Hub : Genes

STAG3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0500	0.0220	1.4e-03	0.021	NA	0.025	NA	0.012	6.6e-03	NA	3.7e-03	NA	3.1e-02
2	GTEx	Brain Cerebellar Hemisphere	0.2060	0.0820	6.3e-04	0.109	NA	0.093	NA	0.120	9.8e-04	NA	2.2e-03	NA	5.7e-04
3	GTEx	Brain Cerebellum	0.1450	0.0650	1.2e-03	0.122	NA	0.054	NA	0.104	1.9e-04	NA	1.1e-02	NA	5.5e-04
4	GTEx	Brain Nucleus accumbens basal ganglia	0.2450	0.0960	5.7e-05	0.283	NA	0.257	NA	0.279	2.9e-08	NA	1.5e-07	NA	3.8e-08
5	GTEx	Brain Putamen basal ganglia	0.3580	0.1010	1.8e-04	0.032	NA	0.091	NA	0.094	6.1e-02	NA	3.6e-03	NA	3.1e-03
6	GTEx	Nerve Tibial	0.1284	0.0511	2.0e-06	0.161	NA	0.126	NA	0.145	1.8e-11	NA	3.1e-09	NA	2.0e-10
7	ROSMAP	Brain Pre-frontal Cortex	0.1118	0.0345	1.5e-09	0.122	0.097	0.126	0.11	0.121	2.2e-15	1.9e-12	7.4e-16	5.3e-14	2.5e-15
8	TCGA	Breast Invasive Carcinoma	0.0153	0.0114	3.4e-03	0.006	0.010	0.010	NA	0.008	1.9e-02	3.4e-03	2.5e-03	NA	6.7e-03
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0484	0.0230	1.4e-06	0.051	0.046	0.052	NA	0.048	1.9e-06	6.3e-06	1.4e-06	NA	4.0e-06
10	TCGA	Lung Squamous Cell Carcinoma	0.0188	0.0149	9.9e-03	0.011	0.010	-0.002	NA	0.005	1.8e-02	2.4e-02	6.2e-01	NA	7.2e-02
11	TCGA	Prostate Adenocarcinoma	0.0235	0.0175	6.6e-03	0.028	0.014	0.016	NA	0.005	5.7e-04	1.2e-02	7.3e-03	NA	9.1e-02
12	TCGA	Thyroid Carcinoma	0.0240	0.0180	7.8e-03	0.002	0.010	0.008	NA	-0.003	1.9e-01	3.4e-02	5.5e-02	NA	8.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	2.8	4.5	5.7	-2.3	2.3	2.2	2.3	2.0	-2.2	0.2	-2.2	-2.4	-2.3	-1.7	-2.4
Bipolar Disorder or Schizophrenia	2.0	4.9	10.8	-1.8	2.1	2.2	3.0	3.3	-2.3	0.2	-2.3	-2.5	-2.2	-0.9	-2.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.5	-1.2	0.5	0.5	0.2	0.1	-0.3	-0.9	0.0	-0.2	-0.8	-0.8	-0.6
Depression (Nagel 2018)	1.4	2.1	3.2	-1.7	1.8	1.3	1.3	1.8	-1.2	-0.9	-1.8	-1.2	-1.3	-1.3	-1.4
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.9	-0.6	2.4	2.4	1.7	0.9	-2.2	-2.0	-1.8	-2.0	-1.0	-0.0	-0.7
Neuroticism (Nagel 2018)	0.7	1.6	4.3	-2.1	1.3	1.2	0.8	1.1	-0.8	-0.9	-0.8	-1.3	-1.6	-1.3	-1.4
Schizophrenia (2018)	0.8	1.6	6.9	-0.4	0.9	1.0	1.9	2.6	-1.2	0.1	-1.2	-1.2	-1.0	0.0	-0.9
Schizophrenia vs Biploar Disorder	1.5	2.0	3.6	1.6	-1.8	-1.5	-0.6	0.7	1.4	-0.4	1.7	1.6	1.3	1.9	1.5
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	-1.0	-0.8	-0.7	0.2	1.0	-0.4	0.8	0.7	0.1	-0.4	0.1
Alzheimer’s Disease (in mother)	12.4	14.5	20.2	4.3	-3.1	-3.5	-4.2	-2.6	4.3	2.7	3.6	4.3	4.5	3.9	4.2
Alzheimer’s Disease (in father)	4.8	5.2	9.5	2.8	-1.7	-2.2	-2.3	-2.1	2.1	3.1	1.7	2.4	2.3	2.0	2.2
Alzheimer’s Disease (including proxy)	21.4	31.0	48.0	6.9	-4.9	-5.8	-5.7	-4.6	5.6	4.6	4.9	6.0	6.2	5.1	5.9
Crohns Disease (2017)	1.0	2.3	12.3	-0.5	1.3	1.2	2.2	3.5	-1.3	-1.5	-1.0	-1.3	-0.5	-0.1	-0.4
Irritable Bowel Disease (IBD)	1.5	3.6	7.6	-1.7	1.1	1.5	2.7	2.8	-2.0	-1.3	-2.3	-2.2	-1.7	-0.9	-1.6
Ulcerative Colitis (UC)	0.8	1.4	3.6	-1.4	0.1	0.7	1.5	0.7	-1.4	-0.5	-1.9	-1.7	-1.2	-0.3	-1.3
Major Depression (MDD)	0.4	0.5	1.5	-1.2	0.5	0.8	0.3	0.4	-0.3	0.2	-0.8	-0.7	-0.8	0.0	-0.9
Reaction Time	0.7	1.3	2.9	-1.2	1.1	1.3	1.4	1.6	-1.2	-1.7	-0.8	-1.2	-0.8	0.0	-0.7
Verbal and Numeric Reasoning (VNR)	1.0	2.4	6.2	-0.1	1.8	2.2	1.8	1.7	-2.1	-2.5	-1.0	-1.5	-0.3	0.5	0.1
Breast Cancer	1.7	4.1	9.2	-1.0	3.0	2.7	1.9	1.1	-2.6	-2.5	-2.1	-2.5	-1.3	0.2	-0.9
Ovarian Cancer	0.1	0.1	0.3	0.1	0.5	0.5	0.1	-0.2	-0.4	-0.3	0.2	-0.3	-0.0	0.3	0.3
Prostate Cancer	1.0	1.4	3.3	1.3	-1.6	-1.6	-0.6	0.1	1.2	0.2	1.8	1.2	1.2	0.2	1.4
Age at First Birth	0.3	0.5	3.8	0.3	-0.2	-0.6	-1.0	-1.9	0.2	-0.2	-0.0	0.2	0.2	0.3	0.3
Bipolar Disorder (2011)	1.7	1.7	3.3	-1.1	1.3	1.2	1.6	1.3	-1.6	0.3	-1.6	-1.8	-1.3	0.0	-1.1
Body Mass Index (BMI) (2010)	0.9	1.3	2.6	-1.5	1.3	1.0	0.9	0.8	-0.8	-0.8	-1.0	-0.8	-1.3	-1.6	-1.4
Coronary Artery Disease (CAD)	2.5	3.0	4.7	-1.6	2.2	2.0	1.8	1.8	-1.7	0.8	-1.8	-1.9	-1.8	-1.5	-1.7
Crohns Disease (2012)	0.6	0.9	4.5	1.3	0.3	-0.2	0.6	2.1	0.1	-0.4	0.5	0.3	1.3	0.0	1.4
Mean Putamen Volume	3.3	3.8	7.2	-1.6	1.8	2.7	2.4	1.7	-2.6	-1.6	-1.7	-2.5	-1.9	-0.7	-1.2
Fasting Glucose	0.3	0.4	1.5	-0.6	-0.1	0.4	-0.1	-1.2	-0.4	-0.1	-0.8	-0.4	-0.6	-0.7	-0.8
HbA1C	1.1	1.2	2.4	0.4	-1.6	-1.4	-1.3	-1.5	1.3	0.4	1.1	1.3	0.6	-0.8	0.3
HDL Cholesterol	0.4	0.7	1.9	-1.0	-1.4	-0.7	0.2	0.2	0.3	-1.3	-0.0	0.2	-0.6	-1.2	-0.8
LDL Cholesterol	2.1	3.4	5.0	-2.0	1.4	1.5	2.2	2.2	-1.8	-1.5	-1.9	-2.0	-2.0	-1.5	-1.8
Lupus	0.2	0.2	1.0	-0.7	0.3	0.2	-0.2	-0.4	-0.1	1.0	-0.2	-0.3	-0.6	-0.6	-0.6
Neuroticism (2016)	1.6	2.3	4.8	-2.2	1.1	1.4	1.2	1.2	-1.1	-1.2	-1.5	-1.5	-1.8	-1.7	-1.8
Primary Biliary Cirrhosis	0.3	0.4	2.0	-0.1	-0.2	0.6	0.5	-0.3	-0.8	-1.4	-0.7	-0.7	-0.2	0.0	-0.3
Rheumatoid Arthritis	2.9	3.9	8.5	1.2	-2.1	-2.8	-2.6	-2.9	2.4	1.6	1.2	2.3	1.3	0.9	0.9
Schizophrenia (2014)	1.1	2.4	10.4	-0.7	0.7	1.1	2.5	3.2	-1.6	-0.1	-1.4	-1.6	-1.3	0.0	-1.1
Triglycerides	1.1	1.7	5.2	-0.2	1.8	1.9	1.9	2.3	-1.5	-0.3	-0.8	-1.4	-0.8	-0.1	-0.5
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.0	0.7	-1.8	-2.0	-1.4	-1.3	1.6	0.8	1.5	1.5	0.8	0.0	0.6
Ulcerative Colitis	0.2	0.4	0.8	-0.9	-0.4	0.0	0.7	-0.0	-0.6	-0.3	-0.9	-0.9	-0.6	0.0	-0.7
Blood Eosinophil Count	0.5	4.1	11.3	-2.3	0.2	1.1	2.6	3.2	-1.5	0.5	-0.9	-1.7	-2.1	-3.4	-2.1
Blood Platelet Count	1.7	20.3	83.7	-4.1	-2.6	-2.8	-3.3	-4.8	2.9	9.2	-0.5	1.2	-3.2	-7.3	-4.5
Blood Red Count	3.5	33.4	169.0	5.1	1.3	0.6	1.9	13.0	3.0	-2.4	8.6	2.9	4.7	5.6	7.0
Blood White Count	0.4	2.8	9.8	-2.1	0.3	0.9	1.4	2.2	-0.5	1.5	-0.5	-1.1	-2.1	-3.1	-1.9
Heel T-Score	0.6	4.6	19.3	2.9	0.2	-0.3	-0.7	-1.3	-0.4	-2.6	0.8	0.4	2.8	4.4	3.2
BMI	0.4	2.2	5.3	-2.2	-0.0	0.7	1.2	0.9	-0.8	2.3	-0.9	-1.2	-2.1	-1.6	-2.0
Height	0.4	7.6	15.6	-1.7	3.4	3.7	2.2	1.0	-3.1	-2.7	-4.0	-2.9	-2.6	-1.5	-2.7
Waist Hip Ratio (WHR)	0.5	2.3	7.0	0.4	2.4	2.6	1.4	1.2	-2.1	-1.1	-1.2	-1.9	-0.4	0.4	0.2
Systolic Blood Pressure	0.4	2.0	4.2	-0.8	2.0	1.9	0.9	-0.0	-1.6	2.0	-0.6	-1.8	-1.4	-1.4	-0.9
Smoking Status	0.5	1.1	2.7	-1.3	0.8	0.8	0.6	1.5	-0.2	1.2	-0.8	-0.5	-1.2	-1.6	-1.2
Allergy or Eczema	1.9	5.1	11.5	1.9	-2.5	-2.4	-2.1	-2.6	2.2	0.1	3.4	2.4	2.3	1.2	2.4
Cardiovascular Disease	4.0	13.1	24.3	-3.1	4.0	4.9	4.3	4.4	-4.1	-0.7	-3.2	-4.4	-3.5	-1.6	-2.8
Hypothyroidism (self reported)	1.7	4.0	23.8	1.8	-0.4	-0.9	-2.5	-4.9	0.9	-0.2	1.7	1.3	1.5	1.7	1.8
Respiratory disease	0.8	1.8	17.7	0.3	-0.6	0.3	0.7	-0.2	-0.7	-4.2	1.1	-0.3	0.3	-0.1	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	-0.4	0.8	1.3	0.2	-1.4	-1.2	-0.5	-0.3	-1.3	-0.9	-0.1	-0.4
Lung FEV1/FVC ratio	3.4	17.3	47.9	2.6	-5.0	-5.2	-4.7	-3.7	4.9	6.9	1.7	4.8	2.8	2.1	1.9
Lung FVC	2.6	13.0	18.1	-3.4	3.6	3.9	4.1	3.6	-3.8	-2.2	-4.2	-4.2	-3.7	-2.1	-3.5
Neuroticism	0.2	0.4	1.6	-1.2	-0.2	0.1	0.1	0.6	0.1	-1.3	0.5	-0.0	-0.5	-0.8	-0.4
Chronotype (morning person)	0.2	0.5	2.1	-0.8	-0.8	-0.7	-0.4	-0.8	0.3	-1.4	-0.1	0.0	-0.4	-0.6	-0.5
Hair Pigment	0.2	6.2	37.1	1.2	-1.9	-1.9	-3.6	-6.1	1.9	1.6	1.3	2.1	1.3	0.8	1.1
Tanning	0.1	0.8	2.3	-1.1	-0.1	0.2	-0.5	-0.2	0.5	1.5	-0.6	0.3	-0.9	-1.4	-1.5
Hand grip strength (left)	2.9	7.7	17.8	-1.2	2.0	2.8	3.3	2.9	-3.3	-3.6	-4.2	-3.1	-2.1	-0.1	-2.0
Number of treatments/medications taken	0.1	0.2	0.6	-0.0	0.0	0.5	0.6	0.2	-0.6	-0.7	0.6	-0.8	-0.0	0.5	0.4
Average weekly spirits intake	0.5	0.6	4.5	0.5	-0.2	-0.3	-0.5	-0.1	0.6	2.1	0.5	0.3	0.2	1.0	0.3
Sensitivity / hurt feelings	0.3	0.4	1.9	-0.0	-0.1	-0.0	-1.0	-1.4	0.6	1.3	0.4	0.4	0.0	0.1	0.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.0	-0.9	0.5	0.2	0.5	0.3	-0.4	-1.4	-0.9	-0.4	-0.6	-0.6	-0.6
Hearing difficulty/problems: Yes	1.8	2.8	5.5	-1.8	1.0	1.5	1.5	-0.1	-2.1	-0.7	-2.0	-2.1	-2.3	-1.5	-2.0
Relative age of first facial hair	1.9	3.9	7.5	-2.3	2.3	1.8	1.0	-0.3	-1.6	0.5	-2.6	-1.9	-2.5	-2.1	-2.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.3	0.5	-1.5	-0.9	-0.8	-1.5	0.3	-0.5	0.9	0.3	0.5	0.6	0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	6.2	-0.2	-0.6	-0.8	-1.0	-1.0	0.9	2.5	0.0	0.7	-0.1	-1.1	-0.5
Ever had hysterectomy (womb removed)	1.6	1.8	3.9	1.1	-1.4	-1.5	-1.9	-2.0	1.5	1.5	1.0	1.2	0.9	0.4	0.8
Systolic blood pressure, automated reading	0.3	0.9	6.7	0.2	1.1	0.8	0.5	0.0	-0.9	2.6	-0.3	-1.1	-0.5	-0.1	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.2	0.0	-0.2	-0.0	-0.6	-0.7	0.4	1.1	0.1	0.1	0.1	0.2	0.1
Angina	0.1	0.1	0.5	-0.4	0.0	0.1	-0.3	-0.7	0.1	-0.2	0.6	-0.1	-0.0	-0.1	0.1
Medication for hormone replacement therapy	0.8	0.9	5.2	-1.1	-0.0	0.1	-0.0	-0.0	-0.2	0.8	-0.5	-0.3	-1.1	-2.3	-1.2
Vitamin and mineral supplements	0.5	0.7	3.0	0.1	1.7	1.4	0.6	1.0	-0.7	0.9	-0.8	-0.6	-0.1	0.3	-0.0
Supplements: Zinc	1.2	1.3	2.8	-1.1	0.8	1.0	1.0	-0.2	-1.3	-1.7	-0.8	-1.1	-1.3	-1.3	-1.2
Medication: Co-codamol	0.3	0.3	1.1	-0.7	-0.3	0.3	0.1	-0.2	-0.3	1.1	-0.2	-0.3	-0.7	-0.9	-0.8
Medication: Metformin	0.2	0.3	1.8	-0.4	0.3	0.6	-0.0	-1.3	-0.7	-0.3	-0.3	-0.7	-0.4	0.4	-0.3
Diabetes (father)	0.2	0.3	0.7	0.6	0.4	-0.1	-0.6	-0.7	0.3	-0.3	0.8	0.4	0.6	0.6	0.7
Diabetes (mother)	0.8	1.0	2.4	0.7	-0.2	-0.2	-1.2	-1.0	1.0	1.4	1.5	0.9	0.8	0.9	0.9
Severe depression (siblings)	0.4	0.5	1.5	0.1	0.0	0.6	1.0	1.2	-0.8	0.1	-0.7	-0.9	-0.3	0.9	-0.0
Pack years adult smoking proportion	3.9	5.9	8.0	-2.8	2.3	2.4	2.5	1.4	-2.7	-1.4	-2.5	-2.8	-2.8	-2.4	-2.6
Impedance of leg (right)	1.1	5.4	14.1	-0.4	3.2	3.0	2.7	3.8	-2.4	-3.2	-1.0	-2.2	-0.5	1.4	0.0
Leg fat-free mass (left)	0.2	0.9	2.4	-1.1	-0.5	-0.1	-0.3	-1.1	0.2	1.2	-1.1	0.0	-1.0	-1.6	-1.4
Trunk fat percentage	1.1	4.4	7.1	-2.2	2.1	2.6	2.7	1.9	-2.5	-0.1	-2.1	-2.6	-2.3	-0.6	-1.9
Hand grip strength (right)	3.3	9.0	17.2	-1.4	1.9	3.0	3.9	3.7	-3.5	-3.7	-4.1	-3.3	-2.2	-0.6	-2.2
Townsend deprivation index at recruitment	2.4	3.4	5.7	-1.7	2.0	1.7	2.1	2.1	-1.8	0.4	-2.4	-2.0	-1.9	-1.5	-1.8
Current tobacco smoking	0.1	0.2	1.0	0.3	-0.7	-0.6	0.2	1.0	0.4	0.4	0.2	0.3	0.1	-0.2	0.1
Average weekly fortified wine intake	0.6	0.7	1.4	0.8	-0.6	-0.9	-1.2	-1.1	1.0	0.5	0.7	0.8	0.7	0.9	0.7
Maternal smoking around birth	0.8	1.2	4.3	-1.5	2.1	0.9	0.1	0.3	-0.2	1.4	-0.7	-0.6	-1.1	-1.1	-1.3
Fed-up feelings	0.7	1.3	3.2	-1.0	-1.8	-1.5	-1.2	-0.4	1.8	0.3	1.0	1.4	-0.1	-0.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	-0.8	0.6	0.3	0.5	0.9	-0.2	-0.9	-0.6	-0.2	-0.2	-0.2	-0.3
Relative age voice broke	2.3	3.5	7.6	-2.8	1.6	1.7	1.2	0.8	-1.3	-0.6	-2.2	-1.9	-2.4	-1.9	-2.6
Taking other prescription medications	0.2	0.3	1.5	0.1	-0.1	-0.3	-0.6	-1.2	0.1	-0.5	0.6	0.1	0.4	0.6	0.3
Age when periods started (menarche)	6.1	14.6	22.9	-4.8	4.2	4.4	3.2	1.8	-3.8	-1.5	-4.5	-4.0	-4.4	-3.3	-4.5
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	9.7	0.4	-1.3	-1.3	-2.2	-1.3	2.1	3.1	1.0	1.7	0.8	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.0	1.4	0.8	0.0	-0.3	0.1	0.2	-0.8	0.5	0.4	1.4	2.2	1.7
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	3.9	0.8	-1.7	-1.6	-1.3	-1.6	1.4	1.3	2.0	1.4	1.1	0.7	1.1
Qualifications: CSEs or equivalent	1.0	1.4	2.6	0.6	-1.4	-1.6	-1.0	-0.8	1.4	-1.5	1.3	1.3	1.1	0.3	0.9
Serious illness, injury or assault to yourself	0.4	0.5	2.3	-0.8	-0.8	-0.4	-0.5	-0.1	0.7	1.5	0.3	0.2	-0.5	-1.0	-0.7
High blood pressure	5.0	13.9	25.2	-3.5	4.2	5.0	4.3	3.9	-4.3	-1.2	-3.3	-4.5	-3.7	-2.0	-3.1
Hayfever, allergic rhinitis or eczema	1.7	3.8	8.7	1.4	-2.3	-2.1	-1.9	-2.4	2.0	1.0	2.9	2.2	1.8	0.4	1.8
Multivitamins +/- minerals	0.7	0.9	2.9	-0.9	-1.7	-1.2	-0.9	-1.1	0.8	-1.1	0.7	0.5	-0.5	-0.9	-0.6
Stomach or abdominal pain in last month	4.2	5.3	12.8	2.0	-2.4	-2.3	-2.8	-3.6	2.1	0.8	2.5	2.4	2.1	1.2	1.8
Supplements: Glucosamine	2.1	2.7	12.4	1.1	-1.7	-1.5	-2.0	-3.5	1.3	-0.0	1.4	1.3	1.3	1.2	1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.6	0.8	-1.0	-1.4	-1.3	-0.6	1.4	2.4	0.5	1.2	0.8	0.3	0.4
Medication: Atenolol	2.6	3.3	5.2	-1.9	1.9	2.3	1.8	0.6	-2.2	-0.1	-2.1	-2.1	-1.9	-1.8	-1.9
Medication: Levothyroxine sodium	3.1	5.2	18.2	2.2	-0.9	-1.6	-3.0	-4.3	1.8	1.3	2.2	1.9	2.2	2.2	2.2
Sitting height	0.5	3.7	8.3	2.2	-1.6	-2.0	-2.6	-2.9	2.0	-0.2	0.9	2.2	2.0	1.0	1.6
Chronic bronchitis/emphysema (father)	1.9	2.2	3.5	-1.8	0.2	1.2	1.7	1.9	-1.3	-1.2	-1.6	-1.7	-1.8	-0.9	-1.6
High blood pressure (mother)	0.3	0.4	1.3	-1.0	0.3	0.3	0.2	-0.1	-0.1	-1.2	-0.1	-0.1	-0.6	-1.0	-0.7
Body mass index (BMI)	0.3	1.4	5.4	-1.5	0.1	0.5	0.9	0.5	-0.6	2.3	-1.1	-1.0	-1.6	-1.1	-1.5
Impedance of leg (left)	1.3	6.3	15.9	-0.4	3.2	3.1	3.1	4.0	-2.8	-3.5	-1.1	-2.5	-0.7	1.4	0.1
Leg predicted mass (left)	0.2	1.0	2.5	-1.2	-0.4	-0.0	-0.3	-1.1	0.1	1.2	-1.2	-0.1	-1.1	-1.6	-1.5
Trunk fat mass	0.9	4.0	5.7	-2.1	1.9	2.4	2.3	1.6	-2.2	0.1	-2.3	-2.4	-2.3	-0.9	-2.0
Waist circumference	0.2	0.9	1.6	-0.7	0.7	1.2	0.9	0.2	-1.1	1.3	-1.1	-1.1	-1.0	-0.4	-0.8
Number of incorrect matches in round	0.6	1.0	1.8	-0.4	0.9	0.7	1.3	1.2	-1.3	-0.8	-1.4	-1.3	-0.7	0.6	-0.4
Past tobacco smoking	1.3	2.4	4.6	2.1	-2.1	-1.7	-0.2	-0.2	0.7	-1.3	1.5	1.2	1.8	2.1	1.9
Alcohol usually taken with meals	0.7	1.2	3.3	1.1	-0.4	-0.5	-1.0	-0.6	0.9	-0.4	1.8	1.3	1.4	1.2	1.4
Nervous feelings	0.1	0.1	0.6	-0.3	0.3	0.3	-0.3	0.1	0.2	-0.4	0.8	0.2	0.1	-0.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	2.5	-0.1	-0.2	-0.2	-0.1	0.5	0.2	-1.6	-0.5	0.2	0.1	-0.0	0.0
Hearing difficulty/problems with background noise	1.8	2.8	5.3	-1.4	1.1	1.8	2.0	0.7	-2.3	-2.0	-1.4	-2.1	-2.0	-0.7	-1.5
Hair/balding pattern: Pattern 2	2.1	2.7	4.7	-1.3	1.1	1.4	2.2	1.7	-2.1	-2.0	-1.7	-2.1	-1.5	-0.6	-1.2
Had menopause	0.6	0.7	6.4	-0.2	-0.1	0.0	0.4	0.1	-0.4	2.5	-0.7	-0.2	-0.7	-0.3	-0.8
Had other major operations	4.2	5.1	11.3	0.9	-2.6	-2.6	-2.9	-3.4	2.5	3.2	2.1	2.1	1.1	-0.1	0.8
Forced vital capacity (FVC)	0.9	3.3	7.3	-1.5	1.2	1.9	1.8	1.1	-1.9	-2.7	-2.5	-1.9	-1.7	-0.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.3	0.8	1.6	0.9	0.5	0.9	-0.7	-1.2	-0.4	-0.6	0.6	2.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.9	0.4	-0.1	-0.7	-1.1	-0.3	1.1	1.7	-0.2	0.7	0.8	0.3	0.5
Qualifications: None of the above	0.6	1.3	5.7	-1.1	0.3	0.1	0.5	0.6	-0.2	2.4	-0.9	-0.6	-1.3	-1.9	-1.5
Financial difficulties in last 2 years	0.2	0.2	1.0	0.5	-0.5	-0.4	-0.1	-0.3	0.2	-0.6	0.4	0.3	0.5	1.0	0.5
Mouth/teeth dental problems	1.9	2.9	4.8	-1.9	1.1	2.1	1.8	0.5	-1.9	-0.6	-2.0	-2.2	-2.1	-1.0	-1.9
Heart attack	0.1	0.1	0.7	0.2	-0.1	0.1	-0.2	-0.8	-0.0	-0.3	-0.1	0.0	0.3	-0.2	0.1
Allergy	2.1	4.8	11.4	-1.7	2.8	2.2	2.0	3.4	-1.7	0.2	-3.1	-2.3	-2.1	-0.4	-2.1
Pain all over the body in last month	0.6	0.6	2.3	-1.5	0.2	0.4	0.1	0.7	0.1	-0.0	-0.9	-0.2	-1.0	-0.9	-1.3
Diabetes (self-reported)	0.2	0.4	1.7	0.0	0.4	0.8	0.1	-1.3	-1.0	-0.1	-0.2	-1.0	-0.4	0.2	0.0
Hayfever/allergic rhinitis (self-reported)	4.6	6.1	11.5	1.5	-2.9	-2.8	-2.9	-3.4	2.7	2.7	2.3	2.8	1.9	1.0	1.4
Medication: Ramipril	0.4	0.5	0.8	-0.9	-0.4	0.8	0.9	-0.0	-0.9	-0.6	-0.6	-0.9	-0.7	-0.4	-0.7
Medication: Simvastatin	3.1	4.5	9.5	-1.1	2.4	3.1	2.7	1.8	-3.0	-0.5	-2.0	-3.0	-1.9	0.3	-1.1
Fluid intelligence score	1.0	2.1	5.7	0.3	1.9	1.8	1.6	2.3	-1.5	-2.4	-0.7	-1.1	0.3	1.0	0.6
Illnesses of siblings	2.9	4.1	8.7	0.3	-2.9	-2.9	-2.4	-1.2	2.9	1.1	2.4	2.7	1.2	-0.6	0.7
Neuroticism score	0.2	0.3	1.4	-1.2	-0.1	0.3	0.1	0.3	0.0	-1.0	0.4	-0.0	-0.6	-0.8	-0.5
Weight	0.4	1.8	3.5	-1.6	0.8	1.3	1.2	0.5	-1.1	0.9	-1.9	-1.3	-1.8	-1.2	-1.8
Impedance of arm (right)	0.4	2.1	8.2	-0.4	2.7	2.1	0.8	1.1	-1.1	-2.9	-0.2	-1.0	-0.1	1.0	0.2
Arm fat percentage (right)	0.3	1.2	2.3	-1.5	0.8	1.2	1.2	0.8	-1.0	0.9	-1.1	-1.2	-1.4	-0.6	-1.2
Trunk fat-free mass	0.1	0.5	1.2	-0.2	-0.8	-0.5	-0.5	-1.1	0.3	0.9	-0.9	0.3	-0.4	-0.9	-0.8
Hip circumference	0.1	0.4	1.2	-1.0	0.1	0.3	0.3	-0.2	-0.2	1.1	-0.7	-0.3	-1.0	-0.5	-1.1
Time employed in main current job	0.4	0.5	2.0	-0.6	0.3	0.1	1.0	1.3	-0.7	-1.4	-0.2	-0.6	-0.3	-0.2	-0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-1.0	0.6	-0.2	-0.8	-0.4	0.7	1.0	0.3	0.0	-0.7	-1.0	-0.7
Father’s age at death	2.3	3.1	7.7	0.9	-2.8	-2.4	-1.9	-2.2	2.0	1.6	1.4	2.0	1.0	-0.4	0.6
Worrier / anxious feelings	0.2	0.4	2.4	-0.8	0.5	0.4	0.3	1.0	-0.1	-1.5	0.1	-0.3	-0.4	-0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.8	0.3	-1.3	-1.2	-1.0	-1.3	0.8	-0.8	0.7	0.8	0.4	0.1	0.5
Falls in the last year	0.7	0.9	2.2	0.7	-1.2	-1.4	-0.9	-0.4	1.1	1.5	0.0	0.9	0.8	0.9	0.5
Hair/balding pattern: Pattern 3	3.5	5.2	9.0	2.2	-1.7	-2.1	-3.0	-2.5	2.6	0.9	2.6	2.9	2.5	1.4	2.2
Number of live births	0.3	0.4	1.0	-0.0	1.0	1.0	0.7	1.0	-0.7	-0.6	0.1	-0.5	-0.2	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	-0.2	-0.6	-0.3	-0.6	-0.9	0.4	0.1	-1.1	0.3	-0.3	-0.1	-0.6
Pulse rate	11.5	19.4	56.4	-4.5	3.5	3.8	5.5	7.5	-3.7	-0.6	-4.0	-4.0	-4.7	-3.5	-4.5
Happiness	1.7	2.0	3.9	1.5	-1.3	-1.6	-1.2	-0.7	1.5	0.3	1.4	1.6	1.7	2.0	1.6
Noisy workplace	0.5	0.6	3.4	0.4	-0.4	-0.7	-0.8	-0.7	0.9	1.8	0.4	0.8	0.5	0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.8	1.6	0.1	-0.3	-0.9	-0.7	0.3	-0.9	0.4	0.7	1.6	1.5	1.7
Serious illness, injury or assault of a close relative in last 2 years	6.8	7.9	14.7	3.2	-1.3	-2.0	-2.7	-1.7	2.7	-0.1	3.7	3.0	3.7	3.2	3.8
Mouth/teeth dental problems: Dentures	1.6	2.7	6.7	1.1	-0.8	-1.8	-2.1	-1.2	2.0	2.6	1.8	2.1	1.2	0.4	0.9
Asthma	0.5	1.0	9.2	-0.2	0.0	0.7	1.0	0.1	-1.0	-3.0	0.3	-0.7	-0.1	-0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	1.4	-0.4	-0.5	-0.8	-1.4	0.5	-0.3	0.2	0.6	1.2	1.0	1.0
Medication: Cholesterol lowering	7.1	11.0	17.8	-3.5	3.3	4.1	3.6	2.0	-4.0	-0.7	-3.4	-4.2	-3.8	-2.0	-3.3
Depression (self-reported)	0.3	0.4	1.4	-1.2	0.2	0.1	-0.2	0.3	0.3	0.6	-0.7	-0.3	-0.9	-0.8	-1.0
Medication: Lansoprazole	1.1	1.2	4.0	1.5	-0.8	-0.6	-0.4	0.2	0.6	2.0	0.6	0.5	1.3	1.5	1.5
Prospective memory result	0.2	0.2	0.9	0.1	-0.7	-0.3	0.3	0.9	0.3	0.9	0.5	0.4	-0.0	-0.1	0.1
Lung cancer (father)	0.9	1.0	6.5	-0.4	-1.5	-1.1	-0.6	-0.3	0.9	2.5	0.1	0.6	-0.0	-0.0	-0.3
Illnesses of mother	1.2	1.4	3.2	1.5	-1.8	-1.6	-1.1	-0.8	1.2	0.2	1.1	1.3	1.3	0.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.1	-0.6	-0.4	-0.7	-0.8	0.6	0.6	-0.8	0.5	-0.0	-0.1	-0.4
Pulse wave Arterial Stiffness index	0.6	0.7	3.3	-0.3	0.9	0.9	1.1	1.8	-0.7	0.5	-0.3	-1.0	-0.7	0.3	-0.2
Impedance of arm (left)	0.6	2.8	12.0	-0.5	2.7	2.3	1.2	1.4	-1.4	-3.5	-0.4	-1.2	-0.1	1.3	0.2
Arm fat mass (right)	0.4	1.6	2.7	-1.6	0.6	1.2	1.2	0.7	-1.1	1.4	-1.4	-1.2	-1.6	-1.0	-1.5
Trunk predicted mass	0.1	0.5	1.3	-0.1	-0.9	-0.5	-0.6	-1.1	0.3	0.8	-0.9	0.3	-0.4	-0.9	-0.8
Standing height	0.2	1.7	7.4	-0.3	1.6	1.8	0.7	-0.0	-1.4	-2.7	-1.8	-1.0	-0.6	-0.2	-0.8
Length of working week for main job	0.7	0.8	1.9	-0.6	-0.1	0.6	1.0	0.3	-1.2	0.2	-1.4	-1.2	-0.9	-0.8	-0.9
Exposure to tobacco smoke at home	0.6	0.7	5.4	-0.2	-0.4	-0.3	-0.6	-0.7	0.4	2.3	-0.1	0.3	-0.3	-0.9	-0.5
Breastfed as a baby	0.6	0.7	1.6	1.3	-1.0	-0.6	-0.5	-0.9	0.4	1.2	1.1	0.5	0.7	0.6	1.0
Tense / ‘highly strung’	0.4	0.7	1.5	-1.2	0.0	0.6	0.9	1.0	-0.6	-0.9	-0.9	-0.6	-1.0	-0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	-0.1	0.4	-0.1	-0.7	-0.0	0.6	-0.1	0.0	0.3	0.2	0.7	0.1
Hair/balding pattern: Pattern 4	0.7	1.8	6.6	1.6	-1.4	-1.3	-0.7	-0.3	1.0	-0.4	1.1	1.0	1.5	2.6	1.8
Birth weight of first child	0.2	0.3	1.9	0.5	0.3	0.2	0.0	0.5	-0.1	0.7	-1.4	-0.1	0.2	0.7	-0.1
Peak expiratory flow (PEF)	0.9	2.0	6.6	0.9	-1.8	-1.6	-1.9	-2.6	1.5	1.3	0.1	1.4	1.0	0.6	0.5
Pulse wave reflection index	0.9	1.1	2.9	1.4	0.5	0.1	-0.9	-0.5	0.6	-0.4	0.8	0.6	1.4	1.7	1.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.2	-1.5	1.0	1.3	0.7	0.1	-1.0	0.4	-1.3	-1.3	-1.4	-1.0	-1.4
Loud music exposure frequency	0.2	0.2	0.5	-0.6	0.5	0.7	0.4	0.6	-0.4	-0.2	-0.0	-0.2	-0.4	-0.4	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.5	-0.5	1.1	1.2	0.3	0.5	-0.6	-0.4	-0.6	-0.7	-0.4	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.7	1.3	-1.2	-1.2	-1.5	-1.6	1.1	0.7	0.8	1.2	1.4	0.8	1.1
Blood clot in the leg (DVT)	2.4	3.1	9.8	1.4	-1.4	-1.5	-2.4	-3.1	1.6	2.0	1.2	1.9	1.5	0.7	1.1
Medication: Paracetamol	0.1	0.2	0.9	-0.5	-0.0	-0.0	0.4	0.1	-0.3	-0.3	-0.1	-0.4	-0.6	-0.9	-0.6
Headache pain in last month	0.4	0.7	1.5	0.7	-0.6	-0.7	-0.9	-1.2	0.6	-0.8	0.9	0.7	1.0	0.9	1.0
Medication for cholesterol, blood pressure or diabetes	8.9	14.7	23.6	4.2	-3.8	-4.7	-4.2	-2.5	4.6	1.9	3.5	4.9	4.3	2.3	3.7
Glaucoma (self-reported)	0.3	0.4	0.7	0.8	0.7	-0.0	-0.2	0.7	0.4	0.4	0.8	0.6	0.7	0.1	0.8
Gout (self-reported)	0.5	0.8	1.3	-0.9	1.1	1.1	0.9	0.9	-0.7	1.2	-1.0	-0.7	-0.7	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	20.4	1.7	-0.4	-0.9	-2.6	-4.5	1.1	0.5	1.5	1.3	1.5	1.7	1.6
Medication: Amlodipine	1.9	2.6	5.1	-1.6	0.5	1.6	2.3	1.8	-2.0	-0.9	-1.7	-2.2	-1.7	-0.6	-1.4
Medication: Ventolin 100micrograms inhaler	2.6	3.3	5.6	-1.9	2.0	2.2	1.8	1.0	-2.0	-2.4	-1.0	-1.9	-1.6	-1.9	-1.4
Birth weight	2.5	5.4	9.4	-3.1	1.8	2.5	2.0	1.2	-2.0	-0.7	-2.9	-2.2	-2.8	-2.4	-3.0
Chronic bronchitis/emphysema (mother)	4.9	5.7	9.0	-3.0	2.0	2.7	2.8	2.6	-2.5	-0.5	-2.2	-2.9	-2.5	-1.1	-2.4
High blood pressure (siblings)	1.0	1.5	4.1	0.2	2.0	1.8	0.7	-0.1	-1.5	0.3	-2.0	-1.5	-0.4	1.2	-0.3
Forced vital capacity (FVC), Best measure	0.7	2.5	4.6	-1.5	1.3	1.6	1.4	0.9	-1.5	-2.1	-2.1	-1.6	-1.6	-1.2	-1.6
Body fat percentage	1.2	4.6	7.6	-2.2	2.0	2.6	2.7	2.3	-2.4	0.2	-2.1	-2.6	-2.4	-0.6	-1.9
Leg fat percentage (right)	1.4	5.0	10.4	-1.8	2.2	2.6	3.1	3.2	-2.5	0.3	-2.1	-2.7	-2.1	-0.1	-1.5
Arm fat-free mass (right)	0.2	0.8	2.4	-0.8	-0.5	0.1	0.5	-0.1	-0.4	1.0	-1.6	-0.5	-1.1	-1.2	-1.4
Exposure to tobacco smoke outside home	1.2	1.6	3.6	-1.7	0.9	0.5	0.8	0.3	-0.7	1.2	-1.6	-1.0	-1.7	-1.6	-1.9
Comparative body size at age 10	0.1	0.3	1.0	0.2	0.3	-0.1	-0.2	-0.3	-0.2	-1.0	-0.8	-0.2	0.4	1.0	0.3
Number of full brothers	0.3	0.4	2.4	0.4	1.5	0.9	-0.1	-0.1	-0.0	-0.3	0.5	0.0	0.5	0.1	0.7
Worry too long after embarrassment	0.9	1.4	3.5	-1.1	1.5	1.5	1.3	1.9	-1.1	-1.3	-0.6	-1.1	-0.9	-0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.0	-2.0	1.4	1.2	0.6	1.0	-0.7	-0.3	-1.3	-1.0	-1.4	-1.6	-1.6
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.7	-0.2	-0.5	0.7	0.7	-0.1	-1.1	0.3	-0.2	-0.4	-0.7	-0.3
Number of children fathered	1.8	2.0	4.0	1.0	-0.7	-1.0	-1.7	-1.4	1.6	2.0	1.8	1.8	1.3	0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.0	0.0	1.9	2.2	1.8	1.9	-1.8	-1.4	-0.7	-1.7	-0.4	0.8	0.0
Age at first live birth	1.4	2.5	5.7	2.0	-1.0	-1.4	-1.5	-2.4	0.8	-0.8	1.4	1.2	1.9	1.6	2.0
Pulse wave peak to peak time	0.5	0.6	2.9	0.3	-0.6	-0.7	-1.1	-1.7	0.7	-0.6	0.2	1.0	0.7	-0.3	0.2
Health satisfaction	0.5	0.7	2.5	0.5	-0.1	-0.3	-1.0	-0.8	0.7	1.0	1.0	0.6	0.7	1.6	0.8
Shortness of breath walking on level ground	0.5	0.6	2.1	-1.2	0.2	0.6	0.5	0.3	-0.5	-0.4	-0.2	-0.6	-1.0	-1.4	-0.9
Qualifications: College or University degree	0.3	1.0	4.0	0.9	1.4	0.9	-0.1	-0.2	-0.6	-2.0	0.0	-0.3	0.9	1.3	1.1
Eye problems/disorders: None of the above	1.1	1.3	2.1	1.2	-1.2	-1.4	-1.1	-0.1	1.4	0.5	0.8	1.3	1.1	1.3	1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.1	0.4	0.7	1.1	0.7	-1.1	-0.9	-1.2	-0.9	-0.2	0.4	-0.2
Emphysema/chronic bronchitis	2.1	2.3	4.6	-2.0	1.4	1.5	1.0	-0.3	-1.5	-0.8	-1.5	-1.6	-1.8	-2.2	-1.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	-0.7	0.9	0.2	0.2	1.4	0.2	0.6	-0.5	0.0	-0.7	-0.8	-0.8
Neck or shoulder pain in last month	2.5	3.6	6.5	0.6	-2.4	-2.5	-2.4	-2.6	2.4	0.1	2.2	2.4	1.2	0.3	0.9
Medication: Blood pressure	5.8	10.3	16.1	-3.8	3.2	4.0	3.4	2.4	-3.7	-2.2	-2.6	-3.9	-3.4	-2.0	-3.0
Angina (self-reported)	0.1	0.1	0.6	-0.3	0.0	0.0	-0.5	-0.8	0.2	-0.0	0.7	0.0	0.1	-0.1	0.2
Migraine (self-reported)	0.7	0.9	2.6	1.3	-1.6	-1.2	-0.8	-1.1	0.6	-0.0	0.7	0.8	0.9	0.7	0.9
Medication: Ibuprofen	0.9	1.1	2.2	1.4	-0.5	-0.7	-0.9	-1.2	0.8	-0.5	0.6	0.9	1.5	1.3	1.3
Medication: Allopurinol	1.1	1.4	2.1	-1.5	0.9	1.4	1.2	0.7	-1.2	0.9	-1.3	-1.3	-1.3	-0.7	-1.4
Medication: Omeprazole	0.4	0.5	1.6	-0.7	-0.4	-0.3	-1.0	-1.2	0.7	1.3	0.2	0.4	-0.1	-0.1	-0.3
Medication: Seretide 50 evohaler	1.6	1.9	4.4	-2.1	0.8	1.3	1.4	0.8	-1.1	-1.4	-0.4	-1.0	-1.5	-2.0	-1.6
Mean time to correctly identify matches	0.8	1.5	2.6	-0.8	1.3	1.5	1.6	1.6	-1.5	-1.4	-0.8	-1.4	-0.8	0.4	-0.6
Heart disease (mother)	1.2	1.5	5.7	-0.2	1.2	1.5	1.4	0.6	-1.6	-2.4	-0.8	-1.3	0.0	1.2	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	0.2	-1.3	-1.2	-1.0	-0.8	1.1	-0.2	1.0	1.3	0.9	0.2	0.5
Whole body fat mass	0.8	3.5	5.2	-2.2	1.5	2.1	2.2	1.7	-1.9	0.7	-2.0	-2.2	-2.3	-1.0	-2.0
Leg fat mass (right)	0.8	3.1	4.9	-1.7	1.6	2.0	2.2	2.0	-1.9	1.0	-1.9	-2.1	-1.9	-0.5	-1.6
Arm predicted mass (right)	0.1	0.7	2.2	-0.7	-0.5	0.1	0.6	0.0	-0.5	0.6	-1.5	-0.5	-1.1	-1.3	-1.3
Pulse rate, automated reading	15.5	50.1	163.8	-6.5	6.4	6.6	9.0	12.8	-6.1	-2.0	-6.8	-6.6	-6.8	-3.9	-6.2
Alcohol intake frequency.	1.3	3.1	9.4	-0.3	-2.0	-2.4	-2.0	-1.4	2.3	3.1	1.4	1.6	0.2	-1.5	-0.1
Comparative height size at age 10	0.1	0.7	2.0	0.8	-0.6	-0.7	-1.3	-1.4	0.9	0.7	0.4	0.9	0.7	0.1	0.5
Number of full sisters	2.7	3.2	5.6	-1.4	2.1	2.1	1.9	0.8	-2.3	-0.8	-2.3	-2.4	-1.9	-1.0	-1.6
Suffer from ‘nerves’	0.3	0.4	2.1	-0.6	-1.4	-0.8	-0.1	0.3	0.6	0.4	0.2	0.4	-0.5	-1.0	-0.5
Overall health rating	0.6	1.3	2.4	0.8	-1.5	-1.5	-1.1	-0.9	1.2	0.9	1.3	1.1	1.0	1.2	1.0
Chest pain or discomfort	0.1	0.2	1.6	-0.1	-0.0	0.0	0.1	0.2	0.1	-0.3	1.3	0.3	0.2	0.4	0.5
Had major operations	0.9	1.1	2.6	0.2	-1.1	-1.1	-1.4	-0.5	1.6	-0.3	1.6	1.2	0.9	0.5	0.7
Age at last live birth	0.4	0.6	1.5	0.8	0.7	0.4	0.7	0.5	-0.7	-1.2	0.3	-0.5	0.7	1.2	1.1
Family relationship satisfaction	0.2	0.2	1.0	0.1	-0.2	-0.0	0.6	1.0	-0.3	-0.6	-0.5	-0.1	0.1	0.5	0.1
Leg pain on walking	6.1	7.6	11.3	3.1	-2.5	-2.4	-2.7	-2.8	2.5	1.3	3.4	2.8	3.1	2.9	3.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.0	0.6	-1.6	-1.9	-1.5	-0.6	2.0	1.4	1.3	1.6	0.8	0.0	0.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.7	1.3	-0.9	-1.3	-1.3	-0.1	1.6	1.6	1.4	1.6	1.2	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	7.1	-1.9	1.9	2.2	2.5	1.8	-2.7	-1.0	-2.6	-2.5	-2.2	-1.4	-2.2
Medication: Aspirin	0.3	0.4	1.2	0.8	0.1	0.3	-0.3	-0.9	-0.3	0.1	0.3	-0.1	0.8	1.1	1.0
Supplements: Vitamin C	1.7	2.0	3.8	1.6	-1.8	-1.8	-0.6	-1.7	0.6	-1.9	1.5	0.7	1.3	0.8	1.6
Knee pain experienced in last month	2.2	3.4	6.1	0.8	-1.8	-2.4	-2.4	-2.5	2.3	1.3	2.0	2.2	1.4	0.4	1.1
Hypertension (Self-reported)	5.6	15.6	26.4	-3.7	4.1	5.1	4.7	4.1	-4.6	-1.7	-3.7	-4.7	-4.0	-2.1	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.7	4.3	6.1	1.9	-2.5	-2.4	-2.5	-2.4	2.2	1.3	1.9	2.2	2.0	1.4	1.9
Illnesses of father: Heart disease	1.5	2.0	4.9	-0.2	2.2	2.2	1.7	1.8	-1.8	-0.3	-1.2	-1.6	-0.7	0.7	-0.4
Illnesses of siblings: Diabetes	2.1	2.6	5.7	1.9	-1.3	-1.3	-1.3	-1.3	1.2	0.2	1.7	1.4	1.9	2.4	2.1
Smoking status: Previous	1.5	2.2	5.4	-1.9	2.3	1.8	-0.3	-0.5	-0.5	1.6	-1.3	-1.0	-1.6	-1.9	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	-0.9	-0.2	0.1	-0.1	-0.8	-0.2	-1.1	-1.0	-0.1	-0.5	-1.3	-1.0
Whole body fat-free mass	0.1	0.7	1.6	-0.6	-0.6	-0.2	-0.3	-1.0	0.1	1.0	-1.2	0.0	-0.8	-1.3	-1.2
Leg fat-free mass (right)	0.2	1.0	2.8	-1.0	-0.8	-0.4	-0.5	-1.5	0.3	1.1	-1.0	0.1	-1.0	-1.7	-1.4
Arm fat percentage (left)	0.4	1.5	2.7	-1.6	0.8	1.4	1.5	1.0	-1.2	0.8	-1.2	-1.4	-1.6	-0.5	-1.3
Average weekly red wine intake	0.4	0.7	2.1	0.4	1.4	1.0	0.7	0.6	-1.1	0.8	-0.8	-0.8	0.0	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.3	0.4	0.8	0.5	0.9	1.8	-0.6	-0.6	-1.0	-0.5	0.0	0.6	0.2
Mood swings	0.4	0.7	2.4	-1.5	0.2	0.4	-0.3	-0.8	-0.0	-0.4	-0.2	-0.2	-1.1	-1.5	-1.1
Loneliness, isolation	0.7	0.9	1.7	0.8	-0.8	-1.1	-0.8	-0.4	1.0	-0.4	1.3	1.1	1.1	1.0	1.1
Long-standing illness, disability or infirmity	1.5	2.3	4.9	1.4	-1.0	-1.2	-1.6	-1.8	1.1	-0.9	2.2	1.2	1.7	1.8	1.9
Ever had bowel cancer screening	0.6	0.7	1.6	-1.3	0.9	0.8	0.4	0.2	-0.6	-0.1	-1.0	-0.9	-1.0	0.1	-1.2
Diabetes diagnosed by doctor	0.3	0.5	2.4	0.1	0.6	0.8	-0.0	-1.5	-0.9	0.1	-0.1	-1.0	-0.4	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.6	0.8	0.4	-0.7	-0.8	0.3	0.3	-0.2	0.1	0.1	-0.1	-0.4
Friendships satisfaction	2.2	2.8	5.0	2.0	-1.4	-1.6	-1.0	-0.2	1.3	-0.8	1.9	1.7	2.2	2.2	2.2
Qualifications: nursing, teaching	0.2	0.3	2.7	-0.2	0.6	0.7	0.0	0.3	-0.4	-1.6	-0.5	-0.0	0.2	-0.0	-0.1
Commuting to job workplace: Walk	1.5	1.6	3.5	-1.9	1.6	1.4	0.9	0.5	-1.0	-0.6	-1.4	-1.3	-1.3	-1.1	-1.4
Eye problems/disorders: Cataract	6.0	6.9	10.5	-2.8	2.5	3.2	3.0	1.4	-3.2	-2.0	-2.3	-2.9	-2.7	-2.2	-2.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	1.3	-0.2	-0.9	-0.2	0.5	0.4	-1.2	1.3	0.9	1.3	0.9	1.5
Medication for cholesterol	1.5	2.2	4.9	0.8	-1.5	-2.1	-1.9	-2.2	1.8	-0.2	1.3	1.9	1.2	0.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.4	0.1	-1.6	-0.9	0.1	0.3	0.5	-0.7	0.4	0.5	0.4	-0.2	0.2
Back pain experienced in last month	2.4	3.4	8.1	1.5	-2.8	-2.2	-1.7	-1.7	1.8	1.1	2.1	1.8	1.8	1.4	1.8
Mineral and other dietary supplements	2.2	2.9	7.0	-1.5	2.0	2.1	1.8	2.7	-1.5	-1.0	-1.7	-1.6	-1.6	-1.2	-1.3
Breast cancer (self-reported)	2.1	2.5	6.8	0.4	-2.6	-1.9	-1.8	-1.6	2.1	1.9	1.3	2.0	0.7	-0.1	0.1
Asthma (self-reported)	0.6	1.2	8.9	-0.6	0.3	0.9	1.2	0.3	-1.2	-3.0	-0.0	-1.0	-0.5	-0.5	-0.2
Osteoporosis (self-reported)	0.2	0.2	0.9	-1.0	0.6	0.3	0.2	0.6	0.1	0.4	0.2	-0.2	-0.6	-0.4	-0.6
Osteoarthritis (self-reported)	4.2	5.5	8.0	1.9	-2.5	-2.7	-2.8	-2.6	2.6	0.3	2.3	2.5	2.4	2.2	2.1
Medication: Aspirin	0.4	0.5	1.3	0.8	-0.3	0.0	-0.6	-0.9	0.1	0.3	0.7	0.3	1.0	1.1	1.2
Medication: Gliclazide	1.3	1.5	2.4	1.1	-1.2	-1.2	-1.4	-1.5	1.2	0.2	1.2	1.1	1.3	1.3	1.4
Illnesses of father: None of the above (group 1)	2.8	3.5	7.4	-0.1	-2.5	-2.7	-2.4	-1.9	2.7	1.1	1.9	2.2	0.7	-1.2	0.2
Smoking status: Current	0.3	0.4	1.6	0.6	-1.3	-1.0	-0.1	0.9	0.7	0.1	0.6	0.7	0.5	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.7	0.0	0.1	0.2	0.4	0.0	-0.3	0.2	-0.9	-0.1	-0.5	0.2	-0.6
Whole body water mass	0.1	0.7	1.6	-0.5	-0.7	-0.4	-0.4	-1.1	0.3	1.0	-1.1	0.2	-0.7	-1.3	-1.1
Leg predicted mass (right)	0.2	1.0	2.8	-1.0	-0.8	-0.4	-0.5	-1.5	0.3	1.0	-0.9	0.1	-1.0	-1.7	-1.4
Arm fat mass (left)	0.4	1.5	2.5	-1.6	0.7	1.2	1.3	0.8	-1.1	1.1	-1.4	-1.3	-1.6	-0.8	-1.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.3	0.5	0.6	-0.0	-0.8	-0.6	0.1	-0.2	-0.7	-0.2	0.5	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	1.6	-0.8	0.4	0.2	-0.9	-0.6	0.5	-1.3	0.2	0.5	-0.3	-1.0	-0.6
Miserableness	0.2	0.4	2.4	-0.4	0.6	0.4	0.5	0.9	-0.5	-1.5	-0.2	-0.4	-0.3	-0.3	-0.1
Guilty feelings	0.2	0.4	3.2	-0.0	0.5	0.3	0.5	1.8	-0.2	-0.5	-0.2	-0.2	0.0	0.5	0.1
Wears glasses or contact lenses	0.1	0.1	0.5	0.3	0.5	0.2	0.2	0.4	-0.2	-0.1	0.1	-0.2	0.2	0.7	0.4
Ever taken oral contraceptive pill	0.8	0.9	2.4	1.1	-1.1	-0.7	-0.5	-1.5	0.1	-1.2	0.9	0.6	1.0	0.8	1.0
Hearing aid user	1.1	1.2	2.9	0.4	-1.6	-1.7	-1.1	-0.7	1.5	1.5	1.1	1.1	0.4	-0.2	0.4
Mother’s age at death	2.9	3.6	5.4	2.0	-2.0	-2.1	-2.3	-2.2	2.1	-0.2	1.9	2.3	2.0	0.9	1.7
Financial situation satisfaction	1.1	1.4	3.3	1.5	-0.8	-0.8	-0.7	-0.2	1.0	1.5	0.9	1.0	1.4	1.8	1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	-0.3	1.2	1.2	0.7	0.3	-1.1	-0.3	-0.7	-1.0	-0.5	0.2	-0.2
Commuting to job workplace: Public transport	0.1	0.2	0.4	0.3	-0.6	-0.6	-0.1	-0.6	-0.0	-0.3	0.7	0.1	0.3	-0.3	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	0.8	0.4	0.0	0.1	0.7	0.2	0.1	1.2	0.5	0.7	-0.1	0.9
Medication: Blood pressure	1.4	2.7	6.6	-0.4	1.8	2.6	2.2	2.2	-2.2	-1.3	-1.2	-2.0	-0.8	0.3	-0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.5	0.8	-1.2	-1.3	-1.4	-1.2	1.3	0.8	1.9	1.0	0.8	0.3	0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.5	5.9	0.6	-1.2	-1.3	-1.4	-2.4	1.0	1.8	0.8	1.1	0.7	0.6	0.4
High cholesterol (Self-reported)	2.3	4.1	8.9	-1.2	2.0	2.6	2.6	3.0	-2.5	-0.1	-1.7	-2.7	-1.8	-0.0	-1.1
Medication: Bendroflumethiazide	1.1	1.6	3.2	-0.5	1.6	1.6	1.7	1.4	-1.8	-1.5	-0.9	-1.5	-0.8	0.1	-0.3
Medication: Paracetamol	0.1	0.1	0.4	-0.3	-0.3	-0.5	-0.1	-0.0	0.5	0.1	0.7	0.2	-0.2	-0.7	-0.2
Medication: Lisinopril	3.8	5.0	8.0	-2.6	2.3	2.7	1.9	1.2	-2.2	-1.6	-1.9	-2.7	-2.8	-1.8	-2.4
Medication: Atorvastatin	3.0	3.7	5.9	-2.0	1.0	2.2	2.3	2.4	-2.1	-0.9	-1.9	-2.4	-2.0	-0.9	-1.8
Illnesses of father: High blood pressure	1.2	1.5	3.3	-1.0	1.8	1.6	1.2	1.3	-1.4	-0.0	-1.3	-1.1	-1.1	-0.5	-1.1
Alcohol drinker status: Never	2.1	2.5	4.1	1.5	-1.4	-1.6	-1.8	-1.6	1.7	0.1	2.0	1.5	1.6	1.5	1.7
Ever smoked	0.4	0.8	2.1	-1.1	1.0	0.6	-0.4	-0.5	0.0	1.4	-0.7	-0.4	-0.9	-1.4	-1.0
Basal metabolic rate	0.1	0.8	2.2	-1.0	-0.2	0.2	0.1	-0.6	-0.3	0.9	-1.4	-0.4	-1.2	-1.4	-1.5
Leg fat percentage (left)	1.3	4.7	9.6	-1.7	1.9	2.4	3.1	3.1	-2.5	0.2	-2.0	-2.7	-2.1	-0.2	-1.5
Arm fat-free mass (left)	0.2	0.8	2.1	-0.8	-0.4	0.0	0.5	-0.1	-0.4	1.1	-1.4	-0.5	-1.2	-1.4	-1.4
Number of operations (self-reported)	1.5	2.3	6.1	-0.1	-1.5	-1.9	-2.5	-2.2	2.1	1.0	1.4	1.5	0.6	-0.1	0.2
Average weekly beer plus cider intake	1.2	1.8	4.9	-0.1	0.9	1.1	2.2	2.1	-1.8	-1.3	-1.1	-1.7	-0.7	0.0	-0.2
Irritability	2.6	4.3	8.2	-2.9	1.8	2.4	1.8	1.3	-2.0	-0.4	-1.7	-2.2	-2.5	-2.3	-2.5
Risk taking	0.7	1.0	6.0	0.6	-1.2	-1.0	-0.5	-0.2	0.7	-2.4	0.0	0.8	0.9	0.5	0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	4.0	-0.5	0.3	0.6	0.7	0.8	-0.7	-2.0	-0.6	-0.9	-0.6	0.3	-0.5
Fractured/broken bones in last 5 years	0.6	0.8	2.8	0.8	-1.1	-1.0	-0.7	-0.3	0.8	1.7	0.5	1.1	0.8	0.1	0.5
Age started oral contraceptive pill	1.5	1.9	4.8	-0.7	1.0	1.4	2.2	1.2	-2.2	-1.2	-1.1	-1.7	-1.1	-0.8	-0.9
Diastolic blood pressure, automated reading	6.5	20.1	57.8	-3.4	5.2	5.0	5.5	7.6	-4.2	1.0	-4.0	-4.7	-4.1	-2.3	-3.4
Ever depressed for a whole week	0.2	0.2	0.9	-0.1	-0.3	-0.1	-0.7	-0.8	0.5	0.9	-0.2	0.3	0.3	0.0	0.0
Unable to work because of sickness or disability	0.6	0.8	3.7	-1.2	-0.7	-0.5	-0.5	-0.4	0.6	1.9	-0.4	0.1	-0.9	-0.5	-1.2
Commuting to job workplace: Cycle	0.4	0.4	3.5	-0.2	-0.2	-0.1	-0.5	-1.1	0.2	-1.9	0.3	0.4	0.3	-0.3	0.1
Myopia	2.5	3.6	6.1	-2.3	1.9	1.6	1.4	0.7	-1.7	0.3	-2.5	-2.0	-2.4	-2.3	-2.4
Vascular/heart problems diagnosed by doctor	4.2	11.5	20.4	3.3	-3.5	-4.5	-4.0	-3.4	4.0	1.5	2.8	4.3	3.5	1.8	2.7
Cholesterol lowering medication	2.6	3.9	10.8	-0.7	1.4	2.3	2.8	3.3	-2.5	-0.4	-2.2	-2.6	-1.3	0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.4	-0.8	-0.6	-1.0	-1.3	0.7	1.2	0.4	0.5	0.1	-0.0	-0.0
Pain experienced in last month	1.8	3.0	5.2	-1.0	2.1	2.1	2.1	1.8	-2.3	-0.1	-2.0	-2.0	-1.6	-1.0	-1.4
Supplements: Calcium	0.5	0.5	1.4	0.3	-1.2	-1.1	-0.7	-1.0	0.7	-0.6	0.3	0.8	0.5	0.0	0.3
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	-0.3	0.4	0.6	1.1	0.5	-1.0	0.2	-0.5	-0.7	-0.7	-0.9	-0.6
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.4	0.0	-0.1	0.2	-0.1	-0.6	-0.1	-0.2	-0.3	-0.1	0.1	-0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	11.4	1.7	-1.8	-1.9	-2.8	-3.4	2.0	2.0	1.5	2.3	1.9	1.2	1.5
Heart disease (siblings)	6.8	8.3	17.3	-2.0	4.2	3.9	3.4	2.8	-3.5	-1.0	-2.9	-3.2	-2.6	-1.2	-2.1
Alcohol drinker status: Previous	0.4	0.4	1.5	-0.6	0.1	0.1	0.2	0.3	-0.3	1.2	-0.6	-0.3	-0.6	-1.2	-0.8
Pack years of smoking	5.0	7.3	10.8	-3.3	2.5	2.6	2.6	1.3	-2.9	-1.1	-2.9	-3.0	-3.3	-2.9	-3.2
Impedance of whole body	0.9	4.5	13.1	-0.7	3.1	2.8	2.2	2.7	-2.2	-3.6	-0.8	-2.0	-0.6	1.1	-0.1
Leg fat mass (left)	0.8	3.3	5.1	-1.8	1.5	2.0	2.3	2.0	-1.9	0.9	-1.9	-2.2	-2.0	-0.7	-1.7
Arm predicted mass (left)	0.1	0.7	1.9	-0.7	-0.6	-0.2	0.2	-0.2	-0.1	1.1	-1.2	-0.2	-1.0	-1.4	-1.3