[Hub]/) : Traits : Crohns Disease (2012) : ← →

chr5:129,797,129-132,900,729

Best TWAS P=1.83e-19 · Best GWAS P=1.36e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	8.1	-9.0	1.8e-19	-0.82	0.47	0.53	TRUE
37	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	8.0	-7.9	2.2e-15	-0.78	0.46	0.20	TRUE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-6.7	-7.7	1.6e-14	-0.78	0.03	0.91	TRUE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	7.1	7.1	1.5e-12	0.65	0.19	0.77	TRUE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-6.7	-6.8	8.3e-12	-0.65	0.10	0.53	TRUE
39	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-5.3	-6.3	2.3e-10	-0.78	0.40	0.59	TRUE
78	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-5.5	5.4	7.1e-08	0.59	0.61	0.32	TRUE
26	GTEx	Lung	RAD50	0.12	0.09	lasso	11	0.08	1.3e-06	-5.3	-5.2	1.6e-07	-0.44	0.92	0.02	TRUE
61	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	8.5	-8.7	3.2e-18	-0.76	0.03	0.96	FALSE
44	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	7.7	8.5	1.6e-17	0.83	0.08	0.92	FALSE
23	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	8.0	-8.3	1.1e-16	-0.82	0.93	0.07	FALSE
2	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	8.1	-8.1	6.9e-16	-0.78	0.10	0.84	FALSE
51	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	8.0	-8.0	9.5e-16	-0.84	0.86	0.14	FALSE
56	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	8.0	-8.0	9.8e-16	-0.84	0.36	0.64	FALSE
19	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	8.0	-8.0	1.0e-15	-0.77	0.14	0.76	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	9.2	8.0	1.1e-15	0.87	0.00	0.91	FALSE
27	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	8.0	-7.9	2.1e-15	-0.84	0.64	0.36	FALSE
18	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-6.7	-7.9	2.6e-15	-0.79	1.00	0.00	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-8.0	-7.9	3.2e-15	-0.70	0.14	0.13	FALSE
40	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	7.7	-7.8	4.9e-15	-0.83	0.14	0.86	FALSE
41	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	8.1	-7.8	6.0e-15	-0.84	0.99	0.01	FALSE
48	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-4.6	-7.8	6.4e-15	-0.66	0.68	0.30	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	-5.6	7.7	1.1e-14	0.73	0.08	0.45	FALSE
6	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	7.7	7.7	1.9e-14	0.77	0.58	0.40	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	7.1	7.6	2.4e-14	0.76	0.42	0.58	FALSE
59	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-5.3	7.6	2.6e-14	0.67	0.68	0.32	FALSE
52	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	8.1	-7.6	2.8e-14	-0.77	0.17	0.82	FALSE
58	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	-8.1	-7.6	3.4e-14	-0.49	0.22	0.18	FALSE
63	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	8.0	-7.5	4.3e-14	-0.80	0.99	0.01	FALSE
50	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-6.7	-7.4	1.0e-13	-0.69	0.16	0.73	FALSE
49	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	7.2	7.4	1.2e-13	0.77	0.24	0.67	FALSE
24	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	7.7	7.3	2.1e-13	0.77	0.52	0.46	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	8.0	-7.2	4.7e-13	-0.74	0.04	0.91	FALSE
8	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	7.2	7.2	4.9e-13	0.77	0.78	0.22	FALSE
42	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	8.0	7.2	5.5e-13	0.81	0.06	0.84	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-5.3	-7.2	6.1e-13	-0.74	0.24	0.76	FALSE
7	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	7.3	7.2	8.0e-13	0.77	0.15	0.69	FALSE
46	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	7.2	7.1	1.1e-12	0.76	0.40	0.50	FALSE
11	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	7.1	7.0	1.8e-12	0.77	0.47	0.53	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	-6.9	-6.9	6.5e-12	-0.42	0.08	0.24	FALSE
55	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	6.0	-6.8	7.3e-12	-0.70	0.54	0.44	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-4.7	-6.8	1.5e-11	-0.59	0.47	0.20	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-6.7	-6.7	2.4e-11	-0.70	0.02	0.54	FALSE
32	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	-4.6	-6.6	3.6e-11	-0.43	0.76	0.20	FALSE
60	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	6.0	-6.6	4.7e-11	-0.69	0.15	0.82	FALSE
62	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-5.4	-6.6	5.2e-11	-0.78	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	8.0	-6.5	7.1e-11	-0.71	0.41	0.20	FALSE
43	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-7.6	-6.5	8.9e-11	-0.71	0.14	0.21	FALSE
53	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-5.3	6.5	1.1e-10	0.61	0.16	0.72	FALSE
30	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-4.6	6.4	1.6e-10	0.69	0.20	0.20	FALSE
54	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	7.1	6.3	2.2e-10	0.67	0.97	0.03	FALSE
22	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	7.7	6.3	2.8e-10	0.69	0.97	0.03	FALSE
47	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	5.1	-6.2	6.4e-10	-0.73	0.04	0.91	FALSE
9	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-4.7	-6.2	6.7e-10	-0.39	0.57	0.04	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-4.4	-6.2	6.9e-10	-0.68	0.06	0.71	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-5.3	-6.1	8.0e-10	-0.76	0.84	0.16	FALSE
13	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-5.0	6.1	1.1e-09	0.73	0.34	0.36	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-6.7	-6.1	1.1e-09	-0.52	0.10	0.65	FALSE
57	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	-2.2	-5.9	2.8e-09	-0.49	0.18	0.28	FALSE
36	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-5.4	5.8	5.7e-09	0.70	0.76	0.24	FALSE
34	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	5.1	5.7	9.7e-09	0.69	0.87	0.11	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A5	0.06	0.04	blup	93	0.04	8.9e-06	-1.8	5.7	1.0e-08	0.42	0.48	0.28	FALSE
16	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	8.0	-5.7	1.1e-08	-0.72	0.02	0.97	FALSE
20	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-5.4	5.7	1.5e-08	0.67	0.92	0.04	FALSE
29	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-5.2	5.5	4.1e-08	0.68	1.00	0.00	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	-4.9	5.4	5.5e-08	0.55	0.10	0.19	FALSE
25	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-5.3	5.4	5.7e-08	0.72	0.86	0.14	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RAPGEF6	0.16	0.09	enet	25	0.11	4.4e-13	-3.6	-5.3	9.3e-08	-0.44	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-5.3	5.3	1.0e-07	0.66	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-5.3	5.3	1.1e-07	0.66	1.00	0.00	FALSE
28	GTEx	Lung	AC004041.2	0.13	0.08	lasso	9	0.08	8.8e-07	-5.3	-5.3	1.1e-07	-0.47	0.96	0.01	FALSE
31	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-5.3	5.3	1.2e-07	0.68	0.95	0.05	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-4.1	-5.3	1.2e-07	-0.69	0.55	0.44	FALSE
12	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-5.2	5.3	1.4e-07	0.67	1.00	0.00	FALSE
35	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-3.7	5.2	1.5e-07	0.55	0.33	0.26	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-5.3	-5.2	1.5e-07	-0.66	0.45	0.06	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-5.3	5.2	1.7e-07	0.66	0.87	0.07	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-4.6	-5.2	1.9e-07	-0.56	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-5.2	5.2	2.2e-07	0.66	0.52	0.14	FALSE
45	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-5.2	5.2	2.3e-07	0.66	0.89	0.01	FALSE
5	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-5.3	5.2	2.7e-07	0.66	0.65	0.15	FALSE