TWAS hub - ABTB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.461	0.1080	2.8e-03	-0.009	NA	-0.003	NA	-0.010	6.9e-01	NA	4.0e-01	NA	9.9e-01
2	METSIM	Adipose	0.105	0.0293	6.2e-07	0.082	0.057	0.074	0.070	0.077	2.5e-12	6.8e-09	2.8e-11	1.1e-10	1.2e-11
3	YFS	Blood	0.258	0.0340	0.0e+00	0.149	0.175	0.184	0.159	0.178	2.9e-46	7.3e-55	6.7e-58	1.6e-49	9.4e-56

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ever used hormone-replacement therapy (HRT)	8.7	11.1	17.8	-0.5	-3.9	-4.2
Illnesses of mother	6.8	8.4	13.4	1.2	3.2	3.7
Respiratory disease	6.3	14.1	24.5	-1.4	-4.0	-4.9
Number of treatments/medications taken	5.7	10.2	14.4	-1.5	-3.8	-3.8
Supplements: Calcium	5.7	6.3	8.5	-1.6	-2.9	-2.8
Medication for hormone replacement therapy	5.2	5.8	10.3	0.1	-2.6	-3.2
Asthma	5.0	9.8	15.5	-0.8	-3.7	-3.9
Long-standing illness, disability or infirmity	4.7	7.2	10.2	-1.7	-2.9	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	4.6	5.4	8.6	-0.2	-2.9	-2.8
Asthma (self-reported)	4.6	9.2	14.4	-0.7	-3.6	-3.8
Lung FEV1/FVC ratio	4.4	22.2	30.5	2.7	5.4	5.5
Wheeze or whistling in the chest in last year	4.4	7.8	12.1	-1.3	-3.1	-3.5
Breastfed as a baby	4.0	5.0	8.5	0.5	-2.9	-2.5
Birth weight	4.0	8.7	13.2	1.6	3.2	3.6
Heart disease (mother)	3.7	4.5	9.2	-1.0	-1.9	-3.0
Eye problems/disorders: Glaucoma	3.7	4.4	7.6	0.6	2.8	2.3
Wears glasses or contact lenses	3.6	4.1	6.4	-0.2	-2.5	-2.4
HbA1C	3.5	3.9	7.4	-0.8	-1.9	-2.7
Medication: Ibuprofen	3.5	4.2	6.4	-0.1	-2.5	-2.5
Number of self-reported non-cancer illnesses	3.3	5.7	8.0	-1.6	-2.6	-2.8
Ever taken oral contraceptive pill	3.3	3.6	4.3	1.6	-2.0	-2.1
Medication: Cholesterol lowering	3.2	5.1	8.3	-0.3	-2.9	-2.6
Glaucoma (self-reported)	3.2	3.8	6.6	0.3	2.6	2.2
Exposure to tobacco smoke outside home	3.2	4.2	4.7	-2.2	-2.1	-1.9
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	9.0	1.1	3.0	2.3
Medication: Atorvastatin	3.0	3.7	5.8	-0.9	-2.4	-2.1
Waist Hip Ratio (WHR)	2.9	13.0	20.8	-0.0	4.6	4.3
Vitamin and mineral supplements	2.9	3.9	5.5	-1.4	2.4	2.0
Taking other prescription medications	2.9	4.4	5.9	-2.4	-1.8	-2.0
Average weekly red wine intake	2.9	4.3	7.6	1.9	-2.8	-1.3
Risk taking	2.8	4.0	8.2	0.4	-1.9	-2.9
Shortness of breath walking on level ground	2.7	3.2	5.2	0.8	1.9	2.3
Mineral and other dietary supplements	2.7	3.7	6.4	-0.9	2.0	2.5
Medication: Seretide 50 evohaler	2.5	2.9	5.0	-0.0	-1.9	-2.2
Diastolic blood pressure, automated reading	2.5	7.7	10.5	-1.9	-3.2	-3.0
Multivitamins +/- minerals	2.3	3.0	5.4	0.7	-2.3	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	6.8	2.6	2.0	1.8
Osteoporosis (self-reported)	2.3	2.9	4.7	-0.7	-1.8	-2.2
Severe depression (siblings)	2.2	2.5	3.7	-0.6	-1.8	-1.9
Osteoarthritis (self-reported)	2.2	2.9	4.1	-2.0	-1.1	-1.8
Average weekly beer plus cider intake	2.2	3.1	4.8	-2.2	-0.1	-2.2
Supplements: Glucosamine	2.1	2.8	6.6	-0.0	-1.3	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.2	0.2	-2.3	-2.1
Smoking status: Previous	2.0	3.0	5.1	2.3	-1.6	-1.2
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.3	1.4	-1.8	-1.6
Mean Putamen Volume	1.9	2.2	2.6	1.4	-1.4	-1.6
Current tobacco smoking	1.9	3.1	6.1	-2.5	1.8	0.2
Medication for cholesterol	1.9	2.9	5.9	0.7	2.4	1.6
Medication: Lisinopril	1.9	2.4	5.9	0.4	-2.4	-1.1
Medication: Ramipril	1.8	2.3	5.0	-2.2	-0.6	-1.3
Illnesses of siblings	1.8	2.6	5.1	0.4	2.3	1.6
Gout (self-reported)	1.8	2.4	6.6	-2.6	0.8	0.1
Angina (self-reported)	1.8	2.3	4.5	0.6	-2.1	-1.4
Had major operations	1.8	2.1	2.6	-1.6	-1.5	-1.2
Lung FVC	1.7	8.6	9.1	3.0	-2.8	-2.9
Systolic blood pressure, automated reading	1.7	4.8	11.3	-3.4	-1.5	-1.0
Angina	1.7	2.3	4.0	0.7	-2.0	-1.5
Serious illness, injury or assault to yourself	1.7	2.0	3.7	-1.4	-1.9	-0.6
Alcohol usually taken with meals	1.7	2.7	5.3	2.3	-1.7	-0.1
Alcohol drinker status: Never	1.7	2.1	2.4	-1.4	1.5	1.4
Number of operations (self-reported)	1.7	2.5	2.9	-1.4	-1.7	-1.6
Heart disease (siblings)	1.7	2.1	2.2	-1.5	-1.5	-1.4
Bipolar Disorder (2011)	1.6	1.6	2.9	-0.4	1.3	1.7
Lupus	1.6	2.5	4.4	-0.7	1.6	2.1
Waist circumference	1.6	5.9	9.9	-0.7	2.7	3.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.3	-1.2	-0.7	-2.1
Hair/balding pattern: Pattern 3	1.6	2.4	4.3	-0.6	-2.1	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.7	-0.1	-1.6	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	13.3	3.6	0.9	1.1
Smoking status: Current	1.6	2.5	4.9	-2.2	1.6	0.1
Average weekly champagne plus white wine intake	1.6	2.2	4.5	2.1	-0.7	-1.3
Guilty feelings	1.6	2.4	5.9	0.4	1.0	2.4
Ever depressed for a whole week	1.6	2.0	3.7	-1.2	-1.9	-0.8
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.2	-0.4	-1.8	-1.2
High blood pressure (mother)	1.4	1.9	2.5	-1.3	-1.2	-1.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	11.4	3.4	1.1	1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.6	0.6	1.6	1.6
Number of children fathered	1.4	1.6	2.4	1.5	1.2	1.0
Leg pain on walking	1.4	1.8	2.8	0.4	1.7	1.5
Supplements: Vitamin C	1.4	1.7	1.9	1.2	-1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	8.8	3.0	-0.2	-0.2
Medication: Blood pressure	1.4	2.6	5.4	-1.4	-2.3	-0.8
Average weekly spirits intake	1.3	1.6	2.3	-0.8	1.3	1.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	1.9	-1.1	-1.0	-1.4
Allergy	1.3	3.0	5.1	0.8	1.8	2.3
Pulse wave reflection index	1.3	1.6	3.8	0.6	-1.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.8	0.6	1.9	1.5
Ever smoked	1.3	2.2	3.2	0.7	-1.7	-1.8
Forced vital capacity (FVC)	1.2	4.7	13.9	3.7	-0.3	-0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.5	0.1	-2.1	-1.8
Birth weight of first child	1.2	2.3	2.8	1.7	1.2	1.6
Chest pain or discomfort	1.2	1.7	2.6	-1.5	-0.4	-1.6
Neuroticism (2016)	1.1	1.7	3.2	-1.3	0.1	1.8
Systolic Blood Pressure	1.1	5.7	12.1	-3.5	-1.4	-1.7
Mouth/teeth dental problems	1.1	1.7	2.0	-1.1	-1.3	-1.4
Falls in the last year	1.1	1.5	2.2	-1.5	1.2	0.9
Peak expiratory flow (PEF)	1.1	2.5	4.7	2.2	1.5	0.6
High blood pressure (siblings)	1.1	1.6	3.0	-0.4	-1.7	-1.4
Forced vital capacity (FVC), Best measure	1.1	3.9	11.6	3.4	-0.3	-0.2
Commuting to job workplace: Walk	1.1	1.2	1.7	1.3	-1.0	-0.9
Eye problems/disorders: Cataract	1.1	1.2	2.0	0.7	-1.4	-1.1
Vascular/heart problems diagnosed by doctor	1.1	2.9	4.2	2.1	2.0	0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.9	0.6	-1.7	-0.9
Medication: Co-codamol	1.0	1.1	1.5	-0.9	-1.1	-1.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.0	-1.0	-1.4	-0.9
Heart attack	1.0	1.3	2.7	0.6	-1.7	-0.9
Time employed in main current job	1.0	1.2	1.5	1.0	-1.2	-1.1
Depression (self-reported)	1.0	1.1	1.3	-1.1	-1.2	-0.9
Hair/balding pattern: Pattern 4	1.0	2.5	3.7	1.3	-1.9	-1.5
Headache pain in last month	1.0	1.7	3.1	0.6	-1.8	-1.3
Loneliness, isolation	1.0	1.3	2.0	-1.4	-1.4	0.0
Breast cancer (self-reported)	1.0	1.2	1.7	0.9	1.3	1.1
Medication: Bendroflumethiazide	1.0	1.5	4.2	-2.0	-0.5	0.3
Myopia	1.0	1.4	2.2	-0.6	-1.3	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.3	1.8	0.6	0.2
Alcohol drinker status: Previous	1.0	1.1	2.7	-1.6	-0.4	-0.7
Sensitivity / hurt feelings	0.9	1.5	2.3	-1.5	-1.5	0.1
Diabetes (mother)	0.9	1.1	2.6	0.6	-0.7	-1.6
Stomach or abdominal pain in last month	0.9	1.1	2.1	-0.6	-0.9	-1.4
Had other major operations	0.9	1.1	1.9	-0.6	-1.4	-1.1
Standing height	0.9	8.7	16.0	4.0	2.1	2.4
Qualifications: College or University degree	0.9	3.0	4.8	2.2	-1.5	-1.3
Hypertension (Self-reported)	0.9	2.4	4.7	-2.2	-1.5	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.7	1.2	-1.3	0.0
Illnesses of father: High blood pressure	0.9	1.1	1.9	0.1	-1.2	-1.4
Age started oral contraceptive pill	0.9	1.1	2.0	-0.2	-1.4	-1.2
Schizophrenia (2018)	0.8	1.6	2.5	0.5	-1.6	-1.5
Worry (Nagel 2018)	0.8	1.6	3.2	-1.8	0.7	1.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	-0.1	-1.6	-0.5
Supplements: Zinc	0.8	0.9	2.0	0.5	-0.7	-1.4
High blood pressure	0.8	2.3	5.1	-2.3	-1.3	0.1
Past tobacco smoking	0.8	1.4	1.9	-1.4	1.1	1.1
Father’s age at death	0.8	1.1	3.3	1.8	-0.1	0.2
Medication: Amlodipine	0.8	1.2	2.2	-1.0	-1.5	-0.7
Medication: Blood pressure	0.8	1.4	2.0	-1.2	-1.4	-1.0
Medication: Allopurinol	0.8	1.0	2.9	-1.7	0.3	-0.3
Miserableness	0.8	1.4	3.8	0.1	-2.0	-0.7
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	-1.6	-0.2	-0.3
HDL Cholesterol	0.7	1.2	1.7	0.6	-1.3	-1.2
Schizophrenia (2014)	0.7	1.5	2.6	-0.2	-1.6	-1.4
Blood Eosinophil Count	0.7	5.2	10.0	-0.2	-2.4	-3.2
Allergy or Eczema	0.7	1.8	3.3	-1.8	-1.0	-1.0
Chronotype (morning person)	0.7	1.6	2.4	1.1	-1.6	-1.0
Age when periods started (menarche)	0.7	1.7	4.0	2.0	0.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.2	0.5	-1.1	-0.9
Medication: Levothyroxine sodium	0.7	1.1	3.2	-1.8	-0.1	0.2
Worrier / anxious feelings	0.7	1.4	3.5	-1.9	0.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	-1.4	0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.5	-0.6	-1.6	-0.3
Emphysema/chronic bronchitis	0.7	0.8	2.2	-1.5	-0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.2	0.4	-1.1	-0.9
Mother’s age at death	0.7	0.9	1.8	-1.3	0.9	-0.2
Commuting to job workplace: Public transport	0.7	0.9	1.4	0.9	0.6	1.2
Irritability	0.7	1.2	2.0	-0.1	-1.4	-1.3
Bipolar Disorder (2018)	0.6	1.0	2.2	-0.4	0.8	1.5
Blood Red Count	0.6	5.8	8.6	0.8	2.9	2.9
Cardiovascular Disease	0.6	1.8	2.2	-1.5	-1.1	-1.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	-1.1	-1.0	-0.1
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	0.4	1.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.8	1.7	-0.1	-1.0
Pain all over the body in last month	0.6	0.6	1.3	-0.5	-1.2	-0.5
Number of live births	0.6	0.9	1.3	1.1	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.2	1.1	-1.1	-0.3
Overall health rating	0.6	1.2	2.9	-1.7	-0.8	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.9	-1.0	-0.5	-1.0
Illnesses of siblings: Diabetes	0.6	0.7	1.7	1.3	-0.4	0.4
Ovarian Cancer	0.5	0.7	1.5	1.2	-0.6	-0.1
Prostate Cancer	0.5	0.8	1.9	0.6	0.1	1.4
LDL Cholesterol	0.5	0.8	2.3	-1.5	-0.2	-0.3
Primary Biliary Cirrhosis	0.5	0.6	1.6	-0.1	0.6	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	-1.0	0.6	0.5
Maternal smoking around birth	0.5	0.7	1.3	-0.9	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.5	1.6	-0.2	-0.8
Sitting height	0.5	3.7	11.0	3.3	-0.1	-0.0
Had menopause	0.5	0.6	1.1	-1.1	-0.8	-0.3
Arm fat percentage (right)	0.5	2.0	2.9	-1.7	1.4	1.1
Trunk fat-free mass	0.5	3.1	3.8	1.8	1.5	2.0
Prospective memory result	0.5	0.6	1.2	0.5	-0.5	-1.1
Arm fat mass (right)	0.5	1.9	2.8	-0.6	1.7	1.6
Trunk predicted mass	0.5	3.1	4.0	1.7	1.6	2.0
Loud music exposure frequency	0.5	0.5	1.4	1.2	0.3	0.3
Blood clot in the leg (DVT)	0.5	0.6	1.7	1.3	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.2	-1.1	0.8	1.1
Eye problems/disorders: None of the above	0.5	0.6	1.5	0.3	-0.2	-1.2
Alcohol intake frequency.	0.5	1.2	2.1	-0.2	1.2	1.5
Suffer from ‘nerves’	0.5	0.9	1.7	-1.3	0.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	1.3	-0.1	-0.1
Mood swings	0.5	1.0	2.2	-0.5	-1.5	-0.6
Ever had bowel cancer screening	0.5	0.6	0.7	0.6	-0.8	-0.9
Diabetes diagnosed by doctor	0.5	0.7	1.8	1.3	-0.5	-0.4
Friendships satisfaction	0.5	0.7	1.3	0.4	0.7	1.1
Back pain experienced in last month	0.5	0.8	1.4	-0.3	-0.9	-1.2
Medication: Gliclazide	0.5	0.6	1.6	1.3	0.2	0.2
Whole body water mass	0.5	2.7	3.3	1.7	1.4	1.8
Arm fat mass (left)	0.5	2.0	2.9	-0.8	1.7	1.6
Unable to work because of sickness or disability	0.5	0.7	1.8	-0.3	-1.4	-0.3
Pain experienced in last month	0.5	0.9	2.4	1.5	0.3	0.4
Depressed Affect (Nagel 2018)	0.4	0.7	1.0	-1.0	-1.0	0.5
Neuroticism (Nagel 2018)	0.4	1.0	1.9	-1.4	-0.2	1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-1.3	0.0	-0.1
Crohns Disease (2017)	0.4	0.8	1.2	-0.3	-1.1	-1.0
Reaction Time	0.4	0.8	1.7	1.3	0.8	0.3
Height	0.4	8.0	15.8	4.0	1.6	2.3
Neuroticism	0.4	0.9	1.9	-0.8	-0.5	1.4
Hearing difficulty/problems: Yes	0.4	0.7	1.8	1.3	-0.4	-0.0
Relative age of first facial hair	0.4	0.7	1.0	-0.8	1.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	-0.5	0.1	1.1
Leg fat-free mass (left)	0.4	1.9	2.6	0.8	1.5	1.6
Average weekly fortified wine intake	0.4	0.4	0.9	-0.3	-0.9	-0.6
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-1.1	-0.6	0.1
Leg predicted mass (left)	0.4	2.1	3.0	0.9	1.6	1.7
Trunk fat mass	0.4	1.8	2.9	0.2	1.7	1.6
Fluid intelligence score	0.4	0.9	1.1	0.7	1.1	1.0
Neuroticism score	0.4	0.9	1.4	-1.2	-0.8	0.7
Weight	0.4	1.9	3.0	0.6	1.5	1.7
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	-1.3	-0.3	0.3
Medication: Paracetamol	0.4	0.6	1.0	-0.7	1.0	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.7	0.9	-0.7	-0.6
Arm fat-free mass (right)	0.4	2.2	3.2	1.8	0.9	1.6
Neck or shoulder pain in last month	0.4	0.5	0.9	0.8	1.0	-0.1
Mean time to correctly identify matches	0.4	0.9	2.0	1.4	0.7	-0.1
Whole body fat mass	0.4	1.8	2.9	-0.3	1.7	1.6
Arm predicted mass (right)	0.4	1.9	2.5	1.6	0.9	1.5
Comparative height size at age 10	0.4	2.3	3.4	1.8	1.3	1.4
Number of full sisters	0.4	0.5	1.2	0.4	-0.3	1.1
Age at last live birth	0.4	0.6	1.4	1.2	0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.0	0.7	1.0
Illnesses of father: Heart disease	0.4	0.6	1.4	-0.0	-0.7	-1.2
Whole body fat-free mass	0.4	2.4	3.0	1.6	1.3	1.7
Arm fat percentage (left)	0.4	1.5	1.8	-1.4	1.3	1.0
Qualifications: nursing, teaching	0.4	0.6	1.2	0.1	0.7	-1.1
Basal metabolic rate	0.4	2.4	3.4	1.3	1.5	1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	0.0	0.6	1.0
Depression (Nagel 2018)	0.3	0.5	0.9	-1.0	-0.6	0.4
Schizophrenia vs Biploar Disorder	0.3	0.5	1.0	-0.6	0.1	-1.0
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.5	-0.7	-0.4
Triglycerides	0.3	0.5	1.2	-1.1	0.3	0.4
Blood White Count	0.3	2.0	4.3	-2.1	1.3	-0.3
Heel T-Score	0.3	2.1	5.1	2.3	-0.7	-0.8
BMI	0.3	1.9	3.2	-1.8	0.6	1.4
Smoking Status	0.3	0.6	1.3	-0.6	-0.4	-1.1
Hair Pigment	0.3	7.9	12.3	-1.6	-2.9	-3.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.8	-0.2	0.8
Impedance of leg (right)	0.3	1.4	2.4	-0.1	1.6	1.3
Trunk fat percentage	0.3	1.3	2.1	-0.4	1.5	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.8	-0.8	-0.8	-0.9
Body mass index (BMI)	0.3	1.1	1.7	-1.3	0.8	1.0
Nervous feelings	0.3	0.5	1.5	0.3	0.1	1.2
Financial difficulties in last 2 years	0.3	0.4	0.9	-1.0	0.2	0.3
Diabetes (self-reported)	0.3	0.5	0.9	0.9	0.5	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.9	-0.5	-0.0
Body fat percentage	0.3	1.3	1.9	-0.8	1.4	1.1
Leg fat percentage (right)	0.3	1.1	1.3	-1.1	1.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	-0.2	-0.6	-0.8
Leg fat mass (right)	0.3	1.2	1.6	-0.7	1.2	1.2
Knee pain experienced in last month	0.3	0.5	0.9	-0.5	-0.5	-1.0
Leg fat-free mass (right)	0.3	1.4	1.6	1.3	1.1	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	1.0	0.2	0.3
Leg predicted mass (right)	0.3	1.6	1.9	1.4	1.1	1.3
Financial situation satisfaction	0.3	0.3	0.9	-0.2	-0.1	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.5	-0.6	-0.8
Medication: Paracetamol	0.3	0.5	0.9	0.2	0.9	0.7
Arm fat-free mass (left)	0.3	1.6	2.7	1.1	1.0	1.6
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.5	0.2	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.0	-0.7	-0.8
Pack years of smoking	0.3	0.4	0.6	0.6	-0.4	-0.8
Leg fat mass (left)	0.3	1.0	1.6	-0.4	1.2	1.3
Arm predicted mass (left)	0.3	1.6	2.4	1.2	0.9	1.6
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.3	-0.8	-0.7
Major Depression (MDD)	0.2	0.3	0.7	0.0	-0.8	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	0.9	0.3	0.4
Breast Cancer	0.2	0.5	0.6	0.8	-0.6	-0.8
Age at First Birth	0.2	0.3	0.7	0.0	0.5	0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.6	0.5	-0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.3	0.6	0.3	0.5
Crohns Disease (2012)	0.2	0.3	0.5	-0.5	-0.7	-0.2
Fasting Glucose	0.2	0.2	0.5	-0.2	-0.2	0.7
Rheumatoid Arthritis	0.2	0.3	0.5	-0.6	0.3	0.7
Ulcerative Colitis	0.2	0.3	0.5	0.3	0.7	0.4
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.0	0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.4	-0.4	0.6	0.7
Medication: Metformin	0.2	0.2	0.7	-0.1	0.1	0.8
Relative age voice broke	0.2	0.3	0.4	0.4	0.5	0.6
Medication: Atenolol	0.2	0.3	0.4	-0.3	-0.7	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.4	-0.5	0.6
Number of incorrect matches in round	0.2	0.4	0.6	-0.8	0.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.0	1.0	-0.3	0.0
Hip circumference	0.2	0.8	1.7	0.3	0.7	1.3
Happiness	0.2	0.2	0.3	-0.5	-0.6	-0.2
Medication: Lansoprazole	0.2	0.3	0.5	-0.7	-0.1	-0.5
Lung cancer (father)	0.2	0.2	0.5	-0.1	0.5	0.7
Impedance of arm (left)	0.2	0.8	2.1	-0.3	1.4	0.6
Length of working week for main job	0.2	0.2	0.7	0.9	0.0	-0.0
Tense / ‘highly strung’	0.2	0.3	0.4	-0.5	-0.6	-0.5
Number of full brothers	0.2	0.3	0.5	0.7	-0.6	0.1
Age at first live birth	0.2	0.3	0.9	0.3	-0.1	-0.9
Pulse wave peak to peak time	0.2	0.2	0.4	0.6	0.6	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.2	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	1.0	0.1	0.3
Migraine (self-reported)	0.2	0.2	0.5	0.2	-0.3	-0.7
Family relationship satisfaction	0.2	0.3	0.5	0.5	-0.7	-0.1
Medication: Aspirin	0.2	0.2	0.4	-0.1	-0.6	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.1	-0.7	-0.2
Ulcerative Colitis (UC)	0.1	0.3	0.6	-0.1	0.8	0.5
Blood Platelet Count	0.1	1.5	2.3	-1.3	0.7	-1.5
Tanning	0.1	1.6	2.8	0.3	-1.7	-1.4
Hand grip strength (left)	0.1	0.2	0.4	0.7	-0.2	-0.3
Diabetes (father)	0.1	0.2	0.4	0.3	-0.6	0.1
Pack years adult smoking proportion	0.1	0.2	0.4	0.4	-0.2	-0.6
Hand grip strength (right)	0.1	0.3	0.5	0.7	0.5	0.1
Fed-up feelings	0.1	0.1	0.4	0.1	-0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.4	-0.3	-0.1
Impedance of leg (left)	0.1	0.3	0.3	0.3	0.6	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	0.0	-0.3
Qualifications: None of the above	0.1	0.3	0.3	-0.5	-0.4	-0.6
Impedance of arm (right)	0.1	0.5	1.2	-0.5	1.1	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.7	-0.3	0.3
Pulse rate	0.1	0.2	0.5	-0.4	0.7	0.2
Noisy workplace	0.1	0.1	0.2	-0.3	-0.4	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.2	-0.4	0.1
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.7	-0.0	-0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	-0.1	-0.5
Comparative body size at age 10	0.1	0.3	0.5	0.7	-0.0	0.5
Worry too long after embarrassment	0.1	0.2	0.5	-0.7	-0.3	0.3
Medication: Omeprazole	0.1	0.1	0.1	0.1	0.2	0.4
Pulse rate, automated reading	0.1	0.3	0.8	-0.3	0.9	0.3
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	-0.2	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.4	0.1	-0.4
Hearing aid user	0.1	0.1	0.4	-0.2	-0.6	-0.0
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.8	-0.1	-0.2
Leg fat percentage (left)	0.1	0.5	0.6	-0.8	0.6	0.7
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.3	0.2	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.1	-0.3	-0.3
Cholesterol lowering medication	0.1	0.2	0.2	-0.4	0.5	0.2
Impedance of whole body	0.1	0.3	0.8	0.1	0.9	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	0.1	-0.3	-0.5
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	0.2	-0.1
Medication: Simvastatin	0.0	0.1	0.2	-0.4	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.0	0.2	-0.0
Health satisfaction	0.0	0.0	0.1	0.3	-0.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.3	0.2	-0.1

Hub : Genes

ABTB1

Models

Trait associations