[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr3:126,603,779-129,808,869

Best TWAS P=3.28e-90 · Best GWAS P=0 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RUVBL1	0.04	0.00	bslmm	434	0.03	3.6e-04	-0.41	-6.5	8.3e-11	0.05	0.10	0.03	TRUE
2	GTEx	Adipose Subcutaneous	EFCC1	0.12	0.03	lasso	3	0.03	2.6e-03	-6.28	6.3	3.5e-10	-0.06	0.34	0.04	TRUE
3	GTEx	Adipose Subcutaneous	RPN1	0.14	0.04	enet	19	0.06	1.9e-05	-9.03	-10.2	1.7e-24	0.37	0.91	0.02	FALSE
4	GTEx	Adipose Subcutaneous	RP11-723O4.2	0.08	0.08	enet	6	0.08	3.6e-07	5.62	6.6	5.4e-11	-0.08	0.99	0.00	FALSE
5	GTEx	Adipose Subcutaneous	RP11-723O4.9	0.06	0.06	lasso	2	0.05	7.4e-05	5.86	5.9	4.7e-09	-0.07	0.82	0.01	FALSE
6	GTEx	Adipose Visceral Omentum	ACAD9	0.16	0.01	lasso	7	0.01	1.6e-01	6.55	-7.8	5.3e-15	0.07	0.21	0.04	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-723O4.2	0.12	0.11	lasso	4	0.11	3.0e-06	5.62	5.7	1.3e-08	-0.05	0.57	0.02	FALSE
8	GTEx	Adrenal Gland	ACAD9	0.29	0.05	lasso	9	0.06	2.8e-03	-0.30	-7.9	3.1e-15	0.18	0.65	0.09	FALSE
9	GTEx	Adrenal Gland	RP11-723O4.2	0.27	0.23	lasso	8	0.21	6.0e-08	5.62	5.6	2.4e-08	-0.06	0.99	0.00	FALSE
10	GTEx	Artery Aorta	RAB7A	0.13	0.00	enet	21	0.08	5.6e-05	-15.47	16.2	3.1e-59	-0.34	0.08	0.12	TRUE
11	GTEx	Artery Aorta	RPN1	0.17	0.06	enet	27	0.07	9.7e-05	-9.69	7.0	3.3e-12	0.04	0.69	0.01	TRUE
12	GTEx	Artery Coronary	RPN1	0.15	0.05	lasso	5	0.03	3.0e-02	-9.86	-9.4	4.4e-21	0.32	0.13	0.04	FALSE
13	GTEx	Artery Tibial	RPN1	0.12	0.07	lasso	4	0.05	1.3e-04	-9.85	-8.1	8.1e-16	0.29	0.96	0.00	FALSE
14	GTEx	Artery Tibial	RP11-723O4.2	0.15	0.10	lasso	2	0.09	1.4e-07	5.63	5.6	1.8e-08	-0.06	0.98	0.00	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RPL32P3	0.42	0.01	enet	11	-0.01	4.8e-01	-0.66	7.1	1.3e-12	-0.10	0.04	0.35	TRUE
16	GTEx	Brain Cerebellum	RP11-723O4.2	0.18	0.02	lasso	4	0.04	3.0e-02	5.62	6.0	2.0e-09	-0.07	0.12	0.06	FALSE
17	GTEx	Brain Cerebellum	RP11-723O4.9	0.27	0.24	lasso	3	0.22	2.9e-07	5.62	5.7	1.5e-08	-0.05	0.68	0.02	FALSE
18	GTEx	Brain Cortex	RPN1	0.30	0.14	lasso	5	0.15	7.0e-05	17.52	15.0	5.9e-51	-0.16	0.18	0.05	FALSE
19	GTEx	Brain Hippocampus	RP11-723O4.9	0.24	0.11	enet	15	0.08	5.1e-03	5.62	5.7	1.1e-08	-0.06	0.24	0.04	FALSE
20	GTEx	Breast Mammary Tissue (Female)	RP11-723O4.2	0.27	0.25	lasso	3	0.26	1.9e-08	5.62	5.8	8.6e-09	-0.05	0.92	0.00	FALSE
21	GTEx	Breast Mammary Tissue (Female)	RP11-723O4.9	0.32	0.24	lasso	5	0.22	4.4e-07	5.86	5.7	1.2e-08	-0.06	0.68	0.02	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	RP11-723O4.9	0.24	0.25	lasso	1	0.20	5.0e-07	5.28	5.3	1.3e-07	-0.04	0.78	0.02	TRUE
23	GTEx	Cells Transformed fibroblasts	ACAD9	0.32	0.03	enet	26	0.10	2.8e-08	-0.15	-10.4	1.8e-25	0.18	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	RP11-723O4.2	0.16	0.16	lasso	7	0.16	9.3e-12	5.62	5.4	7.5e-08	-0.07	1.00	0.00	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-723O4.9	0.13	0.12	lasso	6	0.12	4.1e-09	5.62	5.8	8.9e-09	-0.06	1.00	0.00	FALSE
26	GTEx	Colon Sigmoid	RP11-723O4.2	0.24	0.11	lasso	8	0.09	5.2e-04	5.62	6.0	1.8e-09	-0.07	0.84	0.01	TRUE
27	GTEx	Colon Sigmoid	RP11-723O4.9	0.20	0.10	lasso	4	0.08	7.9e-04	5.62	6.9	7.2e-12	-0.01	0.32	0.03	FALSE
28	GTEx	Colon Transverse	ACAD9	0.47	0.20	enet	24	0.29	5.2e-14	0.17	-5.2	2.4e-07	0.09	1.00	0.00	FALSE
29	GTEx	Colon Transverse	RP11-723O4.9	0.40	0.18	lasso	14	0.15	8.6e-08	5.61	7.9	2.8e-15	-0.08	0.99	0.00	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	RPN1	0.13	0.10	lasso	3	0.08	9.9e-04	-9.84	-10.1	3.4e-24	0.34	0.39	0.04	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	RP11-723O4.2	0.12	0.10	enet	9	0.07	1.5e-03	5.86	6.0	2.6e-09	-0.07	0.64	0.03	FALSE
32	GTEx	Esophagus Mucosa	ACAD9	0.17	0.02	lasso	6	0.03	2.2e-03	-0.15	-11.1	1.9e-28	0.20	0.52	0.02	FALSE
33	GTEx	Esophagus Mucosa	RP11-723O4.2	0.37	0.35	lasso	7	0.36	1.0e-24	5.62	6.9	4.8e-12	-0.10	1.00	0.00	FALSE
34	GTEx	Esophagus Mucosa	RP11-723O4.9	0.15	0.16	lasso	7	0.14	8.6e-10	5.62	7.1	1.5e-12	-0.10	1.00	0.00	FALSE
35	GTEx	Esophagus Muscularis	RPN1	0.19	0.11	lasso	6	0.10	7.3e-07	-9.84	-11.0	4.0e-28	0.36	0.92	0.02	TRUE
36	GTEx	Esophagus Muscularis	RP11-723O4.2	0.13	0.07	lasso	4	0.09	3.0e-06	5.61	6.0	2.0e-09	-0.07	0.95	0.00	FALSE
37	GTEx	Liver	RP11-723O4.2	0.29	0.22	lasso	4	0.18	1.3e-05	5.63	5.8	8.2e-09	-0.06	0.60	0.02	FALSE
38	GTEx	Liver	RP11-723O4.9	0.42	0.25	lasso	14	0.13	1.8e-04	5.62	6.1	8.3e-10	-0.06	0.74	0.02	FALSE
39	GTEx	Lung	EEFSEC	0.11	0.02	enet	41	0.06	2.3e-05	0.87	6.3	3.0e-10	-0.27	0.40	0.02	FALSE
40	GTEx	Lung	RPN1	0.08	0.06	lasso	4	0.04	2.6e-04	-9.03	-9.6	8.1e-22	0.32	0.56	0.02	FALSE
41	GTEx	Lung	RP11-723O4.2	0.21	0.17	lasso	4	0.17	8.7e-13	5.62	5.8	5.4e-09	-0.06	1.00	0.00	FALSE
42	GTEx	Muscle Skeletal	EEFSEC	0.05	0.01	lasso	5	0.02	4.3e-03	-7.15	6.0	2.3e-09	-0.14	0.71	0.01	FALSE
43	GTEx	Nerve Tibial	RAB7A	0.18	0.09	enet	31	0.13	1.2e-09	3.34	7.1	1.8e-12	-0.25	0.51	0.07	FALSE
44	GTEx	Pancreas	RP11-723O4.2	0.17	0.20	lasso	1	0.19	1.4e-08	5.63	5.6	1.8e-08	-0.06	0.95	0.00	FALSE
45	GTEx	Pancreas	RP11-723O4.9	0.18	0.23	lasso	1	0.22	1.2e-09	5.63	5.6	1.8e-08	-0.06	0.99	0.00	FALSE
46	GTEx	Pituitary	RP11-723O4.2	0.48	0.35	lasso	4	0.32	6.9e-09	5.62	6.0	1.5e-09	-0.06	0.97	0.00	FALSE
47	GTEx	Pituitary	RP11-723O4.9	0.45	0.45	lasso	6	0.41	2.3e-11	5.63	5.2	1.7e-07	-0.05	0.99	0.00	FALSE
48	GTEx	Prostate	RP11-723O4.2	0.43	0.28	enet	19	0.31	1.2e-08	5.61	5.3	1.1e-07	-0.10	0.92	0.00	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	ACAD9	0.43	-0.01	enet	22	0.01	7.7e-02	0.13	-10.9	7.4e-28	0.13	0.13	0.04	TRUE
50	GTEx	Skin Not Sun Exposed Suprapubic	RP11-723O4.2	0.22	0.25	lasso	5	0.25	6.6e-14	5.86	6.0	1.7e-09	-0.07	1.00	0.00	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RP11-723O4.9	0.13	0.16	enet	10	0.17	1.3e-09	5.62	6.0	2.4e-09	-0.07	1.00	0.00	FALSE
52	GTEx	Skin Sun Exposed Lower leg	RP11-723O4.2	0.21	0.26	lasso	3	0.26	2.8e-21	5.62	5.8	5.4e-09	-0.07	1.00	0.00	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RPL32P3	0.18	0.01	enet	13	0.04	3.0e-04	-3.77	5.8	8.1e-09	-0.03	0.33	0.07	TRUE
54	GTEx	Skin Sun Exposed Lower leg	RP11-723O4.9	0.19	0.20	lasso	2	0.20	4.5e-16	5.63	5.8	6.6e-09	-0.06	1.00	0.00	FALSE
55	GTEx	Spleen	RP11-723O4.2	0.27	0.18	lasso	5	0.18	2.8e-05	5.61	7.6	3.0e-14	-0.09	0.24	0.05	TRUE
56	GTEx	Spleen	RP11-723O4.9	0.34	0.23	lasso	4	0.21	4.1e-06	5.61	5.6	2.0e-08	-0.06	0.39	0.04	FALSE
57	GTEx	Stomach	RP11-723O4.2	0.23	0.19	lasso	6	0.24	1.0e-11	5.63	6.0	2.1e-09	-0.07	1.00	0.00	FALSE
58	GTEx	Stomach	RP11-723O4.9	0.32	0.22	lasso	11	0.20	1.1e-09	5.61	7.0	2.8e-12	-0.09	1.00	0.00	FALSE
59	GTEx	Testis	RP11-723O4.2	0.44	0.33	lasso	5	0.31	3.3e-14	5.61	8.0	1.1e-15	-0.13	1.00	0.00	FALSE
60	GTEx	Thyroid	RPN1	0.16	0.04	lasso	3	0.08	1.0e-06	-9.69	-8.4	4.8e-17	0.31	0.99	0.00	TRUE
61	GTEx	Thyroid	ACAD9	0.65	0.18	enet	15	0.35	1.0e-27	-0.15	-6.9	4.2e-12	0.12	1.00	0.00	FALSE
62	GTEx	Thyroid	RP11-723O4.2	0.30	0.27	lasso	3	0.27	1.3e-20	5.61	5.4	6.4e-08	-0.06	1.00	0.00	FALSE
63	GTEx	Vagina	RP11-723O4.2	0.39	0.27	lasso	10	0.18	5.0e-05	5.63	5.7	1.2e-08	-0.06	0.32	0.06	FALSE
64	GTEx	Vagina	RP11-723O4.9	0.30	0.12	lasso	9	0.20	3.0e-05	5.63	5.4	5.6e-08	0.01	0.17	0.07	FALSE
65	GTEx	Whole Blood	RP11-723O4.2	0.07	0.07	lasso	2	0.06	1.8e-06	5.62	5.6	1.8e-08	-0.06	0.99	0.00	FALSE
66	GTEx	Whole Blood	RP11-723O4.9	0.07	0.06	lasso	1	0.06	4.8e-06	5.63	5.6	1.8e-08	-0.06	0.98	0.00	FALSE
67	METSIM	Adipose	RP11-723O4.9	0.10	0.07	bslmm	353	0.08	6.5e-12	5.62	7.3	3.8e-13	-0.04	1.00	0.00	FALSE
68	METSIM	Adipose	RPN1	0.07	0.05	blup	362	0.05	2.3e-08	-4.18	10.2	3.3e-24	-0.01	1.00	0.00	FALSE
69	METSIM	Adipose	RUVBL1	0.04	0.00	enet	18	0.01	2.6e-03	1.92	-10.6	2.8e-26	0.04	0.12	0.04	FALSE
70	METSIM	Adipose	TPRA1	0.10	0.03	lasso	19	0.06	5.6e-10	5.00	-5.2	2.0e-07	0.01	0.93	0.06	TRUE
71	NTR	Blood	ACAD9	0.02	0.01	bslmm	322	0.01	2.5e-04	-23.14	-10.0	1.6e-23	0.23	0.55	0.14	FALSE
72	NTR	Blood	RPN1	0.03	0.00	bslmm	335	0.01	8.5e-04	-11.65	-11.2	2.8e-29	0.24	0.04	0.06	FALSE
73	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC90246	0.11	0.08	blup	48	0.09	6.5e-08	11.60	-20.1	3.3e-90	0.24	0.74	0.23	TRUE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACAD9	0.03	0.00	blup	51	0.01	4.5e-03	0.13	-13.6	3.7e-42	0.25	0.01	0.78	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB43	0.02	0.02	blup	35	0.02	7.8e-05	-6.66	-7.5	4.4e-14	0.01	0.03	0.95	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CNBP	0.02	0.02	blup	24	0.01	9.7e-03	-6.53	-7.3	2.7e-13	0.01	0.01	0.60	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TPRA1	0.02	0.01	blup	29	0.01	1.7e-02	4.99	-5.4	7.6e-08	-0.05	0.00	0.80	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC90246	0.09	0.09	lasso	4	0.10	4.1e-11	9.97	-10.0	1.1e-23	0.14	1.00	0.00	TRUE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB43	0.02	0.02	blup	36	0.01	9.2e-03	-6.73	-6.6	3.6e-11	0.00	0.02	0.90	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1257	0.11	0.00	blup	60	0.03	2.9e-04	5.61	11.1	1.5e-28	-0.18	0.03	0.57	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPN1	0.06	0.04	lasso	4	0.04	1.7e-05	-4.15	5.9	4.5e-09	0.20	0.76	0.02	FALSE
82	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPN1	0.10	0.02	blup	59	0.02	3.6e-02	-11.65	-10.5	7.3e-26	0.28	0.09	0.06	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB43	0.05	0.00	lasso	4	0.06	1.5e-03	-6.20	-6.3	3.1e-10	-0.01	0.03	0.33	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACAD9	0.07	0.04	blup	46	0.03	8.6e-04	6.62	-9.0	2.0e-19	0.10	0.34	0.10	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC90246	0.06	0.06	enet	8	0.05	1.1e-05	9.97	-17.7	1.0e-69	0.27	0.88	0.09	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB43	0.05	0.08	enet	8	0.07	8.2e-08	-6.71	-7.2	6.4e-13	0.01	0.02	0.98	TRUE
87	The Cancer Genome Atlas	Thyroid Carcinoma	ACAD9	0.19	0.02	blup	51	0.09	4.2e-09	0.13	-5.9	4.6e-09	0.03	0.27	0.10	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	LOC90246	0.08	0.04	lasso	3	0.04	5.8e-05	11.60	-10.7	1.3e-26	0.17	0.31	0.07	FALSE