Hub : Genes

AP1B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0600	0.0250	3.9e-03	0.051	NA	0.049	NA	0.054	2.6e-04	NA	0.00033	NA	0.00018
2	GTEx	Skin Sun Exposed Lower leg	0.0570	0.0250	4.9e-03	0.039	NA	0.029	NA	0.030	3.3e-04	NA	0.00160	NA	0.00140
3	GTEx	Testis	0.1770	0.0650	9.2e-04	0.133	NA	0.096	NA	0.059	1.8e-06	NA	0.00005	NA	0.00130
4	METSIM	Adipose	0.0498	0.0173	9.7e-05	0.013	0.024	0.019	0.024	0.016	4.3e-03	0.00012	0.00056	0.00015	0.00160
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0450	0.0232	5.2e-04	0.022	0.026	0.027	NA	0.023	1.5e-03	0.00055	0.00049	NA	0.00110
6	TCGA	Lung Squamous Cell Carcinoma	0.0659	0.0363	3.3e-03	0.004	0.005	0.008	NA	0.003	9.1e-02	0.07800	0.03900	NA	0.14000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.4	2.2	5.0	1.5	1.1	-2.2	0.4	-2.0	-0.9
Bipolar Disorder or Schizophrenia	1.2	3.0	5.9	2.1	1.0	-2.4	0.4	-2.4	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-0.6	-0.5	0.7	0.2	1.0	-1.3
Depression (Nagel 2018)	0.6	0.9	2.2	1.2	1.0	-1.5	-0.7	-0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.3	0.1	2.1	-0.4	-1.0	-0.4	1.4
Neuroticism (Nagel 2018)	0.9	2.2	2.8	1.6	1.7	-1.5	-1.7	-1.5	-0.8
Schizophrenia (2018)	0.5	1.0	2.4	1.5	0.4	-1.2	0.1	-1.5	-0.1
Schizophrenia vs Biploar Disorder	1.9	2.5	6.7	-1.7	-0.7	2.0	0.2	2.6	0.9
Worry (Nagel 2018)	3.1	6.5	9.7	2.9	2.8	-3.1	-2.5	-2.5	0.8
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.9	0.9	0.7	-0.2	0.5	0.8
Alzheimer’s Disease (in father)	0.5	0.5	0.9	-0.4	-0.0	0.8	0.8	0.8	1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.4	0.8	0.5	-0.1	0.6	1.3
Crohns Disease (2017)	0.8	1.8	7.7	-0.6	-1.3	0.8	-0.1	0.3	-2.8
Irritable Bowel Disease (IBD)	1.3	3.0	10.8	-1.1	-1.8	1.4	0.4	0.8	-3.3
Ulcerative Colitis (UC)	1.7	3.1	6.7	-1.2	-2.4	1.7	0.9	1.2	-2.6
Major Depression (MDD)	0.4	0.5	1.8	0.4	0.9	-0.3	-1.3	-0.0	-0.5
Reaction Time	1.0	1.9	4.1	2.0	0.4	-1.2	-1.5	-1.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.9	0.9	0.5	-0.5	0.1	0.4
Breast Cancer	1.6	3.9	10.8	-0.8	-3.2	1.0	3.3	-0.4	-0.3
Ovarian Cancer	0.7	0.9	2.2	1.0	0.5	-1.5	-0.9	-1.2	-0.3
Prostate Cancer	0.2	0.2	0.8	0.0	0.9	0.1	-0.6	0.3	-0.2
Age at First Birth	0.9	1.3	2.8	1.4	0.4	-0.9	-0.0	-1.5	1.7
Bipolar Disorder (2011)	1.0	1.0	2.3	1.5	0.3	-1.4	-0.5	-1.0	-0.5
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	-0.9	-1.4	0.7	0.8	0.3	-1.1
Coronary Artery Disease (CAD)	0.3	0.4	1.0	-0.5	0.7	-0.2	1.0	0.1	-0.7
Crohns Disease (2012)	0.6	1.0	2.2	-1.0	-0.5	1.1	-0.3	1.2	-1.5
Mean Putamen Volume	1.3	1.5	3.7	1.6	0.6	-1.0	-1.9	-1.0	-0.3
Fasting Glucose	0.3	0.3	0.9	0.7	-0.2	-0.4	0.2	-0.5	-0.9
HbA1C	0.6	0.7	2.7	0.2	0.4	-0.2	-1.0	-1.6	-0.2
HDL Cholesterol	0.8	1.4	3.0	-1.3	-0.2	1.4	1.7	1.0	0.8
LDL Cholesterol	1.1	1.7	4.0	1.4	-0.2	-1.1	-1.3	-2.0	-1.2
Lupus	0.2	0.3	0.8	-0.2	0.1	0.2	0.6	0.4	0.9
Neuroticism (2016)	1.5	2.1	3.4	1.2	0.7	-1.4	-1.8	-1.6	-1.6
Primary Biliary Cirrhosis	0.5	0.7	1.4	-0.9	0.9	1.1	0.1	1.2	-0.0
Rheumatoid Arthritis	0.3	0.3	1.0	-0.2	1.0	-0.3	-0.7	-0.3	-0.6
Schizophrenia (2014)	0.7	1.5	3.2	1.8	1.0	-1.7	0.0	-1.4	0.4
Triglycerides	0.6	1.0	3.3	1.1	0.4	-0.7	-1.8	-0.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.1	0.8	0.6	-1.4	-0.8	-0.8	-1.4
Ulcerative Colitis	0.5	0.8	2.7	-0.8	-0.9	0.4	0.3	0.5	-1.6
Blood Eosinophil Count	0.2	1.8	4.5	1.8	0.9	-0.4	-2.1	-0.9	1.3
Blood Platelet Count	1.1	12.7	31.8	4.1	-1.7	-3.5	-1.9	-5.6	-3.0
Blood Red Count	0.3	3.2	8.0	1.4	0.7	-2.0	-2.8	-1.4	-1.7
Blood White Count	1.2	8.9	13.9	3.6	0.2	-2.2	-3.3	-3.3	-3.7
Heel T-Score	3.5	28.1	48.9	-7.0	-3.6	6.4	4.6	6.7	0.2
BMI	0.3	1.6	5.8	-0.2	-2.4	0.7	0.9	0.4	-1.4
Height	0.2	4.3	7.9	-2.3	-0.7	2.6	2.2	2.8	0.7
Waist Hip Ratio (WHR)	1.1	4.9	9.5	1.8	1.3	-1.2	-2.3	-2.8	-3.1
Systolic Blood Pressure	0.2	0.9	2.3	1.0	1.5	-0.6	-0.9	-0.9	0.7
Smoking Status	0.7	1.8	3.5	-1.0	-0.7	1.5	1.9	1.0	-1.5
Allergy or Eczema	0.2	0.5	1.1	-0.7	-0.6	1.1	0.4	-0.2	-0.8
Cardiovascular Disease	0.3	1.0	1.9	-0.9	-0.8	1.4	0.9	1.2	-0.7
Hypothyroidism (self reported)	0.6	1.5	2.6	0.6	0.4	-1.4	-1.6	-1.2	-1.6
Respiratory disease	2.6	5.8	8.5	2.8	2.1	-2.7	-2.9	-2.4	-0.6
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.8	-0.6	-2.2	1.2	0.8	0.9	-1.9
Lung FEV1/FVC ratio	3.7	18.7	39.1	-6.2	0.2	4.0	3.8	4.9	4.4
Lung FVC	0.6	3.2	5.7	-0.6	-1.1	1.6	2.3	2.0	2.4
Neuroticism	1.5	3.5	5.5	1.7	2.3	-2.2	-1.9	-1.8	-0.9
Chronotype (morning person)	2.3	5.4	8.6	2.7	1.1	-2.6	-2.8	-2.9	-0.2
Hair Pigment	0.2	4.5	7.0	2.0	2.6	-2.0	-2.0	-2.2	-1.7
Tanning	0.1	1.0	2.9	1.7	-0.7	-0.3	-0.2	-0.5	1.4
Hand grip strength (left)	0.1	0.4	1.0	0.5	0.6	0.4	-0.2	1.0	0.5
Number of treatments/medications taken	0.1	0.1	0.5	0.3	-0.3	0.7	-0.0	-0.1	-0.3
Average weekly spirits intake	1.0	1.3	4.9	0.7	-1.2	0.6	-0.8	-0.1	-2.2
Sensitivity / hurt feelings	2.0	3.5	8.9	2.2	0.5	-1.8	-1.0	-3.0	-1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	0.7	0.5	-0.9	-0.8	-0.5	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.4	-0.1	0.8	-0.9	1.3	0.4
Relative age of first facial hair	0.3	0.5	2.0	0.7	1.4	-0.8	-0.1	0.1	0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	6.8	-1.2	-0.9	1.4	1.2	0.2	-2.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.3	-0.6	-0.2	0.2	1.1	0.4	-0.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.8	-0.4	-0.4	0.1	-0.5	1.3	-0.1
Systolic blood pressure, automated reading	1.1	3.3	5.4	2.3	1.6	-2.1	-1.7	-2.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.5	0.4	-1.2	0.3	0.5	-0.2	-1.2
Angina	0.4	0.5	1.1	-1.0	0.3	0.4	-0.6	0.8	-0.9
Medication for hormone replacement therapy	0.2	0.3	0.8	0.9	-0.2	0.1	0.1	-0.7	-0.5
Vitamin and mineral supplements	2.0	2.7	7.4	0.9	-0.8	-0.9	-1.4	-2.1	-2.7
Supplements: Zinc	1.1	1.2	2.6	-1.6	-0.1	1.1	1.0	1.6	0.3
Medication: Co-codamol	0.9	1.0	2.3	-0.9	-0.4	1.5	0.7	1.5	0.3
Medication: Metformin	1.7	2.4	10.5	0.2	-1.8	0.4	0.3	0.8	-3.2
Diabetes (father)	1.1	1.4	3.9	1.3	0.0	-0.8	-0.8	-2.0	-1.1
Diabetes (mother)	1.0	1.3	3.2	1.3	-0.6	-0.1	-0.6	-1.4	-1.8
Severe depression (siblings)	0.3	0.3	0.8	-0.6	-0.9	0.6	0.3	0.1	-0.7
Pack years adult smoking proportion	3.1	4.7	11.3	2.7	1.9	-1.9	-3.4	-1.3	-0.7
Impedance of leg (right)	0.8	4.0	9.6	-3.1	1.0	1.5	1.4	2.8	1.1
Leg fat-free mass (left)	0.3	1.5	4.6	-0.3	-2.1	1.2	0.6	0.3	-1.5
Trunk fat percentage	0.9	3.4	5.2	-2.2	-2.3	2.1	1.7	1.9	-0.4
Hand grip strength (right)	0.4	1.1	3.2	1.8	1.1	-0.9	-0.9	-0.4	0.4
Townsend deprivation index at recruitment	0.4	0.5	1.3	0.8	-1.1	0.1	0.3	0.2	-1.1
Current tobacco smoking	0.5	0.8	1.7	-0.2	-0.9	0.7	1.3	0.6	-1.2
Average weekly fortified wine intake	0.7	0.8	2.2	0.3	-1.3	0.2	0.4	-1.0	-1.5
Maternal smoking around birth	0.8	1.2	2.3	-1.2	-0.7	0.9	1.4	1.5	-0.3
Fed-up feelings	0.3	0.6	1.3	-0.9	-0.5	0.8	0.1	1.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.1	1.1	1.1	-1.4	-1.4	-1.0	-0.5
Relative age voice broke	0.4	0.7	1.1	1.1	0.7	-0.9	-0.1	-0.8	-1.1
Taking other prescription medications	0.2	0.3	0.6	0.3	-0.8	0.6	-0.1	0.2	-0.8
Age when periods started (menarche)	0.2	0.5	2.6	0.5	0.4	0.2	0.0	0.3	1.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.9	2.0	1.6	-2.2	-1.3	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	6.6	-2.6	-1.1	2.6	0.4	2.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.8	-0.5	-0.8	-0.2	-0.9	-0.4	-1.9
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	-0.6	0.2	0.0	0.4	-0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.9	-0.1	-0.5	0.3	0.1	-0.2	-0.9
High blood pressure	0.2	0.6	2.6	0.2	-0.0	0.1	0.6	-0.7	-1.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	-1.1	-0.5	1.3	0.6	-0.1	-1.1
Multivitamins +/- minerals	2.9	3.7	6.4	-2.0	0.6	1.8	1.5	2.5	2.4
Stomach or abdominal pain in last month	1.2	1.5	2.9	1.1	0.3	-1.4	-1.1	-1.7	-1.3
Supplements: Glucosamine	0.4	0.5	2.0	-1.4	0.5	0.6	0.5	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.5	0.6	1.9	-0.3	-0.8	0.1	0.4
Medication: Atenolol	0.7	0.9	2.1	-0.9	-0.6	0.5	1.0	1.5	-0.9
Medication: Levothyroxine sodium	0.9	1.5	4.8	0.2	-0.8	-0.8	-0.8	-1.5	-2.2
Sitting height	0.8	5.5	11.3	-2.8	-1.1	3.3	0.4	3.4	1.1
Chronic bronchitis/emphysema (father)	1.0	1.1	3.2	0.7	-0.8	-0.5	-1.4	-0.6	-1.8
High blood pressure (mother)	0.2	0.2	1.0	-0.5	0.2	0.1	1.0	0.2	0.3
Body mass index (BMI)	0.1	0.5	2.7	0.2	-1.6	0.2	-0.1	0.1	-0.6
Impedance of leg (left)	0.5	2.3	6.3	-2.5	1.0	1.2	1.0	1.9	0.6
Leg predicted mass (left)	0.3	1.4	4.3	-0.3	-2.1	1.2	0.6	0.3	-1.5
Trunk fat mass	0.7	2.9	6.1	-1.7	-2.5	1.9	1.4	1.4	-0.8
Waist circumference	0.3	1.0	3.3	0.1	-1.5	0.4	-0.3	-0.3	-1.8
Number of incorrect matches in round	1.5	2.5	5.6	0.2	-1.4	-1.0	1.7	-1.9	-2.4
Past tobacco smoking	0.2	0.4	0.9	0.6	-1.0	-0.5	0.2	-0.3	0.9
Alcohol usually taken with meals	0.2	0.3	0.9	-0.6	-0.1	0.3	0.9	-0.5	0.5
Nervous feelings	3.0	5.6	9.2	2.9	2.2	-3.0	-1.8	-2.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.7	-0.1	1.3	-0.7	-0.1	-0.2	0.3
Hearing difficulty/problems with background noise	0.7	1.1	2.2	1.4	0.4	-0.6	-1.5	-0.8	-1.2
Hair/balding pattern: Pattern 2	1.3	1.7	4.7	-0.1	2.2	-1.2	-1.7	0.1	0.9
Had menopause	0.3	0.3	0.6	0.8	-0.8	-0.1	0.5	-0.3	-0.6
Had other major operations	1.8	2.2	4.6	-2.1	-1.1	1.1	2.2	1.2	-0.5
Forced vital capacity (FVC)	1.1	4.3	7.1	-2.5	-0.9	2.7	2.3	2.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	8.3	-2.9	-1.6	2.9	1.5	2.1	-0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	5.5	-0.7	-0.9	1.7	-0.2	0.3	-2.3
Qualifications: None of the above	0.8	1.7	3.3	-0.5	-1.6	0.7	1.5	1.2	1.8
Financial difficulties in last 2 years	1.0	1.4	1.9	-1.2	-1.4	1.4	1.4	0.4	-1.1
Mouth/teeth dental problems	0.4	0.7	2.1	-0.5	0.7	0.1	0.9	-0.5	1.5
Heart attack	0.8	1.0	2.5	0.3	1.6	-1.2	-1.3	-0.5	-0.1
Allergy	0.5	1.1	4.6	-0.1	-0.2	-0.2	0.9	1.1	2.1
Pain all over the body in last month	2.0	2.1	4.1	-1.8	-2.0	1.4	0.9	1.4	-0.7
Diabetes (self-reported)	0.7	1.1	3.6	0.4	-1.6	0.2	-0.3	0.1	-1.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.5	-0.7	1.1	-0.5	0.7	0.2
Medication: Ramipril	1.1	1.4	2.5	-1.2	-1.0	1.4	1.6	1.2	-0.2
Medication: Simvastatin	1.6	2.4	4.7	2.2	1.7	-1.7	-1.8	-0.5	0.6
Fluid intelligence score	0.2	0.5	1.1	-0.1	1.0	-0.4	-0.9	-0.8	0.5
Illnesses of siblings	0.6	0.8	4.1	-0.1	0.6	0.2	0.4	0.2	2.0
Neuroticism score	1.2	2.5	3.2	1.2	1.8	-1.7	-1.6	-1.8	-1.4
Weight	0.3	1.5	3.8	-0.9	-1.9	1.4	0.7	1.0	-1.1
Impedance of arm (right)	0.7	3.2	7.4	-2.7	0.7	1.7	1.0	2.5	1.0
Arm fat percentage (right)	0.2	0.6	1.1	-0.9	-1.1	0.7	-0.1	1.0	-0.5
Trunk fat-free mass	0.1	0.4	1.3	0.1	-0.8	0.4	-0.1	-0.2	-1.1
Hip circumference	0.4	1.6	3.2	-1.5	-1.8	1.2	0.8	1.5	0.1
Time employed in main current job	1.2	1.3	3.7	-0.1	-1.9	0.3	1.4	0.0	-1.5
Alcohol intake versus 10 years previously	0.4	0.6	1.9	1.1	-0.0	-1.4	-0.3	-0.3	0.3
Father’s age at death	0.5	0.6	1.7	0.5	-0.1	-0.8	0.4	-1.3	-1.0
Worrier / anxious feelings	1.2	2.3	3.2	1.1	1.3	-1.8	-1.5	-1.7	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.1	1.4	0.5	-1.0	-1.2	-1.8	-2.0
Falls in the last year	0.5	0.7	2.8	0.2	-0.0	0.2	-1.0	-0.4	-1.7
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-0.2	-1.3	0.7	1.3	0.9	-0.1
Number of live births	0.7	1.0	2.3	-1.5	-1.0	-0.1	1.2	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	14.8	-3.8	-0.1	3.2	2.8	3.4	2.0
Pulse rate	1.5	2.5	5.5	2.4	-0.1	-1.8	-1.1	-2.2	-0.5
Happiness	2.0	2.5	3.8	1.5	1.7	-2.0	-1.4	-1.5	-1.2
Noisy workplace	0.2	0.3	0.6	0.8	-0.6	0.3	-0.5	0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.7	1.3	1.8	-0.9	-0.8	-1.9	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.5	-2.1	0.1	1.6	1.0	1.1	-0.4
Mouth/teeth dental problems: Dentures	1.4	2.3	4.2	-0.8	-2.0	1.9	0.1	2.0	-1.3
Asthma	2.9	5.7	9.7	2.9	2.0	-2.5	-3.1	-2.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	-0.9	-0.9	1.1	0.1	0.5	-1.3
Medication: Cholesterol lowering	0.4	0.6	1.8	0.1	1.1	-0.6	-1.3	0.3	0.6
Depression (self-reported)	0.3	0.4	0.8	-0.8	0.3	0.4	0.4	0.9	-0.6
Medication: Lansoprazole	1.1	1.3	3.0	-1.0	-1.1	0.9	1.2	0.6	-1.7
Prospective memory result	1.2	1.5	7.9	0.9	-0.0	-0.1	0.5	-0.1	2.8
Lung cancer (father)	0.6	0.7	1.5	1.1	1.2	-0.7	0.1	-0.4	1.1
Illnesses of mother	0.8	1.0	2.0	-1.3	-1.2	0.7	1.4	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.0	21.2	-4.6	-0.3	4.0	2.6	4.0	2.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	-0.9	-0.9	0.7	1.0	0.5	-0.5
Impedance of arm (left)	0.6	2.7	7.1	-2.7	0.3	1.8	1.3	1.9	0.7
Arm fat mass (right)	0.2	0.7	2.0	-0.6	-1.4	0.7	-0.1	0.7	-1.1
Trunk predicted mass	0.1	0.4	1.2	0.2	-0.9	0.4	-0.1	-0.2	-1.1
Standing height	0.4	3.7	7.6	-2.6	-0.9	2.8	1.6	1.9	-0.9
Length of working week for main job	0.2	0.2	0.8	0.0	0.1	0.2	-0.0	-0.6	-0.9
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.0	0.1	0.3	0.7	0.1	0.8
Breastfed as a baby	1.2	1.5	5.2	1.0	0.1	-1.1	-0.2	-2.3	-1.1
Tense / ‘highly strung’	3.0	4.9	7.2	1.9	2.7	-2.5	-2.4	-2.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.1	0.4	0.5	0.6	0.0	-0.3
Hair/balding pattern: Pattern 4	3.0	7.3	17.3	-1.6	-3.6	2.8	4.2	0.5	-1.6
Birth weight of first child	1.2	2.1	3.2	1.8	1.7	-1.5	-1.3	-1.6	-0.2
Peak expiratory flow (PEF)	1.3	2.9	5.7	-2.4	1.8	1.2	0.8	2.0	1.6
Pulse wave reflection index	0.9	1.1	1.9	-1.2	-0.6	1.4	1.1	1.3	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.4	-0.6	1.5	0.4	-0.6	0.1	0.1
Loud music exposure frequency	0.3	0.4	1.2	0.3	-0.5	0.2	1.1	-0.1	-0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.7	-0.9	-0.6	1.3	-0.0	0.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.9	0.4	-0.9	-0.7	-0.3	-0.9
Blood clot in the leg (DVT)	0.6	0.8	2.4	-0.6	-1.2	0.5	0.4	-0.5	-1.6
Medication: Paracetamol	1.1	1.9	5.7	-0.9	-1.9	0.9	0.6	0.4	-2.4
Headache pain in last month	0.7	1.2	5.1	-0.4	-1.0	0.5	0.2	-0.6	-2.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	-0.2	-0.6	0.3	1.0	0.1	-0.3
Glaucoma (self-reported)	3.8	4.5	12.5	-1.3	-2.5	2.0	1.4	-0.0	-3.5
Gout (self-reported)	0.4	0.6	1.1	-0.7	-1.0	0.7	-0.2	0.7	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.7	-0.1	-0.4	-0.6	-0.7	-1.0	-1.6
Medication: Amlodipine	0.3	0.4	0.8	0.7	0.5	-0.9	-0.5	-0.6	-0.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.5	2.1	0.6	-1.0	-1.7	-1.5	-0.3
Birth weight	0.6	1.3	2.6	-0.1	0.6	1.2	-1.3	1.6	1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.3	0.5	-1.3	0.4	0.2	-0.7	-2.1
High blood pressure (siblings)	0.2	0.2	0.7	0.3	0.7	-0.1	-0.8	-0.2	0.0
Forced vital capacity (FVC), Best measure	1.2	4.6	8.4	-2.7	-0.4	2.9	1.8	2.7	1.1
Body fat percentage	0.6	2.5	4.4	-1.7	-2.1	1.7	1.3	1.6	-0.6
Leg fat percentage (right)	0.3	1.2	2.2	-1.1	-1.4	1.0	0.7	1.5	-0.5
Arm fat-free mass (right)	0.2	1.2	3.0	-0.2	-1.7	0.7	0.8	-0.4	-1.7
Exposure to tobacco smoke outside home	1.0	1.4	2.3	-1.0	-1.4	1.5	1.2	0.9	-0.9
Comparative body size at age 10	0.4	1.0	4.2	0.4	-1.2	0.1	0.1	-0.4	-2.1
Number of full brothers	0.9	1.2	4.7	0.5	-1.1	-0.1	-0.4	-0.8	-2.2
Worry too long after embarrassment	1.8	3.0	5.7	1.4	2.4	-1.9	-1.8	-1.8	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.3	-0.3	1.5	0.3	-0.3	0.7	0.3
Wheeze or whistling in the chest in last year	1.9	3.4	15.2	0.6	-0.8	0.2	-1.4	-1.4	-3.9
Number of children fathered	0.5	0.6	1.4	-0.3	-1.0	-0.3	1.2	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.1	1.4	0.5	-1.0	-0.5	-1.4	-0.3
Age at first live birth	1.2	2.2	4.8	2.1	0.5	-1.1	-1.5	-2.2	-0.3
Pulse wave peak to peak time	0.7	0.8	1.3	0.9	1.1	-0.8	-1.1	-0.8	0.4
Health satisfaction	0.2	0.3	0.9	0.4	-1.0	-0.5	0.0	-0.0	-0.7
Shortness of breath walking on level ground	0.4	0.5	1.9	-0.2	-1.4	-0.1	0.6	0.6	-0.7
Qualifications: College or University degree	0.9	2.9	5.9	2.4	1.3	-1.4	-1.6	-2.2	0.1
Eye problems/disorders: None of the above	1.3	1.5	4.3	-0.8	1.5	0.2	-0.3	1.4	2.1
Mouth/teeth dental problems: Loose teeth	5.6	6.6	14.4	3.1	2.3	-3.8	-1.8	-2.7	-0.2
Emphysema/chronic bronchitis	1.1	1.2	7.0	-0.2	-0.4	0.2	-0.0	0.0	-2.6
Medication for pain relief, constipation, heartburn	1.3	2.3	5.5	0.6	2.4	-1.4	-0.5	-1.0	2.1
Neck or shoulder pain in last month	0.4	0.6	2.1	0.2	-0.1	-0.7	-0.4	-1.0	-1.5
Medication: Blood pressure	0.1	0.2	0.6	-0.0	0.8	-0.5	-0.5	-0.2	-0.3
Angina (self-reported)	0.5	0.7	1.9	-1.4	0.1	0.6	-0.4	0.9	-0.9
Migraine (self-reported)	2.4	2.9	6.6	-2.2	-1.6	1.6	2.6	1.1	0.3
Medication: Ibuprofen	0.9	1.1	3.6	-0.7	-0.9	1.1	-0.6	0.3	-1.9
Medication: Allopurinol	1.6	2.1	5.0	-1.0	-2.1	1.2	0.3	0.7	-2.2
Medication: Omeprazole	0.2	0.3	0.8	0.0	0.9	0.3	-0.7	0.4	0.5
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.5	0.2	-0.4	0.6	-0.6	-0.6
Mean time to correctly identify matches	0.3	0.6	1.8	1.3	-0.7	-0.1	0.1	-1.2	-0.3
Heart disease (mother)	0.4	0.5	1.3	-1.1	0.3	0.6	0.2	0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.3	0.6	-0.8	0.0	-0.5	-0.3
Whole body fat mass	0.4	1.8	4.6	-1.1	-2.1	1.4	0.8	1.0	-1.1
Leg fat mass (right)	0.4	1.6	3.9	-1.0	-2.0	1.2	0.8	1.2	-1.2
Arm predicted mass (right)	0.2	1.1	2.9	0.0	-1.7	0.6	0.7	-0.5	-1.7
Pulse rate, automated reading	1.8	5.9	10.9	3.3	0.9	-3.2	-1.9	-3.1	0.2
Alcohol intake frequency.	0.2	0.4	1.1	0.1	-1.0	0.1	0.5	0.6	0.7
Comparative height size at age 10	0.2	1.1	3.1	-1.1	-0.5	1.8	0.3	1.4	-0.3
Number of full sisters	0.6	0.8	3.6	0.1	0.3	-0.3	0.7	0.6	1.9
Suffer from ‘nerves’	1.8	2.8	6.1	1.5	2.5	-1.4	-1.9	-1.0	1.3
Overall health rating	0.2	0.5	1.7	0.4	-1.0	0.1	0.1	-0.2	-1.3
Chest pain or discomfort	1.7	2.4	7.6	0.2	0.9	-1.6	-1.5	-1.2	-2.8
Had major operations	3.0	3.5	5.9	1.7	2.4	-1.7	-1.9	-2.4	-0.4
Age at last live birth	0.2	0.3	0.9	-0.2	-0.4	0.0	0.1	-0.9	-1.0
Family relationship satisfaction	2.2	2.7	4.0	1.6	1.5	-2.0	-1.5	-1.8	-1.4
Leg pain on walking	0.9	1.1	4.2	-1.2	0.0	0.6	0.2	2.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	8.6	-2.3	-1.5	2.9	1.9	1.3	-1.0
Commuting to job workplace: Car/motor vehicle	4.2	4.8	11.1	-3.3	-1.0	2.3	1.3	2.9	1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	0.7	-0.2	-0.6	-1.1	-0.2	-0.3
Medication: Aspirin	1.2	1.5	4.5	-0.8	-2.1	0.9	1.1	1.1	-0.9
Supplements: Vitamin C	1.3	1.5	5.5	-0.5	-0.5	0.3	2.3	0.7	1.5
Knee pain experienced in last month	0.4	0.6	1.2	1.1	-0.2	-0.9	0.4	-1.1	0.2
Hypertension (Self-reported)	0.2	0.6	2.7	0.3	0.1	-0.1	0.5	-0.6	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.4	1.1	1.2	-0.6	-1.1	-0.3	0.9
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.6	-0.2	0.3	0.6	0.3	0.7
Illnesses of siblings: Diabetes	0.7	0.8	2.5	0.2	-1.6	0.2	-0.0	0.3	-1.6
Smoking status: Previous	0.2	0.4	1.1	-0.8	0.3	1.0	0.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.0	-1.7	0.7	1.1	-0.4	1.3	-0.0
Whole body fat-free mass	0.1	0.8	2.1	0.0	-1.5	0.7	0.3	-0.1	-1.3
Leg fat-free mass (right)	0.3	1.4	4.1	0.0	-2.0	1.0	0.3	-0.2	-1.8
Arm fat percentage (left)	0.2	0.7	2.0	-0.8	-1.4	0.7	0.2	0.6	-0.6
Average weekly red wine intake	0.1	0.1	0.4	-0.3	-0.3	0.6	0.1	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.4	-0.4	-0.2	0.3	-0.0	-0.1	-1.2
Mood swings	0.6	1.2	3.0	0.1	0.9	-0.6	-1.7	0.1	-1.7
Loneliness, isolation	0.8	1.1	3.1	-0.6	-1.8	0.9	0.6	-0.3	-1.5
Long-standing illness, disability or infirmity	0.4	0.7	2.1	0.2	-1.0	0.6	-0.0	0.8	-1.4
Ever had bowel cancer screening	3.7	4.4	7.7	2.3	1.2	-1.8	-1.6	-2.8	-2.4
Diabetes diagnosed by doctor	0.7	1.1	3.9	0.1	-1.5	0.5	-0.1	0.3	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.9	0.1	1.8	-1.7	-0.6	0.2	2.2
Friendships satisfaction	0.1	0.1	0.6	-0.1	0.8	-0.2	-0.1	0.1	-0.1
Qualifications: nursing, teaching	0.5	0.7	2.6	1.2	0.3	-0.3	0.1	-1.6	-0.3
Commuting to job workplace: Walk	4.4	4.7	9.4	3.1	1.2	-2.0	-1.6	-3.0	-1.3
Eye problems/disorders: Cataract	1.4	1.6	3.1	1.6	0.8	-1.5	-1.1	-1.8	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.2	1.2	0.7	-1.4	-0.1	-1.8	0.4
Medication for cholesterol	0.4	0.5	1.6	-1.0	0.0	0.0	-0.0	0.8	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.0	-0.7	0.7	1.1	-0.1	1.4	0.8
Back pain experienced in last month	0.2	0.3	1.1	0.0	0.4	-0.5	-0.4	-0.3	-1.1
Mineral and other dietary supplements	0.4	0.5	1.6	0.8	-0.8	-0.2	-0.2	0.2	-1.3
Breast cancer (self-reported)	0.7	0.8	2.4	-1.3	-0.0	0.4	-0.3	1.6	0.7
Asthma (self-reported)	2.7	5.4	9.5	2.8	2.1	-2.3	-3.1	-2.3	-0.3
Osteoporosis (self-reported)	0.5	0.6	1.1	0.9	0.8	-0.2	-1.0	-1.0	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.4	1.2	0.1	-0.7	-0.7	-0.8	-0.6
Medication: Aspirin	1.1	1.5	3.7	-0.8	-1.9	0.8	1.0	1.2	-1.1
Medication: Gliclazide	0.3	0.4	1.8	0.5	-0.5	-0.0	-0.2	-0.3	-1.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.3	0.9	-0.0	-0.4	0.7	1.1
Smoking status: Current	0.3	0.5	1.5	0.0	-0.6	0.4	0.8	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	10.4	-3.2	-1.4	2.2	2.7	3.2	1.9
Whole body water mass	0.1	0.8	2.2	-0.0	-1.5	0.7	0.3	0.0	-1.3
Leg predicted mass (right)	0.3	1.4	4.0	0.1	-2.0	1.0	0.4	-0.2	-1.7
Arm fat mass (left)	0.1	0.5	1.8	-0.4	-1.4	0.6	-0.0	0.4	-0.9
Number of self-reported non-cancer illnesses	1.0	1.8	3.0	1.7	1.3	-0.9	-1.3	-1.4	-1.3
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.6	-0.0	0.2	-0.2	-0.1	-0.5
Miserableness	0.3	0.5	1.2	-0.6	-0.4	0.9	0.4	1.1	-0.7
Guilty feelings	2.0	3.0	3.4	1.8	1.8	-1.8	-1.8	-1.8	-1.4
Wears glasses or contact lenses	1.8	2.0	4.8	1.2	1.5	-1.2	-1.1	-2.2	-1.0
Ever taken oral contraceptive pill	1.0	1.1	5.3	-0.6	-0.1	-0.1	-0.8	-0.7	-2.3
Hearing aid user	0.4	0.4	1.2	-0.1	0.4	-0.3	-1.1	1.0	0.2
Mother’s age at death	0.2	0.3	0.5	0.1	0.7	-0.6	-0.0	-0.7	0.4
Financial situation satisfaction	0.2	0.2	0.7	0.1	-0.5	-0.2	0.8	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.9	-0.0	1.3	-0.0	0.1	0.9	1.4
Commuting to job workplace: Public transport	3.4	4.1	8.8	3.0	1.4	-2.0	-1.7	-2.4	-1.0
Eye problems/disorders: Glaucoma	4.0	4.7	14.4	-1.5	-2.6	1.6	1.5	-0.3	-3.8
Medication: Blood pressure	0.3	0.6	1.6	0.0	0.1	0.1	1.2	-0.7	-1.3
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.9	-1.5	1.0	0.6	0.5	1.6	1.7
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.5	-0.4	0.7	-0.7	0.8	-0.3	1.6
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.0	-0.6	0.2	-0.0	0.4	0.3
Medication: Bendroflumethiazide	0.4	0.6	1.6	0.6	-0.1	-1.3	0.7	-0.5	-1.1
Medication: Paracetamol	0.7	1.1	4.5	-0.5	-1.2	0.2	0.6	0.1	-2.1
Medication: Lisinopril	2.6	3.3	5.3	2.3	1.9	-2.1	-2.0	-1.6	-0.1
Medication: Atorvastatin	0.2	0.2	0.5	-0.6	0.4	-0.2	-0.6	0.1	0.7
Illnesses of father: High blood pressure	0.6	0.8	2.1	0.7	1.5	-0.6	-1.0	-0.7	0.4
Alcohol drinker status: Never	2.0	2.4	5.8	2.4	0.4	-0.9	-2.4	-1.3	-0.4
Ever smoked	0.3	0.5	2.1	-0.4	1.5	-0.1	-0.2	-0.0	-0.7
Basal metabolic rate	0.2	1.0	2.6	-0.3	-1.6	1.0	0.4	0.3	-1.4
Leg fat percentage (left)	0.2	0.6	1.8	-0.6	-1.3	0.7	0.4	0.8	-0.7
Arm fat-free mass (left)	0.1	0.7	1.9	-0.4	-1.4	0.8	0.5	0.3	-1.1
Number of operations (self-reported)	3.0	4.5	8.6	1.8	2.6	-2.3	-1.9	-2.9	-0.0
Average weekly beer plus cider intake	0.2	0.3	0.5	0.7	0.3	-0.6	-0.3	-0.6	-0.4
Irritability	0.2	0.3	0.9	-0.1	0.6	0.1	-1.0	-0.2	-0.4
Risk taking	0.6	0.8	1.7	-1.2	-0.4	0.5	1.3	0.5	-1.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	-0.8	0.6	0.8	-0.2	0.3	-0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.0	-0.8	0.2	-0.2	-0.4	-1.2
Age started oral contraceptive pill	1.2	1.5	3.3	1.7	0.4	-1.8	-0.6	-1.4	-0.7
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.7	-0.7	-0.3	-0.5	-0.1	-0.2
Ever depressed for a whole week	2.6	3.1	15.5	-0.8	-1.3	1.0	0.2	-0.4	-3.9
Unable to work because of sickness or disability	0.2	0.3	0.6	0.7	0.7	-0.5	-0.7	-0.1	-0.1
Commuting to job workplace: Cycle	6.1	7.4	13.4	3.7	2.2	-2.7	-3.1	-3.0	-0.1
Myopia	0.9	1.3	5.4	0.8	2.3	-0.4	-0.8	-0.9	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.4	-0.1	0.1	-0.2	-0.7	0.5	1.5
Cholesterol lowering medication	0.5	0.8	1.5	1.2	-0.2	-0.7	-0.8	-0.6	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.0	0.4	0.6	-0.2	0.5	0.1
Pain experienced in last month	0.2	0.3	0.9	0.5	0.5	-0.1	-0.8	0.2	0.9
Supplements: Calcium	0.3	0.4	0.8	0.2	0.2	-0.3	-0.7	-0.8	-0.9
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	0.5	-1.2	-0.3	1.1	-0.9	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.4	0.4	1.6	-1.3	-1.3	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.2	-0.8	-1.5	0.7	0.5	-0.4	-1.8
Heart disease (siblings)	2.5	3.1	7.0	-1.1	-2.6	1.8	1.0	1.1	-2.2
Alcohol drinker status: Previous	1.8	2.1	5.3	-1.3	-1.3	1.3	1.3	2.3	0.6
Pack years of smoking	3.5	5.1	12.0	2.9	1.9	-2.0	-3.5	-1.4	-0.9
Impedance of whole body	0.8	4.0	10.4	-3.2	0.5	1.9	1.5	2.5	1.1
Leg fat mass (left)	0.4	1.5	4.2	-0.7	-2.0	1.1	0.6	0.7	-1.5
Arm predicted mass (left)	0.1	0.7	1.7	-0.3	-1.3	0.7	0.5	0.2	-1.2