Hub : Genes

UQCR10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1210	0.0570	9.3e-03	0.031	NA	0.033	NA	0.056	3.4e-02	NA	3.1e-02	NA	6.6e-03
2	GTEx	Heart Left Ventricle	0.1200	0.0568	8.7e-03	0.022	NA	0.045	NA	0.009	2.4e-02	NA	2.0e-03	NA	1.1e-01
3	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0280	2.2e-05	0.097	NA	0.086	NA	0.091	2.1e-08	NA	1.2e-07	NA	5.5e-08
4	TCGA	Brain Lower Grade Glioma	0.0477	0.0273	3.1e-03	-0.001	0.012	0.013	NA	0.001	4.1e-01	0.013	1.1e-02	NA	2.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.5	2.4	9.0	-0.5	-3.0	0.1	-0.7
Bipolar Disorder or Schizophrenia	2.1	5.2	11.7	0.9	-3.4	-1.2	-2.6
Depressed Affect (Nagel 2018)	3.9	8.3	12.5	-3.5	1.5	3.1	3.0
Depression (Nagel 2018)	0.7	1.0	1.8	-1.2	0.9	0.2	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	-1.0	0.4	0.8	0.0
Neuroticism (Nagel 2018)	2.1	4.9	7.7	-2.8	0.3	2.6	2.3
Schizophrenia (2018)	2.0	4.2	8.1	1.5	-2.0	-1.6	-2.8
Schizophrenia vs Biploar Disorder	0.9	1.2	4.2	0.6	0.6	-0.2	-2.1
Worry (Nagel 2018)	1.1	2.3	5.2	-2.3	-0.5	1.8	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	-0.8	-1.1	0.4	0.5
Alzheimer’s Disease (in father)	1.2	1.3	2.7	-1.0	1.2	0.2	1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.7	-0.7	0.1	0.8
Crohns Disease (2017)	2.1	4.7	7.8	2.8	-0.1	-2.0	-2.6
Irritable Bowel Disease (IBD)	5.6	13.2	24.1	4.9	-0.4	-3.9	-3.7
Ulcerative Colitis (UC)	7.1	13.2	23.2	4.8	-0.9	-4.0	-3.6
Major Depression (MDD)	1.4	1.7	3.2	-1.6	0.6	0.7	1.8
Reaction Time	1.3	2.5	7.3	-1.0	-2.7	1.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.4	-1.2	0.2	1.2	-0.0
Breast Cancer	0.6	1.5	3.5	0.8	-1.9	-1.1	-0.9
Ovarian Cancer	0.7	0.9	1.3	0.8	1.1	-1.1	0.7
Prostate Cancer	3.2	4.5	6.5	2.3	-0.6	-2.5	-2.5
Age at First Birth	2.9	4.2	9.2	2.8	-0.2	-3.0	-0.2
Bipolar Disorder (2011)	3.3	3.2	6.2	1.0	-2.5	-0.9	-2.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	1.0	-0.3	-1.0	-0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.3	0.7	0.3	-0.8	1.1
Crohns Disease (2012)	3.6	5.9	10.4	3.0	-0.0	-2.0	-3.2
Mean Putamen Volume	0.2	0.2	0.3	0.4	0.1	-0.6	0.4
Fasting Glucose	1.5	1.8	3.7	1.9	0.6	-1.6	0.6
HbA1C	1.5	1.6	5.0	0.4	1.2	-0.2	2.2
HDL Cholesterol	1.8	3.0	6.2	2.0	0.8	-2.5	-1.0
LDL Cholesterol	0.2	0.3	0.6	0.8	-0.6	-0.4	-0.5
Lupus	0.1	0.1	0.1	-0.3	-0.4	0.4	0.0
Neuroticism (2016)	1.1	1.5	2.8	-1.0	1.7	1.0	1.1
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.2	-0.1	0.2	0.3
Rheumatoid Arthritis	0.6	0.8	1.4	-0.6	-1.0	0.6	1.2
Schizophrenia (2014)	2.0	4.4	9.9	1.0	-3.1	-0.9	-2.5
Triglycerides	0.6	0.9	1.9	-0.5	1.4	1.1	0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	0.9	-0.1	-0.8	1.0
Ulcerative Colitis	5.1	7.4	14.0	3.7	-0.3	-2.9	-2.6
Blood Eosinophil Count	0.2	1.2	3.5	0.9	0.7	-1.9	0.4
Blood Platelet Count	0.3	4.0	11.0	1.4	-1.5	-3.3	0.9
Blood Red Count	0.3	3.2	7.2	-2.1	-1.1	2.7	-0.4
Blood White Count	2.4	17.4	33.8	5.8	-1.5	-5.5	-1.9
Heel T-Score	1.9	14.9	31.2	-5.6	-0.2	5.3	0.2
BMI	0.2	1.3	2.1	1.0	1.5	-1.3	0.6
Height	0.4	7.1	13.2	3.6	0.8	-2.3	-3.0
Waist Hip Ratio (WHR)	1.1	4.8	10.5	-1.0	3.2	0.2	2.8
Systolic Blood Pressure	1.8	8.9	22.7	0.2	4.8	-0.5	3.6
Smoking Status	0.6	1.4	3.8	-0.6	1.9	0.6	1.0
Allergy or Eczema	0.5	1.2	1.9	0.3	-1.3	-1.0	-1.4
Cardiovascular Disease	1.1	3.6	11.5	-0.8	3.4	1.0	1.3
Hypothyroidism (self reported)	5.6	12.8	21.7	-4.7	0.1	3.9	3.7
Respiratory disease	0.1	0.2	0.6	0.4	-0.3	-0.8	0.3
Type 2 Diabetes (T2D) (2018)	2.2	4.0	8.2	2.7	0.2	-2.9	-0.7
Lung FEV1/FVC ratio	11.4	58.0	121.0	-10.3	2.2	11.0	-0.1
Lung FVC	0.4	2.2	3.4	1.6	-1.0	-1.9	-1.4
Neuroticism	2.2	5.2	10.3	-3.2	0.2	2.9	1.4
Chronotype (morning person)	0.8	1.7	3.0	-1.2	-1.7	1.0	1.2
Hair Pigment	0.1	1.8	4.6	-1.3	0.7	0.2	2.1
Tanning	0.4	4.5	16.2	0.4	-4.0	-0.9	-1.0
Hand grip strength (left)	1.9	4.9	8.7	3.0	-0.0	-2.8	-1.7
Number of treatments/medications taken	1.6	2.8	5.8	-0.5	2.4	-0.6	2.2
Average weekly spirits intake	0.3	0.3	0.5	0.6	0.7	-0.5	0.4
Sensitivity / hurt feelings	2.5	4.4	8.4	-2.9	-0.7	2.9	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.8	-1.3	0.1	0.6	-0.1
Hearing difficulty/problems: Yes	5.0	7.6	15.8	3.6	-0.5	-4.0	-1.1
Relative age of first facial hair	0.5	1.0	3.5	0.0	-0.2	-0.5	1.9
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.7	1.1	-2.2	-1.2	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	1.0	-0.2	-1.0	-0.6
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	0.3	-0.3	-0.2	0.6
Systolic blood pressure, automated reading	1.8	5.1	10.4	0.2	3.2	-1.2	2.9
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.7	1.6	-1.5	-1.5	-0.7
Angina	0.3	0.4	0.6	0.7	-0.7	-0.1	-0.8
Medication for hormone replacement therapy	0.5	0.6	1.0	-0.6	-1.0	0.3	-0.9
Vitamin and mineral supplements	0.2	0.3	0.4	-0.4	0.3	0.6	0.6
Supplements: Zinc	0.1	0.1	0.2	-0.3	0.4	-0.1	0.3
Medication: Co-codamol	1.7	1.9	5.3	-0.6	2.3	-0.3	1.4
Medication: Metformin	4.2	6.0	12.7	3.3	-0.3	-3.6	-0.4
Diabetes (father)	1.1	1.3	2.5	1.5	-0.3	-1.6	0.6
Diabetes (mother)	2.4	3.1	4.4	1.4	2.1	-2.0	1.4
Severe depression (siblings)	0.3	0.4	1.0	0.5	-0.2	-0.5	-1.0
Pack years adult smoking proportion	0.7	1.1	2.3	1.5	0.3	-1.1	-0.9
Impedance of leg (right)	1.8	8.9	16.6	-4.0	1.0	4.1	1.3
Leg fat-free mass (left)	1.1	5.9	11.6	3.4	1.3	-3.0	-1.1
Trunk fat percentage	1.2	4.7	15.1	-0.0	3.9	0.0	1.9
Hand grip strength (right)	2.1	5.7	10.7	3.3	0.5	-3.3	-1.2
Townsend deprivation index at recruitment	1.1	1.6	2.2	-1.5	1.1	1.3	1.1
Current tobacco smoking	0.8	1.4	4.2	-0.6	2.1	0.3	0.9
Average weekly fortified wine intake	0.8	1.0	3.0	0.2	-1.7	0.1	-0.9
Maternal smoking around birth	0.1	0.2	0.5	-0.3	0.2	0.4	0.7
Fed-up feelings	2.6	4.7	8.1	-2.8	0.7	2.8	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	0.0	1.2	-0.7	0.1
Relative age voice broke	0.9	1.4	2.7	0.9	-1.0	-1.6	1.1
Taking other prescription medications	0.6	1.0	2.1	0.5	0.7	-1.0	1.4
Age when periods started (menarche)	0.3	0.8	2.3	0.8	0.5	-1.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.4	-0.6	0.6	0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.6	-2.6	0.9	2.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.4	-0.3	1.2	-0.1	0.6
Qualifications: CSEs or equivalent	0.9	1.2	2.2	-0.9	1.2	1.5	0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.1	-1.4	0.2	0.2
High blood pressure	1.6	4.3	11.1	0.9	3.3	-1.1	2.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-0.0	-1.5	-0.5	-1.1
Multivitamins +/- minerals	0.6	0.7	1.6	-0.8	1.3	0.8	-0.3
Stomach or abdominal pain in last month	1.2	1.5	4.0	-0.0	1.5	-0.1	2.0
Supplements: Glucosamine	0.1	0.1	0.3	0.4	-0.0	-0.2	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.4	1.0	0.5	-0.2
Medication: Atenolol	0.3	0.4	1.0	-0.2	1.0	0.6	0.2
Medication: Levothyroxine sodium	3.8	6.4	9.3	-3.1	0.2	2.8	2.9
Sitting height	0.4	3.1	7.2	2.7	0.3	-1.9	-1.2
Chronic bronchitis/emphysema (father)	2.4	2.8	5.3	0.0	2.3	-1.0	2.2
High blood pressure (mother)	0.2	0.2	0.8	0.3	0.9	-0.3	0.3
Body mass index (BMI)	0.7	2.9	7.0	1.1	2.6	-1.4	1.2
Impedance of leg (left)	1.5	7.1	12.3	-3.5	1.1	3.4	1.9
Leg predicted mass (left)	1.1	5.7	11.2	3.3	1.4	-2.9	-1.1
Trunk fat mass	1.1	4.6	14.2	1.0	3.8	-1.0	1.4
Waist circumference	0.9	3.2	9.2	0.4	3.0	-0.7	1.7
Number of incorrect matches in round	6.1	10.2	11.8	3.4	-3.4	-2.9	-3.0
Past tobacco smoking	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.2
Alcohol usually taken with meals	1.2	1.9	4.6	0.7	-2.1	-0.3	-1.6
Nervous feelings	0.4	0.8	1.5	-1.2	-1.0	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	-0.9	1.4	0.1	0.5
Hearing difficulty/problems with background noise	2.6	4.1	5.7	2.2	-2.4	-2.3	-1.0
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.5	0.8	0.7	0.2
Had menopause	1.9	2.4	3.4	1.8	-1.2	-1.6	-1.5
Had other major operations	1.7	2.0	5.9	1.0	-0.5	-1.0	-2.4
Forced vital capacity (FVC)	0.3	1.1	2.2	1.5	0.2	-0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.4	14.3	-3.8	0.2	3.2	1.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	5.4	-1.0	2.3	0.3	1.1
Qualifications: None of the above	1.5	3.3	4.7	-2.2	1.7	2.0	1.3
Financial difficulties in last 2 years	0.7	0.9	2.4	-0.9	1.6	0.5	-0.4
Mouth/teeth dental problems	2.9	4.5	7.6	2.6	-1.4	-2.8	-1.3
Heart attack	0.2	0.2	0.8	0.9	0.2	-0.2	0.0
Allergy	1.0	2.3	4.2	-1.6	1.4	2.0	0.9
Pain all over the body in last month	0.5	0.6	1.9	0.5	1.4	0.0	-0.2
Diabetes (self-reported)	1.6	2.4	5.3	2.1	0.3	-2.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.0	-0.5	1.1	0.5	-1.4
Medication: Ramipril	1.6	2.1	4.1	2.0	0.7	-1.9	-0.5
Medication: Simvastatin	0.5	0.7	1.4	-0.3	1.2	0.1	1.2
Fluid intelligence score	1.2	2.5	5.0	-2.2	0.4	2.2	0.3
Illnesses of siblings	0.6	0.8	1.2	-1.1	-0.2	1.0	-1.0
Neuroticism score	3.2	6.6	13.0	-3.6	0.2	3.4	1.5
Weight	0.9	4.5	7.0	2.4	2.7	-2.3	0.4
Impedance of arm (right)	1.3	6.0	13.8	-3.1	0.7	3.7	0.2
Arm fat percentage (right)	1.1	4.5	14.9	-0.2	3.9	0.2	1.7
Trunk fat-free mass	0.9	5.2	10.3	3.2	0.8	-2.9	-1.1
Hip circumference	0.2	1.0	3.4	-0.1	1.8	0.5	0.7
Time employed in main current job	1.9	2.2	4.8	1.6	-1.1	-2.2	0.5
Alcohol intake versus 10 years previously	0.8	1.2	1.7	-1.1	0.9	1.1	1.3
Father’s age at death	1.2	1.6	2.6	1.3	-1.6	-1.2	-0.8
Worrier / anxious feelings	1.0	1.9	3.0	-1.7	-1.1	1.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.8	0.3	2.4	-0.3	0.9
Falls in the last year	0.5	0.7	1.9	0.1	0.9	-0.4	1.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	1.0	0.2	-1.2	-0.1
Number of live births	6.3	8.9	17.2	-4.2	-0.7	4.1	1.2
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	10.1	-2.1	1.0	3.2	-1.2
Pulse rate	0.1	0.1	0.3	0.3	-0.1	-0.4	0.5
Happiness	0.3	0.4	1.4	-0.0	-0.2	-0.4	1.2
Noisy workplace	1.6	2.0	3.5	1.4	-1.9	-1.4	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.4	1.3	-0.8	-1.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	4.2	-1.5	0.6	1.3	2.0
Mouth/teeth dental problems: Dentures	4.5	7.6	9.7	-3.1	2.8	3.1	1.9
Asthma	0.4	0.8	1.2	0.9	-0.7	-1.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.5	-1.1	1.2	0.7	0.9
Medication: Cholesterol lowering	1.2	1.8	3.8	1.9	-0.2	-1.9	0.2
Depression (self-reported)	0.1	0.1	0.3	-0.1	-0.4	0.0	-0.6
Medication: Lansoprazole	2.8	3.2	4.9	-2.1	0.8	1.7	2.2
Prospective memory result	0.8	0.9	2.8	0.3	-1.7	-0.6	-0.7
Lung cancer (father)	0.5	0.6	2.0	0.2	-1.4	-0.7	0.1
Illnesses of mother	1.1	1.3	2.6	-1.6	-0.1	1.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	10.8	-2.2	1.3	3.3	-1.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.2	1.0	-0.0	1.1
Impedance of arm (left)	0.9	4.0	9.6	-2.5	0.3	3.1	0.1
Arm fat mass (right)	1.0	3.9	12.7	0.9	3.6	-0.9	1.1
Trunk predicted mass	0.9	4.9	9.8	3.1	0.7	-2.8	-1.2
Standing height	0.4	4.3	9.4	3.1	0.6	-2.1	-1.7
Length of working week for main job	1.0	1.1	1.6	1.1	-1.0	-1.3	-0.6
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.7	-0.7	0.5	-0.9
Breastfed as a baby	3.3	4.1	5.8	2.4	-1.7	-2.1	-1.8
Tense / ‘highly strung’	0.7	1.1	2.5	-1.6	-0.5	1.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	-1.5	0.9	0.7	1.2
Hair/balding pattern: Pattern 4	0.9	2.3	4.5	2.1	0.2	-2.1	-0.0
Birth weight of first child	1.6	2.9	4.6	1.7	-2.0	-2.1	0.4
Peak expiratory flow (PEF)	0.7	1.7	4.3	-1.0	0.3	2.1	-1.3
Pulse wave reflection index	0.8	1.0	1.7	-1.3	0.4	1.1	0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.3	-1.2	0.1	1.1
Loud music exposure frequency	0.4	0.4	0.9	-0.9	-0.6	0.4	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.0	1.0	0.7	-0.7	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.7	-0.4	0.4	0.3
Blood clot in the leg (DVT)	2.1	2.7	5.4	2.2	-0.0	-2.3	-0.7
Medication: Paracetamol	0.9	1.5	3.7	-0.9	1.9	0.7	1.0
Headache pain in last month	2.4	4.1	5.7	-2.4	1.9	2.2	1.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.8	-0.7	-2.0	0.7	-1.9
Glaucoma (self-reported)	1.7	2.0	3.8	1.7	1.0	-2.0	0.5
Gout (self-reported)	1.6	2.3	3.7	1.6	1.9	-1.7	-0.2
Hypothyroidism/myxoedema (self-reported)	5.8	11.4	17.6	-4.1	-0.0	3.4	4.2
Medication: Amlodipine	2.0	2.7	5.9	0.3	2.4	-0.5	2.2
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.3	0.5	-0.7	-1.5	-0.2
Birth weight	3.1	6.7	13.8	3.4	0.1	-3.7	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.8	0.1	-0.9	0.6
High blood pressure (siblings)	0.5	0.7	1.9	-0.0	1.0	-0.1	1.4
Forced vital capacity (FVC), Best measure	0.2	0.9	2.1	1.1	0.4	-0.3	-1.4
Body fat percentage	1.3	5.0	15.6	0.0	3.9	-0.2	2.1
Leg fat percentage (right)	1.3	4.9	13.6	-0.6	3.7	0.1	2.3
Arm fat-free mass (right)	1.2	6.0	12.0	3.5	1.0	-3.3	-0.7
Exposure to tobacco smoke outside home	0.2	0.2	0.7	-0.5	-0.0	0.0	-0.8
Comparative body size at age 10	3.0	8.4	15.9	4.0	1.5	-3.8	-1.0
Number of full brothers	0.6	0.7	1.8	-0.8	0.5	1.3	0.5
Worry too long after embarrassment	0.1	0.2	0.4	0.2	-0.7	-0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.8	-1.3	0.8	1.1	0.8
Wheeze or whistling in the chest in last year	0.8	1.4	4.0	-0.5	1.1	0.1	2.0
Number of children fathered	4.5	5.1	9.1	-2.7	1.9	3.0	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.5	-0.6	-0.7	1.0
Age at first live birth	6.8	12.1	13.8	3.7	-3.7	-3.6	-2.8
Pulse wave peak to peak time	0.6	0.7	1.4	0.4	-1.2	-0.1	-1.1
Health satisfaction	0.8	1.1	1.5	1.2	1.2	-1.2	-0.0
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.6	0.4	0.8	0.7
Qualifications: College or University degree	4.8	15.0	25.2	4.8	-3.0	-5.0	-1.7
Eye problems/disorders: None of the above	1.1	1.3	2.7	-1.2	-0.8	1.6	-0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.2	-1.1	-1.1	0.9	1.0
Emphysema/chronic bronchitis	0.4	0.4	0.6	0.7	-0.3	-0.8	0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.6	-0.2	-0.4	0.9	-1.3
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.2	0.1	-0.4	0.6
Medication: Blood pressure	2.0	3.6	5.9	1.3	2.4	-1.2	2.3
Angina (self-reported)	0.4	0.5	0.6	0.8	-0.8	-0.2	-0.8
Migraine (self-reported)	1.4	1.8	2.9	-1.6	-1.1	1.7	0.5
Medication: Ibuprofen	1.5	1.8	4.1	-0.7	2.0	0.1	1.6
Medication: Allopurinol	2.0	2.7	4.4	1.9	1.7	-2.1	-0.4
Medication: Omeprazole	0.8	0.9	1.5	-1.2	1.0	0.9	0.7
Medication: Seretide 50 evohaler	0.9	1.1	2.5	0.7	-1.6	-0.9	0.7
Mean time to correctly identify matches	1.3	2.6	9.0	0.2	-3.0	-0.2	-1.1
Heart disease (mother)	0.5	0.6	1.3	-0.0	0.9	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	10.7	-2.5	0.1	3.3	0.4
Whole body fat mass	1.1	4.6	13.6	1.0	3.7	-1.1	1.6
Leg fat mass (right)	1.1	4.3	12.9	0.9	3.6	-1.2	1.5
Arm predicted mass (right)	1.2	6.2	12.0	3.5	1.1	-3.3	-0.6
Pulse rate, automated reading	0.2	0.5	1.5	0.3	-1.2	-0.1	-0.6
Alcohol intake frequency.	0.4	1.0	1.5	-1.2	0.5	1.0	1.2
Comparative height size at age 10	0.3	1.7	3.4	1.4	1.8	-0.5	-1.0
Number of full sisters	2.7	3.3	6.4	-2.5	0.5	2.3	1.1
Suffer from ‘nerves’	1.1	1.8	3.8	-2.0	0.1	1.5	0.9
Overall health rating	0.8	1.6	4.3	0.2	2.1	-1.0	1.1
Chest pain or discomfort	0.5	0.7	1.2	1.1	-0.5	-0.9	-0.6
Had major operations	1.8	2.1	5.8	-1.4	-0.4	0.7	2.4
Age at last live birth	4.5	6.6	10.1	2.2	-3.2	-2.1	-2.6
Family relationship satisfaction	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.1
Leg pain on walking	0.7	0.9	1.4	1.1	-0.7	-1.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-0.4	1.3	0.3	0.8
Commuting to job workplace: Car/motor vehicle	2.4	2.8	7.0	-1.3	2.6	1.6	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	0.7	-0.8	-0.6	-0.5
Medication: Aspirin	0.3	0.3	1.2	0.2	-1.1	-0.4	0.2
Supplements: Vitamin C	0.8	1.0	2.8	-0.3	-1.7	-0.1	-1.0
Knee pain experienced in last month	0.6	0.9	2.3	0.3	-1.1	0.2	-1.5
Hypertension (Self-reported)	1.3	3.7	9.1	0.7	3.0	-0.8	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.2	-2.0	1.3	1.7	1.7
Illnesses of father: Heart disease	0.5	0.7	1.4	0.6	1.2	0.3	-1.0
Illnesses of siblings: Diabetes	0.5	0.6	1.6	0.5	1.3	-0.4	-0.6
Smoking status: Previous	0.0	0.1	0.1	0.3	-0.0	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	0.6	0.3	-0.1	-1.4
Whole body fat-free mass	1.1	6.1	12.3	3.5	1.0	-3.1	-1.2
Leg fat-free mass (right)	1.4	7.3	14.7	3.8	1.1	-3.4	-1.2
Arm fat percentage (left)	1.0	4.1	13.4	0.2	3.7	-0.2	1.7
Average weekly red wine intake	1.1	1.6	3.0	1.7	-0.6	-1.6	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.3	0.5	-1.1	-0.1	-1.8
Mood swings	3.8	7.0	12.8	-3.4	1.4	3.6	1.3
Loneliness, isolation	0.4	0.6	0.7	-0.7	0.7	0.8	0.9
Long-standing illness, disability or infirmity	0.6	0.9	2.4	0.9	0.0	-1.6	0.6
Ever had bowel cancer screening	1.4	1.6	6.0	-0.4	-0.3	-0.3	2.5
Diabetes diagnosed by doctor	1.8	3.0	6.2	2.4	-0.3	-2.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	6.3	-2.1	-0.2	2.5	0.1
Friendships satisfaction	0.7	0.9	1.6	-1.3	0.3	1.1	0.8
Qualifications: nursing, teaching	2.2	3.4	8.2	1.3	-2.9	-1.7	-0.9
Commuting to job workplace: Walk	2.0	2.1	3.9	1.5	-1.5	-2.0	0.2
Eye problems/disorders: Cataract	0.7	0.8	1.7	1.1	-0.0	-1.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.1	-1.2	0.9	1.1	1.8
Medication for cholesterol	1.9	2.9	4.2	1.9	-2.0	-1.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.3	-0.5	-0.2	0.7
Back pain experienced in last month	3.1	4.5	8.8	-2.9	-0.7	3.0	0.4
Mineral and other dietary supplements	0.2	0.2	0.6	0.4	0.8	-0.0	0.2
Breast cancer (self-reported)	0.5	0.6	1.6	0.9	-0.1	-0.4	-1.3
Asthma (self-reported)	0.4	0.9	1.5	1.0	-0.7	-1.2	-0.8
Osteoporosis (self-reported)	0.8	1.0	3.3	0.3	-0.1	-0.7	1.8
Osteoarthritis (self-reported)	2.1	2.7	7.4	1.8	0.0	-2.7	0.4
Medication: Aspirin	0.2	0.3	0.9	0.3	-0.9	-0.4	-0.1
Medication: Gliclazide	1.7	1.9	2.5	1.2	1.6	-1.5	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.0	-0.9	-0.9	1.0	0.0
Smoking status: Current	0.7	1.2	3.3	-0.7	1.8	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.2	14.5	-3.1	0.5	3.8	-0.7
Whole body water mass	1.1	6.1	12.0	3.5	1.0	-3.1	-1.2
Leg predicted mass (right)	1.4	7.3	14.7	3.8	1.0	-3.4	-1.3
Arm fat mass (left)	1.0	4.0	12.1	1.2	3.5	-1.2	1.1
Number of self-reported non-cancer illnesses	0.6	1.1	2.2	0.3	0.7	-1.3	1.5
Average weekly champagne plus white wine intake	1.1	1.5	3.5	0.8	-1.9	-0.4	-1.3
Miserableness	3.7	6.4	9.8	-3.1	1.2	2.4	2.9
Guilty feelings	0.6	0.9	3.1	-0.6	-0.5	-0.1	1.8
Wears glasses or contact lenses	1.0	1.1	1.6	1.1	-1.0	-1.3	-0.8
Ever taken oral contraceptive pill	0.5	0.5	1.0	-0.7	1.0	0.7	0.2
Hearing aid user	2.4	2.8	5.3	-0.5	-1.8	1.5	-2.3
Mother’s age at death	3.1	3.9	4.5	2.1	-1.9	-2.0	-1.9
Financial situation satisfaction	0.4	0.5	1.4	-0.4	-1.2	0.0	-0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	-1.1	-0.5	0.5	0.4
Commuting to job workplace: Public transport	0.8	0.9	1.3	1.0	-1.1	-1.1	0.1
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.7	0.5	-0.7	-0.3
Medication: Blood pressure	2.3	4.3	9.3	-1.1	3.0	0.7	2.5
Pain type(s) experienced in last month: Hip pain	2.9	3.7	6.6	-2.1	1.4	2.6	1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	-0.1	-1.4	0.0	-1.2
High cholesterol (Self-reported)	0.8	1.4	4.3	0.6	2.1	-0.7	0.7
Medication: Bendroflumethiazide	1.5	2.4	6.9	-1.0	1.2	0.2	2.6
Medication: Paracetamol	1.6	2.5	2.9	-1.7	1.6	1.3	1.7
Medication: Lisinopril	1.7	2.2	4.8	-0.3	2.0	0.0	2.2
Medication: Atorvastatin	0.8	1.0	1.8	1.4	0.5	-1.3	0.3
Illnesses of father: High blood pressure	0.6	0.8	1.5	-1.2	0.1	1.2	0.4
Alcohol drinker status: Never	1.0	1.2	3.2	1.1	0.8	-1.8	-0.1
Ever smoked	0.3	0.6	1.3	-0.9	0.2	1.1	0.4
Basal metabolic rate	1.0	5.4	10.0	3.2	1.7	-2.9	-0.7
Leg fat percentage (left)	1.5	5.6	14.5	-0.1	3.8	-0.5	2.8
Arm fat-free mass (left)	0.8	4.1	8.1	2.8	1.2	-2.5	-1.0
Number of operations (self-reported)	2.3	3.4	6.1	-2.2	-0.9	1.4	2.5
Average weekly beer plus cider intake	0.8	1.2	4.7	0.0	2.2	-0.3	-0.3
Irritability	2.0	3.4	6.4	-2.0	1.6	2.5	0.8
Risk taking	4.8	7.1	10.7	-3.3	2.3	2.8	2.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-1.3	-0.5	1.0	-0.1
Fractured/broken bones in last 5 years	0.7	1.0	2.4	0.3	-0.9	-0.6	1.6
Age started oral contraceptive pill	2.3	2.9	5.3	1.8	-1.8	-2.3	-0.1
Diastolic blood pressure, automated reading	0.7	2.0	4.5	0.9	2.1	-1.4	0.9
Ever depressed for a whole week	0.5	0.6	1.7	-0.1	1.3	0.3	-0.8
Unable to work because of sickness or disability	1.3	1.7	2.5	1.6	0.6	-1.6	-1.3
Commuting to job workplace: Cycle	2.1	2.5	5.3	1.4	-2.3	-1.7	-0.3
Myopia	1.4	2.1	3.7	1.9	0.2	-1.9	-1.0
Vascular/heart problems diagnosed by doctor	1.5	4.2	9.1	-0.4	-3.0	0.7	-2.7
Cholesterol lowering medication	0.8	1.2	3.8	-0.2	1.9	0.4	0.9
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.4	0.6	0.1	0.4
Pain experienced in last month	1.3	2.1	4.2	1.7	-1.2	-2.0	-0.2
Supplements: Calcium	0.2	0.2	0.3	0.5	-0.3	-0.6	-0.4
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	0.9	-0.1	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	1.1	-0.1	-0.5	-0.0
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	6.2	2.3	0.0	-2.5	-1.0
Heart disease (siblings)	4.9	6.0	13.0	3.6	-1.4	-2.9	-0.9
Alcohol drinker status: Previous	0.2	0.3	0.9	-0.1	-0.9	0.2	-0.4
Pack years of smoking	0.7	1.1	2.5	1.6	0.1	-1.1	-0.7
Impedance of whole body	1.4	7.3	15.5	-3.5	0.8	3.9	0.8
Leg fat mass (left)	1.3	4.9	13.0	1.3	3.6	-1.6	1.6
Arm predicted mass (left)	0.8	4.3	8.2	2.9	1.3	-2.6	-0.9