Hub : Genes

SEZ6L2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.0510 0.0290 5.7e-03 0.009 NA 0.010 NA 0.003 1.0e-01 NA 9.4e-02 NA 2.2e-01
2 GTEx Cells Transformed fibroblasts 0.1080 0.0510 2.2e-03 0.076 NA 0.045 NA 0.075 2.3e-06 NA 2.4e-04 NA 2.9e-06
3 GTEx Nerve Tibial 0.0666 0.0314 3.4e-03 0.019 NA 0.045 NA 0.029 1.7e-02 NA 3.9e-04 NA 3.5e-03
4 ROSMAP Brain Pre-frontal Cortex 0.1199 0.0391 6.9e-08 0.085 0.072 0.078 0.081 0.086 4.8e-11 1.5e-09 2.7e-10 1.3e-10 4.0e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 3.0 4.8 12.2 -3.5 -1.4 -1.8 1.3
Bipolar Disorder or Schizophrenia 4.9 11.9 36.8 -6.1 -1.7 -2.5 1.4
Depressed Affect (Nagel 2018) 1.3 2.8 6.9 2.6 1.6 0.1 -1.3
Depression (Nagel 2018) 0.1 0.2 0.3 0.1 0.5 0.5 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.3 1.1 -0.1 0.9 -0.3
Neuroticism (Nagel 2018) 0.1 0.2 0.3 0.0 0.6 -0.6 -0.3
Schizophrenia (2018) 3.4 7.0 24.0 -4.9 -1.0 -1.5 0.8
Schizophrenia vs Biploar Disorder 0.6 0.7 1.5 -0.3 0.9 1.2 -0.8
Worry (Nagel 2018) 2.4 5.1 13.7 -3.7 -1.1 -2.1 1.1
Alzheimer’s Disease (in mother) 2.2 2.6 3.4 -1.9 -1.5 -1.4 1.6
Alzheimer’s Disease (in father) 1.3 1.4 2.0 -1.4 1.4 0.4 -1.2
Alzheimer’s Disease (including proxy) 2.5 3.6 6.9 -2.6 -1.4 -1.6 1.6
Crohns Disease (2017) 0.3 0.6 2.4 -1.6 0.1 0.3 -0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.1 -0.1 0.5 0.2
Ulcerative Colitis (UC) 0.3 0.6 2.0 1.4 -0.1 0.6 0.2
Major Depression (MDD) 0.6 0.8 3.1 -1.8 0.0 0.0 0.0
Reaction Time 0.2 0.3 0.4 -0.6 0.5 0.7 -0.6
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.3 0.5 -0.5 0.4 0.4
Breast Cancer 0.3 0.8 1.2 0.6 1.1 0.7 -1.0
Ovarian Cancer 0.0 0.1 0.2 0.1 0.2 0.4 -0.1
Prostate Cancer 0.7 1.0 2.2 -1.5 0.8 0.7 -0.9
Age at First Birth 0.4 0.6 0.9 -0.3 0.9 0.8 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.6 3.5 8.0 2.8 1.5 1.1 -1.5
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.5 0.8 3.1 -1.8 -0.2 -0.4 0.1
Mean Putamen Volume 1.1 1.3 3.8 1.9 0.7 0.6 -0.6
Fasting Glucose 0.3 0.3 0.6 -0.6 0.8 -0.1 -0.5
HbA1C 0.2 0.2 0.8 0.9 -0.1 -0.3 0.3
HDL Cholesterol 0.7 1.1 2.0 -0.4 -1.2 -0.9 1.4
LDL Cholesterol 0.7 1.1 1.5 -1.2 -1.2 -0.3 1.2
Lupus 4.1 6.3 10.0 0.3 -3.1 -2.3 3.2
Neuroticism (2016) 1.4 2.0 3.1 -1.1 1.6 1.1 -1.8
Primary Biliary Cirrhosis 0.6 0.8 3.3 1.8 -0.1 -0.0 0.1
Rheumatoid Arthritis 1.7 2.3 3.0 1.2 1.7 1.5 -1.7
Schizophrenia (2014) 3.5 7.7 25.8 -5.1 -1.1 -1.6 1.0
Triglycerides 0.2 0.3 0.4 0.7 0.6 0.0 -0.7
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.7 1.0 4.0 2.0 0.1 -0.1 0.2
Blood Eosinophil Count 1.8 13.9 40.2 -6.3 -2.7 -0.4 2.8
Blood Platelet Count 0.3 3.0 5.3 -1.3 -2.3 -0.8 2.0
Blood Red Count 6.0 58.4 213.2 -14.6 -3.0 -2.4 2.5
Blood White Count 0.7 5.4 6.8 -2.0 -2.2 -2.5 2.6
Heel T-Score 2.0 15.6 41.1 -6.4 -2.3 -3.5 1.9
BMI 11.3 65.7 130.0 11.4 6.4 7.2 -6.4
Height 2.4 46.5 76.0 8.7 6.5 5.0 -6.5
Waist Hip Ratio (WHR) 1.9 8.4 14.3 1.4 2.9 3.8 -3.0
Systolic Blood Pressure 0.9 4.7 8.1 0.4 2.6 1.9 -2.9
Smoking Status 0.3 0.7 1.2 0.9 1.1 -0.0 -1.0
Allergy or Eczema 2.4 6.4 10.0 -1.0 -3.1 -2.3 3.2
Cardiovascular Disease 0.5 1.8 2.6 1.0 1.3 1.6 -1.3
Hypothyroidism (self reported) 0.3 0.7 1.9 -1.4 -0.7 0.1 0.5
Respiratory disease 0.8 1.7 4.7 2.2 0.7 1.2 -0.6
Type 2 Diabetes (T2D) (2018) 1.3 2.4 2.8 1.7 1.3 1.6 -1.6
Lung FEV1/FVC ratio 0.6 3.2 12.5 -3.5 0.1 -0.6 -0.1
Lung FVC 0.4 2.0 2.2 -1.5 -1.5 -1.4 1.4
Neuroticism 0.5 1.2 2.5 0.0 1.6 0.3 -1.5
Chronotype (morning person) 3.2 7.4 8.4 2.9 2.4 2.9 -2.7
Hair Pigment 0.0 0.1 0.1 0.3 0.1 -0.2 0.3
Tanning 0.5 5.5 7.5 -1.5 -2.5 -2.7 2.5
Hand grip strength (left) 2.6 6.7 9.8 3.1 2.8 1.4 -2.7
Number of treatments/medications taken 0.9 1.6 2.0 1.4 1.4 0.9 -1.3
Average weekly spirits intake 2.4 3.0 4.8 0.4 -1.8 -2.2 1.9
Sensitivity / hurt feelings 0.3 0.6 0.8 -0.9 -0.7 -0.9 0.5
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.7 0.8 0.8 0.1 -0.8
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.6 0.1 0.6 0.0
Relative age of first facial hair 1.2 2.6 7.8 -2.8 0.5 -1.4 -0.5
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 5.9 -2.4 -0.9 -1.0 0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.6 0.8 0.7 0.6 -0.4
Ever had hysterectomy (womb removed) 1.0 1.1 4.0 -2.0 -0.5 -0.4 0.3
Systolic blood pressure, automated reading 0.9 2.5 3.3 1.2 1.7 1.5 -1.8
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.1 -0.5 0.4 0.4
Angina 2.0 2.6 5.0 0.4 2.1 0.8 -2.2
Medication for hormone replacement therapy 1.0 1.1 2.2 -0.6 1.5 0.6 -1.3
Vitamin and mineral supplements 0.1 0.1 0.4 -0.7 0.3 0.1 -0.1
Supplements: Zinc 0.4 0.5 0.9 0.9 0.4 0.9 -0.3
Medication: Co-codamol 1.4 1.7 3.1 0.4 1.6 1.0 -1.8
Medication: Metformin 0.6 0.9 3.3 1.8 0.2 0.2 -0.3
Diabetes (father) 3.6 4.5 15.4 3.9 0.2 1.6 -0.0
Diabetes (mother) 6.9 8.8 14.8 1.7 2.8 3.8 -3.1
Severe depression (siblings) 0.2 0.2 0.4 0.0 0.5 0.4 -0.6
Pack years adult smoking proportion 0.4 0.6 1.0 0.9 -0.7 -0.1 1.0
Impedance of leg (right) 11.1 53.7 116.6 -10.8 -6.0 -5.4 5.8
Leg fat-free mass (left) 14.3 75.8 166.4 12.9 7.0 6.4 -6.9
Trunk fat percentage 4.5 18.1 39.6 6.3 2.8 4.0 -3.0
Hand grip strength (right) 1.1 2.9 5.4 2.3 1.8 0.4 -1.6
Townsend deprivation index at recruitment 0.6 0.8 1.4 0.4 1.2 0.7 -1.2
Current tobacco smoking 0.5 0.9 1.3 1.0 1.1 0.4 -1.0
Average weekly fortified wine intake 8.9 10.4 14.8 -2.3 -3.8 -2.9 3.6
Maternal smoking around birth 1.5 2.2 5.0 2.2 -0.9 -1.5 0.8
Fed-up feelings 2.7 4.9 12.4 3.5 2.0 0.4 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.6 3.8 1.2 1.6 1.9 -1.6
Relative age voice broke 1.3 2.1 4.8 -2.2 0.3 -1.8 0.0
Taking other prescription medications 0.5 0.7 2.4 1.5 0.4 0.5 -0.3
Age when periods started (menarche) 12.6 30.3 33.9 -5.3 -5.5 -5.8 5.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 0.8 0.1 0.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.5 4.9 -2.2 0.5 -0.5 -0.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.2 -0.9 -0.7 -1.8 0.8
Qualifications: CSEs or equivalent 1.3 1.7 2.2 1.5 1.3 -1.2 -1.3
Serious illness, injury or assault to yourself 1.9 2.3 3.4 1.1 1.9 1.1 -1.8
High blood pressure 1.5 4.3 5.6 1.6 2.2 2.0 -2.4
Hayfever, allergic rhinitis or eczema 2.1 4.5 7.8 0.5 -2.7 -1.6 2.8
Multivitamins +/- minerals 0.8 1.0 2.9 1.7 0.5 0.7 -0.7
Stomach or abdominal pain in last month 0.2 0.3 1.1 -1.0 0.1 -0.4 0.1
Supplements: Glucosamine 1.4 1.9 4.0 2.0 -1.2 -0.6 1.3
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 3.0 -1.7 -0.3 -0.1 -0.1
Medication: Atenolol 0.3 0.3 1.0 0.1 0.4 1.0 -0.4
Medication: Levothyroxine sodium 0.4 0.7 2.8 0.0 0.2 1.7 -0.3
Sitting height 0.8 5.8 7.6 2.8 2.4 2.1 -2.3
Chronic bronchitis/emphysema (father) 2.2 2.6 3.8 1.0 2.0 1.6 -1.7
High blood pressure (mother) 0.4 0.6 2.4 1.6 -0.1 -0.2 -0.1
Body mass index (BMI) 12.2 51.9 117.0 10.8 5.4 5.8 -5.3
Impedance of leg (left) 9.8 47.6 104.0 -10.2 -5.6 -5.0 5.4
Leg predicted mass (left) 14.4 76.4 166.4 12.9 7.0 6.5 -6.9
Trunk fat mass 9.3 39.8 86.9 9.3 4.6 5.5 -4.7
Waist circumference 17.4 63.5 125.4 11.2 6.1 7.4 -6.1
Number of incorrect matches in round 8.7 14.5 36.7 -6.1 -2.4 -2.9 2.7
Past tobacco smoking 0.3 0.5 0.7 -0.9 -0.7 -0.4 0.7
Alcohol usually taken with meals 0.4 0.7 2.0 1.4 0.1 0.7 -0.3
Nervous feelings 3.7 6.9 18.1 -4.3 -1.3 -2.6 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 4.7 -2.2 0.1 -1.1 -0.1
Hearing difficulty/problems with background noise 0.4 0.6 1.4 -1.2 0.6 0.7 -0.4
Hair/balding pattern: Pattern 2 0.6 0.7 1.3 -0.4 -0.9 -1.2 0.8
Had menopause 0.4 0.5 1.2 -0.8 0.0 1.1 0.0
Had other major operations 0.2 0.2 0.3 0.5 0.5 -0.3 -0.5
Forced vital capacity (FVC) 1.1 4.4 8.1 2.8 2.1 1.3 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.5 -1.9 -0.4 -0.8 0.3
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 4.8 -2.2 0.1 -0.5 -0.3
Qualifications: None of the above 0.3 0.7 1.3 0.7 0.8 1.1 -0.7
Financial difficulties in last 2 years 0.9 1.3 1.8 1.1 1.3 0.5 -1.3
Mouth/teeth dental problems 3.5 5.4 6.4 -2.4 -2.5 -1.9 2.4
Heart attack 0.0 0.0 0.1 -0.1 0.3 -0.1 -0.1
Allergy 0.4 1.0 1.5 -0.5 1.2 0.9 -1.2
Pain all over the body in last month 3.3 3.5 5.5 0.9 2.3 1.6 -2.3
Diabetes (self-reported) 0.6 0.9 2.0 1.4 0.4 0.9 -0.7
Hayfever/allergic rhinitis (self-reported) 3.0 4.0 6.1 -0.9 -2.2 -2.1 2.5
Medication: Ramipril 0.3 0.4 0.9 0.2 0.6 1.0 -0.6
Medication: Simvastatin 0.5 0.7 1.8 -1.3 -0.7 -0.2 0.6
Fluid intelligence score 0.8 1.6 2.5 0.6 -1.6 -1.1 1.5
Illnesses of siblings 0.7 1.0 2.0 -0.3 -1.1 -1.4 0.9
Neuroticism score 1.4 2.9 5.9 0.1 2.4 0.8 -2.3
Weight 15.9 78.2 163.8 12.8 7.0 7.3 -6.9
Impedance of arm (right) 6.5 30.4 79.0 -8.9 -4.2 -3.0 4.0
Arm fat percentage (right) 8.6 33.8 67.2 8.2 4.4 5.3 -4.5
Trunk fat-free mass 12.8 73.7 161.3 12.7 6.9 6.4 -6.7
Hip circumference 11.9 51.5 123.2 11.1 5.0 5.8 -4.9
Time employed in main current job 1.4 1.6 5.9 -2.4 0.3 0.3 -0.6
Alcohol intake versus 10 years previously 7.8 11.6 16.7 4.1 3.3 2.9 -3.2
Father’s age at death 0.1 0.2 0.4 0.6 0.2 0.4 -0.1
Worrier / anxious feelings 2.0 3.7 6.1 -2.5 -1.6 -1.9 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.2 -0.4 1.5 0.4 -1.5
Falls in the last year 0.1 0.1 0.3 0.1 -0.5 -0.1 0.5
Hair/balding pattern: Pattern 3 1.0 1.5 3.9 -2.0 -0.7 -1.3 0.3
Number of live births 1.1 1.6 3.3 -1.8 -1.0 -1.0 1.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 3.3 1.7 1.8 1.3 -1.6
Pulse rate 1.2 2.1 2.8 -1.7 -1.2 -1.6 1.3
Happiness 0.3 0.4 1.4 -1.2 0.1 -0.2 -0.1
Noisy workplace 0.1 0.2 0.5 0.7 -0.3 -0.3 0.0
Qualifications: A levels/AS levels or equivalent 0.9 1.9 2.9 -1.5 -1.7 -0.5 1.5
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.9 2.0 -0.7 -1.0 0.8
Mouth/teeth dental problems: Dentures 3.3 5.6 8.8 3.0 2.2 2.0 -2.2
Asthma 1.2 2.4 6.9 2.6 1.1 0.7 -1.1
Medication: Ibuprofen (e.g. Nurofen) 6.1 7.7 10.4 3.2 2.6 2.6 -2.6
Medication: Cholesterol lowering 0.3 0.4 0.7 -0.8 -0.5 -0.7 0.4
Depression (self-reported) 0.3 0.4 0.6 -0.3 0.8 0.5 -0.7
Medication: Lansoprazole 0.0 0.1 0.1 0.1 0.2 -0.3 -0.3
Prospective memory result 0.9 1.1 2.0 -0.4 1.1 1.4 -1.0
Lung cancer (father) 0.7 0.8 1.4 0.1 1.2 0.7 -1.2
Illnesses of mother 0.3 0.4 1.4 -1.2 0.2 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.8 0.3 0.9 0.3 -0.7
Pulse wave Arterial Stiffness index 0.6 0.7 1.0 0.3 0.9 1.0 -0.9
Impedance of arm (left) 7.7 35.6 85.2 -9.2 -4.7 -3.9 4.5
Arm fat mass (right) 14.2 58.3 127.7 11.3 5.8 6.3 -5.7
Trunk predicted mass 12.8 73.2 158.8 12.6 6.9 6.4 -6.7
Standing height 2.4 23.8 42.5 6.5 4.2 4.2 -4.2
Length of working week for main job 0.9 1.0 1.1 1.0 1.0 1.1 -0.9
Exposure to tobacco smoke at home 1.6 1.8 2.8 1.2 1.3 1.7 -1.2
Breastfed as a baby 0.3 0.4 0.9 0.2 -1.0 0.2 0.8
Tense / ‘highly strung’ 2.7 4.4 17.3 -4.2 -0.1 -0.6 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.7 -2.4 -0.1 -1.1 -0.0
Hair/balding pattern: Pattern 4 0.2 0.5 0.6 0.3 0.7 0.8 -0.8
Birth weight of first child 0.7 1.2 3.4 1.8 0.9 0.0 -0.9
Peak expiratory flow (PEF) 0.4 1.0 2.2 -0.1 1.0 1.5 -0.9
Pulse wave reflection index 0.4 0.5 0.9 0.4 0.7 1.0 -0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.0 0.7 0.8 0.7 -1.0
Loud music exposure frequency 0.6 0.7 1.6 -0.0 -0.6 -1.3 0.9
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.5 -1.1 -1.2 -0.2 1.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.4 0.4 1.2 0.4 -1.2
Blood clot in the leg (DVT) 1.0 1.2 1.7 -1.1 1.2 0.8 -1.3
Medication: Paracetamol 4.5 7.5 12.5 0.8 3.5 2.3 -3.4
Headache pain in last month 1.0 1.8 3.3 -0.9 1.8 0.8 -1.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 0.1 -0.8 0.1 0.8
Glaucoma (self-reported) 1.3 1.5 3.9 2.0 0.9 0.7 -0.9
Gout (self-reported) 0.4 0.6 2.2 1.5 0.1 -0.2 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.2 -1.1 0.0 0.7 -0.2
Medication: Amlodipine 1.0 1.5 2.7 -0.7 1.6 0.5 -1.6
Medication: Ventolin 100micrograms inhaler 0.8 1.1 4.2 2.1 0.2 0.1 0.2
Birth weight 0.7 1.6 2.9 1.7 1.3 0.0 -1.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.3 0.4 -0.3 -1.1 0.3
High blood pressure (siblings) 0.9 1.4 2.0 -0.5 1.4 1.1 -1.4
Forced vital capacity (FVC), Best measure 0.6 2.1 3.4 1.8 1.6 0.8 -1.4
Body fat percentage 5.1 20.1 42.4 6.5 3.1 4.2 -3.2
Leg fat percentage (right) 3.4 12.3 26.5 5.1 2.4 3.3 -2.5
Arm fat-free mass (right) 12.8 65.6 151.3 12.3 6.4 5.6 -6.3
Exposure to tobacco smoke outside home 0.2 0.3 0.9 -0.9 -0.0 -0.7 -0.1
Comparative body size at age 10 6.4 17.8 20.9 4.6 4.1 4.0 -4.2
Number of full brothers 0.7 0.9 1.7 0.5 1.3 0.4 -1.2
Worry too long after embarrassment 0.2 0.3 0.5 -0.7 0.5 0.3 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 7.3 -2.7 -0.5 -0.7 0.4
Wheeze or whistling in the chest in last year 4.1 7.3 15.0 3.9 2.4 1.7 -2.3
Number of children fathered 1.7 1.9 6.0 2.5 1.0 0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 1.4 -1.2 -0.9 -1.0 1.0
Age at first live birth 0.2 0.4 0.9 -0.3 -1.0 -0.1 0.8
Pulse wave peak to peak time 0.5 0.6 1.0 0.1 -0.8 -1.0 0.8
Health satisfaction 4.2 5.5 7.4 -0.4 2.7 2.7 -2.7
Shortness of breath walking on level ground 1.5 1.8 3.2 0.5 1.3 1.8 -1.4
Qualifications: College or University degree 2.3 7.2 8.7 -2.4 -2.8 -2.5 3.0
Eye problems/disorders: None of the above 0.6 0.7 1.2 -0.3 1.1 -0.6 -1.1
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 0.8 -0.2 1.0 0.1
Emphysema/chronic bronchitis 0.4 0.5 0.9 0.9 -0.6 -0.3 0.7
Medication for pain relief, constipation, heartburn 5.7 9.7 12.9 -2.0 -3.6 -3.3 3.4
Neck or shoulder pain in last month 2.1 3.0 8.1 2.8 0.9 1.4 -1.0
Medication: Blood pressure 1.9 3.4 5.9 1.2 2.4 1.2 -2.2
Angina (self-reported) 1.4 1.8 3.7 0.1 1.8 0.5 -1.9
Migraine (self-reported) 1.5 1.8 2.4 -1.4 -1.4 -1.0 1.5
Medication: Ibuprofen 2.5 3.0 4.3 2.1 1.7 1.4 -1.7
Medication: Allopurinol 0.1 0.2 0.6 0.8 0.3 -0.0 -0.1
Medication: Omeprazole 0.2 0.3 0.6 0.8 0.5 0.2 -0.4
Medication: Seretide 50 evohaler 1.0 1.1 3.1 1.8 0.5 1.0 -0.3
Mean time to correctly identify matches 0.4 0.8 2.8 -1.7 -0.1 0.7 0.1
Heart disease (mother) 0.1 0.2 0.6 0.8 -0.1 -0.1 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.2 -0.1 0.1 0.4 -0.1
Whole body fat mass 10.7 44.7 97.6 9.9 4.9 5.8 -4.9
Leg fat mass (right) 9.6 37.3 85.2 9.2 4.4 5.0 -4.4
Arm predicted mass (right) 12.9 66.1 153.8 12.4 6.3 5.7 -6.2
Pulse rate, automated reading 0.2 0.7 2.0 -1.4 -0.6 -0.2 0.7
Alcohol intake frequency. 14.1 32.8 40.4 4.0 6.4 5.9 -6.3
Comparative height size at age 10 5.1 27.9 58.7 7.7 3.9 4.9 -3.7
Number of full sisters 0.9 1.1 1.6 1.1 0.8 1.2 -1.1
Suffer from ‘nerves’ 1.8 2.8 9.4 -3.1 0.1 -1.3 -0.1
Overall health rating 0.5 1.1 1.6 0.6 1.2 1.0 -1.3
Chest pain or discomfort 2.0 2.9 5.8 -0.4 2.2 0.8 -2.4
Had major operations 0.2 0.2 0.3 -0.5 0.4 -0.1 -0.6
Age at last live birth 0.9 1.3 2.2 -1.0 0.9 1.5 -1.0
Family relationship satisfaction 0.6 0.8 1.4 -0.3 1.0 0.7 -1.2
Leg pain on walking 1.5 1.8 5.5 2.3 0.9 0.7 -0.8
Qualifications: NVQ or HND or HNC or equivalent 4.0 4.8 13.0 3.6 1.5 1.5 -1.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 0.7 -0.5 0.0 0.5
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.6 -1.3 -1.2 -0.3 1.3
Medication: Aspirin 0.5 0.7 0.9 -0.9 0.8 0.8 -0.8
Supplements: Vitamin C 0.5 0.6 2.2 -1.5 0.1 0.5 -0.1
Knee pain experienced in last month 1.3 2.1 2.8 0.9 1.7 1.4 -1.6
Hypertension (Self-reported) 1.1 3.0 3.9 1.3 1.9 1.7 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.6 1.6 1.2 0.8 -1.1
Illnesses of father: Heart disease 0.3 0.4 0.7 0.3 0.5 0.9 -0.6
Illnesses of siblings: Diabetes 0.5 0.6 1.6 1.2 0.5 0.6 -0.5
Smoking status: Previous 0.2 0.2 0.4 0.7 0.5 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 8.4 2.9 1.0 0.5 -0.9
Whole body fat-free mass 14.1 80.4 176.9 13.3 7.2 6.6 -7.0
Leg fat-free mass (right) 14.9 79.6 174.2 13.2 7.2 6.5 -7.1
Arm fat percentage (left) 8.0 32.0 65.9 8.1 4.3 5.0 -4.3
Average weekly red wine intake 0.1 0.2 0.6 -0.7 -0.2 -0.0 -0.0
Handedness (chirality/laterality): Left-handed 2.0 2.4 5.7 0.8 1.3 2.4 -1.3
Mood swings 0.2 0.3 0.6 0.8 0.7 -0.3 -0.5
Loneliness, isolation 3.9 5.3 5.7 2.3 2.4 2.1 -2.4
Long-standing illness, disability or infirmity 0.6 1.0 2.7 1.7 0.6 0.7 -0.7
Ever had bowel cancer screening 0.3 0.4 0.7 -0.7 0.4 0.8 -0.6
Diabetes diagnosed by doctor 0.4 0.7 1.9 1.4 0.3 0.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 -0.2 0.1 1.0 -0.4
Friendships satisfaction 2.2 2.7 4.2 -0.4 1.9 1.7 -2.0
Qualifications: nursing, teaching 1.2 1.8 3.2 -1.2 -1.8 -0.5 1.5
Commuting to job workplace: Walk 0.4 0.5 0.8 -0.7 -0.7 -0.1 0.9
Eye problems/disorders: Cataract 5.3 6.2 7.7 -2.6 -2.7 -1.7 2.8
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.4 -0.6 -0.7 0.6
Medication for cholesterol 3.3 4.9 7.3 0.2 -2.7 -2.3 2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.2 0.0 0.6 0.0
Back pain experienced in last month 0.1 0.2 0.4 0.6 0.5 0.2 -0.4
Mineral and other dietary supplements 0.4 0.5 1.1 -1.0 0.6 0.3 -0.7
Breast cancer (self-reported) 0.3 0.4 0.9 0.9 -0.5 -0.6 0.5
Asthma (self-reported) 1.5 3.1 8.1 2.9 1.2 1.1 -1.2
Osteoporosis (self-reported) 0.5 0.6 1.2 0.1 -1.1 -0.5 1.0
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.3 -0.4 -0.4 0.3
Medication: Aspirin 0.7 0.9 1.0 -0.9 1.0 1.0 -1.0
Medication: Gliclazide 0.4 0.5 1.5 1.2 -0.4 -0.5 0.3
Illnesses of father: None of the above (group 1) 3.0 3.7 4.1 -2.0 -1.9 -2.0 1.8
Smoking status: Current 0.3 0.4 0.6 0.8 0.8 0.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 11.0 -3.3 -0.9 -1.7 1.2
Whole body water mass 14.4 81.9 182.2 13.5 7.2 6.6 -7.1
Leg predicted mass (right) 14.9 79.4 171.6 13.1 7.2 6.6 -7.1
Arm fat mass (left) 13.7 56.4 127.7 11.3 5.6 6.0 -5.5
Number of self-reported non-cancer illnesses 0.1 0.2 0.7 -0.8 -0.4 0.1 0.2
Average weekly champagne plus white wine intake 2.6 3.6 5.0 -1.6 -2.2 -1.7 1.9
Miserableness 1.0 1.7 3.6 1.9 1.4 -0.1 -1.2
Guilty feelings 9.8 14.8 19.7 1.4 4.3 4.4 -4.3
Wears glasses or contact lenses 0.5 0.6 1.0 1.0 -0.7 -0.5 0.8
Ever taken oral contraceptive pill 0.7 0.8 2.9 1.7 0.5 0.1 -0.4
Hearing aid user 0.2 0.2 0.4 0.6 0.4 0.6 -0.1
Mother’s age at death 1.2 1.5 4.1 -0.6 0.9 2.0 -0.8
Financial situation satisfaction 1.5 1.9 2.2 1.2 1.5 1.4 -1.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.0 -1.4 -0.4 0.6 0.2
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.4 0.4 -0.0 -0.4
Eye problems/disorders: Glaucoma 1.8 2.2 6.0 2.4 0.8 1.3 -0.7
Medication: Blood pressure 2.6 5.0 6.9 1.3 2.3 2.6 -2.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.0 -0.5 -0.4 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.8 0.9 -0.2 0.5 0.4
High cholesterol (Self-reported) 0.6 1.1 3.7 -1.9 -0.4 0.4 0.3
Medication: Bendroflumethiazide 3.6 5.4 6.2 2.5 2.3 2.1 -2.4
Medication: Paracetamol 2.9 4.4 7.9 -0.4 2.8 1.5 -2.7
Medication: Lisinopril 1.1 1.4 2.6 0.4 1.6 0.4 -1.6
Medication: Atorvastatin 0.8 1.0 2.4 -0.9 -0.6 -1.6 0.6
Illnesses of father: High blood pressure 1.3 1.6 2.8 1.7 -0.9 -1.3 1.1
Alcohol drinker status: Never 1.4 1.7 2.6 0.4 1.6 1.2 -1.6
Ever smoked 0.3 0.5 0.7 -0.1 0.8 0.8 -0.8
Basal metabolic rate 15.2 84.3 187.7 13.7 7.2 6.8 -7.1
Leg fat percentage (left) 4.5 16.4 34.2 5.8 2.9 3.8 -3.0
Arm fat-free mass (left) 14.3 72.5 163.8 12.8 6.7 6.2 -6.6
Number of operations (self-reported) 0.2 0.3 0.7 0.8 0.3 0.3 -0.4
Average weekly beer plus cider intake 0.8 1.1 1.8 0.0 -1.1 -1.2 1.4
Irritability 1.4 2.3 4.1 0.6 2.0 1.1 -1.9
Risk taking 0.6 0.9 2.9 1.7 0.7 0.2 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.3 -0.6 0.6 -0.4 -0.5
Fractured/broken bones in last 5 years 1.1 1.4 1.8 1.4 -1.0 -1.2 1.1
Age started oral contraceptive pill 0.5 0.6 0.8 -0.7 -0.9 0.7 0.9
Diastolic blood pressure, automated reading 0.6 1.9 2.3 1.2 1.5 1.3 -1.5
Ever depressed for a whole week 1.1 1.4 3.2 -1.3 -0.6 -1.8 0.5
Unable to work because of sickness or disability 0.0 0.1 0.1 -0.3 -0.3 -0.1 0.1
Commuting to job workplace: Cycle 1.2 1.5 3.5 -1.9 0.8 0.9 -0.9
Myopia 0.7 1.0 1.8 -0.1 -1.3 -0.9 1.2
Vascular/heart problems diagnosed by doctor 1.6 4.5 6.3 -1.5 -2.5 -1.7 2.5
Cholesterol lowering medication 0.8 1.2 2.0 -1.4 0.9 0.9 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 0.2 -0.2 -0.6 0.2
Pain experienced in last month 0.7 1.2 1.8 0.4 -1.4 -1.1 1.3
Supplements: Calcium 0.6 0.6 1.7 -1.3 0.2 0.8 -0.3
Basal cell carcinoma (self-reported) 1.0 1.2 2.2 -0.9 -0.9 -1.5 1.0
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 -0.2 0.3 0.0 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.6 -1.3 0.9 0.6 -0.9
Heart disease (siblings) 1.0 1.2 1.7 0.7 1.3 1.0 -1.2
Alcohol drinker status: Previous 3.2 3.7 5.9 0.9 2.4 1.7 -2.3
Pack years of smoking 0.4 0.5 1.2 0.6 -0.8 0.2 1.1
Impedance of whole body 9.7 49.5 118.8 -10.9 -5.5 -4.6 5.2
Leg fat mass (left) 10.5 40.9 92.7 9.6 4.7 5.2 -4.7
Arm predicted mass (left) 14.3 72.7 166.4 12.9 6.6 6.3 -6.5