Hub : Genes

ZBTB48

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.5350	0.1280	0.00088	-0.012	NA	0.006	NA	-0.001	8.9e-01	NA	2.2e-01	NA	3.4e-01
2	GTEx	Cells Transformed fibroblasts	0.1730	0.0500	0.00012	0.058	NA	0.108	NA	0.074	3.4e-05	NA	1.7e-08	NA	3.5e-06
3	METSIM	Adipose	0.0394	0.0183	0.01200	0.004	0.009	0.008	0.015	0.006	7.0e-02	0.016	1.8e-02	0.0023	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	5.3	8.4	10.8	-3.2	-3.3	-2.0
Bipolar Disorder or Schizophrenia	4.2	10.1	17.4	-2.1	-4.2	-2.9
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	-0.2	1.8	-0.6
Depression (Nagel 2018)	1.3	2.0	4.1	1.1	0.8	-2.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.6	2.1	0.1	-0.3
Neuroticism (Nagel 2018)	0.9	2.0	5.8	0.1	2.4	-0.5
Schizophrenia (2018)	1.6	3.4	5.4	-0.3	-2.3	-2.2
Schizophrenia vs Biploar Disorder	1.4	1.8	3.0	1.6	1.7	-0.1
Worry (Nagel 2018)	0.9	1.9	4.0	-0.3	2.0	-1.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.8	-0.2	-0.4
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.7	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	0.6	0.7	-0.8	-0.6
Crohns Disease (2017)	0.7	1.4	4.1	-2.0	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	-1.3	0.3	0.7
Ulcerative Colitis (UC)	0.6	1.1	2.8	-0.3	0.6	1.7
Major Depression (MDD)	0.6	0.8	2.3	0.0	-0.1	-1.5
Reaction Time	1.1	2.0	5.3	-2.3	0.5	0.7
Verbal and Numeric Reasoning (VNR)	1.3	3.0	7.8	2.8	-0.0	1.2
Breast Cancer	0.0	0.1	0.1	0.3	0.0	-0.3
Ovarian Cancer	0.6	0.7	1.4	-1.2	-0.5	-0.7
Prostate Cancer	0.6	0.8	1.6	0.9	0.4	1.3
Age at First Birth	1.3	1.9	4.5	2.1	-0.9	0.6
Bipolar Disorder (2011)	0.5	0.5	1.0	0.0	-1.0	-0.7
Body Mass Index (BMI) (2010)	0.9	1.3	3.5	0.4	0.4	-1.9
Coronary Artery Disease (CAD)	0.5	0.6	1.2	-1.1	0.5	0.6
Crohns Disease (2012)	1.2	2.0	3.4	-1.9	-1.4	-0.6
Mean Putamen Volume	1.4	1.6	3.7	-0.6	-1.9	-0.8
Fasting Glucose	0.4	0.4	0.7	0.6	-0.8	0.5
HbA1C	1.5	1.7	3.9	0.4	2.0	-1.0
HDL Cholesterol	0.9	1.4	3.3	-1.8	-1.0	-0.1
LDL Cholesterol	1.2	1.9	5.5	-0.5	0.1	-2.3
Lupus	0.2	0.3	0.6	0.3	0.7	0.5
Neuroticism (2016)	0.3	0.4	0.9	-0.9	-0.3	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.0	0.8	-0.6
Rheumatoid Arthritis	0.4	0.6	1.8	-1.3	0.2	0.1
Schizophrenia (2014)	2.0	4.4	6.6	-0.6	-2.6	-2.5
Triglycerides	0.7	1.1	2.1	-1.4	-0.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.8	-0.9	0.7	-0.6
Ulcerative Colitis	0.5	0.8	1.9	-0.6	1.4	0.2
Blood Eosinophil Count	0.7	5.6	10.8	1.4	2.0	-3.3
Blood Platelet Count	0.7	8.6	18.8	-0.2	2.6	-4.3
Blood Red Count	0.1	0.8	1.8	0.7	1.3	0.4
Blood White Count	0.6	4.4	10.9	-1.5	0.0	-3.3
Heel T-Score	0.8	6.4	18.0	0.8	4.2	0.8
BMI	0.5	2.9	6.3	1.3	2.5	-0.9
Height	0.5	9.4	22.8	1.8	-1.5	4.8
Waist Hip Ratio (WHR)	0.8	3.7	5.7	1.1	2.4	2.0
Systolic Blood Pressure	0.3	1.7	4.2	0.7	2.1	0.6
Smoking Status	0.6	1.3	3.7	0.0	-0.6	1.9
Allergy or Eczema	2.2	5.7	15.8	-0.5	-1.0	-4.0
Cardiovascular Disease	1.2	3.9	11.2	0.4	3.3	0.5
Hypothyroidism (self reported)	0.4	0.9	1.1	-1.0	1.0	0.8
Respiratory disease	0.7	1.5	3.8	2.0	0.9	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.1	0.6	-0.6
Lung FEV1/FVC ratio	2.5	12.5	26.8	2.6	5.2	2.0
Lung FVC	0.7	3.6	7.9	0.3	-1.7	2.8
Neuroticism	0.8	1.9	4.7	-1.0	2.2	0.4
Chronotype (morning person)	0.5	1.1	2.0	-1.4	-0.6	1.0
Hair Pigment	0.1	1.9	3.9	-0.6	-2.0	1.3
Tanning	0.2	2.0	3.9	-0.2	-1.5	-2.0
Hand grip strength (left)	0.2	0.5	0.9	0.6	-0.9	-0.6
Number of treatments/medications taken	0.4	0.8	1.5	-1.2	0.6	-0.7
Average weekly spirits intake	0.5	0.6	1.1	0.7	0.5	-1.0
Sensitivity / hurt feelings	1.0	1.7	4.8	0.3	2.2	0.3
Frequency of depressed mood in last 2 weeks	2.0	2.8	7.6	-0.8	0.3	-2.8
Hearing difficulty/problems: Yes	0.9	1.4	3.9	-2.0	-0.2	-0.5
Relative age of first facial hair	1.2	2.4	5.4	-2.3	-1.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	0.6	-0.6	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.6	0.0	-1.1
Ever had hysterectomy (womb removed)	1.1	1.2	2.7	-0.8	0.6	-1.6
Systolic blood pressure, automated reading	0.5	1.5	3.7	-0.1	1.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.1	0.4	-0.1
Angina	0.6	0.7	1.2	-0.4	1.1	-0.9
Medication for hormone replacement therapy	1.7	1.8	3.6	-1.2	-0.6	-1.9
Vitamin and mineral supplements	1.4	1.9	2.8	-1.1	1.7	1.3
Supplements: Zinc	2.2	2.4	5.5	0.3	-2.3	-1.2
Medication: Co-codamol	2.9	3.4	10.0	0.4	3.2	0.2
Medication: Metformin	0.0	0.1	0.1	0.2	-0.3	-0.2
Diabetes (father)	0.5	0.6	1.5	-1.2	0.3	0.4
Diabetes (mother)	1.5	1.9	4.3	1.1	2.1	-0.1
Severe depression (siblings)	0.6	0.7	1.9	0.5	0.1	-1.4
Pack years adult smoking proportion	0.2	0.3	0.4	-0.6	0.3	0.6
Impedance of leg (right)	0.7	3.2	5.2	-1.5	2.3	1.5
Leg fat-free mass (left)	0.4	1.9	3.1	1.8	-0.2	1.6
Trunk fat percentage	0.7	2.8	7.4	-0.5	2.7	0.8
Hand grip strength (right)	0.3	0.8	1.4	0.5	-1.2	-0.8
Townsend deprivation index at recruitment	1.5	2.1	5.9	0.6	0.1	2.4
Current tobacco smoking	0.3	0.5	0.6	0.7	-0.8	0.5
Average weekly fortified wine intake	0.3	0.3	0.6	0.8	-0.2	0.5
Maternal smoking around birth	1.0	1.4	3.0	1.7	1.0	0.4
Fed-up feelings	0.7	1.3	1.7	-1.2	1.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.8	-0.7	-0.2	-2.2
Relative age voice broke	0.3	0.5	0.8	0.8	-0.1	0.9
Taking other prescription medications	0.6	1.0	1.6	-0.4	1.1	1.2
Age when periods started (menarche)	0.1	0.2	0.3	-0.3	-0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.2	1.5	0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.6	-0.1	1.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.3	0.7	0.2
Qualifications: CSEs or equivalent	2.4	3.2	8.0	1.2	0.4	-2.8
Serious illness, injury or assault to yourself	1.0	1.2	3.1	0.5	-1.8	-0.2
High blood pressure	0.9	2.6	6.3	-1.3	2.5	-0.1
Hayfever, allergic rhinitis or eczema	1.8	4.0	10.9	0.4	-1.0	-3.3
Multivitamins +/- minerals	2.9	3.7	8.6	0.0	-2.9	-1.5
Stomach or abdominal pain in last month	0.5	0.7	1.8	-1.4	0.3	0.3
Supplements: Glucosamine	1.3	1.7	2.9	-1.1	-1.7	-1.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.5	1.9	1.4	0.1
Medication: Atenolol	4.2	5.3	14.3	1.0	3.8	0.7
Medication: Levothyroxine sodium	0.5	0.9	1.5	-1.2	0.7	0.8
Sitting height	0.5	3.7	9.5	1.3	-0.2	3.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-1.1	-0.2	0.1
High blood pressure (mother)	1.9	2.7	6.6	0.7	2.6	1.0
Body mass index (BMI)	0.4	1.8	5.2	0.6	2.3	0.0
Impedance of leg (left)	0.7	3.6	5.5	-1.9	2.4	1.3
Leg predicted mass (left)	0.3	1.8	3.0	1.7	-0.1	1.6
Trunk fat mass	0.6	2.6	5.9	0.3	2.4	1.3
Waist circumference	1.1	4.0	8.1	0.8	2.8	1.8
Number of incorrect matches in round	0.5	0.9	1.7	-1.3	0.9	-0.3
Past tobacco smoking	1.5	2.7	5.9	1.2	-0.9	-2.4
Alcohol usually taken with meals	0.4	0.7	1.3	0.8	0.1	1.2
Nervous feelings	0.5	0.9	2.2	0.5	1.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	-0.7	0.8	-1.5
Hearing difficulty/problems with background noise	1.8	2.9	6.1	-2.5	-1.6	-0.3
Hair/balding pattern: Pattern 2	0.9	1.2	1.7	-0.9	1.1	1.3
Had menopause	0.6	0.7	2.0	-0.5	-1.4	0.1
Had other major operations	0.6	0.8	1.7	1.3	-0.4	-0.6
Forced vital capacity (FVC)	1.2	4.5	7.3	1.4	-2.1	2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.0	-0.8	1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.8	-0.6	-1.2	-1.9
Qualifications: None of the above	2.2	4.7	12.4	-0.7	3.5	1.0
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.0	-0.5	-0.3
Mouth/teeth dental problems	0.4	0.7	0.7	0.9	0.8	0.8
Heart attack	0.2	0.2	0.3	0.1	0.6	-0.5
Allergy	1.6	3.6	9.9	-0.9	0.5	3.1
Pain all over the body in last month	0.5	0.5	1.0	0.3	1.0	-0.6
Diabetes (self-reported)	0.5	0.7	1.1	0.6	1.0	0.9
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.1	1.4	-1.1	1.0
Medication: Ramipril	0.6	0.7	1.6	0.7	0.4	1.2
Medication: Simvastatin	0.7	1.1	3.1	0.3	1.8	-0.0
Fluid intelligence score	0.6	1.3	2.8	1.7	-1.0	0.4
Illnesses of siblings	3.0	4.2	8.6	2.0	-2.9	0.2
Neuroticism score	1.2	2.5	3.7	-1.9	1.8	-0.6
Weight	0.6	2.8	3.8	1.3	1.7	1.9
Impedance of arm (right)	0.1	0.2	0.4	-0.2	0.6	0.6
Arm fat percentage (right)	0.6	2.2	6.1	0.3	2.5	0.6
Trunk fat-free mass	0.4	2.5	4.9	1.6	-0.2	2.2
Hip circumference	0.8	3.4	5.2	0.8	2.1	2.3
Time employed in main current job	1.0	1.2	3.3	-0.4	-0.3	-1.8
Alcohol intake versus 10 years previously	0.6	0.9	1.3	1.2	0.3	-1.1
Father’s age at death	1.1	1.5	3.4	0.9	-1.8	0.6
Worrier / anxious feelings	2.5	4.8	9.2	-1.7	3.0	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-1.2	0.7	-0.6
Falls in the last year	0.8	1.0	2.5	-0.7	-1.6	-0.1
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	1.4	0.9	0.3
Number of live births	0.5	0.7	1.8	-1.3	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	8.9	2.1	-0.4	3.0
Pulse rate	0.1	0.2	0.4	-0.4	-0.7	0.3
Happiness	0.2	0.3	0.6	-0.2	0.4	-0.8
Noisy workplace	0.7	0.9	2.0	-1.4	0.7	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.1	-0.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.0	-0.7	-1.7	-0.2
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.1	-0.5	1.7
Asthma	0.8	1.6	3.6	1.9	1.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.1	-0.9	-1.4	-1.8
Medication: Cholesterol lowering	0.9	1.4	2.8	-0.5	1.7	-1.0
Depression (self-reported)	0.6	0.7	0.9	0.9	0.6	0.9
Medication: Lansoprazole	0.9	1.1	2.8	-1.7	0.4	0.5
Prospective memory result	1.2	1.4	2.5	1.3	1.6	0.3
Lung cancer (father)	0.8	0.9	2.2	0.8	0.1	-1.5
Illnesses of mother	0.2	0.2	0.7	-0.8	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	9.3	2.9	0.5	3.1
Pulse wave Arterial Stiffness index	5.3	6.2	15.0	3.9	0.7	1.8
Impedance of arm (left)	0.1	0.3	0.5	-0.7	0.5	0.4
Arm fat mass (right)	0.5	2.0	4.5	0.7	2.1	1.0
Trunk predicted mass	0.5	2.6	5.1	1.6	-0.3	2.2
Standing height	0.6	5.6	14.0	1.2	-1.2	3.7
Length of working week for main job	0.3	0.3	0.9	0.1	0.9	-0.4
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.1	0.8	0.8
Breastfed as a baby	0.4	0.4	0.6	-0.6	-0.8	0.6
Tense / ‘highly strung’	0.1	0.2	0.4	0.3	0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.1	0.1	-1.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.4	-0.1	0.8
Birth weight of first child	0.9	1.6	4.2	-0.6	-2.0	-0.4
Peak expiratory flow (PEF)	1.5	3.5	8.1	2.9	1.3	0.8
Pulse wave reflection index	1.9	2.3	6.2	2.5	-0.6	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.4	-0.6	-1.0
Loud music exposure frequency	0.5	0.6	1.5	-0.2	-1.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.4	-1.1	-1.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.1	0.6	-1.1
Blood clot in the leg (DVT)	1.0	1.3	3.0	-0.3	-0.9	-1.7
Medication: Paracetamol	0.4	0.7	2.1	-0.1	0.3	-1.4
Headache pain in last month	0.8	1.3	2.1	-0.2	1.3	-1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.2	0.0	-1.5	0.4
Glaucoma (self-reported)	2.3	2.7	4.7	-1.7	-2.2	-0.9
Gout (self-reported)	1.2	1.7	4.6	0.4	2.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.3	-1.1	1.1	0.7
Medication: Amlodipine	0.3	0.4	0.5	0.6	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.3	0.7	1.5	-0.3
Birth weight	1.4	2.9	5.9	2.4	-1.4	1.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.3	-1.5	-0.7	-1.4
High blood pressure (siblings)	1.5	2.2	4.4	-2.1	1.2	-0.9
Forced vital capacity (FVC), Best measure	1.2	4.4	7.4	2.3	-0.8	2.7
Body fat percentage	1.0	4.0	10.8	-0.2	3.3	1.1
Leg fat percentage (right)	2.1	7.5	19.0	0.3	4.4	1.8
Arm fat-free mass (right)	0.3	1.3	3.0	0.9	-0.1	1.7
Exposure to tobacco smoke outside home	1.0	1.4	3.0	-1.7	1.1	-0.0
Comparative body size at age 10	1.1	2.9	7.3	-0.7	-1.0	-2.7
Number of full brothers	1.2	1.5	3.6	-0.9	1.9	-0.2
Worry too long after embarrassment	0.9	1.5	2.4	-1.6	1.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.9	-0.0	-0.1
Wheeze or whistling in the chest in last year	0.9	1.5	2.8	-1.7	-0.7	-1.2
Number of children fathered	1.3	1.5	3.1	-0.7	1.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	1.2	0.3	-0.6
Age at first live birth	1.4	2.6	5.7	-1.2	-2.4	-0.7
Pulse wave peak to peak time	4.2	4.9	12.1	-3.5	-0.8	-1.4
Health satisfaction	0.8	1.0	1.7	-0.2	1.3	1.2
Shortness of breath walking on level ground	2.3	2.7	4.4	-1.8	0.6	2.1
Qualifications: College or University degree	0.7	2.2	6.3	0.1	-2.5	0.4
Eye problems/disorders: None of the above	3.6	4.1	5.6	2.4	2.3	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-0.2	0.3	-1.1
Emphysema/chronic bronchitis	1.4	1.6	4.5	-2.1	-0.4	0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	3.1	1.5	-0.4	1.8
Neck or shoulder pain in last month	1.0	1.5	2.1	0.5	1.4	-1.4
Medication: Blood pressure	0.5	0.9	1.7	-0.9	1.3	-0.4
Angina (self-reported)	0.8	1.1	1.8	-0.3	1.1	-1.4
Migraine (self-reported)	0.8	1.0	2.9	-0.2	-1.7	0.4
Medication: Ibuprofen	0.9	1.0	1.9	-0.4	-1.4	-1.0
Medication: Allopurinol	1.0	1.4	3.3	-0.5	1.8	0.7
Medication: Omeprazole	1.3	1.5	3.1	-1.1	1.8	-0.5
Medication: Seretide 50 evohaler	3.1	3.6	6.1	-2.0	-0.7	-2.5
Mean time to correctly identify matches	1.0	1.9	5.3	-2.3	0.6	0.3
Heart disease (mother)	0.5	0.6	1.8	-1.4	-0.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.2	1.8	1.1	-1.5
Whole body fat mass	0.7	2.8	6.4	0.3	2.5	1.4
Leg fat mass (right)	1.1	4.3	9.1	0.4	3.0	1.9
Arm predicted mass (right)	0.2	1.1	2.7	0.8	-0.3	1.6
Pulse rate, automated reading	0.2	0.7	1.8	-1.4	0.1	-0.5
Alcohol intake frequency.	0.4	0.9	2.5	-0.0	0.3	-1.6
Comparative height size at age 10	0.5	2.7	6.6	1.2	-0.4	2.6
Number of full sisters	2.1	2.6	4.3	-2.1	-1.7	0.8
Suffer from ‘nerves’	0.2	0.4	0.7	-0.9	-0.1	-0.6
Overall health rating	0.7	1.5	4.4	-0.2	2.1	-0.2
Chest pain or discomfort	0.6	0.8	1.7	-0.7	1.3	0.6
Had major operations	0.1	0.1	0.2	-0.4	-0.3	0.1
Age at last live birth	1.9	2.8	5.3	-0.7	-2.3	-1.6
Family relationship satisfaction	0.7	0.8	1.6	1.2	-0.6	-0.8
Leg pain on walking	0.9	1.1	2.7	-1.6	0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.9	-1.0	-0.1	-1.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.7	0.3	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.2	-1.1	0.8	-0.6
Medication: Aspirin	0.4	0.6	1.6	-1.3	-0.3	-0.1
Supplements: Vitamin C	1.2	1.4	4.0	2.0	-0.3	0.3
Knee pain experienced in last month	0.9	1.4	2.9	-1.0	-0.6	-1.7
Hypertension (Self-reported)	1.1	3.0	7.5	-1.3	2.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.0	-2.2	0.4	0.7
Illnesses of father: Heart disease	1.3	1.8	2.6	-0.7	1.5	-1.6
Illnesses of siblings: Diabetes	1.6	1.9	4.1	2.0	0.4	1.3
Smoking status: Previous	1.6	2.4	3.3	-1.6	1.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.4	0.6	-0.7	0.4
Whole body fat-free mass	0.3	2.0	3.5	1.5	-0.3	1.9
Leg fat-free mass (right)	0.3	1.4	2.1	1.4	-0.4	1.4
Arm fat percentage (left)	0.6	2.2	6.2	0.2	2.5	0.5
Average weekly red wine intake	0.5	0.7	1.0	-1.0	-0.9	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.0	-0.7	0.8
Mood swings	0.2	0.4	1.1	-1.1	0.2	-0.1
Loneliness, isolation	0.5	0.7	2.0	-0.0	-0.5	-1.4
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.9	-0.0	0.9
Ever had bowel cancer screening	0.4	0.5	1.2	-0.4	-0.3	-1.1
Diabetes diagnosed by doctor	0.5	0.8	1.3	1.1	0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-1.0	1.3	-0.0
Friendships satisfaction	0.5	0.7	1.5	0.4	-1.2	-0.6
Qualifications: nursing, teaching	0.4	0.6	1.5	1.2	-0.4	0.2
Commuting to job workplace: Walk	0.9	1.0	2.9	0.2	0.4	1.7
Eye problems/disorders: Cataract	2.5	2.8	3.5	-1.8	-1.9	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.6	-1.9	0.5	-2.1
Medication for cholesterol	0.6	0.9	1.6	0.9	-1.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	3.5	-1.5	1.1	-1.9
Back pain experienced in last month	1.4	2.1	3.5	0.7	1.5	1.9
Mineral and other dietary supplements	2.5	3.4	5.5	1.0	1.9	2.3
Breast cancer (self-reported)	1.2	1.4	2.9	1.2	0.1	1.7
Asthma (self-reported)	1.0	2.0	4.0	2.0	1.3	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.2	-1.0	-0.8
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.1	-0.4	-0.7
Medication: Aspirin	0.3	0.3	0.8	-0.9	-0.3	-0.4
Medication: Gliclazide	3.3	3.7	7.2	-2.7	0.2	-1.9
Illnesses of father: None of the above (group 1)	2.1	2.5	7.2	2.7	-0.6	0.4
Smoking status: Current	0.3	0.5	1.1	0.3	-1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.5	2.3	1.0	0.6
Whole body water mass	0.3	1.7	2.9	1.5	-0.4	1.7
Leg predicted mass (right)	0.3	1.5	2.3	1.5	-0.5	1.4
Arm fat mass (left)	0.4	1.6	3.6	0.7	1.9	0.8
Number of self-reported non-cancer illnesses	0.6	1.0	1.6	-0.4	1.3	1.1
Average weekly champagne plus white wine intake	1.2	1.7	4.1	2.0	-0.1	0.9
Miserableness	1.1	2.0	4.1	-0.8	2.0	-1.1
Guilty feelings	0.4	0.6	1.3	-0.7	1.1	0.1
Wears glasses or contact lenses	0.5	0.5	0.8	0.9	0.6	0.7
Ever taken oral contraceptive pill	0.3	0.3	0.5	0.2	-0.7	-0.7
Hearing aid user	0.4	0.4	1.0	-0.5	1.0	-0.2
Mother’s age at death	1.0	1.2	3.6	0.3	-1.9	-0.1
Financial situation satisfaction	0.2	0.2	0.2	-0.4	-0.4	0.4
Tinnitus: Yes, now most or all of the time	2.2	2.5	4.7	-2.2	-1.7	-0.0
Commuting to job workplace: Public transport	0.7	0.8	2.1	0.6	-0.3	1.4
Eye problems/disorders: Glaucoma	1.7	2.0	3.3	-1.8	-1.7	-0.2
Medication: Blood pressure	1.0	2.0	3.8	-0.5	1.9	1.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.6	-1.6	1.0	0.2
Supplements: Fish oil (including cod liver oil)	1.1	1.4	1.7	-1.2	-1.3	-1.1
High cholesterol (Self-reported)	1.3	2.3	4.8	1.3	2.2	0.4
Medication: Bendroflumethiazide	0.8	1.2	2.6	-1.0	1.6	-0.3
Medication: Paracetamol	0.5	0.7	2.0	-0.3	-0.1	-1.4
Medication: Lisinopril	1.5	2.0	3.0	-0.5	1.6	1.7
Medication: Atorvastatin	0.5	0.6	1.1	0.4	0.7	-1.1
Illnesses of father: High blood pressure	1.1	1.4	3.4	-1.9	0.6	0.6
Alcohol drinker status: Never	0.7	0.9	1.4	-0.2	-1.1	1.2
Ever smoked	0.9	1.6	3.5	-0.4	1.2	1.9
Basal metabolic rate	0.3	1.9	3.6	1.4	0.2	1.9
Leg fat percentage (left)	2.0	7.1	18.4	0.4	4.3	1.6
Arm fat-free mass (left)	0.3	1.5	3.5	1.0	-0.1	1.9
Number of operations (self-reported)	1.5	2.2	6.0	0.3	-2.5	-0.6
Average weekly beer plus cider intake	0.6	0.9	2.3	-1.5	0.2	-0.6
Irritability	2.3	3.9	4.5	1.6	2.1	-2.1
Risk taking	1.5	2.2	5.7	-0.1	-2.4	0.9
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.3	1.8	0.6	0.2
Fractured/broken bones in last 5 years	1.4	1.8	3.1	-1.8	1.1	-1.1
Age started oral contraceptive pill	0.9	1.1	1.5	-1.1	-1.2	0.7
Diastolic blood pressure, automated reading	0.4	1.2	2.2	-1.5	0.4	1.1
Ever depressed for a whole week	1.0	1.2	2.4	-1.0	-1.5	-0.6
Unable to work because of sickness or disability	1.3	1.7	2.9	-1.1	-1.7	1.1
Commuting to job workplace: Cycle	1.6	1.9	4.4	1.1	-0.3	2.1
Myopia	1.3	1.9	3.4	-1.2	-1.8	-1.0
Vascular/heart problems diagnosed by doctor	1.3	3.6	9.9	1.0	-3.1	0.2
Cholesterol lowering medication	1.7	2.5	6.9	0.8	2.6	0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.6	-1.9	1.1	0.0
Pain experienced in last month	0.7	1.2	3.5	0.4	-1.9	0.1
Supplements: Calcium	2.9	3.2	6.2	-0.9	-2.5	1.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	1.1	0.5	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.3	0.2	1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.4	-0.6	-0.6	-1.6
Heart disease (siblings)	2.9	3.6	10.7	0.1	3.3	0.0
Alcohol drinker status: Previous	0.6	0.7	1.4	-0.9	-0.3	-1.2
Pack years of smoking	0.3	0.5	0.8	-0.9	0.4	0.6
Impedance of whole body	0.2	1.2	2.0	-1.4	1.1	0.8
Leg fat mass (left)	1.0	3.7	8.5	0.3	2.9	1.6
Arm predicted mass (left)	0.3	1.4	3.3	0.9	0.0	1.8