Hub : Genes

KLHL21

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0414 0.019 0.0041 0.027 0.021 0.018 0.021 0.021 1.8e-04 0.00095 0.0017 8e-04 0.00078
2 TCGA Testicular Germ Cell Tumors 0.1080 0.052 0.0010 0.117 0.041 0.065 NA 0.087 6.4e-05 0.01400 0.0025 NA 0.00054

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 2.7 1.6 -0.4
Bipolar Disorder or Schizophrenia 3.6 8.8 14.3 3.8 -1.8
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.6 -0.3
Depression (Nagel 2018) 3.0 4.5 5.2 2.3 -1.9
Intelligence (Savage-Jansen 2018) 2.0 6.1 9.2 -3.0 1.7
Neuroticism (Nagel 2018) 0.3 0.8 1.3 1.1 -0.5
Schizophrenia (2018) 4.1 8.4 12.5 3.5 -2.1
Schizophrenia vs Biploar Disorder 2.7 3.5 5.2 2.3 -1.4
Worry (Nagel 2018) 0.2 0.5 0.5 0.7 -0.7
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 0.0 -0.7
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.0
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.1 -0.3
Crohns Disease (2017) 0.1 0.3 0.5 -0.1 -0.7
Irritable Bowel Disease (IBD) 0.4 1.1 1.7 0.6 -1.3
Ulcerative Colitis (UC) 0.6 1.2 1.6 0.9 -1.2
Major Depression (MDD) 6.2 7.6 8.1 2.7 -2.8
Reaction Time 0.1 0.2 0.3 0.5 -0.2
Verbal and Numeric Reasoning (VNR) 2.5 6.1 6.3 -2.5 2.4
Breast Cancer 0.0 0.0 0.0 0.1 0.0
Ovarian Cancer 0.1 0.1 0.3 0.5 -0.1
Prostate Cancer 1.1 1.5 1.7 1.3 -1.2
Age at First Birth 1.1 1.6 3.2 -0.0 -1.8
Bipolar Disorder (2011) 0.1 0.1 0.2 0.0 -0.4
Body Mass Index (BMI) (2010) 3.9 5.4 9.9 -0.9 3.1
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.6 -0.0
Crohns Disease (2012) 0.4 0.7 1.2 1.1 -0.4
Mean Putamen Volume 1.2 1.4 1.4 1.2 -1.2
Fasting Glucose 0.8 1.0 1.7 -1.3 0.5
HbA1C 4.0 4.4 7.1 -1.3 2.7
HDL Cholesterol 0.7 1.1 1.9 0.5 -1.4
LDL Cholesterol 0.1 0.2 0.4 -0.0 0.7
Lupus 3.7 5.7 11.0 -3.3 0.6
Neuroticism (2016) 1.0 1.4 2.6 -0.5 1.6
Primary Biliary Cirrhosis 0.4 0.5 1.0 -1.0 0.3
Rheumatoid Arthritis 0.2 0.3 0.3 -0.5 0.6
Schizophrenia (2014) 3.1 6.9 10.4 3.2 -1.9
Triglycerides 1.6 2.5 3.9 -1.1 2.0
Type 2 Diabetes (T2D) (2012) 4.9 5.7 6.5 -2.2 2.5
Ulcerative Colitis 2.1 3.0 4.5 2.1 -1.2
Blood Eosinophil Count 0.1 0.5 0.5 -0.7 0.6
Blood Platelet Count 0.3 3.3 5.9 -0.9 2.4
Blood Red Count 0.9 9.0 11.2 3.4 -2.6
Blood White Count 0.1 0.5 0.8 0.4 0.9
Heel T-Score 7.9 63.0 65.3 -7.8 8.1
BMI 3.3 19.0 25.6 -3.5 5.1
Height 0.5 9.1 13.4 2.2 -3.7
Waist Hip Ratio (WHR) 0.6 2.5 3.3 -1.8 1.3
Systolic Blood Pressure 4.7 23.3 23.7 -4.8 4.9
Smoking Status 1.2 3.0 3.5 1.9 -1.6
Allergy or Eczema 0.4 1.1 1.7 1.3 -0.7
Cardiovascular Disease 5.5 18.3 18.9 -4.2 4.3
Hypothyroidism (self reported) 0.2 0.6 0.9 1.0 0.5
Respiratory disease 0.0 0.0 0.1 -0.0 -0.3
Type 2 Diabetes (T2D) (2018) 3.8 7.1 8.5 -2.4 2.9
Lung FEV1/FVC ratio 8.1 40.9 43.2 -6.2 6.6
Lung FVC 0.1 0.6 1.2 -0.3 -1.1
Neuroticism 0.4 1.0 1.6 1.3 -0.6
Chronotype (morning person) 2.3 5.3 7.0 -2.6 1.9
Hair Pigment 0.1 3.5 4.0 1.7 -2.0
Tanning 0.1 0.9 1.7 1.3 -0.2
Hand grip strength (left) 0.8 2.2 3.2 1.1 -1.8
Number of treatments/medications taken 0.6 1.1 1.7 -1.3 0.8
Average weekly spirits intake 1.9 2.4 4.3 2.1 -0.7
Sensitivity / hurt feelings 0.2 0.4 0.7 0.4 -0.8
Frequency of depressed mood in last 2 weeks 0.8 1.1 1.1 1.1 -1.0
Hearing difficulty/problems: Yes 0.9 1.4 2.9 1.7 0.1
Relative age of first facial hair 0.4 0.7 1.0 0.7 -1.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 0.2 -0.4
Ever used hormone-replacement therapy (HRT) 2.6 3.3 4.4 1.5 -2.1
Ever had hysterectomy (womb removed) 1.0 1.2 2.2 1.5 -0.4
Systolic blood pressure, automated reading 2.2 6.4 6.8 -2.6 2.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.0 0.5 -1.0
Angina 1.7 2.3 3.6 -1.0 1.9
Medication for hormone replacement therapy 2.2 2.4 3.1 1.3 -1.8
Vitamin and mineral supplements 2.5 3.4 4.6 -1.5 2.1
Supplements: Zinc 0.6 0.6 0.7 0.8 -0.8
Medication: Co-codamol 0.1 0.2 0.2 0.5 -0.3
Medication: Metformin 3.0 4.3 4.4 -2.0 2.1
Diabetes (father) 0.2 0.2 0.4 0.2 0.6
Diabetes (mother) 2.1 2.7 2.9 -1.7 1.6
Severe depression (siblings) 1.1 1.2 1.7 1.3 -0.9
Pack years adult smoking proportion 0.4 0.6 0.7 -0.8 0.7
Impedance of leg (right) 0.1 0.3 0.3 0.5 -0.6
Leg fat-free mass (left) 0.3 1.8 1.9 -1.4 1.3
Trunk fat percentage 2.2 9.0 11.5 -2.5 3.4
Hand grip strength (right) 0.2 0.6 1.0 0.5 -1.0
Townsend deprivation index at recruitment 0.1 0.2 0.2 -0.5 -0.4
Current tobacco smoking 0.3 0.5 0.9 1.0 0.2
Average weekly fortified wine intake 1.8 2.1 2.4 -1.6 1.3
Maternal smoking around birth 1.3 1.8 1.9 1.3 -1.4
Fed-up feelings 0.3 0.6 0.7 -0.8 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.8 1.4 -0.4
Relative age voice broke 0.6 1.0 1.9 1.4 0.2
Taking other prescription medications 0.5 0.8 0.8 -0.9 0.8
Age when periods started (menarche) 0.1 0.2 0.5 -0.1 -0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.7 0.1 0.8
Heel bone mineral density (BMD) T-score, automated (left) 4.4 10.0 13.6 -2.5 3.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.5 1.2 -0.5
Qualifications: CSEs or equivalent 0.7 0.9 1.1 -0.9 1.1
Serious illness, injury or assault to yourself 0.2 0.3 0.5 0.7 0.3
High blood pressure 7.1 19.7 20.4 -4.4 4.5
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 0.9 0.2
Multivitamins +/- minerals 2.5 3.1 3.3 1.7 -1.8
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.0 0.4
Supplements: Glucosamine 0.0 0.0 0.0 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 1.4 -1.2 1.1
Medication: Atenolol 3.9 4.9 5.1 -2.2 2.3
Medication: Levothyroxine sodium 0.8 1.4 2.5 1.6 -0.5
Sitting height 1.8 12.7 19.0 2.5 -4.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.2 -0.5
High blood pressure (mother) 8.7 12.3 16.6 -2.8 4.1
Body mass index (BMI) 3.4 14.4 19.3 -3.1 4.4
Impedance of leg (left) 0.1 0.4 0.5 0.5 -0.7
Leg predicted mass (left) 0.3 1.6 1.8 -1.4 1.1
Trunk fat mass 2.3 9.8 11.6 -2.8 3.4
Waist circumference 4.1 14.8 18.3 -3.4 4.3
Number of incorrect matches in round 1.1 1.8 3.2 0.6 -1.8
Past tobacco smoking 1.0 1.9 2.2 -1.5 1.2
Alcohol usually taken with meals 0.3 0.4 0.9 -0.9 -0.0
Nervous feelings 0.0 0.1 0.1 -0.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 5.5 2.3 -1.1
Hearing difficulty/problems with background noise 2.2 3.5 6.2 2.5 -0.9
Hair/balding pattern: Pattern 2 0.4 0.6 0.7 0.8 -0.7
Had menopause 6.3 7.8 13.2 1.6 -3.6
Had other major operations 3.1 3.8 4.3 2.1 -1.8
Forced vital capacity (FVC) 0.8 2.9 4.0 1.4 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 4.2 9.5 14.1 -2.2 3.8
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.6 1.9 -0.7
Qualifications: None of the above 1.4 3.1 3.8 -1.9 1.6
Financial difficulties in last 2 years 1.8 2.4 4.8 -0.1 2.2
Mouth/teeth dental problems 0.3 0.5 1.0 -0.1 -1.0
Heart attack 0.9 1.2 2.3 -0.3 1.5
Allergy 0.1 0.2 0.4 -0.6 0.1
Pain all over the body in last month 0.5 0.5 0.6 0.6 -0.7
Diabetes (self-reported) 4.7 7.3 9.5 -2.2 3.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 2.7 1.6 -0.8
Medication: Ramipril 5.0 6.4 6.4 -2.5 2.5
Medication: Simvastatin 10.1 14.9 18.5 -3.4 4.3
Fluid intelligence score 1.7 3.6 4.4 -1.7 2.1
Illnesses of siblings 3.1 4.4 7.8 1.0 -2.8
Neuroticism score 0.1 0.3 0.5 0.7 -0.3
Weight 1.4 7.1 8.0 -2.5 2.8
Impedance of arm (right) 0.5 2.3 2.9 1.3 -1.7
Arm fat percentage (right) 3.3 12.9 17.3 -2.9 4.2
Trunk fat-free mass 0.1 0.6 1.0 -1.0 0.3
Hip circumference 1.7 7.4 9.4 -2.3 3.1
Time employed in main current job 0.2 0.2 0.4 0.2 0.6
Alcohol intake versus 10 years previously 1.5 2.3 3.5 1.9 -1.1
Father’s age at death 1.2 1.6 1.7 1.3 -1.2
Worrier / anxious feelings 0.0 0.1 0.1 0.3 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.0 0.2 1.0
Falls in the last year 0.5 0.6 1.0 0.5 -1.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 -0.0 -0.8
Number of live births 7.2 10.2 10.5 -3.1 3.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.4 -0.6 0.1
Pulse rate 0.2 0.3 0.5 -0.7 0.3
Happiness 0.5 0.6 1.0 1.0 -0.3
Noisy workplace 2.3 2.8 3.0 1.6 -1.7
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 0.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.6 0.1
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 -0.2 -0.2
Asthma 0.1 0.2 0.4 -0.2 0.7
Medication: Ibuprofen (e.g. Nurofen) 3.7 4.7 9.3 3.1 -0.2
Medication: Cholesterol lowering 9.6 14.9 19.1 -3.3 4.4
Depression (self-reported) 1.2 1.4 2.7 -1.7 0.2
Medication: Lansoprazole 0.1 0.1 0.3 -0.1 0.5
Prospective memory result 0.4 0.5 0.5 0.7 -0.7
Lung cancer (father) 0.6 0.7 1.3 1.1 -0.2
Illnesses of mother 2.2 2.7 3.0 1.5 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.3 -0.5 -0.5
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.1 0.2
Impedance of arm (left) 0.3 1.2 1.6 0.9 -1.3
Arm fat mass (right) 2.9 11.8 15.5 -2.9 3.9
Trunk predicted mass 0.1 0.5 0.9 -1.0 0.3
Standing height 0.5 4.7 8.4 1.0 -2.9
Length of working week for main job 0.1 0.1 0.1 -0.3 0.0
Exposure to tobacco smoke at home 0.7 0.8 1.1 -1.0 0.8
Breastfed as a baby 1.3 1.7 3.1 -1.8 0.5
Tense / ‘highly strung’ 0.2 0.3 0.5 -0.2 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 1.0 1.0 -0.2
Hair/balding pattern: Pattern 4 0.9 2.1 2.6 -1.3 1.6
Birth weight of first child 0.5 0.9 1.0 0.9 -1.0
Peak expiratory flow (PEF) 0.7 1.6 2.3 -1.5 0.9
Pulse wave reflection index 0.4 0.5 0.9 0.2 0.9
Ever highly irritable/argumentative for 2 days 3.3 4.0 6.1 2.5 -1.4
Loud music exposure frequency 0.8 0.8 1.0 0.8 -1.0
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 3.3 -0.7 1.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.4 0.1 1.2
Blood clot in the leg (DVT) 0.5 0.6 1.1 -0.3 -1.1
Medication: Paracetamol 2.5 4.1 7.3 2.7 -0.9
Headache pain in last month 0.8 1.3 2.6 1.6 0.3
Medication for cholesterol, blood pressure or diabetes 11.8 19.6 21.7 4.2 -4.7
Glaucoma (self-reported) 0.3 0.4 0.6 0.8 0.3
Gout (self-reported) 1.2 1.7 3.3 0.3 -1.8
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.2 1.5 -0.3
Medication: Amlodipine 3.6 5.0 6.7 -2.6 1.8
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 0.1 -0.3
Birth weight 1.1 2.3 2.5 1.6 -1.4
Chronic bronchitis/emphysema (mother) 2.2 2.5 3.7 1.9 -1.2
High blood pressure (siblings) 2.1 3.0 5.7 -0.6 2.4
Forced vital capacity (FVC), Best measure 1.0 3.7 6.2 1.1 -2.5
Body fat percentage 2.9 11.3 15.2 -2.7 3.9
Leg fat percentage (right) 5.3 19.1 23.6 -3.8 4.9
Arm fat-free mass (right) 0.2 1.1 1.3 -1.1 0.9
Exposure to tobacco smoke outside home 0.4 0.6 1.1 0.0 1.1
Comparative body size at age 10 7.3 20.0 26.1 -3.7 5.1
Number of full brothers 1.3 1.6 2.2 -1.0 1.5
Worry too long after embarrassment 0.0 0.0 0.0 0.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 4.4 5.7 9.1 3.0 -1.6
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 0.3 -0.0
Number of children fathered 0.4 0.4 0.8 0.2 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 2.8 3.3 4.0 2.0 -1.6
Age at first live birth 0.0 0.1 0.1 -0.4 -0.0
Pulse wave peak to peak time 0.1 0.1 0.3 -0.0 -0.5
Health satisfaction 0.3 0.4 0.8 0.9 -0.1
Shortness of breath walking on level ground 0.6 0.7 1.3 -0.4 1.1
Qualifications: College or University degree 1.4 4.5 6.9 1.4 -2.6
Eye problems/disorders: None of the above 0.1 0.1 0.3 -0.1 -0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 1.0 0.1
Emphysema/chronic bronchitis 0.7 0.8 1.2 -1.1 0.7
Medication for pain relief, constipation, heartburn 0.8 1.4 2.6 -1.6 -0.4
Neck or shoulder pain in last month 1.1 1.6 2.4 0.9 1.6
Medication: Blood pressure 14.0 24.7 26.1 -5.1 4.8
Angina (self-reported) 2.2 2.9 4.6 -1.1 2.1
Migraine (self-reported) 0.4 0.5 1.0 1.0 -0.2
Medication: Ibuprofen 2.5 3.0 6.0 2.4 0.1
Medication: Allopurinol 0.5 0.7 1.1 0.5 -1.1
Medication: Omeprazole 0.4 0.5 0.9 0.9 0.1
Medication: Seretide 50 evohaler 0.5 0.6 1.0 -0.4 1.0
Mean time to correctly identify matches 0.0 0.1 0.1 0.3 0.3
Heart disease (mother) 0.2 0.2 0.3 0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.1 0.2 0.3
Whole body fat mass 2.9 12.3 15.2 -3.0 3.9
Leg fat mass (right) 4.0 15.5 18.5 -3.5 4.3
Arm predicted mass (right) 0.4 1.8 2.4 -1.6 1.1
Pulse rate, automated reading 0.8 2.6 4.4 -0.9 2.1
Alcohol intake frequency. 2.6 6.0 7.5 -2.1 2.7
Comparative height size at age 10 0.0 0.2 0.5 0.1 -0.7
Number of full sisters 1.2 1.4 1.8 -1.3 1.0
Suffer from ‘nerves’ 0.0 0.1 0.1 0.3 -0.2
Overall health rating 1.0 2.2 3.6 -0.9 1.9
Chest pain or discomfort 0.6 0.9 1.7 -0.3 1.3
Had major operations 0.6 0.7 0.8 0.9 -0.8
Age at last live birth 1.1 1.5 1.6 -1.3 1.2
Family relationship satisfaction 1.4 1.8 3.5 1.9 -0.2
Leg pain on walking 0.5 0.6 1.2 1.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 4.5 2.1 -0.3
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.6 -0.8 0.0
Medication: Aspirin 0.0 0.0 0.0 0.2 -0.0
Supplements: Vitamin C 0.3 0.3 0.7 -0.1 -0.8
Knee pain experienced in last month 0.1 0.1 0.2 0.1 0.5
Hypertension (Self-reported) 6.8 18.9 19.1 -4.3 4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 1.1 -0.1
Illnesses of father: Heart disease 0.9 1.2 2.1 -0.5 1.5
Illnesses of siblings: Diabetes 4.2 5.2 6.4 -2.0 2.5
Smoking status: Previous 0.8 1.2 1.3 1.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 -0.6 -0.0
Whole body fat-free mass 0.2 1.1 1.5 -1.2 0.8
Leg fat-free mass (right) 0.2 1.0 1.2 -1.1 0.8
Arm fat percentage (left) 3.7 14.7 19.6 -3.1 4.4
Average weekly red wine intake 0.7 1.0 1.5 0.8 -1.2
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.3 -0.2 -0.6
Mood swings 0.2 0.4 0.5 0.7 -0.6
Loneliness, isolation 0.1 0.2 0.2 -0.3 0.5
Long-standing illness, disability or infirmity 0.8 1.2 1.4 -1.2 1.0
Ever had bowel cancer screening 0.3 0.4 0.7 -0.2 0.8
Diabetes diagnosed by doctor 3.9 6.5 8.3 -2.2 2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.7 -0.9 0.0
Friendships satisfaction 0.9 1.1 2.2 1.5 -0.3
Qualifications: nursing, teaching 0.2 0.4 0.7 -0.2 -0.8
Commuting to job workplace: Walk 3.3 3.5 4.7 2.2 -1.5
Eye problems/disorders: Cataract 1.1 1.3 1.3 -1.1 1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.3 0.4
Medication for cholesterol 0.4 0.6 1.0 0.5 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 -0.3 0.6
Back pain experienced in last month 0.5 0.8 0.8 0.9 -0.8
Mineral and other dietary supplements 0.6 0.9 1.4 -0.6 1.2
Breast cancer (self-reported) 0.8 1.0 1.9 0.3 -1.4
Asthma (self-reported) 0.2 0.4 0.7 -0.3 0.8
Osteoporosis (self-reported) 0.2 0.2 0.2 -0.5 -0.5
Osteoarthritis (self-reported) 1.2 1.6 1.7 1.2 -1.3
Medication: Aspirin 0.1 0.1 0.2 -0.1 0.4
Medication: Gliclazide 3.9 4.5 4.9 -2.2 2.0
Illnesses of father: None of the above (group 1) 0.9 1.1 2.2 0.0 -1.5
Smoking status: Current 0.3 0.4 0.9 0.9 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.0 0.1 -0.3 0.0
Whole body water mass 0.2 1.0 1.3 -1.1 0.8
Leg predicted mass (right) 0.2 1.1 1.3 -1.1 0.9
Arm fat mass (left) 3.4 14.0 18.0 -3.1 4.2
Number of self-reported non-cancer illnesses 2.7 4.7 5.2 -2.0 2.3
Average weekly champagne plus white wine intake 1.0 1.3 1.5 1.0 -1.2
Miserableness 0.2 0.3 0.4 0.7 -0.3
Guilty feelings 2.3 3.4 5.2 2.3 -1.3
Wears glasses or contact lenses 2.5 2.9 3.2 1.8 -1.6
Ever taken oral contraceptive pill 0.5 0.5 1.1 -0.1 1.0
Hearing aid user 3.2 3.6 5.1 -1.4 2.3
Mother’s age at death 0.4 0.5 0.9 -0.3 -0.9
Financial situation satisfaction 0.3 0.3 0.4 0.6 0.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 -0.2 0.7
Commuting to job workplace: Public transport 0.5 0.6 1.2 -1.1 0.2
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 0.0 0.7
Medication: Blood pressure 3.1 5.9 6.9 -2.2 2.6
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 -0.1 0.2
Supplements: Fish oil (including cod liver oil) 1.0 1.4 2.6 0.4 -1.6
High cholesterol (Self-reported) 3.0 5.3 7.3 -1.8 2.7
Medication: Bendroflumethiazide 4.2 6.4 9.2 -3.0 1.9
Medication: Paracetamol 1.4 2.2 3.8 1.9 -0.7
Medication: Lisinopril 0.7 0.9 1.1 -1.1 0.8
Medication: Atorvastatin 0.1 0.2 0.2 -0.5 0.4
Illnesses of father: High blood pressure 4.0 4.9 7.6 -1.5 2.8
Alcohol drinker status: Never 0.5 0.6 1.0 -1.0 0.5
Ever smoked 0.5 0.8 1.0 1.0 -0.8
Basal metabolic rate 0.4 2.2 2.4 -1.5 1.4
Leg fat percentage (left) 5.1 18.4 22.7 -3.8 4.8
Arm fat-free mass (left) 0.5 2.5 2.8 -1.7 1.4
Number of operations (self-reported) 0.0 0.0 0.0 0.2 -0.2
Average weekly beer plus cider intake 1.0 1.4 1.5 1.2 -1.1
Irritability 0.3 0.5 0.6 0.8 0.6
Risk taking 1.1 1.6 2.1 1.0 -1.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.4 0.1
Fractured/broken bones in last 5 years 0.4 0.5 0.7 0.8 -0.5
Age started oral contraceptive pill 3.5 4.3 6.8 -2.6 1.4
Diastolic blood pressure, automated reading 0.2 0.7 1.2 -0.4 1.1
Ever depressed for a whole week 2.0 2.4 3.2 1.3 -1.8
Unable to work because of sickness or disability 0.9 1.1 1.3 -0.9 1.2
Commuting to job workplace: Cycle 0.0 0.0 0.0 0.0 0.2
Myopia 2.3 3.3 3.5 1.9 -1.8
Vascular/heart problems diagnosed by doctor 6.0 16.4 17.1 4.0 -4.1
Cholesterol lowering medication 1.6 2.3 4.2 -0.7 2.0
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.0 1.4 0.1
Pain experienced in last month 0.6 0.9 1.8 -1.3 -0.3
Supplements: Calcium 0.9 1.0 1.9 0.3 -1.4
Basal cell carcinoma (self-reported) 1.0 1.2 2.2 0.3 -1.5
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.8 -0.2 1.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.9 -0.6 -0.9
Heart disease (siblings) 1.8 2.2 3.9 -0.7 2.0
Alcohol drinker status: Previous 0.4 0.4 0.5 -0.7 0.7
Pack years of smoking 0.2 0.3 0.3 -0.6 0.5
Impedance of whole body 0.3 1.4 1.7 1.1 -1.3
Leg fat mass (left) 4.1 15.9 19.6 -3.5 4.4
Arm predicted mass (left) 0.4 2.0 2.3 -1.5 1.3