Hub : Genes

ZMAT5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Not Sun Exposed Suprapubic 0.099 0.041 0.0019 0.000 NA -0.004 NA -0.003 0.30000 NA 0.6100 NA 0.5000
2 GTEx Skin Sun Exposed Lower leg 0.060 0.026 0.0013 0.027 NA 0.023 NA 0.013 0.00260 NA 0.0045 NA 0.0260
3 GTEx Testis 0.089 0.046 0.0068 0.080 NA 0.034 NA 0.053 0.00021 NA 0.0120 NA 0.0023
4 GTEx Whole Blood 0.073 0.037 0.0076 0.019 NA 0.017 NA 0.026 0.00600 NA 0.0097 NA 0.0017

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 2.5 1.6 1.1 0.2 0.8
Bipolar Disorder or Schizophrenia 0.2 0.4 1.5 0.3 -0.4 1.2 -0.1
Depressed Affect (Nagel 2018) 4.6 9.8 16.7 3.2 3.4 -4.1 0.6
Depression (Nagel 2018) 1.0 1.5 3.0 1.7 0.9 -1.4 -0.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.6 0.5 0.6 -0.8 -0.5
Neuroticism (Nagel 2018) 3.8 8.8 13.1 3.6 2.9 -3.6 0.7
Schizophrenia (2018) 0.7 1.4 2.1 -1.0 -1.4 1.4 -0.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.7 -0.4 0.1 0.8
Worry (Nagel 2018) 3.0 6.4 13.0 3.6 2.5 -2.4 0.9
Alzheimer’s Disease (in mother) 0.4 0.5 1.2 0.8 0.1 -0.0 -1.1
Alzheimer’s Disease (in father) 1.8 2.0 4.9 -1.0 -0.8 1.2 -2.2
Alzheimer’s Disease (including proxy) 0.9 1.3 2.7 -0.1 -0.7 1.4 -1.6
Crohns Disease (2017) 0.9 2.1 4.5 -0.8 -1.0 1.5 2.1
Irritable Bowel Disease (IBD) 3.0 7.3 11.3 -2.1 -2.5 2.7 3.4
Ulcerative Colitis (UC) 4.1 7.8 8.6 -2.5 -2.8 2.9 2.9
Major Depression (MDD) 1.4 1.7 3.7 1.0 1.1 -1.0 -1.9
Reaction Time 0.8 1.5 2.9 1.7 0.8 -1.2 -1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.1 0.4 1.1 -0.8 -0.1
Breast Cancer 0.2 0.4 1.0 1.0 -0.4 0.6 0.4
Ovarian Cancer 0.7 1.0 1.5 -1.2 -0.7 0.8 -1.1
Prostate Cancer 2.8 3.9 9.5 -1.6 -1.9 3.1 0.1
Age at First Birth 4.4 6.4 10.9 -2.6 -3.3 2.7 -0.9
Bipolar Disorder (2011) 0.8 0.8 1.6 0.5 0.2 1.1 1.2
Body Mass Index (BMI) (2010) 1.4 1.9 3.3 -1.6 -0.7 1.0 -1.8
Coronary Artery Disease (CAD) 0.6 0.7 2.0 -0.6 -0.6 -0.5 1.4
Crohns Disease (2012) 2.3 3.7 6.5 -1.8 -1.2 2.5 1.9
Mean Putamen Volume 0.5 0.6 1.9 -0.1 0.2 0.5 -1.4
Fasting Glucose 3.1 3.7 3.9 -1.8 -1.9 2.0 -2.0
HbA1C 1.0 1.1 3.4 0.5 0.3 -1.8 0.7
HDL Cholesterol 3.9 6.6 11.0 -2.6 -2.7 3.3 -1.1
LDL Cholesterol 0.1 0.1 0.2 0.4 0.2 0.2 0.5
Lupus 0.3 0.4 1.1 -0.4 0.2 -0.5 1.1
Neuroticism (2016) 0.7 1.0 1.7 1.1 1.0 -1.3 0.3
Primary Biliary Cirrhosis 0.7 0.9 1.8 1.1 0.4 -1.4 0.7
Rheumatoid Arthritis 0.5 0.6 1.9 0.5 0.5 -1.4 0.3
Schizophrenia (2014) 0.1 0.2 0.4 0.2 -0.3 0.6 0.3
Triglycerides 0.4 0.6 1.3 0.2 0.4 -1.2 1.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.8 -0.1 0.4 -1.3 -0.7
Ulcerative Colitis 4.0 5.8 6.2 -2.5 -2.4 2.3 2.5
Blood Eosinophil Count 1.4 10.5 14.3 -3.1 -2.9 3.8 -3.2
Blood Platelet Count 2.8 32.3 46.1 -5.7 -4.0 5.9 -6.8
Blood Red Count 0.5 5.1 9.8 1.3 2.4 -3.1 -1.8
Blood White Count 3.9 28.9 40.3 -6.3 -6.0 5.6 -2.8
Heel T-Score 0.3 2.4 7.9 0.5 1.0 -0.5 -2.8
BMI 1.2 6.7 16.2 -4.0 -1.8 1.7 -2.1
Height 0.9 18.0 33.8 -4.9 -3.8 5.8 -0.0
Waist Hip Ratio (WHR) 0.8 3.6 9.9 1.1 1.8 -3.1 0.1
Systolic Blood Pressure 0.4 1.9 4.6 -2.1 -1.2 -0.6 -1.1
Smoking Status 0.1 0.3 0.6 -0.8 -0.2 -0.6 -0.1
Allergy or Eczema 1.5 4.1 7.3 -1.5 -1.7 2.7 -1.9
Cardiovascular Disease 0.7 2.2 5.0 -0.4 1.0 -1.7 2.2
Hypothyroidism (self reported) 6.6 15.2 25.1 3.9 5.0 -4.5 -0.5
Respiratory disease 0.3 0.6 1.5 -0.1 -0.3 1.0 -1.2
Type 2 Diabetes (T2D) (2018) 1.1 2.1 4.7 -2.2 -1.0 0.7 1.4
Lung FEV1/FVC ratio 7.1 35.8 64.8 5.2 8.1 -6.1 3.8
Lung FVC 2.8 14.3 27.8 -4.4 -3.0 5.3 -1.0
Neuroticism 4.2 10.2 17.4 4.2 3.2 -3.6 0.1
Chronotype (morning person) 2.9 6.8 13.7 3.7 2.2 -2.8 1.0
Hair Pigment 0.0 0.4 1.3 -0.0 0.4 0.3 -1.1
Tanning 0.0 0.3 1.3 -0.0 -0.1 1.1 -0.1
Hand grip strength (left) 2.5 6.6 13.2 -2.6 -2.5 3.6 0.0
Number of treatments/medications taken 0.4 0.7 1.8 -0.6 -1.3 0.0 -0.9
Average weekly spirits intake 0.3 0.4 0.7 -0.8 -0.3 0.2 -0.8
Sensitivity / hurt feelings 6.0 10.3 13.1 3.6 3.6 -3.5 1.8
Frequency of depressed mood in last 2 weeks 1.6 2.2 4.6 2.1 1.3 -1.6 -0.1
Hearing difficulty/problems: Yes 6.0 9.1 19.0 -2.8 -4.4 3.0 0.7
Relative age of first facial hair 1.0 2.0 3.9 -0.4 -1.4 1.3 -2.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 -0.0 -0.9 0.4 0.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.7 -1.3 -1.0 1.1 0.2
Ever had hysterectomy (womb removed) 0.7 0.7 1.4 -1.2 -1.2 -0.3 0.3
Systolic blood pressure, automated reading 1.6 4.7 9.7 -2.4 -1.7 0.6 -3.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.3 -1.5 -0.4 0.9 -0.7
Angina 0.8 1.0 1.7 0.9 0.3 -1.2 1.3
Medication for hormone replacement therapy 0.1 0.1 0.3 0.1 0.4 0.5 -0.0
Vitamin and mineral supplements 0.4 0.5 1.4 -0.3 1.2 -0.6 -0.3
Supplements: Zinc 0.9 0.9 2.8 -0.7 -0.6 0.4 -1.7
Medication: Co-codamol 0.5 0.6 1.2 -0.4 -1.0 -0.2 -1.1
Medication: Metformin 2.4 3.3 7.3 -2.7 -1.8 1.7 -0.0
Diabetes (father) 0.3 0.4 0.9 -0.9 -0.8 0.4 -0.3
Diabetes (mother) 1.9 2.5 5.2 -2.3 -1.6 1.4 -0.4
Severe depression (siblings) 0.4 0.5 1.0 0.2 -1.0 0.9 0.2
Pack years adult smoking proportion 0.3 0.5 2.0 -0.1 0.1 -0.0 1.4
Impedance of leg (right) 2.4 11.4 16.8 3.7 3.8 -4.1 0.9
Leg fat-free mass (left) 2.4 12.7 23.3 -4.8 -3.4 3.9 -0.9
Trunk fat percentage 0.6 2.3 6.6 -2.6 -1.0 0.2 -1.2
Hand grip strength (right) 3.8 10.3 18.0 -3.5 -3.0 4.2 -1.4
Townsend deprivation index at recruitment 2.2 3.0 5.6 1.3 1.9 -2.4 -1.0
Current tobacco smoking 0.3 0.5 1.0 -0.7 0.1 -0.6 -1.0
Average weekly fortified wine intake 0.1 0.1 0.3 0.5 0.5 -0.3 -0.1
Maternal smoking around birth 0.7 1.1 2.9 -1.2 -0.1 0.1 -1.7
Fed-up feelings 5.7 10.4 16.7 3.7 3.1 -4.1 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 0.7 -0.6 -0.5 -0.4
Relative age voice broke 1.7 2.6 4.3 -0.9 -1.4 2.1 -1.8
Taking other prescription medications 0.5 0.8 2.2 -0.7 -1.5 0.6 -0.3
Age when periods started (menarche) 3.3 7.9 10.1 -2.7 -2.7 3.2 -2.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.0 -0.7 -0.4 0.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.2 -0.4 0.6 -0.7 -1.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.1 0.0 0.9 -1.4 0.2
Qualifications: CSEs or equivalent 0.8 1.0 2.2 0.4 1.0 -1.5 0.8
Serious illness, injury or assault to yourself 0.0 0.1 0.1 0.1 0.3 -0.3 0.2
High blood pressure 0.4 1.2 3.6 -1.9 -1.1 -0.3 0.4
Hayfever, allergic rhinitis or eczema 0.6 1.2 2.6 -0.7 -0.7 1.6 -1.1
Multivitamins +/- minerals 0.1 0.2 0.3 0.6 -0.3 -0.3 0.5
Stomach or abdominal pain in last month 0.9 1.1 3.0 0.4 0.4 -1.7 -1.0
Supplements: Glucosamine 0.9 1.2 2.7 -0.6 -1.6 0.7 1.1
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 2.2 1.2 0.6 -1.5 1.5
Medication: Atenolol 1.4 1.8 4.1 0.5 1.1 -2.0 1.3
Medication: Levothyroxine sodium 6.3 10.7 18.7 2.7 3.9 -4.3 1.4
Sitting height 0.9 6.2 9.3 -2.7 -2.3 3.0 1.7
Chronic bronchitis/emphysema (father) 1.1 1.3 3.2 -0.4 -1.3 -0.7 -1.8
High blood pressure (mother) 0.6 0.8 1.5 -1.0 -1.2 0.4 -0.8
Body mass index (BMI) 1.3 5.6 12.7 -3.6 -2.0 1.5 -1.8
Impedance of leg (left) 1.6 7.6 11.5 3.0 3.1 -3.4 0.5
Leg predicted mass (left) 2.4 12.8 23.7 -4.9 -3.4 3.9 -0.9
Trunk fat mass 1.4 6.0 14.9 -3.9 -2.1 1.6 -1.5
Waist circumference 0.5 1.9 4.9 -2.2 -0.9 -0.0 -1.4
Number of incorrect matches in round 1.2 1.9 4.4 -0.7 -1.6 2.1 0.4
Past tobacco smoking 0.0 0.0 0.1 -0.1 0.0 -0.4 0.1
Alcohol usually taken with meals 0.3 0.4 1.0 -1.0 -0.4 0.7 0.1
Nervous feelings 2.0 3.7 9.3 3.0 1.7 -1.6 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.7 1.6 0.8 -1.2 -0.2
Hearing difficulty/problems with background noise 0.9 1.4 4.2 -0.6 -2.0 1.0 0.2
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 0.7 0.3 -0.9 0.3
Had menopause 3.2 4.0 5.2 -2.1 -2.3 2.1 -1.4
Had other major operations 0.7 0.9 1.6 -0.7 -1.1 1.3 -0.4
Forced vital capacity (FVC) 2.0 7.9 14.5 -3.6 -2.0 3.8 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 2.7 -0.0 1.6 -1.3 -1.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 -0.9 0.2 -0.2 -0.9
Qualifications: None of the above 1.0 2.1 4.4 0.9 1.8 -2.1 0.3
Financial difficulties in last 2 years 0.1 0.2 0.3 -0.1 0.5 -0.5 0.4
Mouth/teeth dental problems 2.7 4.2 8.5 -1.6 -2.9 2.3 0.8
Heart attack 0.5 0.6 1.6 0.6 -0.0 -0.7 1.3
Allergy 1.7 3.8 5.3 1.7 1.7 -2.3 2.0
Pain all over the body in last month 0.9 1.0 2.5 -0.8 -0.2 -0.9 1.6
Diabetes (self-reported) 1.1 1.7 4.7 -2.2 -1.0 0.8 0.7
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 1.1 1.3 -0.5 0.6
Medication: Ramipril 3.2 4.1 8.0 -2.6 -2.8 1.3 -0.3
Medication: Simvastatin 0.2 0.3 0.7 -0.6 -0.4 -0.2 -0.8
Fluid intelligence score 1.2 2.4 4.6 1.4 2.1 -1.3 -1.3
Illnesses of siblings 0.4 0.5 1.1 0.6 0.3 1.1 0.8
Neuroticism score 6.1 12.7 19.3 4.4 3.8 -4.1 0.2
Weight 2.4 11.9 24.9 -5.0 -3.2 3.1 -1.6
Impedance of arm (right) 2.6 12.3 19.3 4.4 3.4 -3.8 1.9
Arm fat percentage (right) 0.4 1.4 3.8 -1.9 -0.7 -0.0 -1.2
Trunk fat-free mass 2.3 13.5 22.1 -4.7 -3.4 4.3 -1.3
Hip circumference 0.2 0.6 2.1 -1.4 -0.2 -0.0 -0.7
Time employed in main current job 2.2 2.5 5.5 -1.5 -2.3 1.4 -0.2
Alcohol intake versus 10 years previously 1.1 1.7 2.2 1.1 1.4 -1.1 -1.5
Father’s age at death 0.1 0.2 0.6 -0.1 -0.4 0.7 -0.1
Worrier / anxious feelings 1.4 2.7 6.0 2.4 1.6 -1.5 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.3 0.4 0.1 -1.0 -1.2
Falls in the last year 0.1 0.2 0.5 -0.2 -0.3 -0.7 -0.4
Hair/balding pattern: Pattern 3 0.6 1.0 1.7 -1.2 -1.3 0.6 0.5
Number of live births 7.6 10.8 18.5 3.0 4.3 -3.8 1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.8 -1.1 1.0 1.3 0.7
Pulse rate 0.0 0.0 0.1 0.2 -0.1 -0.2 -0.2
Happiness 0.2 0.2 0.6 0.8 -0.1 -0.3 0.3
Noisy workplace 0.3 0.4 0.8 0.0 -0.9 0.8 0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.3 -0.4 -1.2 1.5 -1.1
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.6 0.7 1.2 -1.9 0.5
Mouth/teeth dental problems: Dentures 2.1 3.5 7.4 1.2 2.7 -2.2 -0.5
Asthma 0.1 0.3 0.9 -0.1 -0.2 0.9 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.3 -0.4 1.1 -0.8 -1.1
Medication: Cholesterol lowering 1.4 2.2 6.9 -1.0 -2.6 0.8 0.4
Depression (self-reported) 0.5 0.6 1.1 0.5 1.0 -1.0 0.4
Medication: Lansoprazole 0.9 1.0 2.3 -0.1 1.5 -0.8 -1.1
Prospective memory result 0.3 0.3 0.9 0.0 -1.0 0.5 -0.4
Lung cancer (father) 0.6 0.7 2.2 0.1 -0.4 0.7 -1.5
Illnesses of mother 1.4 1.7 4.2 1.1 2.0 -1.1 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 3.4 -0.3 1.3 0.9 1.8
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -0.9 -0.2 -1.1 -0.5
Impedance of arm (left) 2.3 10.9 16.4 4.1 3.2 -3.6 1.9
Arm fat mass (right) 1.0 4.1 10.0 -3.2 -1.6 1.3 -1.4
Trunk predicted mass 2.3 13.0 21.2 -4.6 -3.3 4.3 -1.3
Standing height 0.9 8.5 13.8 -3.5 -2.8 3.7 0.3
Length of working week for main job 0.5 0.6 1.5 -0.7 -0.6 1.2 0.1
Exposure to tobacco smoke at home 0.5 0.5 2.0 1.4 0.3 -0.2 -0.0
Breastfed as a baby 2.1 2.6 3.8 -1.9 -1.7 1.9 0.2
Tense / ‘highly strung’ 1.8 3.1 6.4 2.5 2.0 -1.3 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 0.1 1.0 -0.5 0.1
Hair/balding pattern: Pattern 4 1.5 3.6 5.8 -2.4 -1.7 2.4 0.2
Birth weight of first child 0.7 1.2 3.2 -0.3 -1.8 1.3 0.3
Peak expiratory flow (PEF) 0.3 0.7 1.7 -0.6 0.6 0.6 1.3
Pulse wave reflection index 0.9 1.1 2.6 1.0 1.0 -1.6 0.1
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.0 1.4 0.1 -0.8 0.7
Loud music exposure frequency 0.9 1.0 1.3 1.0 1.2 -0.6 -1.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 3.5 -1.2 -1.9 1.3 -0.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.9 1.1 1.0 -1.4 -0.7
Blood clot in the leg (DVT) 3.6 4.6 7.1 -2.1 -2.0 2.7 -1.7
Medication: Paracetamol 1.1 1.8 4.4 0.9 1.3 -2.1 0.7
Headache pain in last month 3.4 5.9 9.7 2.3 3.0 -3.1 0.3
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.7 0.8 1.7 0.4 -0.3
Glaucoma (self-reported) 1.6 1.9 3.1 -1.6 -1.8 1.1 0.7
Gout (self-reported) 0.8 1.1 1.9 -1.2 -1.4 1.0 -0.2
Hypothyroidism/myxoedema (self-reported) 5.3 10.4 18.0 2.9 3.9 -4.2 -0.1
Medication: Amlodipine 0.2 0.3 0.7 -0.5 -0.6 -0.3 -0.8
Medication: Ventolin 100micrograms inhaler 1.4 1.8 2.3 -1.0 -1.4 1.5 -1.4
Birth weight 6.3 13.7 22.8 -2.8 -4.8 4.5 -1.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 -0.6 -1.2 0.3 0.8
High blood pressure (siblings) 0.4 0.6 1.4 -0.2 0.2 -1.2 -1.0
Forced vital capacity (FVC), Best measure 1.4 5.0 10.6 -2.7 -1.3 3.3 0.5
Body fat percentage 0.9 3.4 9.3 -3.0 -1.2 0.4 -1.6
Leg fat percentage (right) 0.9 3.3 7.9 -2.8 -1.0 0.2 -2.0
Arm fat-free mass (right) 2.9 14.8 26.6 -5.2 -3.6 4.3 -1.3
Exposure to tobacco smoke outside home 0.2 0.3 0.7 -0.8 -0.2 0.7 0.1
Comparative body size at age 10 4.2 11.6 18.8 -4.3 -3.6 3.8 -0.4
Number of full brothers 1.5 1.9 4.5 0.1 2.1 -1.8 0.0
Worry too long after embarrassment 0.5 0.8 3.0 0.2 0.0 0.5 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 0.9 0.5 -0.6 -0.1
Wheeze or whistling in the chest in last year 1.1 1.9 5.3 0.6 1.1 -2.3 0.7
Number of children fathered 3.4 3.8 5.9 1.4 2.4 -2.4 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 -0.0 -0.7 0.1 -0.7
Age at first live birth 2.6 4.7 9.8 -1.4 -3.1 2.7 -0.1
Pulse wave peak to peak time 0.6 0.7 2.3 0.6 -0.1 1.5 0.2
Health satisfaction 1.2 1.6 3.0 -1.1 -1.7 0.8 -1.2
Shortness of breath walking on level ground 0.4 0.4 0.7 0.7 0.7 -0.8 -0.2
Qualifications: College or University degree 3.9 12.2 20.6 -2.8 -4.1 4.5 -1.9
Eye problems/disorders: None of the above 0.8 0.9 2.8 1.7 0.3 -0.8 0.5
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.5 0.1 0.7 -0.4 -0.1
Emphysema/chronic bronchitis 0.6 0.7 1.7 -1.3 -0.7 -0.3 -0.8
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.2 0.0 0.8 0.8
Neck or shoulder pain in last month 0.4 0.6 1.6 0.8 -0.3 0.2 -1.3
Medication: Blood pressure 0.9 1.6 3.0 -1.7 -1.7 -0.8 0.3
Angina (self-reported) 1.0 1.3 2.2 0.8 0.3 -1.4 1.5
Migraine (self-reported) 4.8 5.9 9.6 3.1 2.3 -2.6 1.4
Medication: Ibuprofen 0.6 0.7 2.2 -0.6 0.3 -0.5 -1.5
Medication: Allopurinol 1.5 2.0 3.8 -1.6 -1.9 1.1 -0.8
Medication: Omeprazole 1.1 1.3 2.3 1.5 0.5 -1.4 0.7
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.6 -0.7 0.7 0.1
Mean time to correctly identify matches 0.2 0.4 1.3 0.3 -0.2 0.1 -1.1
Heart disease (mother) 0.7 0.8 1.3 1.1 -0.5 -0.8 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.4 5.2 8.2 2.5 2.9 -2.5 0.2
Whole body fat mass 1.6 6.5 16.1 -4.0 -2.1 1.6 -1.7
Leg fat mass (right) 1.8 7.1 17.0 -4.1 -2.1 1.7 -2.0
Arm predicted mass (right) 3.0 15.2 27.8 -5.3 -3.6 4.3 -1.3
Pulse rate, automated reading 0.2 0.5 1.1 0.7 0.0 -0.6 -1.0
Alcohol intake frequency. 0.3 0.7 1.8 0.7 0.5 -1.4 0.5
Comparative height size at age 10 0.7 3.6 6.5 -2.6 -1.4 2.4 0.0
Number of full sisters 1.3 1.5 3.3 0.9 1.8 -1.3 -0.6
Suffer from ‘nerves’ 3.4 5.4 7.3 2.6 2.2 -2.7 1.5
Overall health rating 0.4 0.9 2.7 0.1 -0.7 -0.5 -1.6
Chest pain or discomfort 0.2 0.3 0.8 0.7 0.2 -0.2 -0.9
Had major operations 1.2 1.4 3.7 1.9 1.1 -0.6 -0.5
Age at last live birth 0.9 1.3 2.6 -0.9 -1.6 1.2 0.6
Family relationship satisfaction 1.8 2.2 4.5 2.1 1.4 -1.3 0.8
Leg pain on walking 1.2 1.6 3.1 -0.9 -1.5 1.8 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.5 -0.1 0.0 0.5
Commuting to job workplace: Car/motor vehicle 1.7 2.0 4.5 1.1 1.5 -2.1 0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -0.1 -0.3 0.8 -1.0
Medication: Aspirin 0.0 0.0 0.0 -0.0 -0.1 -0.1 -0.0
Supplements: Vitamin C 0.3 0.3 0.7 0.2 -0.7 0.4 -0.8
Knee pain experienced in last month 0.9 1.4 3.3 -1.8 -0.6 1.4 -0.3
Hypertension (Self-reported) 0.5 1.3 3.8 -1.9 -0.9 -0.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.3 1.0 1.1 -0.9 -0.5
Illnesses of father: Heart disease 1.8 2.5 9.0 0.7 -0.5 -0.4 3.0
Illnesses of siblings: Diabetes 0.1 0.2 0.5 -0.7 -0.1 0.1 0.2
Smoking status: Previous 0.2 0.2 0.6 -0.2 -0.1 0.5 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.0 0.2 -0.1 1.0 1.7
Whole body fat-free mass 2.5 14.5 24.6 -5.0 -3.6 4.3 -1.2
Leg fat-free mass (right) 2.8 14.9 26.0 -5.1 -3.7 4.3 -1.0
Arm fat percentage (left) 0.5 2.1 5.8 -2.4 -1.0 0.3 -1.3
Average weekly red wine intake 1.7 2.5 3.6 -1.7 -1.7 1.9 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.9 0.3 0.1 0.1 1.0
Mood swings 8.7 15.8 21.8 4.3 4.6 -4.7 1.3
Loneliness, isolation 0.7 1.0 1.9 0.9 0.8 -1.4 0.6
Long-standing illness, disability or infirmity 0.5 0.7 2.6 0.1 -1.6 0.2 -0.3
Ever had bowel cancer screening 1.1 1.3 4.4 0.6 0.0 -0.5 -2.1
Diabetes diagnosed by doctor 1.1 1.9 5.0 -2.2 -1.0 0.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 3.4 3.7 6.7 2.6 1.8 -2.1 0.5
Friendships satisfaction 1.2 1.5 2.0 1.4 1.3 -1.4 0.4
Qualifications: nursing, teaching 1.7 2.7 4.9 -1.5 -1.8 2.2 -0.6
Commuting to job workplace: Walk 1.7 1.9 3.0 -0.9 -1.7 1.7 -0.9
Eye problems/disorders: Cataract 0.1 0.1 0.4 -0.6 0.1 0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.8 0.2 0.7 -0.6 -0.9
Medication for cholesterol 0.5 0.8 1.9 -0.2 -1.4 0.7 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.0 0.7 -0.2 0.0 -1.4
Back pain experienced in last month 5.1 7.4 12.1 3.3 2.6 -3.5 -0.3
Mineral and other dietary supplements 0.2 0.3 1.0 -0.3 1.0 -0.3 -0.3
Breast cancer (self-reported) 1.1 1.4 2.1 -1.5 -1.3 1.3 0.1
Asthma (self-reported) 0.2 0.4 1.2 -0.3 -0.4 1.1 -0.3
Osteoporosis (self-reported) 0.4 0.5 1.1 -0.3 -0.9 0.3 -1.1
Osteoarthritis (self-reported) 4.4 5.8 8.9 -2.3 -3.0 3.0 -0.6
Medication: Aspirin 0.0 0.0 0.1 0.1 -0.1 -0.3 -0.0
Medication: Gliclazide 1.1 1.2 3.6 -1.9 -0.8 0.2 -0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 2.3 0.6 1.5 -0.1 -0.3
Smoking status: Current 0.2 0.3 0.6 -0.4 0.2 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 5.0 0.2 2.2 -0.5 1.5
Whole body water mass 2.6 14.7 24.6 -5.0 -3.7 4.4 -1.2
Leg predicted mass (right) 2.8 15.1 25.9 -5.1 -3.8 4.4 -1.0
Arm fat mass (left) 1.2 5.1 12.0 -3.5 -1.9 1.6 -1.4
Number of self-reported non-cancer illnesses 0.1 0.2 0.6 -0.1 -0.8 0.2 -0.5
Average weekly champagne plus white wine intake 0.4 0.6 1.1 1.0 0.1 -0.6 1.0
Miserableness 3.0 5.1 11.1 1.9 2.4 -3.3 0.1
Guilty feelings 1.1 1.6 5.3 0.9 -0.2 -0.4 -2.3
Wears glasses or contact lenses 1.5 1.7 3.5 -1.0 -1.4 1.9 -0.5
Ever taken oral contraceptive pill 0.9 1.0 2.1 0.9 1.4 -0.8 0.7
Hearing aid user 2.2 2.5 4.2 1.4 1.8 -0.7 2.0
Mother’s age at death 1.6 2.0 4.0 -0.5 -1.6 2.0 0.9
Financial situation satisfaction 0.5 0.6 1.9 -0.2 0.4 -0.7 1.4
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 0.7 -0.3 0.7 0.9
Commuting to job workplace: Public transport 0.3 0.4 0.8 -0.3 -0.9 0.9 -0.3
Eye problems/disorders: Glaucoma 1.0 1.2 2.4 -1.6 -0.9 1.3 0.1
Medication: Blood pressure 0.2 0.3 0.5 -0.4 0.5 -0.7 -0.6
Pain type(s) experienced in last month: Hip pain 4.5 5.6 8.5 2.6 2.2 -2.9 1.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.8 0.9 -0.3 0.3 0.5
High cholesterol (Self-reported) 1.0 1.8 3.5 -1.9 -1.5 1.3 -0.4
Medication: Bendroflumethiazide 0.4 0.6 1.4 -0.7 0.4 -1.2 -0.7
Medication: Paracetamol 1.9 2.9 7.3 1.5 1.5 -2.7 0.2
Medication: Lisinopril 0.0 0.0 0.2 -0.4 -0.2 0.1 0.0
Medication: Atorvastatin 1.0 1.2 4.3 -0.2 -2.1 0.4 -0.6
Illnesses of father: High blood pressure 1.7 2.1 3.7 1.9 1.5 -1.5 0.5
Alcohol drinker status: Never 3.0 3.6 5.0 -1.2 -2.0 2.0 -2.2
Ever smoked 0.4 0.7 1.2 0.9 1.1 -0.8 -0.5
Basal metabolic rate 2.5 14.0 25.6 -5.1 -3.5 4.1 -1.4
Leg fat percentage (left) 1.4 5.2 11.9 -3.5 -1.6 0.8 -2.4
Arm fat-free mass (left) 2.5 12.7 22.8 -4.8 -3.2 4.0 -1.3
Number of operations (self-reported) 0.9 1.4 2.4 1.5 1.4 -1.0 -0.1
Average weekly beer plus cider intake 0.8 1.2 3.0 -0.9 -0.4 0.9 -1.7
Irritability 2.1 3.6 6.7 1.8 2.1 -2.6 0.4
Risk taking 2.4 3.5 6.8 1.0 2.5 -2.6 -0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.1 0.3 0.6 0.0
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.8 0.2 -0.9 -0.2
Age started oral contraceptive pill 4.3 5.4 7.1 -2.0 -2.7 2.3 -2.3
Diastolic blood pressure, automated reading 0.5 1.5 4.4 -0.7 -1.1 0.1 -2.1
Ever depressed for a whole week 0.5 0.6 2.1 0.0 1.4 -0.4 0.6
Unable to work because of sickness or disability 0.3 0.3 0.5 0.4 -0.6 0.7 -0.5
Commuting to job workplace: Cycle 0.4 0.4 1.2 0.3 -0.6 1.1 -0.3
Myopia 2.0 2.9 4.8 -1.5 -2.2 2.1 -0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.3 0.9 0.5 1.2 -0.4
Cholesterol lowering medication 0.4 0.5 1.7 -1.3 0.1 -0.1 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.6 0.7 -0.0 -0.3 0.2
Pain experienced in last month 0.5 0.8 1.8 -0.3 -1.1 1.4 -0.1
Supplements: Calcium 0.6 0.7 1.3 0.5 -0.9 0.6 1.1
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 -0.9 -0.4 0.7 0.2
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.6 0.4 -0.3 -0.6 1.3
Deep venous thrombosis (DVT) (self-reported) 3.7 4.8 7.1 -2.3 -2.0 2.7 -1.6
Heart disease (siblings) 2.1 2.6 3.7 -1.9 -1.9 -0.3 1.7
Alcohol drinker status: Previous 0.7 0.8 2.2 0.4 -0.5 -0.7 1.5
Pack years of smoking 0.2 0.3 1.1 -0.4 -0.2 0.1 1.0
Impedance of whole body 2.7 14.0 18.6 4.3 3.9 -4.3 1.9
Leg fat mass (left) 2.3 8.9 20.5 -4.5 -2.5 2.1 -2.1
Arm predicted mass (left) 2.5 12.6 22.3 -4.7 -3.2 4.0 -1.4