Hub : Genes

NOL9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0880 0.0400 7.0e-03 0.092 NA 0.072 NA 0.086 2.1e-07 NA 4.2e-06 NA 5.7e-07
2 GTEx Skin Not Sun Exposed Suprapubic 0.1380 0.0530 3.1e-03 0.139 NA 0.105 NA 0.109 5.0e-08 NA 2.2e-06 NA 1.5e-06
3 GTEx Skin Sun Exposed Lower leg 0.1720 0.0470 3.8e-06 0.144 NA 0.116 NA 0.139 5.6e-12 NA 7.7e-10 NA 1.4e-11
4 YFS Blood 0.0256 0.0095 2.0e-04 0.019 0.017 0.018 0.02 0.017 6.6e-07 1.7e-06 8.7e-07 3.4e-07 2.6e-06
5 TCGA Brain Lower Grade Glioma 0.0847 0.0440 7.2e-03 -0.001 0.007 -0.002 NA -0.001 5.0e-01 4.9e-02 6.4e-01 NA 4.5e-01
6 TCGA Pheochromocytoma and Paraganglioma 0.0780 0.0410 1.5e-03 0.086 0.068 0.056 NA 0.062 2.7e-04 1.1e-03 3.0e-03 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 2.0 -0.0 -0.0 -0.1 1.4 0.0 0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 2.4 0.4 -0.3 -0.6 1.6 -0.8 1.0
Depressed Affect (Nagel 2018) 0.1 0.3 0.8 0.0 0.1 0.5 -0.6 0.4 -0.9
Depression (Nagel 2018) 0.4 0.6 2.3 -0.6 0.6 0.8 -0.3 -0.2 -1.5
Intelligence (Savage-Jansen 2018) 1.3 3.9 7.1 -1.7 1.7 2.0 -2.7 1.3 -2.1
Neuroticism (Nagel 2018) 0.1 0.2 0.7 0.0 0.0 0.0 -0.7 0.1 -0.8
Schizophrenia (2018) 0.2 0.4 0.7 0.5 -0.4 -0.7 0.9 -0.8 0.6
Schizophrenia vs Biploar Disorder 0.6 0.8 2.6 0.6 -0.7 -0.6 0.4 -1.6 0.8
Worry (Nagel 2018) 0.7 1.4 3.0 -1.0 1.1 0.9 -1.4 0.6 -1.7
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 0.3 -0.4 0.0 -0.1 0.1 0.2
Alzheimer’s Disease (in father) 0.0 0.0 0.1 -0.1 0.1 -0.1 0.1 -0.3 0.0
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.6 -0.7 -0.3 0.3 -0.0 0.4
Crohns Disease (2017) 0.6 1.2 2.4 0.8 -0.9 -0.9 1.6 -1.5 0.8
Irritable Bowel Disease (IBD) 1.1 2.7 5.5 1.3 -1.4 -1.4 2.3 -1.9 1.3
Ulcerative Colitis (UC) 1.5 2.8 5.2 1.6 -1.6 -1.5 2.3 -1.2 1.6
Major Depression (MDD) 0.5 0.6 2.3 0.0 0.4 0.1 0.6 -1.5 -0.7
Reaction Time 2.3 4.3 8.2 1.8 -1.9 -2.4 2.9 -0.2 2.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.8 -0.8 0.6 1.1 -1.7 1.2 -0.9
Breast Cancer 0.0 0.1 0.4 0.2 0.1 0.2 0.1 0.6 -0.3
Ovarian Cancer 0.1 0.2 0.7 0.4 -0.5 -0.2 0.1 -0.2 0.8
Prostate Cancer 0.1 0.1 0.3 0.5 -0.5 -0.1 -0.2 0.3 0.2
Age at First Birth 0.7 1.0 2.0 -1.0 1.1 0.6 -1.4 0.6 -1.1
Bipolar Disorder (2011) 0.2 0.2 1.2 0.0 0.0 0.0 1.1 0.0 0.0
Body Mass Index (BMI) (2010) 2.8 3.8 4.5 -1.9 1.9 1.9 -2.0 2.1 -1.8
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.0 -0.2 0.4 0.2 0.1 0.4
Crohns Disease (2012) 0.2 0.3 1.0 0.5 -0.4 -0.3 1.0 -0.1 0.5
Mean Putamen Volume 0.5 0.6 1.9 0.3 -0.4 -0.6 1.4 -0.9 0.6
Fasting Glucose 0.3 0.4 2.1 -0.1 0.2 0.3 0.0 1.5 -0.3
HbA1C 3.1 3.5 5.4 -1.7 1.8 1.7 -2.3 2.0 -1.5
HDL Cholesterol 0.8 1.3 2.4 1.1 -1.0 -1.4 1.5 -0.3 1.0
LDL Cholesterol 4.4 7.0 10.0 -2.7 2.6 3.0 -2.9 1.0 -3.2
Lupus 2.3 3.4 6.4 -1.5 1.7 1.9 -2.5 0.5 -2.3
Neuroticism (2016) 0.2 0.3 0.7 -0.2 0.3 0.3 -0.8 0.8 -0.1
Primary Biliary Cirrhosis 0.6 0.8 1.4 -0.7 0.7 0.9 -1.2 0.9 -0.9
Rheumatoid Arthritis 0.3 0.4 0.7 0.4 -0.4 -0.9 0.6 0.3 0.8
Schizophrenia (2014) 0.0 0.1 0.5 -0.1 0.2 -0.1 0.7 -0.2 0.1
Triglycerides 1.1 1.8 2.4 -1.4 1.2 1.6 -1.4 1.2 -1.3
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 0.0 0.8 0.4 0.2 1.1 -0.4
Ulcerative Colitis 0.4 0.5 1.6 0.2 -0.3 -0.3 1.3 -1.0 0.5
Blood Eosinophil Count 1.9 14.3 21.8 -4.0 3.9 4.0 -4.0 1.2 -4.7
Blood Platelet Count 1.6 18.0 22.8 -4.6 4.4 4.7 -4.3 2.0 -4.8
Blood Red Count 0.5 4.9 7.1 2.5 -2.3 -2.4 2.7 -0.8 2.0
Blood White Count 0.7 5.2 9.4 -2.1 2.4 2.7 -1.9 0.8 -3.1
Heel T-Score 2.3 18.3 33.6 -3.8 3.9 4.0 -4.4 5.8 -3.3
BMI 1.6 9.2 14.5 -2.7 2.7 2.9 -2.9 3.8 -3.1
Height 1.3 25.8 37.7 6.1 -6.1 -5.6 2.9 -4.1 4.9
Waist Hip Ratio (WHR) 0.3 1.6 2.7 1.6 -1.6 -1.5 0.2 -0.9 1.1
Systolic Blood Pressure 1.0 5.1 7.9 -2.0 2.2 2.0 -2.8 2.8 -1.5
Smoking Status 2.4 5.6 8.5 2.5 -2.6 -2.9 2.4 -1.4 2.2
Allergy or Eczema 1.3 3.5 4.9 -1.7 1.8 1.7 -1.6 -2.1 -2.2
Cardiovascular Disease 1.3 4.2 12.9 -1.1 1.2 1.2 -2.5 3.6 -1.4
Hypothyroidism (self reported) 0.1 0.3 0.6 0.6 -0.8 -0.4 0.4 -0.3 0.7
Respiratory disease 0.1 0.3 0.8 0.1 0.2 0.3 -0.4 -0.8 -0.9
Type 2 Diabetes (T2D) (2018) 0.9 1.8 3.7 -1.3 1.2 1.1 -1.4 1.9 -0.8
Lung FEV1/FVC ratio 3.6 18.1 46.0 -3.8 3.8 3.3 -3.4 6.8 -3.3
Lung FVC 0.5 2.5 5.1 1.9 -1.9 -1.5 0.8 -0.1 2.3
Neuroticism 0.2 0.4 0.8 0.9 -0.8 -0.7 0.4 -0.6 0.1
Chronotype (morning person) 0.5 1.1 2.4 1.0 -1.2 -0.8 0.7 -0.7 1.5
Hair Pigment 0.2 4.6 6.4 2.2 -2.2 -2.1 2.5 -1.9 1.8
Tanning 0.0 0.4 1.4 -0.5 0.6 0.2 0.3 1.2 0.0
Hand grip strength (left) 0.1 0.3 0.8 -0.2 0.3 0.3 -0.9 -0.6 -0.4
Number of treatments/medications taken 0.1 0.1 0.5 -0.1 0.1 -0.1 0.1 -0.7 0.1
Average weekly spirits intake 0.1 0.2 0.4 -0.6 0.5 0.4 -0.1 -0.4 -0.2
Sensitivity / hurt feelings 0.1 0.1 0.3 0.5 -0.5 -0.1 -0.2 -0.0 0.0
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.3 -0.8 0.9 1.1 -0.4 0.1 -1.5
Hearing difficulty/problems: Yes 1.4 2.1 7.7 0.9 -0.7 -1.3 2.8 -0.1 1.4
Relative age of first facial hair 2.0 4.2 5.5 2.3 -2.2 -2.0 1.7 -2.4 1.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.2 0.6 -0.6 -1.1 1.1 0.6 0.5
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.2 -1.1 1.0 1.2 -0.8 -1.8 -1.1
Ever had hysterectomy (womb removed) 0.6 0.6 1.7 -0.7 0.6 0.9 -0.4 -1.3 -0.5
Systolic blood pressure, automated reading 0.3 0.9 1.7 -0.8 0.7 0.8 -1.2 1.3 -0.5
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 2.2 -0.3 0.4 0.3 -0.2 -1.5 0.1
Angina 1.3 1.8 3.0 -1.7 1.6 1.4 -0.9 1.1 -0.9
Medication for hormone replacement therapy 0.7 0.8 1.3 -1.1 0.9 0.7 -0.2 -1.1 -1.1
Vitamin and mineral supplements 0.4 0.5 2.8 0.2 -0.2 -0.2 -0.4 1.7 0.4
Supplements: Zinc 0.7 0.8 3.0 0.2 -0.4 -0.4 1.7 -1.2 0.2
Medication: Co-codamol 0.3 0.4 1.2 0.1 -0.0 0.6 -1.1 -0.2 -0.8
Medication: Metformin 0.2 0.3 0.6 -0.5 0.4 0.4 -0.8 0.7 -0.3
Diabetes (father) 0.2 0.2 0.5 0.7 -0.6 -0.3 0.3 0.1 0.4
Diabetes (mother) 1.8 2.4 3.7 -1.3 1.3 1.4 -1.9 1.5 -1.6
Severe depression (siblings) 3.6 4.0 5.9 -2.4 2.1 2.4 -1.7 -0.1 -2.3
Pack years adult smoking proportion 0.4 0.5 1.1 0.9 -1.0 -0.5 -0.2 -0.2 0.9
Impedance of leg (right) 0.1 0.5 1.3 0.5 -0.5 -0.8 0.7 -0.3 1.1
Leg fat-free mass (left) 0.2 1.1 2.3 1.5 -1.5 -1.1 -0.1 0.2 0.7
Trunk fat percentage 0.3 1.0 4.7 -0.2 0.1 0.6 -0.9 2.2 -0.5
Hand grip strength (right) 0.2 0.4 1.6 -0.2 0.4 0.2 -0.7 -1.2 -0.4
Townsend deprivation index at recruitment 3.1 4.4 6.3 2.2 -2.5 -2.3 2.2 -0.0 2.2
Current tobacco smoking 0.7 1.1 1.6 1.3 -1.1 -1.2 0.8 0.8 1.1
Average weekly fortified wine intake 0.1 0.1 0.1 -0.2 0.3 0.1 -0.3 0.3 0.2
Maternal smoking around birth 0.1 0.1 0.3 0.3 -0.2 -0.2 -0.5 -0.5 0.3
Fed-up feelings 0.8 1.5 3.7 1.9 -1.7 -1.1 0.7 0.0 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.3 -0.8 0.9 1.1 -0.6 1.0 -1.2
Relative age voice broke 1.6 2.5 3.6 1.6 -1.6 -1.9 1.6 -0.8 1.8
Taking other prescription medications 0.5 0.7 1.5 0.8 -0.9 -1.2 0.6 -0.0 0.9
Age when periods started (menarche) 1.0 2.4 3.6 1.9 -1.8 -1.4 1.0 -1.8 1.2
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 2.9 -1.7 1.4 1.3 -1.1 0.2 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 5.5 -1.2 1.4 1.7 -2.4 2.0 -1.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.0 0.5 -0.6 -0.9 0.5 -0.1 1.0
Qualifications: CSEs or equivalent 2.6 3.4 4.7 -1.8 2.1 2.2 -1.5 1.1 -2.1
Serious illness, injury or assault to yourself 0.8 0.9 1.2 1.1 -1.1 -1.1 1.1 0.2 0.9
High blood pressure 0.8 2.2 5.1 -1.1 1.1 1.4 -2.3 1.5 -1.1
Hayfever, allergic rhinitis or eczema 1.0 2.2 2.5 -1.5 1.6 1.3 -1.6 -1.3 -1.6
Multivitamins +/- minerals 0.5 0.6 2.1 0.3 -0.2 -0.2 1.1 -1.4 0.2
Stomach or abdominal pain in last month 0.7 0.9 1.6 1.3 -1.1 -0.7 0.8 0.3 1.2
Supplements: Glucosamine 0.3 0.4 0.7 -0.9 0.8 0.7 0.1 0.5 -0.6
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.2 -1.1 1.0 0.9 -1.5 1.3 -1.0
Medication: Atenolol 2.1 2.6 4.6 -1.7 1.6 1.5 -2.2 0.6 -1.6
Medication: Levothyroxine sodium 0.3 0.5 0.7 0.8 -0.9 -0.7 0.8 -0.1 0.7
Sitting height 1.6 11.7 16.2 4.0 -4.0 -3.5 1.7 -3.4 3.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.1 -0.0 -0.1 0.1 -0.6 0.3
High blood pressure (mother) 0.9 1.3 5.6 0.0 0.0 -0.1 -1.5 2.4 -0.1
Body mass index (BMI) 0.7 3.1 9.2 -1.2 1.2 1.4 -1.6 3.0 -1.4
Impedance of leg (left) 0.1 0.5 1.1 0.6 -0.6 -0.7 0.8 -0.2 1.1
Leg predicted mass (left) 0.2 1.0 2.4 1.5 -1.5 -1.1 -0.1 0.2 0.7
Trunk fat mass 0.2 0.9 4.7 0.4 -0.4 0.1 -0.8 2.2 -0.1
Waist circumference 0.3 1.0 4.0 0.9 -0.8 -0.3 -0.7 2.0 0.0
Number of incorrect matches in round 0.3 0.6 1.1 -0.7 0.8 0.8 -0.6 -0.4 -1.1
Past tobacco smoking 2.6 4.7 6.5 -2.4 2.5 2.5 -2.2 1.1 -1.9
Alcohol usually taken with meals 0.1 0.1 0.2 -0.3 0.2 0.5 -0.4 0.3 0.2
Nervous feelings 1.2 2.3 4.3 -1.1 1.1 1.2 -2.1 1.6 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.2 0.1 0.0 0.2 -0.2 0.4 -0.2
Hearing difficulty/problems with background noise 2.9 4.6 9.6 1.9 -1.9 -2.1 3.1 -1.6 2.0
Hair/balding pattern: Pattern 2 0.6 0.7 1.7 1.0 -0.8 -0.8 1.3 0.5 0.5
Had menopause 1.7 2.2 12.1 0.2 -0.3 -0.5 0.7 -3.5 0.2
Had other major operations 1.0 1.2 6.1 0.1 -0.2 -0.6 0.8 -2.5 0.3
Forced vital capacity (FVC) 1.6 6.0 8.5 2.9 -2.9 -2.8 1.2 -1.6 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.4 -1.1 1.3 1.9 -1.6 1.3 -1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 -0.6 0.7 0.5 0.1 -1.4 -0.8
Qualifications: None of the above 0.3 0.6 3.1 -0.1 0.1 -0.3 0.4 1.8 0.0
Financial difficulties in last 2 years 0.8 1.1 5.2 0.2 -0.2 -0.7 0.7 2.3 0.6
Mouth/teeth dental problems 0.5 0.7 3.0 0.6 -0.4 -0.1 -0.8 -1.7 0.4
Heart attack 0.0 0.0 0.1 -0.3 0.1 -0.1 -0.1 -0.2 0.2
Allergy 0.8 1.9 2.6 1.2 -1.4 -1.3 1.6 1.2 1.6
Pain all over the body in last month 0.1 0.1 0.2 -0.2 0.2 0.5 -0.1 -0.5 -0.5
Diabetes (self-reported) 0.4 0.6 3.0 -0.2 0.1 -0.2 -0.5 1.7 0.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 4.4 1.2 -1.3 -1.0 -0.0 -2.1 1.5
Medication: Ramipril 0.4 0.5 2.4 0.0 -0.0 -0.0 -0.7 1.5 0.2
Medication: Simvastatin 1.2 1.8 6.3 -0.8 1.0 0.9 -1.2 2.5 -0.8
Fluid intelligence score 0.6 1.2 1.7 -0.9 0.9 1.2 -1.3 1.2 -0.9
Illnesses of siblings 0.8 1.1 1.4 1.2 -1.0 -1.1 0.8 -1.2 0.9
Neuroticism score 0.1 0.1 0.4 0.6 -0.6 -0.3 0.0 0.0 0.0
Weight 0.2 1.0 2.4 1.1 -1.1 -0.7 -0.4 1.6 0.5
Impedance of arm (right) 0.0 0.2 0.5 0.1 -0.1 -0.4 0.6 -0.7 0.3
Arm fat percentage (right) 0.7 2.9 11.6 -1.0 0.9 1.1 -1.3 3.4 -1.2
Trunk fat-free mass 0.5 3.0 5.8 2.4 -2.3 -2.0 0.5 -0.7 1.5
Hip circumference 0.3 1.1 3.1 1.2 -1.2 -0.7 0.2 1.8 0.6
Time employed in main current job 1.0 1.1 1.7 -1.0 0.9 1.3 -0.9 1.0 -1.1
Alcohol intake versus 10 years previously 0.1 0.1 0.5 0.3 -0.3 -0.7 0.4 0.3 0.1
Father’s age at death 0.1 0.2 0.4 0.4 -0.4 -0.5 0.7 0.1 0.3
Worrier / anxious feelings 0.3 0.6 1.3 -0.6 0.7 0.7 -0.9 0.2 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.9 -0.9 -0.6 0.6 -0.5 0.6
Falls in the last year 0.8 1.0 3.7 0.9 -0.9 -0.5 0.1 -1.9 0.8
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.1 -0.2 -0.4 -0.4 0.4 0.5
Number of live births 1.1 1.5 2.1 -1.2 1.4 1.2 -0.9 1.5 -1.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 2.3 1.5 -1.4 -1.5 0.2 0.5 1.5
Pulse rate 1.1 1.8 2.5 1.6 -1.6 -1.3 1.3 -0.9 1.3
Happiness 0.4 0.5 0.7 -0.8 0.8 0.7 -0.8 0.3 -0.5
Noisy workplace 0.7 0.9 3.3 0.5 -0.6 -0.7 1.8 -0.5 0.9
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.2 0.2 -0.0 -0.5 0.2 -1.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.7 0.7 -0.7 -0.5 -0.3 -0.5 0.9
Mouth/teeth dental problems: Dentures 2.3 3.9 6.3 1.7 -2.0 -2.2 2.5 -0.3 2.2
Asthma 0.5 0.9 2.5 -0.5 0.7 1.0 -1.6 0.1 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 3.1 0.8 -0.7 -0.9 1.8 0.4 1.3
Medication: Cholesterol lowering 2.0 3.0 4.8 -1.7 1.6 1.6 -2.2 1.7 -1.6
Depression (self-reported) 0.6 0.8 3.8 -0.6 0.3 -0.3 0.2 2.0 -0.5
Medication: Lansoprazole 0.8 0.9 1.5 0.9 -0.9 -0.9 0.7 -1.2 0.9
Prospective memory result 0.1 0.1 0.2 0.4 -0.3 -0.0 0.2 -0.2 0.1
Lung cancer (father) 0.3 0.4 1.0 -0.3 0.4 0.4 -0.4 1.0 -0.7
Illnesses of mother 0.1 0.1 0.4 -0.3 0.3 0.1 0.7 -0.5 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.1 0.5 -0.6 -0.6 -0.6 1.0 0.6
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 0.4 -0.5 -0.5 -1.1 0.6 0.8
Impedance of arm (left) 0.1 0.5 1.2 0.6 -0.6 -0.4 0.8 -1.1 0.6
Arm fat mass (right) 0.3 1.3 7.1 0.0 -0.0 0.3 -0.9 2.7 -0.4
Trunk predicted mass 0.6 3.4 6.4 2.5 -2.4 -2.1 0.6 -0.8 1.7
Standing height 1.5 15.2 22.8 4.8 -4.6 -4.2 2.4 -2.9 3.8
Length of working week for main job 1.2 1.4 2.0 -1.4 1.2 1.3 -1.2 0.8 -1.0
Exposure to tobacco smoke at home 0.5 0.5 1.0 0.9 -1.0 -0.6 0.3 0.2 0.8
Breastfed as a baby 0.0 0.1 0.1 -0.4 0.2 0.0 0.3 -0.3 -0.2
Tense / ‘highly strung’ 0.4 0.7 2.0 -0.6 0.7 0.5 -1.1 0.1 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.2 -0.3 -0.4 0.3 0.2 0.3
Hair/balding pattern: Pattern 4 0.1 0.2 0.6 -0.2 0.1 0.0 -0.1 -0.8 0.7
Birth weight of first child 0.9 1.7 3.3 1.1 -1.3 -1.5 1.2 -1.8 0.8
Peak expiratory flow (PEF) 1.1 2.6 4.9 -1.2 1.2 1.1 -2.2 1.9 -1.6
Pulse wave reflection index 0.8 1.0 2.7 -0.9 0.7 0.6 -1.6 1.2 -0.2
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.6 0.6 -0.6 -0.8 1.3 -1.6 0.7
Loud music exposure frequency 0.9 1.0 2.2 1.1 -1.0 -1.2 1.5 0.1 0.6
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.2 0.4 -0.3 -0.1 -0.3 0.1 0.2
Mouth/teeth dental problems: Bleeding gums 2.6 3.3 9.3 -1.5 1.6 1.5 -1.2 3.0 -1.5
Blood clot in the leg (DVT) 0.9 1.2 2.0 -1.0 1.2 1.4 -0.9 -0.2 -1.3
Medication: Paracetamol 0.3 0.6 1.7 0.6 -0.5 -0.8 1.3 0.1 0.7
Headache pain in last month 0.1 0.2 0.5 0.0 0.0 -0.1 0.7 0.5 -0.4
Medication for cholesterol, blood pressure or diabetes 2.3 3.7 6.2 2.0 -1.8 -1.8 2.5 -1.9 1.4
Glaucoma (self-reported) 2.9 3.4 6.4 1.7 -1.7 -1.6 1.9 -2.5 1.4
Gout (self-reported) 0.9 1.2 1.8 -1.1 1.1 1.2 -1.3 0.6 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.2 0.9 -1.0 -0.6 0.8 -1.1 0.7
Medication: Amlodipine 2.0 2.8 4.1 -1.7 1.8 1.8 -1.7 0.7 -2.0
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.7 0.2 -0.0 0.3 -0.4 -0.6 -0.8
Birth weight 2.5 5.4 7.3 2.6 -2.7 -2.3 2.2 -2.1 1.9
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.7 -0.1 -0.0 0.4 0.6 -1.3 0.2
High blood pressure (siblings) 0.7 1.1 1.5 -1.1 1.1 1.2 -1.2 -0.2 -1.0
Forced vital capacity (FVC), Best measure 0.5 1.7 2.5 1.5 -1.6 -1.5 0.3 -0.9 1.4
Body fat percentage 0.4 1.7 8.4 -0.4 0.3 0.7 -1.1 2.9 -0.6
Leg fat percentage (right) 0.9 3.4 14.2 -1.0 1.0 1.1 -1.6 3.8 -0.9
Arm fat-free mass (right) 0.5 2.4 5.2 2.3 -2.2 -1.6 0.3 -0.3 1.4
Exposure to tobacco smoke outside home 0.7 1.0 1.7 1.3 -1.1 -1.0 0.9 -0.2 1.0
Comparative body size at age 10 5.2 14.4 23.5 -3.8 3.5 3.7 -3.5 4.8 -3.2
Number of full brothers 0.1 0.1 0.4 0.1 -0.2 0.1 -0.2 -0.7 0.2
Worry too long after embarrassment 0.4 0.7 1.3 0.8 -0.9 -1.1 0.8 -0.7 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 2.5 1.5 -1.5 -1.4 1.6 0.1 1.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 0.7 -0.6 -0.2 -0.4 -0.3 0.0
Number of children fathered 0.2 0.3 0.7 0.1 -0.2 -0.8 0.6 0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 4.0 0.3 -0.4 -0.6 0.6 -2.0 0.4
Age at first live birth 0.1 0.2 0.6 -0.4 0.3 0.2 0.1 0.2 -0.7
Pulse wave peak to peak time 0.3 0.4 1.2 -0.2 0.3 0.3 1.1 -0.6 -0.6
Health satisfaction 1.8 2.4 3.0 1.6 -1.6 -1.6 1.7 -0.9 1.7
Shortness of breath walking on level ground 4.8 5.7 7.7 2.7 -2.8 -2.5 2.4 -0.5 2.7
Qualifications: College or University degree 0.5 1.5 9.1 -0.0 0.0 -0.1 0.3 -3.0 -0.0
Eye problems/disorders: None of the above 2.3 2.7 8.0 -1.4 1.0 0.6 -1.8 2.8 -1.2
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.4 -0.6 0.6 0.3 0.3 0.1 -0.2
Emphysema/chronic bronchitis 0.3 0.4 0.7 0.8 -0.8 -0.5 0.4 -0.5 0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.4 -0.6 0.5 0.6 -0.6 -0.4 -0.6
Neck or shoulder pain in last month 0.6 0.8 3.8 0.4 -0.4 -0.5 0.7 1.9 0.1
Medication: Blood pressure 3.0 5.3 10.4 -2.3 2.2 2.4 -3.2 1.5 -1.8
Angina (self-reported) 2.3 3.1 5.2 -2.3 2.1 1.9 -1.3 1.2 -1.4
Migraine (self-reported) 1.2 1.4 2.3 1.0 -1.0 -1.1 1.4 -1.5 1.1
Medication: Ibuprofen 1.5 1.9 3.9 1.3 -1.2 -1.2 2.0 -0.1 1.6
Medication: Allopurinol 0.1 0.1 0.2 -0.1 0.1 0.3 -0.4 -0.5 0.0
Medication: Omeprazole 0.7 0.8 1.8 -0.4 0.5 0.7 -1.3 1.4 -0.6
Medication: Seretide 50 evohaler 1.1 1.2 1.8 -0.8 1.2 1.2 -1.3 0.9 -1.2
Mean time to correctly identify matches 1.3 2.5 5.4 1.2 -1.4 -1.7 2.3 0.3 1.8
Heart disease (mother) 0.2 0.3 0.7 -0.3 0.1 -0.3 0.8 -0.8 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.9 4.6 5.2 -2.2 2.3 2.3 -2.3 1.9 -2.0
Whole body fat mass 0.3 1.3 7.0 0.4 -0.4 0.1 -0.8 2.7 -0.0
Leg fat mass (right) 0.4 1.6 8.6 0.1 -0.1 0.2 -0.9 2.9 -0.2
Arm predicted mass (right) 0.5 2.5 5.3 2.3 -2.2 -1.6 0.4 -0.3 1.5
Pulse rate, automated reading 0.2 0.7 1.6 1.2 -1.3 -0.7 0.1 -0.2 0.5
Alcohol intake frequency. 0.6 1.4 2.6 -1.0 1.0 1.1 -1.2 1.6 -1.0
Comparative height size at age 10 1.8 10.0 14.7 3.8 -3.8 -3.5 2.3 -0.9 3.5
Number of full sisters 1.6 1.9 2.8 1.7 -1.6 -1.3 1.7 -0.6 1.3
Suffer from ‘nerves’ 0.2 0.3 0.8 -0.6 0.4 0.3 -0.7 0.9 -0.2
Overall health rating 0.2 0.5 1.8 -0.3 0.4 0.6 -0.4 1.3 -0.7
Chest pain or discomfort 0.2 0.3 1.7 0.4 -0.3 0.2 -0.1 1.3 0.2
Had major operations 0.0 0.0 0.2 -0.1 0.1 0.1 0.2 -0.0 0.4
Age at last live birth 2.0 2.9 5.8 -1.7 1.7 1.8 -1.5 0.7 -2.4
Family relationship satisfaction 0.1 0.1 0.3 -0.3 0.4 0.4 -0.6 0.2 -0.3
Leg pain on walking 1.5 1.9 3.0 1.7 -1.6 -1.1 1.1 -1.2 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 0.5 -0.6 -0.2 0.2 -0.5 0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.5 -0.7 0.6 0.6 -0.6 -0.3 -0.7
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.6 -1.2 1.3 1.6 -0.8 -0.4 -1.3
Medication: Aspirin 0.5 0.6 0.8 0.8 -0.9 -0.8 0.6 -0.6 0.9
Supplements: Vitamin C 0.1 0.1 0.5 -0.0 0.0 -0.1 0.3 -0.7 -0.2
Knee pain experienced in last month 0.3 0.4 0.8 -0.7 0.8 0.9 -0.1 0.3 -0.8
Hypertension (Self-reported) 1.0 2.7 5.3 -1.3 1.3 1.5 -2.3 1.8 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.5 2.0 1.3 -1.4 -1.1 1.2 -0.6 1.3
Illnesses of father: Heart disease 2.3 3.1 3.6 -1.9 1.8 1.9 -1.8 1.6 -1.6
Illnesses of siblings: Diabetes 0.3 0.4 1.0 0.3 -0.5 -1.0 0.6 0.4 0.6
Smoking status: Previous 2.5 3.7 4.5 1.8 -2.0 -2.1 1.9 -2.1 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.0 1.0 -1.0 -0.7 -0.2 -0.5 0.3
Whole body fat-free mass 0.3 1.9 4.0 2.0 -1.9 -1.5 0.2 -0.2 1.1
Leg fat-free mass (right) 0.2 1.2 2.9 1.7 -1.6 -1.1 0.1 0.0 0.7
Arm fat percentage (left) 0.6 2.5 10.7 -0.7 0.7 1.0 -1.2 3.3 -1.0
Average weekly red wine intake 0.8 1.2 4.2 0.8 -0.8 -0.6 1.2 -2.0 0.3
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.7 0.0 0.0 -0.2 -0.2 -0.9 0.5
Mood swings 0.3 0.6 1.6 1.3 -1.1 -0.6 0.2 -0.5 0.2
Loneliness, isolation 1.4 1.9 3.1 -1.1 1.2 1.3 -1.4 1.8 -1.5
Long-standing illness, disability or infirmity 0.5 0.7 1.1 0.9 -0.9 -1.1 0.8 0.7 0.7
Ever had bowel cancer screening 1.5 1.7 2.3 -1.2 1.2 1.5 -1.5 1.1 -1.2
Diabetes diagnosed by doctor 0.3 0.5 2.4 -0.3 0.2 0.1 -0.7 1.6 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 -0.5 0.6 0.5 -0.5 -0.9 -1.1
Friendships satisfaction 0.1 0.1 0.3 -0.5 0.5 0.3 -0.1 0.3 -0.2
Qualifications: nursing, teaching 0.1 0.2 0.3 -0.5 0.5 0.1 -0.4 -0.6 -0.3
Commuting to job workplace: Walk 4.7 5.1 7.1 2.5 -2.4 -2.5 2.3 -0.1 2.7
Eye problems/disorders: Cataract 0.3 0.4 0.9 -0.3 0.6 0.9 -0.5 -0.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 3.8 -1.6 1.7 1.8 -1.1 0.7 -2.0
Medication for cholesterol 0.0 0.0 0.1 0.0 -0.1 -0.3 0.3 -0.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.1 -1.0 1.2 1.4 -0.8 0.8 -1.0
Back pain experienced in last month 3.1 4.5 6.2 2.4 -2.5 -2.3 2.1 -0.6 2.2
Mineral and other dietary supplements 0.4 0.5 1.8 0.4 -0.4 -0.3 -0.6 1.4 0.7
Breast cancer (self-reported) 0.5 0.6 1.3 0.1 -0.4 -1.1 0.1 -1.1 0.8
Asthma (self-reported) 0.4 0.8 2.2 -0.4 0.6 0.9 -1.5 0.1 -1.1
Osteoporosis (self-reported) 0.3 0.4 0.8 -0.4 0.5 0.7 -0.9 0.3 -0.6
Osteoarthritis (self-reported) 0.3 0.3 1.0 0.4 -0.5 -0.3 0.7 -1.0 0.3
Medication: Aspirin 0.0 0.1 0.1 0.3 -0.3 -0.2 0.1 -0.3 0.2
Medication: Gliclazide 2.7 3.0 4.2 -1.6 1.7 1.9 -2.1 1.1 -1.9
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.1 0.2 0.3 -0.6 0.6 -0.5
Smoking status: Current 0.9 1.4 2.2 1.5 -1.3 -1.3 0.9 0.8 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.0 -1.2 1.1 1.0 -1.0 1.4 -1.1
Whole body water mass 0.3 1.7 3.7 1.9 -1.8 -1.4 0.1 -0.2 1.1
Leg predicted mass (right) 0.2 1.2 2.9 1.7 -1.6 -1.1 0.0 0.1 0.7
Arm fat mass (left) 0.4 1.5 7.4 -0.2 0.1 0.5 -1.0 2.7 -0.6
Number of self-reported non-cancer illnesses 0.1 0.2 0.7 -0.1 0.1 0.2 -0.9 0.5 -0.2
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.5 -0.4 -0.7 0.5 0.2 0.7
Miserableness 0.0 0.0 0.2 0.1 -0.1 -0.0 0.1 -0.4 -0.2
Guilty feelings 1.8 2.8 3.5 1.8 -1.9 -1.7 1.8 -1.5 1.4
Wears glasses or contact lenses 1.5 1.7 3.2 1.0 -1.1 -1.1 1.5 -1.8 1.1
Ever taken oral contraceptive pill 1.1 1.2 1.7 -1.3 1.3 1.1 -0.8 0.8 -1.1
Hearing aid user 0.2 0.2 0.8 -0.4 0.5 0.0 -0.1 0.9 0.1
Mother’s age at death 0.1 0.1 0.1 0.2 -0.2 -0.1 0.1 0.4 0.4
Financial situation satisfaction 1.2 1.4 2.4 1.3 -1.4 -1.6 1.2 -0.1 1.0
Tinnitus: Yes, now most or all of the time 1.7 2.0 4.7 1.0 -1.0 -1.4 2.2 -0.1 1.7
Commuting to job workplace: Public transport 1.0 1.2 1.5 0.9 -1.0 -1.1 1.2 1.2 1.2
Eye problems/disorders: Glaucoma 3.8 4.5 7.6 2.0 -1.9 -1.9 2.3 -2.8 1.7
Medication: Blood pressure 0.3 0.6 1.3 0.8 -0.8 -0.5 -0.2 1.1 0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.6 -0.6 -0.5 0.2 0.3 0.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.6 0.6 -0.6 -0.8 1.0 -1.9 0.4
High cholesterol (Self-reported) 0.7 1.2 6.2 -0.2 0.4 0.4 -0.7 2.5 -0.2
Medication: Bendroflumethiazide 0.4 0.6 2.0 -0.5 0.4 1.0 -1.4 0.1 -0.6
Medication: Paracetamol 0.1 0.1 0.5 -0.1 0.2 -0.3 0.7 0.0 0.2
Medication: Lisinopril 0.7 0.9 1.5 1.1 -1.2 -0.8 -0.3 0.4 1.2
Medication: Atorvastatin 1.6 1.9 3.7 -1.1 1.1 1.6 -1.9 -0.6 -1.6
Illnesses of father: High blood pressure 0.3 0.4 1.8 0.2 -0.3 -0.1 0.4 1.3 0.3
Alcohol drinker status: Never 1.7 2.0 2.8 1.7 -1.7 -1.4 1.5 0.2 1.6
Ever smoked 0.7 1.3 2.2 1.4 -1.5 -1.4 0.9 0.3 1.0
Basal metabolic rate 0.3 1.7 3.6 1.9 -1.8 -1.4 0.1 0.2 1.1
Leg fat percentage (left) 0.9 3.4 14.1 -0.9 0.9 1.1 -1.5 3.8 -0.9
Arm fat-free mass (left) 0.3 1.7 3.5 1.9 -1.8 -1.4 0.1 0.2 1.2
Number of operations (self-reported) 0.2 0.2 0.9 -0.5 0.3 -0.0 0.4 -0.9 -0.2
Average weekly beer plus cider intake 0.2 0.4 1.1 0.3 -0.2 -0.2 0.9 -1.0 -0.2
Irritability 1.8 3.1 5.1 -1.7 1.8 1.7 -2.1 -0.4 -2.2
Risk taking 1.3 2.0 4.0 1.3 -1.5 -1.5 2.0 -0.8 0.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.8 -0.2 0.1 0.2 -0.7 0.9 -0.0
Fractured/broken bones in last 5 years 0.0 0.0 0.1 0.2 -0.3 0.0 0.1 0.1 -0.1
Age started oral contraceptive pill 0.1 0.2 0.4 -0.5 0.5 0.6 0.1 -0.1 -0.3
Diastolic blood pressure, automated reading 0.9 2.8 3.8 1.7 -1.7 -1.6 1.9 0.9 1.9
Ever depressed for a whole week 0.2 0.2 1.3 -0.1 0.3 0.1 -0.1 -1.1 -0.2
Unable to work because of sickness or disability 1.3 1.7 2.4 1.5 -1.5 -1.6 1.1 0.4 1.4
Commuting to job workplace: Cycle 2.7 3.3 5.5 1.8 -1.6 -1.9 2.1 -0.4 2.3
Myopia 0.3 0.5 2.0 -0.1 -0.1 -0.4 1.4 -0.7 0.4
Vascular/heart problems diagnosed by doctor 1.0 2.6 5.2 1.3 -1.3 -1.6 2.3 -1.6 1.4
Cholesterol lowering medication 0.7 1.0 4.4 -0.5 0.7 0.7 -0.6 2.1 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 1.2 -1.1 -1.0 0.3 0.3 1.1
Pain experienced in last month 1.6 2.7 3.2 -1.7 1.8 1.6 -1.7 -1.8 -1.1
Supplements: Calcium 1.6 1.8 2.7 1.2 -1.3 -1.4 1.5 -0.6 1.6
Basal cell carcinoma (self-reported) 2.1 2.5 4.1 -1.9 1.8 1.4 -1.5 -0.0 -2.0
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.4 -0.6 0.3 0.1 -0.3 -0.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 1.9 -1.0 1.2 1.4 -0.9 -0.1 -1.4
Heart disease (siblings) 1.1 1.4 4.2 -0.9 0.8 1.1 -0.8 2.0 -1.0
Alcohol drinker status: Previous 1.5 1.7 2.2 -1.3 1.3 1.5 -1.1 1.0 -1.5
Pack years of smoking 0.5 0.8 1.5 1.1 -1.2 -0.8 0.2 -0.3 1.1
Impedance of whole body 0.1 0.7 1.0 0.7 -0.7 -0.7 0.9 -0.9 1.0
Leg fat mass (left) 0.4 1.7 9.1 0.1 -0.1 0.3 -1.0 3.0 -0.3
Arm predicted mass (left) 0.3 1.6 3.5 1.9 -1.8 -1.4 0.1 0.2 1.1