Forced vital capacity (FVC) 4.1 15.7 33.1 -4.6 -5.8 -4.7 0.5 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.3 0.3 0.1 -0.3 -0.8 1.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.2 0.2 -0.3 -0.1 0.5
Qualifications: None of the above 0.4 0.8 2.1 -0.7 -0.3 0.4 1.1 -1.4
Financial difficulties in last 2 years 1.2 1.6 3.0 -0.9 -1.2 -1.3 1.7 -1.1
Mouth/teeth dental problems 1.0 1.5 3.1 0.5 1.3 1.8 -1.3 0.7
Heart attack 0.2 0.2 0.8 0.2 -0.1 0.9 0.3 -0.6
Allergy 0.5 1.2 2.3 -0.5 -0.9 -0.5 1.5 -1.5
Pain all over the body in last month 1.2 1.3 2.5 1.6 0.9 1.6 0.0 -0.8
Diabetes (self-reported) 1.1 1.8 3.6 1.5 1.4 1.9 -0.8 -0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 -0.4 0.1 -0.2 -0.7 0.6
Medication: Ramipril 0.7 0.9 2.0 -0.1 -0.8 0.0 1.4 -1.4
Medication: Simvastatin 1.1 1.6 3.5 -0.9 -1.0 -0.4 1.9 -1.5
Fluid intelligence score 0.1 0.2 0.6 -0.5 -0.0 0.2 -0.8 0.5
Illnesses of siblings 0.3 0.5 0.9 0.9 0.1 -0.8 -0.8 0.1
Neuroticism score 0.1 0.3 0.6 0.1 -0.8 -0.4 0.4 -0.8
Weight 0.2 1.0 2.6 1.3 0.6 1.6 -0.1 -0.7
Impedance of arm (right) 0.1 0.4 1.2 -0.0 0.6 -0.1 -1.1 0.6
Arm fat percentage (right) 1.1 4.3 7.6 2.2 2.8 2.7 -0.9 -0.8
Trunk fat-free mass 0.2 1.0 2.9 0.0 -1.7 0.1 1.1 -1.1
Hip circumference 0.2 0.8 2.7 0.4 -0.2 0.4 1.0 -1.6
Time employed in main current job 0.3 0.3 0.7 0.1 0.6 0.0 0.7 -0.8
Alcohol intake versus 10 years previously 0.3 0.5 1.8 -0.1 0.0 -0.2 -0.8 1.4
Father’s age at death 0.4 0.5 1.1 0.5 -0.1 0.3 1.1 -1.0
Worrier / anxious feelings 0.1 0.2 0.4 0.4 0.0 0.6 -0.5 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.4 0.4 0.1 -0.4 -0.5
Falls in the last year 1.5 2.1 6.1 1.4 0.7 0.9 1.0 -2.5
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 -0.3 -0.2 -0.1 -0.7 0.6
Number of live births 0.6 0.8 1.9 -0.9 -1.4 -0.9 -0.4 0.7
Forced expiratory volume in 1-second (FEV1) 2.3 7.9 17.1 -3.2 -4.1 -3.2 -0.1 1.1
Pulse rate 2.4 4.1 5.7 -1.1 -1.7 -2.3 2.4 -2.3
Happiness 0.5 0.6 0.9 0.8 0.9 0.3 -0.9 0.9
Noisy workplace 0.7 0.9 3.1 -0.5 -0.2 -0.1 1.8 -1.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.5 -0.2 -0.6 0.3 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.7 -1.2 -0.3 -1.6 0.0 0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 3.0 0.1 -0.5 -0.5 1.7 -1.2
Asthma 0.1 0.2 0.6 -0.2 -0.2 0.3 -0.8 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.6 1.3 1.2 0.3 -0.9 0.9
Medication: Cholesterol lowering 1.0 1.5 4.3 0.1 -1.0 -0.6 1.4 -2.1
Depression (self-reported) 0.6 0.7 1.6 1.3 1.3 0.1 -0.3 -0.3
Medication: Lansoprazole 0.1 0.1 0.4 -0.2 -0.3 -0.6 -0.4 -0.1
Prospective memory result 0.5 0.6 0.9 0.2 0.8 0.8 0.8 -1.0
Lung cancer (father) 1.0 1.1 3.9 0.7 2.0 0.8 -0.6 0.5
Illnesses of mother 0.6 0.7 1.5 0.4 -0.2 -1.2 1.1 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.4 12.2 -2.7 -3.5 -2.7 0.5 0.3
Pulse wave Arterial Stiffness index 3.2 3.7 7.6 2.2 0.7 1.2 2.0 -2.8
Impedance of arm (left) 0.1 0.5 1.2 -0.3 0.4 -0.6 -1.1 0.8
Arm fat mass (right) 0.8 3.4 6.4 2.2 2.1 2.5 -0.5 -0.9
Trunk predicted mass 0.2 1.0 2.7 0.1 -1.6 0.1 1.1 -1.1
Standing height 0.3 3.3 12.0 -1.4 -3.5 -1.4 0.7 -0.2
Length of working week for main job 0.9 1.0 1.9 -0.2 -0.9 -0.8 1.3 -1.4
Exposure to tobacco smoke at home 2.9 3.3 7.0 -1.0 -1.4 -0.9 2.3 -2.6
Breastfed as a baby 1.2 1.5 4.2 -1.6 0.0 -0.2 -0.8 2.0
Tense / ‘highly strung’ 1.7 2.8 4.2 0.5 1.5 2.0 -2.0 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 4.1 1.7 2.0 1.0 -1.2 0.2
Hair/balding pattern: Pattern 4 0.5 1.2 2.4 -1.5 -1.6 -0.8 -0.1 0.8
Birth weight of first child 0.1 0.2 0.3 0.4 0.3 -0.4 0.4 -0.6
Peak expiratory flow (PEF) 0.4 1.0 2.9 -0.2 -0.3 0.1 -1.7 1.4
Pulse wave reflection index 1.5 1.9 4.3 1.6 1.1 2.1 -0.1 -1.0
Ever highly irritable/argumentative for 2 days 0.6 0.8 1.4 -1.2 -0.5 -0.5 -0.9 1.0
Loud music exposure frequency 0.4 0.4 0.9 0.9 0.7 0.2 0.0 -0.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 1.5 -0.9 -1.2 -1.2 0.8 -0.1
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.5 0.2 -0.5 -0.3 -0.1
Blood clot in the leg (DVT) 1.4 1.8 4.2 0.6 0.3 0.8 1.9 -2.0
Medication: Paracetamol 0.4 0.7 1.2 0.9 1.1 1.1 -0.0 -0.5
Headache pain in last month 0.8 1.4 3.4 0.2 0.2 -0.2 1.8 -1.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 0.3 0.9 0.8 -0.5 1.2
Glaucoma (self-reported) 0.2 0.2 0.4 0.1 -0.2 0.6 0.5 -0.6
Gout (self-reported) 0.4 0.5 1.5 0.5 0.5 0.4 -1.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.3 1.1 -0.2 0.7 1.1 -1.1
Medication: Amlodipine 0.5 0.6 1.2 -0.6 -1.1 -0.8 0.4 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.4 -1.2 -0.6 0.1 -1.0 0.9
Birth weight 0.8 1.7 4.2 -2.1 -1.2 -1.0 -0.8 1.2
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.3 -1.2 -0.1 -0.3 -0.6 -0.5
High blood pressure (siblings) 0.3 0.4 0.8 -0.8 -0.7 -0.3 0.9 0.3
Forced vital capacity (FVC), Best measure 3.1 11.3 22.9 -4.0 -4.8 -4.0 0.3 0.9
Body fat percentage 1.0 3.9 7.1 2.1 2.7 2.5 -1.1 -0.5
Leg fat percentage (right) 0.8 3.0 5.6 1.8 2.4 2.3 -0.6 -0.9
Arm fat-free mass (right) 0.1 0.7 1.0 0.6 -1.0 0.4 1.0 -1.0
Exposure to tobacco smoke outside home 3.1 4.1 9.2 1.8 3.0 1.7 -2.2 0.5
Comparative body size at age 10 0.7 1.9 5.3 2.3 0.9 0.4 1.5 -0.9
Number of full brothers 1.2 1.5 2.5 -1.6 -1.4 -1.6 0.7 0.2
Worry too long after embarrassment 0.2 0.4 0.7 0.8 0.3 0.9 -0.6 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.5 0.6 0.7 -0.1 -0.0 -0.5
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 -0.7 -0.4 -0.1 -0.7 -0.1
Number of children fathered 0.4 0.5 1.3 0.5 0.8 0.1 -1.1 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 -0.2 -0.9 0.3 -0.2 0.2
Age at first live birth 0.9 1.7 2.7 1.6 1.6 1.6 -0.6 0.1
Pulse wave peak to peak time 3.3 3.9 7.6 -2.3 -1.0 -1.3 -1.9 2.8
Health satisfaction 0.3 0.4 0.8 0.7 0.6 0.9 -0.3 0.0
Shortness of breath walking on level ground 0.5 0.6 3.0 -0.0 0.1 -0.3 0.1 -1.7
Qualifications: College or University degree 1.1 3.5 9.7 0.3 1.1 0.9 -2.4 3.1
Eye problems/disorders: None of the above 1.0 1.1 2.6 1.5 1.6 0.7 -0.5 -0.4
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 -0.6 0.0 -0.4 0.1 -0.4
Emphysema/chronic bronchitis 0.4 0.5 1.0 -0.8 -0.2 -0.4 0.8 -1.0
Medication for pain relief, constipation, heartburn 1.1 1.9 4.7 -1.9 -2.2 -0.9 0.9 0.1
Neck or shoulder pain in last month 0.2 0.2 0.6 -0.2 -0.3 -0.4 0.6 -0.7
Medication: Blood pressure 0.2 0.3 0.5 -0.5 -0.5 -0.7 0.0 -0.7
Angina (self-reported) 0.4 0.5 1.5 -0.2 -0.6 -0.1 0.7 -1.2
Migraine (self-reported) 2.2 2.7 5.5 2.2 2.3 1.6 -0.6 0.5
Medication: Ibuprofen 0.3 0.4 0.7 0.8 0.3 -0.4 -0.6 0.8
Medication: Allopurinol 0.2 0.2 0.5 -0.4 -0.7 -0.4 -0.4 0.0
Medication: Omeprazole 0.3 0.3 0.7 0.6 0.3 0.3 -0.8 0.6
Medication: Seretide 50 evohaler 0.4 0.5 1.0 0.8 0.4 1.0 -0.6 0.4
Mean time to correctly identify matches 0.9 1.7 3.4 0.7 1.3 1.9 1.5 -0.9
Heart disease (mother) 0.3 0.4 0.8 -0.7 -0.9 0.3 0.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.9 1.0 0.9 -0.0 1.4 -1.0
Whole body fat mass 0.5 2.3 3.9 1.8 1.8 2.0 -0.6 -0.7
Leg fat mass (right) 0.5 1.8 3.1 1.5 1.6 1.8 -0.3 -0.8
Arm predicted mass (right) 0.1 0.6 1.1 0.5 -1.0 0.4 0.9 -0.8
Pulse rate, automated reading 0.1 0.3 0.6 -0.8 -0.8 -0.6 -0.0 0.3
Alcohol intake frequency. 0.6 1.4 3.5 0.3 -0.4 0.3 1.9 -1.8
Comparative height size at age 10 0.5 2.8 7.9 -0.6 -2.8 -0.8 1.8 -1.4
Number of full sisters 0.7 0.8 1.8 -0.8 -0.7 -1.3 -0.5 0.9
Suffer from ‘nerves’ 0.1 0.2 0.4 -0.2 -0.2 0.1 -0.7 0.5
Overall health rating 0.4 0.8 1.6 0.6 1.3 1.1 -0.7 -0.5
Chest pain or discomfort 0.1 0.2 0.4 0.2 0.1 0.7 0.5 -0.6
Had major operations 1.1 1.3 2.5 1.2 1.1 1.6 -0.4 -1.1
Age at last live birth 0.4 0.6 1.3 -0.7 0.4 -0.3 -1.0 1.1
Family relationship satisfaction 0.7 0.9 1.2 -1.1 -0.7 -1.1 -0.8 0.9
Leg pain on walking 0.4 0.5 1.6 0.2 0.3 0.5 0.6 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.4 1.6 1.0 0.7 0.7 -1.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.8 0.7 -0.5 -0.8 1.0 -1.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.2 -0.6 -0.9 -0.1 -0.5 1.5
Medication: Aspirin 0.2 0.2 0.7 0.1 0.5 0.4 0.1 -0.8
Supplements: Vitamin C 0.6 0.7 2.1 -0.3 -0.5 -1.0 1.5 -0.3
Knee pain experienced in last month 0.3 0.4 0.7 0.6 0.8 0.9 -0.2 -0.5
Hypertension (Self-reported) 0.0 0.1 0.5 0.0 -0.2 0.3 -0.7 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.1 0.5 0.5 0.1 -1.0 0.7
Illnesses of father: Heart disease 4.8 6.6 13.6 -3.7 -2.7 -2.5 2.1 -1.2
Illnesses of siblings: Diabetes 1.1 1.4 3.6 0.4 0.5 0.7 1.6 -1.9
Smoking status: Previous 0.7 1.0 3.1 -1.8 -1.2 -0.6 0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.7 1.3 -0.0 0.6 0.3 -0.6
Whole body fat-free mass 0.1 0.8 1.4 0.5 -1.2 0.5 0.9 -1.1
Leg fat-free mass (right) 0.1 0.6 0.8 0.7 -0.8 0.6 0.7 -0.9
Arm fat percentage (left) 1.0 4.0 7.2 2.1 2.7 2.6 -1.1 -0.5
Average weekly red wine intake 0.7 1.1 2.4 -0.9 -0.4 0.6 -1.3 1.5
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.8 1.1 1.7 1.2 -1.3 0.2
Mood swings 0.2 0.4 0.9 -0.4 -0.5 -0.4 0.9 -0.7
Loneliness, isolation 0.4 0.5 1.4 0.6 0.0 0.5 0.8 -1.2
Long-standing illness, disability or infirmity 0.3 0.4 1.3 0.1 0.0 0.6 0.6 -1.2
Ever had bowel cancer screening 0.8 0.9 1.4 1.1 1.2 0.3 0.7 -1.2
Diabetes diagnosed by doctor 1.5 2.4 4.2 1.9 1.8 2.1 0.1 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.5 5.4 0.4 1.2 0.6 -2.3 2.3
Friendships satisfaction 2.1 2.6 4.3 1.8 2.1 1.7 -1.4 0.8
Qualifications: nursing, teaching 0.2 0.2 0.5 0.7 0.7 0.4 0.1 -0.2
Commuting to job workplace: Walk 2.0 2.2 4.4 -2.1 -0.3 -0.1 -1.6 2.0
Eye problems/disorders: Cataract 2.9 3.3 7.7 -2.8 -2.0 -1.5 0.5 1.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.0 -0.7 -1.7 -1.0 -0.0 0.7
Medication for cholesterol 0.4 0.6 2.5 -0.1 -0.6 -1.6 -0.2 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.5 1.0 1.2 0.5 -1.1 -0.3
Back pain experienced in last month 0.1 0.2 0.8 -0.9 -0.2 0.1 0.3 -0.2
Mineral and other dietary supplements 0.1 0.1 0.4 -0.4 -0.1 0.0 -0.0 -0.6
Breast cancer (self-reported) 0.2 0.2 1.1 -0.2 1.0 0.2 0.2 -0.1
Asthma (self-reported) 0.1 0.3 0.6 -0.3 -0.5 0.3 -0.8 0.6
Osteoporosis (self-reported) 2.1 2.6 3.6 1.6 1.6 1.9 -1.9 0.8
Osteoarthritis (self-reported) 0.7 0.9 2.9 -1.7 -0.8 -0.6 -0.3 0.7
Medication: Aspirin 0.1 0.1 0.4 -0.5 -0.0 0.1 0.1 -0.7
Medication: Gliclazide 0.6 0.6 1.8 -0.1 1.3 0.6 -1.0 0.3
Illnesses of father: None of the above (group 1) 0.3 0.4 1.5 1.2 0.2 0.2 0.2 -0.5
Smoking status: Current 1.3 2.1 4.2 -0.3 -1.4 -1.3 2.1 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 5.0 -1.7 -2.2 -1.6 0.6 -0.0
Whole body water mass 0.1 0.8 1.3 0.6 -1.1 0.5 0.9 -1.1
Leg predicted mass (right) 0.1 0.6 0.8 0.7 -0.8 0.6 0.7 -0.9
Arm fat mass (left) 0.7 3.0 5.4 2.1 1.9 2.3 -0.4 -1.0
Number of self-reported non-cancer illnesses 0.2 0.3 1.2 -0.2 0.1 0.1 0.5 -1.1
Average weekly champagne plus white wine intake 0.4 0.5 1.6 0.0 -0.0 -0.5 0.8 -1.2
Miserableness 0.6 1.1 2.7 -0.9 -1.6 -1.2 0.7 -0.1
Guilty feelings 0.9 1.4 3.0 1.3 1.2 0.8 -1.7 0.6
Wears glasses or contact lenses 0.3 0.4 0.6 0.7 0.8 0.7 0.4 -0.4
Ever taken oral contraceptive pill 1.8 2.0 4.6 0.2 0.6 0.7 -2.1 2.1
Hearing aid user 0.4 0.5 1.6 0.5 1.3 0.7 -0.4 -0.2
Mother’s age at death 1.0 1.2 3.0 -0.8 -0.0 -0.1 -1.7 1.6
Financial situation satisfaction 0.0 0.0 0.1 0.2 0.2 -0.0 0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 -0.2 -0.1 0.5 -0.0 0.1
Commuting to job workplace: Public transport 1.3 1.6 4.5 -0.2 0.7 0.4 -2.1 1.6
Eye problems/disorders: Glaucoma 1.0 1.2 2.7 -1.0 -1.6 0.0 1.0 -1.1
Medication: Blood pressure 0.2 0.3 1.3 0.1 0.1 1.1 -0.4 0.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.9 0.6 -0.1 0.9 1.4 -1.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.9 -1.0 -0.6 -0.9 -0.1 1.4
High cholesterol (Self-reported) 0.3 0.5 1.1 -1.0 -0.8 -0.1 0.6 -0.7
Medication: Bendroflumethiazide 0.6 0.9 2.3 -1.5 -1.0 -1.1 0.0 -0.1
Medication: Paracetamol 0.3 0.5 1.0 0.7 0.4 1.0 0.7 -0.5
Medication: Lisinopril 0.7 0.9 2.9 -1.7 -0.8 -0.2 -0.9 0.2
Medication: Atorvastatin 0.4 0.5 0.9 -0.9 -0.9 0.0 0.4 -0.8
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.4 -0.2 -0.3 -0.4 0.5
Alcohol drinker status: Never 2.0 2.3 4.3 -0.8 -1.4 -1.2 2.1 -1.9
Ever smoked 1.1 1.9 3.4 -1.5 -1.8 -1.1 1.2 -1.1
Basal metabolic rate 0.1 0.6 0.9 0.8 -0.6 0.8 0.6 -1.0
Leg fat percentage (left) 0.8 3.0 5.4 1.8 2.3 2.3 -0.5 -1.0
Arm fat-free mass (left) 0.2 0.9 1.6 0.8 -0.9 0.7 0.9 -1.3
Number of operations (self-reported) 1.6 2.4 6.8 1.4 0.5 0.3 1.6 -2.6
Average weekly beer plus cider intake 1.1 1.5 2.9 -0.8 -1.3 -1.3 0.9 -1.7
Irritability 0.5 0.9 1.8 -1.3 -1.1 -1.2 0.4 0.4
Risk taking 1.7 2.5 4.9 0.0 -1.3 -0.9 2.2 -2.2
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.4 0.7 1.0 0.1 -1.8 1.8
Fractured/broken bones in last 5 years 1.1 1.5 3.7 1.1 0.4 0.7 1.3 -1.9
Age started oral contraceptive pill 0.9 1.1 3.2 1.0 1.1 1.8 -0.2 0.5
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.1 -0.9 -0.2 -0.9 0.6
Ever depressed for a whole week 0.0 0.0 0.1 0.2 0.3 0.2 -0.1 -0.1
Unable to work because of sickness or disability 2.0 2.6 4.0 1.9 2.0 2.0 -0.4 -1.2
Commuting to job workplace: Cycle 0.0 0.1 0.1 0.1 0.3 0.0 -0.2 0.4
Myopia 1.1 1.6 3.5 1.3 0.5 0.6 1.6 -1.9
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.6 0.1 0.4 -0.3 -0.1 0.8
Cholesterol lowering medication 0.5 0.7 1.6 -0.7 -0.5 1.1 1.3 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.4 1.2 0.5 0.3 -0.3 0.1
Pain experienced in last month 0.1 0.2 0.4 -0.2 -0.6 -0.6 -0.2 0.4
Supplements: Calcium 0.3 0.3 0.6 0.3 0.3 0.4 0.7 -0.8
Basal cell carcinoma (self-reported) 0.5 0.7 1.4 -0.4 -0.6 -0.3 -1.2 1.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 -0.0 -0.2 0.8 0.4 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.8 0.6 0.5 1.0 1.9 -1.8
Heart disease (siblings) 0.4 0.5 1.3 -1.1 -0.3 0.6 0.1 0.9
Alcohol drinker status: Previous 0.5 0.6 1.0 -0.8 -0.6 -0.0 0.9 -1.0
Pack years of smoking 3.0 4.4 9.9 -0.1 -1.2 -1.5 2.9 -3.2
Impedance of whole body 0.1 0.6 1.4 -0.5 0.4 -0.7 -1.2 0.9
Leg fat mass (left) 0.5 1.9 3.5 1.6 1.7 1.9 -0.4 -0.8
Arm predicted mass (left) 0.2 1.0 2.0 0.7 -0.9 0.7 1.1 -1.4