Hub : Genes

MCHR1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1530 0.0420 2.4e-14 0.069 0.128 0.135 0.126 0.141 8.6e-09 2.5e-15 4.6e-16 4.4e-15 7.5e-17
2 NTR Blood 0.1079 0.0310 8.3e-16 0.063 0.057 0.074 0.068 0.069 1.2e-19 6.5e-18 1.0e-22 4.7e-21 2.3e-21
3 TCGA Breast Invasive Carcinoma 0.0295 0.0165 5.0e-05 0.024 0.022 0.020 NA 0.021 9.5e-06 1.9e-05 4.8e-05 NA 2.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 12.5 19.8 32.7 -5.7 4.8 1.8
Bipolar Disorder or Schizophrenia 9.9 24.0 44.0 -6.6 4.5 2.9
Depressed Affect (Nagel 2018) 0.5 1.1 3.0 -0.5 0.5 -1.7
Depression (Nagel 2018) 1.2 1.8 4.0 -1.3 2.0 0.1
Intelligence (Savage-Jansen 2018) 1.6 4.8 7.3 1.1 -2.4 -2.7
Neuroticism (Nagel 2018) 1.7 4.0 6.5 -2.2 2.6 -0.9
Schizophrenia (2018) 3.7 7.6 15.2 -3.9 1.8 2.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.5 0.5 -0.7 0.2
Worry (Nagel 2018) 4.0 8.4 15.4 -3.1 3.9 0.6
Alzheimer’s Disease (in mother) 1.0 1.2 1.8 -1.3 1.3 -0.5
Alzheimer’s Disease (in father) 0.5 0.5 1.3 -0.5 1.1 0.2
Alzheimer’s Disease (including proxy) 2.0 2.8 5.1 -1.8 2.3 -0.2
Crohns Disease (2017) 1.0 2.2 4.1 -1.5 2.0 0.3
Irritable Bowel Disease (IBD) 0.8 1.8 3.2 -1.4 1.8 -0.6
Ulcerative Colitis (UC) 0.4 0.8 1.4 -0.4 1.0 -1.2
Major Depression (MDD) 2.0 2.4 5.1 -1.3 2.3 0.7
Reaction Time 0.3 0.5 1.4 0.3 0.2 1.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.6 0.6 -0.4 -1.3
Breast Cancer 4.8 11.6 34.5 -5.9 -0.1 0.6
Ovarian Cancer 0.1 0.1 0.4 0.1 -0.0 0.6
Prostate Cancer 0.0 0.0 0.1 0.3 0.1 0.1
Age at First Birth 3.3 4.7 10.2 -3.2 1.8 0.8
Bipolar Disorder (2011) 3.3 3.2 7.1 -2.7 1.5 0.3
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.5 -0.8 0.4
Coronary Artery Disease (CAD) 0.9 1.1 2.6 1.6 -0.8 -0.3
Crohns Disease (2012) 1.5 2.4 4.4 -1.4 2.1 1.0
Mean Putamen Volume 0.3 0.4 0.7 -0.8 0.1 -0.6
Fasting Glucose 2.0 2.4 4.0 1.6 -0.8 -2.0
HbA1C 0.3 0.4 0.6 0.1 -0.8 -0.7
HDL Cholesterol 0.0 0.1 0.1 -0.0 -0.2 0.4
LDL Cholesterol 0.3 0.5 1.3 0.2 -1.1 0.4
Lupus 0.0 0.0 0.1 0.0 -0.3 -0.2
Neuroticism (2016) 1.1 1.6 2.3 -1.5 1.2 -1.0
Primary Biliary Cirrhosis 0.2 0.2 0.4 0.4 0.3 -0.6
Rheumatoid Arthritis 3.9 5.4 10.9 3.3 -2.1 -0.9
Schizophrenia (2014) 4.9 10.7 21.8 -4.7 2.4 2.2
Triglycerides 0.1 0.1 0.2 0.1 0.4 -0.4
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.7 0.6 -0.3 1.6
Ulcerative Colitis 0.2 0.3 0.5 -0.3 0.7 -0.7
Blood Eosinophil Count 1.7 12.9 14.6 -3.5 3.8 -3.5
Blood Platelet Count 0.3 3.6 9.4 -3.1 1.2 -0.3
Blood Red Count 0.4 4.1 10.0 0.8 1.3 -3.2
Blood White Count 0.4 2.7 7.2 0.1 -2.7 0.9
Heel T-Score 1.0 7.7 15.5 0.9 2.6 -3.9
BMI 1.1 6.2 16.0 1.3 -4.0 1.0
Height 0.4 8.6 20.3 -1.2 2.0 -4.5
Waist Hip Ratio (WHR) 1.7 7.5 13.5 3.7 -2.8 -1.2
Systolic Blood Pressure 0.4 2.1 3.0 1.7 -1.5 0.9
Smoking Status 0.3 0.8 1.5 1.2 -0.3 0.8
Allergy or Eczema 1.1 3.0 4.5 -2.1 2.1 0.2
Cardiovascular Disease 0.6 2.0 3.7 -0.2 -1.5 1.9
Hypothyroidism (self reported) 0.3 0.8 1.8 -0.7 1.3 -0.3
Respiratory disease 3.1 7.0 11.4 3.4 -1.5 -2.7
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.5 1.2 -1.1 -0.1
Lung FEV1/FVC ratio 1.6 8.0 18.9 -4.3 -0.4 2.2
Lung FVC 0.2 1.2 3.4 -1.9 0.5 -0.1
Neuroticism 1.8 4.3 6.6 -2.0 2.6 -1.6
Chronotype (morning person) 1.4 3.2 8.9 0.7 -3.0 0.2
Hair Pigment 0.2 6.2 14.7 3.8 -0.9 -1.8
Tanning 0.3 3.6 4.8 2.2 -1.7 -1.7
Hand grip strength (left) 0.4 1.0 3.0 0.1 -1.7 -0.3
Number of treatments/medications taken 0.0 0.0 0.1 0.0 0.3 -0.2
Average weekly spirits intake 0.3 0.4 0.7 0.9 0.0 -0.6
Sensitivity / hurt feelings 0.4 0.7 1.5 -0.0 1.2 -0.7
Frequency of depressed mood in last 2 weeks 1.9 2.7 5.8 -1.5 2.4 0.4
Hearing difficulty/problems: Yes 0.3 0.4 0.8 0.9 0.6 0.2
Relative age of first facial hair 1.7 3.6 7.2 1.4 -1.3 -2.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 0.9 -0.4 0.4
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.4 1.2 -1.1 0.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.9 0.9 0.1 -0.1
Systolic blood pressure, automated reading 1.4 4.0 6.8 2.1 -2.6 0.7
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.4 -1.9 0.6 0.9
Angina 1.7 2.2 6.4 0.6 0.0 -2.5
Medication for hormone replacement therapy 1.0 1.1 1.6 1.3 -0.9 0.9
Vitamin and mineral supplements 0.8 1.0 1.7 0.2 -1.3 1.1
Supplements: Zinc 0.1 0.1 0.2 -0.3 -0.3 0.5
Medication: Co-codamol 1.4 1.7 3.7 -1.9 0.9 -0.8
Medication: Metformin 0.7 1.0 1.5 1.1 -1.2 0.5
Diabetes (father) 0.2 0.2 0.3 0.5 -0.5 -0.4
Diabetes (mother) 4.0 5.1 7.5 2.4 -1.5 2.7
Severe depression (siblings) 0.4 0.4 1.1 -1.1 -0.2 -0.3
Pack years adult smoking proportion 1.5 2.3 3.6 1.9 -0.9 1.6
Impedance of leg (right) 1.5 7.4 13.8 1.3 2.6 -3.7
Leg fat-free mass (left) 0.4 2.2 5.3 -2.3 -0.0 1.2
Trunk fat percentage 0.3 1.2 2.0 0.9 -0.9 -1.4
Hand grip strength (right) 0.1 0.3 0.6 -0.5 -0.8 -0.0
Townsend deprivation index at recruitment 0.4 0.5 1.3 -0.5 -0.1 1.2
Current tobacco smoking 0.3 0.5 1.0 1.0 -0.1 0.7
Average weekly fortified wine intake 0.3 0.4 0.8 0.5 -0.2 -0.9
Maternal smoking around birth 1.2 1.7 2.9 1.5 -1.7 0.1
Fed-up feelings 0.8 1.4 2.3 -1.5 0.8 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 1.7 -1.3 1.3 0.0
Relative age voice broke 0.3 0.5 1.0 0.6 -0.2 -1.0
Taking other prescription medications 0.1 0.1 0.3 -0.4 0.5 -0.0
Age when periods started (menarche) 3.6 8.7 15.2 -2.5 3.9 2.1
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 5.3 2.3 -1.3 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 4.0 0.3 1.5 -2.0
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.7 -0.2 0.4 1.9
Qualifications: CSEs or equivalent 3.6 4.7 9.3 3.1 -2.2 -0.2
Serious illness, injury or assault to yourself 0.7 0.9 2.0 -0.2 1.4 0.8
High blood pressure 0.4 1.2 2.1 -0.9 -0.8 1.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.6 -1.2 1.3 0.1
Multivitamins +/- minerals 0.9 1.2 3.1 0.1 0.6 -1.8
Stomach or abdominal pain in last month 1.2 1.6 3.5 -0.8 1.9 -0.7
Supplements: Glucosamine 1.6 2.0 4.3 2.1 -1.2 -0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.5 1.0 0.0 -1.2
Medication: Atenolol 1.6 2.0 3.5 1.0 -1.3 -1.9
Medication: Levothyroxine sodium 0.5 0.8 1.3 -0.3 1.1 1.0
Sitting height 0.5 3.4 4.9 -2.0 1.1 -2.2
Chronic bronchitis/emphysema (father) 0.8 1.0 2.2 1.5 -0.3 -0.8
High blood pressure (mother) 1.0 1.4 2.1 0.9 -1.4 1.1
Body mass index (BMI) 0.8 3.6 8.8 0.2 -3.0 1.4
Impedance of leg (left) 1.5 7.2 13.2 1.1 2.7 -3.6
Leg predicted mass (left) 0.4 2.0 4.9 -2.2 -0.1 1.0
Trunk fat mass 0.1 0.5 0.9 -0.0 -0.8 -0.9
Waist circumference 0.7 2.4 6.4 0.7 -2.5 0.6
Number of incorrect matches in round 2.2 3.6 5.8 -2.4 1.8 1.3
Past tobacco smoking 1.3 2.4 4.7 -2.2 1.5 0.4
Alcohol usually taken with meals 0.3 0.5 0.8 -0.9 0.6 -0.5
Nervous feelings 2.0 3.7 6.2 -2.2 2.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 8.5 -0.8 2.9 -0.1
Hearing difficulty/problems with background noise 0.9 1.4 2.3 1.5 -0.4 1.4
Hair/balding pattern: Pattern 2 0.4 0.5 1.5 0.0 -0.4 -1.2
Had menopause 1.0 1.3 1.7 1.3 -1.3 -0.7
Had other major operations 0.5 0.7 1.2 0.8 0.4 -1.1
Forced vital capacity (FVC) 0.9 3.4 5.2 -2.3 1.6 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 2.6 0.3 1.6 -1.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.1 1.0 -0.4 -1.1
Qualifications: None of the above 1.3 2.7 4.1 1.6 -1.1 2.0
Financial difficulties in last 2 years 0.2 0.3 0.4 0.4 -0.7 0.4
Mouth/teeth dental problems 0.6 0.9 2.1 -0.8 -0.1 1.5
Heart attack 1.3 1.6 4.1 -0.8 0.2 -2.0
Allergy 0.2 0.4 0.7 -0.0 -0.8 0.8
Pain all over the body in last month 0.4 0.5 0.6 0.7 0.6 -0.7
Diabetes (self-reported) 0.8 1.3 2.2 0.7 -1.0 1.5
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 1.9 1.4 -1.3 -0.0
Medication: Ramipril 0.0 0.0 0.1 -0.3 0.0 -0.2
Medication: Simvastatin 1.5 2.2 6.0 0.8 -2.5 -0.1
Fluid intelligence score 0.3 0.6 1.0 -0.0 -1.0 -0.9
Illnesses of siblings 0.3 0.4 1.3 -0.1 1.1 0.1
Neuroticism score 1.4 2.9 5.1 -1.8 2.3 -0.6
Weight 0.2 0.9 1.5 -1.2 -1.1 0.2
Impedance of arm (right) 1.7 8.1 14.9 2.3 2.1 -3.9
Arm fat percentage (right) 0.5 1.8 4.2 1.0 -2.0 -0.4
Trunk fat-free mass 0.6 3.2 8.8 -3.0 0.0 0.8
Hip circumference 0.2 0.9 1.7 -1.3 -0.1 1.0
Time employed in main current job 7.5 8.7 11.6 -3.4 1.8 3.3
Alcohol intake versus 10 years previously 0.9 1.4 1.6 1.1 -1.2 -1.3
Father’s age at death 0.2 0.2 0.5 0.7 -0.3 0.2
Worrier / anxious feelings 0.9 1.7 2.2 -1.4 1.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 3.1 -1.1 1.8 -0.2
Falls in the last year 1.1 1.5 2.7 1.6 0.2 -1.3
Hair/balding pattern: Pattern 3 1.6 2.4 2.9 -1.3 1.6 1.7
Number of live births 4.7 6.7 8.8 3.0 -2.8 -1.9
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 7.7 -2.8 1.1 -1.2
Pulse rate 2.6 4.3 6.8 -2.6 1.2 2.2
Happiness 2.6 3.1 5.1 -1.9 2.3 0.9
Noisy workplace 1.0 1.2 3.0 0.8 0.3 1.7
Qualifications: A levels/AS levels or equivalent 1.5 3.3 4.9 -2.2 2.1 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.1 1.5 0.5 -0.8
Mouth/teeth dental problems: Dentures 0.7 1.2 3.3 1.8 -0.4 -0.3
Asthma 1.3 2.6 3.8 1.9 -1.4 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.8 -0.6 1.7 0.4
Medication: Cholesterol lowering 1.0 1.5 4.3 -0.2 -2.1 -0.5
Depression (self-reported) 1.6 2.0 3.0 -1.7 1.7 -0.3
Medication: Lansoprazole 0.1 0.1 0.2 0.5 0.2 -0.3
Prospective memory result 0.3 0.3 0.5 -0.3 0.6 -0.7
Lung cancer (father) 0.6 0.7 1.6 -0.4 0.5 1.3
Illnesses of mother 0.3 0.4 1.0 -0.1 1.0 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 8.6 -2.9 1.3 -0.6
Pulse wave Arterial Stiffness index 0.8 1.0 1.6 -1.1 -0.4 -1.3
Impedance of arm (left) 1.9 8.8 14.3 2.3 2.6 -3.8
Arm fat mass (right) 0.3 1.3 3.8 0.2 -1.9 -0.1
Trunk predicted mass 0.6 3.2 8.9 -3.0 0.1 0.9
Standing height 0.9 9.1 12.5 -2.6 3.5 -2.8
Length of working week for main job 0.6 0.6 1.6 0.5 -1.3 0.2
Exposure to tobacco smoke at home 2.2 2.4 3.6 -1.1 1.9 1.6
Breastfed as a baby 0.3 0.3 0.6 -0.5 0.4 -0.8
Tense / ‘highly strung’ 2.4 4.0 8.1 -2.0 2.8 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.8 1.7 -0.5 1.3 -0.8
Hair/balding pattern: Pattern 4 0.6 1.5 1.7 1.0 -1.3 1.3
Birth weight of first child 0.7 1.2 2.5 -1.6 1.0 0.3
Peak expiratory flow (PEF) 0.3 0.8 2.1 -1.4 -0.0 0.4
Pulse wave reflection index 1.0 1.3 3.0 -0.9 0.0 -1.7
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.9 0.9 0.4 -0.5
Loud music exposure frequency 1.6 1.7 4.3 -0.4 2.1 0.9
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.4 1.2 0.4 -0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.8 -0.8 0.2 -0.9
Blood clot in the leg (DVT) 0.0 0.1 0.1 -0.3 -0.3 0.1
Medication: Paracetamol 4.3 7.2 11.4 -2.4 3.4 2.1
Headache pain in last month 0.2 0.3 1.0 0.0 1.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.4 1.2 0.8 -0.7
Glaucoma (self-reported) 0.9 1.0 2.8 0.6 -0.2 -1.7
Gout (self-reported) 0.0 0.0 0.1 0.4 0.1 0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.2 0.4 -0.7
Medication: Amlodipine 1.1 1.5 2.9 -0.9 -0.8 1.7
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.9 0.2 -0.0 -1.0
Birth weight 2.0 4.4 6.6 -2.6 2.5 -0.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 0.9 -0.7 0.9 -0.9
High blood pressure (siblings) 0.5 0.7 1.7 -0.6 -0.1 1.3
Forced vital capacity (FVC), Best measure 0.6 2.1 3.4 -1.8 1.4 -0.9
Body fat percentage 0.2 0.8 1.4 0.6 -1.2 -0.8
Leg fat percentage (right) 0.4 1.4 3.4 0.8 -1.9 0.0
Arm fat-free mass (right) 0.7 3.6 9.1 -3.0 0.1 1.3
Exposure to tobacco smoke outside home 1.0 1.4 3.7 1.9 -0.5 0.4
Comparative body size at age 10 3.6 9.9 23.8 -2.4 -0.3 4.9
Number of full brothers 3.1 3.9 7.6 2.8 -1.4 -1.5
Worry too long after embarrassment 0.3 0.5 0.9 0.2 0.9 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.3 -0.9 1.8 0.0
Wheeze or whistling in the chest in last year 0.2 0.4 1.0 1.0 0.2 -0.2
Number of children fathered 1.6 1.8 3.4 1.4 -1.9 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 4.5 5.3 9.1 -2.2 1.4 3.0
Age at first live birth 4.0 7.1 12.8 -3.6 2.3 1.8
Pulse wave peak to peak time 0.8 0.9 1.5 0.8 0.8 1.2
Health satisfaction 0.1 0.1 0.1 0.3 0.3 0.3
Shortness of breath walking on level ground 1.0 1.2 3.4 -0.3 1.9 0.3
Qualifications: College or University degree 2.0 6.2 10.9 -3.3 2.8 -0.2
Eye problems/disorders: None of the above 1.2 1.4 3.2 1.8 -0.1 -1.0
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.4 0.6 0.6 -0.3
Emphysema/chronic bronchitis 1.0 1.1 3.2 1.8 0.2 -0.4
Medication for pain relief, constipation, heartburn 2.8 4.7 10.7 1.8 -3.3 -0.5
Neck or shoulder pain in last month 0.5 0.7 1.5 -0.1 1.2 -0.8
Medication: Blood pressure 0.7 1.2 2.1 -1.5 0.0 1.2
Angina (self-reported) 1.5 2.0 5.3 0.8 -0.1 -2.3
Migraine (self-reported) 0.2 0.3 0.8 0.0 0.4 -0.9
Medication: Ibuprofen 0.8 0.9 2.6 -0.1 1.6 -0.4
Medication: Allopurinol 0.8 1.1 3.0 0.4 0.2 -1.7
Medication: Omeprazole 0.3 0.4 0.8 0.1 0.5 -0.9
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.6 0.7 0.3
Mean time to correctly identify matches 0.5 0.9 1.9 0.9 -0.1 1.4
Heart disease (mother) 0.6 0.7 1.9 -0.4 -1.4 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.8 4.5 5.6 2.3 -1.6 -2.4
Whole body fat mass 0.1 0.5 1.4 -0.1 -1.2 -0.3
Leg fat mass (right) 0.2 0.8 2.1 -0.1 -1.5 0.5
Arm predicted mass (right) 0.8 4.0 9.6 -3.1 0.2 1.5
Pulse rate, automated reading 2.0 6.5 10.4 -3.2 2.3 1.9
Alcohol intake frequency. 0.5 1.2 2.1 -1.1 1.5 0.6
Comparative height size at age 10 0.5 2.6 7.4 0.4 0.6 -2.7
Number of full sisters 0.7 0.8 2.2 1.5 -0.4 0.2
Suffer from ‘nerves’ 0.7 1.2 3.3 -0.4 1.8 0.3
Overall health rating 0.2 0.5 0.9 0.7 -0.2 -1.0
Chest pain or discomfort 1.1 1.6 3.0 -1.1 1.7 -0.8
Had major operations 2.0 2.4 4.0 1.6 -2.0 -0.8
Age at last live birth 2.0 2.9 6.4 -2.5 1.4 -0.5
Family relationship satisfaction 1.8 2.2 3.4 -1.9 1.7 -0.5
Leg pain on walking 1.2 1.4 3.4 0.9 0.3 1.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 0.3 0.4 1.1
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.6 2.1 -0.6 -1.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.1 -0.3 -1.4 0.9
Medication: Aspirin 0.6 0.9 1.8 -0.2 0.9 -1.3
Supplements: Vitamin C 0.4 0.5 0.9 0.3 1.0 -0.6
Knee pain experienced in last month 0.9 1.5 3.8 1.9 -0.8 0.2
Hypertension (Self-reported) 0.3 0.9 1.4 -0.8 -0.8 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.9 1.7 -0.7 -0.4
Illnesses of father: Heart disease 0.7 0.9 2.5 -0.6 -0.1 -1.6
Illnesses of siblings: Diabetes 0.1 0.2 0.3 -0.4 0.5 0.2
Smoking status: Previous 1.5 2.2 3.0 1.7 -1.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 4.5 -1.6 2.1 -0.4
Whole body fat-free mass 0.6 3.2 8.6 -2.9 0.0 1.0
Leg fat-free mass (right) 0.5 2.4 6.0 -2.5 -0.0 1.1
Arm fat percentage (left) 0.3 1.3 3.1 0.9 -1.8 -0.1
Average weekly red wine intake 0.0 0.0 0.0 -0.2 0.1 -0.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.3 -1.5 -0.2 1.2
Mood swings 2.2 3.9 6.7 -2.6 2.2 -0.6
Loneliness, isolation 0.3 0.5 1.1 0.3 0.3 -1.1
Long-standing illness, disability or infirmity 0.2 0.2 0.6 0.0 -0.4 0.8
Ever had bowel cancer screening 1.0 1.1 1.5 -0.9 1.2 -1.0
Diabetes diagnosed by doctor 0.4 0.6 1.2 0.4 -0.7 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.2 0.6 -0.1 -1.1
Friendships satisfaction 0.2 0.2 0.5 0.2 -0.1 -0.7
Qualifications: nursing, teaching 1.0 1.5 4.2 -0.4 -0.4 -2.1
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.5 0.8 -0.0
Eye problems/disorders: Cataract 1.5 1.7 3.9 -2.0 0.9 0.6
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 4.6 -1.1 2.1 0.5
Medication for cholesterol 0.6 1.0 1.9 -0.9 1.4 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.3 -0.8 1.2 0.5
Back pain experienced in last month 0.8 1.1 1.8 -0.7 1.3 1.1
Mineral and other dietary supplements 1.4 1.9 4.1 -2.0 0.9 0.9
Breast cancer (self-reported) 5.7 6.8 17.9 4.2 -1.5 0.4
Asthma (self-reported) 1.3 2.6 3.5 1.9 -1.5 -1.4
Osteoporosis (self-reported) 0.4 0.5 1.2 -1.1 -0.1 0.4
Osteoarthritis (self-reported) 0.5 0.7 1.4 0.8 0.3 -1.2
Medication: Aspirin 0.3 0.4 1.2 0.1 0.3 -1.1
Medication: Gliclazide 0.4 0.5 0.8 -0.6 -0.6 0.9
Illnesses of father: None of the above (group 1) 0.6 0.8 2.3 -0.1 0.0 1.5
Smoking status: Current 0.4 0.6 1.5 0.2 0.4 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.8 -1.9 -0.7 -0.2
Whole body water mass 0.6 3.5 9.2 -3.0 0.1 1.1
Leg predicted mass (right) 0.4 2.3 5.6 -2.4 -0.1 1.1
Arm fat mass (left) 0.3 1.2 3.4 0.1 -1.8 0.3
Number of self-reported non-cancer illnesses 0.3 0.6 0.9 0.8 -0.5 -0.9
Average weekly champagne plus white wine intake 0.7 0.9 2.3 -0.6 1.5 -0.4
Miserableness 0.2 0.4 0.4 0.6 -0.6 -0.6
Guilty feelings 0.6 0.9 2.1 -1.5 0.7 0.3
Wears glasses or contact lenses 0.1 0.1 0.2 -0.3 -0.1 -0.4
Ever taken oral contraceptive pill 1.8 2.0 6.0 0.1 -0.3 2.4
Hearing aid user 1.7 1.9 4.2 1.1 -2.1 -0.3
Mother’s age at death 0.3 0.4 0.7 0.7 -0.8 0.3
Financial situation satisfaction 0.1 0.1 0.2 0.1 0.1 -0.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.2 0.8 0.1 -1.5
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.4 -0.2 0.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.1 0.6 0.1 -1.1
Medication: Blood pressure 0.2 0.5 0.8 -0.7 -0.3 0.9
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.7 -0.1 1.3 -0.0
Supplements: Fish oil (including cod liver oil) 2.4 3.1 5.6 2.4 -1.2 -1.5
High cholesterol (Self-reported) 1.3 2.3 6.1 0.9 -2.5 0.2
Medication: Bendroflumethiazide 0.3 0.4 0.8 -0.1 -0.7 0.9
Medication: Paracetamol 4.6 7.1 11.7 -2.2 3.4 2.1
Medication: Lisinopril 0.9 1.2 2.9 -1.7 0.5 0.6
Medication: Atorvastatin 0.4 0.5 1.0 0.6 -1.0 0.5
Illnesses of father: High blood pressure 1.3 1.6 4.1 -2.0 0.8 0.4
Alcohol drinker status: Never 2.8 3.3 6.1 -1.6 1.1 2.5
Ever smoked 3.1 5.4 9.0 3.0 -2.0 -1.8
Basal metabolic rate 0.4 2.4 6.5 -2.5 -0.1 0.9
Leg fat percentage (left) 0.4 1.3 3.3 0.8 -1.8 0.0
Arm fat-free mass (left) 0.6 3.1 7.8 -2.8 -0.3 1.1
Number of operations (self-reported) 2.0 2.9 4.4 2.1 -1.3 -1.6
Average weekly beer plus cider intake 1.0 1.4 3.4 1.8 -0.9 -0.2
Irritability 1.6 2.7 4.3 -2.1 1.9 -0.6
Risk taking 0.6 0.9 1.6 0.9 -0.4 1.3
Ever had prostate specific antigen (PSA) test 1.4 1.6 4.4 -0.6 -0.2 -2.1
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.2 -0.4 0.1
Age started oral contraceptive pill 1.2 1.5 2.7 0.9 -1.6 -1.0
Diastolic blood pressure, automated reading 0.6 1.8 3.7 -1.9 -0.8 1.0
Ever depressed for a whole week 0.4 0.5 1.2 0.2 1.1 -0.6
Unable to work because of sickness or disability 1.0 1.3 1.9 -0.4 1.4 1.3
Commuting to job workplace: Cycle 0.8 0.9 1.4 -1.1 -1.2 0.5
Myopia 0.3 0.4 1.2 -0.4 1.1 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.5 0.5 1.2 -0.8
Cholesterol lowering medication 1.6 2.4 3.7 1.7 -1.9 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 0.4 0.4 -0.8
Pain experienced in last month 0.2 0.4 0.7 -0.8 -0.6 -0.3
Supplements: Calcium 1.2 1.3 2.7 0.9 -1.7 -0.7
Basal cell carcinoma (self-reported) 1.5 1.8 3.7 -1.9 0.4 -1.2
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.9 -0.6 0.2 -2.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 -0.3 -0.2 0.5
Heart disease (siblings) 1.5 1.9 3.6 0.8 -1.9 -1.2
Alcohol drinker status: Previous 1.4 1.6 3.7 -0.4 1.9 1.0
Pack years of smoking 1.3 1.9 3.6 1.9 -0.8 1.2
Impedance of whole body 2.0 10.0 17.4 1.9 3.0 -4.2
Leg fat mass (left) 0.2 0.8 2.0 -0.1 -1.4 0.5
Arm predicted mass (left) 0.6 2.9 7.1 -2.7 -0.4 1.2