TWAS hub - GATS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2020	0.0580	2.2e-09	0.031	0.056	0.069	0.067	0.087	9.3e-05	2.3e-07	8.0e-09	1.3e-08	9.8e-11
2	GTEx	Brain Nucleus accumbens basal ganglia	0.1310	0.0720	9.7e-03	0.049	NA	0.034	NA	0.056	1.9e-02	NA	4.3e-02	NA	1.3e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.3209	0.0694	5.4e-07	0.077	0.046	0.065	0.063	0.069	3.7e-10	1.4e-06	9.0e-09	1.4e-08	2.9e-09
4	YFS	Blood	0.3945	0.0471	0.0e+00	0.353	0.403	0.406	0.383	0.403	1.6e-121	1.3e-143	3.8e-145	9.4e-135	8.3e-144
5	TCGA	Breast Invasive Carcinoma	0.0259	0.0175	5.4e-04	0.011	0.006	0.006	NA	0.004	2.1e-03	1.7e-02	1.6e-02	NA	3.5e-02
6	TCGA	Lung Adenocarcinoma	0.0340	0.0273	2.6e-03	0.024	0.018	0.017	NA	0.021	7.7e-04	3.2e-03	3.4e-03	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Alzheimer’s Disease (including proxy)	18.8	27.2	38.1	-4.5	-4.9	-3.4	-6.2	-6.0	-5.8
Alzheimer’s Disease (in mother)	14.9	17.5	23.8	-4.1	-3.8	-3.3	-4.1	-4.7	-4.9
Pulse rate, automated reading	9.2	29.8	52.1	6.5	7.2	2.9	6.0	4.6	4.5
Leg pain on walking	6.8	8.5	10.6	-3.2	-3.0	-2.3	-2.6	-3.0	-3.2
Pulse rate	6.4	10.8	17.3	3.4	4.2	0.8	3.5	3.7	3.0
Serious illness, injury or assault of a close relative in last 2 years	6.4	7.4	12.0	-2.6	-3.5	-0.2	-2.8	-3.3	-2.6
Medication for cholesterol, blood pressure or diabetes	6.0	10.0	18.7	-2.6	-4.2	-0.9	-4.3	-2.9	-2.6
Stomach or abdominal pain in last month	5.2	6.5	10.8	-3.3	-2.8	-2.8	-2.5	-1.3	-2.2
Medication: Cholesterol lowering	4.9	7.6	14.6	2.4	3.8	1.0	3.6	2.5	2.4
Age when periods started (menarche)	4.7	11.4	22.0	3.3	4.7	0.6	3.8	3.6	2.9
Hearing difficulty/problems: Yes	4.3	6.5	11.8	3.4	1.9	3.0	1.9	1.9	2.7
Pack years of smoking	4.1	6.0	9.9	2.1	2.7	0.8	3.1	2.9	2.5
Eye problems/disorders: Cataract	3.8	4.5	11.1	1.0	2.6	0.1	3.3	2.2	1.7
Osteoarthritis (self-reported)	3.8	4.9	8.2	-2.3	-2.9	-1.6	-2.4	-1.9	-2.1
Hayfever/allergic rhinitis (self-reported)	3.6	4.7	14.5	-2.2	-2.2	-1.5	-3.8	-0.8	-1.1
Heart disease (siblings)	3.6	4.4	10.8	2.0	3.2	0.3	3.3	0.7	0.6
Medication: Blood pressure	3.5	6.2	15.3	1.6	3.2	0.3	3.9	2.3	1.9
Blood Red Count	3.4	33.0	86.1	-3.9	-9.3	-2.0	-1.1	-7.3	-6.2
Mean Putamen Volume	3.3	3.8	10.6	2.3	1.7	1.7	3.3	0.5	1.0
Pack years adult smoking proportion	3.2	5.0	9.8	2.0	2.3	1.0	3.1	2.3	2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	11.6	-2.5	-0.3	-3.4	0.2	0.1	-1.3
Medication: Lisinopril	3.1	4.0	6.1	2.4	2.0	0.8	2.5	2.0	1.8
Chronic bronchitis/emphysema (father)	3.0	3.5	5.4	2.1	1.4	2.1	1.2	1.9	2.3
Hypertension (Self-reported)	3.0	8.2	18.3	2.3	4.3	0.4	4.2	2.2	1.8
Alzheimer’s Disease (in father)	2.9	3.1	6.3	-0.8	-1.6	-0.5	-2.5	-2.3	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	9.3	-2.0	-1.2	-1.6	-3.0	-1.4	-1.6
Diastolic blood pressure, automated reading	2.6	8.2	18.2	3.4	4.3	1.1	3.2	2.0	2.0
High blood pressure	2.5	7.0	15.1	2.2	3.8	0.4	3.9	2.1	1.8
Relative age voice broke	2.4	3.6	5.5	2.1	1.8	0.7	1.9	2.4	2.1
Hair/balding pattern: Pattern 3	2.4	3.5	6.7	-1.6	-2.6	-0.8	-2.3	-1.7	-1.6
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.1	-2.1	-1.5	-2.2	-0.9	-1.4	-2.0
Chronic bronchitis/emphysema (mother)	2.4	2.8	7.9	0.0	2.2	-1.1	2.8	1.5	0.7
Myopia	2.4	3.5	4.6	2.2	2.1	1.4	1.5	2.0	2.0
LDL Cholesterol	2.3	3.7	6.0	2.4	1.7	2.1	1.0	1.7	2.1
Number of full sisters	2.3	2.8	4.8	1.9	2.2	1.0	2.1	1.2	1.3
Medication: Levothyroxine sodium	2.2	3.7	4.7	-2.1	-2.0	-1.3	-1.6	-2.2	-2.2
Illnesses of siblings	2.2	3.1	8.8	-1.1	-2.8	-0.5	-3.0	0.7	0.4
Birth weight	2.2	4.7	7.2	2.2	2.4	0.3	2.7	2.5	2.0
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.8	1.1	2.6	-0.1	2.3	1.4	1.0
Long-standing illness, disability or infirmity	2.2	3.4	7.0	-2.6	-2.0	-1.5	-1.0	-1.6	-1.9
Vascular/heart problems diagnosed by doctor	2.2	6.0	13.8	-2.1	-3.4	-0.7	-3.7	-1.8	-1.7
Medication: Ibuprofen	2.1	2.5	4.5	-2.1	-1.1	-1.6	-0.4	-1.6	-2.0
Medication: Aspirin	2.1	2.8	5.7	-2.0	-0.2	-1.9	0.2	-1.8	-2.4
Neuroticism (Nagel 2018)	2.0	4.8	9.7	2.7	0.1	3.1	1.1	1.8	2.7
Cardiovascular Disease	2.0	6.5	17.2	2.4	3.5	0.3	4.2	1.5	1.3
Hand grip strength (left)	2.0	5.3	14.2	1.8	3.7	0.6	3.8	0.1	0.2
Hand grip strength (right)	2.0	5.4	15.1	1.6	3.7	0.2	3.9	0.5	0.4
Exposure to tobacco smoke outside home	2.0	2.7	5.1	2.0	1.0	1.5	0.2	2.0	2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	5.0	-1.1	0.9	-1.6	2.2	-1.3	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	7.8	-1.1	-1.7	0.3	-2.8	-1.2	-0.7
Mood swings	2.0	3.7	7.5	2.2	-0.1	2.7	0.5	1.8	2.5
Breast cancer (self-reported)	2.0	2.3	8.1	-1.6	-1.1	-1.4	-2.8	0.5	-0.0
Mother’s age at death	2.0	2.5	5.2	-1.5	-2.3	-0.7	-2.0	-1.3	-1.2
Townsend deprivation index at recruitment	1.9	2.7	4.4	1.9	2.1	0.9	2.0	1.3	1.3
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.5	-1.8	-0.9	-2.1	-1.9	-0.5	-1.1
Medication: Simvastatin	1.9	2.8	7.0	1.7	2.6	1.1	2.3	0.3	0.6
Number of children fathered	1.9	2.1	4.1	-1.9	-1.6	-1.3	-2.0	-0.5	-0.8
Neck or shoulder pain in last month	1.9	2.7	7.4	-0.3	-2.7	0.9	-2.7	0.2	0.7
Commuting to job workplace: Car/motor vehicle	1.9	2.1	5.0	-1.5	-1.5	-1.2	-2.2	-0.8	-1.1
Back pain experienced in last month	1.9	2.8	4.0	-2.0	-2.0	-1.0	-2.0	-1.3	-1.4
Mineral and other dietary supplements	1.9	2.5	5.3	2.0	1.5	1.0	2.3	1.0	1.1
Allergy or Eczema	1.8	4.6	9.0	-2.5	-3.0	-1.0	-2.5	-1.7	-1.6
Relative age of first facial hair	1.8	3.6	5.2	2.2	2.2	0.2	1.8	2.3	1.9
Supplements: Glucosamine	1.8	2.3	4.7	-2.2	-1.4	-1.6	-1.1	-1.0	-1.5
Medication: Atenolol	1.8	2.2	6.2	1.2	2.5	0.2	1.8	1.2	1.0
Hearing difficulty/problems with background noise	1.8	2.8	4.6	1.9	1.5	1.4	2.2	1.3	1.6
Hair/balding pattern: Pattern 2	1.8	2.3	5.6	1.4	1.6	1.2	2.4	0.9	1.1
Bipolar Disorder (2018)	1.7	2.7	5.3	0.2	2.3	-1.2	2.1	1.9	1.1
Crohns Disease (2012)	1.7	2.8	5.4	-2.0	-0.4	-1.8	0.4	-1.9	-2.3
Lung FVC	1.7	8.9	21.7	2.6	4.7	1.4	2.7	2.8	2.7
Had other major operations	1.7	2.1	6.4	-0.7	-2.3	-0.6	-2.5	0.1	0.0
Blood clot in the leg (DVT)	1.7	2.2	7.0	-1.4	-0.8	-1.1	-2.6	-0.9	-1.1
Emphysema/chronic bronchitis	1.7	1.9	4.7	0.3	1.6	-0.7	2.2	1.6	0.9
Blood Platelet Count	1.6	18.5	50.4	2.6	1.4	0.7	-3.8	7.1	6.1
Medication: Lansoprazole	1.6	1.8	3.7	-1.2	-0.2	-0.8	-1.2	-1.9	-1.9
Exposure to tobacco smoke at home	1.6	1.8	3.1	1.3	0.0	1.7	-1.3	1.3	1.8
Friendships satisfaction	1.6	1.9	3.7	-1.2	-1.7	0.2	-1.1	-1.9	-1.5
High cholesterol (Self-reported)	1.6	2.8	5.7	2.0	1.9	1.5	2.4	0.5	1.0
Alcohol drinker status: Never	1.6	1.9	4.5	-1.2	-2.1	0.2	-1.9	-1.1	-0.8
Rheumatoid Arthritis	1.5	2.0	8.3	-0.9	-1.7	-0.2	-2.9	-0.3	-0.3
Medication for hormone replacement therapy	1.5	1.6	3.4	1.4	0.4	0.9	0.5	1.8	1.8
Alcohol usually taken with meals	1.5	2.5	4.0	-1.7	-1.5	-2.0	-0.8	-1.3	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.5	-1.9	-0.8	-1.4	-0.0	-1.5	-1.8
Medication: Amlodipine	1.5	2.1	3.3	1.6	1.8	1.2	1.6	1.0	1.3
Illnesses of father: None of the above (group 1)	1.5	1.9	5.4	-0.7	-2.3	-0.2	-1.8	1.1	0.8
HbA1C	1.4	1.5	3.9	-2.0	-1.4	-1.4	-1.1	0.2	-0.3
Mouth/teeth dental problems	1.4	2.1	5.5	1.5	2.4	0.4	1.5	1.1	1.1
Health satisfaction	1.4	1.8	3.1	-1.8	-1.1	-1.4	-1.1	-1.1	-1.4
Heart disease (mother)	1.4	1.7	3.8	-1.0	1.0	-1.1	1.9	-1.0	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	6.0	-1.1	-1.6	-0.8	-2.4	0.1	-0.1
Irritability	1.4	2.3	5.5	0.6	1.7	-0.2	1.4	2.4	1.7
Cholesterol lowering medication	1.4	2.1	5.4	1.1	2.3	0.8	2.3	-0.2	0.1
Coronary Artery Disease (CAD)	1.3	1.6	2.8	1.4	1.4	0.2	1.7	1.2	1.2
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.6	0.6	-1.9	0.8	-1.8	0.6	0.8
Supplements: Zinc	1.3	1.4	3.8	1.0	0.7	0.5	2.0	1.2	1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	5.1	-0.8	-1.4	-1.3	-2.3	0.1	-0.3
Past tobacco smoking	1.3	2.4	4.0	-1.9	-0.9	-1.0	-1.2	-2.0	-2.0
Allergy	1.3	2.9	6.4	1.9	2.5	0.4	2.1	1.3	1.2
Happiness	1.3	1.6	3.1	-1.3	-1.8	-0.2	-1.3	-1.4	-1.2
Pulse wave Arterial Stiffness index	1.3	1.5	4.4	2.1	0.5	1.7	0.9	0.2	0.8
Illnesses of siblings: Diabetes	1.3	1.6	2.9	-1.0	-1.6	0.3	-1.3	-1.7	-1.2
Medication: Atorvastatin	1.3	1.7	3.4	0.6	1.9	0.2	1.8	1.3	1.2
Depressed Affect (Nagel 2018)	1.2	2.6	7.2	1.7	-0.2	2.7	0.3	1.2	2.0
Neuroticism (2016)	1.2	1.7	3.3	1.8	1.3	1.3	1.1	1.6	0.0
Fed-up feelings	1.2	2.3	3.6	0.8	-1.4	1.8	-1.4	1.5	1.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.6	-1.0	-1.9	-0.2	-1.5	-0.6	-0.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	6.9	-1.4	-2.6	-0.3	-2.2	-1.0	-0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.9	0.2	1.4	-0.2	2.2	1.3	0.9
High blood pressure (siblings)	1.2	1.7	3.5	-0.1	1.9	-1.0	1.8	-1.1	-1.2
Alcohol intake frequency.	1.2	2.9	7.4	0.4	-1.6	1.1	-2.7	1.6	1.8
Medication: Aspirin	1.2	1.6	3.8	-1.3	0.3	-1.2	0.4	-1.7	-2.0
Ever smoked	1.2	2.1	3.9	1.7	0.1	1.8	0.2	1.6	2.0
Pain experienced in last month	1.2	2.0	6.2	1.2	2.5	0.3	1.6	1.0	0.8
Body Mass Index (BMI) (2010)	1.1	1.5	2.6	1.5	0.7	0.7	1.6	1.4	1.2
Tense / ‘highly strung’	1.1	1.7	2.8	1.7	0.6	1.6	0.7	1.3	1.6
Forced vital capacity (FVC), Best measure	1.1	3.8	6.6	2.3	2.6	1.9	1.4	1.5	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	1.0	0.8	0.2	1.9	1.5	1.1
Pulse wave peak to peak time	1.1	1.3	3.8	-1.9	-0.4	-1.6	-0.9	-0.2	-0.8
Medication: Seretide 50 evohaler	1.1	1.3	3.9	0.1	1.0	-0.0	0.9	2.0	1.4
Suffer from ‘nerves’	1.1	1.7	3.1	1.3	-0.6	1.8	-1.0	1.1	1.6
Number of operations (self-reported)	1.1	1.6	4.0	-1.2	-2.0	-1.2	-1.6	0.5	0.0
Bipolar Disorder or Schizophrenia	1.0	2.4	6.2	0.7	2.5	-1.1	2.1	1.3	0.7
Lung FEV1/FVC ratio	1.0	4.9	20.7	1.0	-2.0	0.3	-4.5	-1.5	-1.0
Taking other prescription medications	1.0	1.5	4.7	-2.2	-0.7	-1.7	-0.6	-0.2	-0.8
Father’s age at death	1.0	1.3	4.2	-0.2	-1.9	0.2	-2.1	0.1	0.3
Knee pain experienced in last month	1.0	1.5	4.2	-0.9	-2.1	-0.2	-1.9	-0.3	-0.3
Medication for cholesterol	1.0	1.5	3.5	-1.4	-1.7	-0.6	-1.9	-0.3	-0.5
Hearing aid user	1.0	1.1	3.8	0.5	-1.1	1.0	-2.0	0.2	0.6
Medication: Bendroflumethiazide	1.0	1.4	4.1	1.1	1.6	0.9	2.0	-0.2	0.0
Leg fat percentage (left)	1.0	3.5	7.3	2.4	2.7	1.3	2.2	0.6	1.0
Schizophrenia vs Biploar Disorder	0.9	1.2	3.0	0.0	-1.7	1.0	-1.4	-1.1	-0.4
Irritable Bowel Disease (IBD)	0.9	2.1	5.8	0.5	2.4	-0.6	2.3	0.8	0.3
Breast Cancer	0.9	2.2	8.8	1.0	1.8	0.4	3.0	-0.2	-0.2
HDL Cholesterol	0.9	1.5	3.3	0.9	-0.3	1.5	-0.1	1.5	1.8
Heel T-Score	0.9	7.3	17.3	-2.4	-1.3	-1.1	1.7	-4.2	-3.9
Neuroticism	0.9	2.2	6.2	1.4	-0.7	2.5	0.2	1.1	1.9
Forced vital capacity (FVC)	0.9	3.5	7.8	2.1	2.8	1.5	1.7	1.2	1.5
Fluid intelligence score	0.9	1.9	5.4	-0.7	0.9	-0.5	2.3	-1.5	-1.5
Mouth/teeth dental problems: Dentures	0.9	1.5	5.1	-0.3	-1.9	0.4	-2.3	0.0	0.2
Pulse wave reflection index	0.9	1.2	4.0	0.1	-0.9	0.8	0.2	-2.0	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.3	-1.5	-1.3	-0.6	-1.3	-1.5	-1.3
Age at first live birth	0.9	1.6	4.4	-0.8	-1.4	0.3	-0.5	-2.1	-1.6
Smoking status: Previous	0.9	1.3	2.2	1.4	0.6	0.4	1.2	1.5	1.3
Medication: Gliclazide	0.9	1.0	1.9	-0.8	-1.2	0.2	-0.9	-1.4	-1.0
Financial situation satisfaction	0.9	1.2	3.1	-0.7	-0.3	0.1	-1.8	-1.4	-1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.5	-0.9	-2.1	-0.6	-1.0	-0.3	-0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.0	-1.2	-0.6	-0.6	-2.2	-0.1	-0.3
Fasting Glucose	0.8	0.9	1.6	1.0	0.8	1.1	0.1	1.0	1.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.9	-0.7	1.0	-1.4	0.5	-0.7	-1.2
Medication for pain relief, constipation, heartburn	0.8	1.4	3.1	1.8	0.3	1.3	-0.3	1.1	1.5
Had major operations	0.8	0.9	3.0	-1.1	-1.7	-0.5	-1.0	-0.0	-0.2
Supplements: Vitamin C	0.8	0.9	2.2	-0.4	-1.2	1.5	-0.1	-1.2	-0.4
Commuting to job workplace: Walk	0.8	0.9	2.0	0.4	1.0	-0.3	1.4	1.2	0.8
Depression (Nagel 2018)	0.7	1.0	2.3	0.9	1.2	0.5	1.5	0.9	0.7
Ulcerative Colitis (UC)	0.7	1.2	3.5	0.2	1.9	-0.7	1.8	0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.9	-0.0	1.5	0.0	2.4	-0.8	-0.9
Prostate Cancer	0.7	1.0	2.9	-1.2	-1.7	-0.3	-0.7	-0.8	-0.8
Smoking Status	0.7	1.8	3.4	1.9	0.4	1.3	0.5	1.5	1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	2.2	-1.5	-1.2	-0.9	-0.3	-0.3	-0.7
Ever had hysterectomy (womb removed)	0.7	0.7	2.9	-0.2	-1.2	-0.2	-1.7	-0.3	-0.2
Multivitamins +/- minerals	0.7	0.9	2.1	0.2	-0.8	0.6	-0.7	1.4	1.4
Number of incorrect matches in round	0.7	1.2	2.1	1.3	1.2	1.3	1.4	-0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.7	-1.0	-0.5	-1.3	-0.7	-0.7	-1.0
Heart attack	0.7	0.9	2.5	-1.5	-0.1	-1.6	0.2	-0.3	-0.9
Pain all over the body in last month	0.7	0.7	1.7	0.9	0.2	0.3	0.4	1.3	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.6	-1.1	-0.7	-0.1	-0.3	-2.1	-1.8
Depression (self-reported)	0.7	0.8	1.7	1.3	-0.2	0.9	0.5	1.0	1.1
Headache pain in last month	0.7	1.3	2.5	-1.6	-0.8	-1.3	-0.6	-0.9	-1.3
Leg fat percentage (right)	0.7	2.6	7.0	1.9	2.6	0.6	2.1	0.6	0.7
Worry too long after embarrassment	0.7	1.1	2.3	1.2	0.7	1.2	1.5	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	2.6	1.3	1.1	1.1	0.4	1.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	4.1	2.0	1.4	1.3	-0.2	0.3	0.8
Average weekly champagne plus white wine intake	0.7	0.9	1.2	0.9	-1.0	0.6	0.9	1.1	1.1
Medication: Blood pressure	0.7	1.4	3.8	0.8	1.8	0.6	1.9	-0.6	-0.3
Illnesses of father: High blood pressure	0.7	0.8	1.5	1.1	1.2	-0.1	1.2	0.7	0.5
Average weekly beer plus cider intake	0.7	1.1	2.6	0.6	1.5	1.2	1.6	-0.1	0.3
Unable to work because of sickness or disability	0.7	0.9	2.6	0.5	-0.2	-0.1	-0.8	1.6	1.3
Leg fat mass (left)	0.7	2.7	6.5	2.0	2.5	0.7	1.8	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	7.5	0.7	1.7	0.6	2.7	-0.2	-0.1
Worry (Nagel 2018)	0.6	1.3	2.6	0.9	-1.5	1.6	-0.7	0.5	1.2
Hypothyroidism (self reported)	0.6	1.5	3.0	-1.2	-1.4	-0.2	-0.8	-1.7	-1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.6	1.1	0.6	1.6	1.3	0.6	1.0
Average weekly spirits intake	0.6	0.8	1.5	-0.7	-0.8	-1.2	-1.0	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	1.1	0.4	1.3	1.0	0.5	0.8
Diabetes (mother)	0.6	0.7	1.4	-0.8	-1.1	-0.8	-1.2	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.8	-0.3	-0.7	0.3	0.6	-2.2	-1.7
Serious illness, injury or assault to yourself	0.6	0.8	2.2	-0.8	-0.4	-1.5	-0.8	0.9	0.1
Trunk fat mass	0.6	2.7	6.6	1.8	2.6	0.4	2.0	1.1	1.0
Had menopause	0.6	0.7	1.4	0.7	1.1	-0.3	-1.2	0.9	0.6
Qualifications: None of the above	0.6	1.2	3.2	1.0	0.9	-0.1	0.4	1.8	1.5
Hair/balding pattern: Pattern 4	0.6	1.4	4.3	-0.3	-1.1	0.5	-0.5	-2.1	-1.4
Birth weight of first child	0.6	1.0	2.5	1.6	1.2	0.7	1.0	-0.8	-0.4
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.4	0.6	1.1	-0.3	0.9	1.2	0.8
Body fat percentage	0.6	2.5	6.0	1.8	2.4	0.4	2.0	0.9	0.9
Shortness of breath walking on level ground	0.6	0.7	1.4	0.5	0.2	0.7	0.8	1.2	1.1
Qualifications: College or University degree	0.6	1.9	3.8	-1.5	-0.4	-1.0	0.9	-1.8	-2.0
Eye problems/disorders: None of the above	0.6	0.8	1.5	0.4	-0.9	0.7	-1.2	-1.1	-0.5
Medication: Allopurinol	0.6	0.8	2.9	0.5	1.7	-0.6	0.5	0.9	0.4
Whole body fat mass	0.6	2.5	5.9	1.8	2.4	0.3	1.7	1.2	1.1
Illnesses of father: Heart disease	0.6	0.8	2.2	0.6	1.5	-0.3	1.2	-0.5	-0.5
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.7	0.8	0.9	0.6	1.3	-0.8	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	0.8	1.3	0.8	1.1	0.1	0.4
Age started oral contraceptive pill	0.6	0.7	1.9	0.5	1.4	0.2	1.0	0.8	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	-1.4	0.0	-1.5	0.3	-0.2	-0.8
Schizophrenia (2014)	0.5	1.0	2.4	1.1	1.5	0.1	1.5	0.4	0.4
Triglycerides	0.5	0.8	2.8	0.3	1.1	-0.6	1.7	-0.2	-0.5
Trunk fat percentage	0.5	2.2	5.5	1.5	2.3	0.2	2.0	0.8	0.8
Worrier / anxious feelings	0.5	0.9	2.2	1.2	-0.5	1.5	0.9	0.4	0.8
Illnesses of mother	0.5	0.6	1.7	-0.8	-1.3	-0.0	-0.8	-0.5	-0.4
Length of working week for main job	0.5	0.6	1.9	0.2	1.4	-0.3	1.0	0.7	0.4
Number of full brothers	0.5	0.6	1.2	-0.9	0.1	-0.8	0.6	-0.9	-1.1
Leg fat mass (right)	0.5	2.1	6.1	1.7	2.5	0.2	1.6	0.7	0.7
Overall health rating	0.5	1.1	1.9	-1.4	-1.2	-0.8	-1.0	-0.8	-0.9
Age at last live birth	0.5	0.7	2.5	-0.2	0.0	0.4	0.3	-1.6	-1.2
Average weekly red wine intake	0.5	0.8	1.3	0.5	1.1	-0.0	1.1	-1.0	-0.9
Loneliness, isolation	0.5	0.7	1.8	-0.4	-1.3	0.9	-1.1	-0.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	-0.6	-1.4	0.2	-0.1	-1.2	-0.9
Risk taking	0.5	0.8	1.3	-1.1	-0.6	-0.9	0.8	-0.7	-1.0
Crohns Disease (2017)	0.4	0.9	1.9	-0.5	1.4	-1.0	1.3	-0.2	-0.7
Reaction Time	0.4	0.7	3.2	0.1	0.5	-0.6	1.8	0.4	-0.0
Ulcerative Colitis	0.4	0.6	2.5	0.5	0.8	0.1	1.6	0.0	0.0
Waist Hip Ratio (WHR)	0.4	2.0	5.4	1.2	1.7	1.0	2.3	-1.1	-0.5
Number of treatments/medications taken	0.4	0.7	1.7	-1.3	-0.1	-1.1	0.3	-0.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.3	-0.0	-0.4	-1.1	1.0	0.7
Average weekly fortified wine intake	0.4	0.5	1.9	-0.3	-1.4	-0.0	-0.8	-0.6	-0.4
Maternal smoking around birth	0.4	0.6	1.7	0.1	0.4	-1.1	0.4	1.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	-0.0	0.2	0.4	1.2	-1.6	-1.1
Neuroticism score	0.4	0.9	1.8	0.7	-0.5	1.3	-0.1	1.1	1.4
Weight	0.4	2.0	4.6	1.8	2.1	0.4	1.1	1.2	1.2
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.2	-0.6	-0.2	-0.6	1.2	1.0
Falls in the last year	0.4	0.6	1.4	-0.7	-0.4	-0.6	-1.2	-0.7	-0.8
Impedance of arm (left)	0.4	1.9	3.0	-1.7	-0.2	-1.7	1.2	-1.3	-1.7
Breastfed as a baby	0.4	0.5	1.1	0.2	-1.0	0.9	-0.8	-0.8	-0.1
Arm predicted mass (right)	0.4	1.8	3.3	1.7	1.8	0.9	0.7	1.2	1.3
Number of self-reported non-cancer illnesses	0.4	0.6	1.6	-1.2	0.1	-1.3	-0.2	-0.3	-0.7
Arm fat-free mass (left)	0.4	2.3	4.5	2.1	1.8	1.1	0.6	1.4	1.6
Fractured/broken bones in last 5 years	0.4	0.5	2.5	-0.2	-0.4	0.1	-1.6	-0.3	-0.2
Supplements: Calcium	0.4	0.4	1.5	0.6	-0.3	1.2	-0.6	0.0	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	0.8	1.1	0.4	0.5	0.6	0.7
Schizophrenia (2018)	0.3	0.6	1.8	0.7	1.3	-0.4	1.0	0.1	-0.0
Major Depression (MDD)	0.3	0.3	1.0	0.4	0.5	-0.7	1.0	0.5	0.0
Ovarian Cancer	0.3	0.4	1.1	0.8	-0.2	1.1	0.5	-0.5	0.0
Age at First Birth	0.3	0.4	1.8	0.5	0.3	1.3	-0.2	-0.2	0.3
Lupus	0.3	0.4	0.8	0.8	0.1	0.3	-0.1	0.9	0.9
Blood Eosinophil Count	0.3	2.3	6.5	-0.3	1.2	-1.4	1.2	2.5	1.6
Blood White Count	0.3	1.9	6.0	1.0	0.2	0.2	0.5	2.4	2.0
BMI	0.3	2.0	4.2	1.7	0.9	0.2	0.9	2.0	1.7
Height	0.3	5.4	15.1	2.4	3.9	0.4	3.0	1.2	1.2
Vitamin and mineral supplements	0.3	0.5	0.9	0.8	0.8	0.2	1.0	-0.7	-0.4
Severe depression (siblings)	0.3	0.3	0.9	0.1	0.5	0.1	0.9	-0.7	-0.5
Body mass index (BMI)	0.3	1.2	2.2	1.5	1.4	0.3	0.4	1.2	1.2
Impedance of leg (left)	0.3	1.7	6.1	0.5	1.4	0.7	2.5	-0.9	-0.5
Diabetes (self-reported)	0.3	0.5	1.1	0.5	0.6	1.1	1.1	0.1	0.4
Medication: Ramipril	0.3	0.4	0.9	-0.2	1.0	-0.5	0.7	0.6	0.3
Impedance of arm (right)	0.3	1.3	2.0	-1.3	-0.5	-1.3	1.0	-1.1	-1.4
Time employed in main current job	0.3	0.3	0.9	-0.7	0.4	-0.5	0.9	0.3	-0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.1	1.8	1.3	1.0	-0.3	0.3	0.7
Prospective memory result	0.3	0.4	1.0	0.7	-0.1	0.8	-1.0	0.4	0.6
Lung cancer (father)	0.3	0.4	1.7	-0.0	0.1	-0.0	-1.3	0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.8	1.7	1.1	1.1	-0.6	0.3	0.8
Arm fat mass (right)	0.3	1.2	3.2	1.4	1.8	0.0	0.8	1.0	0.8
Loud music exposure frequency	0.3	0.3	1.0	-0.5	0.2	-1.0	0.4	0.6	0.1
Medication: Paracetamol	0.3	0.5	1.0	0.7	-0.3	0.6	0.5	1.0	1.0
Glaucoma (self-reported)	0.3	0.3	0.7	-0.4	-0.6	-0.5	-0.2	-0.7	-0.8
Gout (self-reported)	0.3	0.4	1.6	-0.1	1.2	-1.0	0.1	0.2	-0.1
Arm fat-free mass (right)	0.3	1.7	3.5	1.6	1.9	0.6	0.5	1.3	1.2
Comparative body size at age 10	0.3	0.7	2.6	0.5	-0.0	0.9	1.6	-0.7	-0.4
Migraine (self-reported)	0.3	0.3	0.8	-0.0	-0.7	0.3	-0.7	-0.9	-0.5
Mean time to correctly identify matches	0.3	0.5	2.4	0.1	0.7	-0.5	1.6	0.3	-0.0
Ever had bowel cancer screening	0.3	0.4	0.7	0.2	0.8	-0.8	0.5	0.8	0.4
Osteoporosis (self-reported)	0.3	0.3	0.7	-0.3	-0.2	-0.6	-0.8	0.8	0.5
Arm fat mass (left)	0.3	1.1	3.2	1.1	1.8	-0.2	0.9	0.8	0.6
Miserableness	0.3	0.5	1.6	0.8	-0.0	1.3	0.9	0.2	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.5	0.2	-0.5	0.6	1.2	0.2	0.2
Alcohol drinker status: Previous	0.3	0.3	0.9	0.4	0.7	-0.1	0.3	0.9	0.6
Arm predicted mass (left)	0.3	1.6	3.1	1.8	1.5	0.8	0.4	1.3	1.4
Respiratory disease	0.2	0.5	1.6	-0.3	-0.3	1.3	1.0	-0.3	0.1
Chronotype (morning person)	0.2	0.4	0.8	0.1	-0.6	0.5	0.9	0.8	0.8
Sensitivity / hurt feelings	0.2	0.3	1.1	0.4	-0.3	0.6	-1.1	-0.0	0.3
Diabetes (father)	0.2	0.3	0.6	0.0	-0.6	0.7	-0.8	-0.4	0.0
Impedance of leg (right)	0.2	1.2	4.0	-0.1	1.1	-0.2	2.0	-1.0	-0.9
Leg fat-free mass (left)	0.2	0.8	1.6	1.0	1.1	-0.1	0.1	1.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	0.4	0.3	0.8	0.9	0.0	0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.1	-1.0	0.6	-0.6	-0.2	0.0
Sitting height	0.2	1.3	2.3	-0.6	-1.5	0.1	-1.5	-1.4	-1.0
Leg predicted mass (left)	0.2	0.9	1.7	1.0	1.1	-0.2	0.2	1.3	1.0
Waist circumference	0.2	0.8	2.9	1.2	1.7	0.3	0.7	0.3	0.3
Nervous feelings	0.2	0.4	0.8	0.4	-0.8	0.9	-0.5	0.2	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	0.6	-0.3	1.0	0.6	-0.4	0.0
Arm fat percentage (right)	0.2	0.6	1.6	0.9	1.3	-0.2	0.7	0.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.2	-1.0	0.7	-0.4	-0.2	0.1
Number of live births	0.2	0.3	0.7	-0.5	0.4	-0.8	0.7	0.0	-0.3
Noisy workplace	0.2	0.3	0.7	-0.3	-0.1	-0.8	-0.7	-0.3	-0.6
Peak expiratory flow (PEF)	0.2	0.4	1.1	0.3	-0.3	0.3	-1.1	-0.8	-0.5
Medication: Omeprazole	0.2	0.3	1.0	-0.5	-0.3	-1.0	-0.4	0.5	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.3	-0.8	0.0	-0.8	-0.1	-0.1
Chest pain or discomfort	0.2	0.3	1.3	0.0	-1.1	0.5	0.0	-0.1	0.0
Whole body fat-free mass	0.2	1.0	1.7	1.2	1.3	0.3	0.1	1.1	1.1
Leg fat-free mass (right)	0.2	0.9	1.8	1.1	1.0	0.2	0.1	1.3	1.1
Arm fat percentage (left)	0.2	0.7	2.1	0.8	1.4	-0.4	0.9	0.6	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.3	0.6	0.8	0.9	-0.3	0.1
Asthma (self-reported)	0.2	0.3	1.4	-0.1	0.6	0.5	1.2	0.3	0.3
Smoking status: Current	0.2	0.3	0.5	0.1	-0.7	0.7	-0.7	0.1	0.3
Whole body water mass	0.2	0.9	1.5	1.2	1.2	0.3	0.0	1.1	1.0
Leg predicted mass (right)	0.2	0.9	1.8	1.2	1.0	0.2	0.1	1.4	1.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.6	-0.7	0.2	-0.3	-0.5	-0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.5	-0.7	-0.2	-0.1	-0.5	-0.6
Medication: Paracetamol	0.2	0.3	0.6	0.3	-0.8	0.4	-0.4	0.7	0.7
Basal metabolic rate	0.2	1.4	2.7	1.5	1.6	0.4	0.4	1.3	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.0	-0.3	-0.1	-1.0	0.3	0.2
Impedance of whole body	0.2	1.0	3.7	-0.5	0.5	-0.6	1.9	-0.9	-1.0
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.5	0.0
Primary Biliary Cirrhosis	0.1	0.1	0.5	-0.4	0.4	0.1	0.7	0.2	0.0
Systolic Blood Pressure	0.1	0.5	1.2	0.3	1.1	-0.3	0.5	0.9	0.7
Tanning	0.1	1.1	3.3	0.6	0.7	-0.9	-0.5	1.8	1.2
Angina	0.1	0.1	0.4	-0.3	-0.6	0.2	0.1	0.1	0.1
Medication: Co-codamol	0.1	0.1	0.5	0.2	0.2	-0.2	-0.1	0.7	0.4
Medication: Metformin	0.1	0.1	0.6	-0.1	0.8	0.2	0.4	0.1	0.1
Current tobacco smoking	0.1	0.2	0.3	0.3	-0.5	0.6	-0.4	0.4	0.5
High blood pressure (mother)	0.1	0.2	0.7	0.0	0.1	0.0	0.1	0.8	0.6
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.1	-0.4	0.2	-0.3	-0.4	-0.3
Trunk fat-free mass	0.1	0.7	1.3	1.1	1.2	0.4	-0.1	0.8	0.9
Hip circumference	0.1	0.5	1.1	1.0	1.1	0.1	-0.1	0.8	0.7
Asthma	0.1	0.3	1.0	-0.4	0.3	0.3	1.0	-0.2	-0.2
Trunk predicted mass	0.1	0.7	1.2	1.1	1.1	0.5	-0.2	0.8	0.8
Standing height	0.1	1.1	3.0	0.8	1.7	0.3	1.6	-0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.3	-0.7	0.2	0.1	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.3	0.3	-0.7	0.2	-0.1	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.2	-0.1	-0.5	0.4	0.6	0.3
Angina (self-reported)	0.1	0.1	0.5	-0.5	-0.7	-0.1	0.0	0.0	-0.1
Comparative height size at age 10	0.1	0.4	0.7	-0.7	-0.4	-0.6	-0.8	-0.5	-0.6
Family relationship satisfaction	0.1	0.2	0.4	0.3	0.4	0.5	0.6	-0.2	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.6	0.2	-0.6	0.3	-0.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.3	0.3	0.1
Guilty feelings	0.1	0.1	0.5	-0.0	-0.4	-0.0	0.7	-0.3	-0.4
Wears glasses or contact lenses	0.1	0.2	0.4	0.3	-0.2	0.6	0.2	-0.6	-0.2
Commuting to job workplace: Public transport	0.1	0.2	0.5	-0.6	-0.7	0.1	0.2	0.0	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.6	-0.1	0.2	-0.4	0.8	0.2	-0.0
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.5	-0.0	-0.1
Hair Pigment	0.0	1.2	5.8	-0.6	-0.7	-0.1	-2.4	-0.7	-0.5
Systolic blood pressure, automated reading	0.0	0.1	0.5	0.2	0.7	-0.1	-0.4	0.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.0	-0.0	-0.1

Hub : Genes

GATS

Models

Trait associations