TWAS hub - CDIPT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.088	0.049	0.00540	0.040	NA	0.001	NA	0.017	3.0e-03	NA	2.8e-01	NA	3.6e-02
2	GTEx	Brain Cerebellum	0.236	0.079	0.00062	0.169	NA	0.178	NA	0.175	1.1e-05	NA	6.2e-06	NA	7.4e-06
3	GTEx	Esophagus Muscularis	0.059	0.030	0.00280	0.043	NA	0.019	NA	0.046	1.2e-03	NA	2.3e-02	NA	8.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Waist circumference	14.9	54.7	63.2	7.1	-7.1	8.0
Weight	14.2	69.8	106.1	7.9	-6.4	10.3
Basal metabolic rate	13.1	72.4	121.0	8.1	-5.5	11.0
Leg fat-free mass (right)	12.9	69.0	118.8	7.8	-5.2	10.9
Leg predicted mass (right)	12.9	68.6	116.6	7.9	-5.2	10.8
Leg predicted mass (left)	12.8	67.8	114.5	7.9	-5.2	10.7
Leg fat-free mass (left)	12.6	66.6	112.4	7.8	-5.2	10.6
Arm fat mass (right)	12.1	49.7	74.3	6.4	-5.8	8.6
Hip circumference	11.9	51.3	91.2	5.8	-5.4	9.6
Whole body water mass	11.9	68.0	112.4	8.0	-5.3	10.6
Arm fat mass (left)	11.9	48.7	76.4	6.3	-5.5	8.7
Whole body fat-free mass	11.8	67.4	110.2	8.0	-5.3	10.5
Arm predicted mass (left)	11.7	59.4	98.6	7.2	-5.2	9.9
Arm fat-free mass (left)	11.5	58.5	95.6	7.3	-5.1	9.8
Blood Red Count	10.7	103.0	289.0	-4.4	0.6	-17.0
Trunk predicted mass	10.7	61.0	98.0	7.7	-5.1	9.9
Trunk fat-free mass	10.6	61.1	97.8	7.7	-5.1	9.9
Arm predicted mass (right)	10.4	53.3	88.5	7.0	-4.8	9.4
Arm fat-free mass (right)	10.1	51.6	86.1	6.9	-4.6	9.3
Body mass index (BMI)	9.8	41.6	64.8	5.7	-5.3	8.0
BMI	9.6	55.7	82.3	6.9	-6.0	9.1
Whole body fat mass	9.6	40.2	57.0	5.7	-5.6	7.5
Number of incorrect matches in round	9.4	15.6	36.7	-2.6	1.8	-6.1
Alcohol intake frequency.	9.2	21.4	36.9	6.1	-3.9	3.5
Leg fat mass (left)	8.7	33.8	52.1	5.1	-4.8	7.2
Trunk fat mass	8.6	36.9	50.8	5.6	-5.3	7.1
Impedance of leg (right)	8.4	40.7	74.1	-5.6	4.1	-8.6
Leg fat mass (right)	8.2	31.9	49.1	5.0	-4.6	7.0
Arm fat percentage (right)	8.0	31.4	43.7	5.0	-5.0	6.6
Age when periods started (menarche)	7.9	18.9	26.5	-5.2	3.6	-4.2
Diabetes (mother)	7.8	10.0	15.2	3.9	-3.7	1.2
Impedance of leg (left)	7.8	37.7	67.1	-5.6	3.9	-8.2
Arm fat percentage (left)	7.4	29.7	42.5	4.9	-4.7	6.5
Nervous feelings	7.1	13.2	25.8	-1.8	3.2	-5.1
Impedance of whole body	6.8	34.7	65.8	-5.1	3.5	-8.1
Blood Eosinophil Count	5.3	40.9	108.2	-3.8	0.7	-10.4
Diabetes (father)	5.3	6.5	15.1	0.3	-2.1	3.9
Alcohol intake versus 10 years previously	5.1	7.7	13.7	3.7	-1.8	2.5
Body fat percentage	5.0	19.6	23.7	3.9	-4.5	4.9
Worry (Nagel 2018)	4.7	10.0	19.1	-2.0	2.6	-4.4
Comparative body size at age 10	4.7	13.1	21.5	4.6	-3.1	2.9
Guilty feelings	4.6	6.9	13.8	3.7	-2.6	-0.0
Trunk fat percentage	4.5	18.2	21.7	3.7	-4.3	4.7
Comparative height size at age 10	4.5	25.0	35.0	5.1	-3.8	5.9
Suffer from ‘nerves’	4.5	7.1	15.7	-0.9	2.2	-4.0
Impedance of arm (left)	4.3	20.1	35.4	-4.0	3.0	-6.0
Neck or shoulder pain in last month	4.2	5.9	13.0	1.8	-1.3	3.6
Eye problems/disorders: Cataract	4.2	4.9	8.4	-2.9	0.3	-2.5
Average weekly fortified wine intake	4.0	4.7	9.2	-3.0	1.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	5.4	2.3	-1.9	2.2
Leg fat percentage (left)	3.7	13.4	17.1	3.1	-3.7	4.1
Worrier / anxious feelings	3.6	6.7	11.8	-2.2	1.9	-3.4
Tense / ‘highly strung’	3.6	6.0	16.1	-0.3	1.4	-4.0
Wheeze or whistling in the chest in last year	3.6	6.4	15.0	1.9	-0.6	3.9
Alzheimer’s Disease (including proxy)	3.5	5.1	8.7	-2.0	1.6	-3.0
Relative age voice broke	3.5	5.3	9.5	-0.5	2.5	-3.1
Impedance of arm (right)	3.5	16.4	31.8	-3.6	2.2	-5.6
Hand grip strength (left)	3.4	8.8	16.7	3.1	-0.3	4.1
Serious illness, injury or assault of a close relative in last 2 years	3.4	4.0	7.0	-0.2	2.2	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.5	11.1	-0.4	1.5	-3.3
Medication: Bendroflumethiazide	3.4	5.1	6.4	2.5	-2.5	1.7
Bipolar Disorder or Schizophrenia	3.3	7.9	12.8	-1.9	2.7	-3.6
Schizophrenia (2014)	3.3	7.3	14.7	-1.4	2.3	-3.8
Alzheimer’s Disease (in mother)	3.2	3.8	7.3	-1.7	1.1	-2.7
Medication for pain relief, constipation, heartburn	3.2	5.5	10.8	-3.3	2.3	0.5
Chronotype (morning person)	3.1	7.2	11.2	3.3	-1.9	2.6
Leg fat percentage (right)	3.1	11.1	13.5	2.8	-3.4	3.7
Asthma (self-reported)	3.1	6.2	15.2	1.8	0.4	3.9
Mother’s age at death	3.1	3.9	7.6	1.9	-2.7	-0.6
Ever unenthusiastic/disinterested for a whole week	3.0	3.6	10.4	-0.4	0.6	-3.2
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	5.9	1.4	-1.8	2.4
Schizophrenia (2018)	2.9	6.1	12.1	-1.6	1.9	-3.5
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	5.7	-1.4	2.4	1.3
Asthma	2.9	5.7	14.1	1.5	0.9	3.8
Standing height	2.9	28.7	39.3	5.8	-3.6	6.3
Body Mass Index (BMI) (2010)	2.8	3.9	8.9	1.3	-1.0	3.0
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	6.6	-2.6	1.3	-1.7
Handedness (chirality/laterality): Left-handed	2.7	3.3	6.5	1.6	-2.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	9.9	-1.7	2.1	-3.2
Medication: Blood pressure	2.7	5.2	7.9	2.7	-2.8	0.6
Height	2.6	49.4	80.1	7.4	-3.7	8.9
Number of children fathered	2.6	3.0	8.3	0.8	-0.1	2.9
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	7.0	-1.1	1.8	-2.6
Medication for cholesterol	2.5	3.7	7.2	-2.7	1.8	0.9
Illnesses of father: High blood pressure	2.5	3.1	6.8	-1.3	0.9	2.6
Exposure to tobacco smoke at home	2.4	2.7	4.5	1.4	-2.1	1.3
Respiratory disease	2.3	5.1	12.3	1.4	-0.9	3.5
Angina	2.2	2.9	4.2	2.1	1.5	1.5
Hand grip strength (right)	2.1	5.7	13.1	2.0	-0.2	3.6
Number of live births	2.1	2.9	4.1	-1.7	1.3	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	7.6	-0.5	1.4	-2.7
Medication: Paracetamol	2.1	3.5	8.0	2.8	-1.6	0.0
Age at last live birth	2.1	3.0	5.1	1.7	-2.3	-1.0
Lung FEV1/FVC ratio	2.0	10.0	28.9	-1.0	0.4	-5.4
Qualifications: CSEs or equivalent	2.0	2.6	3.5	1.0	1.9	1.8
Ever depressed for a whole week	2.0	2.5	3.3	-1.1	1.7	-1.8
Blood White Count	1.9	14.1	17.7	-4.2	2.9	-4.0
Waist Hip Ratio (WHR)	1.9	8.6	14.4	3.4	-3.8	-0.5
High blood pressure (mother)	1.9	2.7	6.3	1.1	-0.7	2.5
Angina (self-reported)	1.9	2.5	2.7	1.6	1.6	1.4
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.5	-1.4	-0.7	-2.1
Eye problems/disorders: Glaucoma	1.9	2.3	5.9	0.7	-0.7	2.4
Heel T-Score	1.8	14.0	20.9	-2.3	4.0	-4.6
Mouth/teeth dental problems: Dentures	1.8	3.1	3.3	1.8	-1.7	1.8
Loud music exposure frequency	1.8	2.0	3.6	-1.5	1.9	0.4
Health satisfaction	1.8	2.3	4.3	2.1	-1.6	0.3
Lupus	1.7	2.6	7.7	-2.8	0.5	-0.2
Relative age of first facial hair	1.7	3.5	6.9	-0.2	1.9	-2.6
Ever had hysterectomy (womb removed)	1.7	1.9	4.6	-0.8	0.6	-2.1
Pain all over the body in last month	1.7	1.8	4.7	2.2	-0.0	0.8
Glaucoma (self-reported)	1.7	2.0	5.1	1.0	0.1	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	7.5	1.8	-0.6	2.7
Type 2 Diabetes (T2D) (2018)	1.6	2.9	3.3	1.8	-1.5	1.8
High blood pressure	1.6	4.4	6.3	2.5	-2.4	1.0
Forced vital capacity (FVC)	1.6	6.3	13.0	2.4	0.0	3.6
Illnesses of father: None of the above (group 1)	1.6	1.9	2.5	-1.1	1.4	-1.6
Medication: Atorvastatin	1.6	2.0	4.8	-1.0	2.2	-0.5
Average weekly beer plus cider intake	1.6	2.3	3.9	-2.0	1.0	-1.5
Pulse rate	1.5	2.5	5.0	-2.2	0.9	-1.4
Medication: Ibuprofen	1.5	1.8	2.7	1.3	-1.1	1.6
Friendships satisfaction	1.5	1.9	2.9	1.7	-1.6	-0.5
Average weekly champagne plus white wine intake	1.5	2.0	3.0	-1.6	1.7	0.7
Cholesterol lowering medication	1.5	2.3	4.3	0.8	-1.4	-2.1
Medication: Co-codamol	1.4	1.6	3.1	1.8	-1.1	0.8
Hayfever, allergic rhinitis or eczema	1.4	3.0	5.2	-2.3	0.9	1.8
Medication: Ramipril	1.4	1.7	2.6	1.1	-1.6	1.2
High cholesterol (Self-reported)	1.4	2.5	7.0	0.3	-0.7	-2.6
Vascular/heart problems diagnosed by doctor	1.4	3.8	7.6	-2.8	1.6	-1.1
LDL Cholesterol	1.3	2.1	4.2	-1.4	-0.2	-2.1
Mouth/teeth dental problems	1.3	2.0	3.0	-1.7	0.9	-1.4
Medication: Simvastatin	1.3	1.8	5.2	-0.4	-0.4	-2.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.9	-0.5	1.7	-1.2
Qualifications: College or University degree	1.3	4.0	7.2	-2.7	1.7	-1.4
Loneliness, isolation	1.3	1.8	2.9	1.5	-1.7	0.6
Medication: Gliclazide	1.3	1.5	2.9	0.4	1.2	1.7
Ever taken oral contraceptive pill	1.3	1.5	3.8	-0.1	0.7	2.0
Risk taking	1.3	1.9	4.9	0.0	0.9	2.2
Allergy or Eczema	1.2	3.1	7.3	-2.7	1.3	0.5
Maternal smoking around birth	1.2	1.7	3.8	-1.1	2.0	0.2
Serious illness, injury or assault to yourself	1.2	1.5	2.3	1.5	-0.8	1.2
Multivitamins +/- minerals	1.2	1.6	3.6	0.9	0.5	1.9
Alcohol usually taken with meals	1.2	1.9	3.3	0.6	-1.4	1.8
Had menopause	1.2	1.4	3.9	0.4	-2.0	-0.5
Prospective memory result	1.2	1.5	2.8	0.6	-1.7	-1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.3	1.1	-0.8	1.5
Shortness of breath walking on level ground	1.2	1.4	3.1	1.0	-1.8	0.2
Hypertension (Self-reported)	1.2	3.2	4.5	2.1	-2.1	0.9
Medication: Paracetamol	1.2	1.8	3.7	1.9	-1.2	-0.5
Bipolar Disorder (2018)	1.1	1.7	3.5	-1.1	1.9	-0.7
Prostate Cancer	1.1	1.6	2.6	1.0	-1.1	-1.6
Depression (self-reported)	1.1	1.3	3.5	0.7	-0.2	-1.9
Forced vital capacity (FVC), Best measure	1.1	4.1	8.5	1.8	0.9	2.9
Medication: Aspirin	1.1	1.4	3.5	0.8	0.0	-1.9
Knee pain experienced in last month	1.1	1.7	2.6	1.5	-1.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.8	0.1	-0.2	-2.0
Alcohol drinker status: Previous	1.1	1.3	2.9	1.7	-0.9	-0.2
Average weekly spirits intake	1.0	1.2	2.7	-1.6	1.0	-0.1
Supplements: Glucosamine	1.0	1.2	3.3	-0.6	0.2	1.8
Eye problems/disorders: None of the above	1.0	1.2	1.6	0.9	1.2	-1.1
Mean time to correctly identify matches	1.0	1.9	2.9	-0.6	-1.6	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.1	-0.4	0.6	-1.7
Neuroticism (Nagel 2018)	0.9	2.1	4.1	-0.5	1.4	-2.0
Fasting Glucose	0.9	1.1	1.6	-0.7	1.1	-1.3
Sensitivity / hurt feelings	0.9	1.5	2.7	-1.1	0.8	-1.6
Medication for hormone replacement therapy	0.9	1.0	1.5	0.8	1.2	-1.0
Allergy	0.9	2.1	3.7	1.0	-1.2	-1.9
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	4.5	2.0	-0.5	2.1
Lung cancer (father)	0.9	1.0	1.7	1.3	-1.1	-0.2
Migraine (self-reported)	0.9	1.2	2.0	-1.4	-0.2	-1.2
Fractured/broken bones in last 5 years	0.9	1.2	1.4	-1.2	1.2	0.9
HDL Cholesterol	0.8	1.3	1.6	-1.3	1.1	-1.0
Rheumatoid Arthritis	0.8	1.2	3.2	1.8	-0.5	0.2
Cardiovascular Disease	0.8	2.8	5.2	1.7	-2.3	0.3
Medication: Metformin	0.8	1.2	2.8	0.8	0.1	1.7
Fed-up feelings	0.8	1.5	2.3	1.3	0.5	1.5
Medication: Levothyroxine sodium	0.8	1.4	2.8	1.0	-1.7	0.4
Financial difficulties in last 2 years	0.8	1.1	1.7	1.1	0.6	1.3
Illnesses of siblings	0.8	1.1	2.7	-0.7	1.6	0.1
Medication: Cholesterol lowering	0.8	1.2	2.4	-0.1	1.1	-1.5
Medication: Blood pressure	0.8	1.3	2.9	1.7	-0.7	0.8
Long-standing illness, disability or infirmity	0.8	1.3	2.2	1.3	-0.2	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	0.0	-1.5	0.5
Mineral and other dietary supplements	0.8	1.1	3.0	-0.1	-0.6	-1.7
Alcohol drinker status: Never	0.8	1.0	2.3	1.5	-0.1	0.8
Age started oral contraceptive pill	0.8	1.0	2.8	0.2	-1.7	-0.4
Basal cell carcinoma (self-reported)	0.8	1.0	1.6	-1.3	0.7	-0.9
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.9	1.7	-1.4	1.3
Sitting height	0.7	5.3	10.2	3.2	-1.6	1.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	1.1	-0.6	-0.8
Chest pain or discomfort	0.7	1.1	2.4	1.5	0.8	0.5
Medication: Aspirin	0.7	1.0	1.7	1.1	-0.0	-1.3
Wears glasses or contact lenses	0.7	0.8	1.4	-0.5	0.8	1.2
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.7	0.5	-0.1	1.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	0.1	1.5	0.4
Pain experienced in last month	0.7	1.1	1.7	-1.3	1.2	-0.4
Crohns Disease (2012)	0.6	1.0	1.8	0.1	1.1	-1.3
Blood Platelet Count	0.6	7.1	9.9	-1.8	-2.9	-3.1
Systolic Blood Pressure	0.6	2.9	5.3	2.3	-1.1	1.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-0.8	1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.3	0.1	1.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.8	-0.7	2.0	-0.0
Neuroticism score	0.6	1.2	2.3	1.0	0.5	-1.5
Time employed in main current job	0.6	0.7	2.1	0.3	0.1	-1.5
Falls in the last year	0.6	0.8	2.0	-0.3	0.5	1.4
Illnesses of mother	0.6	0.7	1.7	-0.4	0.4	-1.3
Peak expiratory flow (PEF)	0.6	1.5	2.4	1.6	-0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.7	1.2	-0.4
Pulse wave peak to peak time	0.6	0.7	0.9	-0.6	0.8	0.9
Number of full sisters	0.6	0.8	1.8	1.3	-0.4	0.6
Overall health rating	0.6	1.3	2.0	1.4	-1.2	-0.6
Ever had bowel cancer screening	0.6	0.8	1.2	0.7	-0.8	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.1	-0.9	-1.1
Irritability	0.6	0.9	2.5	1.6	-0.5	-0.3
Pack years of smoking	0.6	0.9	1.3	-1.1	-0.8	-0.8
Depression (Nagel 2018)	0.5	0.8	2.1	-0.5	0.0	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	0.3	-1.0	-1.1
Major Depression (MDD)	0.5	0.6	1.9	0.0	0.0	-1.4
Neuroticism (2016)	0.5	0.8	1.6	0.9	-0.2	-1.2
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.5	0.1	1.4
Supplements: Zinc	0.5	0.6	1.1	0.3	-0.7	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	0.8	-1.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.1	-0.1	-1.3
Hearing difficulty/problems with background noise	0.5	0.8	1.3	0.8	-0.6	-1.1
Diabetes (self-reported)	0.5	0.7	1.1	1.0	-0.2	1.1
Fluid intelligence score	0.5	1.1	2.8	-0.7	0.3	1.7
Hair/balding pattern: Pattern 3	0.5	0.8	0.9	-0.9	0.8	-0.9
Happiness	0.5	0.6	1.0	-0.9	0.1	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	0.8	0.8	-0.9	-0.5
Birth weight of first child	0.5	0.9	2.0	0.8	-0.1	1.4
Pulse wave reflection index	0.5	0.6	1.2	1.1	-0.8	0.4
Birth weight	0.5	1.1	2.0	1.0	0.5	1.4
High blood pressure (siblings)	0.5	0.7	1.3	1.1	-0.8	-0.3
Age at first live birth	0.5	0.9	1.9	0.2	-1.4	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	-0.3	-0.3	1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.0	1.0	-0.7	0.5
Family relationship satisfaction	0.5	0.6	1.5	1.2	-0.6	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.6	0.4	-0.3	1.3
Diabetes diagnosed by doctor	0.5	0.9	1.8	0.9	0.0	1.3
Osteoporosis (self-reported)	0.5	0.7	1.7	-0.5	0.2	1.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.2	0.8	-1.1	0.9
Age at First Birth	0.4	0.6	1.1	1.0	-0.8	0.2
Neuroticism	0.4	1.0	2.3	0.6	0.6	-1.5
Number of treatments/medications taken	0.4	0.8	2.3	1.5	0.0	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.6	0.3	-1.2
Vitamin and mineral supplements	0.4	0.5	1.5	-0.2	-0.1	-1.2
Severe depression (siblings)	0.4	0.5	0.7	0.8	-0.8	-0.1
Pack years adult smoking proportion	0.4	0.6	0.9	-1.0	-0.6	-0.6
Townsend deprivation index at recruitment	0.4	0.6	1.5	1.2	-0.6	0.1
Length of working week for main job	0.4	0.4	0.8	0.5	-0.9	0.4
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.4	-0.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.0	0.2	1.2
Leg pain on walking	0.4	0.4	0.7	0.8	-0.4	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	0.9	-0.6	0.3
Breast cancer (self-reported)	0.4	0.5	0.9	-0.9	0.6	0.5
Medication: Lisinopril	0.4	0.5	0.6	0.8	-0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.0	-0.5	-1.2
Reaction Time	0.3	0.6	1.4	0.0	-1.2	-0.6
Breast Cancer	0.3	0.6	1.6	1.3	0.4	-0.3
HbA1C	0.3	0.4	1.0	-0.3	0.2	1.0
Lung FVC	0.3	1.5	2.9	-1.1	1.7	-0.6
Tanning	0.3	3.4	3.7	-1.7	1.9	-1.9
Qualifications: None of the above	0.3	0.6	1.2	0.6	-0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.7	0.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	-0.7	-0.1	-1.2
Breastfed as a baby	0.3	0.4	1.2	-0.2	-0.2	1.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.3	1.2	-0.9	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.4	0.6	0.8
Headache pain in last month	0.3	0.5	0.9	1.0	-0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.6	-0.3	1.0
Gout (self-reported)	0.3	0.4	1.0	-0.4	1.0	0.1
Medication: Amlodipine	0.3	0.4	1.2	1.1	0.2	0.0
Exposure to tobacco smoke outside home	0.3	0.3	0.8	-0.3	0.9	-0.4
Worry too long after embarrassment	0.3	0.5	1.1	-0.4	0.6	-1.1
Medication: Allopurinol	0.3	0.4	1.3	0.2	1.1	0.0
Illnesses of father: Heart disease	0.3	0.4	0.6	0.8	-0.8	-0.0
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.9	-0.7	-0.1
Financial situation satisfaction	0.3	0.4	1.0	0.3	-1.0	0.3
Diastolic blood pressure, automated reading	0.3	0.8	1.2	1.1	-1.1	0.2
Supplements: Calcium	0.3	0.3	0.6	0.2	-0.8	-0.5
Alzheimer’s Disease (in father)	0.2	0.3	0.5	0.4	0.7	-0.3
Crohns Disease (2017)	0.2	0.4	0.8	0.3	0.7	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.2	0.1	-1.1
Smoking Status	0.2	0.4	0.7	-0.4	0.8	0.7
Systolic blood pressure, automated reading	0.2	0.6	1.2	1.1	-0.9	0.2
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.3	0.1	-0.8
Medication: Atenolol	0.2	0.2	0.4	0.6	-0.4	0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.5	0.9	-0.0
Had other major operations	0.2	0.2	0.5	0.4	-0.1	0.7
Medication: Lansoprazole	0.2	0.2	0.6	0.3	0.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	0.9	0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.5	-0.8	-0.0
Number of full brothers	0.2	0.3	0.8	0.9	-0.1	0.3
Emphysema/chronic bronchitis	0.2	0.3	0.4	-0.6	-0.5	-0.4
Medication: Omeprazole	0.2	0.3	0.8	0.1	0.2	-0.9
Heart disease (mother)	0.2	0.3	0.7	0.5	0.0	0.8
Pulse rate, automated reading	0.2	0.6	1.4	-1.2	-0.5	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	0.4	-0.3
Back pain experienced in last month	0.2	0.3	0.7	0.3	-0.8	-0.4
Smoking status: Current	0.2	0.2	0.3	-0.5	0.5	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.2	-0.6	-0.7
Miserableness	0.2	0.4	0.6	0.6	0.8	0.5
Hearing aid user	0.2	0.2	0.5	0.2	-0.7	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.3	-0.7	0.3
Ever smoked	0.2	0.3	0.9	0.2	-0.9	0.4
Commuting to job workplace: Cycle	0.2	0.2	0.3	0.6	-0.4	0.5
Heart disease (siblings)	0.2	0.3	0.5	0.7	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.5	0.5	-0.0
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.3	-0.5	-0.5
Ovarian Cancer	0.1	0.1	0.2	-0.0	0.4	-0.3
Mean Putamen Volume	0.1	0.1	0.1	0.4	-0.2	-0.0
Triglycerides	0.1	0.1	0.2	0.4	0.1	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.5	-0.7	0.0
Taking other prescription medications	0.1	0.2	0.4	0.6	-0.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.6	-0.3	-0.3
Father’s age at death	0.1	0.2	0.4	0.2	0.0	-0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.6	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.4	-0.2	-0.2
Had major operations	0.1	0.1	0.2	0.2	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	-0.4	-0.4	0.3
Supplements: Vitamin C	0.1	0.2	0.4	0.2	-0.6	0.2
Mood swings	0.1	0.1	0.2	0.4	0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.6	0.3	-0.2
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.3	0.4	0.5
Unable to work because of sickness or disability	0.1	0.1	0.1	0.0	0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.2	-0.5	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.3	-0.1	0.2
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.1	0.4	-0.2
Hair Pigment	0.0	0.2	0.5	-0.7	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	0.2	-0.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.0	-0.1	0.2
Current tobacco smoking	0.0	0.1	0.1	-0.1	0.3	0.3
Past tobacco smoking	0.0	0.0	0.1	-0.2	0.3	0.0
Heart attack	0.0	0.1	0.1	0.2	-0.4	0.1
Noisy workplace	0.0	0.0	0.1	-0.3	0.1	0.0
Smoking status: Previous	0.0	0.1	0.1	0.3	-0.2	-0.2
Average weekly red wine intake	0.0	0.0	0.1	-0.1	-0.3	-0.2
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.1	0.3	-0.3
Number of operations (self-reported)	0.0	0.1	0.1	0.1	-0.2	0.4
Myopia	0.0	0.1	0.1	-0.4	0.1	0.1

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