[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:44,779,991-48,392,033

Best TWAS P=6.35e-18 · Best GWAS P=2.92e-18 conditioned to 0.0165

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	MUTYH	0.04	0.00	enet	23	0.00	8.5e-01	-6.88	8.6	6.4e-18	0.71	0.04	0.76	TRUE
53	GTEx	Whole Blood	RP1-18D14.7	0.15	0.13	enet	17	0.13	7.7e-12	6.12	-5.7	1.2e-08	-0.04	0.01	0.99	TRUE
62	YFS	Blood	ATPAF1	0.01	0.00	blup	362	0.00	2.3e-02	3.36	-5.6	2.1e-08	-0.12	0.28	0.02	TRUE
32	GTEx	Muscle Skeletal	RP11-767N6.7	0.06	0.06	lasso	3	0.04	6.6e-05	7.79	8.4	6.0e-17	0.78	0.18	0.77	FALSE
66	YFS	Blood	TMEM69	0.02	0.01	bslmm	294	0.01	2.1e-04	5.03	8.2	1.8e-16	0.69	0.16	0.63	FALSE
33	GTEx	Nerve Tibial	TESK2	0.07	0.00	lasso	13	0.00	3.5e-01	-6.88	-8.2	2.7e-16	-0.76	0.08	0.78	FALSE
35	GTEx	Nerve Tibial	IPP	0.07	0.04	enet	12	0.05	1.9e-04	7.69	8.1	5.8e-16	0.61	0.39	0.44	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	MMACHC	0.09	0.05	blup	41	0.06	2.5e-06	8.71	-8.1	6.1e-16	-0.93	0.01	0.99	FALSE
30	GTEx	Muscle Skeletal	GPBP1L1	0.03	0.02	enet	19	0.03	7.2e-04	-5.13	8.1	6.6e-16	0.65	0.27	0.56	FALSE
16	GTEx	Cells Transformed fibroblasts	MUTYH	0.20	0.10	enet	22	0.11	8.3e-09	-6.96	8.0	1.3e-15	0.66	0.46	0.54	FALSE
42	GTEx	Testis	PRDX1	0.22	0.00	enet	19	0.05	2.2e-03	7.72	-7.9	2.8e-15	-0.70	0.05	0.65	FALSE
23	GTEx	Esophagus Muscularis	MUTYH	0.08	0.04	enet	9	0.04	1.5e-03	-6.88	7.8	4.5e-15	0.81	0.03	0.94	FALSE
93	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM69	0.10	0.05	lasso	2	0.04	5.9e-04	7.83	7.8	4.9e-15	0.70	0.00	0.98	FALSE
56	METSIM	Adipose	MUTYH	0.07	0.04	blup	286	0.05	1.8e-07	-6.88	7.8	7.4e-15	0.86	0.11	0.89	FALSE
44	GTEx	Testis	GPBP1L1	0.07	0.06	enet	7	0.03	1.7e-02	7.69	7.7	1.3e-14	0.70	0.28	0.34	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MMACHC	0.10	0.11	lasso	2	0.11	6.6e-07	-7.21	-7.7	1.4e-14	-0.89	0.07	0.92	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	MMACHC	0.04	0.01	blup	274	0.02	1.4e-03	7.72	-7.6	2.1e-14	-0.82	0.02	0.98	FALSE
13	GTEx	Brain Caudate basal ganglia	MUTYH	0.19	0.05	enet	21	0.14	1.1e-04	7.75	7.6	2.6e-14	0.75	0.04	0.68	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	MUTYH	0.04	0.04	blup	282	0.03	3.7e-05	-6.88	-7.6	3.2e-14	-0.80	0.10	0.89	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	MMACHC	0.04	0.03	blup	41	0.03	3.0e-04	7.73	-7.5	4.4e-14	-0.93	0.02	0.88	FALSE
4	GTEx	Adipose Subcutaneous	GPBP1L1	0.05	0.05	lasso	4	0.05	8.7e-05	7.25	7.5	5.2e-14	0.63	0.64	0.25	FALSE
7	GTEx	Artery Aorta	MAST2	0.26	0.32	lasso	16	0.31	2.0e-17	7.42	7.4	1.5e-13	0.63	0.99	0.01	FALSE
20	GTEx	Colon Transverse	GPBP1L1	0.06	0.01	lasso	6	0.01	8.3e-02	-4.92	7.4	1.5e-13	0.61	0.16	0.58	FALSE
38	GTEx	Skin Sun Exposed Lower leg	RP11-767N6.2	0.05	0.01	enet	13	0.02	1.6e-02	-5.15	-7.4	1.6e-13	-0.58	0.63	0.11	FALSE
11	GTEx	Artery Tibial	GPBP1L1	0.04	0.04	enet	7	0.03	2.2e-03	-6.57	7.4	1.7e-13	0.63	0.37	0.54	FALSE
57	NTR	Blood	PIK3R3	0.01	0.02	lasso	2	0.02	4.5e-06	7.15	7.3	2.1e-13	0.63	0.24	0.76	FALSE
27	GTEx	Heart Left Ventricle	MAST2	0.21	0.08	lasso	7	0.10	5.5e-06	7.83	7.3	2.3e-13	0.71	0.10	0.90	FALSE
28	GTEx	Lung	MAST2	0.06	0.06	lasso	5	0.05	1.7e-04	7.06	7.2	4.7e-13	0.62	0.88	0.09	FALSE
49	GTEx	Thyroid	IPP	0.08	0.07	lasso	3	0.08	7.1e-07	7.18	7.2	4.7e-13	0.62	0.98	0.01	FALSE
39	GTEx	Stomach	MUTYH	0.08	0.02	lasso	4	0.02	4.1e-02	-6.88	7.2	4.8e-13	0.69	0.10	0.44	FALSE
2	GTEx	Adipose Subcutaneous	MAST2	0.09	0.09	lasso	4	0.08	2.6e-07	7.05	7.2	5.2e-13	0.63	0.98	0.01	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	MUTYH	0.37	0.09	enet	17	0.21	3.3e-21	-5.93	7.2	5.2e-13	0.67	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	MUTYH	0.16	0.03	enet	12	0.06	3.0e-07	-3.49	7.2	7.3e-13	0.57	0.00	1.00	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	MUTYH	0.53	0.08	enet	14	0.28	3.8e-27	-4.06	7.1	9.0e-13	0.68	0.06	0.94	FALSE
29	GTEx	Lung	GPBP1L1	0.04	0.02	enet	14	0.02	5.8e-03	-4.90	7.1	1.0e-12	0.57	0.27	0.57	FALSE
50	GTEx	Uterus	MAST2	0.30	0.28	lasso	2	0.18	2.0e-04	7.06	7.1	1.1e-12	0.61	0.45	0.35	FALSE
10	GTEx	Artery Tibial	MAST2	0.29	0.30	lasso	2	0.30	1.8e-23	7.06	7.1	1.6e-12	0.60	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	GPBP1L1	0.10	0.04	lasso	6	0.06	3.4e-04	7.42	7.0	1.9e-12	0.55	0.83	0.14	FALSE
22	GTEx	Esophagus Muscularis	MAST2	0.17	0.13	enet	30	0.11	3.8e-07	7.18	7.0	2.2e-12	0.60	0.99	0.01	FALSE
48	GTEx	Thyroid	GPBP1L1	0.05	0.06	enet	6	0.07	7.9e-06	-6.57	7.0	2.4e-12	0.57	0.68	0.30	FALSE
18	GTEx	Colon Sigmoid	MAST2	0.18	0.10	lasso	4	0.13	2.5e-05	7.06	7.0	2.6e-12	0.59	0.90	0.03	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMACHC	0.01	0.00	blup	41	0.01	5.4e-03	8.71	-7.0	3.7e-12	-0.90	0.01	0.71	FALSE
9	GTEx	Artery Coronary	MAST2	0.09	0.09	lasso	4	0.08	1.3e-03	7.49	6.9	4.1e-12	0.59	0.43	0.21	FALSE
55	METSIM	Adipose	MAST2	0.06	0.06	lasso	6	0.05	1.3e-08	7.06	6.9	4.7e-12	0.59	0.95	0.05	FALSE
87	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MMACHC	0.16	0.12	blup	41	0.12	2.1e-05	-4.18	-6.9	5.2e-12	-0.69	0.29	0.53	FALSE
54	METSIM	Adipose	CCDC17	0.03	0.02	blup	287	0.01	5.6e-03	7.21	6.9	6.0e-12	0.56	0.36	0.16	FALSE
19	GTEx	Colon Transverse	MAST2	0.18	0.09	lasso	7	0.07	4.5e-04	7.48	6.9	7.0e-12	0.57	0.70	0.10	FALSE
15	GTEx	Cells Transformed fibroblasts	MAST2	0.25	0.33	enet	16	0.30	1.0e-22	7.06	6.8	7.8e-12	0.61	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	MUTYH	0.37	0.13	enet	19	0.23	6.8e-26	-5.93	6.8	1.2e-11	0.67	0.00	1.00	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMACHC	0.07	0.05	enet	12	0.09	3.1e-09	7.72	-6.7	1.9e-11	-0.84	0.02	0.98	FALSE
52	GTEx	Whole Blood	TESK2	0.14	0.05	enet	23	0.11	5.6e-10	7.71	-6.6	3.5e-11	-0.77	0.31	0.69	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	TESK2	0.05	0.02	blup	82	0.04	3.4e-05	-3.97	-6.6	3.9e-11	-0.70	0.10	0.89	FALSE
34	GTEx	Nerve Tibial	MAST2	0.08	0.05	lasso	4	0.06	5.6e-05	7.06	6.6	4.1e-11	0.59	0.75	0.03	FALSE
8	GTEx	Artery Aorta	TMEM69	0.09	0.02	enet	9	0.03	6.4e-03	7.82	6.6	4.5e-11	0.69	0.38	0.40	FALSE
31	GTEx	Muscle Skeletal	IPP	0.15	0.01	enet	7	0.04	6.4e-05	-4.75	6.6	5.1e-11	0.34	0.44	0.07	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUTYH	0.14	0.00	blup	36	0.04	3.4e-05	-4.03	6.5	6.1e-11	0.64	0.07	0.51	FALSE
63	YFS	Blood	CCDC17	0.04	0.02	lasso	8	0.02	6.8e-08	-5.14	6.5	8.8e-11	0.47	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	TESK2	0.17	0.02	enet	17	0.04	1.6e-03	-5.29	-6.5	1.0e-10	-0.55	0.08	0.69	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	MUTYH	0.17	0.02	enet	12	0.11	1.1e-06	-4.00	6.4	1.6e-10	0.66	0.02	0.46	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MUTYH	0.11	0.03	blup	36	0.04	1.8e-04	-4.03	6.4	1.7e-10	0.64	0.05	0.23	FALSE
40	GTEx	Stomach	RP11-767N6.7	0.08	0.03	enet	16	0.05	1.3e-03	7.06	6.4	1.9e-10	0.50	0.34	0.16	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MUTYH	0.24	0.03	enet	14	0.15	3.2e-16	-5.93	6.3	2.7e-10	0.65	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC163P	0.07	0.05	blup	37	0.10	3.5e-11	-3.19	-6.3	2.7e-10	-0.85	0.19	0.81	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	MUTYH	0.20	0.05	blup	36	0.10	3.0e-19	-5.93	6.3	2.9e-10	0.62	0.00	1.00	FALSE
45	GTEx	Testis	IPP	0.05	0.06	enet	8	0.03	1.4e-02	-5.15	-6.3	3.2e-10	-0.47	0.19	0.44	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	GPBP1L1	0.11	0.06	lasso	3	0.06	1.6e-06	-5.14	6.1	8.6e-10	0.44	0.66	0.33	FALSE
21	GTEx	Esophagus Mucosa	GPBP1L1	0.04	0.02	lasso	3	0.02	1.5e-02	-5.14	6.1	9.9e-10	0.43	0.14	0.40	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPP	0.04	0.04	blup	47	0.04	1.4e-03	-4.38	6.1	1.2e-09	0.42	0.10	0.25	FALSE
25	GTEx	Heart Atrial Appendage	MAST2	0.22	0.07	lasso	15	0.12	5.3e-06	-3.56	6.1	1.4e-09	0.57	0.79	0.14	FALSE
41	GTEx	Testis	TESK2	0.15	0.01	lasso	3	0.04	8.4e-03	-3.97	-6.0	1.9e-09	-0.69	0.14	0.75	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPBP1L1	0.04	0.04	blup	50	0.04	2.9e-05	-5.14	6.0	2.0e-09	0.42	0.40	0.48	FALSE
51	GTEx	Uterus	UROD	0.19	-0.01	enet	15	0.00	3.3e-01	2.48	5.9	2.9e-09	0.54	0.06	0.26	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MUTYH	0.12	0.00	blup	36	0.04	1.2e-02	-3.88	5.9	3.5e-09	0.62	0.01	0.13	FALSE
5	GTEx	Adipose Subcutaneous	RP11-767N6.2	0.03	0.03	enet	6	0.04	3.0e-04	-4.24	-5.8	4.8e-09	-0.41	0.32	0.14	FALSE
26	GTEx	Heart Atrial Appendage	MMACHC	0.10	0.06	enet	11	0.10	3.3e-05	-5.32	-5.8	7.5e-09	-0.46	0.59	0.12	FALSE
72	The Cancer Genome Atlas	Glioblastoma Multiforme	MUTYH	0.16	0.10	blup	36	0.09	8.1e-04	-3.97	5.7	1.2e-08	0.53	0.14	0.09	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MUTYH	0.30	0.06	blup	36	0.12	1.8e-07	-3.96	5.7	1.3e-08	0.66	0.57	0.28	FALSE
64	YFS	Blood	IPP	0.10	0.11	lasso	15	0.12	4.6e-36	-4.95	5.6	1.7e-08	0.38	1.00	0.00	FALSE
37	GTEx	Skin Sun Exposed Lower leg	GPBP1L1	0.03	0.00	lasso	5	0.00	4.8e-01	-0.99	5.6	2.1e-08	0.55	0.14	0.15	FALSE
84	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MMACHC	0.07	0.02	blup	41	0.03	4.2e-03	7.75	-5.6	2.2e-08	-0.82	0.12	0.34	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	RPS15AP10	0.03	0.05	blup	283	0.04	8.0e-06	-5.32	-5.6	2.3e-08	-0.37	0.99	0.00	FALSE
86	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC163P	0.17	0.11	blup	37	0.14	4.4e-06	-3.16	-5.6	2.7e-08	-0.75	0.15	0.83	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	GPBP1L1	0.09	0.02	enet	11	0.02	3.5e-02	-5.01	5.5	3.1e-08	0.43	0.71	0.14	FALSE
91	The Cancer Genome Atlas	Soft Tissue Sarcoma	MUTYH	0.15	0.04	lasso	3	0.09	5.3e-06	-4.03	5.5	3.1e-08	0.54	0.77	0.10	FALSE
47	GTEx	Thyroid	MAST2	0.06	0.05	lasso	4	0.04	4.9e-04	-4.03	5.5	4.0e-08	0.40	0.80	0.02	FALSE
83	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MUTYH	0.17	0.01	blup	36	0.06	3.1e-07	-5.93	5.5	4.0e-08	0.47	0.00	0.93	FALSE
17	GTEx	Cells Transformed fibroblasts	TMEM69	0.10	0.07	enet	10	0.07	3.0e-06	-3.83	5.5	4.4e-08	0.61	0.24	0.75	FALSE
65	YFS	Blood	TAL1	0.03	0.02	bslmm	402	0.02	2.6e-06	6.09	-5.5	4.6e-08	-0.06	0.01	0.99	FALSE
46	GTEx	Testis	RP11-767N6.2	0.05	0.00	enet	14	0.01	1.1e-01	-5.15	-5.4	5.6e-08	-0.36	0.25	0.04	FALSE
12	GTEx	Artery Tibial	RP11-767N6.2	0.04	0.02	enet	5	0.04	6.9e-04	-3.96	-5.4	7.4e-08	-0.45	0.49	0.14	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	IPP	0.08	0.15	lasso	9	0.14	5.0e-18	-5.13	5.2	1.5e-07	0.36	1.00	0.00	FALSE
14	GTEx	Brain Putamen basal ganglia	RAD54L	0.30	0.04	enet	30	0.06	1.4e-02	2.83	5.2	2.2e-07	0.35	0.05	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TESK2	0.06	0.02	bslmm	327	0.04	2.3e-05	-4.01	-5.2	2.6e-07	-0.48	0.92	0.02	FALSE
43	GTEx	Testis	PIK3R3	0.08	0.05	enet	7	0.06	1.5e-03	-5.06	5.2	2.7e-07	0.32	0.56	0.03	FALSE
80	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MUTYH	0.25	0.03	blup	36	0.08	1.1e-04	-0.32	5.1	2.7e-07	0.57	0.00	0.81	FALSE
24	GTEx	Esophagus Muscularis	CCDC17	0.04	0.04	lasso	6	0.01	9.1e-02	-5.00	5.1	2.9e-07	0.33	0.37	0.28	FALSE