Hub : Genes

ZBTB48

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.5350 0.1280 0.00088 -0.012 NA 0.006 NA -0.001 8.9e-01 NA 2.2e-01 NA 3.4e-01
2 GTEx Cells Transformed fibroblasts 0.1730 0.0500 0.00012 0.058 NA 0.108 NA 0.074 3.4e-05 NA 1.7e-08 NA 3.5e-06
3 METSIM Adipose 0.0394 0.0183 0.01200 0.004 0.009 0.008 0.015 0.006 7.0e-02 0.016 1.8e-02 0.0023 3.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 5.3 8.4 10.8 -3.2 -3.3 -2.0
Bipolar Disorder or Schizophrenia 4.2 10.1 17.4 -2.1 -4.2 -2.9
Depressed Affect (Nagel 2018) 0.6 1.2 3.2 -0.2 1.8 -0.6
Depression (Nagel 2018) 1.3 2.0 4.1 1.1 0.8 -2.0
Intelligence (Savage-Jansen 2018) 0.5 1.6 4.6 2.1 0.1 -0.3
Neuroticism (Nagel 2018) 0.9 2.0 5.8 0.1 2.4 -0.5
Schizophrenia (2018) 1.6 3.4 5.4 -0.3 -2.3 -2.2
Schizophrenia vs Biploar Disorder 1.4 1.8 3.0 1.6 1.7 -0.1
Worry (Nagel 2018) 0.9 1.9 4.0 -0.3 2.0 -1.3
Alzheimer’s Disease (in mother) 0.2 0.3 0.6 0.8 -0.2 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.7 -0.7 -0.4
Alzheimer’s Disease (including proxy) 0.4 0.5 0.6 0.7 -0.8 -0.6
Crohns Disease (2017) 0.7 1.4 4.1 -2.0 -0.4 -0.1
Irritable Bowel Disease (IBD) 0.3 0.8 1.8 -1.3 0.3 0.7
Ulcerative Colitis (UC) 0.6 1.1 2.8 -0.3 0.6 1.7
Major Depression (MDD) 0.6 0.8 2.3 0.0 -0.1 -1.5
Reaction Time 1.1 2.0 5.3 -2.3 0.5 0.7
Verbal and Numeric Reasoning (VNR) 1.3 3.0 7.8 2.8 -0.0 1.2
Breast Cancer 0.0 0.1 0.1 0.3 0.0 -0.3
Ovarian Cancer 0.6 0.7 1.4 -1.2 -0.5 -0.7
Prostate Cancer 0.6 0.8 1.6 0.9 0.4 1.3
Age at First Birth 1.3 1.9 4.5 2.1 -0.9 0.6
Bipolar Disorder (2011) 0.5 0.5 1.0 0.0 -1.0 -0.7
Body Mass Index (BMI) (2010) 0.9 1.3 3.5 0.4 0.4 -1.9
Coronary Artery Disease (CAD) 0.5 0.6 1.2 -1.1 0.5 0.6
Crohns Disease (2012) 1.2 2.0 3.4 -1.9 -1.4 -0.6
Mean Putamen Volume 1.4 1.6 3.7 -0.6 -1.9 -0.8
Fasting Glucose 0.4 0.4 0.7 0.6 -0.8 0.5
HbA1C 1.5 1.7 3.9 0.4 2.0 -1.0
HDL Cholesterol 0.9 1.4 3.3 -1.8 -1.0 -0.1
LDL Cholesterol 1.2 1.9 5.5 -0.5 0.1 -2.3
Lupus 0.2 0.3 0.6 0.3 0.7 0.5
Neuroticism (2016) 0.3 0.4 0.9 -0.9 -0.3 -0.5
Primary Biliary Cirrhosis 0.2 0.3 0.6 0.0 0.8 -0.6
Rheumatoid Arthritis 0.4 0.6 1.8 -1.3 0.2 0.1
Schizophrenia (2014) 2.0 4.4 6.6 -0.6 -2.6 -2.5
Triglycerides 0.7 1.1 2.1 -1.4 -0.2 -1.1
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.8 -0.9 0.7 -0.6
Ulcerative Colitis 0.5 0.8 1.9 -0.6 1.4 0.2
Blood Eosinophil Count 0.7 5.6 10.8 1.4 2.0 -3.3
Blood Platelet Count 0.7 8.6 18.8 -0.2 2.6 -4.3
Blood Red Count 0.1 0.8 1.8 0.7 1.3 0.4
Blood White Count 0.6 4.4 10.9 -1.5 0.0 -3.3
Heel T-Score 0.8 6.4 18.0 0.8 4.2 0.8
BMI 0.5 2.9 6.3 1.3 2.5 -0.9
Height 0.5 9.4 22.8 1.8 -1.5 4.8
Waist Hip Ratio (WHR) 0.8 3.7 5.7 1.1 2.4 2.0
Systolic Blood Pressure 0.3 1.7 4.2 0.7 2.1 0.6
Smoking Status 0.6 1.3 3.7 0.0 -0.6 1.9
Allergy or Eczema 2.2 5.7 15.8 -0.5 -1.0 -4.0
Cardiovascular Disease 1.2 3.9 11.2 0.4 3.3 0.5
Hypothyroidism (self reported) 0.4 0.9 1.1 -1.0 1.0 0.8
Respiratory disease 0.7 1.5 3.8 2.0 0.9 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 0.1 0.6 -0.6
Lung FEV1/FVC ratio 2.5 12.5 26.8 2.6 5.2 2.0
Lung FVC 0.7 3.6 7.9 0.3 -1.7 2.8
Neuroticism 0.8 1.9 4.7 -1.0 2.2 0.4
Chronotype (morning person) 0.5 1.1 2.0 -1.4 -0.6 1.0
Hair Pigment 0.1 1.9 3.9 -0.6 -2.0 1.3
Tanning 0.2 2.0 3.9 -0.2 -1.5 -2.0
Hand grip strength (left) 0.2 0.5 0.9 0.6 -0.9 -0.6
Number of treatments/medications taken 0.4 0.8 1.5 -1.2 0.6 -0.7
Average weekly spirits intake 0.5 0.6 1.1 0.7 0.5 -1.0
Sensitivity / hurt feelings 1.0 1.7 4.8 0.3 2.2 0.3
Frequency of depressed mood in last 2 weeks 2.0 2.8 7.6 -0.8 0.3 -2.8
Hearing difficulty/problems: Yes 0.9 1.4 3.9 -2.0 -0.2 -0.5
Relative age of first facial hair 1.2 2.4 5.4 -2.3 -1.1 0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.4 0.6 -0.6 1.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 -0.6 0.0 -1.1
Ever had hysterectomy (womb removed) 1.1 1.2 2.7 -0.8 0.6 -1.6
Systolic blood pressure, automated reading 0.5 1.5 3.7 -0.1 1.9 0.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.1 0.4 -0.1
Angina 0.6 0.7 1.2 -0.4 1.1 -0.9
Medication for hormone replacement therapy 1.7 1.8 3.6 -1.2 -0.6 -1.9
Vitamin and mineral supplements 1.4 1.9 2.8 -1.1 1.7 1.3
Supplements: Zinc 2.2 2.4 5.5 0.3 -2.3 -1.2
Medication: Co-codamol 2.9 3.4 10.0 0.4 3.2 0.2
Medication: Metformin 0.0 0.1 0.1 0.2 -0.3 -0.2
Diabetes (father) 0.5 0.6 1.5 -1.2 0.3 0.4
Diabetes (mother) 1.5 1.9 4.3 1.1 2.1 -0.1
Severe depression (siblings) 0.6 0.7 1.9 0.5 0.1 -1.4
Pack years adult smoking proportion 0.2 0.3 0.4 -0.6 0.3 0.6
Impedance of leg (right) 0.7 3.2 5.2 -1.5 2.3 1.5
Leg fat-free mass (left) 0.4 1.9 3.1 1.8 -0.2 1.6
Trunk fat percentage 0.7 2.8 7.4 -0.5 2.7 0.8
Hand grip strength (right) 0.3 0.8 1.4 0.5 -1.2 -0.8
Townsend deprivation index at recruitment 1.5 2.1 5.9 0.6 0.1 2.4
Current tobacco smoking 0.3 0.5 0.6 0.7 -0.8 0.5
Average weekly fortified wine intake 0.3 0.3 0.6 0.8 -0.2 0.5
Maternal smoking around birth 1.0 1.4 3.0 1.7 1.0 0.4
Fed-up feelings 0.7 1.3 1.7 -1.2 1.3 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 4.8 -0.7 -0.2 -2.2
Relative age voice broke 0.3 0.5 0.8 0.8 -0.1 0.9
Taking other prescription medications 0.6 1.0 1.6 -0.4 1.1 1.2
Age when periods started (menarche) 0.1 0.2 0.3 -0.3 -0.5 0.4
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.2 1.5 0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.6 -0.1 1.6 -0.2
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 0.3 0.7 0.2
Qualifications: CSEs or equivalent 2.4 3.2 8.0 1.2 0.4 -2.8
Serious illness, injury or assault to yourself 1.0 1.2 3.1 0.5 -1.8 -0.2
High blood pressure 0.9 2.6 6.3 -1.3 2.5 -0.1
Hayfever, allergic rhinitis or eczema 1.8 4.0 10.9 0.4 -1.0 -3.3
Multivitamins +/- minerals 2.9 3.7 8.6 0.0 -2.9 -1.5
Stomach or abdominal pain in last month 0.5 0.7 1.8 -1.4 0.3 0.3
Supplements: Glucosamine 1.3 1.7 2.9 -1.1 -1.7 -1.1
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.5 1.9 1.4 0.1
Medication: Atenolol 4.2 5.3 14.3 1.0 3.8 0.7
Medication: Levothyroxine sodium 0.5 0.9 1.5 -1.2 0.7 0.8
Sitting height 0.5 3.7 9.5 1.3 -0.2 3.1
Chronic bronchitis/emphysema (father) 0.4 0.4 1.2 -1.1 -0.2 0.1
High blood pressure (mother) 1.9 2.7 6.6 0.7 2.6 1.0
Body mass index (BMI) 0.4 1.8 5.2 0.6 2.3 0.0
Impedance of leg (left) 0.7 3.6 5.5 -1.9 2.4 1.3
Leg predicted mass (left) 0.3 1.8 3.0 1.7 -0.1 1.6
Trunk fat mass 0.6 2.6 5.9 0.3 2.4 1.3
Waist circumference 1.1 4.0 8.1 0.8 2.8 1.8
Number of incorrect matches in round 0.5 0.9 1.7 -1.3 0.9 -0.3
Past tobacco smoking 1.5 2.7 5.9 1.2 -0.9 -2.4
Alcohol usually taken with meals 0.4 0.7 1.3 0.8 0.1 1.2
Nervous feelings 0.5 0.9 2.2 0.5 1.5 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.2 -0.7 0.8 -1.5
Hearing difficulty/problems with background noise 1.8 2.9 6.1 -2.5 -1.6 -0.3
Hair/balding pattern: Pattern 2 0.9 1.2 1.7 -0.9 1.1 1.3
Had menopause 0.6 0.7 2.0 -0.5 -1.4 0.1
Had other major operations 0.6 0.8 1.7 1.3 -0.4 -0.6
Forced vital capacity (FVC) 1.2 4.5 7.3 1.4 -2.1 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.0 -0.8 1.0 -0.5
Ever unenthusiastic/disinterested for a whole week 1.5 1.9 3.8 -0.6 -1.2 -1.9
Qualifications: None of the above 2.2 4.7 12.4 -0.7 3.5 1.0
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.0 -0.5 -0.3
Mouth/teeth dental problems 0.4 0.7 0.7 0.9 0.8 0.8
Heart attack 0.2 0.2 0.3 0.1 0.6 -0.5
Allergy 1.6 3.6 9.9 -0.9 0.5 3.1
Pain all over the body in last month 0.5 0.5 1.0 0.3 1.0 -0.6
Diabetes (self-reported) 0.5 0.7 1.1 0.6 1.0 0.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.1 1.4 -1.1 1.0
Medication: Ramipril 0.6 0.7 1.6 0.7 0.4 1.2
Medication: Simvastatin 0.7 1.1 3.1 0.3 1.8 -0.0
Fluid intelligence score 0.6 1.3 2.8 1.7 -1.0 0.4
Illnesses of siblings 3.0 4.2 8.6 2.0 -2.9 0.2
Neuroticism score 1.2 2.5 3.7 -1.9 1.8 -0.6
Weight 0.6 2.8 3.8 1.3 1.7 1.9
Impedance of arm (right) 0.1 0.2 0.4 -0.2 0.6 0.6
Arm fat percentage (right) 0.6 2.2 6.1 0.3 2.5 0.6
Trunk fat-free mass 0.4 2.5 4.9 1.6 -0.2 2.2
Hip circumference 0.8 3.4 5.2 0.8 2.1 2.3
Time employed in main current job 1.0 1.2 3.3 -0.4 -0.3 -1.8
Alcohol intake versus 10 years previously 0.6 0.9 1.3 1.2 0.3 -1.1
Father’s age at death 1.1 1.5 3.4 0.9 -1.8 0.6
Worrier / anxious feelings 2.5 4.8 9.2 -1.7 3.0 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 -1.2 0.7 -0.6
Falls in the last year 0.8 1.0 2.5 -0.7 -1.6 -0.1
Hair/balding pattern: Pattern 3 0.6 0.9 1.9 1.4 0.9 0.3
Number of live births 0.5 0.7 1.8 -1.3 0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 1.3 4.5 8.9 2.1 -0.4 3.0
Pulse rate 0.1 0.2 0.4 -0.4 -0.7 0.3
Happiness 0.2 0.3 0.6 -0.2 0.4 -0.8
Noisy workplace 0.7 0.9 2.0 -1.4 0.7 0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 0.1 -0.8 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 3.0 -0.7 -1.7 -0.2
Mouth/teeth dental problems: Dentures 0.9 1.5 3.0 -1.1 -0.5 1.7
Asthma 0.8 1.6 3.6 1.9 1.0 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.1 -0.9 -1.4 -1.8
Medication: Cholesterol lowering 0.9 1.4 2.8 -0.5 1.7 -1.0
Depression (self-reported) 0.6 0.7 0.9 0.9 0.6 0.9
Medication: Lansoprazole 0.9 1.1 2.8 -1.7 0.4 0.5
Prospective memory result 1.2 1.4 2.5 1.3 1.6 0.3
Lung cancer (father) 0.8 0.9 2.2 0.8 0.1 -1.5
Illnesses of mother 0.2 0.2 0.7 -0.8 0.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.1 9.3 2.9 0.5 3.1
Pulse wave Arterial Stiffness index 5.3 6.2 15.0 3.9 0.7 1.8
Impedance of arm (left) 0.1 0.3 0.5 -0.7 0.5 0.4
Arm fat mass (right) 0.5 2.0 4.5 0.7 2.1 1.0
Trunk predicted mass 0.5 2.6 5.1 1.6 -0.3 2.2
Standing height 0.6 5.6 14.0 1.2 -1.2 3.7
Length of working week for main job 0.3 0.3 0.9 0.1 0.9 -0.4
Exposure to tobacco smoke at home 0.4 0.4 0.7 0.1 0.8 0.8
Breastfed as a baby 0.4 0.4 0.6 -0.6 -0.8 0.6
Tense / ‘highly strung’ 0.1 0.2 0.4 0.3 0.4 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 -0.1 0.1 -1.0
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 0.4 -0.1 0.8
Birth weight of first child 0.9 1.6 4.2 -0.6 -2.0 -0.4
Peak expiratory flow (PEF) 1.5 3.5 8.1 2.9 1.3 0.8
Pulse wave reflection index 1.9 2.3 6.2 2.5 -0.6 0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.0 -0.4 -0.6 -1.0
Loud music exposure frequency 0.5 0.6 1.5 -0.2 -1.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.4 -1.1 -1.2 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.1 0.6 -1.1
Blood clot in the leg (DVT) 1.0 1.3 3.0 -0.3 -0.9 -1.7
Medication: Paracetamol 0.4 0.7 2.1 -0.1 0.3 -1.4
Headache pain in last month 0.8 1.3 2.1 -0.2 1.3 -1.4
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.2 0.0 -1.5 0.4
Glaucoma (self-reported) 2.3 2.7 4.7 -1.7 -2.2 -0.9
Gout (self-reported) 1.2 1.7 4.6 0.4 2.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.3 -1.1 1.1 0.7
Medication: Amlodipine 0.3 0.4 0.5 0.6 0.7 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.3 0.7 1.5 -0.3
Birth weight 1.4 2.9 5.9 2.4 -1.4 1.0
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.3 -1.5 -0.7 -1.4
High blood pressure (siblings) 1.5 2.2 4.4 -2.1 1.2 -0.9
Forced vital capacity (FVC), Best measure 1.2 4.4 7.4 2.3 -0.8 2.7
Body fat percentage 1.0 4.0 10.8 -0.2 3.3 1.1
Leg fat percentage (right) 2.1 7.5 19.0 0.3 4.4 1.8
Arm fat-free mass (right) 0.3 1.3 3.0 0.9 -0.1 1.7
Exposure to tobacco smoke outside home 1.0 1.4 3.0 -1.7 1.1 -0.0
Comparative body size at age 10 1.1 2.9 7.3 -0.7 -1.0 -2.7
Number of full brothers 1.2 1.5 3.6 -0.9 1.9 -0.2
Worry too long after embarrassment 0.9 1.5 2.4 -1.6 1.4 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.9 -0.0 -0.1
Wheeze or whistling in the chest in last year 0.9 1.5 2.8 -1.7 -0.7 -1.2
Number of children fathered 1.3 1.5 3.1 -0.7 1.8 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.4 1.2 0.3 -0.6
Age at first live birth 1.4 2.6 5.7 -1.2 -2.4 -0.7
Pulse wave peak to peak time 4.2 4.9 12.1 -3.5 -0.8 -1.4
Health satisfaction 0.8 1.0 1.7 -0.2 1.3 1.2
Shortness of breath walking on level ground 2.3 2.7 4.4 -1.8 0.6 2.1
Qualifications: College or University degree 0.7 2.2 6.3 0.1 -2.5 0.4
Eye problems/disorders: None of the above 3.6 4.1 5.6 2.4 2.3 1.2
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.3 -0.2 0.3 -1.1
Emphysema/chronic bronchitis 1.4 1.6 4.5 -2.1 -0.4 0.3
Medication for pain relief, constipation, heartburn 1.1 1.9 3.1 1.5 -0.4 1.8
Neck or shoulder pain in last month 1.0 1.5 2.1 0.5 1.4 -1.4
Medication: Blood pressure 0.5 0.9 1.7 -0.9 1.3 -0.4
Angina (self-reported) 0.8 1.1 1.8 -0.3 1.1 -1.4
Migraine (self-reported) 0.8 1.0 2.9 -0.2 -1.7 0.4
Medication: Ibuprofen 0.9 1.0 1.9 -0.4 -1.4 -1.0
Medication: Allopurinol 1.0 1.4 3.3 -0.5 1.8 0.7
Medication: Omeprazole 1.3 1.5 3.1 -1.1 1.8 -0.5
Medication: Seretide 50 evohaler 3.1 3.6 6.1 -2.0 -0.7 -2.5
Mean time to correctly identify matches 1.0 1.9 5.3 -2.3 0.6 0.3
Heart disease (mother) 0.5 0.6 1.8 -1.4 -0.0 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 3.2 1.8 1.1 -1.5
Whole body fat mass 0.7 2.8 6.4 0.3 2.5 1.4
Leg fat mass (right) 1.1 4.3 9.1 0.4 3.0 1.9
Arm predicted mass (right) 0.2 1.1 2.7 0.8 -0.3 1.6
Pulse rate, automated reading 0.2 0.7 1.8 -1.4 0.1 -0.5
Alcohol intake frequency. 0.4 0.9 2.5 -0.0 0.3 -1.6
Comparative height size at age 10 0.5 2.7 6.6 1.2 -0.4 2.6
Number of full sisters 2.1 2.6 4.3 -2.1 -1.7 0.8
Suffer from ‘nerves’ 0.2 0.4 0.7 -0.9 -0.1 -0.6
Overall health rating 0.7 1.5 4.4 -0.2 2.1 -0.2
Chest pain or discomfort 0.6 0.8 1.7 -0.7 1.3 0.6
Had major operations 0.1 0.1 0.2 -0.4 -0.3 0.1
Age at last live birth 1.9 2.8 5.3 -0.7 -2.3 -1.6
Family relationship satisfaction 0.7 0.8 1.6 1.2 -0.6 -0.8
Leg pain on walking 0.9 1.1 2.7 -1.6 0.6 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.9 -1.0 -0.1 -1.7
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 -0.7 0.3 0.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.2 -1.1 0.8 -0.6
Medication: Aspirin 0.4 0.6 1.6 -1.3 -0.3 -0.1
Supplements: Vitamin C 1.2 1.4 4.0 2.0 -0.3 0.3
Knee pain experienced in last month 0.9 1.4 2.9 -1.0 -0.6 -1.7
Hypertension (Self-reported) 1.1 3.0 7.5 -1.3 2.7 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 5.0 -2.2 0.4 0.7
Illnesses of father: Heart disease 1.3 1.8 2.6 -0.7 1.5 -1.6
Illnesses of siblings: Diabetes 1.6 1.9 4.1 2.0 0.4 1.3
Smoking status: Previous 1.6 2.4 3.3 -1.6 1.1 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.4 0.6 -0.7 0.4
Whole body fat-free mass 0.3 2.0 3.5 1.5 -0.3 1.9
Leg fat-free mass (right) 0.3 1.4 2.1 1.4 -0.4 1.4
Arm fat percentage (left) 0.6 2.2 6.2 0.2 2.5 0.5
Average weekly red wine intake 0.5 0.7 1.0 -1.0 -0.9 0.5
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 0.0 -0.7 0.8
Mood swings 0.2 0.4 1.1 -1.1 0.2 -0.1
Loneliness, isolation 0.5 0.7 2.0 -0.0 -0.5 -1.4
Long-standing illness, disability or infirmity 0.3 0.5 0.8 0.9 -0.0 0.9
Ever had bowel cancer screening 0.4 0.5 1.2 -0.4 -0.3 -1.1
Diabetes diagnosed by doctor 0.5 0.8 1.3 1.1 0.8 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.7 -1.0 1.3 -0.0
Friendships satisfaction 0.5 0.7 1.5 0.4 -1.2 -0.6
Qualifications: nursing, teaching 0.4 0.6 1.5 1.2 -0.4 0.2
Commuting to job workplace: Walk 0.9 1.0 2.9 0.2 0.4 1.7
Eye problems/disorders: Cataract 2.5 2.8 3.5 -1.8 -1.9 -1.3
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 4.6 -1.9 0.5 -2.1
Medication for cholesterol 0.6 0.9 1.6 0.9 -1.3 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 3.5 -1.5 1.1 -1.9
Back pain experienced in last month 1.4 2.1 3.5 0.7 1.5 1.9
Mineral and other dietary supplements 2.5 3.4 5.5 1.0 1.9 2.3
Breast cancer (self-reported) 1.2 1.4 2.9 1.2 0.1 1.7
Asthma (self-reported) 1.0 2.0 4.0 2.0 1.3 -0.4
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.2 -1.0 -0.8
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.1 -0.4 -0.7
Medication: Aspirin 0.3 0.3 0.8 -0.9 -0.3 -0.4
Medication: Gliclazide 3.3 3.7 7.2 -2.7 0.2 -1.9
Illnesses of father: None of the above (group 1) 2.1 2.5 7.2 2.7 -0.6 0.4
Smoking status: Current 0.3 0.5 1.1 0.3 -1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 5.5 2.3 1.0 0.6
Whole body water mass 0.3 1.7 2.9 1.5 -0.4 1.7
Leg predicted mass (right) 0.3 1.5 2.3 1.5 -0.5 1.4
Arm fat mass (left) 0.4 1.6 3.6 0.7 1.9 0.8
Number of self-reported non-cancer illnesses 0.6 1.0 1.6 -0.4 1.3 1.1
Average weekly champagne plus white wine intake 1.2 1.7 4.1 2.0 -0.1 0.9
Miserableness 1.1 2.0 4.1 -0.8 2.0 -1.1
Guilty feelings 0.4 0.6 1.3 -0.7 1.1 0.1
Wears glasses or contact lenses 0.5 0.5 0.8 0.9 0.6 0.7
Ever taken oral contraceptive pill 0.3 0.3 0.5 0.2 -0.7 -0.7
Hearing aid user 0.4 0.4 1.0 -0.5 1.0 -0.2
Mother’s age at death 1.0 1.2 3.6 0.3 -1.9 -0.1
Financial situation satisfaction 0.2 0.2 0.2 -0.4 -0.4 0.4
Tinnitus: Yes, now most or all of the time 2.2 2.5 4.7 -2.2 -1.7 -0.0
Commuting to job workplace: Public transport 0.7 0.8 2.1 0.6 -0.3 1.4
Eye problems/disorders: Glaucoma 1.7 2.0 3.3 -1.8 -1.7 -0.2
Medication: Blood pressure 1.0 2.0 3.8 -0.5 1.9 1.4
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.6 -1.6 1.0 0.2
Supplements: Fish oil (including cod liver oil) 1.1 1.4 1.7 -1.2 -1.3 -1.1
High cholesterol (Self-reported) 1.3 2.3 4.8 1.3 2.2 0.4
Medication: Bendroflumethiazide 0.8 1.2 2.6 -1.0 1.6 -0.3
Medication: Paracetamol 0.5 0.7 2.0 -0.3 -0.1 -1.4
Medication: Lisinopril 1.5 2.0 3.0 -0.5 1.6 1.7
Medication: Atorvastatin 0.5 0.6 1.1 0.4 0.7 -1.1
Illnesses of father: High blood pressure 1.1 1.4 3.4 -1.9 0.6 0.6
Alcohol drinker status: Never 0.7 0.9 1.4 -0.2 -1.1 1.2
Ever smoked 0.9 1.6 3.5 -0.4 1.2 1.9
Basal metabolic rate 0.3 1.9 3.6 1.4 0.2 1.9
Leg fat percentage (left) 2.0 7.1 18.4 0.4 4.3 1.6
Arm fat-free mass (left) 0.3 1.5 3.5 1.0 -0.1 1.9
Number of operations (self-reported) 1.5 2.2 6.0 0.3 -2.5 -0.6
Average weekly beer plus cider intake 0.6 0.9 2.3 -1.5 0.2 -0.6
Irritability 2.3 3.9 4.5 1.6 2.1 -2.1
Risk taking 1.5 2.2 5.7 -0.1 -2.4 0.9
Ever had prostate specific antigen (PSA) test 1.1 1.2 3.3 1.8 0.6 0.2
Fractured/broken bones in last 5 years 1.4 1.8 3.1 -1.8 1.1 -1.1
Age started oral contraceptive pill 0.9 1.1 1.5 -1.1 -1.2 0.7
Diastolic blood pressure, automated reading 0.4 1.2 2.2 -1.5 0.4 1.1
Ever depressed for a whole week 1.0 1.2 2.4 -1.0 -1.5 -0.6
Unable to work because of sickness or disability 1.3 1.7 2.9 -1.1 -1.7 1.1
Commuting to job workplace: Cycle 1.6 1.9 4.4 1.1 -0.3 2.1
Myopia 1.3 1.9 3.4 -1.2 -1.8 -1.0
Vascular/heart problems diagnosed by doctor 1.3 3.6 9.9 1.0 -3.1 0.2
Cholesterol lowering medication 1.7 2.5 6.9 0.8 2.6 0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.6 -1.9 1.1 0.0
Pain experienced in last month 0.7 1.2 3.5 0.4 -1.9 0.1
Supplements: Calcium 2.9 3.2 6.2 -0.9 -2.5 1.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 1.1 0.5 -0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.3 0.2 1.1 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.4 -0.6 -0.6 -1.6
Heart disease (siblings) 2.9 3.6 10.7 0.1 3.3 0.0
Alcohol drinker status: Previous 0.6 0.7 1.4 -0.9 -0.3 -1.2
Pack years of smoking 0.3 0.5 0.8 -0.9 0.4 0.6
Impedance of whole body 0.2 1.2 2.0 -1.4 1.1 0.8
Leg fat mass (left) 1.0 3.7 8.5 0.3 2.9 1.6
Arm predicted mass (left) 0.3 1.4 3.3 0.9 0.0 1.8