Hub : Genes

SEMA4B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0400	6.1e-05	0.013	0.037	0.036	0.038	0.023	8.5e-03	2.5e-05	2.6e-05	1.6e-05	8.0e-04
2	GTEx	Adipose Visceral Omentum	0.1270	0.0510	2.6e-03	-0.004	NA	0.047	NA	0.033	5.8e-01	NA	1.7e-03	NA	8.2e-03
3	GTEx	Artery Aorta	0.1240	0.0510	3.8e-03	0.092	NA	0.046	NA	0.070	9.2e-06	NA	1.5e-03	NA	1.1e-04
4	GTEx	Esophagus Mucosa	0.1580	0.0520	6.9e-04	0.104	NA	0.073	NA	0.094	1.9e-07	NA	1.4e-05	NA	7.2e-07
5	GTEx	Muscle Skeletal	0.1038	0.0365	7.2e-05	0.041	NA	0.045	NA	0.051	6.6e-05	NA	2.8e-05	NA	8.6e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1220	0.0540	9.3e-03	0.067	NA	0.107	NA	0.114	1.6e-04	NA	1.8e-06	NA	7.9e-07
7	GTEx	Skin Sun Exposed Lower leg	0.1590	0.0540	1.2e-04	0.046	NA	0.085	NA	0.108	1.0e-04	NA	1.5e-07	NA	3.1e-09
8	GTEx	Spleen	0.2970	0.0960	9.9e-04	0.025	NA	0.004	NA	0.031	7.4e-02	NA	2.5e-01	NA	5.6e-02
9	GTEx	Whole Blood	0.1290	0.0490	9.0e-04	0.021	NA	0.027	NA	0.045	4.2e-03	NA	1.4e-03	NA	4.9e-05
10	YFS	Blood	0.0618	0.0170	2.3e-10	0.002	0.029	0.023	0.028	0.015	6.1e-02	8.7e-10	3.5e-08	1.0e-09	6.6e-06
11	TCGA	Lung Squamous Cell Carcinoma	0.0646	0.0312	1.8e-04	0.012	0.030	0.017	NA	0.022	1.5e-02	2.4e-04	4.6e-03	NA	1.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	5.4	-0.5	-1.7	-2.3	0.2	0.5	0.2	-0.0	-0.5	-2.0	-0.7	0.1
Bipolar Disorder or Schizophrenia	1.1	2.6	7.9	-0.1	0.9	-2.4	1.7	1.7	1.4	1.8	1.2	-2.8	-1.1	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	6.0	-1.4	0.4	-0.2	0.1	0.4	0.6	1.6	0.4	-0.9	-2.5	-0.5
Depression (Nagel 2018)	0.5	0.8	1.8	0.0	-0.2	0.2	0.9	0.7	1.3	1.3	1.3	-0.3	-1.3	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.1	0.2	-1.8	0.7	-1.4	-1.8	-0.9	-0.6	-1.7	0.8	0.8	-1.3
Neuroticism (Nagel 2018)	0.5	1.2	5.1	-2.3	-0.5	-0.5	-0.5	-0.6	0.1	0.8	-0.7	-0.6	-1.9	-1.5
Schizophrenia (2018)	1.4	2.9	6.0	0.2	2.4	-1.2	2.0	1.7	1.6	2.3	1.9	-1.9	-0.9	1.0
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	-1.2	-0.3	0.7	1.2	-0.6	0.7	0.3	-0.4	0.8	0.9	0.2
Worry (Nagel 2018)	1.0	2.0	6.6	-1.9	-1.1	-1.2	-1.2	-1.4	-0.7	-0.5	-1.8	-0.1	-1.5	-2.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.5	-0.4	0.8	0.4	1.6	0.6	1.3	0.4	1.0	-0.4	-0.7	1.6
Alzheimer’s Disease (in father)	0.7	0.8	1.7	-1.2	0.2	1.2	-0.0	-0.9	0.1	0.8	-1.0	1.1	1.3	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.7	-0.5	0.9	0.7	0.7	0.4	0.6	0.5	0.4	-0.2	-0.1	1.3
Crohns Disease (2017)	0.3	0.6	1.9	-0.4	-1.3	-0.6	-0.5	-0.6	-0.3	-0.5	-1.4	-0.0	0.8	-1.2
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	-0.5	-1.1	-0.5	0.2	0.4	0.9	0.6	-0.4	0.0	1.5	-0.3
Ulcerative Colitis (UC)	0.6	1.1	2.4	-0.7	-0.1	-0.5	0.8	1.6	1.5	1.3	0.9	-0.2	1.2	1.4
Major Depression (MDD)	0.3	0.4	1.7	-0.7	-1.3	-0.3	-0.5	0.4	0.7	0.4	0.3	-0.6	0.8	-0.2
Reaction Time	0.3	0.6	1.9	0.4	0.0	-1.2	-0.4	0.6	-0.1	0.6	0.3	-1.4	-1.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.9	0.6	-2.2	0.1	-1.0	-1.6	-0.8	-0.7	-1.5	0.5	1.2	-0.8
Breast Cancer	0.7	1.7	7.4	-0.2	-2.0	-0.1	0.1	-1.9	0.4	0.9	-1.1	0.2	-1.1	-2.7
Ovarian Cancer	0.5	0.6	1.7	-0.7	-1.1	-0.1	1.2	0.0	1.3	0.6	-0.4	0.1	1.0	-0.3
Prostate Cancer	1.1	1.5	5.1	1.0	-2.0	1.1	0.2	-0.7	-1.0	-1.2	0.1	1.6	2.2	0.6
Age at First Birth	1.4	2.1	6.6	-1.2	-1.3	-2.6	-2.3	-0.6	-1.5	-1.4	-1.2	-1.2	-0.6	-0.3
Bipolar Disorder (2011)	0.3	0.3	2.4	0.4	-0.5	0.0	-0.0	0.0	0.4	0.7	-0.1	-0.2	-1.6	-0.3
Body Mass Index (BMI) (2010)	2.7	3.7	10.0	1.4	3.2	0.5	1.8	1.8	2.0	2.7	2.4	-0.6	-1.6	1.6
Coronary Artery Disease (CAD)	1.0	1.2	2.4	1.6	0.8	1.3	1.1	0.4	1.3	1.4	0.9	0.8	-1.2	-0.1
Crohns Disease (2012)	0.7	1.1	3.3	-1.1	-1.8	-0.7	-1.0	-0.7	-0.3	-0.5	-1.6	-0.1	0.5	-1.5
Mean Putamen Volume	1.3	1.5	4.0	-1.0	-1.4	0.5	-0.7	-1.5	-0.6	-1.0	-2.0	0.7	1.6	-1.6
Fasting Glucose	0.9	1.1	3.4	-0.3	0.1	1.8	1.4	-0.4	1.4	0.8	0.0	1.5	0.4	1.1
HbA1C	0.5	0.5	1.8	-0.4	-0.7	0.1	0.0	1.0	0.5	1.3	0.7	-0.0	-1.2	0.2
HDL Cholesterol	0.4	0.7	2.8	-0.2	-0.5	0.1	1.7	0.2	1.5	0.6	0.8	-0.4	0.3	1.1
LDL Cholesterol	0.3	0.5	2.2	-0.9	-1.5	-0.2	-0.4	-0.1	-0.1	-0.6	-0.5	0.1	1.1	0.3
Lupus	0.7	1.0	3.1	-0.3	-0.7	-1.8	-1.3	-0.3	-1.7	-0.9	-0.9	-1.0	0.4	-0.7
Neuroticism (2016)	0.3	0.5	1.3	0.9	-0.5	0.8	-0.2	-0.6	-0.2	-0.1	-0.6	0.9	-1.0	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.0	-0.2	0.8	0.2	1.4	0.5	0.8	0.7	0.7	0.1	0.1	1.3
Rheumatoid Arthritis	0.7	0.9	4.1	-0.8	2.0	0.1	0.4	1.5	0.4	0.9	1.0	-0.6	-0.3	0.8
Schizophrenia (2014)	0.4	0.9	2.8	-0.5	0.5	-1.5	0.9	1.0	0.5	1.0	0.9	-1.7	-0.3	0.3
Triglycerides	0.6	1.0	5.8	-0.3	-0.9	1.0	0.0	-0.7	-0.8	-0.4	-0.7	1.1	2.4	0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.9	-0.2	0.7	-0.7	-1.4	0.2	-1.3	-0.5	-0.4	-0.0	-0.3	-0.9
Ulcerative Colitis	0.7	1.0	1.9	-0.9	-0.3	-0.6	0.8	1.4	1.4	1.3	0.8	-0.4	1.0	1.2
Blood Eosinophil Count	0.2	1.6	5.4	2.3	1.4	1.4	0.2	1.2	0.1	-0.3	1.1	-0.5	-2.0	0.8
Blood Platelet Count	0.3	3.0	8.7	2.5	-0.1	2.9	1.7	-0.1	1.7	0.7	1.1	1.4	1.8	2.3
Blood Red Count	0.7	6.3	15.4	-2.9	-2.3	-0.8	-2.3	-2.9	-2.2	-2.3	-3.9	1.2	0.5	-3.7
Blood White Count	0.2	1.8	4.8	-1.1	0.7	2.2	1.5	0.3	1.5	1.1	0.7	0.6	1.7	2.1
Heel T-Score	3.7	29.7	84.1	2.8	-9.2	2.7	-3.5	-7.1	-4.8	-6.5	-5.1	4.5	6.5	-3.1
BMI	0.6	3.7	9.3	1.7	2.1	-0.6	0.5	2.8	0.5	0.7	3.1	-2.1	-1.8	2.6
Height	0.2	4.7	16.5	-4.1	2.7	0.3	-1.7	-1.6	-1.4	-1.5	-2.3	1.3	2.5	-2.3
Waist Hip Ratio (WHR)	0.1	0.6	2.4	-0.7	0.4	-0.0	0.7	-0.9	0.3	0.4	-1.0	0.5	-1.6	-1.0
Systolic Blood Pressure	1.9	9.6	21.8	-4.7	-1.9	-0.8	-2.6	-3.1	-3.2	-4.0	-4.1	1.5	3.0	-3.0
Smoking Status	0.7	1.7	5.7	0.1	0.5	-0.0	0.5	2.4	0.6	1.3	1.9	-0.9	-1.2	2.2
Allergy or Eczema	1.8	4.7	26.6	5.2	1.1	-0.7	-2.1	-0.3	-2.4	-1.8	-0.1	-0.4	-3.0	-1.0
Cardiovascular Disease	0.6	2.0	6.8	-0.8	0.1	0.2	-2.2	-1.1	-2.6	-2.6	-1.1	0.4	0.2	-0.9
Hypothyroidism (self reported)	0.2	0.4	1.1	0.9	0.2	1.1	0.7	0.1	-0.2	-0.6	0.0	0.9	0.6	0.5
Respiratory disease	0.7	1.5	2.9	0.7	1.6	-0.4	1.7	1.4	1.0	1.7	1.2	-0.6	-0.5	1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.2	-1.5	-0.5	-0.1	-0.1	0.1	-0.0	-1.0	-0.1	-0.1	-0.3	0.9
Lung FEV1/FVC ratio	0.4	1.8	4.2	-1.0	-1.4	1.9	0.7	-1.2	1.3	1.7	-0.5	2.1	0.8	0.9
Lung FVC	1.0	5.0	10.0	-1.3	-1.9	1.6	-2.2	-3.2	-2.4	-1.9	-2.9	1.6	2.2	-2.6
Neuroticism	0.5	1.1	4.8	-1.2	-0.1	0.0	-0.5	-1.2	-0.2	0.4	-1.2	-0.0	-1.6	-2.2
Chronotype (morning person)	0.7	1.6	4.2	2.1	-0.1	0.3	-1.1	-0.7	-1.8	-2.0	-0.5	1.4	1.3	-0.4
Hair Pigment	0.1	3.9	9.3	2.7	0.4	-2.9	1.3	2.0	0.5	1.6	1.0	-3.0	-2.9	-0.3
Tanning	0.1	1.2	4.1	1.8	1.2	0.3	-2.0	0.3	-1.1	-0.6	0.2	-1.0	-0.9	-0.9
Hand grip strength (left)	0.7	1.7	7.3	-1.3	-1.1	1.0	-0.6	-1.3	-0.4	-0.5	-1.5	1.2	2.7	-1.1
Number of treatments/medications taken	0.5	0.8	3.3	-0.8	1.8	0.5	1.0	0.9	0.8	0.7	0.5	-0.1	-0.7	1.2
Average weekly spirits intake	1.3	1.6	5.3	-0.9	-0.1	0.3	2.0	0.8	2.3	2.1	1.2	-0.2	0.1	1.0
Sensitivity / hurt feelings	0.5	0.9	2.1	-1.0	-0.3	1.4	0.4	-1.4	0.5	-0.1	-1.0	1.3	0.2	-1.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.4	-0.5	0.5	-0.3	0.4	0.2	0.4	0.9	0.5	-0.1	-1.6	-0.6
Hearing difficulty/problems: Yes	0.4	0.5	2.5	-1.6	0.4	0.2	-0.2	0.5	0.3	1.2	0.3	-0.2	-1.1	0.2
Relative age of first facial hair	0.5	1.0	3.5	-0.4	-1.3	-0.2	-0.5	-1.4	-0.5	-1.3	-1.3	0.4	1.9	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	3.6	-0.4	0.6	0.1	0.9	-0.0	-0.7	-0.9	0.3	-0.1	1.9	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	3.4	-0.4	1.1	0.1	-0.7	0.8	-0.4	0.3	0.9	-0.7	-1.8	-0.8
Ever had hysterectomy (womb removed)	0.3	0.3	2.8	-1.7	0.3	0.2	-0.1	-0.4	0.1	-0.2	0.2	0.1	-0.1	-0.2
Systolic blood pressure, automated reading	0.8	2.3	10.8	-3.3	-0.7	-0.3	-0.6	-1.3	-0.9	-1.1	-2.3	1.2	1.1	-1.2
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	6.2	-0.1	-1.4	2.5	-0.2	-2.4	-0.3	-1.2	-1.9	2.2	1.4	-2.0
Angina	0.4	0.5	1.7	0.5	0.3	0.6	-0.1	-1.3	-0.2	-0.7	-1.2	0.8	0.4	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.6	0.9	0.6	0.3	0.1	-0.0	0.6	0.2	0.3	0.4	-0.1
Vitamin and mineral supplements	0.6	0.8	2.8	-0.2	-0.7	-1.0	-1.3	-0.1	-1.3	-1.7	-0.8	-0.5	-0.5	-0.5
Supplements: Zinc	1.0	1.1	2.9	-0.8	1.1	-0.2	0.5	0.9	1.2	1.7	1.0	-1.2	-1.4	0.2
Medication: Co-codamol	0.5	0.6	1.7	-0.9	1.3	-0.3	-1.3	0.1	-0.6	-0.4	0.4	-0.9	-0.8	-0.3
Medication: Metformin	1.2	1.7	4.4	-2.1	-0.4	-0.8	-1.8	-0.8	-1.5	-1.9	-1.4	-0.6	-1.0	-0.8
Diabetes (father)	1.0	1.3	3.8	0.1	1.3	-1.9	-0.1	1.1	-0.5	-0.1	0.6	-1.3	-2.0	1.0
Diabetes (mother)	0.7	0.9	4.5	-1.1	1.5	-1.0	0.2	0.6	0.6	0.5	0.0	-0.5	-2.1	-0.4
Severe depression (siblings)	0.8	0.9	2.1	-0.3	0.9	-1.2	-1.3	0.4	-1.2	-1.4	-0.5	-0.6	-0.8	-0.9
Pack years adult smoking proportion	0.9	1.3	4.2	0.1	2.0	0.9	1.0	1.2	1.6	1.5	1.1	-0.7	0.3	0.7
Impedance of leg (right)	0.2	1.1	3.9	-0.2	-0.3	1.3	0.5	-1.5	0.4	0.5	-1.1	2.0	1.0	-1.2
Leg fat-free mass (left)	0.3	1.6	6.3	-0.7	2.5	-0.8	-1.1	1.5	-0.9	-0.9	1.2	-1.7	-0.8	0.7
Trunk fat percentage	0.6	2.5	7.3	1.1	1.6	0.8	1.4	2.1	1.1	1.2	2.4	-0.9	-0.7	2.7
Hand grip strength (right)	0.9	2.5	9.8	-1.8	-1.7	0.2	-1.0	-1.6	-0.2	-0.4	-2.1	1.1	3.1	-1.4
Townsend deprivation index at recruitment	0.6	0.8	2.1	0.6	1.5	-0.7	-1.2	0.8	-1.2	-1.0	0.9	-0.5	-0.9	0.1
Current tobacco smoking	0.8	1.2	4.0	0.7	0.8	0.5	0.8	2.0	1.0	1.1	1.6	-0.8	-0.7	1.3
Average weekly fortified wine intake	0.3	0.4	0.9	-0.8	-0.5	-0.4	-0.9	-0.6	-0.5	-0.7	-0.3	0.8	-0.4	-0.3
Maternal smoking around birth	0.1	0.2	0.5	0.4	0.3	0.7	0.6	-0.0	0.6	0.5	0.3	-0.1	-0.4	0.7
Fed-up feelings	0.4	0.8	4.4	0.1	0.3	0.2	-0.4	1.0	-0.2	0.4	1.4	-0.8	-2.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	1.0	0.1	0.7	0.9	-0.3	0.4	-0.1	0.4	0.4	0.1	-0.2
Relative age voice broke	1.6	2.5	5.8	-0.3	-0.9	-0.1	-2.0	-1.9	-1.7	-2.0	-2.4	1.1	1.5	-1.5
Taking other prescription medications	0.6	1.0	3.5	0.8	1.9	1.3	1.1	0.8	0.8	0.0	1.1	0.3	-0.2	1.1
Age when periods started (menarche)	0.9	2.2	7.4	-0.2	-0.9	2.0	0.7	-1.8	1.3	0.9	-1.0	2.2	2.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.7	-1.0	1.6	1.3	0.6	-0.1	0.4	1.5	0.3	0.7	-1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	8.2	2.7	-2.6	1.5	-1.7	-1.9	-2.9	-2.3	-1.0	1.6	2.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.4	0.5	1.1	-0.3	-0.7	-0.0	-0.0	0.7	-0.1	0.3	-1.6	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.7	0.4	-0.4	0.2	0.9	0.2	0.6	1.1	-0.1	-0.6	0.5
Serious illness, injury or assault to yourself	3.0	3.7	11.9	0.3	-0.6	1.8	3.4	0.4	2.9	2.2	1.4	0.8	1.9	2.4
High blood pressure	0.9	2.5	4.6	-1.4	-0.8	1.2	-0.7	-2.1	-1.8	-2.1	-2.1	1.8	1.6	-0.7
Hayfever, allergic rhinitis or eczema	2.2	4.8	24.4	4.9	1.3	-0.3	-2.3	-0.4	-2.6	-1.7	-0.1	-0.1	-3.0	-1.5
Multivitamins +/- minerals	0.4	0.5	1.4	-0.1	0.4	0.8	1.2	0.3	1.1	0.7	0.6	0.2	0.6	0.6
Stomach or abdominal pain in last month	1.6	2.0	3.9	0.4	1.9	0.1	1.6	1.4	1.9	1.5	2.0	-1.0	-1.1	1.1
Supplements: Glucosamine	0.5	0.7	2.8	0.3	-0.6	0.5	1.6	0.1	0.8	-0.1	0.2	0.4	1.7	0.8
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	6.6	-1.8	-1.5	-1.4	-0.7	-2.0	-0.6	-1.2	-2.6	0.0	1.0	-1.9
Medication: Atenolol	0.4	0.5	1.1	1.1	0.9	0.9	0.0	-0.2	-0.8	-1.0	0.4	0.6	0.1	0.5
Medication: Levothyroxine sodium	0.7	1.1	3.5	-0.0	-0.3	0.6	1.9	1.0	1.0	0.5	0.9	0.1	1.4	1.8
Sitting height	0.8	6.0	14.8	-1.4	1.1	-0.8	-3.3	-2.6	-3.0	-3.0	-3.2	1.1	0.7	-3.9
Chronic bronchitis/emphysema (father)	0.8	0.9	4.4	-2.1	-0.1	-1.4	-0.7	-0.4	-0.4	-0.9	-0.9	-0.6	-0.3	-0.9
High blood pressure (mother)	1.2	1.6	7.4	-2.7	0.6	-0.1	0.0	-1.6	0.0	-0.5	-1.5	0.8	0.7	-1.9
Body mass index (BMI)	0.4	1.9	8.3	0.9	0.4	-0.2	0.7	2.1	0.5	0.4	2.0	-1.4	-0.6	2.9
Impedance of leg (left)	0.2	1.0	3.3	-0.1	-0.3	1.1	0.8	-1.3	0.6	0.9	-1.0	1.8	0.9	-1.2
Leg predicted mass (left)	0.3	1.6	6.2	-0.7	2.5	-0.9	-1.1	1.5	-1.0	-1.0	1.1	-1.7	-0.7	0.6
Trunk fat mass	0.5	2.0	5.6	0.5	2.0	0.5	1.1	2.0	0.8	0.8	2.1	-0.9	-0.4	2.4
Waist circumference	0.6	2.1	5.4	-0.0	2.0	-0.4	0.9	2.1	0.8	0.8	2.0	-1.3	-1.2	2.3
Number of incorrect matches in round	2.4	4.0	11.9	0.2	2.6	1.6	2.1	1.0	2.8	3.5	1.5	-0.2	-2.6	-0.3
Past tobacco smoking	0.5	0.9	3.8	0.9	0.1	0.5	0.0	-1.6	0.2	-0.2	-1.4	0.8	-0.0	-1.9
Alcohol usually taken with meals	2.1	3.4	7.8	-1.7	-1.5	1.7	-0.8	-2.8	-0.7	-1.1	-2.0	2.6	2.4	-1.7
Nervous feelings	2.1	3.9	12.1	-1.6	-0.6	-1.8	-2.8	-1.6	-2.1	-1.5	-2.1	0.1	-1.9	-3.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	5.4	-0.7	0.5	-1.6	-0.6	0.8	-0.5	-0.9	0.3	-1.6	-2.3	-0.9
Hearing difficulty/problems with background noise	1.2	2.0	5.9	-2.1	0.3	-0.9	-2.4	-0.6	-1.8	-0.4	-1.0	-0.4	-1.2	-2.0
Hair/balding pattern: Pattern 2	0.7	0.9	3.3	-0.5	0.8	-1.8	-0.6	-0.6	-0.1	-0.3	-1.0	-0.9	-0.6	-1.5
Had menopause	0.9	1.1	2.9	0.7	-1.2	-1.6	-1.4	0.7	-1.2	-0.2	0.2	-1.7	-0.7	-0.6
Had other major operations	1.6	1.9	7.8	-0.7	0.3	1.3	2.8	-0.3	2.3	1.9	0.5	-0.2	-0.2	1.2
Forced vital capacity (FVC)	0.5	2.1	6.3	-1.7	1.8	0.3	-1.7	-1.5	-1.2	-0.5	-1.8	1.0	-0.1	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	8.3	2.0	-2.9	1.3	-1.2	-2.3	-2.4	-2.2	-1.3	1.5	2.8	0.2
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.3	1.4	1.9	0.8	1.1	1.5	1.0	1.0	2.1	-0.6	-1.3	2.0
Qualifications: None of the above	0.2	0.4	1.0	-0.3	1.0	-0.7	0.5	0.8	-0.1	-0.4	0.2	-0.8	0.1	0.9
Financial difficulties in last 2 years	0.5	0.6	1.8	1.2	0.8	1.3	-0.1	0.4	-0.7	0.2	1.0	0.3	-0.8	0.8
Mouth/teeth dental problems	1.3	2.0	5.1	-2.3	-0.3	1.2	1.8	-0.1	2.0	2.0	0.1	1.2	1.3	1.2
Heart attack	0.6	0.8	2.2	0.7	1.3	-0.1	0.6	1.5	0.9	1.1	0.7	-0.6	-0.8	-0.1
Allergy	1.4	3.3	16.8	-4.1	-1.8	1.1	1.3	-0.4	1.8	0.9	-0.4	0.8	2.9	0.7
Pain all over the body in last month	1.3	1.4	3.1	0.9	0.3	-1.8	0.9	1.3	1.5	1.1	0.4	-1.5	-1.1	1.4
Diabetes (self-reported)	0.5	0.7	3.6	-1.9	0.7	1.1	0.5	-0.4	0.2	-0.6	-0.3	0.7	0.2	1.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	14.9	3.9	0.7	-0.3	-1.1	0.1	-1.6	-1.5	0.6	-0.7	-0.8	0.0
Medication: Ramipril	1.0	1.3	3.5	-0.5	-0.9	1.9	1.8	-0.6	1.4	0.2	-0.2	0.8	1.4	1.2
Medication: Simvastatin	0.3	0.5	1.4	-0.3	0.9	-0.1	0.1	0.9	0.2	-0.0	0.7	-0.8	-0.9	1.2
Fluid intelligence score	0.8	1.7	5.4	-0.5	-2.3	1.2	-1.5	-1.7	-1.2	-0.8	-1.4	1.0	1.1	-1.0
Illnesses of siblings	0.7	0.9	2.7	0.2	0.5	-1.5	-0.1	1.1	0.4	1.1	0.7	-1.3	-1.6	-0.4
Neuroticism score	0.6	1.2	4.7	-1.4	0.0	-0.1	-0.7	-0.9	-0.4	0.0	-0.9	-0.3	-2.0	-2.2
Weight	0.2	1.2	3.6	-0.5	1.9	-0.4	0.1	1.7	0.1	0.0	1.4	-1.3	-0.4	1.7
Impedance of arm (right)	0.1	0.7	3.3	1.0	1.8	0.9	0.7	0.3	0.6	0.4	0.7	0.6	-0.7	0.1
Arm fat percentage (right)	1.0	3.8	12.6	1.9	1.5	0.4	1.6	2.6	1.2	1.1	2.8	-1.2	-1.1	3.5
Trunk fat-free mass	0.2	1.1	4.6	-1.9	2.2	-0.6	-1.0	0.3	-0.8	-0.8	-0.2	-0.5	0.2	-0.6
Hip circumference	0.6	2.6	7.8	-0.8	2.1	-0.8	0.3	2.8	0.6	0.5	2.3	-1.8	-0.5	2.4
Time employed in main current job	0.5	0.6	2.0	-1.4	-0.7	-0.4	0.3	-1.0	0.2	0.2	-1.3	0.1	0.6	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	2.6	1.6	0.8	-0.8	0.1	0.7	-0.1	-0.3	0.5	-0.9	-0.5	0.2
Father’s age at death	1.0	1.4	4.5	1.5	0.2	0.6	1.4	0.7	1.4	1.3	1.3	0.2	0.6	2.1
Worrier / anxious feelings	0.8	1.5	4.3	-0.5	-0.9	1.1	0.4	-2.1	0.3	-0.0	-1.6	1.5	0.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.4	-1.1	1.6	-0.3	0.3	0.3	-0.3	-0.5	0.2	-0.9	-1.4	-0.3
Falls in the last year	0.7	1.0	3.9	1.0	-0.6	1.0	1.4	-0.3	-0.0	-1.0	0.0	0.1	2.0	1.3
Hair/balding pattern: Pattern 3	2.2	3.3	12.5	1.8	-0.9	3.3	-1.4	-1.3	-1.9	0.0	-0.2	3.5	0.8	-1.0
Number of live births	1.8	2.5	4.8	0.6	1.2	0.4	1.7	2.0	1.9	2.2	2.1	-1.2	-0.5	1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	5.3	-2.2	1.4	0.4	-1.5	-1.7	-0.7	0.1	-2.0	1.3	-0.3	-2.3
Pulse rate	0.5	0.8	4.1	-2.0	0.6	-1.0	0.3	0.4	0.7	0.3	0.1	-1.3	-0.3	-0.8
Happiness	0.7	0.8	4.5	-0.9	-0.4	-1.0	-0.4	0.4	0.5	0.6	0.4	-1.2	-2.1	-0.3
Noisy workplace	0.4	0.5	1.9	0.3	1.1	-0.1	0.8	0.7	0.9	0.3	0.3	-0.0	0.1	1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.2	0.4	0.5	0.5	-0.1	0.4	0.1	0.6	-0.0	0.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.4	1.2	0.5	0.1	0.3	-0.2	0.2	-0.0	0.2	-0.1	0.3	0.2
Mouth/teeth dental problems: Dentures	0.6	1.1	2.7	1.6	1.1	-0.4	-0.2	1.5	-0.5	-0.2	1.7	-1.1	-0.9	0.8
Asthma	0.6	1.2	2.9	1.7	1.0	-0.2	1.5	1.1	0.9	1.2	1.1	-0.7	-1.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.9	0.3	-0.4	0.6	-1.6	-0.9	-1.2	-0.7	-1.1	0.4	-0.5	-2.0
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.3	-0.6	0.7	-0.5	-0.5	-0.7	-1.0	-0.4	0.6	0.1	-0.0
Depression (self-reported)	1.5	1.8	3.9	0.5	0.2	1.6	2.0	1.0	1.7	1.7	1.5	0.6	0.2	1.9
Medication: Lansoprazole	2.5	2.8	5.6	-0.6	2.4	0.1	1.8	2.1	1.8	1.9	1.9	-1.5	-1.3	1.7
Prospective memory result	0.5	0.6	1.8	-0.7	-0.3	-0.7	0.9	-1.0	0.8	-0.3	-1.0	-0.2	1.4	-0.5
Lung cancer (father)	0.4	0.4	1.2	1.1	-0.8	0.7	0.9	-0.5	-0.1	-0.3	0.3	0.3	0.8	0.7
Illnesses of mother	1.5	1.8	4.6	1.9	-1.5	-1.4	-2.1	0.6	-1.8	-1.4	-0.0	-1.3	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.5	-0.8	0.4	1.2	-1.4	-1.7	-0.7	-0.0	-1.9	1.5	0.6	-1.9
Pulse wave Arterial Stiffness index	1.8	2.1	5.1	-0.5	-2.2	0.7	0.4	-2.1	0.6	-0.3	-1.7	2.0	2.2	-0.4
Impedance of arm (left)	0.1	0.6	1.9	0.7	1.0	1.4	0.8	-0.2	0.7	0.7	0.3	0.9	-0.4	-0.3
Arm fat mass (right)	0.6	2.4	8.1	1.1	1.5	0.0	0.8	2.4	0.7	0.6	2.3	-1.5	-0.8	2.9
Trunk predicted mass	0.2	1.1	4.4	-2.0	2.1	-0.6	-1.0	0.2	-0.8	-0.8	-0.3	-0.4	0.2	-0.7
Standing height	0.3	2.9	10.4	-3.1	3.2	0.1	-1.1	-0.9	-0.5	-0.6	-1.4	0.7	0.6	-2.5
Length of working week for main job	1.1	1.3	3.7	-0.3	1.0	-1.9	-1.2	1.1	-0.6	-1.4	0.8	-1.7	-0.7	-0.3
Exposure to tobacco smoke at home	2.1	2.4	6.1	0.7	2.5	0.7	1.1	1.9	0.5	1.1	2.3	-0.3	-1.4	2.3
Breastfed as a baby	0.8	1.0	2.3	-1.2	-0.2	-0.3	-0.9	-1.3	-0.6	-1.1	-1.3	1.3	-0.2	-1.5
Tense / ‘highly strung’	1.7	2.7	9.4	-3.1	1.0	-2.0	-0.9	-0.4	-0.7	0.1	-1.1	-1.1	-2.5	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.3	0.7	0.4	0.6	-0.2	1.0	0.8	0.5	0.0	-0.9	-0.1
Hair/balding pattern: Pattern 4	1.3	3.1	15.3	3.9	-1.6	0.9	-1.0	-1.7	-1.1	-1.6	-1.6	1.6	-0.2	-1.6
Birth weight of first child	1.0	1.8	6.2	1.3	0.0	0.1	-1.0	-2.5	-1.0	-1.0	-1.5	1.1	-0.5	-2.3
Peak expiratory flow (PEF)	0.3	0.6	2.5	-1.5	1.6	0.3	-0.6	-0.1	0.3	0.6	-0.6	0.3	-0.5	-0.7
Pulse wave reflection index	1.5	1.8	6.8	0.3	-2.6	0.8	-0.5	-1.7	-0.3	-0.1	-1.3	2.1	1.7	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.6	0.5	-0.8	1.6	0.2	-0.3	0.5	0.1	-0.1	0.9	0.5	-0.2
Loud music exposure frequency	0.2	0.2	1.4	-1.2	-0.1	0.5	-0.5	-0.2	-0.1	0.1	0.1	-0.2	-0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	-0.0	-0.9	0.1	-0.7	-0.9	-0.7	-0.1	-0.4	-0.0	-0.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.6	1.0	0.9	-1.3	0.0	0.8	-0.0	-0.6	0.3	-1.0	-1.0	1.0
Blood clot in the leg (DVT)	0.6	0.7	3.3	-0.5	0.3	-1.8	-0.8	0.6	-0.6	-0.4	-0.1	-1.0	-1.5	-0.1
Medication: Paracetamol	0.3	0.5	3.1	-0.6	0.3	0.1	0.3	0.4	0.7	0.8	-0.1	-0.6	-1.8	-0.6
Headache pain in last month	0.5	0.9	3.4	1.5	1.8	0.8	1.0	0.5	1.2	0.7	0.5	0.1	-0.7	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	0.7	0.5	-1.1	-0.1	0.9	1.0	1.4	1.0	-1.3	-0.5	0.3
Glaucoma (self-reported)	0.5	0.6	1.6	1.2	0.8	1.1	0.8	-0.2	0.3	0.6	0.0	1.2	-0.9	0.0
Gout (self-reported)	0.9	1.2	2.8	1.5	-1.7	0.1	-0.6	-0.9	-1.3	-1.6	-1.2	-0.1	1.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.2	0.5	1.3	0.9	1.5	1.2	0.7	0.3	1.3	0.0	0.3	1.4
Medication: Amlodipine	1.6	2.2	5.5	-1.5	0.7	-0.1	-1.3	-1.6	-2.3	-2.2	-1.8	0.6	1.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.9	1.0	1.1	0.3	1.2	0.8	1.1	1.4	0.4	0.5	-0.4	0.7
Birth weight	1.2	2.6	6.1	-0.1	-2.5	-0.4	-1.8	-1.8	-2.1	-2.3	-1.8	0.6	0.7	-1.4
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.4	-0.3	1.6	-0.2	1.8	1.8	1.3	1.6	1.1	-0.9	-1.1	1.8
High blood pressure (siblings)	1.2	1.7	4.8	-0.6	-1.3	0.8	-0.9	-1.6	-1.2	-1.8	-1.1	1.2	2.2	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.3	3.9	0.0	1.0	0.8	-1.7	-1.1	-1.3	-0.5	-1.4	0.9	0.4	-2.0
Body fat percentage	0.7	2.9	8.8	1.3	1.4	0.7	1.6	2.2	1.4	1.4	2.5	-0.9	-0.7	3.0
Leg fat percentage (right)	0.6	2.3	9.3	1.1	0.7	0.3	1.2	2.0	1.0	1.2	2.4	-0.8	-0.4	3.1
Arm fat-free mass (right)	0.2	1.1	3.9	-2.0	1.2	-0.9	-1.4	0.3	-1.1	-0.9	-0.3	-0.9	0.2	-0.7
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-0.2	0.9	0.1	1.5	0.7	0.8	0.9	1.0	-0.5	-0.4	1.4
Comparative body size at age 10	0.4	1.1	4.9	0.6	-1.0	-0.7	-0.2	1.2	-0.5	-0.9	1.2	-1.3	-0.5	2.2
Number of full brothers	0.1	0.1	1.0	0.5	-0.0	0.0	0.4	-0.2	0.0	0.2	-0.2	-0.1	1.0	-0.3
Worry too long after embarrassment	0.1	0.2	0.6	0.1	0.5	0.6	0.5	0.5	0.1	0.2	0.8	-0.1	-0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.3	-1.5	-0.0	0.1	0.7	-0.2	0.8	1.3	-0.3	-0.1	-0.1	-0.2
Wheeze or whistling in the chest in last year	1.0	1.8	8.2	1.8	1.1	2.9	1.6	-0.1	0.9	0.2	0.6	1.5	1.2	0.5
Number of children fathered	0.5	0.5	2.3	0.2	-0.8	0.9	-0.0	-0.4	-0.8	-0.7	-0.5	0.4	1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	5.9	-1.6	1.4	1.6	1.3	0.4	1.7	2.4	0.9	0.9	-0.3	0.2
Age at first live birth	0.5	0.9	2.5	1.3	0.2	1.1	0.9	-0.6	1.1	1.6	-0.2	1.4	-0.1	0.2
Pulse wave peak to peak time	1.7	2.0	6.2	0.4	2.5	-0.5	-0.4	2.2	-0.5	0.4	1.6	-1.9	-2.1	0.3
Health satisfaction	0.5	0.6	2.5	-0.9	1.5	-0.3	0.6	0.2	0.4	0.2	-0.3	-0.3	-1.6	-0.4
Shortness of breath walking on level ground	0.9	1.1	3.3	-1.0	1.2	-0.3	1.8	1.1	1.4	-0.0	0.7	-0.7	-0.4	1.3
Qualifications: College or University degree	0.1	0.3	0.9	0.3	-0.8	0.6	-0.0	-0.9	0.1	0.7	-0.4	0.8	0.2	-0.4
Eye problems/disorders: None of the above	0.5	0.6	3.6	-0.9	-0.5	-1.9	-0.6	0.3	-0.0	-0.1	-0.1	-1.2	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	4.7	5.5	19.6	0.3	-1.3	-1.1	-3.2	-1.9	-3.7	-4.4	-1.9	0.5	1.2	-2.2
Emphysema/chronic bronchitis	0.6	0.7	2.3	-0.9	0.9	0.4	0.8	1.2	0.4	0.3	1.1	-0.2	0.2	1.5
Medication for pain relief, constipation, heartburn	0.3	0.6	2.8	0.3	-1.1	-0.8	0.4	-0.3	-0.1	-0.5	-0.1	0.2	1.7	0.8
Neck or shoulder pain in last month	0.7	1.0	5.2	1.0	2.3	0.9	-0.5	0.9	-0.7	0.1	1.2	0.0	-0.9	-0.5
Medication: Blood pressure	0.6	1.0	1.9	-0.8	-0.5	1.0	0.4	-1.4	-1.3	-1.3	-1.2	1.3	0.8	-0.4
Angina (self-reported)	0.4	0.5	1.4	0.3	0.4	0.4	-0.4	-1.2	-0.4	-0.8	-1.1	0.8	0.4	-0.7
Migraine (self-reported)	1.1	1.4	4.8	-0.2	1.2	0.1	-2.1	-0.6	-2.2	-1.5	-0.8	0.1	-0.6	-1.2
Medication: Ibuprofen	1.4	1.6	4.8	0.0	-0.6	1.6	-1.8	-1.6	-1.0	-0.0	-1.4	1.3	-0.1	-2.2
Medication: Allopurinol	0.6	0.9	5.0	2.2	-1.0	0.3	-0.2	-0.0	-0.8	-0.6	-0.3	-0.1	1.2	0.9
Medication: Omeprazole	0.6	0.8	2.4	-0.3	0.8	-0.1	0.8	1.2	1.2	0.6	1.6	-0.4	-0.2	1.1
Medication: Seretide 50 evohaler	0.7	0.8	3.7	-0.4	0.0	0.3	-0.2	-1.3	-0.3	-0.6	-1.3	0.6	0.5	-1.9
Mean time to correctly identify matches	0.2	0.4	1.2	0.8	-0.4	-1.1	-0.4	-0.2	-0.4	0.3	-0.4	-1.1	-0.5	-0.9
Heart disease (mother)	1.1	1.3	6.0	0.1	-1.0	2.4	0.6	-1.3	0.1	-0.6	-0.2	1.6	1.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.1	-0.6	-0.0	0.5	1.5	0.3	1.8	1.2	0.1	0.4	-0.1	0.5
Whole body fat mass	0.5	2.1	6.4	0.5	1.8	0.3	1.0	2.1	0.8	0.8	2.2	-1.2	-0.5	2.5
Leg fat mass (right)	0.5	1.9	7.3	0.9	1.3	0.2	0.7	2.0	0.4	0.5	2.2	-1.1	-0.3	2.7
Arm predicted mass (right)	0.2	0.9	4.2	-2.0	1.4	-0.8	-1.1	0.4	-0.8	-0.7	-0.2	-0.8	0.2	-0.5
Pulse rate, automated reading	0.3	0.8	4.3	-1.0	-0.2	-1.5	-0.1	0.3	0.6	-0.3	-0.2	-2.1	-0.7	-0.8
Alcohol intake frequency.	0.4	0.9	2.2	0.3	1.4	-1.3	-1.0	0.3	-1.5	-0.8	-0.4	-1.1	-0.8	-0.9
Comparative height size at age 10	0.7	3.6	15.4	-3.9	3.4	-2.0	-1.1	0.9	-0.7	-0.2	-0.7	-1.4	-0.7	-1.7
Number of full sisters	0.7	0.9	2.1	0.9	1.4	0.9	1.3	0.5	0.4	-0.4	1.1	-0.4	0.5	1.4
Suffer from ‘nerves’	1.9	2.9	6.0	-0.3	-0.2	-2.1	-2.4	-0.7	-2.3	-1.7	-1.1	-0.8	-2.5	-2.2
Overall health rating	0.3	0.6	3.3	-0.1	1.8	0.0	1.2	0.6	0.4	0.1	0.4	-0.3	-0.8	0.4
Chest pain or discomfort	0.4	0.6	1.4	1.2	0.6	-0.4	-0.9	-0.8	-1.0	-1.1	-0.5	0.6	0.3	-0.7
Had major operations	0.6	0.7	2.1	-1.0	1.5	1.0	0.8	-0.0	1.1	0.9	0.4	0.9	0.4	0.5
Age at last live birth	2.6	3.7	7.2	2.5	2.1	2.1	2.4	0.6	2.3	2.7	1.4	1.6	-0.3	1.6
Family relationship satisfaction	0.3	0.4	1.1	-0.2	0.1	0.6	0.2	0.4	0.6	0.8	0.9	0.0	-1.0	0.5
Leg pain on walking	0.2	0.2	1.0	0.5	0.6	-0.5	1.0	-0.3	0.4	-0.4	-0.1	-0.3	-0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.6	0.8	1.2	1.3	1.2	0.6	0.5	0.7	0.9	0.5	0.1	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	0.1	-0.6	0.3	0.1	0.5	0.6	-0.1	-0.3	-0.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.8	0.3	-0.2	-1.7	-0.9	0.8	-0.7	-0.7	-0.1	-1.3	-0.3	-0.1
Medication: Aspirin	0.6	0.8	4.1	-0.1	-0.1	2.0	-0.2	-1.0	0.1	0.2	-0.5	1.4	0.5	-0.8
Supplements: Vitamin C	1.3	1.5	6.1	-0.1	0.0	2.5	0.9	-1.1	0.6	1.7	-0.1	2.2	0.5	-0.5
Knee pain experienced in last month	0.6	1.0	4.1	-0.4	-0.2	-0.3	1.0	0.7	0.5	-0.4	0.3	-2.0	0.8	1.9
Hypertension (Self-reported)	0.8	2.2	4.1	-1.3	-0.6	1.0	-0.8	-2.0	-1.8	-2.0	-1.9	1.7	1.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.8	-0.3	0.5	-0.9	0.4	1.4	0.6	0.5	1.7	-1.9	-0.6	0.9
Illnesses of father: Heart disease	0.4	0.5	3.5	0.1	0.4	-0.8	-0.3	0.3	-0.1	-0.3	0.1	-0.4	-1.9	-1.1
Illnesses of siblings: Diabetes	2.5	3.1	6.4	-1.0	2.5	-1.5	1.0	2.4	1.3	1.0	1.8	-2.3	-2.1	1.5
Smoking status: Previous	0.4	0.7	3.0	-0.8	-0.8	-0.5	-0.0	1.1	-0.1	0.4	0.8	-0.7	0.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.0	-0.9	1.4	-0.3	-0.4	0.7	-0.4	-0.8	0.3	-0.8	0.2	0.2
Whole body fat-free mass	0.2	1.1	4.5	-1.5	2.1	-0.7	-1.1	0.6	-0.9	-0.9	0.2	-0.9	-0.1	-0.3
Leg fat-free mass (right)	0.3	1.6	5.8	-0.8	2.4	-1.0	-1.0	1.5	-0.8	-0.8	1.0	-1.7	-0.8	0.7
Arm fat percentage (left)	0.8	3.2	11.0	1.8	1.2	0.5	1.4	2.4	1.1	1.0	2.6	-1.1	-0.9	3.3
Average weekly red wine intake	2.1	3.1	8.4	-2.0	-2.6	2.4	0.4	-2.0	0.9	1.0	-0.9	2.9	1.7	-0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	0.5	1.0	-0.8	0.2	-0.2	-0.4	0.4	-0.1	-0.2	-1.1	-1.3
Mood swings	0.8	1.5	6.2	-0.5	2.3	-0.2	0.4	0.5	0.6	1.4	0.5	-0.9	-2.5	-0.9
Loneliness, isolation	0.5	0.7	1.7	0.2	0.4	1.3	1.0	-0.9	1.1	1.2	-0.2	0.8	-0.6	-0.3
Long-standing illness, disability or infirmity	0.5	0.8	3.3	0.8	1.8	0.5	0.5	0.9	-0.1	0.8	1.4	-0.2	-0.5	0.6
Ever had bowel cancer screening	1.4	1.6	3.7	-1.6	-1.2	-0.2	-0.1	-1.6	-0.5	-1.2	-1.9	0.8	1.9	-1.3
Diabetes diagnosed by doctor	0.4	0.7	2.8	-1.7	0.7	0.5	1.1	-0.3	1.0	0.0	-0.3	0.3	-0.7	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	8.1	0.9	2.4	0.6	0.8	1.2	1.3	1.8	1.5	0.0	-2.8	0.8
Friendships satisfaction	1.8	2.3	5.9	-1.5	-0.8	-1.1	-2.4	-0.8	-1.4	-0.3	-1.4	0.1	-2.1	-2.4
Qualifications: nursing, teaching	0.1	0.2	0.9	-0.9	-0.2	0.0	0.5	-0.1	0.6	0.8	0.0	-0.3	-0.3	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.3	0.3	0.7	-0.1	0.3	-0.5	-0.3	0.4	0.3	0.3	0.9
Eye problems/disorders: Cataract	1.0	1.2	3.3	0.1	0.9	0.7	0.9	1.8	0.8	0.3	1.8	-0.3	-0.3	1.8
Mouth/teeth dental problems: Mouth ulcers	3.9	6.2	13.4	1.5	-2.3	0.4	-2.9	-2.8	-3.1	-3.7	-2.7	0.7	0.9	-3.6
Medication for cholesterol	0.4	0.6	1.2	0.9	-0.9	0.9	1.1	-0.5	0.0	-0.4	0.5	0.7	1.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	0.3	0.2	0.1	-0.9	0.3	-0.4	-0.0	0.5	0.3	-0.8	-0.8
Back pain experienced in last month	1.1	1.5	5.1	0.5	0.6	0.5	-1.5	-0.9	-2.2	-2.3	-0.6	0.5	0.2	-1.6
Mineral and other dietary supplements	0.6	0.9	3.1	-0.1	-0.5	-0.3	-1.7	-0.6	-1.3	-1.6	-0.8	-0.1	-0.7	-0.6
Breast cancer (self-reported)	1.6	1.9	9.1	0.8	0.7	-3.0	0.5	1.3	0.1	-0.7	0.9	-2.6	-0.2	1.0
Asthma (self-reported)	0.9	1.8	4.0	2.0	1.2	0.1	1.7	1.4	1.1	1.4	1.6	-0.7	-0.9	1.5
Osteoporosis (self-reported)	1.2	1.5	5.2	-0.8	2.3	-0.9	1.1	0.5	1.5	1.7	0.4	-1.2	-1.3	-0.1
Osteoarthritis (self-reported)	2.9	3.8	10.8	0.1	1.8	-0.4	1.3	3.0	0.9	0.9	2.9	-1.8	-2.0	3.3
Medication: Aspirin	0.5	0.7	4.3	-0.1	0.3	2.1	0.0	-0.9	0.3	0.5	-0.3	1.3	0.3	-0.6
Medication: Gliclazide	0.7	0.8	2.3	-1.5	-1.5	0.6	0.8	-0.7	0.2	-0.7	-0.7	0.8	0.6	1.0
Illnesses of father: None of the above (group 1)	1.0	1.3	4.0	0.7	0.3	1.2	2.0	0.0	1.8	1.7	0.6	0.5	0.5	0.8
Smoking status: Current	0.8	1.3	3.1	0.3	0.9	0.8	1.1	1.8	1.2	1.2	1.6	-0.4	-0.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.5	-0.6	-1.2	1.3	-0.2	-2.0	0.2	0.2	-2.1	1.8	0.3	-1.8
Whole body water mass	0.2	1.1	4.4	-1.7	2.1	-0.8	-1.1	0.7	-0.9	-0.9	0.1	-1.0	-0.3	-0.2
Leg predicted mass (right)	0.3	1.6	6.0	-0.8	2.4	-1.1	-1.0	1.5	-0.8	-0.9	1.0	-1.8	-0.8	0.6
Arm fat mass (left)	0.5	2.0	6.5	0.9	1.3	-0.1	0.7	2.2	0.6	0.6	2.0	-1.5	-0.8	2.5
Number of self-reported non-cancer illnesses	1.1	1.8	4.4	1.4	2.0	2.1	2.1	0.0	1.1	0.9	0.6	1.3	-0.3	1.2
Average weekly champagne plus white wine intake	1.1	1.6	5.2	0.4	-0.4	2.0	-0.7	-1.5	-0.8	-0.7	-1.0	2.3	1.6	-0.3
Miserableness	0.3	0.5	2.4	-0.8	0.7	-0.3	0.1	0.6	0.2	0.4	0.5	-0.9	-1.6	-0.2
Guilty feelings	0.5	0.8	4.0	-1.1	-0.2	-0.5	0.5	0.5	0.3	1.0	0.5	-1.0	-2.0	0.1
Wears glasses or contact lenses	0.5	0.5	1.3	0.1	-1.1	0.2	0.2	-1.2	0.2	0.4	-1.0	0.9	0.9	-0.8
Ever taken oral contraceptive pill	1.1	1.2	7.7	0.7	-0.3	2.8	0.7	-0.9	0.2	0.1	0.2	1.7	0.4	0.0
Hearing aid user	0.6	0.7	1.9	-1.4	-0.3	-0.1	0.9	-0.4	0.9	1.1	-0.8	0.2	0.9	0.9
Mother’s age at death	0.3	0.3	2.1	1.5	0.0	-0.2	-0.4	0.3	-0.1	0.9	0.3	0.3	0.0	-0.6
Financial situation satisfaction	3.7	4.5	10.9	1.3	3.3	0.0	1.2	2.8	1.9	2.4	2.9	-1.6	-2.1	1.8
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.9	-0.6	0.9	-0.7	0.3	1.5	0.7	1.7	0.9	-1.1	-1.2	0.5
Commuting to job workplace: Public transport	0.5	0.6	1.7	0.3	-1.1	0.6	-0.6	-0.4	-1.0	-1.3	-0.4	0.4	1.3	-0.0
Eye problems/disorders: Glaucoma	0.8	0.9	2.8	1.7	0.7	0.9	0.9	-0.2	0.6	1.3	0.0	1.0	-1.3	-0.1
Medication: Blood pressure	0.2	0.3	1.2	-1.1	0.6	-0.7	0.1	0.5	0.5	0.3	-0.6	-0.4	-0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-0.7	-0.7	-0.6	-0.7	-0.5	-0.9	-0.6	-0.5	-0.6	-0.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.9	1.1	6.0	-0.7	-0.0	-0.1	1.6	0.5	1.6	2.4	0.3	-0.2	0.0	0.6
High cholesterol (Self-reported)	0.3	0.6	2.1	-0.5	1.4	-0.3	-1.1	-0.5	-0.7	-0.4	-0.7	0.2	-1.0	-1.0
Medication: Bendroflumethiazide	0.5	0.8	3.1	-1.8	0.5	-1.5	0.2	0.6	0.3	0.2	-0.3	-1.5	-0.3	0.4
Medication: Paracetamol	0.2	0.3	1.7	-0.4	0.0	0.5	0.1	-0.0	0.7	0.9	-0.1	0.1	-1.3	-0.2
Medication: Lisinopril	0.6	0.8	2.2	-0.5	-0.3	0.1	-1.2	-0.6	-1.5	-1.1	-1.1	1.2	0.2	-0.4
Medication: Atorvastatin	1.5	1.9	6.0	-0.5	-0.5	-1.6	-2.4	-0.4	-1.6	-1.2	-1.4	-0.6	-0.1	-2.2
Illnesses of father: High blood pressure	1.3	1.6	4.4	-0.8	-0.4	-0.0	-1.5	-1.4	-2.1	-1.9	-1.8	0.7	0.4	-1.2
Alcohol drinker status: Never	1.1	1.3	2.8	-0.0	-0.9	-1.3	-1.5	-1.1	-1.7	-1.0	-1.1	-0.6	0.1	-1.5
Ever smoked	0.6	1.0	3.9	-0.2	0.2	-0.7	-0.4	2.0	-0.6	-0.2	1.6	-1.1	-0.5	1.3
Basal metabolic rate	0.2	1.0	4.7	-1.2	2.2	-0.7	-0.8	1.1	-0.6	-0.7	0.6	-1.2	-0.3	0.3
Leg fat percentage (left)	0.7	2.4	9.3	1.0	0.7	0.3	1.5	2.0	1.1	1.4	2.2	-0.9	-0.5	3.0
Arm fat-free mass (left)	0.2	1.2	3.6	-1.6	1.9	-1.3	-1.0	1.0	-0.5	-0.5	0.4	-1.5	-0.4	-0.0
Number of operations (self-reported)	1.5	2.2	5.5	-2.0	-0.3	0.9	2.3	-1.7	2.2	1.5	-1.1	1.1	1.2	0.2
Average weekly beer plus cider intake	1.4	2.0	6.1	2.2	-0.3	-1.9	-1.2	1.0	-1.2	-1.7	0.4	-2.5	-0.7	0.1
Irritability	1.1	1.9	5.0	-1.2	-1.2	-1.3	-2.1	-0.4	-1.6	-0.9	-1.0	-1.0	-1.4	-2.2
Risk taking	0.5	0.8	2.7	1.0	-0.2	1.6	0.5	-1.3	0.1	0.5	-0.7	1.4	0.5	0.1
Ever had prostate specific antigen (PSA) test	1.9	2.1	5.6	-0.4	1.0	1.8	2.0	1.4	0.3	0.7	2.0	0.9	1.4	2.4
Fractured/broken bones in last 5 years	1.3	1.7	4.4	-0.1	1.5	1.4	2.1	0.1	2.0	1.6	0.0	0.6	1.0	1.3
Age started oral contraceptive pill	0.5	0.6	2.0	-0.4	-1.2	-0.2	0.4	-1.2	0.1	-0.2	-1.4	0.5	1.0	-0.6
Diastolic blood pressure, automated reading	1.1	3.3	15.6	-4.0	-1.6	-0.3	-0.6	-2.0	-0.6	-1.2	-3.0	0.8	1.0	-1.2
Ever depressed for a whole week	1.2	1.5	3.5	1.3	0.6	-1.0	0.4	1.6	0.8	0.9	1.7	-1.9	-1.5	1.1
Unable to work because of sickness or disability	0.6	0.8	2.3	0.2	1.5	0.0	1.3	0.3	1.0	1.5	1.0	-0.3	-0.6	0.7
Commuting to job workplace: Cycle	0.8	1.0	2.8	0.4	1.1	0.3	0.7	1.2	1.0	1.1	1.7	-0.3	-0.5	1.3
Myopia	0.8	1.1	1.8	1.2	-1.0	1.1	1.3	-1.2	1.0	1.3	-0.3	1.2	1.1	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.7	0.5	0.5	-1.4	0.4	1.6	1.3	1.5	1.5	-1.9	-1.4	0.4
Cholesterol lowering medication	1.6	2.3	6.4	-0.3	2.2	-2.3	-1.0	1.7	0.4	0.9	0.6	-2.1	-2.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.2	-0.2	0.8	-0.5	0.0	1.4	0.3	-0.1	1.5	-1.0	-0.3	0.7
Pain experienced in last month	0.8	1.4	6.1	-2.5	-1.8	-0.6	-0.1	-1.4	0.2	0.3	-1.4	0.9	0.6	-0.2
Supplements: Calcium	1.3	1.4	5.6	-2.4	1.5	-1.9	-0.2	0.8	-0.4	0.3	0.2	-1.5	-0.0	0.6
Basal cell carcinoma (self-reported)	2.9	3.5	11.2	0.6	1.5	0.5	3.4	1.4	2.5	2.8	2.0	-0.6	-0.6	1.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.6	1.1	0.2	0.4	1.3	0.8	0.9	0.7	-0.5	-0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.0	-0.5	0.5	-1.7	-0.7	0.7	-0.5	-0.1	0.0	-1.1	-1.6	0.0
Heart disease (siblings)	0.6	0.7	4.1	0.3	0.1	2.0	0.1	-0.8	0.2	0.2	-0.3	1.5	0.1	0.2
Alcohol drinker status: Previous	0.3	0.4	2.3	-1.5	0.3	-0.1	0.8	0.2	0.1	-0.3	0.0	-0.0	0.3	0.8
Pack years of smoking	1.3	2.0	6.7	0.3	2.6	0.7	1.2	1.6	1.9	1.7	1.5	-1.0	-0.1	1.0
Impedance of whole body	0.1	0.7	2.0	0.2	0.2	1.1	0.9	-1.0	0.8	0.7	-0.6	1.4	0.4	-0.9
Leg fat mass (left)	0.5	2.1	7.5	1.0	1.4	0.2	0.9	2.1	0.6	0.7	2.3	-1.2	-0.5	2.7
Arm predicted mass (left)	0.2	1.2	3.7	-1.9	1.5	-1.5	-1.0	0.7	-0.6	-0.7	-0.0	-1.4	-0.2	-0.2