Hub : Genes

CDIPT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.088 0.049 0.00540 0.040 NA 0.001 NA 0.017 3.0e-03 NA 2.8e-01 NA 3.6e-02
2 GTEx Brain Cerebellum 0.236 0.079 0.00062 0.169 NA 0.178 NA 0.175 1.1e-05 NA 6.2e-06 NA 7.4e-06
3 GTEx Esophagus Muscularis 0.059 0.030 0.00280 0.043 NA 0.019 NA 0.046 1.2e-03 NA 2.3e-02 NA 8.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.7 3.5 -1.1 1.9 -0.7
Bipolar Disorder or Schizophrenia 3.3 7.9 12.8 -1.9 2.7 -3.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 0.5 0.5 -0.0
Depression (Nagel 2018) 0.5 0.8 2.1 -0.5 0.0 -1.4
Intelligence (Savage-Jansen 2018) 0.7 2.1 2.9 1.7 -1.4 1.3
Neuroticism (Nagel 2018) 0.9 2.1 4.1 -0.5 1.4 -2.0
Schizophrenia (2018) 2.9 6.1 12.1 -1.6 1.9 -3.5
Schizophrenia vs Biploar Disorder 0.5 0.7 1.2 0.3 -1.0 -1.1
Worry (Nagel 2018) 4.7 10.0 19.1 -2.0 2.6 -4.4
Alzheimer’s Disease (in mother) 3.2 3.8 7.3 -1.7 1.1 -2.7
Alzheimer’s Disease (in father) 0.2 0.3 0.5 0.4 0.7 -0.3
Alzheimer’s Disease (including proxy) 3.5 5.1 8.7 -2.0 1.6 -3.0
Crohns Disease (2017) 0.2 0.4 0.8 0.3 0.7 -0.9
Irritable Bowel Disease (IBD) 0.2 0.4 1.1 0.2 0.1 -1.1
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.3 -0.5 -0.5
Major Depression (MDD) 0.5 0.6 1.9 0.0 0.0 -1.4
Reaction Time 0.3 0.6 1.4 0.0 -1.2 -0.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.2 0.8 -1.1 0.9
Breast Cancer 0.3 0.6 1.6 1.3 0.4 -0.3
Ovarian Cancer 0.1 0.1 0.2 -0.0 0.4 -0.3
Prostate Cancer 1.1 1.6 2.6 1.0 -1.1 -1.6
Age at First Birth 0.4 0.6 1.1 1.0 -0.8 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.8 3.9 8.9 1.3 -1.0 3.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.6 1.0 1.8 0.1 1.1 -1.3
Mean Putamen Volume 0.1 0.1 0.1 0.4 -0.2 -0.0
Fasting Glucose 0.9 1.1 1.6 -0.7 1.1 -1.3
HbA1C 0.3 0.4 1.0 -0.3 0.2 1.0
HDL Cholesterol 0.8 1.3 1.6 -1.3 1.1 -1.0
LDL Cholesterol 1.3 2.1 4.2 -1.4 -0.2 -2.1
Lupus 1.7 2.6 7.7 -2.8 0.5 -0.2
Neuroticism (2016) 0.5 0.8 1.6 0.9 -0.2 -1.2
Primary Biliary Cirrhosis 0.5 0.7 1.8 0.5 0.1 1.4
Rheumatoid Arthritis 0.8 1.2 3.2 1.8 -0.5 0.2
Schizophrenia (2014) 3.3 7.3 14.7 -1.4 2.3 -3.8
Triglycerides 0.1 0.1 0.2 0.4 0.1 0.5
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.0 0.0 0.1 0.3 -0.1 0.2
Blood Eosinophil Count 5.3 40.9 108.2 -3.8 0.7 -10.4
Blood Platelet Count 0.6 7.1 9.9 -1.8 -2.9 -3.1
Blood Red Count 10.7 103.0 289.0 -4.4 0.6 -17.0
Blood White Count 1.9 14.1 17.7 -4.2 2.9 -4.0
Heel T-Score 1.8 14.0 20.9 -2.3 4.0 -4.6
BMI 9.6 55.7 82.3 6.9 -6.0 9.1
Height 2.6 49.4 80.1 7.4 -3.7 8.9
Waist Hip Ratio (WHR) 1.9 8.6 14.4 3.4 -3.8 -0.5
Systolic Blood Pressure 0.6 2.9 5.3 2.3 -1.1 1.5
Smoking Status 0.2 0.4 0.7 -0.4 0.8 0.7
Allergy or Eczema 1.2 3.1 7.3 -2.7 1.3 0.5
Cardiovascular Disease 0.8 2.8 5.2 1.7 -2.3 0.3
Hypothyroidism (self reported) 0.0 0.1 0.2 -0.1 0.4 -0.2
Respiratory disease 2.3 5.1 12.3 1.4 -0.9 3.5
Type 2 Diabetes (T2D) (2018) 1.6 2.9 3.3 1.8 -1.5 1.8
Lung FEV1/FVC ratio 2.0 10.0 28.9 -1.0 0.4 -5.4
Lung FVC 0.3 1.5 2.9 -1.1 1.7 -0.6
Neuroticism 0.4 1.0 2.3 0.6 0.6 -1.5
Chronotype (morning person) 3.1 7.2 11.2 3.3 -1.9 2.6
Hair Pigment 0.0 0.2 0.5 -0.7 -0.1 -0.2
Tanning 0.3 3.4 3.7 -1.7 1.9 -1.9
Hand grip strength (left) 3.4 8.8 16.7 3.1 -0.3 4.1
Number of treatments/medications taken 0.4 0.8 2.3 1.5 0.0 0.2
Average weekly spirits intake 1.0 1.2 2.7 -1.6 1.0 -0.1
Sensitivity / hurt feelings 0.9 1.5 2.7 -1.1 0.8 -1.6
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.4 -0.6 0.3 -1.2
Hearing difficulty/problems: Yes 0.1 0.2 0.4 0.5 -0.7 0.0
Relative age of first facial hair 1.7 3.5 6.9 -0.2 1.9 -2.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.5 -0.8 1.2 -0.6
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 0.2 -0.0 0.1
Ever had hysterectomy (womb removed) 1.7 1.9 4.6 -0.8 0.6 -2.1
Systolic blood pressure, automated reading 0.2 0.6 1.2 1.1 -0.9 0.2
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 0.0 -0.1 0.2
Angina 2.2 2.9 4.2 2.1 1.5 1.5
Medication for hormone replacement therapy 0.9 1.0 1.5 0.8 1.2 -1.0
Vitamin and mineral supplements 0.4 0.5 1.5 -0.2 -0.1 -1.2
Supplements: Zinc 0.5 0.6 1.1 0.3 -0.7 1.1
Medication: Co-codamol 1.4 1.6 3.1 1.8 -1.1 0.8
Medication: Metformin 0.8 1.2 2.8 0.8 0.1 1.7
Diabetes (father) 5.3 6.5 15.1 0.3 -2.1 3.9
Diabetes (mother) 7.8 10.0 15.2 3.9 -3.7 1.2
Severe depression (siblings) 0.4 0.5 0.7 0.8 -0.8 -0.1
Pack years adult smoking proportion 0.4 0.6 0.9 -1.0 -0.6 -0.6
Impedance of leg (right) 8.4 40.7 74.1 -5.6 4.1 -8.6
Leg fat-free mass (left) 12.6 66.6 112.4 7.8 -5.2 10.6
Trunk fat percentage 4.5 18.2 21.7 3.7 -4.3 4.7
Hand grip strength (right) 2.1 5.7 13.1 2.0 -0.2 3.6
Townsend deprivation index at recruitment 0.4 0.6 1.5 1.2 -0.6 0.1
Current tobacco smoking 0.0 0.1 0.1 -0.1 0.3 0.3
Average weekly fortified wine intake 4.0 4.7 9.2 -3.0 1.2 -1.9
Maternal smoking around birth 1.2 1.7 3.8 -1.1 2.0 0.2
Fed-up feelings 0.8 1.5 2.3 1.3 0.5 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.5 0.8 -1.2 -0.3
Relative age voice broke 3.5 5.3 9.5 -0.5 2.5 -3.1
Taking other prescription medications 0.1 0.2 0.4 0.6 -0.1 0.5
Age when periods started (menarche) 7.9 18.9 26.5 -5.2 3.6 -4.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.3 -0.6 -0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.3 0.1 1.8 -0.9
Tinnitus: Yes, but not now, but have in the past 2.9 3.1 5.7 -1.4 2.4 1.3
Qualifications: CSEs or equivalent 2.0 2.6 3.5 1.0 1.9 1.8
Serious illness, injury or assault to yourself 1.2 1.5 2.3 1.5 -0.8 1.2
High blood pressure 1.6 4.4 6.3 2.5 -2.4 1.0
Hayfever, allergic rhinitis or eczema 1.4 3.0 5.2 -2.3 0.9 1.8
Multivitamins +/- minerals 1.2 1.6 3.6 0.9 0.5 1.9
Stomach or abdominal pain in last month 0.2 0.3 0.6 0.3 0.1 -0.8
Supplements: Glucosamine 1.0 1.2 3.3 -0.6 0.2 1.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 0.1 -0.1 -1.3
Medication: Atenolol 0.2 0.2 0.4 0.6 -0.4 0.1
Medication: Levothyroxine sodium 0.8 1.4 2.8 1.0 -1.7 0.4
Sitting height 0.7 5.3 10.2 3.2 -1.6 1.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.2 1.1 -0.6 -0.8
High blood pressure (mother) 1.9 2.7 6.3 1.1 -0.7 2.5
Body mass index (BMI) 9.8 41.6 64.8 5.7 -5.3 8.0
Impedance of leg (left) 7.8 37.7 67.1 -5.6 3.9 -8.2
Leg predicted mass (left) 12.8 67.8 114.5 7.9 -5.2 10.7
Trunk fat mass 8.6 36.9 50.8 5.6 -5.3 7.1
Waist circumference 14.9 54.7 63.2 7.1 -7.1 8.0
Number of incorrect matches in round 9.4 15.6 36.7 -2.6 1.8 -6.1
Past tobacco smoking 0.0 0.0 0.1 -0.2 0.3 0.0
Alcohol usually taken with meals 1.2 1.9 3.3 0.6 -1.4 1.8
Nervous feelings 7.1 13.2 25.8 -1.8 3.2 -5.1
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 7.0 -1.1 1.8 -2.6
Hearing difficulty/problems with background noise 0.5 0.8 1.3 0.8 -0.6 -1.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 -0.5 0.9 -0.0
Had menopause 1.2 1.4 3.9 0.4 -2.0 -0.5
Had other major operations 0.2 0.2 0.5 0.4 -0.1 0.7
Forced vital capacity (FVC) 1.6 6.3 13.0 2.4 0.0 3.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.8 -0.7 2.0 -0.0
Ever unenthusiastic/disinterested for a whole week 3.0 3.6 10.4 -0.4 0.6 -3.2
Qualifications: None of the above 0.3 0.6 1.2 0.6 -0.4 -1.1
Financial difficulties in last 2 years 0.8 1.1 1.7 1.1 0.6 1.3
Mouth/teeth dental problems 1.3 2.0 3.0 -1.7 0.9 -1.4
Heart attack 0.0 0.1 0.1 0.2 -0.4 0.1
Allergy 0.9 2.1 3.7 1.0 -1.2 -1.9
Pain all over the body in last month 1.7 1.8 4.7 2.2 -0.0 0.8
Diabetes (self-reported) 0.5 0.7 1.1 1.0 -0.2 1.1
Hayfever/allergic rhinitis (self-reported) 2.8 3.7 6.6 -2.6 1.3 -1.7
Medication: Ramipril 1.4 1.7 2.6 1.1 -1.6 1.2
Medication: Simvastatin 1.3 1.8 5.2 -0.4 -0.4 -2.3
Fluid intelligence score 0.5 1.1 2.8 -0.7 0.3 1.7
Illnesses of siblings 0.8 1.1 2.7 -0.7 1.6 0.1
Neuroticism score 0.6 1.2 2.3 1.0 0.5 -1.5
Weight 14.2 69.8 106.1 7.9 -6.4 10.3
Impedance of arm (right) 3.5 16.4 31.8 -3.6 2.2 -5.6
Arm fat percentage (right) 8.0 31.4 43.7 5.0 -5.0 6.6
Trunk fat-free mass 10.6 61.1 97.8 7.7 -5.1 9.9
Hip circumference 11.9 51.3 91.2 5.8 -5.4 9.6
Time employed in main current job 0.6 0.7 2.1 0.3 0.1 -1.5
Alcohol intake versus 10 years previously 5.1 7.7 13.7 3.7 -1.8 2.5
Father’s age at death 0.1 0.2 0.4 0.2 0.0 -0.7
Worrier / anxious feelings 3.6 6.7 11.8 -2.2 1.9 -3.4
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.7 0.3 -0.9
Falls in the last year 0.6 0.8 2.0 -0.3 0.5 1.4
Hair/balding pattern: Pattern 3 0.5 0.8 0.9 -0.9 0.8 -0.9
Number of live births 2.1 2.9 4.1 -1.7 1.3 -2.0
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 4.5 2.0 -0.5 2.1
Pulse rate 1.5 2.5 5.0 -2.2 0.9 -1.4
Happiness 0.5 0.6 1.0 -0.9 0.1 -1.0
Noisy workplace 0.0 0.0 0.1 -0.3 0.1 0.0
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.3 -0.7 -0.1 -1.2
Serious illness, injury or assault of a close relative in last 2 years 3.4 4.0 7.0 -0.2 2.2 2.6
Mouth/teeth dental problems: Dentures 1.8 3.1 3.3 1.8 -1.7 1.8
Asthma 2.9 5.7 14.1 1.5 0.9 3.8
Medication: Ibuprofen (e.g. Nurofen) 3.7 4.7 5.4 2.3 -1.9 2.2
Medication: Cholesterol lowering 0.8 1.2 2.4 -0.1 1.1 -1.5
Depression (self-reported) 1.1 1.3 3.5 0.7 -0.2 -1.9
Medication: Lansoprazole 0.2 0.2 0.6 0.3 0.8 0.1
Prospective memory result 1.2 1.5 2.8 0.6 -1.7 -1.2
Lung cancer (father) 0.9 1.0 1.7 1.3 -1.1 -0.2
Illnesses of mother 0.6 0.7 1.7 -0.4 0.4 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 0.8 0.9 0.8 0.8
Pulse wave Arterial Stiffness index 0.5 0.6 0.8 0.8 -0.9 -0.5
Impedance of arm (left) 4.3 20.1 35.4 -4.0 3.0 -6.0
Arm fat mass (right) 12.1 49.7 74.3 6.4 -5.8 8.6
Trunk predicted mass 10.7 61.0 98.0 7.7 -5.1 9.9
Standing height 2.9 28.7 39.3 5.8 -3.6 6.3
Length of working week for main job 0.4 0.4 0.8 0.5 -0.9 0.4
Exposure to tobacco smoke at home 2.4 2.7 4.5 1.4 -2.1 1.3
Breastfed as a baby 0.3 0.4 1.2 -0.2 -0.2 1.1
Tense / ‘highly strung’ 3.6 6.0 16.1 -0.3 1.4 -4.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 7.6 -0.5 1.4 -2.7
Hair/balding pattern: Pattern 4 0.3 0.7 1.3 1.2 -0.9 0.4
Birth weight of first child 0.5 0.9 2.0 0.8 -0.1 1.4
Peak expiratory flow (PEF) 0.6 1.5 2.4 1.6 -0.9 1.1
Pulse wave reflection index 0.5 0.6 1.2 1.1 -0.8 0.4
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.3 1.1 -0.8 1.5
Loud music exposure frequency 1.8 2.0 3.6 -1.5 1.9 0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.5 -0.8 -0.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.6 0.4 0.6 0.8
Blood clot in the leg (DVT) 0.4 0.5 0.9 0.4 -0.6 -0.9
Medication: Paracetamol 2.1 3.5 8.0 2.8 -1.6 0.0
Headache pain in last month 0.3 0.5 0.9 1.0 -0.6 -0.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.0 -0.6 -0.3 1.0
Glaucoma (self-reported) 1.7 2.0 5.1 1.0 0.1 2.3
Gout (self-reported) 0.3 0.4 1.0 -0.4 1.0 0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.4 0.6 -0.2 -0.6
Medication: Amlodipine 0.3 0.4 1.2 1.1 0.2 0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -0.0 0.2 1.2
Birth weight 0.5 1.1 2.0 1.0 0.5 1.4
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.9 -0.5 1.7 -1.2
High blood pressure (siblings) 0.5 0.7 1.3 1.1 -0.8 -0.3
Forced vital capacity (FVC), Best measure 1.1 4.1 8.5 1.8 0.9 2.9
Body fat percentage 5.0 19.6 23.7 3.9 -4.5 4.9
Leg fat percentage (right) 3.1 11.1 13.5 2.8 -3.4 3.7
Arm fat-free mass (right) 10.1 51.6 86.1 6.9 -4.6 9.3
Exposure to tobacco smoke outside home 0.3 0.3 0.8 -0.3 0.9 -0.4
Comparative body size at age 10 4.7 13.1 21.5 4.6 -3.1 2.9
Number of full brothers 0.2 0.3 0.8 0.9 -0.1 0.3
Worry too long after embarrassment 0.3 0.5 1.1 -0.4 0.6 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 3.4 4.5 11.1 -0.4 1.5 -3.3
Wheeze or whistling in the chest in last year 3.6 6.4 15.0 1.9 -0.6 3.9
Number of children fathered 2.6 3.0 8.3 0.8 -0.1 2.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.5 -0.7 1.2 -0.4
Age at first live birth 0.5 0.9 1.9 0.2 -1.4 0.9
Pulse wave peak to peak time 0.6 0.7 0.9 -0.6 0.8 0.9
Health satisfaction 1.8 2.3 4.3 2.1 -1.6 0.3
Shortness of breath walking on level ground 1.2 1.4 3.1 1.0 -1.8 0.2
Qualifications: College or University degree 1.3 4.0 7.2 -2.7 1.7 -1.4
Eye problems/disorders: None of the above 1.0 1.2 1.6 0.9 1.2 -1.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.7 -0.3 -0.3 1.3
Emphysema/chronic bronchitis 0.2 0.3 0.4 -0.6 -0.5 -0.4
Medication for pain relief, constipation, heartburn 3.2 5.5 10.8 -3.3 2.3 0.5
Neck or shoulder pain in last month 4.2 5.9 13.0 1.8 -1.3 3.6
Medication: Blood pressure 0.8 1.3 2.9 1.7 -0.7 0.8
Angina (self-reported) 1.9 2.5 2.7 1.6 1.6 1.4
Migraine (self-reported) 0.9 1.2 2.0 -1.4 -0.2 -1.2
Medication: Ibuprofen 1.5 1.8 2.7 1.3 -1.1 1.6
Medication: Allopurinol 0.3 0.4 1.3 0.2 1.1 0.0
Medication: Omeprazole 0.2 0.3 0.8 0.1 0.2 -0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.0 1.0 -0.7 0.5
Mean time to correctly identify matches 1.0 1.9 2.9 -0.6 -1.6 -1.7
Heart disease (mother) 0.2 0.3 0.7 0.5 0.0 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.4 -0.2 -0.2
Whole body fat mass 9.6 40.2 57.0 5.7 -5.6 7.5
Leg fat mass (right) 8.2 31.9 49.1 5.0 -4.6 7.0
Arm predicted mass (right) 10.4 53.3 88.5 7.0 -4.8 9.4
Pulse rate, automated reading 0.2 0.6 1.4 -1.2 -0.5 -0.4
Alcohol intake frequency. 9.2 21.4 36.9 6.1 -3.9 3.5
Comparative height size at age 10 4.5 25.0 35.0 5.1 -3.8 5.9
Number of full sisters 0.6 0.8 1.8 1.3 -0.4 0.6
Suffer from ‘nerves’ 4.5 7.1 15.7 -0.9 2.2 -4.0
Overall health rating 0.6 1.3 2.0 1.4 -1.2 -0.6
Chest pain or discomfort 0.7 1.1 2.4 1.5 0.8 0.5
Had major operations 0.1 0.1 0.2 0.2 0.1 -0.5
Age at last live birth 2.1 3.0 5.1 1.7 -2.3 -1.0
Family relationship satisfaction 0.5 0.6 1.5 1.2 -0.6 -0.2
Leg pain on walking 0.4 0.4 0.7 0.8 -0.4 0.7
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.6 5.9 1.4 -1.8 2.4
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.2 -0.4 -0.4 0.3
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 4.5 -1.4 -0.7 -2.1
Medication: Aspirin 1.1 1.4 3.5 0.8 0.0 -1.9
Supplements: Vitamin C 0.1 0.2 0.4 0.2 -0.6 0.2
Knee pain experienced in last month 1.1 1.7 2.6 1.5 -1.6 -0.5
Hypertension (Self-reported) 1.2 3.2 4.5 2.1 -2.1 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.9 0.9 -0.6 0.3
Illnesses of father: Heart disease 0.3 0.4 0.6 0.8 -0.8 -0.0
Illnesses of siblings: Diabetes 0.5 0.6 1.6 0.4 -0.3 1.3
Smoking status: Previous 0.0 0.1 0.1 0.3 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 7.5 1.8 -0.6 2.7
Whole body fat-free mass 11.8 67.4 110.2 8.0 -5.3 10.5
Leg fat-free mass (right) 12.9 69.0 118.8 7.8 -5.2 10.9
Arm fat percentage (left) 7.4 29.7 42.5 4.9 -4.7 6.5
Average weekly red wine intake 0.0 0.0 0.1 -0.1 -0.3 -0.2
Handedness (chirality/laterality): Left-handed 2.7 3.3 6.5 1.6 -2.5 0.9
Mood swings 0.1 0.1 0.2 0.4 0.3 -0.2
Loneliness, isolation 1.3 1.8 2.9 1.5 -1.7 0.6
Long-standing illness, disability or infirmity 0.8 1.3 2.2 1.3 -0.2 1.5
Ever had bowel cancer screening 0.6 0.8 1.2 0.7 -0.8 -1.1
Diabetes diagnosed by doctor 0.5 0.9 1.8 0.9 0.0 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.3 0.0 -1.5 0.5
Friendships satisfaction 1.5 1.9 2.9 1.7 -1.6 -0.5
Qualifications: nursing, teaching 0.3 0.4 0.8 -0.9 -0.7 -0.1
Commuting to job workplace: Walk 0.2 0.2 0.4 -0.6 0.4 -0.3
Eye problems/disorders: Cataract 4.2 4.9 8.4 -2.9 0.3 -2.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 -0.6 0.3 -0.2
Medication for cholesterol 2.5 3.7 7.2 -2.7 1.8 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.8 0.1 -0.2 -2.0
Back pain experienced in last month 0.2 0.3 0.7 0.3 -0.8 -0.4
Mineral and other dietary supplements 0.8 1.1 3.0 -0.1 -0.6 -1.7
Breast cancer (self-reported) 0.4 0.5 0.9 -0.9 0.6 0.5
Asthma (self-reported) 3.1 6.2 15.2 1.8 0.4 3.9
Osteoporosis (self-reported) 0.5 0.7 1.7 -0.5 0.2 1.3
Osteoarthritis (self-reported) 0.0 0.1 0.1 -0.1 0.3 -0.3
Medication: Aspirin 0.7 1.0 1.7 1.1 -0.0 -1.3
Medication: Gliclazide 1.3 1.5 2.9 0.4 1.2 1.7
Illnesses of father: None of the above (group 1) 1.6 1.9 2.5 -1.1 1.4 -1.6
Smoking status: Current 0.2 0.2 0.3 -0.5 0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.7 5.8 9.9 -1.7 2.1 -3.2
Whole body water mass 11.9 68.0 112.4 8.0 -5.3 10.6
Leg predicted mass (right) 12.9 68.6 116.6 7.9 -5.2 10.8
Arm fat mass (left) 11.9 48.7 76.4 6.3 -5.5 8.7
Number of self-reported non-cancer illnesses 0.2 0.3 0.5 0.2 -0.6 -0.7
Average weekly champagne plus white wine intake 1.5 2.0 3.0 -1.6 1.7 0.7
Miserableness 0.2 0.4 0.6 0.6 0.8 0.5
Guilty feelings 4.6 6.9 13.8 3.7 -2.6 -0.0
Wears glasses or contact lenses 0.7 0.8 1.4 -0.5 0.8 1.2
Ever taken oral contraceptive pill 1.3 1.5 3.8 -0.1 0.7 2.0
Hearing aid user 0.2 0.2 0.5 0.2 -0.7 -0.0
Mother’s age at death 3.1 3.9 7.6 1.9 -2.7 -0.6
Financial situation satisfaction 0.3 0.4 1.0 0.3 -1.0 0.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 -0.1 -0.9 -1.1
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.3 0.4 0.5
Eye problems/disorders: Glaucoma 1.9 2.3 5.9 0.7 -0.7 2.4
Medication: Blood pressure 2.7 5.2 7.9 2.7 -2.8 0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.5 -0.3 -0.7 0.3
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.7 0.5 -0.1 1.6
High cholesterol (Self-reported) 1.4 2.5 7.0 0.3 -0.7 -2.6
Medication: Bendroflumethiazide 3.4 5.1 6.4 2.5 -2.5 1.7
Medication: Paracetamol 1.2 1.8 3.7 1.9 -1.2 -0.5
Medication: Lisinopril 0.4 0.5 0.6 0.8 -0.6 0.7
Medication: Atorvastatin 1.6 2.0 4.8 -1.0 2.2 -0.5
Illnesses of father: High blood pressure 2.5 3.1 6.8 -1.3 0.9 2.6
Alcohol drinker status: Never 0.8 1.0 2.3 1.5 -0.1 0.8
Ever smoked 0.2 0.3 0.9 0.2 -0.9 0.4
Basal metabolic rate 13.1 72.4 121.0 8.1 -5.5 11.0
Leg fat percentage (left) 3.7 13.4 17.1 3.1 -3.7 4.1
Arm fat-free mass (left) 11.5 58.5 95.6 7.3 -5.1 9.8
Number of operations (self-reported) 0.0 0.1 0.1 0.1 -0.2 0.4
Average weekly beer plus cider intake 1.6 2.3 3.9 -2.0 1.0 -1.5
Irritability 0.6 0.9 2.5 1.6 -0.5 -0.3
Risk taking 1.3 1.9 4.9 0.0 0.9 2.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.2 0.1 1.5 0.4
Fractured/broken bones in last 5 years 0.9 1.2 1.4 -1.2 1.2 0.9
Age started oral contraceptive pill 0.8 1.0 2.8 0.2 -1.7 -0.4
Diastolic blood pressure, automated reading 0.3 0.8 1.2 1.1 -1.1 0.2
Ever depressed for a whole week 2.0 2.5 3.3 -1.1 1.7 -1.8
Unable to work because of sickness or disability 0.1 0.1 0.1 0.0 0.4 0.3
Commuting to job workplace: Cycle 0.2 0.2 0.3 0.6 -0.4 0.5
Myopia 0.0 0.1 0.1 -0.4 0.1 0.1
Vascular/heart problems diagnosed by doctor 1.4 3.8 7.6 -2.8 1.6 -1.1
Cholesterol lowering medication 1.5 2.3 4.3 0.8 -1.4 -2.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.1 -0.4 0.6 -1.7
Pain experienced in last month 0.7 1.1 1.7 -1.3 1.2 -0.4
Supplements: Calcium 0.3 0.3 0.6 0.2 -0.8 -0.5
Basal cell carcinoma (self-reported) 0.8 1.0 1.6 -1.3 0.7 -0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.2 -0.5 0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.4 -0.0 -0.5 -1.2
Heart disease (siblings) 0.2 0.3 0.5 0.7 -0.4 -0.5
Alcohol drinker status: Previous 1.1 1.3 2.9 1.7 -0.9 -0.2
Pack years of smoking 0.6 0.9 1.3 -1.1 -0.8 -0.8
Impedance of whole body 6.8 34.7 65.8 -5.1 3.5 -8.1
Leg fat mass (left) 8.7 33.8 52.1 5.1 -4.8 7.2
Arm predicted mass (left) 11.7 59.4 98.6 7.2 -5.2 9.9