Hub : Genes

NOL9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0880	0.0400	7.0e-03	0.092	NA	0.072	NA	0.086	2.1e-07	NA	4.2e-06	NA	5.7e-07
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1380	0.0530	3.1e-03	0.139	NA	0.105	NA	0.109	5.0e-08	NA	2.2e-06	NA	1.5e-06
3	GTEx	Skin Sun Exposed Lower leg	0.1720	0.0470	3.8e-06	0.144	NA	0.116	NA	0.139	5.6e-12	NA	7.7e-10	NA	1.4e-11
4	YFS	Blood	0.0256	0.0095	2.0e-04	0.019	0.017	0.018	0.02	0.017	6.6e-07	1.7e-06	8.7e-07	3.4e-07	2.6e-06
5	TCGA	Brain Lower Grade Glioma	0.0847	0.0440	7.2e-03	-0.001	0.007	-0.002	NA	-0.001	5.0e-01	4.9e-02	6.4e-01	NA	4.5e-01
6	TCGA	Pheochromocytoma and Paraganglioma	0.0780	0.0410	1.5e-03	0.086	0.068	0.056	NA	0.062	2.7e-04	1.1e-03	3.0e-03	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	2.0	-0.0	-0.0	-0.1	1.4	0.0	0.9
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	0.4	-0.3	-0.6	1.6	-0.8	1.0
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	0.0	0.1	0.5	-0.6	0.4	-0.9
Depression (Nagel 2018)	0.4	0.6	2.3	-0.6	0.6	0.8	-0.3	-0.2	-1.5
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.1	-1.7	1.7	2.0	-2.7	1.3	-2.1
Neuroticism (Nagel 2018)	0.1	0.2	0.7	0.0	0.0	0.0	-0.7	0.1	-0.8
Schizophrenia (2018)	0.2	0.4	0.7	0.5	-0.4	-0.7	0.9	-0.8	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.6	0.6	-0.7	-0.6	0.4	-1.6	0.8
Worry (Nagel 2018)	0.7	1.4	3.0	-1.0	1.1	0.9	-1.4	0.6	-1.7
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.3	-0.4	0.0	-0.1	0.1	0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.3	0.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	-0.7	-0.3	0.3	-0.0	0.4
Crohns Disease (2017)	0.6	1.2	2.4	0.8	-0.9	-0.9	1.6	-1.5	0.8
Irritable Bowel Disease (IBD)	1.1	2.7	5.5	1.3	-1.4	-1.4	2.3	-1.9	1.3
Ulcerative Colitis (UC)	1.5	2.8	5.2	1.6	-1.6	-1.5	2.3	-1.2	1.6
Major Depression (MDD)	0.5	0.6	2.3	0.0	0.4	0.1	0.6	-1.5	-0.7
Reaction Time	2.3	4.3	8.2	1.8	-1.9	-2.4	2.9	-0.2	2.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.8	-0.8	0.6	1.1	-1.7	1.2	-0.9
Breast Cancer	0.0	0.1	0.4	0.2	0.1	0.2	0.1	0.6	-0.3
Ovarian Cancer	0.1	0.2	0.7	0.4	-0.5	-0.2	0.1	-0.2	0.8
Prostate Cancer	0.1	0.1	0.3	0.5	-0.5	-0.1	-0.2	0.3	0.2
Age at First Birth	0.7	1.0	2.0	-1.0	1.1	0.6	-1.4	0.6	-1.1
Bipolar Disorder (2011)	0.2	0.2	1.2	0.0	0.0	0.0	1.1	0.0	0.0
Body Mass Index (BMI) (2010)	2.8	3.8	4.5	-1.9	1.9	1.9	-2.0	2.1	-1.8
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.0	-0.2	0.4	0.2	0.1	0.4
Crohns Disease (2012)	0.2	0.3	1.0	0.5	-0.4	-0.3	1.0	-0.1	0.5
Mean Putamen Volume	0.5	0.6	1.9	0.3	-0.4	-0.6	1.4	-0.9	0.6
Fasting Glucose	0.3	0.4	2.1	-0.1	0.2	0.3	0.0	1.5	-0.3
HbA1C	3.1	3.5	5.4	-1.7	1.8	1.7	-2.3	2.0	-1.5
HDL Cholesterol	0.8	1.3	2.4	1.1	-1.0	-1.4	1.5	-0.3	1.0
LDL Cholesterol	4.4	7.0	10.0	-2.7	2.6	3.0	-2.9	1.0	-3.2
Lupus	2.3	3.4	6.4	-1.5	1.7	1.9	-2.5	0.5	-2.3
Neuroticism (2016)	0.2	0.3	0.7	-0.2	0.3	0.3	-0.8	0.8	-0.1
Primary Biliary Cirrhosis	0.6	0.8	1.4	-0.7	0.7	0.9	-1.2	0.9	-0.9
Rheumatoid Arthritis	0.3	0.4	0.7	0.4	-0.4	-0.9	0.6	0.3	0.8
Schizophrenia (2014)	0.0	0.1	0.5	-0.1	0.2	-0.1	0.7	-0.2	0.1
Triglycerides	1.1	1.8	2.4	-1.4	1.2	1.6	-1.4	1.2	-1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	0.0	0.8	0.4	0.2	1.1	-0.4
Ulcerative Colitis	0.4	0.5	1.6	0.2	-0.3	-0.3	1.3	-1.0	0.5
Blood Eosinophil Count	1.9	14.3	21.8	-4.0	3.9	4.0	-4.0	1.2	-4.7
Blood Platelet Count	1.6	18.0	22.8	-4.6	4.4	4.7	-4.3	2.0	-4.8
Blood Red Count	0.5	4.9	7.1	2.5	-2.3	-2.4	2.7	-0.8	2.0
Blood White Count	0.7	5.2	9.4	-2.1	2.4	2.7	-1.9	0.8	-3.1
Heel T-Score	2.3	18.3	33.6	-3.8	3.9	4.0	-4.4	5.8	-3.3
BMI	1.6	9.2	14.5	-2.7	2.7	2.9	-2.9	3.8	-3.1
Height	1.3	25.8	37.7	6.1	-6.1	-5.6	2.9	-4.1	4.9
Waist Hip Ratio (WHR)	0.3	1.6	2.7	1.6	-1.6	-1.5	0.2	-0.9	1.1
Systolic Blood Pressure	1.0	5.1	7.9	-2.0	2.2	2.0	-2.8	2.8	-1.5
Smoking Status	2.4	5.6	8.5	2.5	-2.6	-2.9	2.4	-1.4	2.2
Allergy or Eczema	1.3	3.5	4.9	-1.7	1.8	1.7	-1.6	-2.1	-2.2
Cardiovascular Disease	1.3	4.2	12.9	-1.1	1.2	1.2	-2.5	3.6	-1.4
Hypothyroidism (self reported)	0.1	0.3	0.6	0.6	-0.8	-0.4	0.4	-0.3	0.7
Respiratory disease	0.1	0.3	0.8	0.1	0.2	0.3	-0.4	-0.8	-0.9
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.7	-1.3	1.2	1.1	-1.4	1.9	-0.8
Lung FEV1/FVC ratio	3.6	18.1	46.0	-3.8	3.8	3.3	-3.4	6.8	-3.3
Lung FVC	0.5	2.5	5.1	1.9	-1.9	-1.5	0.8	-0.1	2.3
Neuroticism	0.2	0.4	0.8	0.9	-0.8	-0.7	0.4	-0.6	0.1
Chronotype (morning person)	0.5	1.1	2.4	1.0	-1.2	-0.8	0.7	-0.7	1.5
Hair Pigment	0.2	4.6	6.4	2.2	-2.2	-2.1	2.5	-1.9	1.8
Tanning	0.0	0.4	1.4	-0.5	0.6	0.2	0.3	1.2	0.0
Hand grip strength (left)	0.1	0.3	0.8	-0.2	0.3	0.3	-0.9	-0.6	-0.4
Number of treatments/medications taken	0.1	0.1	0.5	-0.1	0.1	-0.1	0.1	-0.7	0.1
Average weekly spirits intake	0.1	0.2	0.4	-0.6	0.5	0.4	-0.1	-0.4	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.3	0.5	-0.5	-0.1	-0.2	-0.0	0.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.3	-0.8	0.9	1.1	-0.4	0.1	-1.5
Hearing difficulty/problems: Yes	1.4	2.1	7.7	0.9	-0.7	-1.3	2.8	-0.1	1.4
Relative age of first facial hair	2.0	4.2	5.5	2.3	-2.2	-2.0	1.7	-2.4	1.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	0.6	-0.6	-1.1	1.1	0.6	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.2	-1.1	1.0	1.2	-0.8	-1.8	-1.1
Ever had hysterectomy (womb removed)	0.6	0.6	1.7	-0.7	0.6	0.9	-0.4	-1.3	-0.5
Systolic blood pressure, automated reading	0.3	0.9	1.7	-0.8	0.7	0.8	-1.2	1.3	-0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.2	-0.3	0.4	0.3	-0.2	-1.5	0.1
Angina	1.3	1.8	3.0	-1.7	1.6	1.4	-0.9	1.1	-0.9
Medication for hormone replacement therapy	0.7	0.8	1.3	-1.1	0.9	0.7	-0.2	-1.1	-1.1
Vitamin and mineral supplements	0.4	0.5	2.8	0.2	-0.2	-0.2	-0.4	1.7	0.4
Supplements: Zinc	0.7	0.8	3.0	0.2	-0.4	-0.4	1.7	-1.2	0.2
Medication: Co-codamol	0.3	0.4	1.2	0.1	-0.0	0.6	-1.1	-0.2	-0.8
Medication: Metformin	0.2	0.3	0.6	-0.5	0.4	0.4	-0.8	0.7	-0.3
Diabetes (father)	0.2	0.2	0.5	0.7	-0.6	-0.3	0.3	0.1	0.4
Diabetes (mother)	1.8	2.4	3.7	-1.3	1.3	1.4	-1.9	1.5	-1.6
Severe depression (siblings)	3.6	4.0	5.9	-2.4	2.1	2.4	-1.7	-0.1	-2.3
Pack years adult smoking proportion	0.4	0.5	1.1	0.9	-1.0	-0.5	-0.2	-0.2	0.9
Impedance of leg (right)	0.1	0.5	1.3	0.5	-0.5	-0.8	0.7	-0.3	1.1
Leg fat-free mass (left)	0.2	1.1	2.3	1.5	-1.5	-1.1	-0.1	0.2	0.7
Trunk fat percentage	0.3	1.0	4.7	-0.2	0.1	0.6	-0.9	2.2	-0.5
Hand grip strength (right)	0.2	0.4	1.6	-0.2	0.4	0.2	-0.7	-1.2	-0.4
Townsend deprivation index at recruitment	3.1	4.4	6.3	2.2	-2.5	-2.3	2.2	-0.0	2.2
Current tobacco smoking	0.7	1.1	1.6	1.3	-1.1	-1.2	0.8	0.8	1.1
Average weekly fortified wine intake	0.1	0.1	0.1	-0.2	0.3	0.1	-0.3	0.3	0.2
Maternal smoking around birth	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.5	-0.5	0.3
Fed-up feelings	0.8	1.5	3.7	1.9	-1.7	-1.1	0.7	0.0	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	-0.8	0.9	1.1	-0.6	1.0	-1.2
Relative age voice broke	1.6	2.5	3.6	1.6	-1.6	-1.9	1.6	-0.8	1.8
Taking other prescription medications	0.5	0.7	1.5	0.8	-0.9	-1.2	0.6	-0.0	0.9
Age when periods started (menarche)	1.0	2.4	3.6	1.9	-1.8	-1.4	1.0	-1.8	1.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.9	-1.7	1.4	1.3	-1.1	0.2	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.5	-1.2	1.4	1.7	-2.4	2.0	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.5	-0.6	-0.9	0.5	-0.1	1.0
Qualifications: CSEs or equivalent	2.6	3.4	4.7	-1.8	2.1	2.2	-1.5	1.1	-2.1
Serious illness, injury or assault to yourself	0.8	0.9	1.2	1.1	-1.1	-1.1	1.1	0.2	0.9
High blood pressure	0.8	2.2	5.1	-1.1	1.1	1.4	-2.3	1.5	-1.1
Hayfever, allergic rhinitis or eczema	1.0	2.2	2.5	-1.5	1.6	1.3	-1.6	-1.3	-1.6
Multivitamins +/- minerals	0.5	0.6	2.1	0.3	-0.2	-0.2	1.1	-1.4	0.2
Stomach or abdominal pain in last month	0.7	0.9	1.6	1.3	-1.1	-0.7	0.8	0.3	1.2
Supplements: Glucosamine	0.3	0.4	0.7	-0.9	0.8	0.7	0.1	0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.2	-1.1	1.0	0.9	-1.5	1.3	-1.0
Medication: Atenolol	2.1	2.6	4.6	-1.7	1.6	1.5	-2.2	0.6	-1.6
Medication: Levothyroxine sodium	0.3	0.5	0.7	0.8	-0.9	-0.7	0.8	-0.1	0.7
Sitting height	1.6	11.7	16.2	4.0	-4.0	-3.5	1.7	-3.4	3.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	-0.0	-0.1	0.1	-0.6	0.3
High blood pressure (mother)	0.9	1.3	5.6	0.0	0.0	-0.1	-1.5	2.4	-0.1
Body mass index (BMI)	0.7	3.1	9.2	-1.2	1.2	1.4	-1.6	3.0	-1.4
Impedance of leg (left)	0.1	0.5	1.1	0.6	-0.6	-0.7	0.8	-0.2	1.1
Leg predicted mass (left)	0.2	1.0	2.4	1.5	-1.5	-1.1	-0.1	0.2	0.7
Trunk fat mass	0.2	0.9	4.7	0.4	-0.4	0.1	-0.8	2.2	-0.1
Waist circumference	0.3	1.0	4.0	0.9	-0.8	-0.3	-0.7	2.0	0.0
Number of incorrect matches in round	0.3	0.6	1.1	-0.7	0.8	0.8	-0.6	-0.4	-1.1
Past tobacco smoking	2.6	4.7	6.5	-2.4	2.5	2.5	-2.2	1.1	-1.9
Alcohol usually taken with meals	0.1	0.1	0.2	-0.3	0.2	0.5	-0.4	0.3	0.2
Nervous feelings	1.2	2.3	4.3	-1.1	1.1	1.2	-2.1	1.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.1	0.0	0.2	-0.2	0.4	-0.2
Hearing difficulty/problems with background noise	2.9	4.6	9.6	1.9	-1.9	-2.1	3.1	-1.6	2.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	1.0	-0.8	-0.8	1.3	0.5	0.5
Had menopause	1.7	2.2	12.1	0.2	-0.3	-0.5	0.7	-3.5	0.2
Had other major operations	1.0	1.2	6.1	0.1	-0.2	-0.6	0.8	-2.5	0.3
Forced vital capacity (FVC)	1.6	6.0	8.5	2.9	-2.9	-2.8	1.2	-1.6	2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.4	-1.1	1.3	1.9	-1.6	1.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	-0.6	0.7	0.5	0.1	-1.4	-0.8
Qualifications: None of the above	0.3	0.6	3.1	-0.1	0.1	-0.3	0.4	1.8	0.0
Financial difficulties in last 2 years	0.8	1.1	5.2	0.2	-0.2	-0.7	0.7	2.3	0.6
Mouth/teeth dental problems	0.5	0.7	3.0	0.6	-0.4	-0.1	-0.8	-1.7	0.4
Heart attack	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.2	0.2
Allergy	0.8	1.9	2.6	1.2	-1.4	-1.3	1.6	1.2	1.6
Pain all over the body in last month	0.1	0.1	0.2	-0.2	0.2	0.5	-0.1	-0.5	-0.5
Diabetes (self-reported)	0.4	0.6	3.0	-0.2	0.1	-0.2	-0.5	1.7	0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	4.4	1.2	-1.3	-1.0	-0.0	-2.1	1.5
Medication: Ramipril	0.4	0.5	2.4	0.0	-0.0	-0.0	-0.7	1.5	0.2
Medication: Simvastatin	1.2	1.8	6.3	-0.8	1.0	0.9	-1.2	2.5	-0.8
Fluid intelligence score	0.6	1.2	1.7	-0.9	0.9	1.2	-1.3	1.2	-0.9
Illnesses of siblings	0.8	1.1	1.4	1.2	-1.0	-1.1	0.8	-1.2	0.9
Neuroticism score	0.1	0.1	0.4	0.6	-0.6	-0.3	0.0	0.0	0.0
Weight	0.2	1.0	2.4	1.1	-1.1	-0.7	-0.4	1.6	0.5
Impedance of arm (right)	0.0	0.2	0.5	0.1	-0.1	-0.4	0.6	-0.7	0.3
Arm fat percentage (right)	0.7	2.9	11.6	-1.0	0.9	1.1	-1.3	3.4	-1.2
Trunk fat-free mass	0.5	3.0	5.8	2.4	-2.3	-2.0	0.5	-0.7	1.5
Hip circumference	0.3	1.1	3.1	1.2	-1.2	-0.7	0.2	1.8	0.6
Time employed in main current job	1.0	1.1	1.7	-1.0	0.9	1.3	-0.9	1.0	-1.1
Alcohol intake versus 10 years previously	0.1	0.1	0.5	0.3	-0.3	-0.7	0.4	0.3	0.1
Father’s age at death	0.1	0.2	0.4	0.4	-0.4	-0.5	0.7	0.1	0.3
Worrier / anxious feelings	0.3	0.6	1.3	-0.6	0.7	0.7	-0.9	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.9	-0.9	-0.6	0.6	-0.5	0.6
Falls in the last year	0.8	1.0	3.7	0.9	-0.9	-0.5	0.1	-1.9	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.1	-0.2	-0.4	-0.4	0.4	0.5
Number of live births	1.1	1.5	2.1	-1.2	1.4	1.2	-0.9	1.5	-1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.3	1.5	-1.4	-1.5	0.2	0.5	1.5
Pulse rate	1.1	1.8	2.5	1.6	-1.6	-1.3	1.3	-0.9	1.3
Happiness	0.4	0.5	0.7	-0.8	0.8	0.7	-0.8	0.3	-0.5
Noisy workplace	0.7	0.9	3.3	0.5	-0.6	-0.7	1.8	-0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.2	0.2	-0.0	-0.5	0.2	-1.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.7	-0.7	-0.5	-0.3	-0.5	0.9
Mouth/teeth dental problems: Dentures	2.3	3.9	6.3	1.7	-2.0	-2.2	2.5	-0.3	2.2
Asthma	0.5	0.9	2.5	-0.5	0.7	1.0	-1.6	0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.1	0.8	-0.7	-0.9	1.8	0.4	1.3
Medication: Cholesterol lowering	2.0	3.0	4.8	-1.7	1.6	1.6	-2.2	1.7	-1.6
Depression (self-reported)	0.6	0.8	3.8	-0.6	0.3	-0.3	0.2	2.0	-0.5
Medication: Lansoprazole	0.8	0.9	1.5	0.9	-0.9	-0.9	0.7	-1.2	0.9
Prospective memory result	0.1	0.1	0.2	0.4	-0.3	-0.0	0.2	-0.2	0.1
Lung cancer (father)	0.3	0.4	1.0	-0.3	0.4	0.4	-0.4	1.0	-0.7
Illnesses of mother	0.1	0.1	0.4	-0.3	0.3	0.1	0.7	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.1	0.5	-0.6	-0.6	-0.6	1.0	0.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	0.4	-0.5	-0.5	-1.1	0.6	0.8
Impedance of arm (left)	0.1	0.5	1.2	0.6	-0.6	-0.4	0.8	-1.1	0.6
Arm fat mass (right)	0.3	1.3	7.1	0.0	-0.0	0.3	-0.9	2.7	-0.4
Trunk predicted mass	0.6	3.4	6.4	2.5	-2.4	-2.1	0.6	-0.8	1.7
Standing height	1.5	15.2	22.8	4.8	-4.6	-4.2	2.4	-2.9	3.8
Length of working week for main job	1.2	1.4	2.0	-1.4	1.2	1.3	-1.2	0.8	-1.0
Exposure to tobacco smoke at home	0.5	0.5	1.0	0.9	-1.0	-0.6	0.3	0.2	0.8
Breastfed as a baby	0.0	0.1	0.1	-0.4	0.2	0.0	0.3	-0.3	-0.2
Tense / ‘highly strung’	0.4	0.7	2.0	-0.6	0.7	0.5	-1.1	0.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.2	-0.3	-0.4	0.3	0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.2	0.1	0.0	-0.1	-0.8	0.7
Birth weight of first child	0.9	1.7	3.3	1.1	-1.3	-1.5	1.2	-1.8	0.8
Peak expiratory flow (PEF)	1.1	2.6	4.9	-1.2	1.2	1.1	-2.2	1.9	-1.6
Pulse wave reflection index	0.8	1.0	2.7	-0.9	0.7	0.6	-1.6	1.2	-0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.6	0.6	-0.6	-0.8	1.3	-1.6	0.7
Loud music exposure frequency	0.9	1.0	2.2	1.1	-1.0	-1.2	1.5	0.1	0.6
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.3	0.1	0.2
Mouth/teeth dental problems: Bleeding gums	2.6	3.3	9.3	-1.5	1.6	1.5	-1.2	3.0	-1.5
Blood clot in the leg (DVT)	0.9	1.2	2.0	-1.0	1.2	1.4	-0.9	-0.2	-1.3
Medication: Paracetamol	0.3	0.6	1.7	0.6	-0.5	-0.8	1.3	0.1	0.7
Headache pain in last month	0.1	0.2	0.5	0.0	0.0	-0.1	0.7	0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	2.3	3.7	6.2	2.0	-1.8	-1.8	2.5	-1.9	1.4
Glaucoma (self-reported)	2.9	3.4	6.4	1.7	-1.7	-1.6	1.9	-2.5	1.4
Gout (self-reported)	0.9	1.2	1.8	-1.1	1.1	1.2	-1.3	0.6	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.2	0.9	-1.0	-0.6	0.8	-1.1	0.7
Medication: Amlodipine	2.0	2.8	4.1	-1.7	1.8	1.8	-1.7	0.7	-2.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.2	-0.0	0.3	-0.4	-0.6	-0.8
Birth weight	2.5	5.4	7.3	2.6	-2.7	-2.3	2.2	-2.1	1.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	-0.1	-0.0	0.4	0.6	-1.3	0.2
High blood pressure (siblings)	0.7	1.1	1.5	-1.1	1.1	1.2	-1.2	-0.2	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.7	2.5	1.5	-1.6	-1.5	0.3	-0.9	1.4
Body fat percentage	0.4	1.7	8.4	-0.4	0.3	0.7	-1.1	2.9	-0.6
Leg fat percentage (right)	0.9	3.4	14.2	-1.0	1.0	1.1	-1.6	3.8	-0.9
Arm fat-free mass (right)	0.5	2.4	5.2	2.3	-2.2	-1.6	0.3	-0.3	1.4
Exposure to tobacco smoke outside home	0.7	1.0	1.7	1.3	-1.1	-1.0	0.9	-0.2	1.0
Comparative body size at age 10	5.2	14.4	23.5	-3.8	3.5	3.7	-3.5	4.8	-3.2
Number of full brothers	0.1	0.1	0.4	0.1	-0.2	0.1	-0.2	-0.7	0.2
Worry too long after embarrassment	0.4	0.7	1.3	0.8	-0.9	-1.1	0.8	-0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.5	1.5	-1.5	-1.4	1.6	0.1	1.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	-0.6	-0.2	-0.4	-0.3	0.0
Number of children fathered	0.2	0.3	0.7	0.1	-0.2	-0.8	0.6	0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	4.0	0.3	-0.4	-0.6	0.6	-2.0	0.4
Age at first live birth	0.1	0.2	0.6	-0.4	0.3	0.2	0.1	0.2	-0.7
Pulse wave peak to peak time	0.3	0.4	1.2	-0.2	0.3	0.3	1.1	-0.6	-0.6
Health satisfaction	1.8	2.4	3.0	1.6	-1.6	-1.6	1.7	-0.9	1.7
Shortness of breath walking on level ground	4.8	5.7	7.7	2.7	-2.8	-2.5	2.4	-0.5	2.7
Qualifications: College or University degree	0.5	1.5	9.1	-0.0	0.0	-0.1	0.3	-3.0	-0.0
Eye problems/disorders: None of the above	2.3	2.7	8.0	-1.4	1.0	0.6	-1.8	2.8	-1.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.6	0.6	0.3	0.3	0.1	-0.2
Emphysema/chronic bronchitis	0.3	0.4	0.7	0.8	-0.8	-0.5	0.4	-0.5	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	-0.6	0.5	0.6	-0.6	-0.4	-0.6
Neck or shoulder pain in last month	0.6	0.8	3.8	0.4	-0.4	-0.5	0.7	1.9	0.1
Medication: Blood pressure	3.0	5.3	10.4	-2.3	2.2	2.4	-3.2	1.5	-1.8
Angina (self-reported)	2.3	3.1	5.2	-2.3	2.1	1.9	-1.3	1.2	-1.4
Migraine (self-reported)	1.2	1.4	2.3	1.0	-1.0	-1.1	1.4	-1.5	1.1
Medication: Ibuprofen	1.5	1.9	3.9	1.3	-1.2	-1.2	2.0	-0.1	1.6
Medication: Allopurinol	0.1	0.1	0.2	-0.1	0.1	0.3	-0.4	-0.5	0.0
Medication: Omeprazole	0.7	0.8	1.8	-0.4	0.5	0.7	-1.3	1.4	-0.6
Medication: Seretide 50 evohaler	1.1	1.2	1.8	-0.8	1.2	1.2	-1.3	0.9	-1.2
Mean time to correctly identify matches	1.3	2.5	5.4	1.2	-1.4	-1.7	2.3	0.3	1.8
Heart disease (mother)	0.2	0.3	0.7	-0.3	0.1	-0.3	0.8	-0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.9	4.6	5.2	-2.2	2.3	2.3	-2.3	1.9	-2.0
Whole body fat mass	0.3	1.3	7.0	0.4	-0.4	0.1	-0.8	2.7	-0.0
Leg fat mass (right)	0.4	1.6	8.6	0.1	-0.1	0.2	-0.9	2.9	-0.2
Arm predicted mass (right)	0.5	2.5	5.3	2.3	-2.2	-1.6	0.4	-0.3	1.5
Pulse rate, automated reading	0.2	0.7	1.6	1.2	-1.3	-0.7	0.1	-0.2	0.5
Alcohol intake frequency.	0.6	1.4	2.6	-1.0	1.0	1.1	-1.2	1.6	-1.0
Comparative height size at age 10	1.8	10.0	14.7	3.8	-3.8	-3.5	2.3	-0.9	3.5
Number of full sisters	1.6	1.9	2.8	1.7	-1.6	-1.3	1.7	-0.6	1.3
Suffer from ‘nerves’	0.2	0.3	0.8	-0.6	0.4	0.3	-0.7	0.9	-0.2
Overall health rating	0.2	0.5	1.8	-0.3	0.4	0.6	-0.4	1.3	-0.7
Chest pain or discomfort	0.2	0.3	1.7	0.4	-0.3	0.2	-0.1	1.3	0.2
Had major operations	0.0	0.0	0.2	-0.1	0.1	0.1	0.2	-0.0	0.4
Age at last live birth	2.0	2.9	5.8	-1.7	1.7	1.8	-1.5	0.7	-2.4
Family relationship satisfaction	0.1	0.1	0.3	-0.3	0.4	0.4	-0.6	0.2	-0.3
Leg pain on walking	1.5	1.9	3.0	1.7	-1.6	-1.1	1.1	-1.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.5	-0.6	-0.2	0.2	-0.5	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	0.6	0.6	-0.6	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	-1.2	1.3	1.6	-0.8	-0.4	-1.3
Medication: Aspirin	0.5	0.6	0.8	0.8	-0.9	-0.8	0.6	-0.6	0.9
Supplements: Vitamin C	0.1	0.1	0.5	-0.0	0.0	-0.1	0.3	-0.7	-0.2
Knee pain experienced in last month	0.3	0.4	0.8	-0.7	0.8	0.9	-0.1	0.3	-0.8
Hypertension (Self-reported)	1.0	2.7	5.3	-1.3	1.3	1.5	-2.3	1.8	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	2.0	1.3	-1.4	-1.1	1.2	-0.6	1.3
Illnesses of father: Heart disease	2.3	3.1	3.6	-1.9	1.8	1.9	-1.8	1.6	-1.6
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.3	-0.5	-1.0	0.6	0.4	0.6
Smoking status: Previous	2.5	3.7	4.5	1.8	-2.0	-2.1	1.9	-2.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	1.0	-1.0	-0.7	-0.2	-0.5	0.3
Whole body fat-free mass	0.3	1.9	4.0	2.0	-1.9	-1.5	0.2	-0.2	1.1
Leg fat-free mass (right)	0.2	1.2	2.9	1.7	-1.6	-1.1	0.1	0.0	0.7
Arm fat percentage (left)	0.6	2.5	10.7	-0.7	0.7	1.0	-1.2	3.3	-1.0
Average weekly red wine intake	0.8	1.2	4.2	0.8	-0.8	-0.6	1.2	-2.0	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.7	0.0	0.0	-0.2	-0.2	-0.9	0.5
Mood swings	0.3	0.6	1.6	1.3	-1.1	-0.6	0.2	-0.5	0.2
Loneliness, isolation	1.4	1.9	3.1	-1.1	1.2	1.3	-1.4	1.8	-1.5
Long-standing illness, disability or infirmity	0.5	0.7	1.1	0.9	-0.9	-1.1	0.8	0.7	0.7
Ever had bowel cancer screening	1.5	1.7	2.3	-1.2	1.2	1.5	-1.5	1.1	-1.2
Diabetes diagnosed by doctor	0.3	0.5	2.4	-0.3	0.2	0.1	-0.7	1.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.5	0.6	0.5	-0.5	-0.9	-1.1
Friendships satisfaction	0.1	0.1	0.3	-0.5	0.5	0.3	-0.1	0.3	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	0.5	0.1	-0.4	-0.6	-0.3
Commuting to job workplace: Walk	4.7	5.1	7.1	2.5	-2.4	-2.5	2.3	-0.1	2.7
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.3	0.6	0.9	-0.5	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.8	-1.6	1.7	1.8	-1.1	0.7	-2.0
Medication for cholesterol	0.0	0.0	0.1	0.0	-0.1	-0.3	0.3	-0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.1	-1.0	1.2	1.4	-0.8	0.8	-1.0
Back pain experienced in last month	3.1	4.5	6.2	2.4	-2.5	-2.3	2.1	-0.6	2.2
Mineral and other dietary supplements	0.4	0.5	1.8	0.4	-0.4	-0.3	-0.6	1.4	0.7
Breast cancer (self-reported)	0.5	0.6	1.3	0.1	-0.4	-1.1	0.1	-1.1	0.8
Asthma (self-reported)	0.4	0.8	2.2	-0.4	0.6	0.9	-1.5	0.1	-1.1
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.4	0.5	0.7	-0.9	0.3	-0.6
Osteoarthritis (self-reported)	0.3	0.3	1.0	0.4	-0.5	-0.3	0.7	-1.0	0.3
Medication: Aspirin	0.0	0.1	0.1	0.3	-0.3	-0.2	0.1	-0.3	0.2
Medication: Gliclazide	2.7	3.0	4.2	-1.6	1.7	1.9	-2.1	1.1	-1.9
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.1	0.2	0.3	-0.6	0.6	-0.5
Smoking status: Current	0.9	1.4	2.2	1.5	-1.3	-1.3	0.9	0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.0	-1.2	1.1	1.0	-1.0	1.4	-1.1
Whole body water mass	0.3	1.7	3.7	1.9	-1.8	-1.4	0.1	-0.2	1.1
Leg predicted mass (right)	0.2	1.2	2.9	1.7	-1.6	-1.1	0.0	0.1	0.7
Arm fat mass (left)	0.4	1.5	7.4	-0.2	0.1	0.5	-1.0	2.7	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.1	0.1	0.2	-0.9	0.5	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.5	-0.4	-0.7	0.5	0.2	0.7
Miserableness	0.0	0.0	0.2	0.1	-0.1	-0.0	0.1	-0.4	-0.2
Guilty feelings	1.8	2.8	3.5	1.8	-1.9	-1.7	1.8	-1.5	1.4
Wears glasses or contact lenses	1.5	1.7	3.2	1.0	-1.1	-1.1	1.5	-1.8	1.1
Ever taken oral contraceptive pill	1.1	1.2	1.7	-1.3	1.3	1.1	-0.8	0.8	-1.1
Hearing aid user	0.2	0.2	0.8	-0.4	0.5	0.0	-0.1	0.9	0.1
Mother’s age at death	0.1	0.1	0.1	0.2	-0.2	-0.1	0.1	0.4	0.4
Financial situation satisfaction	1.2	1.4	2.4	1.3	-1.4	-1.6	1.2	-0.1	1.0
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.7	1.0	-1.0	-1.4	2.2	-0.1	1.7
Commuting to job workplace: Public transport	1.0	1.2	1.5	0.9	-1.0	-1.1	1.2	1.2	1.2
Eye problems/disorders: Glaucoma	3.8	4.5	7.6	2.0	-1.9	-1.9	2.3	-2.8	1.7
Medication: Blood pressure	0.3	0.6	1.3	0.8	-0.8	-0.5	-0.2	1.1	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.6	-0.6	-0.5	0.2	0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.6	0.6	-0.6	-0.8	1.0	-1.9	0.4
High cholesterol (Self-reported)	0.7	1.2	6.2	-0.2	0.4	0.4	-0.7	2.5	-0.2
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.5	0.4	1.0	-1.4	0.1	-0.6
Medication: Paracetamol	0.1	0.1	0.5	-0.1	0.2	-0.3	0.7	0.0	0.2
Medication: Lisinopril	0.7	0.9	1.5	1.1	-1.2	-0.8	-0.3	0.4	1.2
Medication: Atorvastatin	1.6	1.9	3.7	-1.1	1.1	1.6	-1.9	-0.6	-1.6
Illnesses of father: High blood pressure	0.3	0.4	1.8	0.2	-0.3	-0.1	0.4	1.3	0.3
Alcohol drinker status: Never	1.7	2.0	2.8	1.7	-1.7	-1.4	1.5	0.2	1.6
Ever smoked	0.7	1.3	2.2	1.4	-1.5	-1.4	0.9	0.3	1.0
Basal metabolic rate	0.3	1.7	3.6	1.9	-1.8	-1.4	0.1	0.2	1.1
Leg fat percentage (left)	0.9	3.4	14.1	-0.9	0.9	1.1	-1.5	3.8	-0.9
Arm fat-free mass (left)	0.3	1.7	3.5	1.9	-1.8	-1.4	0.1	0.2	1.2
Number of operations (self-reported)	0.2	0.2	0.9	-0.5	0.3	-0.0	0.4	-0.9	-0.2
Average weekly beer plus cider intake	0.2	0.4	1.1	0.3	-0.2	-0.2	0.9	-1.0	-0.2
Irritability	1.8	3.1	5.1	-1.7	1.8	1.7	-2.1	-0.4	-2.2
Risk taking	1.3	2.0	4.0	1.3	-1.5	-1.5	2.0	-0.8	0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	-0.2	0.1	0.2	-0.7	0.9	-0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.2	-0.3	0.0	0.1	0.1	-0.1
Age started oral contraceptive pill	0.1	0.2	0.4	-0.5	0.5	0.6	0.1	-0.1	-0.3
Diastolic blood pressure, automated reading	0.9	2.8	3.8	1.7	-1.7	-1.6	1.9	0.9	1.9
Ever depressed for a whole week	0.2	0.2	1.3	-0.1	0.3	0.1	-0.1	-1.1	-0.2
Unable to work because of sickness or disability	1.3	1.7	2.4	1.5	-1.5	-1.6	1.1	0.4	1.4
Commuting to job workplace: Cycle	2.7	3.3	5.5	1.8	-1.6	-1.9	2.1	-0.4	2.3
Myopia	0.3	0.5	2.0	-0.1	-0.1	-0.4	1.4	-0.7	0.4
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.2	1.3	-1.3	-1.6	2.3	-1.6	1.4
Cholesterol lowering medication	0.7	1.0	4.4	-0.5	0.7	0.7	-0.6	2.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	1.2	-1.1	-1.0	0.3	0.3	1.1
Pain experienced in last month	1.6	2.7	3.2	-1.7	1.8	1.6	-1.7	-1.8	-1.1
Supplements: Calcium	1.6	1.8	2.7	1.2	-1.3	-1.4	1.5	-0.6	1.6
Basal cell carcinoma (self-reported)	2.1	2.5	4.1	-1.9	1.8	1.4	-1.5	-0.0	-2.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.6	0.3	0.1	-0.3	-0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.9	-1.0	1.2	1.4	-0.9	-0.1	-1.4
Heart disease (siblings)	1.1	1.4	4.2	-0.9	0.8	1.1	-0.8	2.0	-1.0
Alcohol drinker status: Previous	1.5	1.7	2.2	-1.3	1.3	1.5	-1.1	1.0	-1.5
Pack years of smoking	0.5	0.8	1.5	1.1	-1.2	-0.8	0.2	-0.3	1.1
Impedance of whole body	0.1	0.7	1.0	0.7	-0.7	-0.7	0.9	-0.9	1.0
Leg fat mass (left)	0.4	1.7	9.1	0.1	-0.1	0.3	-1.0	3.0	-0.3
Arm predicted mass (left)	0.3	1.6	3.5	1.9	-1.8	-1.4	0.1	0.2	1.1