Hub : Genes

GPC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.244	0.116	8.3e-03	0.016	NA	0.077	NA	0.021	1.2e-01	NA	5.2e-03	NA	9.2e-02
2	GTEx	Brain Cerebellum	0.285	0.141	6.0e-03	0.306	NA	0.304	NA	0.294	1.0e-09	NA	1.2e-09	NA	2.3e-09
3	GTEx	Esophagus Mucosa	0.075	0.039	9.5e-03	0.027	NA	0.022	NA	-0.003	6.6e-03	NA	1.2e-02	NA	5.4e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.153	0.057	7.0e-06	0.106	NA	0.113	NA	0.091	2.0e-06	NA	9.1e-07	NA	1.1e-05
5	GTEx	Skin Sun Exposed Lower leg	0.073	0.031	1.8e-04	0.070	NA	0.038	NA	-0.002	2.0e-06	NA	4.0e-04	NA	5.8e-01
6	TCGA	Pancreatic Adenocarcinoma	0.134	0.078	6.0e-03	0.007	0.041	0.012	NA	0.013	1.6e-01	0.0077	1.0e-01	NA	8.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.9	3.1	6.1	0.1	0.6	-1.8	-2.5	-2.3	1.8
Bipolar Disorder or Schizophrenia	0.8	2.1	4.3	-0.4	0.4	-1.4	-2.1	-1.7	1.7
Depressed Affect (Nagel 2018)	1.2	2.5	7.2	-2.1	-2.7	-1.4	-0.8	-0.8	-0.5
Depression (Nagel 2018)	0.8	1.2	2.2	-0.6	-1.0	-1.5	-1.4	-1.1	0.8
Intelligence (Savage-Jansen 2018)	0.7	2.3	7.3	-2.2	-1.1	-0.3	0.3	0.1	2.7
Neuroticism (Nagel 2018)	1.7	3.9	10.8	-2.0	-3.3	-2.1	-1.5	-1.3	0.2
Schizophrenia (2018)	0.1	0.3	0.5	-0.6	-0.0	-0.4	-0.7	-0.3	0.7
Schizophrenia vs Biploar Disorder	1.3	1.7	3.2	-0.7	-0.7	0.9	1.6	1.7	-1.8
Worry (Nagel 2018)	0.3	0.6	1.7	0.4	-1.3	-0.3	-0.3	-0.3	-1.2
Alzheimer’s Disease (in mother)	12.0	14.0	18.4	3.5	3.8	4.2	4.3	3.9	-2.4
Alzheimer’s Disease (in father)	3.2	3.5	5.9	1.5	0.8	2.1	2.3	2.4	-1.6
Alzheimer’s Disease (including proxy)	16.9	24.5	37.2	4.1	4.0	5.7	6.1	5.5	-3.7
Crohns Disease (2017)	0.3	0.6	2.6	-0.6	0.8	-0.2	-0.4	-0.1	1.6
Irritable Bowel Disease (IBD)	0.8	2.0	3.9	-0.7	0.5	-1.3	-2.0	-1.6	1.8
Ulcerative Colitis (UC)	0.8	1.5	3.7	-0.0	0.7	-1.0	-1.9	-1.5	1.2
Major Depression (MDD)	0.8	1.0	2.6	1.2	0.7	-0.2	-1.6	-1.2	-0.2
Reaction Time	0.2	0.4	1.1	0.2	0.1	-0.7	-0.9	-0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	8.4	-1.7	-0.5	0.7	0.3	0.9	2.9
Breast Cancer	1.1	2.7	11.8	-1.6	-1.0	-0.3	0.0	0.9	3.4
Ovarian Cancer	0.4	0.5	1.6	-0.7	-1.3	0.4	0.3	0.6	0.5
Prostate Cancer	0.7	1.0	2.2	1.5	0.9	1.4	0.5	0.8	-0.2
Age at First Birth	0.2	0.3	1.1	-0.6	-1.1	0.4	-0.5	0.2	-0.3
Bipolar Disorder (2011)	1.7	1.6	3.4	-1.0	-1.3	-0.4	-1.8	-1.1	1.6
Body Mass Index (BMI) (2010)	0.7	0.9	1.9	-0.6	-1.0	-1.1	-1.4	-1.1	0.2
Coronary Artery Disease (CAD)	1.4	1.6	3.7	-0.7	-0.4	-1.9	-1.6	-1.0	1.4
Crohns Disease (2012)	1.3	2.2	3.8	0.7	1.8	1.6	1.3	2.0	1.1
Mean Putamen Volume	2.5	2.9	6.5	-1.9	-2.2	-1.1	-0.9	-0.7	2.5
Fasting Glucose	0.8	1.0	2.0	-1.4	-1.2	-1.1	-0.5	-0.9	0.2
HbA1C	1.7	1.8	4.5	2.1	2.0	-1.0	0.2	0.1	-1.2
HDL Cholesterol	0.8	1.3	2.5	-0.0	-0.6	-1.3	-1.2	-1.6	-1.4
LDL Cholesterol	2.2	3.5	7.0	-2.5	-2.6	-1.8	-1.1	-1.5	0.9
Lupus	0.2	0.3	0.8	0.3	-0.3	-0.8	-0.9	-0.5	-0.3
Neuroticism (2016)	1.8	2.6	5.4	-0.6	-1.1	-1.7	-2.3	-2.2	0.6
Primary Biliary Cirrhosis	0.2	0.3	1.3	-0.6	0.1	-0.0	0.2	0.1	1.2
Rheumatoid Arthritis	1.7	2.4	10.4	1.5	1.0	0.4	0.4	0.2	-3.2
Schizophrenia (2014)	0.3	0.7	1.6	-0.7	-0.5	-0.4	-1.2	-0.7	1.2
Triglycerides	0.6	0.9	4.1	-1.0	-0.2	0.5	0.1	0.4	2.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	4.7	0.6	-0.0	-0.3	0.5	0.4	-2.2
Ulcerative Colitis	0.5	0.8	3.0	0.5	0.1	-0.4	-1.7	-0.9	0.6
Blood Eosinophil Count	0.6	4.4	7.5	1.5	1.4	-2.6	-2.6	-2.7	1.1
Blood Platelet Count	2.8	32.5	76.7	2.8	1.5	-4.8	-6.4	-8.8	-6.7
Blood Red Count	3.5	34.1	93.9	5.8	0.5	5.2	6.9	9.7	1.1
Blood White Count	0.3	2.6	5.1	0.6	-0.3	-2.3	-2.2	-2.2	-0.2
Heel T-Score	1.5	11.6	32.4	-0.2	0.7	3.8	3.8	5.7	2.7
BMI	0.4	2.4	4.6	0.8	-0.4	-2.1	-2.1	-2.0	-0.6
Height	0.2	3.9	7.8	-2.8	-2.2	-0.3	-2.0	-1.7	2.0
Waist Hip Ratio (WHR)	1.0	4.4	12.6	-2.1	-2.2	1.4	1.2	1.2	3.5
Systolic Blood Pressure	0.2	1.2	4.7	-0.3	0.1	-0.9	-0.9	-0.9	2.2
Smoking Status	0.4	1.1	2.2	-0.5	-1.5	-1.1	-1.1	-1.1	-0.6
Allergy or Eczema	0.7	1.9	2.9	1.4	1.6	0.6	1.7	1.2	-1.6
Cardiovascular Disease	2.3	7.4	18.5	-2.9	-1.5	-2.4	-2.5	-1.8	4.3
Hypothyroidism (self reported)	0.8	1.8	5.3	0.1	0.5	1.4	2.3	1.9	-0.3
Respiratory disease	0.8	1.9	5.3	-2.3	-1.1	0.5	1.2	0.2	1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.4	-2.1	-1.8	0.2	0.1	0.3	1.5
Lung FEV1/FVC ratio	2.2	11.1	43.8	4.0	1.6	1.5	0.7	1.2	-6.6
Lung FVC	1.8	9.3	12.4	-3.5	-2.3	-2.2	-3.5	-3.4	3.1
Neuroticism	0.7	1.7	5.2	-1.1	-2.3	-1.2	-0.9	-1.0	-0.6
Chronotype (morning person)	0.2	0.5	1.1	0.6	0.4	-1.1	-0.9	-0.6	-0.7
Hair Pigment	0.0	1.4	5.3	0.5	0.3	1.1	1.3	-0.2	-2.3
Tanning	0.2	1.9	2.5	1.2	1.2	-1.4	-1.2	-1.6	-1.6
Hand grip strength (left)	1.2	3.2	9.2	-2.6	-1.3	0.0	-1.2	-0.4	3.0
Number of treatments/medications taken	0.4	0.6	2.2	0.5	1.1	0.1	0.3	0.2	1.5
Average weekly spirits intake	0.3	0.3	1.0	1.0	0.7	0.5	0.2	0.2	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.6	0.2	-0.4	-0.4	0.1	-0.1	-0.8
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.4	-1.4	-1.6	-0.8	-0.6	-0.5	0.0
Hearing difficulty/problems: Yes	2.6	4.0	9.2	-2.4	-3.0	-1.8	-1.7	-1.6	0.8
Relative age of first facial hair	1.8	3.6	8.4	-0.6	-0.6	-2.5	-2.9	-2.5	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.9	0.9	0.1	0.7	0.9	-0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.0	1.6	0.8	0.0	-0.8	-1.1	-1.7
Ever had hysterectomy (womb removed)	0.6	0.6	1.8	1.0	0.6	0.4	0.4	0.6	-1.4
Systolic blood pressure, automated reading	0.1	0.4	2.3	-0.1	-0.4	-0.0	0.1	-0.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.0	0.2	-0.1	0.2	0.2	-0.1
Angina	0.1	0.1	0.2	-0.1	0.1	-0.5	0.3	-0.0	0.4
Medication for hormone replacement therapy	1.2	1.4	3.2	0.1	-0.8	-1.4	-1.8	-1.4	-0.8
Vitamin and mineral supplements	0.3	0.4	1.1	-0.6	-0.6	0.3	0.4	0.7	1.1
Supplements: Zinc	0.5	0.6	1.3	-0.3	-0.5	-1.1	-0.8	-0.9	0.4
Medication: Co-codamol	0.4	0.5	1.4	0.6	-0.1	-1.2	-0.6	-0.7	-0.5
Medication: Metformin	0.3	0.5	1.8	-1.3	-0.3	0.0	-0.2	-0.5	0.8
Diabetes (father)	0.3	0.4	0.8	-0.5	-0.6	0.8	0.7	0.9	0.3
Diabetes (mother)	0.5	0.7	1.2	0.6	0.9	1.1	0.7	0.9	-0.6
Severe depression (siblings)	0.2	0.3	1.3	-0.0	-0.3	0.0	0.2	0.4	1.2
Pack years adult smoking proportion	2.3	3.4	4.7	-1.4	-1.6	-2.1	-2.2	-2.0	1.8
Impedance of leg (right)	0.7	3.4	13.0	-2.1	-0.7	0.7	0.8	1.1	3.6
Leg fat-free mass (left)	0.3	1.8	3.2	0.7	0.1	-1.0	-1.8	-1.8	-1.6
Trunk fat percentage	0.6	2.4	4.2	-1.1	-1.0	-1.9	-1.4	-1.6	2.0
Hand grip strength (right)	1.2	3.2	10.6	-2.1	-1.1	-0.2	-1.6	-0.6	3.3
Townsend deprivation index at recruitment	1.2	1.7	2.5	-0.5	-1.2	-1.5	-1.6	-1.3	1.5
Current tobacco smoking	0.1	0.1	0.3	-0.0	-0.4	0.2	0.1	0.2	-0.5
Average weekly fortified wine intake	0.6	0.7	1.6	0.1	0.1	0.2	1.3	1.1	-1.2
Maternal smoking around birth	0.6	0.9	1.8	0.6	0.6	-1.2	-1.4	-1.2	-0.2
Fed-up feelings	1.5	2.7	9.0	0.4	-1.1	-1.4	-1.2	-1.6	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	-0.9	-0.7	-0.7	-0.9	-0.6	0.3
Relative age voice broke	2.7	4.2	9.4	-0.6	-0.5	-2.5	-3.0	-3.1	0.1
Taking other prescription medications	0.8	1.2	3.5	1.3	1.9	-0.5	1.0	0.7	0.2
Age when periods started (menarche)	4.8	11.5	21.1	-2.0	-1.3	-4.2	-4.6	-4.5	2.0
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	8.3	2.9	1.6	-0.1	-0.2	-0.2	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.4	-0.8	-0.9	2.1	1.5	2.5	1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.4	1.2	0.6	0.3	0.8	0.3	-1.6
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-0.5	-0.2	1.1	0.5	0.1	-1.1
Serious illness, injury or assault to yourself	1.7	2.1	3.1	1.8	1.6	-1.4	-1.3	-1.2	-1.2
High blood pressure	2.8	7.9	18.2	-2.6	-1.6	-2.4	-2.9	-2.4	4.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.8	1.5	1.1	0.3	1.4	0.9	-1.7
Multivitamins +/- minerals	1.1	1.4	3.6	0.4	0.0	-1.2	-0.9	-1.6	-1.9
Stomach or abdominal pain in last month	4.6	5.7	12.0	3.5	2.9	1.3	2.3	2.0	-1.7
Supplements: Glucosamine	1.5	1.9	4.5	2.0	2.1	0.8	0.8	0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	5.8	2.1	2.4	0.0	0.2	0.3	-1.3
Medication: Atenolol	1.9	2.4	4.2	-0.9	-0.7	-1.4	-2.0	-1.8	1.9
Medication: Levothyroxine sodium	1.7	2.8	4.6	1.2	1.8	1.7	2.1	2.1	-0.7
Sitting height	0.4	2.5	4.8	0.5	0.3	2.2	1.6	1.9	-2.0
Chronic bronchitis/emphysema (father)	2.1	2.5	4.7	-2.2	-1.7	-1.8	-1.4	-1.3	0.8
High blood pressure (mother)	0.7	1.0	2.6	-0.6	0.1	-1.1	-1.3	-1.6	-0.2
Body mass index (BMI)	0.3	1.4	3.1	0.3	-0.4	-1.5	-1.8	-1.7	-0.4
Impedance of leg (left)	1.1	5.2	16.3	-3.1	-1.7	0.8	0.8	1.0	4.0
Leg predicted mass (left)	0.3	1.8	3.5	0.7	0.1	-1.0	-1.9	-1.9	-1.6
Trunk fat mass	0.6	2.4	3.1	-1.2	-1.1	-1.8	-1.8	-1.7	1.6
Waist circumference	0.1	0.4	0.6	-0.6	-0.8	-0.5	-0.6	-0.6	0.8
Number of incorrect matches in round	0.4	0.7	1.8	-1.1	-1.1	-0.1	-0.4	0.2	1.3
Past tobacco smoking	0.8	1.5	2.7	0.4	1.4	1.6	1.5	1.3	0.1
Alcohol usually taken with meals	1.2	1.9	3.0	1.3	1.7	1.5	1.6	1.4	-0.3
Nervous feelings	0.1	0.1	0.8	-0.0	-0.9	-0.1	-0.0	-0.1	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	-0.4	-1.1	0.0	0.1	0.3	-0.3
Hearing difficulty/problems with background noise	1.4	2.2	4.9	-1.8	-2.2	-1.0	-0.8	-1.1	1.4
Hair/balding pattern: Pattern 2	1.8	2.3	4.3	-1.7	-1.7	-0.6	-1.6	-0.9	2.1
Had menopause	0.4	0.5	0.9	0.6	0.3	-0.7	-1.0	-0.8	-0.8
Had other major operations	2.9	3.5	10.0	3.2	1.4	0.2	0.1	-0.0	-3.0
Forced vital capacity (FVC)	0.8	3.1	7.0	-2.7	-2.0	-0.1	-1.8	-1.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.3	-1.5	-1.3	1.6	0.7	1.8	1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.1	1.5	1.1	0.6	-0.6	0.3	-0.4
Qualifications: None of the above	0.8	1.6	3.5	0.6	0.4	-1.5	-1.9	-1.8	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.7	0.3	-0.4	0.8	0.8	0.6	-0.0
Mouth/teeth dental problems	1.1	1.7	4.5	-0.5	-0.6	-1.2	-1.6	-2.1	1.1
Heart attack	0.4	0.5	2.1	0.7	1.4	0.2	0.4	0.2	0.5
Allergy	0.8	1.8	4.5	-1.3	-1.3	-0.4	-2.1	-1.3	1.1
Pain all over the body in last month	1.6	1.7	3.1	-0.2	-0.3	-1.8	-1.8	-1.6	-1.2
Diabetes (self-reported)	0.8	1.2	2.5	-1.6	-1.2	0.5	0.1	0.4	1.6
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	9.4	2.2	2.3	0.0	1.0	0.4	-3.1
Medication: Ramipril	0.7	0.9	2.0	-0.2	0.7	-1.4	-0.5	-1.2	0.9
Medication: Simvastatin	2.9	4.3	11.3	-2.8	-2.1	-0.7	-1.0	-0.7	3.4
Fluid intelligence score	1.0	2.1	7.8	-1.5	0.3	0.6	0.5	1.3	2.8
Illnesses of siblings	2.5	3.6	12.4	2.3	1.5	-1.0	0.2	-0.4	-3.5
Neuroticism score	0.5	1.0	1.8	-0.5	-1.4	-1.2	-0.9	-1.0	-0.7
Weight	0.3	1.5	3.5	-0.7	-0.9	-1.2	-1.9	-1.7	-0.0
Impedance of arm (right)	0.3	1.3	4.8	-0.3	0.7	-0.3	1.2	0.8	2.2
Arm fat percentage (right)	0.2	1.0	2.4	0.1	-0.0	-1.5	-1.1	-1.4	0.6
Trunk fat-free mass	0.2	0.9	2.4	-0.2	-0.5	0.3	-1.3	-1.0	-1.6
Hip circumference	0.2	0.8	1.5	-0.1	-0.3	-1.0	-1.1	-1.2	-0.9
Time employed in main current job	0.2	0.2	0.8	-0.1	0.3	-0.7	-0.1	-0.2	0.9
Alcohol intake versus 10 years previously	0.6	0.8	1.6	0.2	0.3	-1.3	-1.0	-1.1	-1.0
Father’s age at death	2.3	3.0	8.8	2.8	0.9	-0.1	0.8	0.1	-3.0
Worrier / anxious feelings	0.4	0.7	2.3	-0.9	-1.5	-0.5	-0.7	-0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.5	-0.1	-0.4	0.0	0.6	0.3	-1.2
Falls in the last year	0.7	0.9	2.5	1.6	1.2	0.6	0.3	0.5	-1.0
Hair/balding pattern: Pattern 3	2.2	3.4	7.5	1.1	1.1	1.3	2.7	2.0	-2.1
Number of live births	0.1	0.2	0.4	-0.5	0.6	0.2	0.1	0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.1	-0.6	-0.9	0.6	-1.1	-0.9	-1.4
Pulse rate	7.6	12.8	31.4	-2.2	-1.7	-3.9	-5.6	-4.5	1.4
Happiness	1.1	1.3	2.2	0.9	0.4	1.0	1.5	1.5	-1.2
Noisy workplace	0.6	0.8	2.1	1.4	1.0	0.7	0.5	0.0	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.8	-0.5	-0.2	1.7	2.0	2.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	5.3	6.0	16.1	0.6	0.7	2.6	4.0	3.5	-0.8
Mouth/teeth dental problems: Dentures	0.8	1.3	6.9	0.1	-0.3	0.1	0.5	0.6	-2.6
Asthma	0.4	0.8	2.9	-1.1	-0.2	0.2	0.8	0.1	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.7	0.8	1.3	1.7	1.9	1.7	0.6
Medication: Cholesterol lowering	5.7	8.9	11.7	-2.8	-2.0	-3.2	-3.2	-3.0	3.4
Depression (self-reported)	0.7	0.9	1.8	-0.0	-0.6	-1.3	-1.3	-0.9	-0.8
Medication: Lansoprazole	1.0	1.2	2.9	0.3	1.3	1.1	1.0	1.7	0.6
Prospective memory result	0.1	0.2	0.5	-0.1	-0.6	-0.4	0.2	0.0	-0.7
Lung cancer (father)	1.1	1.3	2.3	1.0	0.6	-0.9	-1.1	-1.4	-1.5
Illnesses of mother	0.9	1.1	1.8	1.2	0.3	1.0	1.1	1.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.9	-0.9	0.6	-1.0	-0.7	-1.5
Pulse wave Arterial Stiffness index	0.7	0.9	4.1	-0.8	-2.0	0.2	-0.3	0.3	0.5
Impedance of arm (left)	0.4	1.7	6.7	-0.7	0.8	-0.2	1.3	0.7	2.6
Arm fat mass (right)	0.3	1.3	2.9	-0.1	-0.4	-1.4	-1.7	-1.7	0.2
Trunk predicted mass	0.2	0.9	2.5	-0.1	-0.5	0.3	-1.2	-0.9	-1.6
Standing height	0.1	1.2	4.0	-2.0	-1.2	0.8	-0.3	-0.1	1.0
Length of working week for main job	0.3	0.4	0.9	0.4	0.0	-0.3	-1.0	-0.4	1.0
Exposure to tobacco smoke at home	0.7	0.8	1.6	-0.1	-1.2	-0.7	-1.0	-0.7	-1.1
Breastfed as a baby	0.7	0.8	2.4	0.1	-0.8	0.6	1.5	1.2	-0.3
Tense / ‘highly strung’	0.6	1.0	2.9	-0.4	-1.7	-0.9	-1.2	-0.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.2	-0.3	0.1	-0.1	0.6	-0.7
Hair/balding pattern: Pattern 4	0.6	1.5	3.1	0.7	0.1	1.6	1.6	1.8	-0.6
Birth weight of first child	0.3	0.6	2.2	-0.1	-0.9	1.5	-0.4	0.5	-0.2
Peak expiratory flow (PEF)	0.4	1.0	3.8	1.1	0.6	0.7	0.4	0.4	-1.9
Pulse wave reflection index	2.0	2.4	4.9	-0.1	-1.0	2.2	1.9	2.2	0.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	0.0	0.3	-1.3	-1.5	-1.4	0.7
Loud music exposure frequency	0.2	0.2	0.6	0.8	0.5	0.0	-0.2	-0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.6	0.4	0.0	0.0	-0.0	0.0	0.8
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	5.8	2.3	2.4	0.8	1.3	1.6	-0.3
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.1	1.5	0.6	0.9	0.5	-1.7
Medication: Paracetamol	0.1	0.1	0.2	-0.1	-0.5	-0.3	-0.3	-0.4	0.0
Headache pain in last month	0.5	0.9	2.2	0.7	1.5	0.8	1.2	1.0	0.2
Medication for cholesterol, blood pressure or diabetes	6.3	10.4	15.0	2.7	2.0	3.4	3.4	3.6	-3.9
Glaucoma (self-reported)	0.7	0.8	1.4	1.2	0.6	1.2	0.9	1.0	0.1
Gout (self-reported)	0.4	0.5	1.1	0.8	0.6	-0.6	-0.6	-1.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.1	0.7	1.0	1.2	2.0	1.7	-0.4
Medication: Amlodipine	1.1	1.6	3.7	-0.8	-1.5	-0.6	-1.1	-1.0	1.9
Medication: Ventolin 100micrograms inhaler	1.5	2.0	4.6	-1.1	-0.5	-1.3	-1.2	-1.7	2.1
Birth weight	2.5	5.4	12.5	-0.6	-0.8	-2.8	-3.5	-3.2	0.4
Chronic bronchitis/emphysema (mother)	3.5	4.0	7.3	0.6	0.7	-2.1	-2.7	-2.6	2.2
High blood pressure (siblings)	0.7	1.0	4.2	-0.3	0.2	1.1	0.1	0.8	2.0
Forced vital capacity (FVC), Best measure	1.0	3.5	9.0	-3.0	-2.2	-0.4	-1.9	-1.8	0.8
Body fat percentage	0.7	2.6	3.8	-1.2	-1.1	-1.9	-1.6	-1.6	1.9
Leg fat percentage (right)	0.6	2.2	5.7	-1.3	-1.4	-1.0	-1.4	-1.1	2.4
Arm fat-free mass (right)	0.2	1.2	3.7	-0.4	-0.8	-0.3	-1.9	-1.4	-1.0
Exposure to tobacco smoke outside home	1.8	2.4	4.6	-0.5	-1.7	-1.5	-2.0	-2.1	-0.6
Comparative body size at age 10	0.2	0.6	1.2	-1.1	-0.9	0.1	0.1	1.1	0.5
Number of full brothers	0.8	1.0	3.2	-0.9	0.3	1.8	0.6	0.6	1.1
Worry too long after embarrassment	0.7	1.1	2.2	-1.4	-1.5	-0.8	-0.8	-0.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.6	-0.5	-0.8	-1.3	-1.9	-1.7	0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	0.4	0.3	-0.9	-0.3	-0.5	0.0
Number of children fathered	1.5	1.7	3.0	1.7	1.7	0.7	1.2	0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	8.8	-0.3	0.4	1.0	1.1	0.8	3.0
Age at first live birth	1.1	1.9	4.8	-0.1	0.2	1.7	1.9	2.2	0.1
Pulse wave peak to peak time	0.6	0.7	3.5	0.5	1.9	-0.1	0.2	-0.3	-0.5
Health satisfaction	0.5	0.6	1.5	1.1	1.2	-0.0	0.8	0.5	-0.4
Shortness of breath walking on level ground	1.1	1.4	2.9	-1.4	-0.8	-1.7	-1.1	-1.3	0.2
Qualifications: College or University degree	0.7	2.4	5.3	-0.8	0.1	1.1	1.9	2.3	1.8
Eye problems/disorders: None of the above	0.9	1.0	1.7	-0.4	-0.6	1.0	1.2	1.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.0	0.4	1.0	0.4	0.5	0.7	1.7
Emphysema/chronic bronchitis	1.7	1.9	4.8	0.1	0.2	-1.6	-1.5	-2.2	1.2
Medication for pain relief, constipation, heartburn	0.9	1.5	2.4	-0.9	-1.6	-1.3	-1.3	-1.1	-1.1
Neck or shoulder pain in last month	1.5	2.1	11.8	0.5	-0.1	-0.7	0.5	-0.2	-3.4
Medication: Blood pressure	3.9	6.9	11.6	-1.7	-1.1	-2.7	-3.0	-3.1	3.4
Angina (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.5	0.3	-0.0	0.4
Migraine (self-reported)	0.6	0.7	1.5	0.8	0.1	0.9	1.1	1.2	-0.5
Medication: Ibuprofen	2.0	2.4	4.5	1.1	1.6	1.9	2.1	1.7	0.3
Medication: Allopurinol	0.8	1.1	2.2	0.3	0.4	-1.2	-1.4	-1.5	1.0
Medication: Omeprazole	1.3	1.6	5.2	2.3	1.6	-0.7	-0.5	-0.4	-0.9
Medication: Seretide 50 evohaler	1.6	1.9	5.1	-0.4	-0.0	-1.9	-1.4	-2.3	0.4
Mean time to correctly identify matches	0.2	0.4	1.8	-0.4	-0.3	-0.6	-0.4	-0.3	1.3
Heart disease (mother)	1.4	1.7	7.2	-0.7	0.5	0.7	1.0	0.8	2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	0.8	0.8	0.0	0.1	-0.2	-1.3
Whole body fat mass	0.5	2.2	4.0	-0.8	-1.0	-1.8	-2.0	-1.9	1.1
Leg fat mass (right)	0.4	1.6	3.0	-0.8	-0.9	-1.1	-1.7	-1.4	1.4
Arm predicted mass (right)	0.2	1.2	3.2	-0.7	-1.1	-0.2	-1.8	-1.3	-0.8
Pulse rate, automated reading	9.8	31.6	63.5	-5.4	-4.8	-4.7	-8.0	-6.3	3.5
Alcohol intake frequency.	1.2	2.8	8.8	1.7	0.5	-1.5	-1.1	-1.2	-3.0
Comparative height size at age 10	0.1	0.3	0.9	-0.2	0.6	0.6	0.4	0.4	-1.0
Number of full sisters	1.8	2.2	4.0	-1.6	-1.7	-1.1	-1.2	-0.9	2.0
Suffer from ‘nerves’	0.6	1.0	1.7	0.4	-1.3	-0.6	-0.9	-1.0	-1.3
Overall health rating	0.4	0.9	2.2	1.5	0.9	0.7	0.5	0.6	-1.1
Chest pain or discomfort	0.1	0.1	0.3	-0.3	-0.5	-0.4	0.4	0.3	-0.1
Had major operations	0.6	0.7	2.3	1.0	1.0	-0.1	-0.0	0.1	-1.5
Age at last live birth	1.0	1.5	3.6	-1.1	-0.3	1.1	1.1	1.2	1.9
Family relationship satisfaction	0.1	0.1	0.2	-0.1	-0.4	0.4	-0.2	0.4	0.4
Leg pain on walking	5.6	7.0	11.2	2.6	2.6	2.7	3.3	2.8	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.8	1.5	1.4	0.3	0.2	-0.2	-2.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.4	0.6	1.3	0.2	1.1	1.0	-1.6
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	3.8	-1.3	-0.3	-1.7	-1.9	-1.8	1.9
Medication: Aspirin	1.0	1.3	1.9	0.9	1.4	1.0	0.9	1.1	1.4
Supplements: Vitamin C	1.5	1.7	3.1	-1.2	-0.9	1.6	1.8	1.6	0.3
Knee pain experienced in last month	1.2	1.9	7.4	1.5	0.9	0.5	0.7	0.3	-2.7
Hypertension (Self-reported)	3.2	8.9	19.9	-2.8	-1.6	-2.6	-3.1	-2.6	4.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.0	0.7	0.7	1.0	1.7	1.6	-2.0
Illnesses of father: Heart disease	0.8	1.0	5.2	-0.6	-0.4	0.4	-0.0	0.6	2.3
Illnesses of siblings: Diabetes	1.5	1.8	4.3	-0.1	0.0	2.1	1.5	2.0	-0.3
Smoking status: Previous	0.7	1.0	2.6	0.1	-0.7	-1.6	-1.2	-1.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.3	-2.1	-1.0	-0.5	-1.5	-1.5	-0.4
Whole body fat-free mass	0.2	1.2	2.7	0.0	-0.4	-0.3	-1.6	-1.4	-1.5
Leg fat-free mass (right)	0.3	1.7	3.2	0.5	-0.1	-0.9	-1.7	-1.8	-1.7
Arm fat percentage (left)	0.3	1.1	2.6	0.1	0.0	-1.6	-1.2	-1.5	0.8
Average weekly red wine intake	0.6	0.9	2.8	-0.8	-0.5	0.7	-0.0	1.1	1.7
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.6	-1.9	-1.4	1.4	0.4	0.8	1.1
Mood swings	1.3	2.4	5.9	-1.5	-2.4	-1.3	-1.4	-1.3	-0.9
Loneliness, isolation	0.3	0.5	1.1	0.1	-0.4	0.4	0.7	1.0	-1.0
Long-standing illness, disability or infirmity	2.0	3.0	6.7	1.6	1.7	1.1	2.6	2.1	0.0
Ever had bowel cancer screening	0.6	0.7	1.6	0.4	0.8	-1.3	-0.7	-1.0	-0.0
Diabetes diagnosed by doctor	0.7	1.2	3.1	-1.8	-0.9	0.5	0.3	0.6	1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	11.3	2.5	3.4	-0.3	-0.2	-0.4	0.2
Friendships satisfaction	1.8	2.2	4.5	0.3	0.1	1.9	2.1	2.1	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.4	-0.6	0.2	-0.3	0.7	0.5	0.6
Commuting to job workplace: Walk	1.4	1.5	3.0	-0.2	0.2	-1.5	-1.6	-1.7	0.9
Eye problems/disorders: Cataract	4.0	4.6	6.4	-1.6	-0.7	-2.5	-2.4	-2.5	2.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.2	-0.5	-0.0	1.0	1.7	2.0	0.6
Medication for cholesterol	0.9	1.4	5.0	0.9	1.0	0.2	1.3	0.4	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.2	0.8	-0.3	-0.3	-0.5	-0.5
Back pain experienced in last month	1.3	1.9	3.7	1.9	1.6	1.2	0.9	1.1	-1.3
Mineral and other dietary supplements	1.4	1.9	4.5	-2.1	-1.7	-0.8	-1.1	-0.5	1.4
Breast cancer (self-reported)	3.0	3.5	10.7	2.1	2.3	-0.1	0.3	-1.0	-3.3
Asthma (self-reported)	0.4	0.8	3.0	-1.2	-0.4	-0.3	0.2	-0.3	1.7
Osteoporosis (self-reported)	0.6	0.7	1.7	0.4	0.6	-1.3	-0.4	-1.2	-0.6
Osteoarthritis (self-reported)	3.5	4.5	8.2	2.9	1.9	1.4	2.1	1.7	-2.4
Medication: Aspirin	1.5	1.9	4.0	1.8	2.0	1.1	0.8	1.1	1.0
Medication: Gliclazide	0.7	0.8	2.1	-0.2	0.1	1.4	1.2	1.1	-0.4
Illnesses of father: None of the above (group 1)	2.8	3.5	13.9	1.9	1.0	-0.7	-0.5	-1.3	-3.7
Smoking status: Current	0.2	0.2	0.7	-0.1	-0.4	0.5	0.4	0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.2	-1.8	-1.3	-0.1	-0.5	-0.7	-1.0
Whole body water mass	0.2	1.2	2.7	0.1	-0.3	-0.2	-1.6	-1.4	-1.6
Leg predicted mass (right)	0.3	1.7	3.4	0.4	-0.2	-0.9	-1.7	-1.9	-1.7
Arm fat mass (left)	0.3	1.2	2.6	-0.1	-0.2	-1.2	-1.6	-1.6	0.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	0.6	1.1	-0.4	0.2	0.5	1.0
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-0.7	-0.7	-1.0	-0.3	-0.3	-1.4
Miserableness	0.4	0.7	2.3	-1.2	-1.5	-0.1	-0.2	0.2	0.6
Guilty feelings	0.1	0.1	0.4	0.3	-0.5	0.3	-0.2	0.6	0.3
Wears glasses or contact lenses	0.2	0.3	0.8	-0.6	-0.4	-0.0	0.4	0.9	0.3
Ever taken oral contraceptive pill	0.6	0.7	2.0	-0.1	0.0	0.9	1.4	1.2	0.3
Hearing aid user	0.6	0.7	3.4	0.3	-0.3	-0.3	-0.5	-0.3	-1.8
Mother’s age at death	1.7	2.1	3.2	0.9	1.4	1.2	1.6	1.6	-1.8
Financial situation satisfaction	0.7	0.8	3.0	-0.4	-0.1	1.7	1.1	0.7	-0.4
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.7	-1.9	-0.8	-0.3	-0.1	0.0	1.5
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.4	-0.3	-0.1	0.7	0.4	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.4	0.7	0.3	1.2	0.9	0.9	0.3
Medication: Blood pressure	1.2	2.4	9.1	-1.8	-1.1	0.5	-0.0	0.7	3.0
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.9	1.7	0.9	0.8	0.6	0.9	-1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	1.3	1.1	0.0	0.1	-0.7	-1.2
High cholesterol (Self-reported)	2.1	3.8	7.4	-2.7	-2.1	-1.2	-1.4	-0.4	2.7
Medication: Bendroflumethiazide	1.1	1.7	4.9	-1.7	-1.2	0.4	-0.5	-0.0	2.2
Medication: Paracetamol	0.1	0.1	0.5	0.1	-0.2	-0.1	-0.0	-0.3	-0.7
Medication: Lisinopril	2.3	3.0	3.9	-1.7	-1.5	-1.8	-2.0	-1.9	1.4
Medication: Atorvastatin	2.0	2.4	3.4	-1.2	-0.9	-1.7	-1.8	-1.6	1.9
Illnesses of father: High blood pressure	0.5	0.6	1.4	-0.4	-0.2	-1.2	-1.0	-0.2	0.9
Alcohol drinker status: Never	1.2	1.5	4.7	0.6	0.5	0.8	2.2	1.4	-0.9
Ever smoked	0.6	1.0	4.1	-0.8	-2.0	-0.7	-0.6	-0.6	-0.5
Basal metabolic rate	0.2	1.3	3.3	-0.2	-0.5	-0.6	-1.8	-1.6	-1.1
Leg fat percentage (left)	0.8	2.9	5.9	-1.9	-2.0	-1.0	-1.3	-1.1	2.4
Arm fat-free mass (left)	0.3	1.4	3.5	-0.5	-1.1	-0.4	-1.9	-1.4	-1.0
Number of operations (self-reported)	2.3	3.4	10.1	3.2	1.7	-0.3	-0.9	-0.4	-2.6
Average weekly beer plus cider intake	1.6	2.3	6.7	-2.0	-1.7	0.7	-0.3	0.3	2.6
Irritability	2.3	3.9	9.8	-0.5	-0.5	-3.1	-2.4	-2.4	1.2
Risk taking	0.5	0.8	2.7	0.5	0.7	1.6	0.8	0.8	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.0	0.2	-0.4	0.4	0.3	0.8
Fractured/broken bones in last 5 years	0.3	0.4	1.1	1.1	0.2	0.5	0.2	0.2	-0.9
Age started oral contraceptive pill	0.9	1.1	4.0	-1.0	-0.8	-0.7	-0.6	-0.6	2.0
Diastolic blood pressure, automated reading	2.6	8.2	13.6	-2.0	-2.6	-2.3	-3.6	-2.6	3.7
Ever depressed for a whole week	0.1	0.2	0.4	0.6	0.3	-0.1	-0.5	-0.2	-0.5
Unable to work because of sickness or disability	1.6	2.0	3.3	1.2	0.7	-1.8	-1.4	-1.4	-1.8
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.7	-0.5	0.3	0.1	0.2	-0.4
Myopia	2.7	3.9	6.8	-1.5	-1.6	-2.6	-2.6	-2.1	0.9
Vascular/heart problems diagnosed by doctor	2.7	7.4	17.5	2.4	1.7	2.2	2.7	2.4	-4.2
Cholesterol lowering medication	1.8	2.6	9.4	-1.8	-1.4	0.2	-1.0	0.0	3.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.2	1.5	0.8	-0.5	-0.1	-0.0	-0.9
Pain experienced in last month	0.9	1.5	3.8	-1.5	-1.1	-0.8	-0.9	-0.7	1.9
Supplements: Calcium	0.2	0.2	1.1	0.0	-0.4	0.5	-0.1	-0.2	-1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	-0.3	-0.2	-0.4	-0.1	-0.4	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	0.7	1.4	0.0	0.2	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.9	1.6	2.0	0.9	1.3	0.9	-1.9
Heart disease (siblings)	3.3	4.1	9.7	-2.6	-1.6	-0.9	-1.5	-1.4	3.1
Alcohol drinker status: Previous	0.7	0.8	3.4	0.5	0.3	-0.4	-1.9	-0.8	-0.1
Pack years of smoking	3.2	4.7	7.5	-1.4	-1.5	-2.6	-2.7	-2.7	1.6
Impedance of whole body	0.5	2.6	11.0	-1.7	-0.3	-0.1	0.9	0.7	3.3
Leg fat mass (left)	0.5	2.0	3.2	-1.3	-1.3	-1.2	-1.8	-1.5	1.4
Arm predicted mass (left)	0.2	1.2	3.3	-0.3	-0.8	-0.3	-1.8	-1.3	-1.2