Hub : Genes

AZGP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0330	0.0240	2.5e-02	0.016	0.018	0.003	0.019	0.008	3.9e-03	2.5e-03	1.2e-01	0.00180	3.3e-02
2	GTEx	Brain Cerebellar Hemisphere	0.4270	0.1320	3.0e-03	0.016	NA	0.013	NA	0.017	1.2e-01	NA	1.5e-01	NA	1.2e-01
3	GTEx	Lung	0.0777	0.0337	7.2e-05	0.094	NA	0.094	NA	0.091	1.2e-07	NA	1.1e-07	NA	1.7e-07
4	ROSMAP	Brain Pre-frontal Cortex	0.0770	0.0326	8.2e-05	0.043	0.029	0.043	0.029	0.047	2.9e-06	1.2e-04	2.6e-06	0.00012	9.1e-07
5	TCGA	Prostate Adenocarcinoma	0.1119	0.0555	1.3e-05	0.028	0.049	0.040	NA	0.041	5.2e-04	6.8e-06	4.2e-05	NA	3.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.4	2.2	5.6	1.2	0.5	-1.8	0.9	-2.4
Bipolar Disorder or Schizophrenia	0.8	1.8	4.2	0.7	-0.1	-2.1	-0.6	-2.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	0.9	0.5	-0.8	0.6	-0.2
Depression (Nagel 2018)	1.3	1.9	4.2	1.2	-0.8	-2.1	0.2	-1.8
Intelligence (Savage-Jansen 2018)	1.3	4.1	7.2	1.6	-2.7	-2.6	1.8	-0.4
Neuroticism (Nagel 2018)	0.5	1.3	3.5	1.9	0.2	-1.2	1.1	-0.6
Schizophrenia (2018)	0.4	0.9	2.3	-0.1	-0.5	-1.2	-1.5	-0.7
Schizophrenia vs Biploar Disorder	1.4	1.8	6.4	-0.9	0.6	1.1	-0.2	2.5
Worry (Nagel 2018)	0.4	0.9	2.3	0.4	0.6	1.5	0.5	1.2
Alzheimer’s Disease (in mother)	6.6	7.8	19.2	-4.4	-0.7	3.0	-2.3	2.1
Alzheimer’s Disease (in father)	2.9	3.2	8.2	-2.9	-0.7	1.9	-1.8	0.6
Alzheimer’s Disease (including proxy)	9.4	13.7	32.8	-5.7	-0.8	4.3	-3.0	2.8
Crohns Disease (2017)	0.4	0.9	2.5	0.8	-1.6	-1.0	0.6	-0.1
Irritable Bowel Disease (IBD)	0.4	1.1	2.4	-1.1	-1.6	-1.0	-0.9	0.3
Ulcerative Colitis (UC)	0.9	1.8	5.2	-2.3	-1.1	-0.0	-1.2	0.9
Major Depression (MDD)	1.6	2.0	5.5	-1.9	-0.8	0.2	-2.3	0.5
Reaction Time	0.6	1.2	2.1	1.3	-1.4	-1.4	0.3	-0.3
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.1	2.0	-2.7	-1.5	1.8	0.3
Breast Cancer	3.6	8.7	10.8	3.1	-3.2	-3.3	1.4	-3.2
Ovarian Cancer	0.8	1.0	2.4	-0.1	-1.5	-0.3	0.5	1.6
Prostate Cancer	0.8	1.2	3.4	-0.2	-0.2	1.8	-0.0	1.5
Age at First Birth	0.7	0.9	2.4	-0.4	1.2	-0.1	0.8	-1.5
Bipolar Disorder (2011)	0.5	0.5	1.1	0.2	-1.0	-0.5	-0.4	-1.1
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	0.8	0.6	-1.5	0.1	0.1
Coronary Artery Disease (CAD)	1.3	1.6	4.8	1.1	-0.6	-2.2	0.3	-1.1
Crohns Disease (2012)	0.6	0.9	2.8	0.8	-1.7	-0.2	0.8	0.7
Mean Putamen Volume	1.8	2.1	6.5	-0.3	-2.5	-1.5	-0.3	1.3
Fasting Glucose	0.4	0.5	1.6	0.0	1.3	-0.3	0.1	-0.8
HbA1C	3.5	3.9	14.3	-0.0	3.8	1.1	1.9	-0.5
HDL Cholesterol	0.9	1.5	6.1	0.1	2.5	1.1	0.5	-0.2
LDL Cholesterol	1.1	1.8	5.0	0.8	0.6	-1.7	0.0	-2.2
Lupus	0.2	0.3	0.7	-0.3	-0.4	0.6	0.0	0.8
Neuroticism (2016)	0.5	0.7	1.9	0.5	0.7	-0.7	-0.6	-1.4
Primary Biliary Cirrhosis	0.7	0.9	2.8	1.2	0.3	0.2	1.7	0.4
Rheumatoid Arthritis	2.5	3.4	10.4	-1.5	3.2	1.8	-1.0	-0.3
Schizophrenia (2014)	0.3	0.7	2.0	-0.2	-1.1	-0.7	-1.4	-0.2
Triglycerides	1.2	1.9	6.6	0.9	-2.6	-1.5	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.8	-0.2	1.2	1.3	-0.0	1.2
Ulcerative Colitis	1.4	2.1	5.7	-2.4	-0.9	0.3	-1.5	1.3
Blood Eosinophil Count	0.2	1.9	7.0	-0.3	2.6	0.9	1.2	-0.2
Blood Platelet Count	3.5	40.9	77.4	-7.8	3.9	5.4	-8.8	4.6
Blood Red Count	3.4	32.7	79.6	2.6	-8.9	1.4	7.4	4.6
Blood White Count	0.2	1.4	4.5	-0.9	0.9	0.8	-0.7	2.1
Heel T-Score	1.2	9.5	20.3	2.5	-4.2	-1.2	4.5	-1.2
BMI	0.8	4.8	10.4	-2.5	-0.1	0.6	-3.2	2.7
Height	0.2	3.1	11.9	-0.7	0.1	-3.5	-1.8	-0.4
Waist Hip Ratio (WHR)	0.8	3.7	15.4	0.3	-3.9	-1.2	0.0	1.2
Systolic Blood Pressure	0.3	1.4	2.6	1.1	-1.6	-0.7	1.6	0.3
Smoking Status	0.2	0.5	1.7	0.3	-0.3	0.3	-1.3	0.7
Allergy or Eczema	1.2	3.2	10.5	-0.8	3.2	1.3	1.7	0.6
Cardiovascular Disease	1.6	5.4	14.8	1.8	-3.9	-3.0	0.1	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.0	-0.5	-0.9	0.5	0.1
Respiratory disease	0.8	1.8	4.6	2.2	0.5	-0.5	2.0	0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.7	1.3	-1.0	-0.6	1.3	1.1
Lung FEV1/FVC ratio	9.5	48.4	97.4	-9.9	-1.7	5.5	-9.8	3.8
Lung FVC	1.2	6.1	12.8	2.5	1.0	-2.9	1.4	-3.6
Neuroticism	0.2	0.6	1.4	1.2	0.9	0.3	0.7	-0.1
Chronotype (morning person)	0.4	0.9	2.7	0.4	1.6	0.1	1.1	-0.7
Hair Pigment	0.2	4.4	8.1	-2.9	1.3	1.2	-2.7	1.9
Tanning	0.2	3.0	5.7	-1.6	2.4	0.9	-2.4	0.4
Hand grip strength (left)	1.4	3.6	6.8	0.1	-2.3	-2.6	-1.2	-2.1
Number of treatments/medications taken	0.5	0.8	1.7	1.0	-1.3	0.2	1.1	0.3
Average weekly spirits intake	0.7	0.9	2.2	-0.7	0.2	1.2	-0.6	1.5
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.9	-0.1	0.5	-1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	0.5	-0.1	-1.4	-0.4	-0.7
Hearing difficulty/problems: Yes	0.5	0.8	1.5	-0.5	-0.9	-1.2	-1.2	-0.2
Relative age of first facial hair	1.1	2.4	5.7	0.0	0.7	-2.4	-2.0	-1.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	5.6	0.9	1.5	1.5	2.4	1.2
Ever used hormone-replacement therapy (HRT)	1.9	2.5	6.6	-1.5	1.1	1.1	-2.6	1.0
Ever had hysterectomy (womb removed)	1.9	2.1	3.7	-1.9	0.8	1.8	-1.1	1.3
Systolic blood pressure, automated reading	0.2	0.6	2.2	0.1	-1.5	-0.1	0.9	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	-0.3	0.4	0.6	-0.2	1.1
Angina	0.8	1.1	3.6	1.9	-0.2	0.0	1.1	-0.9
Medication for hormone replacement therapy	0.7	0.8	1.7	0.1	0.8	0.7	-1.3	1.0
Vitamin and mineral supplements	1.6	2.2	7.9	-0.0	-2.8	-1.3	-1.1	-0.2
Supplements: Zinc	0.7	0.7	1.6	0.7	1.2	-1.2	-0.2	-0.0
Medication: Co-codamol	0.6	0.6	2.2	0.2	1.5	0.8	0.5	0.3
Medication: Metformin	0.2	0.2	0.7	-0.1	-0.5	-0.4	-0.0	0.8
Diabetes (father)	0.5	0.6	1.8	0.8	0.1	-0.2	1.3	-0.8
Diabetes (mother)	0.8	1.1	3.7	-0.6	-0.2	1.1	-0.3	1.9
Severe depression (siblings)	0.8	0.9	3.6	-0.6	-1.9	0.4	-0.2	0.4
Pack years adult smoking proportion	1.3	2.0	6.4	1.5	-1.0	-2.5	0.4	-0.6
Impedance of leg (right)	2.5	12.2	20.5	4.5	-3.0	-3.2	3.9	-2.5
Leg fat-free mass (left)	1.4	7.4	17.1	-3.8	1.1	0.5	-4.1	2.0
Trunk fat percentage	0.6	2.4	5.1	-0.9	-2.2	-2.3	-0.9	-0.3
Hand grip strength (right)	1.0	2.6	5.7	0.9	-2.4	-2.1	-0.9	-1.3
Townsend deprivation index at recruitment	0.9	1.2	2.4	1.2	-0.8	-1.1	-0.3	-1.5
Current tobacco smoking	0.4	0.6	1.5	0.5	0.5	1.1	0.1	1.2
Average weekly fortified wine intake	0.5	0.6	1.2	0.8	1.1	0.0	0.5	-1.1
Maternal smoking around birth	1.4	2.0	4.4	1.3	1.5	-2.1	-0.4	-1.2
Fed-up feelings	1.3	2.4	4.0	-1.6	2.0	1.9	-1.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	0.4	-1.0	-1.3	-0.4	-1.2
Relative age voice broke	0.7	1.0	2.7	-0.3	0.1	-1.6	-1.1	-1.0
Taking other prescription medications	1.6	2.4	6.5	1.5	1.5	-0.2	2.6	-1.0
Age when periods started (menarche)	2.4	5.7	16.1	-0.3	0.1	-4.0	-1.6	-3.2
Bilateral oophorectomy (both ovaries removed)	4.6	5.4	8.9	-3.0	2.1	3.0	-1.5	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	8.9	0.8	-3.0	-1.1	1.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.8	-1.2	0.9	1.3	-0.1	0.8
Qualifications: CSEs or equivalent	0.3	0.4	1.4	0.4	0.0	0.6	-1.2	0.5
Serious illness, injury or assault to yourself	1.5	1.9	3.2	-0.9	1.8	1.5	-1.0	1.4
High blood pressure	1.8	4.9	8.8	2.4	-2.8	-3.0	1.3	-0.8
Hayfever, allergic rhinitis or eczema	1.2	2.6	9.2	-1.1	3.0	1.4	0.4	0.9
Multivitamins +/- minerals	1.9	2.5	8.7	-0.9	3.0	1.5	0.1	0.8
Stomach or abdominal pain in last month	2.1	2.7	5.7	-0.1	2.2	2.4	1.0	1.4
Supplements: Glucosamine	0.7	0.9	1.8	-1.2	1.3	0.8	0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.1	-1.4	0.8	1.2	-0.8	0.4
Medication: Atenolol	1.3	1.6	4.8	0.1	-1.2	-1.4	0.2	-2.2
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.8	-0.4	0.3	0.5	0.4
Sitting height	0.4	2.5	4.2	-2.0	1.3	1.1	-1.6	1.8
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	0.7	0.8	0.1	-0.2	-1.0
High blood pressure (mother)	0.5	0.7	1.8	0.1	0.5	-1.1	-0.0	-1.3
Body mass index (BMI)	1.2	5.2	11.7	-3.2	-0.8	0.4	-3.4	1.8
Impedance of leg (left)	2.7	13.3	24.5	4.9	-3.4	-3.4	3.7	-2.3
Leg predicted mass (left)	1.4	7.4	17.1	-3.8	1.1	0.4	-4.1	2.0
Trunk fat mass	0.6	2.6	4.0	-1.6	-1.7	-2.0	-1.8	0.3
Waist circumference	1.2	4.2	6.7	-2.5	-1.9	-0.4	-2.6	2.1
Number of incorrect matches in round	1.0	1.6	4.2	-0.4	-1.5	-1.2	0.1	-2.1
Past tobacco smoking	0.2	0.3	0.6	-0.7	0.2	0.8	0.4	0.4
Alcohol usually taken with meals	0.1	0.2	0.9	0.2	-0.1	0.4	-0.2	0.9
Nervous feelings	0.3	0.5	1.4	1.0	0.0	0.1	1.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	-0.9	-1.0	-0.4	-0.6	-0.3
Hearing difficulty/problems with background noise	0.5	0.9	1.5	0.7	-1.2	-1.2	-0.1	1.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.3	1.2	-0.6	-1.0	0.9	0.0
Had menopause	1.3	1.6	3.1	-1.5	1.6	0.5	-1.8	0.0
Had other major operations	6.2	7.6	11.3	-3.0	1.5	3.1	-2.4	3.4
Forced vital capacity (FVC)	0.3	1.1	3.5	-0.5	-0.4	-1.2	-1.9	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	7.7	1.1	-2.8	-1.9	2.1	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-1.4	0.1	0.7	-0.9	-0.5
Qualifications: None of the above	0.4	0.9	3.1	-0.4	0.9	0.2	-1.8	-0.5
Financial difficulties in last 2 years	0.1	0.2	0.3	0.4	0.4	0.5	-0.3	0.5
Mouth/teeth dental problems	1.0	1.5	3.5	-1.4	-1.1	-0.8	-1.9	0.7
Heart attack	0.7	1.0	3.3	1.8	0.1	-0.0	1.1	-0.5
Allergy	1.1	2.5	8.5	0.5	-2.9	-1.5	-0.8	-0.8
Pain all over the body in last month	0.9	1.0	2.1	-1.4	0.9	-0.4	-1.4	-0.1
Diabetes (self-reported)	0.4	0.6	1.2	0.7	-0.9	-0.1	0.7	1.1
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	17.0	-1.7	4.1	2.5	-0.5	0.2
Medication: Ramipril	0.0	0.1	0.2	0.0	0.2	0.5	0.1	0.1
Medication: Simvastatin	1.9	2.8	10.5	0.6	-3.2	-1.8	-0.3	0.3
Fluid intelligence score	2.2	4.6	9.9	2.3	-3.1	-1.9	2.0	-0.5
Illnesses of siblings	3.9	5.5	15.5	-1.4	3.9	3.0	-0.4	1.0
Neuroticism score	0.1	0.2	0.4	0.6	0.5	0.3	0.2	0.2
Weight	1.1	5.3	12.6	-3.0	-0.8	-0.8	-3.5	1.9
Impedance of arm (right)	2.3	10.7	17.7	3.5	-2.0	-3.3	4.2	-3.0
Arm fat percentage (right)	0.5	2.0	4.0	-2.0	-1.3	-0.8	-2.0	0.2
Trunk fat-free mass	1.2	7.0	14.9	-3.4	1.4	0.9	-3.9	2.5
Hip circumference	0.8	3.6	8.6	-2.5	-0.3	-0.5	-2.9	1.7
Time employed in main current job	1.5	1.8	5.0	2.2	-0.1	-0.6	1.9	-0.1
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.5	1.2	-0.7	0.1	-0.8
Father’s age at death	2.8	3.8	6.9	-2.6	1.9	2.6	-1.3	0.1
Worrier / anxious feelings	0.4	0.8	2.1	1.0	-1.4	-0.7	0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	-0.5	0.3	0.5	-0.4	1.1
Falls in the last year	1.5	2.1	4.8	-2.2	0.2	1.6	-1.2	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	1.6	-1.2	1.2	1.2	-0.6	1.3
Number of live births	0.5	0.7	1.3	1.0	-0.7	-0.8	0.1	1.1
Forced expiratory volume in 1-second (FEV1)	2.5	8.3	22.5	-3.7	-0.6	1.0	-4.7	2.0
Pulse rate	1.7	2.8	8.0	0.4	-1.6	-2.8	-1.9	-0.3
Happiness	0.2	0.2	0.6	-0.3	0.6	0.8	-0.3	0.1
Noisy workplace	2.0	2.4	6.5	-2.1	-0.3	0.7	-2.5	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.0	0.4	-1.7	-0.2	1.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.7	1.2	0.5	1.0	2.4	-0.3
Mouth/teeth dental problems: Dentures	0.7	1.2	5.4	0.2	2.3	0.7	0.3	-0.1
Asthma	0.5	1.0	2.3	1.5	-0.1	-0.7	1.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.4	-0.5	-0.1	0.8	-0.8
Medication: Cholesterol lowering	2.3	3.6	8.0	2.0	-1.7	-2.8	0.6	-1.6
Depression (self-reported)	0.6	0.7	1.6	-0.8	1.2	-0.4	-1.3	-0.1
Medication: Lansoprazole	0.9	1.0	2.3	-1.3	-1.0	1.5	0.3	0.3
Prospective memory result	0.6	0.7	1.8	-1.4	0.3	1.1	-0.6	-0.0
Lung cancer (father)	3.1	3.6	5.7	-2.4	1.3	2.3	-1.6	1.7
Illnesses of mother	1.6	2.0	5.3	0.4	1.1	2.3	0.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	14.6	-2.9	0.0	1.1	-3.8	1.6
Pulse wave Arterial Stiffness index	1.1	1.3	2.9	-0.3	-1.6	-0.2	-1.7	0.7
Impedance of arm (left)	3.0	14.1	23.8	4.2	-1.9	-3.6	4.9	-3.5
Arm fat mass (right)	1.1	4.4	10.4	-2.8	-1.1	-0.4	-3.2	1.5
Trunk predicted mass	1.2	7.1	14.7	-3.3	1.4	1.0	-3.8	2.6
Standing height	0.1	1.2	4.8	-0.1	-0.3	-2.2	-0.7	0.8
Length of working week for main job	0.4	0.4	1.1	-0.3	0.3	1.1	-0.2	0.9
Exposure to tobacco smoke at home	2.0	2.2	6.3	-1.6	2.5	1.4	-0.2	0.2
Breastfed as a baby	0.7	0.9	2.1	-0.7	-0.5	1.2	0.3	1.4
Tense / ‘highly strung’	0.1	0.2	0.9	0.1	-0.2	0.0	-0.9	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	0.0	-0.7	-0.6	0.3
Hair/balding pattern: Pattern 4	1.0	2.4	8.3	-1.2	-2.9	1.0	-0.9	0.8
Birth weight of first child	3.7	6.6	12.1	-3.3	-3.1	0.1	-3.5	0.7
Peak expiratory flow (PEF)	3.3	7.6	19.3	-4.4	0.6	1.6	-3.9	0.8
Pulse wave reflection index	0.8	1.0	4.3	-0.2	-2.1	-0.2	0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.5	-0.7	-0.4	-0.5	-0.1
Loud music exposure frequency	0.2	0.3	0.9	1.0	-0.6	0.1	0.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	0.2	-0.8	-0.2	1.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.5	-0.5	0.9	0.4	0.8
Blood clot in the leg (DVT)	1.6	2.1	4.1	-2.0	1.9	1.3	-0.9	0.4
Medication: Paracetamol	0.1	0.1	0.2	0.5	0.2	-0.2	-0.2	0.4
Headache pain in last month	0.1	0.1	0.2	0.5	-0.1	0.1	0.4	0.4
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	10.5	-2.5	1.8	3.2	-0.5	1.5
Glaucoma (self-reported)	1.0	1.2	5.5	0.2	-2.3	-0.5	0.1	-0.6
Gout (self-reported)	0.9	1.2	2.0	-1.4	-0.7	-0.7	-1.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	-0.4	0.0	-0.4	0.8	0.1
Medication: Amlodipine	0.6	0.8	3.4	0.1	-1.8	0.6	0.0	0.4
Medication: Ventolin 100micrograms inhaler	2.0	2.6	6.0	2.5	0.2	-1.9	1.8	-0.2
Birth weight	0.8	1.6	4.7	-1.0	0.3	-2.2	-1.6	-0.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	0.3	0.1	-1.4	0.5	-1.1
High blood pressure (siblings)	1.4	2.0	6.4	0.2	-2.5	-1.7	0.3	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	0.2	0.3	-1.0	-1.3	0.2
Body fat percentage	0.6	2.3	4.6	-1.1	-2.2	-2.0	-1.3	-0.2
Leg fat percentage (right)	0.8	3.0	8.7	-0.8	-3.0	-1.7	-1.5	-0.3
Arm fat-free mass (right)	1.4	7.3	16.8	-3.4	0.8	0.8	-4.1	2.6
Exposure to tobacco smoke outside home	0.6	0.9	2.7	-0.6	1.6	-0.6	-0.7	-0.6
Comparative body size at age 10	0.4	1.2	2.8	0.8	0.2	-1.2	1.2	-1.7
Number of full brothers	0.9	1.2	3.1	1.3	-1.0	-1.8	0.1	0.1
Worry too long after embarrassment	0.5	0.9	2.4	1.5	-0.7	-1.2	0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.8	1.0	0.8	-1.3	-0.7	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.3	0.1	-0.6	-0.4	-0.4
Number of children fathered	1.0	1.1	3.0	-0.4	1.7	1.2	0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.9	1.8	-2.4	-1.8	1.3	0.4
Age at first live birth	0.1	0.2	0.6	-0.3	-0.3	-0.0	0.8	-0.6
Pulse wave peak to peak time	1.0	1.2	2.9	0.3	1.7	0.0	1.6	-0.7
Health satisfaction	0.2	0.2	0.6	-0.1	-0.3	0.1	0.8	0.5
Shortness of breath walking on level ground	0.2	0.2	0.6	0.3	0.8	-0.5	0.5	-0.1
Qualifications: College or University degree	1.7	5.3	14.0	2.6	-0.7	-1.9	3.7	-1.3
Eye problems/disorders: None of the above	2.0	2.3	4.7	-1.3	-0.7	1.3	-2.2	1.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.2	1.0	-0.9	-0.4	0.4	-1.8
Emphysema/chronic bronchitis	0.5	0.6	2.0	0.7	-0.3	-1.4	-0.2	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.4	1.0	-0.8	-0.4	-0.8
Neck or shoulder pain in last month	1.6	2.2	9.4	-0.4	3.1	1.1	-0.3	0.5
Medication: Blood pressure	1.6	2.8	6.1	2.2	-1.4	-2.5	0.9	-0.6
Angina (self-reported)	0.9	1.1	3.1	1.8	-0.2	0.1	1.1	-1.1
Migraine (self-reported)	1.2	1.4	3.6	-1.9	0.0	1.4	-1.0	0.7
Medication: Ibuprofen	0.3	0.3	0.8	0.4	-0.1	-0.2	0.7	-0.9
Medication: Allopurinol	0.7	0.9	2.1	-1.5	-0.4	-0.1	-1.2	-0.9
Medication: Omeprazole	1.2	1.4	2.9	-1.7	0.4	1.0	-1.7	0.4
Medication: Seretide 50 evohaler	2.3	2.6	6.1	2.0	2.5	-0.9	1.2	-0.9
Mean time to correctly identify matches	0.9	1.8	3.6	1.9	-1.2	-1.6	1.1	0.1
Heart disease (mother)	3.5	4.3	7.6	2.8	-2.4	-2.1	1.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	-1.0	0.5	1.2	-0.3	0.2
Whole body fat mass	0.8	3.2	6.8	-2.1	-1.6	-1.3	-2.6	0.9
Leg fat mass (right)	0.9	3.5	7.6	-2.0	-2.0	-1.2	-2.8	0.8
Arm predicted mass (right)	1.2	6.3	14.3	-3.1	0.6	0.6	-3.8	2.6
Pulse rate, automated reading	3.6	11.6	26.6	-0.1	-4.4	-5.2	-3.5	-0.4
Alcohol intake frequency.	1.9	4.3	7.6	-2.5	2.8	2.8	-0.3	0.3
Comparative height size at age 10	0.2	1.1	2.4	-1.1	0.9	0.1	-1.2	1.5
Number of full sisters	1.4	1.7	3.5	1.0	-1.3	-1.9	-0.1	-1.5
Suffer from ‘nerves’	0.9	1.5	4.6	-1.0	0.8	2.1	-0.6	0.9
Overall health rating	1.1	2.4	6.6	-1.1	0.2	2.0	-0.7	2.6
Chest pain or discomfort	0.7	1.1	3.2	1.8	-0.5	-0.5	0.7	1.1
Had major operations	1.1	1.3	3.6	0.2	1.9	1.0	1.1	0.8
Age at last live birth	1.2	1.8	3.5	0.4	-1.3	-1.4	1.3	-1.9
Family relationship satisfaction	0.1	0.2	0.4	0.1	-0.2	0.6	-0.6	-0.1
Leg pain on walking	2.3	2.9	6.6	-1.4	-0.7	2.6	-0.1	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.3	-1.0	1.8	1.8	-0.7	1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	-0.1	1.2	0.6	0.1	0.2
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.7	0.9	-1.5	-2.2	0.2	-1.3
Medication: Aspirin	0.9	1.2	5.7	-0.1	-2.4	0.2	-0.6	-0.2
Supplements: Vitamin C	0.5	0.6	1.4	0.8	-0.3	0.0	1.2	0.9
Knee pain experienced in last month	1.9	3.0	4.5	-2.1	1.6	1.6	-1.2	2.1
Hypertension (Self-reported)	1.8	4.9	9.3	2.2	-2.9	-3.1	1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	7.1	-1.4	1.4	2.7	-0.8	2.2
Illnesses of father: Heart disease	1.8	2.5	4.7	0.6	-2.2	-1.8	-0.0	-2.1
Illnesses of siblings: Diabetes	0.9	1.1	2.7	-0.8	-0.5	1.3	0.6	1.6
Smoking status: Previous	0.3	0.4	1.2	0.1	0.1	-1.1	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	0.3	0.4	-0.2	-1.3	0.3
Whole body fat-free mass	1.3	7.3	16.4	-3.5	1.2	0.7	-4.0	2.4
Leg fat-free mass (right)	1.4	7.6	16.8	-3.7	1.3	0.7	-4.1	2.3
Arm fat percentage (left)	0.5	2.0	3.7	-1.9	-1.5	-0.9	-1.8	0.2
Average weekly red wine intake	0.8	1.1	4.2	-0.5	-2.0	-1.0	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.8	0.5	-2.2	-0.8	-1.4	1.2
Mood swings	0.3	0.5	1.3	-0.3	1.2	-0.1	-0.9	0.5
Loneliness, isolation	0.1	0.1	0.3	-0.1	0.1	0.5	-0.3	-0.4
Long-standing illness, disability or infirmity	1.6	2.5	8.1	1.7	0.8	1.0	2.9	-0.5
Ever had bowel cancer screening	0.5	0.6	1.0	-0.5	0.5	-1.0	-0.6	-0.9
Diabetes diagnosed by doctor	0.5	0.9	2.1	0.5	-1.4	-0.3	0.3	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	0.6	0.5	-1.0	1.2	-0.4
Friendships satisfaction	0.3	0.4	1.2	0.1	-0.4	1.1	0.4	0.6
Qualifications: nursing, teaching	0.8	1.3	2.6	0.8	0.4	-0.8	1.6	-1.5
Commuting to job workplace: Walk	1.2	1.3	2.4	0.3	-0.5	-1.6	1.2	-1.5
Eye problems/disorders: Cataract	3.7	4.3	9.5	2.4	-0.1	-3.1	2.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.9	1.6	-0.8	-0.5	2.2	-1.9
Medication for cholesterol	0.8	1.3	5.9	0.2	2.4	-0.0	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.4	-0.3	1.1	0.9	-1.0	1.6
Back pain experienced in last month	2.6	3.9	9.9	-0.6	0.7	3.1	-0.2	2.9
Mineral and other dietary supplements	2.1	2.9	7.4	0.8	-2.7	-1.8	-1.2	1.3
Breast cancer (self-reported)	4.6	5.4	8.3	-2.6	2.6	2.9	-1.8	1.5
Asthma (self-reported)	0.6	1.2	2.6	1.6	0.3	-0.8	1.6	-0.5
Osteoporosis (self-reported)	0.4	0.5	0.8	0.9	0.9	-0.5	0.3	-0.6
Osteoarthritis (self-reported)	1.4	1.8	4.9	-1.5	0.6	2.2	-0.7	1.0
Medication: Aspirin	0.8	1.1	4.1	-0.4	-2.0	0.9	-0.5	0.4
Medication: Gliclazide	0.4	0.5	0.9	-0.7	-0.6	1.0	-0.2	0.9
Illnesses of father: None of the above (group 1)	4.2	5.2	10.5	-1.2	3.2	2.3	-0.7	2.9
Smoking status: Current	0.7	1.1	3.0	0.4	0.3	1.5	-0.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	11.9	-1.5	-0.7	-0.7	-3.4	0.1
Whole body water mass	1.4	8.0	18.0	-3.7	1.3	0.8	-4.2	2.5
Leg predicted mass (right)	1.4	7.5	16.6	-3.6	1.3	0.7	-4.1	2.4
Arm fat mass (left)	1.0	4.2	9.5	-2.8	-1.4	-0.6	-3.1	1.4
Number of self-reported non-cancer illnesses	0.5	0.9	2.7	0.8	-0.1	-0.2	1.6	-1.0
Average weekly champagne plus white wine intake	0.7	1.0	1.6	1.1	1.3	-1.1	0.2	1.0
Miserableness	0.5	0.9	2.4	1.6	-1.2	-0.6	0.3	-0.6
Guilty feelings	0.4	0.6	1.7	1.3	-0.8	0.2	0.6	0.0
Wears glasses or contact lenses	1.0	1.1	2.6	0.8	-0.5	-1.1	0.9	-1.6
Ever taken oral contraceptive pill	0.6	0.6	1.9	1.4	0.4	0.7	0.8	0.1
Hearing aid user	1.4	1.6	2.9	-1.4	1.7	1.6	-0.6	0.2
Mother’s age at death	0.4	0.5	1.0	-0.7	0.9	1.0	0.4	-0.1
Financial situation satisfaction	1.1	1.4	1.9	-1.4	0.5	1.2	-1.4	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.7	1.2	-0.8	-1.3	0.8	-0.3
Commuting to job workplace: Public transport	0.7	0.9	2.1	1.2	0.9	0.3	1.4	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.9	1.3	-2.0	-0.2	0.2	-0.1
Medication: Blood pressure	1.2	2.3	8.7	1.0	-3.0	-0.9	1.1	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	0.1	0.7	1.6	0.8	1.3
Supplements: Fish oil (including cod liver oil)	2.2	2.8	8.1	-1.6	2.8	1.3	0.7	-1.1
High cholesterol (Self-reported)	0.9	1.6	4.4	0.8	-2.1	-1.4	0.8	0.6
Medication: Bendroflumethiazide	1.5	2.3	8.2	0.1	-2.9	-1.6	-0.5	0.5
Medication: Paracetamol	0.1	0.2	0.5	0.4	0.4	0.1	-0.3	0.7
Medication: Lisinopril	1.3	1.7	4.9	0.9	-1.2	-2.2	-1.1	-0.2
Medication: Atorvastatin	1.9	2.4	7.7	1.5	1.0	0.0	2.8	-1.1
Illnesses of father: High blood pressure	1.3	1.6	3.4	1.0	-0.4	-1.9	-0.1	-1.8
Alcohol drinker status: Never	1.4	1.7	4.9	0.5	1.1	1.2	2.2	-0.8
Ever smoked	0.1	0.2	0.6	0.8	0.3	0.2	-0.2	0.6
Basal metabolic rate	1.3	7.0	17.0	-3.5	0.7	0.3	-4.1	2.4
Leg fat percentage (left)	0.8	3.0	8.9	-0.7	-3.0	-1.6	-1.7	0.0
Arm fat-free mass (left)	1.6	7.9	19.9	-3.5	0.7	0.7	-4.5	2.6
Number of operations (self-reported)	2.1	3.1	7.0	-1.4	2.6	2.0	-0.1	1.6
Average weekly beer plus cider intake	1.8	2.6	4.1	1.9	-2.0	-0.7	1.9	0.9
Irritability	1.1	1.9	3.0	1.4	0.5	-1.3	1.7	-1.7
Risk taking	0.3	0.4	1.1	0.5	0.3	0.5	-0.5	1.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.2	1.5	0.3	-0.5	2.3	-1.6
Fractured/broken bones in last 5 years	1.9	2.4	4.9	-2.2	1.3	2.0	-1.0	0.6
Age started oral contraceptive pill	2.4	3.1	6.1	2.2	-0.5	-1.5	2.5	-1.3
Diastolic blood pressure, automated reading	1.3	3.9	9.3	0.4	-3.0	-3.0	-0.2	-0.9
Ever depressed for a whole week	0.3	0.3	0.6	-0.6	0.8	0.6	-0.4	0.2
Unable to work because of sickness or disability	1.5	2.0	3.9	-2.0	1.6	1.1	-1.4	0.1
Commuting to job workplace: Cycle	0.8	1.0	3.7	1.9	-0.1	-0.8	0.5	0.7
Myopia	1.4	2.0	6.0	0.4	0.8	-1.8	0.3	-2.4
Vascular/heart problems diagnosed by doctor	1.5	4.2	8.7	-2.3	3.0	2.4	-0.9	0.3
Cholesterol lowering medication	1.0	1.4	5.7	-0.1	-2.4	-0.3	1.1	0.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.2	-1.4	0.8	1.5	-1.3	0.5
Pain experienced in last month	1.4	2.3	6.1	1.3	-0.7	-1.6	1.0	-2.5
Supplements: Calcium	1.0	1.1	2.3	-1.3	0.6	0.6	-0.9	-1.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	0.7	0.2	-0.3	-0.0	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	1.5	0.2	-0.0	1.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.9	-2.2	2.0	1.7	-0.7	0.4
Heart disease (siblings)	7.2	8.8	21.4	2.0	-3.6	-4.6	-0.7	-2.2
Alcohol drinker status: Previous	0.9	1.0	2.8	-1.1	-0.4	0.7	-0.7	1.7
Pack years of smoking	1.6	2.4	7.7	1.7	-0.3	-2.8	0.5	-1.1
Impedance of whole body	2.9	14.8	22.2	4.7	-2.4	-3.7	4.6	-3.3
Leg fat mass (left)	0.9	3.7	8.4	-1.9	-2.0	-1.2	-2.9	1.0
Arm predicted mass (left)	1.6	8.1	19.8	-3.5	0.7	0.8	-4.5	2.8