[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr10:80,723,467-82,984,432

Best TWAS P=5.56e-24 · Best GWAS P=2.39e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Brain Frontal Cortex BA9	FAM213A	0.29	0.13	lasso	4	0.10	1.0e-03	-9.1	-10.1	5.6e-24	0.77	0.03	0.86	TRUE
6	CommonMind	Brain Pre-frontal Cortex	TSPAN14	0.15	0.13	enet	17	0.15	3.2e-18	-7.8	9.7	2.6e-22	-0.68	1.00	0.00	TRUE
61	ROSMAP	Brain Pre-frontal Cortex	PLAC9	0.21	0.17	lasso	14	0.21	5.5e-27	5.6	7.9	2.1e-15	-0.46	1.00	0.00	TRUE
24	GTEx	Cells Transformed fibroblasts	FAM213A	0.59	0.00	enet	3	0.00	4.6e-01	8.5	7.8	4.0e-15	-0.59	0.15	0.14	TRUE
8	GTEx	Adipose Subcutaneous	RP11-119F19.2	0.25	0.10	enet	38	0.22	1.8e-17	-3.9	7.2	5.7e-13	-0.12	0.98	0.02	TRUE
63	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MBL1P	0.07	0.02	blup	61	0.04	1.1e-04	-3.2	6.9	3.8e-12	-0.04	0.04	0.13	TRUE
32	GTEx	Lung	SFTPD	0.09	0.04	enet	27	0.03	2.1e-03	-6.6	6.5	1.1e-10	-0.22	0.42	0.06	TRUE
7	GTEx	Adipose Subcutaneous	BEND3P3	0.10	0.04	enet	14	0.06	5.2e-06	-3.0	5.9	3.8e-09	0.00	0.31	0.23	TRUE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf58	0.02	0.03	enet	2	0.02	1.1e-05	9.3	-9.7	3.9e-22	0.75	0.28	0.70	FALSE
49	GTEx	Testis	FAM213A	0.14	0.08	lasso	4	0.02	2.7e-02	9.3	-9.5	1.7e-21	0.75	0.09	0.78	FALSE
51	GTEx	Thyroid	FAM213A	0.11	0.05	lasso	8	0.06	1.4e-05	-8.5	-9.3	1.3e-20	0.74	0.34	0.59	FALSE
40	GTEx	Pituitary	SFTPD	0.32	0.25	lasso	7	0.32	8.4e-09	-8.9	-9.2	3.5e-20	0.13	0.56	0.03	FALSE
31	GTEx	Lung	TSPAN14	0.07	0.02	lasso	5	0.03	1.2e-03	-6.4	-9.0	1.6e-19	0.65	0.25	0.62	FALSE
20	GTEx	Brain Frontal Cortex BA9	RP11-137H2.6	0.20	0.11	lasso	5	0.08	4.8e-03	-9.5	-8.9	3.7e-19	0.83	0.05	0.89	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DYDC2	0.11	0.02	enet	4	0.06	1.3e-03	-5.5	8.8	1.6e-18	-0.56	0.01	0.84	FALSE
53	GTEx	Whole Blood	TSPAN14	0.08	0.08	enet	12	0.07	7.6e-07	8.2	-8.8	2.0e-18	0.79	0.03	0.97	FALSE
56	METSIM	Adipose	RP11-137H2.6	0.11	0.11	lasso	9	0.11	1.1e-16	9.1	8.7	2.5e-18	-0.63	0.33	0.67	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C10orf58	0.03	0.01	blup	65	0.01	2.9e-02	-5.5	-8.6	6.4e-18	0.72	0.05	0.27	FALSE
16	GTEx	Brain Cerebellum	PLAC9	0.13	0.02	enet	14	0.01	1.4e-01	-6.9	8.6	1.2e-17	-0.63	0.14	0.19	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C10orf58	0.04	0.01	blup	65	0.02	6.9e-03	-4.3	-8.3	9.4e-17	0.60	0.08	0.22	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf58	0.07	0.00	blup	65	0.03	3.8e-04	-9.3	-8.2	1.6e-16	0.61	0.09	0.36	FALSE
15	GTEx	Brain Cerebellum	TSPAN14	0.40	0.08	enet	37	0.16	2.3e-05	9.3	-8.2	1.7e-16	0.61	0.12	0.72	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	FAM213A	0.03	0.01	blup	556	0.02	2.2e-03	-5.3	-8.2	2.3e-16	0.63	0.45	0.32	FALSE
62	YFS	Blood	TSPAN14	0.31	0.34	lasso	7	0.38	8.3e-132	-8.1	-8.1	4.0e-16	0.51	1.00	0.00	FALSE
57	METSIM	Adipose	TSPAN14	0.06	0.01	blup	570	0.02	2.5e-04	-9.6	-7.8	4.0e-15	0.58	0.03	0.97	FALSE
58	NTR	Blood	C10orf58	0.02	0.01	blup	565	0.01	2.7e-03	-9.5	7.8	4.1e-15	-0.69	0.04	0.94	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFTPD	0.07	0.04	blup	58	0.03	1.7e-04	-8.9	-7.7	1.4e-14	0.12	0.00	1.00	FALSE
50	GTEx	Thyroid	TSPAN14	0.11	0.05	lasso	5	0.07	8.4e-06	-7.4	-7.6	2.5e-14	0.56	0.59	0.40	FALSE
44	GTEx	Skin Sun Exposed Lower leg	TSPAN14	0.13	0.04	lasso	4	0.06	1.9e-05	-8.1	-7.5	8.4e-14	0.42	0.60	0.07	FALSE
39	GTEx	Pancreas	SFTPD	0.18	0.15	lasso	8	0.10	4.5e-05	-7.7	-7.3	2.4e-13	0.08	0.42	0.03	FALSE
30	GTEx	Esophagus Mucosa	RP11-137H2.6	0.22	0.17	enet	27	0.19	1.1e-12	-5.2	-7.3	3.5e-13	0.59	1.00	0.00	FALSE
29	GTEx	Esophagus Mucosa	MBL1P	0.10	0.00	enet	16	0.02	1.5e-02	5.2	-7.2	4.4e-13	0.45	0.10	0.65	FALSE
19	GTEx	Brain Frontal Cortex BA9	SFTPD	0.35	0.13	lasso	9	0.19	1.2e-05	5.2	-7.2	6.6e-13	0.15	0.50	0.04	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	TSPAN14	0.17	0.02	blup	84	0.04	1.9e-03	9.3	7.2	6.7e-13	-0.62	0.03	0.48	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	SFTPD	0.30	0.30	enet	10	0.28	4.6e-08	5.4	-7.2	8.6e-13	0.12	0.68	0.02	FALSE
27	GTEx	Esophagus Mucosa	FAM213A	0.23	0.25	lasso	3	0.25	1.4e-16	-5.7	-7.0	2.9e-12	0.66	0.94	0.06	FALSE
11	GTEx	Artery Tibial	RP11-119F19.2	0.20	0.06	enet	26	0.18	7.2e-14	-2.2	7.0	3.3e-12	-0.10	0.95	0.04	FALSE
46	GTEx	Skin Sun Exposed Lower leg	RP11-119F19.2	0.25	0.15	enet	30	0.18	5.5e-15	-3.0	6.9	6.4e-12	-0.12	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	SFTPD	0.07	0.02	enet	10	0.04	1.3e-04	-6.6	-6.8	7.7e-12	0.12	0.06	0.52	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	DYDC1	0.02	0.01	blup	41	0.01	9.4e-03	-5.7	6.7	2.7e-11	-0.59	0.04	0.56	FALSE
13	GTEx	Brain Caudate basal ganglia	SFTPD	0.29	0.32	lasso	5	0.31	1.2e-09	5.8	-6.6	3.4e-11	0.14	0.93	0.00	FALSE
35	GTEx	Muscle Skeletal	RP11-119F19.2	0.12	0.03	lasso	7	0.06	2.3e-06	4.1	6.6	4.1e-11	-0.17	0.89	0.05	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	TSPAN14	0.12	0.12	enet	9	0.12	7.4e-12	-4.5	-6.5	7.8e-11	0.59	0.98	0.02	FALSE
9	GTEx	Adipose Subcutaneous	MBL1P	0.24	0.18	lasso	9	0.19	2.6e-15	-5.9	-6.5	8.9e-11	0.18	1.00	0.00	FALSE
37	GTEx	Nerve Tibial	RP11-119F19.2	0.18	0.11	enet	25	0.12	7.0e-09	-3.9	6.4	1.8e-10	-0.09	0.92	0.01	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLAC9	0.12	0.07	blup	61	0.11	1.6e-12	-5.2	6.4	1.8e-10	-0.30	0.26	0.74	FALSE
41	GTEx	Pituitary	MBL1P	0.49	0.05	enet	36	0.12	8.4e-04	-4.3	-6.2	5.3e-10	0.26	0.19	0.20	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PLAC9	0.17	0.10	lasso	6	0.15	1.0e-17	-5.6	6.2	5.4e-10	-0.29	1.00	0.00	FALSE
42	GTEx	Prostate	MBL1P	0.24	0.02	lasso	5	0.01	2.1e-01	-1.4	-6.2	6.3e-10	0.47	0.05	0.10	FALSE
45	GTEx	Skin Sun Exposed Lower leg	BEND3P3	0.19	0.02	enet	33	0.07	1.7e-06	-3.0	6.2	7.5e-10	-0.02	0.66	0.08	FALSE
33	GTEx	Lung	RP11-119F19.2	0.24	0.09	lasso	12	0.18	1.5e-13	-4.6	6.0	1.7e-09	-0.14	0.99	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANXA11	0.15	0.11	lasso	10	0.16	3.6e-19	-4.8	6.0	1.8e-09	-0.47	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SFTPD	0.27	0.26	enet	17	0.31	7.0e-38	5.8	-6.0	2.2e-09	0.09	1.00	0.00	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	RP11-119F19.2	0.24	0.13	enet	11	0.20	5.1e-11	-3.0	5.9	3.7e-09	-0.09	0.99	0.00	FALSE
47	GTEx	Spleen	RP11-119F19.2	0.33	0.02	lasso	7	0.06	1.5e-02	4.1	5.8	7.5e-09	-0.12	0.03	0.67	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	RP11-119F19.2	0.21	0.12	enet	22	0.09	3.7e-04	-2.8	5.8	8.7e-09	-0.07	0.30	0.27	FALSE
52	GTEx	Thyroid	RP11-137H2.6	0.10	0.03	enet	26	0.05	1.8e-04	-5.2	-5.7	1.0e-08	0.60	0.67	0.25	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	RP11-119F19.2	0.32	0.11	enet	50	0.14	2.8e-05	-3.2	5.7	1.3e-08	-0.05	0.15	0.16	FALSE
12	GTEx	Artery Tibial	MBL1P	0.43	0.22	lasso	16	0.36	5.5e-29	-5.6	-5.7	1.5e-08	0.16	1.00	0.00	FALSE
36	GTEx	Muscle Skeletal	MBL1P	0.07	0.00	enet	20	0.01	2.0e-02	-1.4	-5.6	1.7e-08	0.31	0.31	0.19	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MBL1P	0.04	0.01	blup	61	0.04	6.7e-05	-6.6	-5.6	1.8e-08	0.13	0.16	0.10	FALSE
54	METSIM	Adipose	FAM213A	0.04	0.01	enet	22	0.01	2.9e-02	-4.2	5.6	2.0e-08	-0.47	0.12	0.59	FALSE
17	GTEx	Brain Cortex	PLAC9	0.29	0.03	enet	28	0.12	4.6e-04	5.6	5.6	2.3e-08	-0.40	0.14	0.12	FALSE
48	GTEx	Stomach	RP11-119F19.2	0.20	0.14	enet	32	0.10	2.1e-05	-3.9	5.6	2.3e-08	0.02	0.54	0.05	FALSE
38	GTEx	Ovary	MBL1P	0.31	0.16	lasso	3	0.22	4.4e-06	-5.6	-5.6	2.4e-08	0.15	0.26	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DYDC2	0.13	0.13	lasso	2	0.12	7.9e-15	-5.5	5.5	3.2e-08	-0.24	1.00	0.00	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	ANXA11	0.18	0.19	lasso	4	0.20	1.9e-24	-4.5	5.5	4.1e-08	-0.47	1.00	0.00	FALSE
55	METSIM	Adipose	NUTM2B	0.12	0.16	lasso	4	0.15	3.6e-22	-5.5	5.5	4.5e-08	-0.08	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C10orf57	0.06	0.00	blup	43	0.01	9.9e-03	-4.3	-5.5	4.9e-08	0.22	0.01	0.09	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MBL1P	0.09	0.08	lasso	4	0.08	2.9e-10	-5.6	-5.3	1.1e-07	0.14	1.00	0.00	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	BEND3P3	0.31	0.04	enet	15	0.03	3.6e-02	-3.0	5.3	1.4e-07	-0.07	0.20	0.05	FALSE
22	GTEx	Breast Mammary Tissue (Male)	MBL1P	0.21	0.08	enet	8	0.11	1.7e-03	-5.7	-5.2	1.5e-07	0.14	0.14	0.06	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	DYDC1	0.02	0.02	blup	41	0.02	2.8e-05	-5.3	5.2	1.6e-07	-0.50	0.93	0.04	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-773D16.1	0.34	0.09	enet	23	0.16	8.0e-05	-5.3	-5.2	1.9e-07	0.31	0.10	0.07	FALSE
10	GTEx	Artery Tibial	BEND3P3	0.22	0.07	enet	14	0.10	5.8e-08	-2.0	5.2	2.1e-07	-0.05	0.97	0.00	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MBL1P	0.11	0.09	lasso	7	0.09	1.1e-05	5.3	-5.2	2.1e-07	0.13	0.67	0.15	FALSE
34	GTEx	Lung	RP11-506M13.3	0.08	0.01	lasso	3	0.02	1.3e-02	5.4	5.1	2.9e-07	-0.11	0.25	0.34	FALSE
28	GTEx	Esophagus Mucosa	TMEM254	0.14	0.05	lasso	3	0.06	5.0e-05	-2.2	-5.1	3.1e-07	-0.02	0.30	0.03	FALSE