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chr10:103,313,599-105,647,095

Best TWAS P=8.54e-19 · Best GWAS P=6.02e-16 conditioned to 0.493

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-7.96	8.9	8.5e-19	-0.94	0.00	1.00	TRUE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-7.96	8.0	1.3e-15	-1.00	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-7.42	-7.8	8.0e-15	0.64	0.03	0.58	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	-8.09	7.5	5.0e-14	-1.00	0.00	1.00	FALSE
24	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-7.56	7.5	9.1e-14	-0.45	0.07	0.90	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-7.43	-7.4	1.2e-13	0.44	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	-7.96	7.2	6.6e-13	-0.94	0.00	1.00	FALSE
4	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-6.73	7.1	1.2e-12	-0.92	0.04	0.90	FALSE
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-5.70	-6.7	1.8e-11	0.65	0.12	0.67	FALSE
45	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	-6.73	6.7	1.8e-11	-0.94	0.01	0.86	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	-5.94	-6.7	2.9e-11	0.77	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	-6.73	6.5	6.3e-11	-0.93	0.01	0.98	FALSE
5	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	-6.73	-6.5	6.6e-11	0.89	0.04	0.95	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	-6.04	6.5	6.8e-11	-0.43	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	-6.55	6.5	1.1e-10	-0.32	0.01	0.87	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	-6.41	6.4	1.5e-10	-0.85	0.03	0.65	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	-5.52	-6.4	1.9e-10	0.60	0.14	0.43	FALSE
3	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-6.04	6.4	2.0e-10	-0.37	0.37	0.39	FALSE
12	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-7.26	-6.3	3.0e-10	0.31	0.33	0.27	FALSE
14	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	-6.04	6.3	3.4e-10	-0.36	0.15	0.36	FALSE
31	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-7.75	-6.2	4.2e-10	0.25	0.02	0.98	FALSE
16	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	0.94	6.1	8.5e-10	-0.66	0.04	0.55	FALSE
22	GTEx	Pancreas	CYP17A1-AS1	0.11	0.06	lasso	5	0.06	1.1e-03	-7.96	-6.1	9.9e-10	0.85	0.02	0.83	FALSE
23	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-7.26	-6.1	1.1e-09	0.33	0.08	0.84	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	-8.09	6.1	1.3e-09	-0.93	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	ARL3	0.06	0.07	lasso	4	0.06	3.5e-06	-6.04	6.1	1.3e-09	-0.33	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	-5.52	6.1	1.3e-09	-0.68	0.25	0.58	FALSE
21	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	-5.89	-6.0	1.6e-09	0.77	0.31	0.51	FALSE
9	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	-3.71	-6.0	1.7e-09	0.67	0.04	0.75	FALSE
25	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-3.57	6.0	2.6e-09	-0.30	0.61	0.39	FALSE
13	GTEx	Cells Transformed fibroblasts	ARL3	0.07	0.00	enet	13	0.04	1.2e-03	-6.70	5.9	3.6e-09	-0.33	0.06	0.67	FALSE
30	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	-6.04	-5.8	5.1e-09	0.50	1.00	0.00	FALSE
19	GTEx	Muscle Skeletal	ARL3	0.07	0.05	lasso	3	0.06	9.0e-07	-4.81	5.8	5.3e-09	-0.28	0.93	0.03	FALSE
7	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	-5.94	-5.7	1.1e-08	0.79	0.07	0.79	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM180	0.06	0.03	lasso	5	0.03	3.7e-04	-5.42	-5.7	1.2e-08	0.29	0.01	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-5.70	-5.7	1.5e-08	0.32	0.08	0.06	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	-6.41	5.6	1.6e-08	-0.89	0.01	0.99	FALSE
17	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	-5.86	-5.6	2.4e-08	0.78	0.35	0.56	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	-6.04	5.6	2.5e-08	-0.30	0.01	0.61	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	-3.52	5.6	2.8e-08	-0.87	0.01	0.86	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARL3	0.02	0.01	blup	57	0.02	1.0e-05	-3.02	5.5	3.0e-08	-0.13	0.03	0.87	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	-5.86	-5.5	3.1e-08	0.78	0.18	0.27	FALSE
18	GTEx	Muscle Skeletal	TMEM180	0.05	0.01	lasso	6	0.01	8.3e-02	-4.25	-5.5	3.4e-08	0.14	0.11	0.15	FALSE
6	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	-5.94	-5.5	3.8e-08	0.61	0.11	0.74	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	-3.52	5.5	3.9e-08	-0.92	0.21	0.79	FALSE
2	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	3.04	5.3	1.3e-07	-0.70	0.16	0.56	FALSE
26	METSIM	Adipose	AS3MT	0.24	0.28	lasso	12	0.28	6.1e-43	-3.92	5.3	1.3e-07	-0.90	0.81	0.19	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	-3.52	5.2	2.4e-07	-0.86	0.02	0.97	FALSE
20	GTEx	Muscle Skeletal	RP11-18I14.10	0.10	0.01	enet	21	0.03	4.2e-04	-6.50	-5.2	2.5e-07	0.07	0.75	0.07	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM180	0.14	0.08	lasso	3	0.10	4.6e-10	-4.25	-5.1	3.0e-07	0.23	0.21	0.79	FALSE