TWAS hub - SHROOM3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.6380	0.0810	2.0e-08	0.312	NA	0.376	NA	0.139	9.4e-09	NA	1.3e-10	NA	2.0e-04
2	GTEx	Brain Cerebellum	0.5160	0.0780	8.1e-10	0.325	NA	0.425	NA	0.424	2.3e-10	NA	7.0e-14	NA	7.4e-14
3	GTEx	Nerve Tibial	0.1493	0.0411	2.1e-05	0.068	NA	0.112	NA	0.093	1.5e-05	NA	2.7e-08	NA	4.1e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0481	0.0206	2.2e-03	0.026	0.018	0.024	NA	0.018	6.3e-04	0.0032	9.0e-04	NA	3.7e-03
5	TCGA	Prostate Adenocarcinoma	0.0798	0.0319	5.2e-04	0.017	0.016	0.014	NA	0.017	5.7e-03	0.0081	1.2e-02	NA	5.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Ovarian Cancer	5.3	7.0	12.9	3.4	3.0	3.6	-0.6	-1.1
Illnesses of father: Heart disease	4.8	6.6	13.6	-3.7	-2.7	-2.5	2.1	-1.2
Lung FVC	4.4	22.2	37.3	-5.8	-6.1	-6.1	1.4	0.2
Forced vital capacity (FVC)	4.1	15.7	33.1	-4.6	-5.8	-4.7	0.5	1.2
Had other major operations	3.5	4.3	8.8	2.2	1.9	1.0	1.8	-3.0
Pulse wave peak to peak time	3.3	3.9	7.6	-2.3	-1.0	-1.3	-1.9	2.8
Pack years adult smoking proportion	3.2	4.8	10.5	-0.2	-1.3	-1.6	3.0	-3.2
Pulse wave Arterial Stiffness index	3.2	3.7	7.6	2.2	0.7	1.2	2.0	-2.8
Forced vital capacity (FVC), Best measure	3.1	11.3	22.9	-4.0	-4.8	-4.0	0.3	0.9
Exposure to tobacco smoke outside home	3.1	4.1	9.2	1.8	3.0	1.7	-2.2	0.5
Pack years of smoking	3.0	4.4	9.9	-0.1	-1.2	-1.5	2.9	-3.2
Exposure to tobacco smoke at home	2.9	3.3	7.0	-1.0	-1.4	-0.9	2.3	-2.6
Eye problems/disorders: Cataract	2.9	3.3	7.7	-2.8	-2.0	-1.5	0.5	1.5
Medication: Co-codamol	2.6	3.1	10.4	0.6	0.2	-0.2	2.1	-3.2
Pulse rate	2.4	4.1	5.7	-1.1	-1.7	-2.3	2.4	-2.3
Forced expiratory volume in 1-second (FEV1)	2.3	7.9	17.1	-3.2	-4.1	-3.2	-0.1	1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	5.4	0.4	1.2	0.6	-2.3	2.3
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	4.4	0.6	1.0	1.6	-2.1	1.9
Migraine (self-reported)	2.2	2.7	5.5	2.2	2.3	1.6	-0.6	0.5
Friendships satisfaction	2.1	2.6	4.3	1.8	2.1	1.7	-1.4	0.8
Osteoporosis (self-reported)	2.1	2.6	3.6	1.6	1.6	1.9	-1.9	0.8
Commuting to job workplace: Walk	2.0	2.2	4.4	-2.1	-0.3	-0.1	-1.6	2.0
Alcohol drinker status: Never	2.0	2.3	4.3	-0.8	-1.4	-1.2	2.1	-1.9
Unable to work because of sickness or disability	2.0	2.6	4.0	1.9	2.0	2.0	-0.4	-1.2
Townsend deprivation index at recruitment	1.9	2.6	3.8	-2.0	-1.9	-1.7	1.6	-0.7
Relative age voice broke	1.9	2.9	5.8	-2.4	-1.7	-2.3	0.5	-0.4
Vitamin and mineral supplements	1.8	2.4	4.3	-2.1	-1.5	-1.3	-1.5	1.2
Ever taken oral contraceptive pill	1.8	2.0	4.6	0.2	0.6	0.7	-2.1	2.1
Hearing difficulty/problems: Yes	1.7	2.5	6.2	-0.4	-1.3	-0.7	2.5	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	12.2	-2.7	-3.5	-2.7	0.5	0.3
Tense / ‘highly strung’	1.7	2.8	4.2	0.5	1.5	2.0	-2.0	1.9
Risk taking	1.7	2.5	4.9	0.0	-1.3	-0.9	2.2	-2.2
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.1	1.0	1.7	1.8	-1.4	0.8
Maternal smoking around birth	1.6	2.4	6.8	1.5	0.9	0.7	1.3	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.7	1.6	2.2	1.7	-0.7	0.1
Taking other prescription medications	1.6	2.4	4.8	1.7	2.2	1.7	-0.4	-1.2
Multivitamins +/- minerals	1.6	2.0	4.0	2.0	1.4	1.2	1.3	-1.1
Supplements: Glucosamine	1.6	2.1	4.9	2.2	1.5	0.3	1.4	-1.1
Number of operations (self-reported)	1.6	2.4	6.8	1.4	0.5	0.3	1.6	-2.6
Depression (Nagel 2018)	1.5	2.3	4.5	1.7	1.8	2.1	-0.9	0.1
Alzheimer’s Disease (including proxy)	1.5	2.2	5.6	0.3	0.8	0.8	-2.4	2.0
Current tobacco smoking	1.5	2.4	6.3	0.0	-1.5	-1.0	2.5	-1.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.0	1.7	1.2	1.6	0.4	-1.3
Falls in the last year	1.5	2.1	6.1	1.4	0.7	0.9	1.0	-2.5
Pulse wave reflection index	1.5	1.9	4.3	1.6	1.1	2.1	-0.1	-1.0
Diabetes diagnosed by doctor	1.5	2.4	4.2	1.9	1.8	2.1	0.1	-0.9
Schizophrenia (2018)	1.4	2.8	5.3	2.2	2.3	1.9	0.1	-0.7
Hand grip strength (left)	1.4	3.8	7.3	-1.4	-2.5	-2.7	1.8	-0.0
Hand grip strength (right)	1.4	3.9	7.1	-1.3	-2.5	-2.7	2.1	-0.0
Medication: Levothyroxine sodium	1.4	2.4	5.2	0.6	-1.2	-0.7	2.3	-2.1
Blood clot in the leg (DVT)	1.4	1.8	4.2	0.6	0.3	0.8	1.9	-2.0
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.4	0.7	1.0	0.1	-1.8	1.8
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.8	0.6	0.5	1.0	1.9	-1.8
Crohns Disease (2017)	1.3	2.8	7.1	-0.6	0.1	-0.2	-2.5	2.7
Smoking Status	1.3	3.2	5.4	-1.2	-2.3	-1.7	2.2	-1.2
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.2	1.4	1.5	2.1	-0.6	-0.7
Hayfever, allergic rhinitis or eczema	1.3	2.9	8.4	0.2	0.9	-0.4	-2.3	2.9
Smoking status: Current	1.3	2.1	4.2	-0.3	-1.4	-1.3	2.1	-1.6
Commuting to job workplace: Public transport	1.3	1.6	4.5	-0.2	0.7	0.4	-2.1	1.6
Alzheimer’s Disease (in father)	1.2	1.3	2.9	1.7	1.1	1.1	-1.0	0.5
Irritable Bowel Disease (IBD)	1.2	2.9	8.1	-0.2	0.6	0.4	-2.9	2.4
Number of incorrect matches in round	1.2	2.1	4.3	2.1	1.6	0.8	1.4	-0.9
Alcohol usually taken with meals	1.2	2.0	3.4	1.2	1.8	1.1	-1.8	0.8
Financial difficulties in last 2 years	1.2	1.6	3.0	-0.9	-1.2	-1.3	1.7	-1.1
Pain all over the body in last month	1.2	1.3	2.5	1.6	0.9	1.6	0.0	-0.8
Breastfed as a baby	1.2	1.5	4.2	-1.6	0.0	-0.2	-0.8	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.1	1.7	2.0	1.0	-1.2	0.2
Number of full brothers	1.2	1.5	2.5	-1.6	-1.4	-1.6	0.7	0.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.8	1.1	1.7	1.2	-1.3	0.2
LDL Cholesterol	1.1	1.8	3.2	-1.8	-1.6	-1.4	1.1	-0.4
Primary Biliary Cirrhosis	1.1	1.6	2.8	1.0	1.7	1.1	-1.6	0.6
Allergy or Eczema	1.1	2.9	8.9	-0.0	0.9	-0.2	-2.2	3.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.4	0.3	0.1	0.2	1.5	-2.1
Had menopause	1.1	1.3	2.4	0.7	0.5	1.3	1.5	-1.3
Diabetes (self-reported)	1.1	1.8	3.6	1.5	1.4	1.9	-0.8	-0.4
Medication: Simvastatin	1.1	1.6	3.5	-0.9	-1.0	-0.4	1.9	-1.5
Arm fat percentage (right)	1.1	4.3	7.6	2.2	2.8	2.7	-0.9	-0.8
Qualifications: College or University degree	1.1	3.5	9.7	0.3	1.1	0.9	-2.4	3.1
Medication for pain relief, constipation, heartburn	1.1	1.9	4.7	-1.9	-2.2	-0.9	0.9	0.1
Had major operations	1.1	1.3	2.5	1.2	1.1	1.6	-0.4	-1.1
Illnesses of siblings: Diabetes	1.1	1.4	3.6	0.4	0.5	0.7	1.6	-1.9
Ever smoked	1.1	1.9	3.4	-1.5	-1.8	-1.1	1.2	-1.1
Average weekly beer plus cider intake	1.1	1.5	2.9	-0.8	-1.3	-1.3	0.9	-1.7
Fractured/broken bones in last 5 years	1.1	1.5	3.7	1.1	0.4	0.7	1.3	-1.9
Myopia	1.1	1.6	3.5	1.3	0.5	0.6	1.6	-1.9
Mean Putamen Volume	1.0	1.2	2.7	0.1	0.7	0.9	-1.4	1.6
Schizophrenia (2014)	1.0	2.3	4.5	2.1	1.9	0.9	0.9	-1.4
Past tobacco smoking	1.0	1.9	3.9	2.0	1.7	1.4	-0.8	0.4
Hearing difficulty/problems with background noise	1.0	1.6	3.2	-0.8	-1.0	-1.0	1.8	-1.5
Mouth/teeth dental problems	1.0	1.5	3.1	0.5	1.3	1.8	-1.3	0.7
Medication: Cholesterol lowering	1.0	1.5	4.3	0.1	-1.0	-0.6	1.4	-2.1
Lung cancer (father)	1.0	1.1	3.9	0.7	2.0	0.8	-0.6	0.5
Body fat percentage	1.0	3.9	7.1	2.1	2.7	2.5	-1.1	-0.5
Eye problems/disorders: None of the above	1.0	1.1	2.6	1.5	1.6	0.7	-0.5	-0.4
Arm fat percentage (left)	1.0	4.0	7.2	2.1	2.7	2.6	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.0	-1.7	-2.2	-1.6	0.6	-0.0
Mother’s age at death	1.0	1.2	3.0	-0.8	-0.0	-0.1	-1.7	1.6
Eye problems/disorders: Glaucoma	1.0	1.2	2.7	-1.0	-1.6	0.0	1.0	-1.1
Age at First Birth	0.9	1.3	2.8	1.1	0.8	0.1	-1.4	1.7
Ulcerative Colitis	0.9	1.3	3.1	0.6	1.0	1.3	-1.8	0.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.2	1.6	1.5	1.8	-0.7	-0.3
Trunk fat percentage	0.9	3.7	6.4	2.0	2.5	2.5	-1.3	-0.3
Length of working week for main job	0.9	1.0	1.9	-0.2	-0.9	-0.8	1.3	-1.4
Age at first live birth	0.9	1.7	2.7	1.6	1.6	1.6	-0.6	0.1
Mean time to correctly identify matches	0.9	1.7	3.4	0.7	1.3	1.9	1.5	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	1.6	1.0	0.7	0.7	-1.0
Guilty feelings	0.9	1.4	3.0	1.3	1.2	0.8	-1.7	0.6
Age started oral contraceptive pill	0.9	1.1	3.2	1.0	1.1	1.8	-0.2	0.5
Bipolar Disorder or Schizophrenia	0.8	2.0	4.3	1.5	2.1	1.9	-0.4	0.0
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	0.4	0.8	1.1	-1.3	1.1
Prostate Cancer	0.8	1.1	2.9	-0.2	0.3	-0.5	1.4	-1.7
Hypothyroidism (self reported)	0.8	1.8	3.4	1.8	0.6	0.7	1.6	-1.4
Neuroticism	0.8	1.9	4.5	-1.5	-2.1	-1.6	0.3	0.1
Diabetes (mother)	0.8	1.0	1.6	0.5	1.2	0.7	-1.3	1.2
Stomach or abdominal pain in last month	0.8	1.0	3.1	-0.3	0.7	0.6	-1.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.7	-1.2	-0.3	-1.6	0.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	1.3	1.2	0.3	-0.9	0.9
Arm fat mass (right)	0.8	3.4	6.4	2.2	2.1	2.5	-0.5	-0.9
Headache pain in last month	0.8	1.4	3.4	0.2	0.2	-0.2	1.8	-1.8
Birth weight	0.8	1.7	4.2	-2.1	-1.2	-1.0	-0.8	1.2
Leg fat percentage (right)	0.8	3.0	5.6	1.8	2.4	2.3	-0.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	1.0	0.9	-0.0	1.4	-1.0
Ever had bowel cancer screening	0.8	0.9	1.4	1.1	1.2	0.3	0.7	-1.2
Leg fat percentage (left)	0.8	3.0	5.4	1.8	2.3	2.3	-0.5	-1.0
Depressed Affect (Nagel 2018)	0.7	1.4	2.4	-1.2	-1.6	-1.2	1.2	-0.3
Body Mass Index (BMI) (2010)	0.7	0.9	1.6	-0.9	-1.0	-0.3	0.9	-1.3
Fasting Glucose	0.7	0.8	2.5	0.9	1.6	0.7	-0.2	0.5
HbA1C	0.7	0.7	1.4	1.0	0.2	0.5	1.0	-1.2
Lung FEV1/FVC ratio	0.7	3.6	6.6	2.0	2.6	2.3	0.2	-1.4
Medication for hormone replacement therapy	0.7	0.8	2.0	0.7	1.4	1.2	0.1	-0.3
Supplements: Zinc	0.7	0.8	1.5	1.2	1.2	0.7	-0.4	0.6
Medication: Metformin	0.7	1.0	2.3	1.2	0.5	1.5	0.2	-1.1
Body mass index (BMI)	0.7	3.0	5.4	2.1	2.1	2.3	-0.3	-0.8
Medication: Ramipril	0.7	0.9	2.0	-0.1	-0.8	0.0	1.4	-1.4
Noisy workplace	0.7	0.9	3.1	-0.5	-0.2	-0.1	1.8	-1.0
Comparative body size at age 10	0.7	1.9	5.3	2.3	0.9	0.4	1.5	-0.9
Number of full sisters	0.7	0.8	1.8	-0.8	-0.7	-1.3	-0.5	0.9
Family relationship satisfaction	0.7	0.9	1.2	-1.1	-0.7	-1.1	-0.8	0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	0.7	-0.5	-0.8	1.0	-1.3
Smoking status: Previous	0.7	1.0	3.1	-1.8	-1.2	-0.6	0.1	0.4
Average weekly red wine intake	0.7	1.1	2.4	-0.9	-0.4	0.6	-1.3	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	1.0	1.2	0.5	-1.1	-0.3
Osteoarthritis (self-reported)	0.7	0.9	2.9	-1.7	-0.8	-0.6	-0.3	0.7
Arm fat mass (left)	0.7	3.0	5.4	2.1	1.9	2.3	-0.4	-1.0
Medication: Lisinopril	0.7	0.9	2.9	-1.7	-0.8	-0.2	-0.9	0.2
Neuroticism (2016)	0.6	0.9	1.4	-1.2	-1.1	-0.9	1.0	0.0
High blood pressure (mother)	0.6	0.8	2.3	0.1	0.3	0.4	-1.3	1.5
Trunk fat mass	0.6	2.4	4.9	1.8	1.8	2.2	-0.8	-0.6
Nervous feelings	0.6	1.1	2.4	-0.2	-0.6	-0.6	-1.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.8	0.5	1.2	0.8	-1.3	0.9
Number of live births	0.6	0.8	1.9	-0.9	-1.4	-0.9	-0.4	0.7
Mouth/teeth dental problems: Dentures	0.6	1.0	3.0	0.1	-0.5	-0.5	1.7	-1.2
Depression (self-reported)	0.6	0.7	1.6	1.3	1.3	0.1	-0.3	-0.3
Illnesses of mother	0.6	0.7	1.5	0.4	-0.2	-1.2	1.1	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.4	-1.2	-0.5	-0.5	-0.9	1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	-1.2	-0.6	0.1	-1.0	0.9
Alcohol intake frequency.	0.6	1.4	3.5	0.3	-0.4	0.3	1.9	-1.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.2	-0.6	-0.9	-0.1	-0.5	1.5
Supplements: Vitamin C	0.6	0.7	2.1	-0.3	-0.5	-1.0	1.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.0	-0.7	-1.7	-1.0	-0.0	0.7
Medication: Gliclazide	0.6	0.6	1.8	-0.1	1.3	0.6	-1.0	0.3
Miserableness	0.6	1.1	2.7	-0.9	-1.6	-1.2	0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	0.6	-0.1	0.9	1.4	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.9	-1.0	-0.6	-0.9	-0.1	1.4
Medication: Bendroflumethiazide	0.6	0.9	2.3	-1.5	-1.0	-1.1	0.0	-0.1
Neuroticism (Nagel 2018)	0.5	1.2	2.3	-1.5	-1.5	-1.1	0.2	0.6
Ulcerative Colitis (UC)	0.5	0.9	2.3	0.5	0.7	0.8	-1.5	0.8
Lupus	0.5	0.8	1.3	1.1	1.1	1.1	-0.0	-0.6
Hair Pigment	0.5	12.8	37.9	-0.7	1.8	1.5	-6.2	4.5
Number of treatments/medications taken	0.5	0.8	1.4	1.2	1.0	1.0	0.0	-0.9
Relative age of first facial hair	0.5	0.9	2.2	-0.4	-0.9	-0.3	1.2	-1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.6	-0.6	-1.1	0.8	-0.5
Allergy	0.5	1.2	2.3	-0.5	-0.9	-0.5	1.5	-1.5
Happiness	0.5	0.6	0.9	0.8	0.9	0.3	-0.9	0.9
Prospective memory result	0.5	0.6	0.9	0.2	0.8	0.8	0.8	-1.0
Hair/balding pattern: Pattern 4	0.5	1.2	2.4	-1.5	-1.6	-0.8	-0.1	0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.5	-0.9	-1.2	-1.2	0.8	-0.1
Medication: Amlodipine	0.5	0.6	1.2	-0.6	-1.1	-0.8	0.4	-0.9
Shortness of breath walking on level ground	0.5	0.6	3.0	-0.0	0.1	-0.3	0.1	-1.7
Whole body fat mass	0.5	2.3	3.9	1.8	1.8	2.0	-0.6	-0.7
Leg fat mass (right)	0.5	1.8	3.1	1.5	1.6	1.8	-0.3	-0.8
Comparative height size at age 10	0.5	2.8	7.9	-0.6	-2.8	-0.8	1.8	-1.4
Irritability	0.5	0.9	1.8	-1.3	-1.1	-1.2	0.4	0.4
Cholesterol lowering medication	0.5	0.7	1.6	-0.7	-0.5	1.1	1.3	-0.3
Basal cell carcinoma (self-reported)	0.5	0.7	1.4	-0.4	-0.6	-0.3	-1.2	1.1
Alcohol drinker status: Previous	0.5	0.6	1.0	-0.8	-0.6	-0.0	0.9	-1.0
Leg fat mass (left)	0.5	1.9	3.5	1.6	1.7	1.9	-0.4	-0.8
Crohns Disease (2012)	0.4	0.6	1.6	0.0	-0.1	0.5	-1.1	1.3
Rheumatoid Arthritis	0.4	0.6	2.3	-0.1	-0.1	-1.5	0.4	-0.5
Blood Platelet Count	0.4	4.1	6.4	2.5	1.5	2.5	1.5	-1.8
BMI	0.4	2.3	3.8	1.9	1.6	1.9	-0.2	-1.2
Height	0.4	7.8	17.8	-2.4	-4.2	-2.9	2.4	-1.3
Angina	0.4	0.5	1.6	-0.2	-0.5	0.1	0.7	-1.3
Diabetes (father)	0.4	0.5	1.2	0.3	1.1	0.4	0.1	-0.9
Fed-up feelings	0.4	0.7	1.1	-1.0	-1.0	-0.8	0.8	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	-0.3	-0.4	0.6	-0.8
Medication: Atenolol	0.4	0.6	1.6	0.8	0.3	1.2	-0.6	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.4	0.8	0.6	-0.7	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	0.7	0.5	-0.0	0.7	-1.2
Qualifications: None of the above	0.4	0.8	2.1	-0.7	-0.3	0.4	1.1	-1.4
Father’s age at death	0.4	0.5	1.1	0.5	-0.1	0.3	1.1	-1.0
Peak expiratory flow (PEF)	0.4	1.0	2.9	-0.2	-0.3	0.1	-1.7	1.4
Loud music exposure frequency	0.4	0.4	0.9	0.9	0.7	0.2	0.0	-0.9
Medication: Paracetamol	0.4	0.7	1.2	0.9	1.1	1.1	-0.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	0.3	0.9	0.8	-0.5	1.2
Gout (self-reported)	0.4	0.5	1.5	0.5	0.5	0.4	-1.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.3	1.1	-0.2	0.7	1.1	-1.1
Number of children fathered	0.4	0.5	1.3	0.5	0.8	0.1	-1.1	0.5
Emphysema/chronic bronchitis	0.4	0.5	1.0	-0.8	-0.2	-0.4	0.8	-1.0
Angina (self-reported)	0.4	0.5	1.5	-0.2	-0.6	-0.1	0.7	-1.2
Medication: Seretide 50 evohaler	0.4	0.5	1.0	0.8	0.4	1.0	-0.6	0.4
Overall health rating	0.4	0.8	1.6	0.6	1.3	1.1	-0.7	-0.5
Age at last live birth	0.4	0.6	1.3	-0.7	0.4	-0.3	-1.0	1.1
Leg pain on walking	0.4	0.5	1.6	0.2	0.3	0.5	0.6	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	0.5	0.5	0.1	-1.0	0.7
Loneliness, isolation	0.4	0.5	1.4	0.6	0.0	0.5	0.8	-1.2
Medication for cholesterol	0.4	0.6	2.5	-0.1	-0.6	-1.6	-0.2	0.0
Average weekly champagne plus white wine intake	0.4	0.5	1.6	0.0	-0.0	-0.5	0.8	-1.2
Hearing aid user	0.4	0.5	1.6	0.5	1.3	0.7	-0.4	-0.2
Medication: Atorvastatin	0.4	0.5	0.9	-0.9	-0.9	0.0	0.4	-0.8
Heart disease (siblings)	0.4	0.5	1.3	-1.1	-0.3	0.6	0.1	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.2	-0.6	-0.2	1.1	-1.1	1.1
Schizophrenia vs Biploar Disorder	0.3	0.5	1.3	1.2	0.7	-0.1	0.5	-0.4
Major Depression (MDD)	0.3	0.4	0.8	-0.0	0.3	0.5	-0.9	0.8
Reaction Time	0.3	0.6	2.3	0.2	-0.1	0.5	1.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.8	-1.3	-0.6	0.0	-0.7	1.1
Breast Cancer	0.3	0.7	1.5	-0.6	-0.3	1.1	-0.8	1.2
Blood Eosinophil Count	0.3	2.1	4.5	-1.1	-2.1	-1.5	1.5	-0.2
Blood White Count	0.3	2.1	4.5	2.1	1.1	1.6	0.2	-1.5
Cardiovascular Disease	0.3	1.1	1.8	-0.9	-1.1	-0.1	-1.4	1.2
Average weekly spirits intake	0.3	0.3	1.2	-0.6	-0.3	0.1	0.4	-1.1
Systolic blood pressure, automated reading	0.3	0.7	1.5	-0.4	-0.9	0.5	-1.2	1.0
Severe depression (siblings)	0.3	0.3	0.9	0.3	0.7	-0.2	0.9	-0.5
Average weekly fortified wine intake	0.3	0.3	0.8	-0.1	-0.3	0.4	-0.9	0.7
Illnesses of siblings	0.3	0.5	0.9	0.9	0.1	-0.8	-0.8	0.1
Time employed in main current job	0.3	0.3	0.7	0.1	0.6	0.0	0.7	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.8	-0.1	0.0	-0.2	-0.8	1.4
Standing height	0.3	3.3	12.0	-1.4	-3.5	-1.4	0.7	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.3	-1.2	-0.1	-0.3	-0.6	-0.5
High blood pressure (siblings)	0.3	0.4	0.8	-0.8	-0.7	-0.3	0.9	0.3
Health satisfaction	0.3	0.4	0.8	0.7	0.6	0.9	-0.3	0.0
Medication: Ibuprofen	0.3	0.4	0.7	0.8	0.3	-0.4	-0.6	0.8
Medication: Omeprazole	0.3	0.3	0.7	0.6	0.3	0.3	-0.8	0.6
Heart disease (mother)	0.3	0.4	0.8	-0.7	-0.9	0.3	0.4	-0.7
Knee pain experienced in last month	0.3	0.4	0.7	0.6	0.8	0.9	-0.2	-0.5
Long-standing illness, disability or infirmity	0.3	0.4	1.3	0.1	0.0	0.6	0.6	-1.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	1.2	0.2	0.2	0.2	-0.5
Wears glasses or contact lenses	0.3	0.4	0.6	0.7	0.8	0.7	0.4	-0.4
High cholesterol (Self-reported)	0.3	0.5	1.1	-1.0	-0.8	-0.1	0.6	-0.7
Medication: Paracetamol	0.3	0.5	1.0	0.7	0.4	1.0	0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.4	1.2	0.5	0.3	-0.3	0.1
Supplements: Calcium	0.3	0.3	0.6	0.3	0.3	0.4	0.7	-0.8
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.4	0.4	0.6	-0.7	0.9
Bipolar Disorder (2011)	0.2	0.2	0.8	0.2	0.5	0.9	0.2	-0.1
Triglycerides	0.2	0.4	0.7	0.8	0.9	0.0	-0.6	0.2
Blood Red Count	0.2	2.4	4.8	1.5	2.2	1.6	-1.5	0.3
Chronotype (morning person)	0.2	0.5	1.4	-0.2	-0.6	0.2	1.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.1	-0.0	0.3	0.8	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.4	0.4	0.7	0.2	-0.2
Age when periods started (menarche)	0.2	0.4	1.3	0.5	0.0	-0.3	-1.1	0.7
Qualifications: CSEs or equivalent	0.2	0.3	1.0	0.2	0.2	-0.5	-1.0	0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.3	0.8	0.3	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	0.3	0.1	-0.3	-0.8	1.1
Heart attack	0.2	0.2	0.8	0.2	-0.1	0.9	0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.4	0.1	-0.2	-0.7	0.6
Weight	0.2	1.0	2.6	1.3	0.6	1.6	-0.1	-0.7
Trunk fat-free mass	0.2	1.0	2.9	0.0	-1.7	0.1	1.1	-1.1
Hip circumference	0.2	0.8	2.7	0.4	-0.2	0.4	1.0	-1.6
Trunk predicted mass	0.2	1.0	2.7	0.1	-1.6	0.1	1.1	-1.1
Glaucoma (self-reported)	0.2	0.2	0.4	0.1	-0.2	0.6	0.5	-0.6
Worry too long after embarrassment	0.2	0.4	0.7	0.8	0.3	0.9	-0.6	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.6	0.7	-0.1	-0.0	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	-0.2	-0.9	0.3	-0.2	0.2
Neck or shoulder pain in last month	0.2	0.2	0.6	-0.2	-0.3	-0.4	0.6	-0.7
Medication: Blood pressure	0.2	0.3	0.5	-0.5	-0.5	-0.7	0.0	-0.7
Medication: Allopurinol	0.2	0.2	0.5	-0.4	-0.7	-0.4	-0.4	0.0
Medication: Aspirin	0.2	0.2	0.7	0.1	0.5	0.4	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.7	1.3	-0.0	0.6	0.3	-0.6
Mood swings	0.2	0.4	0.9	-0.4	-0.5	-0.4	0.9	-0.7
Qualifications: nursing, teaching	0.2	0.2	0.5	0.7	0.7	0.4	0.1	-0.2
Breast cancer (self-reported)	0.2	0.2	1.1	-0.2	1.0	0.2	0.2	-0.1
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	-0.2	0.1	0.1	0.5	-1.1
Medication: Blood pressure	0.2	0.3	1.3	0.1	0.1	1.1	-0.4	0.3
Arm fat-free mass (left)	0.2	0.9	1.6	0.8	-0.9	0.7	0.9	-1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.0	-0.2	0.8	0.4	-0.8
Arm predicted mass (left)	0.2	1.0	2.0	0.7	-0.9	0.7	1.1	-1.4
Worry (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.5	0.0	-0.4	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.1	0.6	0.4	-0.3	0.0
HDL Cholesterol	0.1	0.2	0.5	0.1	-0.6	0.7	0.3	0.2
Heel T-Score	0.1	0.7	1.2	0.8	-0.3	-0.5	1.1	-1.0
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-1.0	-0.5	-0.1	0.3	0.5
Systolic Blood Pressure	0.1	0.5	1.2	-0.6	-1.1	-0.0	-1.0	0.1
Respiratory disease	0.1	0.1	0.3	0.2	-0.2	0.6	-0.4	0.3
Tanning	0.1	1.6	3.5	1.5	0.4	0.3	1.4	-1.9
Impedance of leg (right)	0.1	0.6	1.0	-0.8	0.0	-1.0	-0.9	0.8
Leg fat-free mass (left)	0.1	0.4	0.5	0.6	-0.7	0.6	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.8	0.3	0.0	-0.5	0.7
Sitting height	0.1	0.7	1.8	-0.5	-1.4	-0.2	-1.1	0.4
Impedance of leg (left)	0.1	0.4	0.6	-0.5	0.1	-0.8	-0.8	0.5
Leg predicted mass (left)	0.1	0.5	0.6	0.7	-0.7	0.7	0.6	-0.8
Waist circumference	0.1	0.2	0.8	0.1	0.3	0.9	0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.2	0.2	-0.3	-0.1	0.5
Fluid intelligence score	0.1	0.2	0.6	-0.5	-0.0	0.2	-0.8	0.5
Neuroticism score	0.1	0.3	0.6	0.1	-0.8	-0.4	0.4	-0.8
Impedance of arm (right)	0.1	0.4	1.2	-0.0	0.6	-0.1	-1.1	0.6
Worrier / anxious feelings	0.1	0.2	0.4	0.4	0.0	0.6	-0.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.4	0.4	0.1	-0.4	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.3	-0.2	-0.1	-0.7	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.5	-0.2	-0.6	0.3	0.4
Asthma	0.1	0.2	0.6	-0.2	-0.2	0.3	-0.8	0.6
Medication: Lansoprazole	0.1	0.1	0.4	-0.2	-0.3	-0.6	-0.4	-0.1
Impedance of arm (left)	0.1	0.5	1.2	-0.3	0.4	-0.6	-1.1	0.8
Birth weight of first child	0.1	0.2	0.3	0.4	0.3	-0.4	0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.5	0.2	-0.5	-0.3	-0.1
Arm fat-free mass (right)	0.1	0.7	1.0	0.6	-1.0	0.4	1.0	-1.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	-0.4	-0.1	-0.7	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.6	0.0	-0.4	0.1	-0.4
Arm predicted mass (right)	0.1	0.6	1.1	0.5	-1.0	0.4	0.9	-0.8
Pulse rate, automated reading	0.1	0.3	0.6	-0.8	-0.8	-0.6	-0.0	0.3
Suffer from ‘nerves’	0.1	0.2	0.4	-0.2	-0.2	0.1	-0.7	0.5
Chest pain or discomfort	0.1	0.2	0.4	0.2	0.1	0.7	0.5	-0.6
Whole body fat-free mass	0.1	0.8	1.4	0.5	-1.2	0.5	0.9	-1.1
Leg fat-free mass (right)	0.1	0.6	0.8	0.7	-0.8	0.6	0.7	-0.9
Back pain experienced in last month	0.1	0.2	0.8	-0.9	-0.2	0.1	0.3	-0.2
Mineral and other dietary supplements	0.1	0.1	0.4	-0.4	-0.1	0.0	-0.0	-0.6
Asthma (self-reported)	0.1	0.3	0.6	-0.3	-0.5	0.3	-0.8	0.6
Medication: Aspirin	0.1	0.1	0.4	-0.5	-0.0	0.1	0.1	-0.7
Whole body water mass	0.1	0.8	1.3	0.6	-1.1	0.5	0.9	-1.1
Leg predicted mass (right)	0.1	0.6	0.8	0.7	-0.8	0.6	0.7	-0.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.2	-0.1	0.5	-0.0	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.4	0.5
Basal metabolic rate	0.1	0.6	0.9	0.8	-0.6	0.8	0.6	-1.0
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.1	-0.9	-0.2	-0.9	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	0.1	0.4	-0.3	-0.1	0.8
Pain experienced in last month	0.1	0.2	0.4	-0.2	-0.6	-0.6	-0.2	0.4
Impedance of whole body	0.1	0.6	1.4	-0.5	0.4	-0.7	-1.2	0.9
Sensitivity / hurt feelings	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	-0.2
High blood pressure	0.0	0.1	0.2	-0.2	-0.4	0.3	-0.2	-0.3
Hypertension (Self-reported)	0.0	0.1	0.5	0.0	-0.2	0.3	-0.7	0.2
Financial situation satisfaction	0.0	0.0	0.1	0.2	0.2	-0.0	0.2	-0.2
Ever depressed for a whole week	0.0	0.0	0.1	0.2	0.3	0.2	-0.1	-0.1
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.1	0.3	0.0	-0.2	0.4

Hub : Genes

SHROOM3

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Trait associations