Hub : Genes

PRC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.1143 0.0429 3.6e-03 -0.004 NA -0.004 NA -0.004 7.5e-01 NA 0.85000 NA 0.7800
2 GTEx Stomach 0.4320 0.1160 5.5e-03 -0.006 NA -0.006 NA -0.006 1.0e+00 NA 0.92000 NA 0.9200
3 GTEx Testis 0.2190 0.0600 9.6e-05 0.114 NA 0.029 NA 0.001 9.3e-06 NA 0.01800 NA 0.2900
4 METSIM Adipose 0.0422 0.0200 1.3e-02 0.030 0.004 0.000 0.008 0.006 2.3e-05 0.07000 0.35000 2.1e-02 0.0400
5 YFS Blood 0.0358 0.0114 4.0e-05 0.020 0.009 0.009 0.012 0.010 2.6e-07 0.00056 0.00056 4.2e-05 0.0002
6 TCGA Uterine Corpus Endometrial Carcinoma 0.4880 0.1500 1.9e-03 0.035 0.076 0.025 NA 0.078 3.7e-02 0.00390 0.06800 NA 0.0035

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 3.3 1.2 1.8 0.7 0.2 0.3 -0.4
Bipolar Disorder or Schizophrenia 1.5 3.6 10.5 1.1 1.5 3.2 1.8 1.8 -1.2
Depressed Affect (Nagel 2018) 0.2 0.5 0.9 -0.3 -0.9 -0.6 -0.9 -0.5 0.7
Depression (Nagel 2018) 0.6 1.0 5.5 0.3 -0.2 -2.3 -0.1 -0.4 0.0
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.8 -1.4 -0.9 -1.0 -2.0 -1.9 0.2
Neuroticism (Nagel 2018) 0.5 1.3 3.3 0.5 -1.8 0.5 -1.2 -0.9 1.2
Schizophrenia (2018) 1.8 3.8 10.7 0.5 0.5 3.3 2.2 2.1 -1.5
Schizophrenia vs Biploar Disorder 1.7 2.2 9.4 -1.9 -3.1 -0.0 -0.7 0.0 -0.3
Worry (Nagel 2018) 1.0 2.1 7.6 1.2 -2.8 0.7 -1.7 -0.5 0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -1.2 0.1 -1.0 -0.5 -1.2 0.3
Alzheimer’s Disease (in father) 0.6 0.6 1.9 -0.6 0.6 -0.9 1.4 0.0 0.7
Alzheimer’s Disease (including proxy) 0.9 1.4 3.5 -1.3 0.8 -1.9 0.8 -1.2 0.7
Crohns Disease (2017) 0.3 0.7 1.7 -0.9 0.3 -1.3 -1.1 -0.2 0.3
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 -0.5 0.0 -0.7 -0.2 0.8 -0.2
Ulcerative Colitis (UC) 0.2 0.4 1.2 -0.3 -0.7 -0.3 0.6 1.1 -0.2
Major Depression (MDD) 2.0 2.4 9.7 3.1 1.0 -0.6 -0.1 -1.5 0.9
Reaction Time 0.2 0.4 1.6 0.3 0.2 1.3 0.7 -0.4 0.5
Verbal and Numeric Reasoning (VNR) 0.8 1.9 6.2 -1.0 -1.0 -0.9 -2.5 -1.5 -0.0
Breast Cancer 1.2 2.8 6.9 -0.8 -1.8 -1.9 -2.6 -1.5 -0.5
Ovarian Cancer 1.2 1.6 3.2 1.2 -1.4 -1.3 -1.8 -0.8 -0.6
Prostate Cancer 0.4 0.6 1.5 0.2 -0.9 1.1 1.2 -0.1 -0.3
Age at First Birth 0.8 1.2 2.2 0.4 -0.1 1.0 -1.4 1.5 -1.3
Bipolar Disorder (2011) 0.3 0.2 0.9 -0.4 1.0 0.5 -0.4 0.0 -0.2
Body Mass Index (BMI) (2010) 0.4 0.5 1.2 0.2 -1.1 -0.7 -0.1 0.8 -0.8
Coronary Artery Disease (CAD) 0.7 0.8 2.0 -0.9 -0.5 -1.4 1.1 -0.9 0.0
Crohns Disease (2012) 0.6 1.0 2.9 -1.2 0.6 -1.2 -1.7 -0.3 0.0
Mean Putamen Volume 0.7 0.8 2.9 1.7 -0.1 0.1 1.1 0.6 -0.3
Fasting Glucose 0.7 0.8 3.1 -0.4 -1.1 -1.8 -0.3 -0.2 -0.3
HbA1C 3.1 3.4 11.4 0.9 -0.4 0.2 -0.5 3.4 -2.8
HDL Cholesterol 0.6 1.0 2.7 1.6 0.4 1.6 -0.8 0.2 -0.5
LDL Cholesterol 0.7 1.2 2.0 1.4 0.2 0.7 -1.1 1.2 -1.4
Lupus 1.0 1.5 5.2 0.1 -0.4 -0.9 0.6 -1.6 2.3
Neuroticism (2016) 0.9 1.3 3.3 -1.0 -1.8 -0.7 0.5 -1.3 1.0
Primary Biliary Cirrhosis 0.7 1.0 2.3 0.9 0.6 -0.2 1.4 -1.5 0.8
Rheumatoid Arthritis 0.8 1.1 2.1 0.3 -1.0 1.0 -0.8 -1.2 1.4
Schizophrenia (2014) 1.2 2.6 5.8 0.5 0.0 2.4 0.8 1.7 -2.4
Triglycerides 0.4 0.6 1.2 -0.8 0.3 1.1 -1.1 -0.0 -0.6
Type 2 Diabetes (T2D) (2012) 2.8 3.3 10.7 -1.3 -0.3 -3.3 1.2 -0.0 2.4
Ulcerative Colitis 0.5 0.7 1.2 0.8 -1.1 0.5 0.8 1.0 -0.5
Blood Eosinophil Count 0.8 6.5 10.6 -2.5 -2.2 -3.0 2.3 -1.6 3.2
Blood Platelet Count 0.7 8.5 27.8 -1.4 0.8 3.0 5.3 0.4 3.4
Blood Red Count 0.2 1.5 5.4 0.9 0.0 -2.3 -0.3 -1.4 0.8
Blood White Count 0.0 0.2 0.7 0.0 0.2 -0.4 0.6 0.0 0.9
Heel T-Score 0.9 7.2 15.4 -3.9 0.0 -2.9 -2.1 -3.0 2.5
BMI 0.9 5.4 13.3 -1.5 3.2 -3.6 1.7 -1.1 1.4
Height 0.1 1.8 8.5 2.9 1.0 -0.3 0.5 -0.1 1.1
Waist Hip Ratio (WHR) 0.4 2.0 6.9 -0.7 -1.6 2.6 0.8 0.8 -0.7
Systolic Blood Pressure 0.8 3.8 15.2 1.8 -1.1 1.8 -3.9 -0.3 0.0
Smoking Status 0.9 2.1 3.8 -1.9 0.3 -2.0 -0.1 -1.9 1.2
Allergy or Eczema 3.4 9.0 33.8 -5.8 -3.1 -1.7 -0.5 -1.3 2.5
Cardiovascular Disease 0.3 1.0 4.0 -2.0 0.4 -1.1 -0.5 -0.6 0.3
Hypothyroidism (self reported) 0.9 2.1 4.8 -2.2 0.8 -1.6 -2.0 -0.5 0.8
Respiratory disease 1.1 2.5 7.3 0.0 0.7 -2.7 1.9 0.2 1.9
Type 2 Diabetes (T2D) (2018) 1.2 2.3 7.4 -0.3 1.3 -2.7 0.2 -1.6 1.3
Lung FEV1/FVC ratio 0.2 1.3 7.1 0.1 2.7 -0.1 0.1 0.6 -0.0
Lung FVC 0.1 0.4 1.6 0.0 -0.2 0.1 -0.8 0.6 -1.3
Neuroticism 0.4 1.1 3.2 0.1 -1.8 -0.2 -0.9 -1.1 1.1
Chronotype (morning person) 0.6 1.4 4.6 -2.2 -0.2 1.2 -1.3 -0.6 -0.0
Hair Pigment 0.1 2.9 7.8 -0.3 -0.9 2.8 -0.1 1.6 -2.5
Tanning 0.2 3.0 9.5 -2.3 -1.0 -3.1 0.4 -1.0 1.1
Hand grip strength (left) 0.5 1.4 5.4 2.3 -0.2 -0.9 -0.2 -0.1 -1.4
Number of treatments/medications taken 1.7 3.1 10.4 -1.2 1.0 -3.2 0.8 -1.4 1.7
Average weekly spirits intake 0.5 0.7 2.7 0.9 -0.2 1.6 0.5 0.5 -0.1
Sensitivity / hurt feelings 0.7 1.3 2.5 0.7 -0.7 -0.7 1.4 -1.6 1.3
Frequency of depressed mood in last 2 weeks 0.5 0.6 1.6 0.2 -0.0 -1.1 0.9 0.6 -1.2
Hearing difficulty/problems: Yes 0.4 0.6 2.1 -0.0 1.5 -0.8 0.3 -0.2 0.8
Relative age of first facial hair 0.7 1.4 3.0 1.6 0.1 1.2 1.7 1.2 0.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.7 -0.6 -0.1 -0.8 -0.7 -1.3 0.4
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.7 0.2 -0.7 0.6 -0.0 1.3 -1.3
Ever had hysterectomy (womb removed) 1.3 1.5 4.1 0.7 -1.5 0.3 -2.0 -1.4 0.2
Systolic blood pressure, automated reading 1.0 3.0 12.7 1.5 -0.3 1.2 -3.6 -1.3 0.2
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 3.4 -1.1 0.9 -1.4 -1.8 -0.2 -1.1
Angina 1.5 2.0 4.2 -1.9 -0.6 0.0 -1.3 -2.0 1.5
Medication for hormone replacement therapy 0.5 0.5 1.0 1.0 0.5 -0.8 1.0 0.5 -0.3
Vitamin and mineral supplements 1.6 2.1 5.0 -2.2 0.3 0.0 -1.5 1.3 -1.9
Supplements: Zinc 0.5 0.5 1.5 0.3 -1.2 -0.7 0.9 -0.2 0.2
Medication: Co-codamol 0.8 0.9 1.7 -0.8 1.0 -1.3 1.1 0.3 -0.9
Medication: Metformin 0.8 1.1 1.8 -0.9 1.3 -1.1 0.0 -1.3 1.1
Diabetes (father) 1.1 1.3 4.7 -1.5 0.7 -2.2 0.4 -0.3 0.6
Diabetes (mother) 1.1 1.4 2.6 -0.8 -1.6 -1.0 0.4 1.5 -1.2
Severe depression (siblings) 1.3 1.4 3.2 -0.5 -1.0 -0.8 -1.6 -1.8 0.8
Pack years adult smoking proportion 0.8 1.2 2.8 0.8 1.7 -0.3 1.4 1.1 0.6
Impedance of leg (right) 0.5 2.5 4.5 -0.3 -2.1 1.6 -2.0 1.1 -1.6
Leg fat-free mass (left) 0.4 2.3 4.2 0.7 1.8 -2.0 1.7 -0.8 1.5
Trunk fat percentage 0.5 2.0 4.0 -0.5 1.6 -1.4 1.6 -0.9 2.0
Hand grip strength (right) 0.7 1.9 9.4 3.1 0.8 -1.0 -0.2 0.1 -0.7
Townsend deprivation index at recruitment 1.7 2.3 7.7 -0.2 0.2 -1.4 1.9 -0.9 2.8
Current tobacco smoking 0.7 1.1 2.5 -1.1 0.0 -1.1 -0.4 -1.6 1.1
Average weekly fortified wine intake 0.5 0.5 1.2 0.8 -1.0 0.0 1.1 -0.1 -0.6
Maternal smoking around birth 0.7 1.0 3.4 -0.2 -1.3 -1.8 0.1 0.6 0.9
Fed-up feelings 0.2 0.3 1.0 -0.4 -0.6 -0.4 0.1 -0.3 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.6 0.7 0.1 -1.6 0.7 0.2 -0.1
Relative age voice broke 0.9 1.4 4.7 1.3 0.2 1.0 2.2 0.7 0.4
Taking other prescription medications 2.6 3.9 13.9 -1.7 1.0 -3.7 0.1 -1.8 1.6
Age when periods started (menarche) 0.5 1.2 4.7 2.2 0.8 0.5 -1.0 0.5 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.8 0.8 0.3 -0.5 -0.6 -1.3 0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.8 8.7 -3.0 0.9 -1.9 -2.8 -1.2 0.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 0.3 0.8 1.1 0.7 0.3 -0.1
Qualifications: CSEs or equivalent 0.7 0.9 2.3 1.5 -1.1 -0.1 0.3 1.3 -0.1
Serious illness, injury or assault to yourself 1.8 2.2 4.2 2.0 -0.3 2.0 0.3 -1.7 1.3
High blood pressure 0.3 1.0 2.2 -1.0 0.2 -0.9 -0.7 -1.1 1.5
Hayfever, allergic rhinitis or eczema 3.4 7.4 26.0 -5.1 -3.5 -1.6 0.1 -0.9 1.7
Multivitamins +/- minerals 0.5 0.7 2.0 0.5 -0.8 -0.8 1.4 -0.3 0.6
Stomach or abdominal pain in last month 2.6 3.2 6.3 -1.1 -0.1 -2.5 0.8 -2.2 2.5
Supplements: Glucosamine 0.8 1.0 3.6 1.4 1.9 -0.6 -0.3 -0.4 0.0
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 3.4 0.1 -1.8 -0.2 -0.4 -1.9 1.4
Medication: Atenolol 0.5 0.7 1.6 -1.3 -0.1 1.1 -1.0 -0.2 0.4
Medication: Levothyroxine sodium 0.5 0.8 2.3 -0.3 1.4 -0.2 -1.5 0.5 -0.1
Sitting height 0.1 0.9 2.3 1.0 -0.7 -1.5 0.2 -0.6 1.1
Chronic bronchitis/emphysema (father) 1.0 1.1 2.7 1.1 0.9 0.0 0.3 1.7 -1.4
High blood pressure (mother) 1.0 1.5 4.5 1.2 0.1 -0.8 -2.1 -1.4 0.1
Body mass index (BMI) 0.8 3.4 7.4 -0.7 2.7 -2.5 1.3 -1.2 1.9
Impedance of leg (left) 0.6 3.1 5.4 -0.6 -2.3 1.6 -1.6 1.7 -2.2
Leg predicted mass (left) 0.4 2.2 4.0 0.7 1.7 -2.0 1.7 -0.7 1.5
Trunk fat mass 0.7 2.8 4.8 -0.2 2.1 -1.9 1.7 -0.9 2.2
Waist circumference 0.8 2.7 7.7 -0.2 2.8 -1.9 1.4 -0.8 1.5
Number of incorrect matches in round 1.3 2.2 8.3 -1.0 0.9 -0.7 2.9 0.7 1.5
Past tobacco smoking 0.3 0.5 1.3 0.5 -0.6 -0.1 0.9 1.1 -0.7
Alcohol usually taken with meals 0.2 0.4 0.8 0.3 -0.9 0.9 -0.8 -0.0 -0.3
Nervous feelings 1.1 2.0 3.0 1.1 -1.2 1.7 -0.9 1.6 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.9 0.9 0.1 -0.5 0.4 0.8 -1.4
Hearing difficulty/problems with background noise 0.7 1.1 3.9 0.7 2.0 -0.7 -0.6 -1.0 0.4
Hair/balding pattern: Pattern 2 1.1 1.4 3.4 1.8 1.7 1.3 0.6 0.6 -0.4
Had menopause 0.6 0.8 2.5 1.4 0.0 -0.2 -1.6 -0.1 0.3
Had other major operations 1.9 2.4 5.2 -0.2 0.4 -2.3 0.8 -1.8 2.2
Forced vital capacity (FVC) 0.2 0.8 1.8 -0.1 -1.3 -1.3 -0.8 0.3 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 6.5 -2.6 1.1 -2.0 -2.2 -1.0 0.5
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 3.7 -1.9 -1.2 0.8 -0.2 1.2 -1.7
Qualifications: None of the above 0.8 1.7 7.0 1.5 2.6 -0.7 0.1 0.2 0.4
Financial difficulties in last 2 years 1.2 1.6 5.0 -1.2 -0.8 -2.2 1.1 1.1 0.2
Mouth/teeth dental problems 0.2 0.4 1.2 0.8 0.5 -0.1 -0.4 -1.1 0.1
Heart attack 0.5 0.6 1.3 -0.1 -0.1 0.9 -0.7 -1.2 0.9
Allergy 2.0 4.7 12.7 3.6 2.2 2.1 -1.4 0.6 -1.9
Pain all over the body in last month 1.9 2.1 3.4 -1.6 -0.5 -1.8 1.0 -1.5 1.7
Diabetes (self-reported) 1.0 1.6 4.8 -1.2 1.7 -2.2 0.0 -0.3 0.5
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 10.0 -2.8 -1.7 -3.2 -0.0 -0.3 0.1
Medication: Ramipril 0.6 0.7 1.9 -1.4 0.0 -0.9 -0.8 -0.7 0.8
Medication: Simvastatin 0.4 0.6 2.8 -1.7 0.3 0.6 0.4 0.4 0.5
Fluid intelligence score 1.0 2.1 5.5 -0.9 -0.8 -1.5 -2.4 -1.5 1.2
Illnesses of siblings 1.5 2.2 3.9 0.9 -2.0 1.5 1.3 1.6 -1.4
Neuroticism score 0.3 0.7 3.1 -0.1 -1.8 0.5 -0.4 -0.4 -0.6
Weight 0.7 3.4 6.4 0.3 2.5 -2.4 1.6 -1.0 2.1
Impedance of arm (right) 0.6 2.6 9.9 -1.2 -3.1 1.7 -0.2 0.8 -0.8
Arm fat percentage (right) 0.8 3.3 4.9 -1.6 1.7 -2.2 1.8 -1.2 2.2
Trunk fat-free mass 0.3 2.0 4.4 0.9 1.9 -2.1 0.5 -0.8 1.5
Hip circumference 1.1 4.8 12.2 0.1 3.2 -3.5 0.9 -1.5 1.8
Time employed in main current job 0.1 0.1 0.5 0.3 -0.3 0.7 0.3 0.2 -0.2
Alcohol intake versus 10 years previously 0.6 0.8 1.4 -1.1 -0.4 -1.2 0.0 -1.1 1.0
Father’s age at death 1.5 2.1 10.0 -0.5 3.2 -1.0 -0.5 -0.4 0.9
Worrier / anxious feelings 0.9 1.7 6.4 -0.8 -2.5 1.1 0.7 1.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.4 0.2 -0.1 -0.8 1.8 0.7 -0.2
Falls in the last year 1.4 1.9 5.0 -0.0 0.4 -2.2 1.8 -1.0 1.5
Hair/balding pattern: Pattern 3 0.7 1.0 3.8 -1.9 0.1 -0.5 -0.8 -0.8 0.9
Number of live births 0.3 0.5 0.8 -0.8 -0.6 -0.7 -0.9 -0.7 0.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.8 0.3 -0.4 -1.3 -0.8 0.5 -1.3
Pulse rate 0.4 0.7 1.8 0.6 -1.2 -1.3 -0.1 0.3 0.8
Happiness 0.3 0.4 1.0 -0.4 -0.5 -1.0 0.4 -0.5 0.6
Noisy workplace 0.4 0.6 1.5 0.4 -0.8 1.2 0.0 1.0 -0.3
Qualifications: A levels/AS levels or equivalent 1.2 2.7 9.1 -0.7 -3.0 -1.6 -0.9 -1.5 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.5 -1.1 0.2 -1.9 0.1 -0.9 1.5
Mouth/teeth dental problems: Dentures 0.3 0.6 1.4 -1.2 -0.6 0.5 0.8 0.9 -0.2
Asthma 1.0 1.9 5.7 -0.7 0.0 -1.4 2.4 -0.1 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 -0.2 -0.5 -1.0 -0.2 1.1 -0.8
Medication: Cholesterol lowering 0.9 1.5 5.2 -0.9 -0.2 -0.4 -0.3 -1.6 2.3
Depression (self-reported) 1.1 1.4 3.9 -0.6 0.4 -2.0 1.8 0.5 -0.6
Medication: Lansoprazole 1.2 1.3 2.5 -1.3 1.6 -0.8 -0.2 -1.3 1.2
Prospective memory result 0.2 0.3 1.0 0.3 -0.3 -0.7 1.0 -0.3 0.3
Lung cancer (father) 0.7 0.8 1.9 -0.5 0.7 1.0 1.4 0.8 -0.6
Illnesses of mother 1.9 2.3 4.4 0.4 1.0 2.1 1.9 2.0 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.3 0.4 0.3 -0.8 -0.4 1.1 -0.9
Pulse wave Arterial Stiffness index 0.3 0.4 1.4 0.3 -0.7 1.2 0.1 0.2 0.1
Impedance of arm (left) 0.5 2.3 8.9 -0.3 -3.0 1.8 0.1 0.8 -0.9
Arm fat mass (right) 0.8 3.2 6.5 -0.8 2.1 -2.5 1.5 -1.3 2.0
Trunk predicted mass 0.4 2.1 4.7 0.9 1.9 -2.2 0.5 -0.8 1.5
Standing height 0.1 1.2 6.0 2.5 -0.0 -0.2 0.5 0.5 0.7
Length of working week for main job 0.3 0.3 0.8 0.3 -0.1 0.8 0.9 -0.3 0.4
Exposure to tobacco smoke at home 0.7 0.8 1.5 -1.0 -1.2 -1.0 -0.2 -1.1 0.1
Breastfed as a baby 2.6 3.3 11.2 -0.1 -0.8 -1.0 -1.3 -2.2 3.4
Tense / ‘highly strung’ 1.0 1.7 3.4 0.7 -1.9 -1.6 -0.0 -1.2 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.6 -0.6 -1.3 -0.9 1.2 -0.4 0.7
Hair/balding pattern: Pattern 4 1.7 4.2 17.7 -4.2 -2.2 -0.3 -1.4 -0.4 -0.1
Birth weight of first child 1.8 3.4 7.3 -1.9 -1.4 -0.7 2.7 2.6 -0.5
Peak expiratory flow (PEF) 0.4 0.8 2.7 0.9 0.1 -1.6 -0.3 0.7 -0.9
Pulse wave reflection index 1.1 1.4 3.6 1.5 1.9 1.5 -0.1 -0.1 0.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.7 0.1 -0.8 -1.1 1.9 -0.0 1.2
Loud music exposure frequency 0.4 0.5 1.9 0.1 -0.2 -0.5 0.1 -1.4 0.8
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.1 -0.6 -1.4 -0.3 -1.0 -1.5 0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.3 -0.8 -0.9 0.7 -0.4 1.1 -0.5
Blood clot in the leg (DVT) 0.2 0.3 1.3 0.4 -0.1 -0.1 1.1 0.1 0.3
Medication: Paracetamol 0.2 0.3 0.9 -0.4 0.4 -0.6 -1.0 0.1 -0.6
Headache pain in last month 0.3 0.6 1.6 0.1 -1.0 -1.3 0.8 0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 6.3 1.0 0.1 0.9 0.7 1.8 -2.5
Glaucoma (self-reported) 2.2 2.6 9.2 0.4 -0.9 -0.8 -1.1 -3.0 1.9
Gout (self-reported) 0.9 1.3 4.9 -0.7 -0.7 2.2 0.0 -0.8 1.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.7 -1.9 0.8 -1.6 -1.7 -0.3 0.4
Medication: Amlodipine 1.0 1.4 5.8 0.0 -0.9 -2.4 -1.2 0.2 0.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 7.9 -0.5 -0.5 -1.3 2.8 0.8 0.8
Birth weight 0.8 1.8 4.4 1.5 -0.2 0.7 2.1 1.6 -1.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.4 -1.5 -0.3 -1.5 0.8 -0.4 0.8
High blood pressure (siblings) 1.5 2.2 4.5 0.5 1.9 -0.6 -1.6 -2.1 1.3
Forced vital capacity (FVC), Best measure 0.1 0.5 1.1 0.2 -0.6 -1.0 -0.0 1.0 -0.7
Body fat percentage 0.6 2.5 4.3 -0.8 1.8 -1.8 1.6 -1.0 2.1
Leg fat percentage (right) 0.9 3.2 6.2 -1.3 1.8 -2.5 1.1 -1.1 2.3
Arm fat-free mass (right) 0.4 2.3 4.7 1.4 2.0 -2.2 0.7 -0.7 1.4
Exposure to tobacco smoke outside home 2.2 2.9 5.8 1.0 0.9 -2.4 -1.2 -2.0 2.0
Comparative body size at age 10 0.3 0.7 3.4 -1.9 0.7 -0.2 -0.3 -0.6 0.3
Number of full brothers 0.5 0.6 2.1 0.3 0.9 -1.4 0.6 -0.4 0.3
Worry too long after embarrassment 0.3 0.5 0.9 -0.4 -0.0 0.9 0.4 0.9 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 4.7 0.2 -0.5 -1.1 1.5 -0.4 2.2
Wheeze or whistling in the chest in last year 0.7 1.2 2.9 -0.4 0.0 -1.2 1.7 -0.8 1.5
Number of children fathered 1.7 1.9 5.4 0.4 -1.1 -1.5 0.4 -1.5 2.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.8 -0.5 0.2 -0.1 -1.7 -0.2 0.6
Age at first live birth 1.1 2.0 6.2 -1.3 -1.0 1.1 -2.5 0.4 -1.4
Pulse wave peak to peak time 0.4 0.4 1.9 0.0 0.9 -1.4 0.0 -0.1 -0.1
Health satisfaction 1.6 2.1 6.4 -1.2 -0.5 -1.6 -0.1 -1.3 2.5
Shortness of breath walking on level ground 0.4 0.5 0.9 0.3 0.7 0.5 -0.5 -1.0 0.9
Qualifications: College or University degree 0.3 0.8 2.8 -1.7 -1.3 -0.4 0.1 -0.5 -0.0
Eye problems/disorders: None of the above 0.6 0.7 2.2 -0.5 1.0 0.1 0.1 -0.6 1.5
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.2 -0.2 -0.8 0.5 -0.3 1.1 -0.4
Emphysema/chronic bronchitis 0.8 0.9 1.4 1.1 -0.8 0.1 1.2 1.2 0.7
Medication for pain relief, constipation, heartburn 0.9 1.6 4.8 0.7 -0.9 2.2 -0.0 0.8 -1.7
Neck or shoulder pain in last month 0.9 1.2 3.1 0.2 1.4 -1.8 -0.4 -1.1 0.9
Medication: Blood pressure 0.5 0.8 2.0 -1.4 -0.5 -0.0 -0.9 -0.8 1.1
Angina (self-reported) 1.4 1.9 3.7 -1.9 -0.5 0.4 -1.4 -1.8 1.3
Migraine (self-reported) 0.8 1.0 5.2 0.2 2.3 -0.5 0.4 -0.4 0.4
Medication: Ibuprofen 0.7 0.8 2.1 0.0 -0.1 -1.4 0.6 1.2 -1.0
Medication: Allopurinol 0.6 0.9 2.0 -0.8 -0.1 0.6 1.4 -0.5 1.4
Medication: Omeprazole 2.0 2.3 5.1 1.7 0.9 -2.3 1.7 -1.2 0.9
Medication: Seretide 50 evohaler 1.4 1.6 3.7 1.9 0.3 0.7 1.8 1.4 0.2
Mean time to correctly identify matches 0.3 0.6 1.1 0.4 1.0 0.8 0.9 -0.3 1.0
Heart disease (mother) 0.8 0.9 3.5 0.5 0.3 -0.9 -0.1 -1.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 -0.4 -0.5 0.1 -0.7 -0.2 -0.2
Whole body fat mass 0.7 3.1 4.9 -0.2 2.2 -2.2 1.7 -1.0 2.1
Leg fat mass (right) 0.7 2.8 6.1 -0.7 2.0 -2.5 1.4 -0.9 1.9
Arm predicted mass (right) 0.5 2.4 5.2 1.6 2.3 -2.0 0.6 -0.5 1.3
Pulse rate, automated reading 0.3 0.9 3.4 -0.1 -1.9 -0.7 -1.1 0.5 0.1
Alcohol intake frequency. 0.5 1.1 4.3 -0.5 0.5 -0.7 2.1 -0.5 1.2
Comparative height size at age 10 0.4 2.4 9.5 3.1 0.6 -1.5 0.9 -0.5 1.0
Number of full sisters 0.5 0.6 1.6 0.5 -0.5 -0.0 -0.0 -1.2 1.3
Suffer from ‘nerves’ 0.5 0.7 1.7 -0.0 -1.3 -0.6 -1.1 -0.9 -0.4
Overall health rating 1.7 3.7 11.9 -0.7 0.5 -3.5 0.9 -2.3 1.8
Chest pain or discomfort 0.7 1.0 2.3 -0.5 -0.8 -1.0 -0.8 -1.5 1.2
Had major operations 1.0 1.2 2.5 -0.7 -1.6 -0.9 0.1 -1.5 1.1
Age at last live birth 0.4 0.6 2.6 -1.6 -0.2 -0.3 -0.6 -0.4 0.6
Family relationship satisfaction 0.3 0.4 1.7 -0.6 -1.3 -0.4 0.3 0.3 -0.1
Leg pain on walking 0.7 0.9 2.8 -1.3 -0.7 -0.0 0.6 1.7 -0.5
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.7 8.5 -0.3 -0.8 1.0 1.8 2.9 -1.8
Commuting to job workplace: Car/motor vehicle 1.6 1.8 3.7 0.7 -1.8 1.9 -0.3 1.3 -1.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 -0.7 -0.3 0.5 0.6 0.8 -0.7
Medication: Aspirin 2.2 2.9 7.6 -1.1 1.4 -1.1 -1.1 -2.1 2.8
Supplements: Vitamin C 2.4 2.8 7.7 1.9 0.1 -1.0 0.3 -2.1 2.8
Knee pain experienced in last month 0.7 1.1 2.6 1.1 1.2 -1.6 0.8 -0.0 0.9
Hypertension (Self-reported) 0.4 1.0 3.1 -0.7 0.7 -0.8 -0.5 -1.1 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.2 0.7 1.5 -0.9 -0.4 -0.9 -0.3
Illnesses of father: Heart disease 1.4 2.0 3.5 -0.4 -1.2 -1.8 -0.4 -1.9 1.8
Illnesses of siblings: Diabetes 2.7 3.3 10.6 -1.0 1.7 -3.3 -0.2 -2.1 1.2
Smoking status: Previous 0.5 0.8 3.3 0.0 1.8 0.2 -0.5 -0.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.1 4.8 -0.0 -0.4 -2.2 0.9 1.0 -0.4
Whole body fat-free mass 0.4 2.2 4.4 1.0 2.0 -2.1 0.9 -0.8 1.5
Leg fat-free mass (right) 0.4 2.1 3.6 0.8 1.8 -1.9 1.9 -0.4 1.2
Arm fat percentage (left) 0.7 2.9 4.2 -1.3 1.7 -2.0 1.8 -1.2 2.1
Average weekly red wine intake 0.3 0.4 1.0 1.0 -1.0 -0.0 -0.1 -0.0 0.7
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.9 -0.3 0.0 -0.2 0.2 -0.9 1.0
Mood swings 0.1 0.1 0.3 0.3 0.0 0.0 -0.1 -0.4 0.5
Loneliness, isolation 0.5 0.7 3.5 -0.5 -0.4 -0.2 1.9 0.2 0.3
Long-standing illness, disability or infirmity 2.8 4.2 8.1 -0.7 1.7 -2.5 -0.6 -2.7 2.9
Ever had bowel cancer screening 3.5 4.1 10.1 1.3 -0.5 -1.8 -2.0 -3.2 2.4
Diabetes diagnosed by doctor 1.3 2.1 7.1 -1.0 1.4 -2.7 -0.9 -1.2 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.1 -1.2 -0.4 -1.4 0.1 -0.5 0.8
Friendships satisfaction 1.1 1.4 4.5 -0.8 -0.9 -1.4 2.1 0.5 0.0
Qualifications: nursing, teaching 0.3 0.5 2.3 -0.4 0.1 -1.5 -0.5 -0.2 -0.2
Commuting to job workplace: Walk 1.5 1.7 4.2 -0.1 0.6 -2.0 1.5 -0.1 1.8
Eye problems/disorders: Cataract 1.3 1.5 3.3 0.4 -1.2 -1.8 1.6 1.0 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.4 0.6 -0.3 -1.2 0.2 -0.2 0.6
Medication for cholesterol 0.6 1.0 5.3 -0.1 -2.3 0.1 -0.5 -0.4 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.7 0.0 0.8 -0.6 0.5 0.5 -0.8
Back pain experienced in last month 0.4 0.6 2.7 -0.3 0.5 -1.6 0.3 -0.3 -0.4
Mineral and other dietary supplements 2.4 3.2 6.3 -2.4 -1.0 1.6 0.4 2.5 -1.9
Breast cancer (self-reported) 0.3 0.3 0.5 0.6 -0.7 0.6 0.6 0.6 -0.2
Asthma (self-reported) 1.0 1.9 5.0 -0.9 0.2 -1.2 2.0 -0.5 2.2
Osteoporosis (self-reported) 2.5 3.1 12.6 -0.6 -1.6 -0.6 3.5 -0.4 1.6
Osteoarthritis (self-reported) 0.8 1.0 1.9 0.4 1.1 -1.2 -0.1 -1.2 1.4
Medication: Aspirin 1.9 2.5 4.5 -1.0 1.8 -1.1 -1.1 -1.9 2.1
Medication: Gliclazide 0.4 0.4 2.0 -1.4 -0.2 -0.7 0.0 0.4 -0.1
Illnesses of father: None of the above (group 1) 2.3 2.9 13.8 0.9 0.1 3.7 0.1 0.3 -1.6
Smoking status: Current 0.8 1.3 2.5 -1.3 -0.1 -1.6 -0.1 -1.5 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.9 0.6 -1.4 -1.1 0.3 -0.7 0.3
Whole body water mass 0.4 2.4 4.8 1.0 2.0 -2.2 1.1 -0.8 1.6
Leg predicted mass (right) 0.4 2.2 3.9 0.7 1.9 -2.0 1.9 -0.4 1.2
Arm fat mass (left) 0.8 3.2 5.8 -0.5 2.4 -2.4 1.6 -1.0 1.9
Number of self-reported non-cancer illnesses 2.9 5.0 10.6 -1.8 1.6 -3.2 2.3 -1.7 2.4
Average weekly champagne plus white wine intake 0.2 0.2 0.6 -0.1 -0.2 0.7 0.7 -0.1 0.5
Miserableness 0.2 0.3 1.2 0.1 -1.1 -0.6 0.5 -0.3 -0.1
Guilty feelings 0.4 0.5 1.1 0.7 -1.0 1.1 0.3 -0.7 0.1
Wears glasses or contact lenses 0.9 1.0 3.2 0.5 0.6 -1.4 0.7 1.8 0.4
Ever taken oral contraceptive pill 0.9 1.0 4.3 -0.6 -2.1 0.5 0.0 -0.5 0.8
Hearing aid user 2.0 2.3 4.7 2.2 1.2 1.5 0.4 1.9 -1.3
Mother’s age at death 0.5 0.6 2.6 -0.1 -0.8 -1.6 -0.4 -0.1 0.1
Financial situation satisfaction 0.6 0.7 1.7 -0.1 -0.4 -1.0 0.8 -1.1 1.3
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.0 0.5 -0.3 -0.1 -1.0 -0.3 0.6
Commuting to job workplace: Public transport 1.6 1.9 4.7 -0.1 1.0 -2.2 1.3 -1.4 1.4
Eye problems/disorders: Glaucoma 1.3 1.6 5.6 0.3 -0.8 -0.4 -0.8 -2.4 1.5
Medication: Blood pressure 0.5 1.0 4.9 0.3 2.2 -0.4 -0.6 -0.2 0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 3.0 -0.3 1.7 -1.4 1.0 -0.5 0.9
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.1 2.0 -0.2 -1.1 -0.6 -1.7 1.8
High cholesterol (Self-reported) 0.2 0.4 1.4 -0.3 0.5 1.2 0.8 -0.3 0.4
Medication: Bendroflumethiazide 0.4 0.6 1.2 0.2 0.9 -1.1 0.6 0.9 -0.4
Medication: Paracetamol 0.2 0.4 1.1 -0.3 1.1 -0.7 -0.2 -0.0 -0.7
Medication: Lisinopril 0.8 1.0 2.8 -0.0 0.6 1.7 1.4 0.7 0.8
Medication: Atorvastatin 1.0 1.3 6.0 0.7 2.4 0.4 -1.0 -0.4 -0.4
Illnesses of father: High blood pressure 3.3 4.1 6.5 -0.9 -1.6 -2.2 -2.5 -2.1 2.4
Alcohol drinker status: Never 1.2 1.5 5.9 0.5 0.3 -0.8 2.4 1.2 0.7
Ever smoked 0.6 1.1 4.4 -0.3 -0.7 0.3 -2.1 -1.3 -0.0
Basal metabolic rate 0.4 2.4 4.8 0.8 2.1 -2.2 1.1 -0.8 1.6
Leg fat percentage (left) 0.9 3.3 6.9 -1.5 1.8 -2.6 1.3 -0.9 2.1
Arm fat-free mass (left) 0.4 2.1 4.5 1.0 2.1 -2.1 0.6 -0.7 1.5
Number of operations (self-reported) 1.9 2.9 4.7 1.4 -0.8 -2.2 1.2 -2.2 2.0
Average weekly beer plus cider intake 0.4 0.6 1.5 1.1 0.3 0.8 -0.0 0.7 -1.2
Irritability 0.2 0.4 1.1 0.0 -1.0 -0.2 -0.2 -0.8 0.6
Risk taking 1.2 1.8 5.1 -2.3 -1.7 0.0 1.2 1.0 0.5
Ever had prostate specific antigen (PSA) test 1.9 2.2 5.4 1.2 2.0 0.1 0.4 -1.4 2.3
Fractured/broken bones in last 5 years 0.4 0.6 2.8 0.1 -0.1 0.2 1.7 0.1 0.7
Age started oral contraceptive pill 1.0 1.2 3.7 0.3 -0.3 1.9 -1.4 -1.1 0.4
Diastolic blood pressure, automated reading 1.5 4.7 17.8 0.7 -1.0 0.3 -4.2 -2.9 0.5
Ever depressed for a whole week 0.2 0.3 0.9 -0.1 -0.1 -0.7 0.3 0.2 -0.9
Unable to work because of sickness or disability 2.5 3.3 7.0 -1.5 0.4 -2.1 1.3 -2.6 2.0
Commuting to job workplace: Cycle 0.7 0.9 1.8 -1.3 -1.2 0.2 0.1 -0.6 1.3
Myopia 0.6 0.8 2.8 -0.4 -0.2 1.7 -1.0 0.5 -0.8
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.7 1.3 -0.1 0.4 1.1 1.4 -1.6
Cholesterol lowering medication 1.3 1.9 4.4 -0.5 2.1 0.6 1.5 1.4 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 3.5 1.3 0.4 -1.9 1.7 -1.5 1.2
Pain experienced in last month 1.8 3.0 12.5 -0.3 -1.0 3.5 -1.3 1.5 -0.9
Supplements: Calcium 1.1 1.2 3.1 1.8 -0.2 -0.3 1.0 -1.0 1.5
Basal cell carcinoma (self-reported) 0.7 0.9 3.1 0.9 1.0 -1.8 0.2 -0.2 -0.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.1 0.2 -0.0 0.8 -0.6 -1.1 1.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.7 -0.0 -0.8 0.0 1.3 0.0 0.4
Heart disease (siblings) 2.7 3.3 6.9 -2.2 1.2 -0.5 -0.7 -2.5 2.6
Alcohol drinker status: Previous 0.6 0.6 2.7 -0.2 0.2 1.6 0.6 0.9 -0.0
Pack years of smoking 0.9 1.3 3.0 0.7 1.5 0.1 1.7 1.2 0.9
Impedance of whole body 0.6 2.9 8.1 -0.1 -2.9 1.9 -0.9 1.3 -1.7
Leg fat mass (left) 0.7 2.9 6.5 -0.8 2.0 -2.6 1.6 -0.7 1.7
Arm predicted mass (left) 0.5 2.7 5.7 1.3 2.3 -2.4 0.7 -0.8 1.5