TWAS hub - TMEM219

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0970	0.0400	1.8e-06	0.047	NA	0.063	NA	0.055	0.00018	NA	1.6e-05	NA	6.1e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0341	0.0175	2.0e-04	0.006	0.021	0.017	0.029	0.012	0.05100	0.00088	2.3e-03	9.8e-05	8.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist circumference	23.6	86.5	136.9	-11.7	-6.0
Weight	23.0	113.2	176.9	-13.3	-7.0
Basal metabolic rate	21.7	120.1	185.0	-13.6	-7.4
Leg fat-free mass (right)	21.2	113.2	176.9	-13.3	-7.0
Leg predicted mass (left)	20.9	110.6	171.6	-13.1	-7.0
Leg predicted mass (right)	20.9	111.6	174.2	-13.2	-7.0
Leg fat-free mass (left)	20.8	110.2	171.6	-13.1	-7.0
Arm fat mass (left)	20.2	82.8	130.0	-11.4	-6.0
Arm fat mass (right)	20.1	82.8	130.0	-11.4	-6.0
Hip circumference	20.0	86.1	136.9	-11.7	-5.9
Arm predicted mass (left)	20.0	101.6	156.2	-12.5	-6.8
Arm fat-free mass (left)	19.9	100.9	156.2	-12.5	-6.8
Whole body water mass	19.7	112.2	171.6	-13.1	-7.3
Whole body fat-free mass	19.4	110.6	169.0	-13.0	-7.2
Arm fat-free mass (right)	18.3	93.8	141.6	-11.9	-6.8
Arm predicted mass (right)	18.1	92.7	141.6	-11.9	-6.6
Body mass index (BMI)	18.0	76.5	119.8	-10.9	-5.8
Number of incorrect matches in round	17.4	28.8	46.2	6.8	3.4
Trunk fat-free mass	17.0	97.6	146.4	-12.1	-7.0
Trunk predicted mass	17.0	97.4	146.4	-12.1	-7.0
Whole body fat mass	16.1	67.1	108.2	-10.4	-5.1
BMI	15.8	91.9	144.0	-12.0	-6.3
Impedance of leg (right)	15.8	76.6	116.6	10.8	6.0
Leg fat mass (left)	15.5	60.5	96.4	-9.8	-5.0
Blood Red Count	15.1	146.1	237.2	15.4	7.4
Leg fat mass (right)	14.7	57.0	90.8	-9.5	-4.8
Impedance of leg (left)	14.5	70.5	106.1	10.3	5.9
Trunk fat mass	13.7	58.8	94.3	-9.7	-4.8
Impedance of whole body	13.7	69.8	104.0	10.2	6.0
Arm fat percentage (right)	12.5	49.1	79.0	-8.9	-4.4
Arm fat percentage (left)	12.0	48.0	76.9	-8.8	-4.4
Bipolar Disorder or Schizophrenia	9.7	23.6	31.9	5.6	3.9
Impedance of arm (left)	9.6	44.5	67.2	8.2	4.7
Mean Putamen Volume	9.3	10.6	20.9	-0.6	-4.6
Impedance of arm (right)	8.7	40.6	59.4	7.7	4.7
Alcohol intake frequency.	7.9	18.4	31.4	-5.6	-2.3
Schizophrenia (2018)	7.7	16.1	21.9	4.7	3.2
Body fat percentage	7.7	30.4	50.6	-7.1	-3.2
Age when periods started (menarche)	7.2	17.4	28.0	5.3	2.6
Schizophrenia (2014)	7.1	15.7	24.6	5.0	2.6
Comparative body size at age 10	7.0	19.3	27.4	-5.2	-3.4
Trunk fat percentage	6.8	27.3	45.0	-6.7	-3.1
Nervous feelings	6.8	12.6	20.5	4.5	2.2
Medication: Bendroflumethiazide	6.6	10.0	17.7	-4.2	-1.5
Alcohol intake versus 10 years previously	6.5	9.7	17.8	-4.2	-1.3
Leg fat percentage (left)	6.5	23.5	38.4	-6.2	-2.9
Alzheimer’s Disease (including proxy)	6.4	9.3	10.0	3.2	2.9
Medication: Ibuprofen (e.g. Nurofen)	6.4	8.1	10.9	-3.3	-2.3
Qualifications: NVQ or HND or HNC or equivalent	6.4	7.7	12.2	-3.5	-1.8
Blood Eosinophil Count	6.2	47.6	85.6	9.2	3.1
Neck or shoulder pain in last month	5.8	8.3	14.3	-3.8	-1.5
Comparative height size at age 10	5.7	31.4	47.2	-6.9	-4.0
Alzheimer’s Disease (in mother)	5.6	6.6	8.4	2.9	2.2
Hand grip strength (left)	5.5	14.6	23.6	-4.9	-2.4
Wheeze or whistling in the chest in last year	5.4	9.7	16.0	-4.0	-1.8
Leg fat percentage (right)	5.1	18.5	30.2	-5.5	-2.6
Bipolar Disorder (2018)	5.0	7.9	10.3	3.2	2.3
Diabetes (father)	5.0	6.2	12.1	-3.5	-0.6
High blood pressure (mother)	4.5	6.3	10.1	-3.2	-1.6
Pain all over the body in last month	4.3	4.6	8.0	-2.8	-1.1
Ever unenthusiastic/disinterested for a whole week	4.0	4.9	9.1	3.0	0.8
Eye problems/disorders: Cataract	4.0	4.7	6.8	2.6	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	13.3	3.6	1.9
LDL Cholesterol	3.9	6.2	9.5	1.7	-3.1
Height	3.6	68.8	112.4	-10.6	-5.0
Diabetes (mother)	3.6	4.6	5.6	-2.4	-1.9
Body Mass Index (BMI) (2010)	3.5	4.9	9.6	-3.1	-0.4
Fed-up feelings	3.5	6.4	11.0	-3.3	-1.4
Medication: Blood pressure	3.5	6.2	11.9	-3.5	-0.6
Chronotype (morning person)	3.4	7.9	14.7	-3.8	-1.0
Mouth/teeth dental problems: Dentures	3.4	5.8	8.4	-2.9	-1.8
Tense / ‘highly strung’	3.4	5.7	9.7	3.1	1.3
Number of children fathered	3.4	3.8	7.0	-2.6	-0.8
Asthma (self-reported)	3.4	6.8	9.5	-3.1	-2.0
Worry (Nagel 2018)	3.3	7.0	11.8	3.4	1.5
Hand grip strength (right)	3.3	8.9	14.7	-3.8	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.2	7.1	2.7	1.2
Medication: Ibuprofen	3.3	4.0	5.2	-2.3	-1.7
Type 2 Diabetes (T2D) (2018)	3.2	6.1	9.5	-3.1	-1.6
High blood pressure	3.2	8.9	16.1	-4.0	-1.3
Asthma	3.1	6.0	9.1	-3.0	-1.7
Standing height	3.1	30.9	47.5	-6.9	-3.8
Hypertension (Self-reported)	3.1	8.6	16.2	-4.0	-1.1
Basal cell carcinoma (self-reported)	3.1	3.7	7.2	2.7	0.5
Average weekly fortified wine intake	3.0	3.6	5.8	2.4	1.2
Qualifications: College or University degree	3.0	9.5	17.9	4.2	1.1
Mouth/teeth dental problems	2.7	4.1	5.7	2.4	1.6
Pulse rate	2.7	4.5	5.2	2.0	2.3
Supplements: Glucosamine	2.6	3.4	5.2	-2.3	-1.3
Vascular/heart problems diagnosed by doctor	2.6	7.1	13.0	3.6	1.1
Number of live births	2.5	3.5	4.6	2.2	1.5
Lung FEV1/FVC ratio	2.4	12.1	21.9	4.7	1.5
Triglycerides	2.2	3.6	3.8	-1.9	-1.9
Cardiovascular Disease	2.2	7.1	12.7	-3.6	-1.2
Relative age of first facial hair	2.2	4.4	6.4	2.5	1.6
Ever highly irritable/argumentative for 2 days	2.2	2.6	4.6	-2.1	-0.8
Miserableness	2.2	3.8	7.2	-2.7	-0.7
Heel T-Score	2.1	16.9	27.4	5.2	2.5
Multivitamins +/- minerals	2.1	2.7	4.7	-2.2	-0.8
Family relationship satisfaction	2.1	2.6	3.2	1.8	1.4
Happiness	2.0	2.5	3.3	1.8	1.3
Suffer from ‘nerves’	2.0	3.1	5.0	2.2	1.1
Diabetes diagnosed by doctor	2.0	3.2	5.6	-2.4	-1.0
Medication: Blood pressure	2.0	3.8	7.2	-2.7	-0.7
Ever depressed for a whole week	2.0	2.4	4.2	2.1	0.8
Respiratory disease	1.9	4.2	4.4	-2.1	-2.0
Medication: Metformin	1.9	2.6	4.9	-2.2	-0.6
Illnesses of mother	1.9	2.4	3.1	1.8	1.3
Medication for pain relief, constipation, heartburn	1.9	3.3	5.0	2.2	1.3
Wears glasses or contact lenses	1.9	2.2	3.7	-1.9	-0.8
Major Depression (MDD)	1.8	2.2	3.2	1.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	5.1	-2.2	-1.6
Schizophrenia vs Biploar Disorder	1.7	2.2	4.4	0.2	-2.1
Primary Biliary Cirrhosis	1.7	2.4	3.3	-1.8	-1.2
Angina	1.7	2.2	4.2	-2.0	-0.5
Heart disease (mother)	1.7	2.1	2.4	-1.5	-1.4
Guilty feelings	1.7	2.6	3.3	-1.8	-1.4
Fasting Glucose	1.6	1.9	2.2	1.5	1.2
Number of treatments/medications taken	1.6	3.0	4.8	-2.2	-1.0
Medication: Ramipril	1.6	2.1	3.2	-1.8	-1.0
Glaucoma (self-reported)	1.6	1.8	2.1	-1.5	-1.3
Illnesses of siblings: Diabetes	1.6	1.9	2.1	-1.4	-1.4
Medication: Gliclazide	1.6	1.8	3.4	-1.8	-0.5
Eye problems/disorders: Glaucoma	1.6	1.9	2.1	-1.3	-1.5
Medication: Lisinopril	1.6	2.1	4.1	-2.0	-0.1
HbA1C	1.5	1.7	3.2	-0.4	1.8
Blood White Count	1.5	11.3	16.2	4.0	2.5
Relative age voice broke	1.5	2.3	3.7	1.9	1.0
Illnesses of father: High blood pressure	1.5	1.9	3.8	-1.9	-0.2
Depressed Affect (Nagel 2018)	1.4	3.0	5.4	-2.3	-0.7
Diabetes (self-reported)	1.4	2.1	3.4	-1.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.9	1.7	1.1
Medication: Paracetamol	1.4	2.3	3.1	-1.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.2	1.8	0.2
Qualifications: CSEs or equivalent	1.3	1.7	2.6	-1.6	-0.9
Forced vital capacity (FVC)	1.3	5.0	8.4	-2.9	-1.3
Birth weight	1.3	2.9	4.3	-1.2	-2.1
Angina (self-reported)	1.3	1.7	3.4	-1.9	-0.3
Supplements: Vitamin C	1.3	1.5	2.4	1.5	0.9
Loneliness, isolation	1.3	1.8	2.8	-1.7	-0.8
Ever taken oral contraceptive pill	1.3	1.4	1.6	-1.2	-1.1
Smoking Status	1.2	3.0	4.5	-2.1	-1.2
Systolic blood pressure, automated reading	1.2	3.4	6.2	-2.5	-0.8
Past tobacco smoking	1.2	2.2	2.9	1.7	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.9	1.7	1.0
Worrier / anxious feelings	1.2	2.3	3.7	1.9	1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.6	3.7	1.9	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.8	1.4	1.0
Medication: Seretide 50 evohaler	1.2	1.3	2.2	-0.7	-1.5
Tinnitus: Yes, now most or all of the time	1.2	1.3	2.4	1.6	0.5
Number of operations (self-reported)	1.2	1.8	2.0	-1.3	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.8	1.7	0.6
Pulse wave reflection index	1.1	1.3	2.2	-1.5	-0.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.3	1.2	1.1
Medication: Co-codamol	1.0	1.2	1.5	-1.2	-0.9
Ever smoked	1.0	1.7	1.8	-1.3	-1.3
Systolic Blood Pressure	0.9	4.5	8.6	-2.9	-0.6
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.5	-0.9	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.7	-1.3	-0.8
Time employed in main current job	0.9	1.0	1.5	1.2	0.7
Hair/balding pattern: Pattern 3	0.9	1.3	1.7	1.3	1.0
Rheumatoid Arthritis	0.8	1.1	1.3	-1.1	-0.9
Taking other prescription medications	0.8	1.3	2.0	-1.4	-0.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.6	1.3	0.6
Long-standing illness, disability or infirmity	0.8	1.2	1.3	-1.0	-1.2
Mineral and other dietary supplements	0.8	1.0	2.0	1.4	0.3
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	1.4	-0.4
Mother’s age at death	0.8	1.0	1.3	1.2	-0.8
Myopia	0.8	1.1	1.7	1.3	-0.7
Supplements: Calcium	0.8	0.9	1.7	1.3	0.3
Alcohol drinker status: Previous	0.8	0.9	1.5	-1.2	-0.6
Blood Platelet Count	0.7	7.9	12.1	3.5	1.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	1.2	0.1
Medication for hormone replacement therapy	0.7	0.8	1.5	1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	0.8	-0.9	-0.8
Birth weight of first child	0.7	1.3	2.4	-1.6	-0.3
Blood clot in the leg (DVT)	0.7	0.9	1.6	1.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-0.7	-1.2
Neuroticism (2016)	0.6	0.9	1.1	-0.8	1.1
Serious illness, injury or assault to yourself	0.6	0.7	1.4	-1.2	-0.2
Hearing difficulty/problems with background noise	0.6	1.0	1.7	1.3	0.6
Father’s age at death	0.6	0.8	0.8	0.9	-0.8
Mean time to correctly identify matches	0.6	1.1	1.3	1.1	1.0
Leg pain on walking	0.6	0.7	0.7	-0.8	-0.8
Average weekly red wine intake	0.6	0.8	1.6	1.3	0.1
Diastolic blood pressure, automated reading	0.6	1.8	3.5	-1.9	-0.4
Ovarian Cancer	0.5	0.6	1.0	0.5	1.0
Prostate Cancer	0.5	0.8	1.1	1.1	0.6
Waist Hip Ratio (WHR)	0.5	2.3	4.4	-2.1	-0.4
Current tobacco smoking	0.5	0.8	1.6	-1.3	-0.3
Sitting height	0.5	3.3	4.5	-2.1	-1.4
Alcohol usually taken with meals	0.5	0.8	1.5	-0.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-1.1	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.4	-1.5	-0.9
Exposure to tobacco smoke at home	0.5	0.6	1.0	-1.0	-0.4
Emphysema/chronic bronchitis	0.5	0.6	0.8	-0.6	-0.9
Age at last live birth	0.5	0.7	1.5	1.2	-0.1
Medication: Aspirin	0.5	0.6	0.7	0.8	0.8
Smoking status: Previous	0.5	0.8	1.1	-1.1	-0.7
Friendships satisfaction	0.5	0.7	0.7	0.9	0.8
Hearing aid user	0.5	0.6	1.0	-1.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	-1.2	-0.2
Medication: Paracetamol	0.5	0.7	1.0	-0.7	-1.0
Irritability	0.5	0.9	1.8	-1.3	-0.1
Heart disease (siblings)	0.5	0.7	1.2	-1.1	-0.3
Neuroticism (Nagel 2018)	0.4	0.9	1.9	0.0	-1.4
Alzheimer’s Disease (in father)	0.4	0.5	0.9	1.0	0.2
Lupus	0.4	0.6	0.8	0.6	0.9
Allergy or Eczema	0.4	1.1	1.8	1.4	0.6
Severe depression (siblings)	0.4	0.5	0.5	-0.6	0.7
Maternal smoking around birth	0.4	0.5	1.1	-1.0	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	1.0	-0.2
Illnesses of siblings	0.4	0.5	0.9	0.9	0.4
Depression (self-reported)	0.4	0.5	0.7	0.9	-0.4
Prospective memory result	0.4	0.6	0.7	0.9	0.6
Forced vital capacity (FVC), Best measure	0.4	1.3	2.5	-1.6	-0.5
Pulse rate, automated reading	0.4	1.2	1.6	0.9	1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-1.0	0.3
Medication for cholesterol	0.4	0.6	1.1	1.1	0.3
Medication: Aspirin	0.4	0.5	0.7	0.6	0.8
Smoking status: Current	0.4	0.7	1.3	-1.1	-0.2
Alcohol drinker status: Never	0.4	0.5	0.7	-0.8	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.1	1.0
Pain experienced in last month	0.4	0.7	1.4	1.2	0.2
Crohns Disease (2017)	0.3	0.7	1.2	1.1	-0.4
Crohns Disease (2012)	0.3	0.4	0.7	0.8	-0.4
Lung FVC	0.3	1.7	2.0	1.4	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.7	0.8	0.6
Breastfed as a baby	0.3	0.4	0.6	0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.7	-0.3
Migraine (self-reported)	0.3	0.4	0.8	0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	-0.9	-0.1
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	0.7
Mood swings	0.3	0.6	1.2	-1.1	-0.2
Commuting to job workplace: Walk	0.3	0.4	0.7	0.8	0.2
Osteoporosis (self-reported)	0.3	0.4	0.4	-0.7	-0.5
Osteoarthritis (self-reported)	0.3	0.3	0.6	-0.3	-0.8
Average weekly beer plus cider intake	0.3	0.4	0.4	0.6	0.6
Unable to work because of sickness or disability	0.3	0.3	0.4	-0.7	-0.5
Cholesterol lowering medication	0.3	0.4	0.4	0.7	0.6
Pack years of smoking	0.3	0.5	0.9	0.9	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-1.1	-0.4
Reaction Time	0.2	0.4	0.7	0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.4	-0.7	-0.6
Hypothyroidism (self reported)	0.2	0.5	0.9	0.4	0.9
Neuroticism	0.2	0.5	0.9	-0.9	-0.5
Tanning	0.2	2.9	5.2	2.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.6	-0.2
Pack years adult smoking proportion	0.2	0.3	0.5	0.7	0.2
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.7	0.1
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.8	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.7	0.1
Medication: Atenolol	0.2	0.2	0.3	-0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.6	0.7	0.8
Qualifications: None of the above	0.2	0.4	0.8	-0.9	0.2
Fluid intelligence score	0.2	0.4	0.5	-0.6	-0.7
Neuroticism score	0.2	0.5	0.8	-0.9	-0.4
Falls in the last year	0.2	0.3	0.6	-0.8	0.1
Medication: Lansoprazole	0.2	0.2	0.4	-0.6	-0.3
Lung cancer (father)	0.2	0.2	0.5	0.0	-0.7
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.7	-0.0
Length of working week for main job	0.2	0.2	0.4	-0.1	-0.7
Peak expiratory flow (PEF)	0.2	0.4	0.4	-0.6	-0.6
Headache pain in last month	0.2	0.3	0.3	-0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	-0.7	-0.3
High blood pressure (siblings)	0.2	0.4	0.6	-0.8	-0.3
Exposure to tobacco smoke outside home	0.2	0.3	0.5	0.7	-0.0
Worry too long after embarrassment	0.2	0.4	0.8	0.9	0.1
Number of full sisters	0.2	0.2	0.3	-0.6	-0.2
Knee pain experienced in last month	0.2	0.2	0.3	-0.4	-0.5
Qualifications: nursing, teaching	0.2	0.4	0.7	0.2	0.8
Breast cancer (self-reported)	0.2	0.3	0.3	-0.6	-0.5
Medication: Atorvastatin	0.2	0.3	0.6	0.2	0.8
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.6	0.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.3	0.4
HDL Cholesterol	0.1	0.2	0.2	0.4	-0.3
Ulcerative Colitis	0.1	0.2	0.2	-0.5	0.3
Average weekly spirits intake	0.1	0.2	0.4	0.6	0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.2	-0.4
Vitamin and mineral supplements	0.1	0.2	0.3	0.6	-0.2
Supplements: Zinc	0.1	0.2	0.2	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.2	-0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.3	0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.2	0.4	0.5
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	-0.2
Heart attack	0.1	0.1	0.2	0.2	0.5
Allergy	0.1	0.1	0.2	0.1	0.5
Medication: Simvastatin	0.1	0.2	0.3	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.6	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.6	0.4
Medication: Amlodipine	0.1	0.2	0.4	-0.6	-0.1
Health satisfaction	0.1	0.1	0.2	-0.4	0.2
Had major operations	0.1	0.1	0.2	0.5	-0.1
Ever had bowel cancer screening	0.1	0.1	0.1	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.5	-0.2
Back pain experienced in last month	0.1	0.1	0.2	-0.0	-0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.6	0.1
Financial situation satisfaction	0.1	0.2	0.3	0.1	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	0.6	-0.1
High cholesterol (Self-reported)	0.1	0.1	0.2	0.4	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.3	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.2	0.5
Breast Cancer	0.0	0.0	0.0	0.1	0.2
Age at First Birth	0.0	0.1	0.1	0.2	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.3	0.3	0.6	0.4
Sensitivity / hurt feelings	0.0	0.0	0.0	-0.1	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.0	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.1	-0.4
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.0	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.2	-0.0
Had menopause	0.0	0.0	0.0	0.2	0.1
Had other major operations	0.0	0.0	0.1	-0.3	-0.1
Noisy workplace	0.0	0.1	0.1	0.2	0.2
Medication: Cholesterol lowering	0.0	0.0	0.1	0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.4	0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.2	-0.2
Loud music exposure frequency	0.0	0.0	0.0	-0.2	0.1
Gout (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Number of full brothers	0.0	0.0	0.0	-0.1	-0.1
Age at first live birth	0.0	0.0	0.1	-0.1	-0.3
Pulse wave peak to peak time	0.0	0.0	0.0	0.2	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.0	0.0	0.1
Eye problems/disorders: None of the above	0.0	0.1	0.1	-0.3	-0.2
Medication: Allopurinol	0.0	0.0	0.0	-0.1	0.1
Medication: Omeprazole	0.0	0.0	0.0	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.1	-0.3
Overall health rating	0.0	0.1	0.1	-0.2	-0.4
Chest pain or discomfort	0.0	0.0	0.1	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.2	-0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.2	-0.3
Risk taking	0.0	0.0	0.0	-0.2	-0.2
Age started oral contraceptive pill	0.0	0.0	0.1	-0.0	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	0.3	0.1

Hub : Genes

TMEM219

Models

Trait associations