Hub : Genes

GPC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.244 0.116 8.3e-03 0.016 NA 0.077 NA 0.021 1.2e-01 NA 5.2e-03 NA 9.2e-02
2 GTEx Brain Cerebellum 0.285 0.141 6.0e-03 0.306 NA 0.304 NA 0.294 1.0e-09 NA 1.2e-09 NA 2.3e-09
3 GTEx Esophagus Mucosa 0.075 0.039 9.5e-03 0.027 NA 0.022 NA -0.003 6.6e-03 NA 1.2e-02 NA 5.4e-01
4 GTEx Skin Not Sun Exposed Suprapubic 0.153 0.057 7.0e-06 0.106 NA 0.113 NA 0.091 2.0e-06 NA 9.1e-07 NA 1.1e-05
5 GTEx Skin Sun Exposed Lower leg 0.073 0.031 1.8e-04 0.070 NA 0.038 NA -0.002 2.0e-06 NA 4.0e-04 NA 5.8e-01
6 TCGA Pancreatic Adenocarcinoma 0.134 0.078 6.0e-03 0.007 0.041 0.012 NA 0.013 1.6e-01 0.0077 1.0e-01 NA 8.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.9 3.1 6.1 0.1 0.6 -1.8 -2.5 -2.3 1.8
Bipolar Disorder or Schizophrenia 0.8 2.1 4.3 -0.4 0.4 -1.4 -2.1 -1.7 1.7
Depressed Affect (Nagel 2018) 1.2 2.5 7.2 -2.1 -2.7 -1.4 -0.8 -0.8 -0.5
Depression (Nagel 2018) 0.8 1.2 2.2 -0.6 -1.0 -1.5 -1.4 -1.1 0.8
Intelligence (Savage-Jansen 2018) 0.7 2.3 7.3 -2.2 -1.1 -0.3 0.3 0.1 2.7
Neuroticism (Nagel 2018) 1.7 3.9 10.8 -2.0 -3.3 -2.1 -1.5 -1.3 0.2
Schizophrenia (2018) 0.1 0.3 0.5 -0.6 -0.0 -0.4 -0.7 -0.3 0.7
Schizophrenia vs Biploar Disorder 1.3 1.7 3.2 -0.7 -0.7 0.9 1.6 1.7 -1.8
Worry (Nagel 2018) 0.3 0.6 1.7 0.4 -1.3 -0.3 -0.3 -0.3 -1.2
Alzheimer’s Disease (in mother) 12.0 14.0 18.4 3.5 3.8 4.2 4.3 3.9 -2.4
Alzheimer’s Disease (in father) 3.2 3.5 5.9 1.5 0.8 2.1 2.3 2.4 -1.6
Alzheimer’s Disease (including proxy) 16.9 24.5 37.2 4.1 4.0 5.7 6.1 5.5 -3.7
Crohns Disease (2017) 0.3 0.6 2.6 -0.6 0.8 -0.2 -0.4 -0.1 1.6
Irritable Bowel Disease (IBD) 0.8 2.0 3.9 -0.7 0.5 -1.3 -2.0 -1.6 1.8
Ulcerative Colitis (UC) 0.8 1.5 3.7 -0.0 0.7 -1.0 -1.9 -1.5 1.2
Major Depression (MDD) 0.8 1.0 2.6 1.2 0.7 -0.2 -1.6 -1.2 -0.2
Reaction Time 0.2 0.4 1.1 0.2 0.1 -0.7 -0.9 -0.5 1.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 8.4 -1.7 -0.5 0.7 0.3 0.9 2.9
Breast Cancer 1.1 2.7 11.8 -1.6 -1.0 -0.3 0.0 0.9 3.4
Ovarian Cancer 0.4 0.5 1.6 -0.7 -1.3 0.4 0.3 0.6 0.5
Prostate Cancer 0.7 1.0 2.2 1.5 0.9 1.4 0.5 0.8 -0.2
Age at First Birth 0.2 0.3 1.1 -0.6 -1.1 0.4 -0.5 0.2 -0.3
Bipolar Disorder (2011) 1.7 1.6 3.4 -1.0 -1.3 -0.4 -1.8 -1.1 1.6
Body Mass Index (BMI) (2010) 0.7 0.9 1.9 -0.6 -1.0 -1.1 -1.4 -1.1 0.2
Coronary Artery Disease (CAD) 1.4 1.6 3.7 -0.7 -0.4 -1.9 -1.6 -1.0 1.4
Crohns Disease (2012) 1.3 2.2 3.8 0.7 1.8 1.6 1.3 2.0 1.1
Mean Putamen Volume 2.5 2.9 6.5 -1.9 -2.2 -1.1 -0.9 -0.7 2.5
Fasting Glucose 0.8 1.0 2.0 -1.4 -1.2 -1.1 -0.5 -0.9 0.2
HbA1C 1.7 1.8 4.5 2.1 2.0 -1.0 0.2 0.1 -1.2
HDL Cholesterol 0.8 1.3 2.5 -0.0 -0.6 -1.3 -1.2 -1.6 -1.4
LDL Cholesterol 2.2 3.5 7.0 -2.5 -2.6 -1.8 -1.1 -1.5 0.9
Lupus 0.2 0.3 0.8 0.3 -0.3 -0.8 -0.9 -0.5 -0.3
Neuroticism (2016) 1.8 2.6 5.4 -0.6 -1.1 -1.7 -2.3 -2.2 0.6
Primary Biliary Cirrhosis 0.2 0.3 1.3 -0.6 0.1 -0.0 0.2 0.1 1.2
Rheumatoid Arthritis 1.7 2.4 10.4 1.5 1.0 0.4 0.4 0.2 -3.2
Schizophrenia (2014) 0.3 0.7 1.6 -0.7 -0.5 -0.4 -1.2 -0.7 1.2
Triglycerides 0.6 0.9 4.1 -1.0 -0.2 0.5 0.1 0.4 2.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 4.7 0.6 -0.0 -0.3 0.5 0.4 -2.2
Ulcerative Colitis 0.5 0.8 3.0 0.5 0.1 -0.4 -1.7 -0.9 0.6
Blood Eosinophil Count 0.6 4.4 7.5 1.5 1.4 -2.6 -2.6 -2.7 1.1
Blood Platelet Count 2.8 32.5 76.7 2.8 1.5 -4.8 -6.4 -8.8 -6.7
Blood Red Count 3.5 34.1 93.9 5.8 0.5 5.2 6.9 9.7 1.1
Blood White Count 0.3 2.6 5.1 0.6 -0.3 -2.3 -2.2 -2.2 -0.2
Heel T-Score 1.5 11.6 32.4 -0.2 0.7 3.8 3.8 5.7 2.7
BMI 0.4 2.4 4.6 0.8 -0.4 -2.1 -2.1 -2.0 -0.6
Height 0.2 3.9 7.8 -2.8 -2.2 -0.3 -2.0 -1.7 2.0
Waist Hip Ratio (WHR) 1.0 4.4 12.6 -2.1 -2.2 1.4 1.2 1.2 3.5
Systolic Blood Pressure 0.2 1.2 4.7 -0.3 0.1 -0.9 -0.9 -0.9 2.2
Smoking Status 0.4 1.1 2.2 -0.5 -1.5 -1.1 -1.1 -1.1 -0.6
Allergy or Eczema 0.7 1.9 2.9 1.4 1.6 0.6 1.7 1.2 -1.6
Cardiovascular Disease 2.3 7.4 18.5 -2.9 -1.5 -2.4 -2.5 -1.8 4.3
Hypothyroidism (self reported) 0.8 1.8 5.3 0.1 0.5 1.4 2.3 1.9 -0.3
Respiratory disease 0.8 1.9 5.3 -2.3 -1.1 0.5 1.2 0.2 1.6
Type 2 Diabetes (T2D) (2018) 0.9 1.7 4.4 -2.1 -1.8 0.2 0.1 0.3 1.5
Lung FEV1/FVC ratio 2.2 11.1 43.8 4.0 1.6 1.5 0.7 1.2 -6.6
Lung FVC 1.8 9.3 12.4 -3.5 -2.3 -2.2 -3.5 -3.4 3.1
Neuroticism 0.7 1.7 5.2 -1.1 -2.3 -1.2 -0.9 -1.0 -0.6
Chronotype (morning person) 0.2 0.5 1.1 0.6 0.4 -1.1 -0.9 -0.6 -0.7
Hair Pigment 0.0 1.4 5.3 0.5 0.3 1.1 1.3 -0.2 -2.3
Tanning 0.2 1.9 2.5 1.2 1.2 -1.4 -1.2 -1.6 -1.6
Hand grip strength (left) 1.2 3.2 9.2 -2.6 -1.3 0.0 -1.2 -0.4 3.0
Number of treatments/medications taken 0.4 0.6 2.2 0.5 1.1 0.1 0.3 0.2 1.5
Average weekly spirits intake 0.3 0.3 1.0 1.0 0.7 0.5 0.2 0.2 -0.4
Sensitivity / hurt feelings 0.1 0.2 0.6 0.2 -0.4 -0.4 0.1 -0.1 -0.8
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.4 -1.4 -1.6 -0.8 -0.6 -0.5 0.0
Hearing difficulty/problems: Yes 2.6 4.0 9.2 -2.4 -3.0 -1.8 -1.7 -1.6 0.8
Relative age of first facial hair 1.8 3.6 8.4 -0.6 -0.6 -2.5 -2.9 -2.5 0.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.8 0.9 0.9 0.1 0.7 0.9 -0.1
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.0 1.6 0.8 0.0 -0.8 -1.1 -1.7
Ever had hysterectomy (womb removed) 0.6 0.6 1.8 1.0 0.6 0.4 0.4 0.6 -1.4
Systolic blood pressure, automated reading 0.1 0.4 2.3 -0.1 -0.4 -0.0 0.1 -0.1 1.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.0 0.2 -0.1 0.2 0.2 -0.1
Angina 0.1 0.1 0.2 -0.1 0.1 -0.5 0.3 -0.0 0.4
Medication for hormone replacement therapy 1.2 1.4 3.2 0.1 -0.8 -1.4 -1.8 -1.4 -0.8
Vitamin and mineral supplements 0.3 0.4 1.1 -0.6 -0.6 0.3 0.4 0.7 1.1
Supplements: Zinc 0.5 0.6 1.3 -0.3 -0.5 -1.1 -0.8 -0.9 0.4
Medication: Co-codamol 0.4 0.5 1.4 0.6 -0.1 -1.2 -0.6 -0.7 -0.5
Medication: Metformin 0.3 0.5 1.8 -1.3 -0.3 0.0 -0.2 -0.5 0.8
Diabetes (father) 0.3 0.4 0.8 -0.5 -0.6 0.8 0.7 0.9 0.3
Diabetes (mother) 0.5 0.7 1.2 0.6 0.9 1.1 0.7 0.9 -0.6
Severe depression (siblings) 0.2 0.3 1.3 -0.0 -0.3 0.0 0.2 0.4 1.2
Pack years adult smoking proportion 2.3 3.4 4.7 -1.4 -1.6 -2.1 -2.2 -2.0 1.8
Impedance of leg (right) 0.7 3.4 13.0 -2.1 -0.7 0.7 0.8 1.1 3.6
Leg fat-free mass (left) 0.3 1.8 3.2 0.7 0.1 -1.0 -1.8 -1.8 -1.6
Trunk fat percentage 0.6 2.4 4.2 -1.1 -1.0 -1.9 -1.4 -1.6 2.0
Hand grip strength (right) 1.2 3.2 10.6 -2.1 -1.1 -0.2 -1.6 -0.6 3.3
Townsend deprivation index at recruitment 1.2 1.7 2.5 -0.5 -1.2 -1.5 -1.6 -1.3 1.5
Current tobacco smoking 0.1 0.1 0.3 -0.0 -0.4 0.2 0.1 0.2 -0.5
Average weekly fortified wine intake 0.6 0.7 1.6 0.1 0.1 0.2 1.3 1.1 -1.2
Maternal smoking around birth 0.6 0.9 1.8 0.6 0.6 -1.2 -1.4 -1.2 -0.2
Fed-up feelings 1.5 2.7 9.0 0.4 -1.1 -1.4 -1.2 -1.6 -3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.8 -0.9 -0.7 -0.7 -0.9 -0.6 0.3
Relative age voice broke 2.7 4.2 9.4 -0.6 -0.5 -2.5 -3.0 -3.1 0.1
Taking other prescription medications 0.8 1.2 3.5 1.3 1.9 -0.5 1.0 0.7 0.2
Age when periods started (menarche) 4.8 11.5 21.1 -2.0 -1.3 -4.2 -4.6 -4.5 2.0
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 8.3 2.9 1.6 -0.1 -0.2 -0.2 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 6.4 -0.8 -0.9 2.1 1.5 2.5 1.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.4 1.2 0.6 0.3 0.8 0.3 -1.6
Qualifications: CSEs or equivalent 0.4 0.5 1.2 -0.5 -0.2 1.1 0.5 0.1 -1.1
Serious illness, injury or assault to yourself 1.7 2.1 3.1 1.8 1.6 -1.4 -1.3 -1.2 -1.2
High blood pressure 2.8 7.9 18.2 -2.6 -1.6 -2.4 -2.9 -2.4 4.3
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.8 1.5 1.1 0.3 1.4 0.9 -1.7
Multivitamins +/- minerals 1.1 1.4 3.6 0.4 0.0 -1.2 -0.9 -1.6 -1.9
Stomach or abdominal pain in last month 4.6 5.7 12.0 3.5 2.9 1.3 2.3 2.0 -1.7
Supplements: Glucosamine 1.5 1.9 4.5 2.0 2.1 0.8 0.8 0.3 -1.2
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 5.8 2.1 2.4 0.0 0.2 0.3 -1.3
Medication: Atenolol 1.9 2.4 4.2 -0.9 -0.7 -1.4 -2.0 -1.8 1.9
Medication: Levothyroxine sodium 1.7 2.8 4.6 1.2 1.8 1.7 2.1 2.1 -0.7
Sitting height 0.4 2.5 4.8 0.5 0.3 2.2 1.6 1.9 -2.0
Chronic bronchitis/emphysema (father) 2.1 2.5 4.7 -2.2 -1.7 -1.8 -1.4 -1.3 0.8
High blood pressure (mother) 0.7 1.0 2.6 -0.6 0.1 -1.1 -1.3 -1.6 -0.2
Body mass index (BMI) 0.3 1.4 3.1 0.3 -0.4 -1.5 -1.8 -1.7 -0.4
Impedance of leg (left) 1.1 5.2 16.3 -3.1 -1.7 0.8 0.8 1.0 4.0
Leg predicted mass (left) 0.3 1.8 3.5 0.7 0.1 -1.0 -1.9 -1.9 -1.6
Trunk fat mass 0.6 2.4 3.1 -1.2 -1.1 -1.8 -1.8 -1.7 1.6
Waist circumference 0.1 0.4 0.6 -0.6 -0.8 -0.5 -0.6 -0.6 0.8
Number of incorrect matches in round 0.4 0.7 1.8 -1.1 -1.1 -0.1 -0.4 0.2 1.3
Past tobacco smoking 0.8 1.5 2.7 0.4 1.4 1.6 1.5 1.3 0.1
Alcohol usually taken with meals 1.2 1.9 3.0 1.3 1.7 1.5 1.6 1.4 -0.3
Nervous feelings 0.1 0.1 0.8 -0.0 -0.9 -0.1 -0.0 -0.1 0.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.2 -0.4 -1.1 0.0 0.1 0.3 -0.3
Hearing difficulty/problems with background noise 1.4 2.2 4.9 -1.8 -2.2 -1.0 -0.8 -1.1 1.4
Hair/balding pattern: Pattern 2 1.8 2.3 4.3 -1.7 -1.7 -0.6 -1.6 -0.9 2.1
Had menopause 0.4 0.5 0.9 0.6 0.3 -0.7 -1.0 -0.8 -0.8
Had other major operations 2.9 3.5 10.0 3.2 1.4 0.2 0.1 -0.0 -3.0
Forced vital capacity (FVC) 0.8 3.1 7.0 -2.7 -2.0 -0.1 -1.8 -1.8 1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 3.3 -1.5 -1.3 1.6 0.7 1.8 1.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.1 1.5 1.1 0.6 -0.6 0.3 -0.4
Qualifications: None of the above 0.8 1.6 3.5 0.6 0.4 -1.5 -1.9 -1.8 -0.5
Financial difficulties in last 2 years 0.2 0.3 0.7 0.3 -0.4 0.8 0.8 0.6 -0.0
Mouth/teeth dental problems 1.1 1.7 4.5 -0.5 -0.6 -1.2 -1.6 -2.1 1.1
Heart attack 0.4 0.5 2.1 0.7 1.4 0.2 0.4 0.2 0.5
Allergy 0.8 1.8 4.5 -1.3 -1.3 -0.4 -2.1 -1.3 1.1
Pain all over the body in last month 1.6 1.7 3.1 -0.2 -0.3 -1.8 -1.8 -1.6 -1.2
Diabetes (self-reported) 0.8 1.2 2.5 -1.6 -1.2 0.5 0.1 0.4 1.6
Hayfever/allergic rhinitis (self-reported) 2.6 3.5 9.4 2.2 2.3 0.0 1.0 0.4 -3.1
Medication: Ramipril 0.7 0.9 2.0 -0.2 0.7 -1.4 -0.5 -1.2 0.9
Medication: Simvastatin 2.9 4.3 11.3 -2.8 -2.1 -0.7 -1.0 -0.7 3.4
Fluid intelligence score 1.0 2.1 7.8 -1.5 0.3 0.6 0.5 1.3 2.8
Illnesses of siblings 2.5 3.6 12.4 2.3 1.5 -1.0 0.2 -0.4 -3.5
Neuroticism score 0.5 1.0 1.8 -0.5 -1.4 -1.2 -0.9 -1.0 -0.7
Weight 0.3 1.5 3.5 -0.7 -0.9 -1.2 -1.9 -1.7 -0.0
Impedance of arm (right) 0.3 1.3 4.8 -0.3 0.7 -0.3 1.2 0.8 2.2
Arm fat percentage (right) 0.2 1.0 2.4 0.1 -0.0 -1.5 -1.1 -1.4 0.6
Trunk fat-free mass 0.2 0.9 2.4 -0.2 -0.5 0.3 -1.3 -1.0 -1.6
Hip circumference 0.2 0.8 1.5 -0.1 -0.3 -1.0 -1.1 -1.2 -0.9
Time employed in main current job 0.2 0.2 0.8 -0.1 0.3 -0.7 -0.1 -0.2 0.9
Alcohol intake versus 10 years previously 0.6 0.8 1.6 0.2 0.3 -1.3 -1.0 -1.1 -1.0
Father’s age at death 2.3 3.0 8.8 2.8 0.9 -0.1 0.8 0.1 -3.0
Worrier / anxious feelings 0.4 0.7 2.3 -0.9 -1.5 -0.5 -0.7 -0.4 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.5 -0.1 -0.4 0.0 0.6 0.3 -1.2
Falls in the last year 0.7 0.9 2.5 1.6 1.2 0.6 0.3 0.5 -1.0
Hair/balding pattern: Pattern 3 2.2 3.4 7.5 1.1 1.1 1.3 2.7 2.0 -2.1
Number of live births 0.1 0.2 0.4 -0.5 0.6 0.2 0.1 0.2 0.6
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.1 -0.6 -0.9 0.6 -1.1 -0.9 -1.4
Pulse rate 7.6 12.8 31.4 -2.2 -1.7 -3.9 -5.6 -4.5 1.4
Happiness 1.1 1.3 2.2 0.9 0.4 1.0 1.5 1.5 -1.2
Noisy workplace 0.6 0.8 2.1 1.4 1.0 0.7 0.5 0.0 -1.0
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.8 -0.5 -0.2 1.7 2.0 2.2 1.0
Serious illness, injury or assault of a close relative in last 2 years 5.3 6.0 16.1 0.6 0.7 2.6 4.0 3.5 -0.8
Mouth/teeth dental problems: Dentures 0.8 1.3 6.9 0.1 -0.3 0.1 0.5 0.6 -2.6
Asthma 0.4 0.8 2.9 -1.1 -0.2 0.2 0.8 0.1 1.7
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 3.7 0.8 1.3 1.7 1.9 1.7 0.6
Medication: Cholesterol lowering 5.7 8.9 11.7 -2.8 -2.0 -3.2 -3.2 -3.0 3.4
Depression (self-reported) 0.7 0.9 1.8 -0.0 -0.6 -1.3 -1.3 -0.9 -0.8
Medication: Lansoprazole 1.0 1.2 2.9 0.3 1.3 1.1 1.0 1.7 0.6
Prospective memory result 0.1 0.2 0.5 -0.1 -0.6 -0.4 0.2 0.0 -0.7
Lung cancer (father) 1.1 1.3 2.3 1.0 0.6 -0.9 -1.1 -1.4 -1.5
Illnesses of mother 0.9 1.1 1.8 1.2 0.3 1.0 1.1 1.4 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.2 -0.9 -0.9 0.6 -1.0 -0.7 -1.5
Pulse wave Arterial Stiffness index 0.7 0.9 4.1 -0.8 -2.0 0.2 -0.3 0.3 0.5
Impedance of arm (left) 0.4 1.7 6.7 -0.7 0.8 -0.2 1.3 0.7 2.6
Arm fat mass (right) 0.3 1.3 2.9 -0.1 -0.4 -1.4 -1.7 -1.7 0.2
Trunk predicted mass 0.2 0.9 2.5 -0.1 -0.5 0.3 -1.2 -0.9 -1.6
Standing height 0.1 1.2 4.0 -2.0 -1.2 0.8 -0.3 -0.1 1.0
Length of working week for main job 0.3 0.4 0.9 0.4 0.0 -0.3 -1.0 -0.4 1.0
Exposure to tobacco smoke at home 0.7 0.8 1.6 -0.1 -1.2 -0.7 -1.0 -0.7 -1.1
Breastfed as a baby 0.7 0.8 2.4 0.1 -0.8 0.6 1.5 1.2 -0.3
Tense / ‘highly strung’ 0.6 1.0 2.9 -0.4 -1.7 -0.9 -1.2 -0.9 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.2 -0.3 0.1 -0.1 0.6 -0.7
Hair/balding pattern: Pattern 4 0.6 1.5 3.1 0.7 0.1 1.6 1.6 1.8 -0.6
Birth weight of first child 0.3 0.6 2.2 -0.1 -0.9 1.5 -0.4 0.5 -0.2
Peak expiratory flow (PEF) 0.4 1.0 3.8 1.1 0.6 0.7 0.4 0.4 -1.9
Pulse wave reflection index 2.0 2.4 4.9 -0.1 -1.0 2.2 1.9 2.2 0.7
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.2 0.0 0.3 -1.3 -1.5 -1.4 0.7
Loud music exposure frequency 0.2 0.2 0.6 0.8 0.5 0.0 -0.2 -0.4 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.6 0.4 0.0 0.0 -0.0 0.0 0.8
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 5.8 2.3 2.4 0.8 1.3 1.6 -0.3
Blood clot in the leg (DVT) 1.0 1.3 2.8 1.1 1.5 0.6 0.9 0.5 -1.7
Medication: Paracetamol 0.1 0.1 0.2 -0.1 -0.5 -0.3 -0.3 -0.4 0.0
Headache pain in last month 0.5 0.9 2.2 0.7 1.5 0.8 1.2 1.0 0.2
Medication for cholesterol, blood pressure or diabetes 6.3 10.4 15.0 2.7 2.0 3.4 3.4 3.6 -3.9
Glaucoma (self-reported) 0.7 0.8 1.4 1.2 0.6 1.2 0.9 1.0 0.1
Gout (self-reported) 0.4 0.5 1.1 0.8 0.6 -0.6 -0.6 -1.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 4.1 0.7 1.0 1.2 2.0 1.7 -0.4
Medication: Amlodipine 1.1 1.6 3.7 -0.8 -1.5 -0.6 -1.1 -1.0 1.9
Medication: Ventolin 100micrograms inhaler 1.5 2.0 4.6 -1.1 -0.5 -1.3 -1.2 -1.7 2.1
Birth weight 2.5 5.4 12.5 -0.6 -0.8 -2.8 -3.5 -3.2 0.4
Chronic bronchitis/emphysema (mother) 3.5 4.0 7.3 0.6 0.7 -2.1 -2.7 -2.6 2.2
High blood pressure (siblings) 0.7 1.0 4.2 -0.3 0.2 1.1 0.1 0.8 2.0
Forced vital capacity (FVC), Best measure 1.0 3.5 9.0 -3.0 -2.2 -0.4 -1.9 -1.8 0.8
Body fat percentage 0.7 2.6 3.8 -1.2 -1.1 -1.9 -1.6 -1.6 1.9
Leg fat percentage (right) 0.6 2.2 5.7 -1.3 -1.4 -1.0 -1.4 -1.1 2.4
Arm fat-free mass (right) 0.2 1.2 3.7 -0.4 -0.8 -0.3 -1.9 -1.4 -1.0
Exposure to tobacco smoke outside home 1.8 2.4 4.6 -0.5 -1.7 -1.5 -2.0 -2.1 -0.6
Comparative body size at age 10 0.2 0.6 1.2 -1.1 -0.9 0.1 0.1 1.1 0.5
Number of full brothers 0.8 1.0 3.2 -0.9 0.3 1.8 0.6 0.6 1.1
Worry too long after embarrassment 0.7 1.1 2.2 -1.4 -1.5 -0.8 -0.8 -0.8 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 3.6 -0.5 -0.8 -1.3 -1.9 -1.7 0.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.8 0.4 0.3 -0.9 -0.3 -0.5 0.0
Number of children fathered 1.5 1.7 3.0 1.7 1.7 0.7 1.2 0.6 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 8.8 -0.3 0.4 1.0 1.1 0.8 3.0
Age at first live birth 1.1 1.9 4.8 -0.1 0.2 1.7 1.9 2.2 0.1
Pulse wave peak to peak time 0.6 0.7 3.5 0.5 1.9 -0.1 0.2 -0.3 -0.5
Health satisfaction 0.5 0.6 1.5 1.1 1.2 -0.0 0.8 0.5 -0.4
Shortness of breath walking on level ground 1.1 1.4 2.9 -1.4 -0.8 -1.7 -1.1 -1.3 0.2
Qualifications: College or University degree 0.7 2.4 5.3 -0.8 0.1 1.1 1.9 2.3 1.8
Eye problems/disorders: None of the above 0.9 1.0 1.7 -0.4 -0.6 1.0 1.2 1.1 -1.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 3.0 0.4 1.0 0.4 0.5 0.7 1.7
Emphysema/chronic bronchitis 1.7 1.9 4.8 0.1 0.2 -1.6 -1.5 -2.2 1.2
Medication for pain relief, constipation, heartburn 0.9 1.5 2.4 -0.9 -1.6 -1.3 -1.3 -1.1 -1.1
Neck or shoulder pain in last month 1.5 2.1 11.8 0.5 -0.1 -0.7 0.5 -0.2 -3.4
Medication: Blood pressure 3.9 6.9 11.6 -1.7 -1.1 -2.7 -3.0 -3.1 3.4
Angina (self-reported) 0.1 0.1 0.2 0.1 0.4 -0.5 0.3 -0.0 0.4
Migraine (self-reported) 0.6 0.7 1.5 0.8 0.1 0.9 1.1 1.2 -0.5
Medication: Ibuprofen 2.0 2.4 4.5 1.1 1.6 1.9 2.1 1.7 0.3
Medication: Allopurinol 0.8 1.1 2.2 0.3 0.4 -1.2 -1.4 -1.5 1.0
Medication: Omeprazole 1.3 1.6 5.2 2.3 1.6 -0.7 -0.5 -0.4 -0.9
Medication: Seretide 50 evohaler 1.6 1.9 5.1 -0.4 -0.0 -1.9 -1.4 -2.3 0.4
Mean time to correctly identify matches 0.2 0.4 1.8 -0.4 -0.3 -0.6 -0.4 -0.3 1.3
Heart disease (mother) 1.4 1.7 7.2 -0.7 0.5 0.7 1.0 0.8 2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.6 0.8 0.8 0.0 0.1 -0.2 -1.3
Whole body fat mass 0.5 2.2 4.0 -0.8 -1.0 -1.8 -2.0 -1.9 1.1
Leg fat mass (right) 0.4 1.6 3.0 -0.8 -0.9 -1.1 -1.7 -1.4 1.4
Arm predicted mass (right) 0.2 1.2 3.2 -0.7 -1.1 -0.2 -1.8 -1.3 -0.8
Pulse rate, automated reading 9.8 31.6 63.5 -5.4 -4.8 -4.7 -8.0 -6.3 3.5
Alcohol intake frequency. 1.2 2.8 8.8 1.7 0.5 -1.5 -1.1 -1.2 -3.0
Comparative height size at age 10 0.1 0.3 0.9 -0.2 0.6 0.6 0.4 0.4 -1.0
Number of full sisters 1.8 2.2 4.0 -1.6 -1.7 -1.1 -1.2 -0.9 2.0
Suffer from ‘nerves’ 0.6 1.0 1.7 0.4 -1.3 -0.6 -0.9 -1.0 -1.3
Overall health rating 0.4 0.9 2.2 1.5 0.9 0.7 0.5 0.6 -1.1
Chest pain or discomfort 0.1 0.1 0.3 -0.3 -0.5 -0.4 0.4 0.3 -0.1
Had major operations 0.6 0.7 2.3 1.0 1.0 -0.1 -0.0 0.1 -1.5
Age at last live birth 1.0 1.5 3.6 -1.1 -0.3 1.1 1.1 1.2 1.9
Family relationship satisfaction 0.1 0.1 0.2 -0.1 -0.4 0.4 -0.2 0.4 0.4
Leg pain on walking 5.6 7.0 11.2 2.6 2.6 2.7 3.3 2.8 -1.3
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 4.8 1.5 1.4 0.3 0.2 -0.2 -2.2
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.4 0.6 1.3 0.2 1.1 1.0 -1.6
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 3.8 -1.3 -0.3 -1.7 -1.9 -1.8 1.9
Medication: Aspirin 1.0 1.3 1.9 0.9 1.4 1.0 0.9 1.1 1.4
Supplements: Vitamin C 1.5 1.7 3.1 -1.2 -0.9 1.6 1.8 1.6 0.3
Knee pain experienced in last month 1.2 1.9 7.4 1.5 0.9 0.5 0.7 0.3 -2.7
Hypertension (Self-reported) 3.2 8.9 19.9 -2.8 -1.6 -2.6 -3.1 -2.6 4.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 4.0 0.7 0.7 1.0 1.7 1.6 -2.0
Illnesses of father: Heart disease 0.8 1.0 5.2 -0.6 -0.4 0.4 -0.0 0.6 2.3
Illnesses of siblings: Diabetes 1.5 1.8 4.3 -0.1 0.0 2.1 1.5 2.0 -0.3
Smoking status: Previous 0.7 1.0 2.6 0.1 -0.7 -1.6 -1.2 -1.2 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.3 -2.1 -1.0 -0.5 -1.5 -1.5 -0.4
Whole body fat-free mass 0.2 1.2 2.7 0.0 -0.4 -0.3 -1.6 -1.4 -1.5
Leg fat-free mass (right) 0.3 1.7 3.2 0.5 -0.1 -0.9 -1.7 -1.8 -1.7
Arm fat percentage (left) 0.3 1.1 2.6 0.1 0.0 -1.6 -1.2 -1.5 0.8
Average weekly red wine intake 0.6 0.9 2.8 -0.8 -0.5 0.7 -0.0 1.1 1.7
Handedness (chirality/laterality): Left-handed 1.3 1.6 3.6 -1.9 -1.4 1.4 0.4 0.8 1.1
Mood swings 1.3 2.4 5.9 -1.5 -2.4 -1.3 -1.4 -1.3 -0.9
Loneliness, isolation 0.3 0.5 1.1 0.1 -0.4 0.4 0.7 1.0 -1.0
Long-standing illness, disability or infirmity 2.0 3.0 6.7 1.6 1.7 1.1 2.6 2.1 0.0
Ever had bowel cancer screening 0.6 0.7 1.6 0.4 0.8 -1.3 -0.7 -1.0 -0.0
Diabetes diagnosed by doctor 0.7 1.2 3.1 -1.8 -0.9 0.5 0.3 0.6 1.5
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 11.3 2.5 3.4 -0.3 -0.2 -0.4 0.2
Friendships satisfaction 1.8 2.2 4.5 0.3 0.1 1.9 2.1 2.1 -0.6
Qualifications: nursing, teaching 0.2 0.3 0.4 -0.6 0.2 -0.3 0.7 0.5 0.6
Commuting to job workplace: Walk 1.4 1.5 3.0 -0.2 0.2 -1.5 -1.6 -1.7 0.9
Eye problems/disorders: Cataract 4.0 4.6 6.4 -1.6 -0.7 -2.5 -2.4 -2.5 2.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 4.2 -0.5 -0.0 1.0 1.7 2.0 0.6
Medication for cholesterol 0.9 1.4 5.0 0.9 1.0 0.2 1.3 0.4 -2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 0.2 0.8 -0.3 -0.3 -0.5 -0.5
Back pain experienced in last month 1.3 1.9 3.7 1.9 1.6 1.2 0.9 1.1 -1.3
Mineral and other dietary supplements 1.4 1.9 4.5 -2.1 -1.7 -0.8 -1.1 -0.5 1.4
Breast cancer (self-reported) 3.0 3.5 10.7 2.1 2.3 -0.1 0.3 -1.0 -3.3
Asthma (self-reported) 0.4 0.8 3.0 -1.2 -0.4 -0.3 0.2 -0.3 1.7
Osteoporosis (self-reported) 0.6 0.7 1.7 0.4 0.6 -1.3 -0.4 -1.2 -0.6
Osteoarthritis (self-reported) 3.5 4.5 8.2 2.9 1.9 1.4 2.1 1.7 -2.4
Medication: Aspirin 1.5 1.9 4.0 1.8 2.0 1.1 0.8 1.1 1.0
Medication: Gliclazide 0.7 0.8 2.1 -0.2 0.1 1.4 1.2 1.1 -0.4
Illnesses of father: None of the above (group 1) 2.8 3.5 13.9 1.9 1.0 -0.7 -0.5 -1.3 -3.7
Smoking status: Current 0.2 0.2 0.7 -0.1 -0.4 0.5 0.4 0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.2 -1.8 -1.3 -0.1 -0.5 -0.7 -1.0
Whole body water mass 0.2 1.2 2.7 0.1 -0.3 -0.2 -1.6 -1.4 -1.6
Leg predicted mass (right) 0.3 1.7 3.4 0.4 -0.2 -0.9 -1.7 -1.9 -1.7
Arm fat mass (left) 0.3 1.2 2.6 -0.1 -0.2 -1.2 -1.6 -1.6 0.4
Number of self-reported non-cancer illnesses 0.3 0.5 1.2 0.6 1.1 -0.4 0.2 0.5 1.0
Average weekly champagne plus white wine intake 0.5 0.7 1.9 -0.7 -0.7 -1.0 -0.3 -0.3 -1.4
Miserableness 0.4 0.7 2.3 -1.2 -1.5 -0.1 -0.2 0.2 0.6
Guilty feelings 0.1 0.1 0.4 0.3 -0.5 0.3 -0.2 0.6 0.3
Wears glasses or contact lenses 0.2 0.3 0.8 -0.6 -0.4 -0.0 0.4 0.9 0.3
Ever taken oral contraceptive pill 0.6 0.7 2.0 -0.1 0.0 0.9 1.4 1.2 0.3
Hearing aid user 0.6 0.7 3.4 0.3 -0.3 -0.3 -0.5 -0.3 -1.8
Mother’s age at death 1.7 2.1 3.2 0.9 1.4 1.2 1.6 1.6 -1.8
Financial situation satisfaction 0.7 0.8 3.0 -0.4 -0.1 1.7 1.1 0.7 -0.4
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.7 -1.9 -0.8 -0.3 -0.1 0.0 1.5
Commuting to job workplace: Public transport 0.1 0.2 0.5 0.4 -0.3 -0.1 0.7 0.4 0.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.4 0.7 0.3 1.2 0.9 0.9 0.3
Medication: Blood pressure 1.2 2.4 9.1 -1.8 -1.1 0.5 -0.0 0.7 3.0
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.9 1.7 0.9 0.8 0.6 0.9 -1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.8 1.3 1.1 0.0 0.1 -0.7 -1.2
High cholesterol (Self-reported) 2.1 3.8 7.4 -2.7 -2.1 -1.2 -1.4 -0.4 2.7
Medication: Bendroflumethiazide 1.1 1.7 4.9 -1.7 -1.2 0.4 -0.5 -0.0 2.2
Medication: Paracetamol 0.1 0.1 0.5 0.1 -0.2 -0.1 -0.0 -0.3 -0.7
Medication: Lisinopril 2.3 3.0 3.9 -1.7 -1.5 -1.8 -2.0 -1.9 1.4
Medication: Atorvastatin 2.0 2.4 3.4 -1.2 -0.9 -1.7 -1.8 -1.6 1.9
Illnesses of father: High blood pressure 0.5 0.6 1.4 -0.4 -0.2 -1.2 -1.0 -0.2 0.9
Alcohol drinker status: Never 1.2 1.5 4.7 0.6 0.5 0.8 2.2 1.4 -0.9
Ever smoked 0.6 1.0 4.1 -0.8 -2.0 -0.7 -0.6 -0.6 -0.5
Basal metabolic rate 0.2 1.3 3.3 -0.2 -0.5 -0.6 -1.8 -1.6 -1.1
Leg fat percentage (left) 0.8 2.9 5.9 -1.9 -2.0 -1.0 -1.3 -1.1 2.4
Arm fat-free mass (left) 0.3 1.4 3.5 -0.5 -1.1 -0.4 -1.9 -1.4 -1.0
Number of operations (self-reported) 2.3 3.4 10.1 3.2 1.7 -0.3 -0.9 -0.4 -2.6
Average weekly beer plus cider intake 1.6 2.3 6.7 -2.0 -1.7 0.7 -0.3 0.3 2.6
Irritability 2.3 3.9 9.8 -0.5 -0.5 -3.1 -2.4 -2.4 1.2
Risk taking 0.5 0.8 2.7 0.5 0.7 1.6 0.8 0.8 -0.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.0 0.2 -0.4 0.4 0.3 0.8
Fractured/broken bones in last 5 years 0.3 0.4 1.1 1.1 0.2 0.5 0.2 0.2 -0.9
Age started oral contraceptive pill 0.9 1.1 4.0 -1.0 -0.8 -0.7 -0.6 -0.6 2.0
Diastolic blood pressure, automated reading 2.6 8.2 13.6 -2.0 -2.6 -2.3 -3.6 -2.6 3.7
Ever depressed for a whole week 0.1 0.2 0.4 0.6 0.3 -0.1 -0.5 -0.2 -0.5
Unable to work because of sickness or disability 1.6 2.0 3.3 1.2 0.7 -1.8 -1.4 -1.4 -1.8
Commuting to job workplace: Cycle 0.1 0.2 0.5 -0.7 -0.5 0.3 0.1 0.2 -0.4
Myopia 2.7 3.9 6.8 -1.5 -1.6 -2.6 -2.6 -2.1 0.9
Vascular/heart problems diagnosed by doctor 2.7 7.4 17.5 2.4 1.7 2.2 2.7 2.4 -4.2
Cholesterol lowering medication 1.8 2.6 9.4 -1.8 -1.4 0.2 -1.0 0.0 3.1
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 2.2 1.5 0.8 -0.5 -0.1 -0.0 -0.9
Pain experienced in last month 0.9 1.5 3.8 -1.5 -1.1 -0.8 -0.9 -0.7 1.9
Supplements: Calcium 0.2 0.2 1.1 0.0 -0.4 0.5 -0.1 -0.2 -1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.5 -0.3 -0.2 -0.4 -0.1 -0.4 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 0.7 1.4 0.0 0.2 0.1 0.5
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 3.9 1.6 2.0 0.9 1.3 0.9 -1.9
Heart disease (siblings) 3.3 4.1 9.7 -2.6 -1.6 -0.9 -1.5 -1.4 3.1
Alcohol drinker status: Previous 0.7 0.8 3.4 0.5 0.3 -0.4 -1.9 -0.8 -0.1
Pack years of smoking 3.2 4.7 7.5 -1.4 -1.5 -2.6 -2.7 -2.7 1.6
Impedance of whole body 0.5 2.6 11.0 -1.7 -0.3 -0.1 0.9 0.7 3.3
Leg fat mass (left) 0.5 2.0 3.2 -1.3 -1.3 -1.2 -1.8 -1.5 1.4
Arm predicted mass (left) 0.2 1.2 3.3 -0.3 -0.8 -0.3 -1.8 -1.3 -1.2