Hub : Genes

PRC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1143	0.0429	3.6e-03	-0.004	NA	-0.004	NA	-0.004	7.5e-01	NA	0.85000	NA	0.7800
2	GTEx	Stomach	0.4320	0.1160	5.5e-03	-0.006	NA	-0.006	NA	-0.006	1.0e+00	NA	0.92000	NA	0.9200
3	GTEx	Testis	0.2190	0.0600	9.6e-05	0.114	NA	0.029	NA	0.001	9.3e-06	NA	0.01800	NA	0.2900
4	METSIM	Adipose	0.0422	0.0200	1.3e-02	0.030	0.004	0.000	0.008	0.006	2.3e-05	0.07000	0.35000	2.1e-02	0.0400
5	YFS	Blood	0.0358	0.0114	4.0e-05	0.020	0.009	0.009	0.012	0.010	2.6e-07	0.00056	0.00056	4.2e-05	0.0002
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.4880	0.1500	1.9e-03	0.035	0.076	0.025	NA	0.078	3.7e-02	0.00390	0.06800	NA	0.0035

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	3.3	1.2	1.8	0.7	0.2	0.3	-0.4
Bipolar Disorder or Schizophrenia	1.5	3.6	10.5	1.1	1.5	3.2	1.8	1.8	-1.2
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-0.3	-0.9	-0.6	-0.9	-0.5	0.7
Depression (Nagel 2018)	0.6	1.0	5.5	0.3	-0.2	-2.3	-0.1	-0.4	0.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.8	-1.4	-0.9	-1.0	-2.0	-1.9	0.2
Neuroticism (Nagel 2018)	0.5	1.3	3.3	0.5	-1.8	0.5	-1.2	-0.9	1.2
Schizophrenia (2018)	1.8	3.8	10.7	0.5	0.5	3.3	2.2	2.1	-1.5
Schizophrenia vs Biploar Disorder	1.7	2.2	9.4	-1.9	-3.1	-0.0	-0.7	0.0	-0.3
Worry (Nagel 2018)	1.0	2.1	7.6	1.2	-2.8	0.7	-1.7	-0.5	0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.2	0.1	-1.0	-0.5	-1.2	0.3
Alzheimer’s Disease (in father)	0.6	0.6	1.9	-0.6	0.6	-0.9	1.4	0.0	0.7
Alzheimer’s Disease (including proxy)	0.9	1.4	3.5	-1.3	0.8	-1.9	0.8	-1.2	0.7
Crohns Disease (2017)	0.3	0.7	1.7	-0.9	0.3	-1.3	-1.1	-0.2	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.5	0.0	-0.7	-0.2	0.8	-0.2
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.3	-0.7	-0.3	0.6	1.1	-0.2
Major Depression (MDD)	2.0	2.4	9.7	3.1	1.0	-0.6	-0.1	-1.5	0.9
Reaction Time	0.2	0.4	1.6	0.3	0.2	1.3	0.7	-0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.2	-1.0	-1.0	-0.9	-2.5	-1.5	-0.0
Breast Cancer	1.2	2.8	6.9	-0.8	-1.8	-1.9	-2.6	-1.5	-0.5
Ovarian Cancer	1.2	1.6	3.2	1.2	-1.4	-1.3	-1.8	-0.8	-0.6
Prostate Cancer	0.4	0.6	1.5	0.2	-0.9	1.1	1.2	-0.1	-0.3
Age at First Birth	0.8	1.2	2.2	0.4	-0.1	1.0	-1.4	1.5	-1.3
Bipolar Disorder (2011)	0.3	0.2	0.9	-0.4	1.0	0.5	-0.4	0.0	-0.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	0.2	-1.1	-0.7	-0.1	0.8	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	2.0	-0.9	-0.5	-1.4	1.1	-0.9	0.0
Crohns Disease (2012)	0.6	1.0	2.9	-1.2	0.6	-1.2	-1.7	-0.3	0.0
Mean Putamen Volume	0.7	0.8	2.9	1.7	-0.1	0.1	1.1	0.6	-0.3
Fasting Glucose	0.7	0.8	3.1	-0.4	-1.1	-1.8	-0.3	-0.2	-0.3
HbA1C	3.1	3.4	11.4	0.9	-0.4	0.2	-0.5	3.4	-2.8
HDL Cholesterol	0.6	1.0	2.7	1.6	0.4	1.6	-0.8	0.2	-0.5
LDL Cholesterol	0.7	1.2	2.0	1.4	0.2	0.7	-1.1	1.2	-1.4
Lupus	1.0	1.5	5.2	0.1	-0.4	-0.9	0.6	-1.6	2.3
Neuroticism (2016)	0.9	1.3	3.3	-1.0	-1.8	-0.7	0.5	-1.3	1.0
Primary Biliary Cirrhosis	0.7	1.0	2.3	0.9	0.6	-0.2	1.4	-1.5	0.8
Rheumatoid Arthritis	0.8	1.1	2.1	0.3	-1.0	1.0	-0.8	-1.2	1.4
Schizophrenia (2014)	1.2	2.6	5.8	0.5	0.0	2.4	0.8	1.7	-2.4
Triglycerides	0.4	0.6	1.2	-0.8	0.3	1.1	-1.1	-0.0	-0.6
Type 2 Diabetes (T2D) (2012)	2.8	3.3	10.7	-1.3	-0.3	-3.3	1.2	-0.0	2.4
Ulcerative Colitis	0.5	0.7	1.2	0.8	-1.1	0.5	0.8	1.0	-0.5
Blood Eosinophil Count	0.8	6.5	10.6	-2.5	-2.2	-3.0	2.3	-1.6	3.2
Blood Platelet Count	0.7	8.5	27.8	-1.4	0.8	3.0	5.3	0.4	3.4
Blood Red Count	0.2	1.5	5.4	0.9	0.0	-2.3	-0.3	-1.4	0.8
Blood White Count	0.0	0.2	0.7	0.0	0.2	-0.4	0.6	0.0	0.9
Heel T-Score	0.9	7.2	15.4	-3.9	0.0	-2.9	-2.1	-3.0	2.5
BMI	0.9	5.4	13.3	-1.5	3.2	-3.6	1.7	-1.1	1.4
Height	0.1	1.8	8.5	2.9	1.0	-0.3	0.5	-0.1	1.1
Waist Hip Ratio (WHR)	0.4	2.0	6.9	-0.7	-1.6	2.6	0.8	0.8	-0.7
Systolic Blood Pressure	0.8	3.8	15.2	1.8	-1.1	1.8	-3.9	-0.3	0.0
Smoking Status	0.9	2.1	3.8	-1.9	0.3	-2.0	-0.1	-1.9	1.2
Allergy or Eczema	3.4	9.0	33.8	-5.8	-3.1	-1.7	-0.5	-1.3	2.5
Cardiovascular Disease	0.3	1.0	4.0	-2.0	0.4	-1.1	-0.5	-0.6	0.3
Hypothyroidism (self reported)	0.9	2.1	4.8	-2.2	0.8	-1.6	-2.0	-0.5	0.8
Respiratory disease	1.1	2.5	7.3	0.0	0.7	-2.7	1.9	0.2	1.9
Type 2 Diabetes (T2D) (2018)	1.2	2.3	7.4	-0.3	1.3	-2.7	0.2	-1.6	1.3
Lung FEV1/FVC ratio	0.2	1.3	7.1	0.1	2.7	-0.1	0.1	0.6	-0.0
Lung FVC	0.1	0.4	1.6	0.0	-0.2	0.1	-0.8	0.6	-1.3
Neuroticism	0.4	1.1	3.2	0.1	-1.8	-0.2	-0.9	-1.1	1.1
Chronotype (morning person)	0.6	1.4	4.6	-2.2	-0.2	1.2	-1.3	-0.6	-0.0
Hair Pigment	0.1	2.9	7.8	-0.3	-0.9	2.8	-0.1	1.6	-2.5
Tanning	0.2	3.0	9.5	-2.3	-1.0	-3.1	0.4	-1.0	1.1
Hand grip strength (left)	0.5	1.4	5.4	2.3	-0.2	-0.9	-0.2	-0.1	-1.4
Number of treatments/medications taken	1.7	3.1	10.4	-1.2	1.0	-3.2	0.8	-1.4	1.7
Average weekly spirits intake	0.5	0.7	2.7	0.9	-0.2	1.6	0.5	0.5	-0.1
Sensitivity / hurt feelings	0.7	1.3	2.5	0.7	-0.7	-0.7	1.4	-1.6	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.6	0.2	-0.0	-1.1	0.9	0.6	-1.2
Hearing difficulty/problems: Yes	0.4	0.6	2.1	-0.0	1.5	-0.8	0.3	-0.2	0.8
Relative age of first facial hair	0.7	1.4	3.0	1.6	0.1	1.2	1.7	1.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	-0.6	-0.1	-0.8	-0.7	-1.3	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.7	0.2	-0.7	0.6	-0.0	1.3	-1.3
Ever had hysterectomy (womb removed)	1.3	1.5	4.1	0.7	-1.5	0.3	-2.0	-1.4	0.2
Systolic blood pressure, automated reading	1.0	3.0	12.7	1.5	-0.3	1.2	-3.6	-1.3	0.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.4	-1.1	0.9	-1.4	-1.8	-0.2	-1.1
Angina	1.5	2.0	4.2	-1.9	-0.6	0.0	-1.3	-2.0	1.5
Medication for hormone replacement therapy	0.5	0.5	1.0	1.0	0.5	-0.8	1.0	0.5	-0.3
Vitamin and mineral supplements	1.6	2.1	5.0	-2.2	0.3	0.0	-1.5	1.3	-1.9
Supplements: Zinc	0.5	0.5	1.5	0.3	-1.2	-0.7	0.9	-0.2	0.2
Medication: Co-codamol	0.8	0.9	1.7	-0.8	1.0	-1.3	1.1	0.3	-0.9
Medication: Metformin	0.8	1.1	1.8	-0.9	1.3	-1.1	0.0	-1.3	1.1
Diabetes (father)	1.1	1.3	4.7	-1.5	0.7	-2.2	0.4	-0.3	0.6
Diabetes (mother)	1.1	1.4	2.6	-0.8	-1.6	-1.0	0.4	1.5	-1.2
Severe depression (siblings)	1.3	1.4	3.2	-0.5	-1.0	-0.8	-1.6	-1.8	0.8
Pack years adult smoking proportion	0.8	1.2	2.8	0.8	1.7	-0.3	1.4	1.1	0.6
Impedance of leg (right)	0.5	2.5	4.5	-0.3	-2.1	1.6	-2.0	1.1	-1.6
Leg fat-free mass (left)	0.4	2.3	4.2	0.7	1.8	-2.0	1.7	-0.8	1.5
Trunk fat percentage	0.5	2.0	4.0	-0.5	1.6	-1.4	1.6	-0.9	2.0
Hand grip strength (right)	0.7	1.9	9.4	3.1	0.8	-1.0	-0.2	0.1	-0.7
Townsend deprivation index at recruitment	1.7	2.3	7.7	-0.2	0.2	-1.4	1.9	-0.9	2.8
Current tobacco smoking	0.7	1.1	2.5	-1.1	0.0	-1.1	-0.4	-1.6	1.1
Average weekly fortified wine intake	0.5	0.5	1.2	0.8	-1.0	0.0	1.1	-0.1	-0.6
Maternal smoking around birth	0.7	1.0	3.4	-0.2	-1.3	-1.8	0.1	0.6	0.9
Fed-up feelings	0.2	0.3	1.0	-0.4	-0.6	-0.4	0.1	-0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.6	0.7	0.1	-1.6	0.7	0.2	-0.1
Relative age voice broke	0.9	1.4	4.7	1.3	0.2	1.0	2.2	0.7	0.4
Taking other prescription medications	2.6	3.9	13.9	-1.7	1.0	-3.7	0.1	-1.8	1.6
Age when periods started (menarche)	0.5	1.2	4.7	2.2	0.8	0.5	-1.0	0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	0.8	0.3	-0.5	-0.6	-1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	8.7	-3.0	0.9	-1.9	-2.8	-1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.3	0.8	1.1	0.7	0.3	-0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.3	1.5	-1.1	-0.1	0.3	1.3	-0.1
Serious illness, injury or assault to yourself	1.8	2.2	4.2	2.0	-0.3	2.0	0.3	-1.7	1.3
High blood pressure	0.3	1.0	2.2	-1.0	0.2	-0.9	-0.7	-1.1	1.5
Hayfever, allergic rhinitis or eczema	3.4	7.4	26.0	-5.1	-3.5	-1.6	0.1	-0.9	1.7
Multivitamins +/- minerals	0.5	0.7	2.0	0.5	-0.8	-0.8	1.4	-0.3	0.6
Stomach or abdominal pain in last month	2.6	3.2	6.3	-1.1	-0.1	-2.5	0.8	-2.2	2.5
Supplements: Glucosamine	0.8	1.0	3.6	1.4	1.9	-0.6	-0.3	-0.4	0.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.4	0.1	-1.8	-0.2	-0.4	-1.9	1.4
Medication: Atenolol	0.5	0.7	1.6	-1.3	-0.1	1.1	-1.0	-0.2	0.4
Medication: Levothyroxine sodium	0.5	0.8	2.3	-0.3	1.4	-0.2	-1.5	0.5	-0.1
Sitting height	0.1	0.9	2.3	1.0	-0.7	-1.5	0.2	-0.6	1.1
Chronic bronchitis/emphysema (father)	1.0	1.1	2.7	1.1	0.9	0.0	0.3	1.7	-1.4
High blood pressure (mother)	1.0	1.5	4.5	1.2	0.1	-0.8	-2.1	-1.4	0.1
Body mass index (BMI)	0.8	3.4	7.4	-0.7	2.7	-2.5	1.3	-1.2	1.9
Impedance of leg (left)	0.6	3.1	5.4	-0.6	-2.3	1.6	-1.6	1.7	-2.2
Leg predicted mass (left)	0.4	2.2	4.0	0.7	1.7	-2.0	1.7	-0.7	1.5
Trunk fat mass	0.7	2.8	4.8	-0.2	2.1	-1.9	1.7	-0.9	2.2
Waist circumference	0.8	2.7	7.7	-0.2	2.8	-1.9	1.4	-0.8	1.5
Number of incorrect matches in round	1.3	2.2	8.3	-1.0	0.9	-0.7	2.9	0.7	1.5
Past tobacco smoking	0.3	0.5	1.3	0.5	-0.6	-0.1	0.9	1.1	-0.7
Alcohol usually taken with meals	0.2	0.4	0.8	0.3	-0.9	0.9	-0.8	-0.0	-0.3
Nervous feelings	1.1	2.0	3.0	1.1	-1.2	1.7	-0.9	1.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	0.9	0.1	-0.5	0.4	0.8	-1.4
Hearing difficulty/problems with background noise	0.7	1.1	3.9	0.7	2.0	-0.7	-0.6	-1.0	0.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.4	1.8	1.7	1.3	0.6	0.6	-0.4
Had menopause	0.6	0.8	2.5	1.4	0.0	-0.2	-1.6	-0.1	0.3
Had other major operations	1.9	2.4	5.2	-0.2	0.4	-2.3	0.8	-1.8	2.2
Forced vital capacity (FVC)	0.2	0.8	1.8	-0.1	-1.3	-1.3	-0.8	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	6.5	-2.6	1.1	-2.0	-2.2	-1.0	0.5
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.7	-1.9	-1.2	0.8	-0.2	1.2	-1.7
Qualifications: None of the above	0.8	1.7	7.0	1.5	2.6	-0.7	0.1	0.2	0.4
Financial difficulties in last 2 years	1.2	1.6	5.0	-1.2	-0.8	-2.2	1.1	1.1	0.2
Mouth/teeth dental problems	0.2	0.4	1.2	0.8	0.5	-0.1	-0.4	-1.1	0.1
Heart attack	0.5	0.6	1.3	-0.1	-0.1	0.9	-0.7	-1.2	0.9
Allergy	2.0	4.7	12.7	3.6	2.2	2.1	-1.4	0.6	-1.9
Pain all over the body in last month	1.9	2.1	3.4	-1.6	-0.5	-1.8	1.0	-1.5	1.7
Diabetes (self-reported)	1.0	1.6	4.8	-1.2	1.7	-2.2	0.0	-0.3	0.5
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	10.0	-2.8	-1.7	-3.2	-0.0	-0.3	0.1
Medication: Ramipril	0.6	0.7	1.9	-1.4	0.0	-0.9	-0.8	-0.7	0.8
Medication: Simvastatin	0.4	0.6	2.8	-1.7	0.3	0.6	0.4	0.4	0.5
Fluid intelligence score	1.0	2.1	5.5	-0.9	-0.8	-1.5	-2.4	-1.5	1.2
Illnesses of siblings	1.5	2.2	3.9	0.9	-2.0	1.5	1.3	1.6	-1.4
Neuroticism score	0.3	0.7	3.1	-0.1	-1.8	0.5	-0.4	-0.4	-0.6
Weight	0.7	3.4	6.4	0.3	2.5	-2.4	1.6	-1.0	2.1
Impedance of arm (right)	0.6	2.6	9.9	-1.2	-3.1	1.7	-0.2	0.8	-0.8
Arm fat percentage (right)	0.8	3.3	4.9	-1.6	1.7	-2.2	1.8	-1.2	2.2
Trunk fat-free mass	0.3	2.0	4.4	0.9	1.9	-2.1	0.5	-0.8	1.5
Hip circumference	1.1	4.8	12.2	0.1	3.2	-3.5	0.9	-1.5	1.8
Time employed in main current job	0.1	0.1	0.5	0.3	-0.3	0.7	0.3	0.2	-0.2
Alcohol intake versus 10 years previously	0.6	0.8	1.4	-1.1	-0.4	-1.2	0.0	-1.1	1.0
Father’s age at death	1.5	2.1	10.0	-0.5	3.2	-1.0	-0.5	-0.4	0.9
Worrier / anxious feelings	0.9	1.7	6.4	-0.8	-2.5	1.1	0.7	1.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.4	0.2	-0.1	-0.8	1.8	0.7	-0.2
Falls in the last year	1.4	1.9	5.0	-0.0	0.4	-2.2	1.8	-1.0	1.5
Hair/balding pattern: Pattern 3	0.7	1.0	3.8	-1.9	0.1	-0.5	-0.8	-0.8	0.9
Number of live births	0.3	0.5	0.8	-0.8	-0.6	-0.7	-0.9	-0.7	0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	0.3	-0.4	-1.3	-0.8	0.5	-1.3
Pulse rate	0.4	0.7	1.8	0.6	-1.2	-1.3	-0.1	0.3	0.8
Happiness	0.3	0.4	1.0	-0.4	-0.5	-1.0	0.4	-0.5	0.6
Noisy workplace	0.4	0.6	1.5	0.4	-0.8	1.2	0.0	1.0	-0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.7	9.1	-0.7	-3.0	-1.6	-0.9	-1.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.5	-1.1	0.2	-1.9	0.1	-0.9	1.5
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	-1.2	-0.6	0.5	0.8	0.9	-0.2
Asthma	1.0	1.9	5.7	-0.7	0.0	-1.4	2.4	-0.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.2	-0.5	-1.0	-0.2	1.1	-0.8
Medication: Cholesterol lowering	0.9	1.5	5.2	-0.9	-0.2	-0.4	-0.3	-1.6	2.3
Depression (self-reported)	1.1	1.4	3.9	-0.6	0.4	-2.0	1.8	0.5	-0.6
Medication: Lansoprazole	1.2	1.3	2.5	-1.3	1.6	-0.8	-0.2	-1.3	1.2
Prospective memory result	0.2	0.3	1.0	0.3	-0.3	-0.7	1.0	-0.3	0.3
Lung cancer (father)	0.7	0.8	1.9	-0.5	0.7	1.0	1.4	0.8	-0.6
Illnesses of mother	1.9	2.3	4.4	0.4	1.0	2.1	1.9	2.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	0.4	0.3	-0.8	-0.4	1.1	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.4	0.3	-0.7	1.2	0.1	0.2	0.1
Impedance of arm (left)	0.5	2.3	8.9	-0.3	-3.0	1.8	0.1	0.8	-0.9
Arm fat mass (right)	0.8	3.2	6.5	-0.8	2.1	-2.5	1.5	-1.3	2.0
Trunk predicted mass	0.4	2.1	4.7	0.9	1.9	-2.2	0.5	-0.8	1.5
Standing height	0.1	1.2	6.0	2.5	-0.0	-0.2	0.5	0.5	0.7
Length of working week for main job	0.3	0.3	0.8	0.3	-0.1	0.8	0.9	-0.3	0.4
Exposure to tobacco smoke at home	0.7	0.8	1.5	-1.0	-1.2	-1.0	-0.2	-1.1	0.1
Breastfed as a baby	2.6	3.3	11.2	-0.1	-0.8	-1.0	-1.3	-2.2	3.4
Tense / ‘highly strung’	1.0	1.7	3.4	0.7	-1.9	-1.6	-0.0	-1.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-0.6	-1.3	-0.9	1.2	-0.4	0.7
Hair/balding pattern: Pattern 4	1.7	4.2	17.7	-4.2	-2.2	-0.3	-1.4	-0.4	-0.1
Birth weight of first child	1.8	3.4	7.3	-1.9	-1.4	-0.7	2.7	2.6	-0.5
Peak expiratory flow (PEF)	0.4	0.8	2.7	0.9	0.1	-1.6	-0.3	0.7	-0.9
Pulse wave reflection index	1.1	1.4	3.6	1.5	1.9	1.5	-0.1	-0.1	0.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.7	0.1	-0.8	-1.1	1.9	-0.0	1.2
Loud music exposure frequency	0.4	0.5	1.9	0.1	-0.2	-0.5	0.1	-1.4	0.8
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.1	-0.6	-1.4	-0.3	-1.0	-1.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.3	-0.8	-0.9	0.7	-0.4	1.1	-0.5
Blood clot in the leg (DVT)	0.2	0.3	1.3	0.4	-0.1	-0.1	1.1	0.1	0.3
Medication: Paracetamol	0.2	0.3	0.9	-0.4	0.4	-0.6	-1.0	0.1	-0.6
Headache pain in last month	0.3	0.6	1.6	0.1	-1.0	-1.3	0.8	0.0	-0.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.3	1.0	0.1	0.9	0.7	1.8	-2.5
Glaucoma (self-reported)	2.2	2.6	9.2	0.4	-0.9	-0.8	-1.1	-3.0	1.9
Gout (self-reported)	0.9	1.3	4.9	-0.7	-0.7	2.2	0.0	-0.8	1.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.7	-1.9	0.8	-1.6	-1.7	-0.3	0.4
Medication: Amlodipine	1.0	1.4	5.8	0.0	-0.9	-2.4	-1.2	0.2	0.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	7.9	-0.5	-0.5	-1.3	2.8	0.8	0.8
Birth weight	0.8	1.8	4.4	1.5	-0.2	0.7	2.1	1.6	-1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.4	-1.5	-0.3	-1.5	0.8	-0.4	0.8
High blood pressure (siblings)	1.5	2.2	4.5	0.5	1.9	-0.6	-1.6	-2.1	1.3
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	0.2	-0.6	-1.0	-0.0	1.0	-0.7
Body fat percentage	0.6	2.5	4.3	-0.8	1.8	-1.8	1.6	-1.0	2.1
Leg fat percentage (right)	0.9	3.2	6.2	-1.3	1.8	-2.5	1.1	-1.1	2.3
Arm fat-free mass (right)	0.4	2.3	4.7	1.4	2.0	-2.2	0.7	-0.7	1.4
Exposure to tobacco smoke outside home	2.2	2.9	5.8	1.0	0.9	-2.4	-1.2	-2.0	2.0
Comparative body size at age 10	0.3	0.7	3.4	-1.9	0.7	-0.2	-0.3	-0.6	0.3
Number of full brothers	0.5	0.6	2.1	0.3	0.9	-1.4	0.6	-0.4	0.3
Worry too long after embarrassment	0.3	0.5	0.9	-0.4	-0.0	0.9	0.4	0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.7	0.2	-0.5	-1.1	1.5	-0.4	2.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.9	-0.4	0.0	-1.2	1.7	-0.8	1.5
Number of children fathered	1.7	1.9	5.4	0.4	-1.1	-1.5	0.4	-1.5	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.8	-0.5	0.2	-0.1	-1.7	-0.2	0.6
Age at first live birth	1.1	2.0	6.2	-1.3	-1.0	1.1	-2.5	0.4	-1.4
Pulse wave peak to peak time	0.4	0.4	1.9	0.0	0.9	-1.4	0.0	-0.1	-0.1
Health satisfaction	1.6	2.1	6.4	-1.2	-0.5	-1.6	-0.1	-1.3	2.5
Shortness of breath walking on level ground	0.4	0.5	0.9	0.3	0.7	0.5	-0.5	-1.0	0.9
Qualifications: College or University degree	0.3	0.8	2.8	-1.7	-1.3	-0.4	0.1	-0.5	-0.0
Eye problems/disorders: None of the above	0.6	0.7	2.2	-0.5	1.0	0.1	0.1	-0.6	1.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	-0.2	-0.8	0.5	-0.3	1.1	-0.4
Emphysema/chronic bronchitis	0.8	0.9	1.4	1.1	-0.8	0.1	1.2	1.2	0.7
Medication for pain relief, constipation, heartburn	0.9	1.6	4.8	0.7	-0.9	2.2	-0.0	0.8	-1.7
Neck or shoulder pain in last month	0.9	1.2	3.1	0.2	1.4	-1.8	-0.4	-1.1	0.9
Medication: Blood pressure	0.5	0.8	2.0	-1.4	-0.5	-0.0	-0.9	-0.8	1.1
Angina (self-reported)	1.4	1.9	3.7	-1.9	-0.5	0.4	-1.4	-1.8	1.3
Migraine (self-reported)	0.8	1.0	5.2	0.2	2.3	-0.5	0.4	-0.4	0.4
Medication: Ibuprofen	0.7	0.8	2.1	0.0	-0.1	-1.4	0.6	1.2	-1.0
Medication: Allopurinol	0.6	0.9	2.0	-0.8	-0.1	0.6	1.4	-0.5	1.4
Medication: Omeprazole	2.0	2.3	5.1	1.7	0.9	-2.3	1.7	-1.2	0.9
Medication: Seretide 50 evohaler	1.4	1.6	3.7	1.9	0.3	0.7	1.8	1.4	0.2
Mean time to correctly identify matches	0.3	0.6	1.1	0.4	1.0	0.8	0.9	-0.3	1.0
Heart disease (mother)	0.8	0.9	3.5	0.5	0.3	-0.9	-0.1	-1.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.4	-0.5	0.1	-0.7	-0.2	-0.2
Whole body fat mass	0.7	3.1	4.9	-0.2	2.2	-2.2	1.7	-1.0	2.1
Leg fat mass (right)	0.7	2.8	6.1	-0.7	2.0	-2.5	1.4	-0.9	1.9
Arm predicted mass (right)	0.5	2.4	5.2	1.6	2.3	-2.0	0.6	-0.5	1.3
Pulse rate, automated reading	0.3	0.9	3.4	-0.1	-1.9	-0.7	-1.1	0.5	0.1
Alcohol intake frequency.	0.5	1.1	4.3	-0.5	0.5	-0.7	2.1	-0.5	1.2
Comparative height size at age 10	0.4	2.4	9.5	3.1	0.6	-1.5	0.9	-0.5	1.0
Number of full sisters	0.5	0.6	1.6	0.5	-0.5	-0.0	-0.0	-1.2	1.3
Suffer from ‘nerves’	0.5	0.7	1.7	-0.0	-1.3	-0.6	-1.1	-0.9	-0.4
Overall health rating	1.7	3.7	11.9	-0.7	0.5	-3.5	0.9	-2.3	1.8
Chest pain or discomfort	0.7	1.0	2.3	-0.5	-0.8	-1.0	-0.8	-1.5	1.2
Had major operations	1.0	1.2	2.5	-0.7	-1.6	-0.9	0.1	-1.5	1.1
Age at last live birth	0.4	0.6	2.6	-1.6	-0.2	-0.3	-0.6	-0.4	0.6
Family relationship satisfaction	0.3	0.4	1.7	-0.6	-1.3	-0.4	0.3	0.3	-0.1
Leg pain on walking	0.7	0.9	2.8	-1.3	-0.7	-0.0	0.6	1.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	8.5	-0.3	-0.8	1.0	1.8	2.9	-1.8
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.7	0.7	-1.8	1.9	-0.3	1.3	-1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.7	-0.3	0.5	0.6	0.8	-0.7
Medication: Aspirin	2.2	2.9	7.6	-1.1	1.4	-1.1	-1.1	-2.1	2.8
Supplements: Vitamin C	2.4	2.8	7.7	1.9	0.1	-1.0	0.3	-2.1	2.8
Knee pain experienced in last month	0.7	1.1	2.6	1.1	1.2	-1.6	0.8	-0.0	0.9
Hypertension (Self-reported)	0.4	1.0	3.1	-0.7	0.7	-0.8	-0.5	-1.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	0.7	1.5	-0.9	-0.4	-0.9	-0.3
Illnesses of father: Heart disease	1.4	2.0	3.5	-0.4	-1.2	-1.8	-0.4	-1.9	1.8
Illnesses of siblings: Diabetes	2.7	3.3	10.6	-1.0	1.7	-3.3	-0.2	-2.1	1.2
Smoking status: Previous	0.5	0.8	3.3	0.0	1.8	0.2	-0.5	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	4.8	-0.0	-0.4	-2.2	0.9	1.0	-0.4
Whole body fat-free mass	0.4	2.2	4.4	1.0	2.0	-2.1	0.9	-0.8	1.5
Leg fat-free mass (right)	0.4	2.1	3.6	0.8	1.8	-1.9	1.9	-0.4	1.2
Arm fat percentage (left)	0.7	2.9	4.2	-1.3	1.7	-2.0	1.8	-1.2	2.1
Average weekly red wine intake	0.3	0.4	1.0	1.0	-1.0	-0.0	-0.1	-0.0	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.3	0.0	-0.2	0.2	-0.9	1.0
Mood swings	0.1	0.1	0.3	0.3	0.0	0.0	-0.1	-0.4	0.5
Loneliness, isolation	0.5	0.7	3.5	-0.5	-0.4	-0.2	1.9	0.2	0.3
Long-standing illness, disability or infirmity	2.8	4.2	8.1	-0.7	1.7	-2.5	-0.6	-2.7	2.9
Ever had bowel cancer screening	3.5	4.1	10.1	1.3	-0.5	-1.8	-2.0	-3.2	2.4
Diabetes diagnosed by doctor	1.3	2.1	7.1	-1.0	1.4	-2.7	-0.9	-1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	-1.2	-0.4	-1.4	0.1	-0.5	0.8
Friendships satisfaction	1.1	1.4	4.5	-0.8	-0.9	-1.4	2.1	0.5	0.0
Qualifications: nursing, teaching	0.3	0.5	2.3	-0.4	0.1	-1.5	-0.5	-0.2	-0.2
Commuting to job workplace: Walk	1.5	1.7	4.2	-0.1	0.6	-2.0	1.5	-0.1	1.8
Eye problems/disorders: Cataract	1.3	1.5	3.3	0.4	-1.2	-1.8	1.6	1.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.4	0.6	-0.3	-1.2	0.2	-0.2	0.6
Medication for cholesterol	0.6	1.0	5.3	-0.1	-2.3	0.1	-0.5	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.0	0.8	-0.6	0.5	0.5	-0.8
Back pain experienced in last month	0.4	0.6	2.7	-0.3	0.5	-1.6	0.3	-0.3	-0.4
Mineral and other dietary supplements	2.4	3.2	6.3	-2.4	-1.0	1.6	0.4	2.5	-1.9
Breast cancer (self-reported)	0.3	0.3	0.5	0.6	-0.7	0.6	0.6	0.6	-0.2
Asthma (self-reported)	1.0	1.9	5.0	-0.9	0.2	-1.2	2.0	-0.5	2.2
Osteoporosis (self-reported)	2.5	3.1	12.6	-0.6	-1.6	-0.6	3.5	-0.4	1.6
Osteoarthritis (self-reported)	0.8	1.0	1.9	0.4	1.1	-1.2	-0.1	-1.2	1.4
Medication: Aspirin	1.9	2.5	4.5	-1.0	1.8	-1.1	-1.1	-1.9	2.1
Medication: Gliclazide	0.4	0.4	2.0	-1.4	-0.2	-0.7	0.0	0.4	-0.1
Illnesses of father: None of the above (group 1)	2.3	2.9	13.8	0.9	0.1	3.7	0.1	0.3	-1.6
Smoking status: Current	0.8	1.3	2.5	-1.3	-0.1	-1.6	-0.1	-1.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	0.6	-1.4	-1.1	0.3	-0.7	0.3
Whole body water mass	0.4	2.4	4.8	1.0	2.0	-2.2	1.1	-0.8	1.6
Leg predicted mass (right)	0.4	2.2	3.9	0.7	1.9	-2.0	1.9	-0.4	1.2
Arm fat mass (left)	0.8	3.2	5.8	-0.5	2.4	-2.4	1.6	-1.0	1.9
Number of self-reported non-cancer illnesses	2.9	5.0	10.6	-1.8	1.6	-3.2	2.3	-1.7	2.4
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.1	-0.2	0.7	0.7	-0.1	0.5
Miserableness	0.2	0.3	1.2	0.1	-1.1	-0.6	0.5	-0.3	-0.1
Guilty feelings	0.4	0.5	1.1	0.7	-1.0	1.1	0.3	-0.7	0.1
Wears glasses or contact lenses	0.9	1.0	3.2	0.5	0.6	-1.4	0.7	1.8	0.4
Ever taken oral contraceptive pill	0.9	1.0	4.3	-0.6	-2.1	0.5	0.0	-0.5	0.8
Hearing aid user	2.0	2.3	4.7	2.2	1.2	1.5	0.4	1.9	-1.3
Mother’s age at death	0.5	0.6	2.6	-0.1	-0.8	-1.6	-0.4	-0.1	0.1
Financial situation satisfaction	0.6	0.7	1.7	-0.1	-0.4	-1.0	0.8	-1.1	1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.5	-0.3	-0.1	-1.0	-0.3	0.6
Commuting to job workplace: Public transport	1.6	1.9	4.7	-0.1	1.0	-2.2	1.3	-1.4	1.4
Eye problems/disorders: Glaucoma	1.3	1.6	5.6	0.3	-0.8	-0.4	-0.8	-2.4	1.5
Medication: Blood pressure	0.5	1.0	4.9	0.3	2.2	-0.4	-0.6	-0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.0	-0.3	1.7	-1.4	1.0	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.1	2.0	-0.2	-1.1	-0.6	-1.7	1.8
High cholesterol (Self-reported)	0.2	0.4	1.4	-0.3	0.5	1.2	0.8	-0.3	0.4
Medication: Bendroflumethiazide	0.4	0.6	1.2	0.2	0.9	-1.1	0.6	0.9	-0.4
Medication: Paracetamol	0.2	0.4	1.1	-0.3	1.1	-0.7	-0.2	-0.0	-0.7
Medication: Lisinopril	0.8	1.0	2.8	-0.0	0.6	1.7	1.4	0.7	0.8
Medication: Atorvastatin	1.0	1.3	6.0	0.7	2.4	0.4	-1.0	-0.4	-0.4
Illnesses of father: High blood pressure	3.3	4.1	6.5	-0.9	-1.6	-2.2	-2.5	-2.1	2.4
Alcohol drinker status: Never	1.2	1.5	5.9	0.5	0.3	-0.8	2.4	1.2	0.7
Ever smoked	0.6	1.1	4.4	-0.3	-0.7	0.3	-2.1	-1.3	-0.0
Basal metabolic rate	0.4	2.4	4.8	0.8	2.1	-2.2	1.1	-0.8	1.6
Leg fat percentage (left)	0.9	3.3	6.9	-1.5	1.8	-2.6	1.3	-0.9	2.1
Arm fat-free mass (left)	0.4	2.1	4.5	1.0	2.1	-2.1	0.6	-0.7	1.5
Number of operations (self-reported)	1.9	2.9	4.7	1.4	-0.8	-2.2	1.2	-2.2	2.0
Average weekly beer plus cider intake	0.4	0.6	1.5	1.1	0.3	0.8	-0.0	0.7	-1.2
Irritability	0.2	0.4	1.1	0.0	-1.0	-0.2	-0.2	-0.8	0.6
Risk taking	1.2	1.8	5.1	-2.3	-1.7	0.0	1.2	1.0	0.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.4	1.2	2.0	0.1	0.4	-1.4	2.3
Fractured/broken bones in last 5 years	0.4	0.6	2.8	0.1	-0.1	0.2	1.7	0.1	0.7
Age started oral contraceptive pill	1.0	1.2	3.7	0.3	-0.3	1.9	-1.4	-1.1	0.4
Diastolic blood pressure, automated reading	1.5	4.7	17.8	0.7	-1.0	0.3	-4.2	-2.9	0.5
Ever depressed for a whole week	0.2	0.3	0.9	-0.1	-0.1	-0.7	0.3	0.2	-0.9
Unable to work because of sickness or disability	2.5	3.3	7.0	-1.5	0.4	-2.1	1.3	-2.6	2.0
Commuting to job workplace: Cycle	0.7	0.9	1.8	-1.3	-1.2	0.2	0.1	-0.6	1.3
Myopia	0.6	0.8	2.8	-0.4	-0.2	1.7	-1.0	0.5	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.7	1.3	-0.1	0.4	1.1	1.4	-1.6
Cholesterol lowering medication	1.3	1.9	4.4	-0.5	2.1	0.6	1.5	1.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.5	1.3	0.4	-1.9	1.7	-1.5	1.2
Pain experienced in last month	1.8	3.0	12.5	-0.3	-1.0	3.5	-1.3	1.5	-0.9
Supplements: Calcium	1.1	1.2	3.1	1.8	-0.2	-0.3	1.0	-1.0	1.5
Basal cell carcinoma (self-reported)	0.7	0.9	3.1	0.9	1.0	-1.8	0.2	-0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.2	-0.0	0.8	-0.6	-1.1	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.7	-0.0	-0.8	0.0	1.3	0.0	0.4
Heart disease (siblings)	2.7	3.3	6.9	-2.2	1.2	-0.5	-0.7	-2.5	2.6
Alcohol drinker status: Previous	0.6	0.6	2.7	-0.2	0.2	1.6	0.6	0.9	-0.0
Pack years of smoking	0.9	1.3	3.0	0.7	1.5	0.1	1.7	1.2	0.9
Impedance of whole body	0.6	2.9	8.1	-0.1	-2.9	1.9	-0.9	1.3	-1.7
Leg fat mass (left)	0.7	2.9	6.5	-0.8	2.0	-2.6	1.6	-0.7	1.7
Arm predicted mass (left)	0.5	2.7	5.7	1.3	2.3	-2.4	0.7	-0.8	1.5