Hub : Genes

ATPAF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0260	2.8e-06	0.052	0.034	0.029	0.034	0.029	5.3e-07	4.9e-05	1.6e-04	0.00005	1.5e-04
2	GTEx	Cells Transformed fibroblasts	0.0630	0.0290	5.1e-03	0.001	NA	0.008	NA	0.002	2.5e-01	NA	7.7e-02	NA	2.1e-01
3	GTEx	Uterus	0.2480	0.1020	9.8e-03	0.020	NA	0.028	NA	0.035	1.3e-01	NA	9.0e-02	NA	6.6e-02
4	YFS	Blood	0.0116	0.0065	2.3e-02	0.005	0.003	-0.001	0.003	0.002	7.9e-03	2.3e-02	5.4e-01	0.02400	4.2e-02
5	TCGA	Prostate Adenocarcinoma	0.0371	0.0247	7.0e-04	0.047	0.033	0.041	NA	0.047	1.0e-05	2.0e-04	4.1e-05	NA	1.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	1.0	1.7	-1.0	-1.3	-0.8	-1.1	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	-0.5	-0.9	0.1	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.1	0.1	0.5	0.0	-0.1	-0.2	0.1	-0.7
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	0.6	0.4	-0.2	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.0	1.7	0.8	-1.2	0.2	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.4	0.8	-0.1	0.5	-0.6
Schizophrenia (2018)	0.1	0.1	0.6	0.1	-0.1	0.8	-0.2	-0.1
Schizophrenia vs Biploar Disorder	0.7	0.9	2.3	1.0	1.5	0.4	1.0	0.3
Worry (Nagel 2018)	0.1	0.3	0.9	-0.2	-0.4	1.0	0.1	0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	0.5	0.7	-1.0	-0.0	-0.8
Alzheimer’s Disease (in father)	1.3	1.4	3.0	-1.7	-1.0	0.2	-1.7	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	-0.2	-0.0	-1.4	-0.2	-1.3
Crohns Disease (2017)	0.1	0.3	1.3	-1.1	-0.2	0.1	-0.5	-0.2
Irritable Bowel Disease (IBD)	0.2	0.6	2.5	-1.6	0.3	0.3	-0.5	-0.0
Ulcerative Colitis (UC)	0.4	0.8	2.6	-1.6	0.3	0.8	-0.4	0.6
Major Depression (MDD)	0.5	0.7	1.8	-0.9	-0.3	0.5	-1.3	0.7
Reaction Time	0.7	1.4	3.5	-1.9	-0.5	0.9	-1.6	0.2
Verbal and Numeric Reasoning (VNR)	1.3	3.2	8.7	3.0	1.9	-1.6	0.6	-0.7
Breast Cancer	0.5	1.3	4.2	-2.0	-0.0	0.4	-1.2	0.8
Ovarian Cancer	0.2	0.3	0.4	0.6	0.6	-0.5	0.6	-0.6
Prostate Cancer	0.4	0.6	1.6	1.0	-0.1	-0.3	1.3	-0.5
Age at First Birth	0.4	0.6	1.3	-1.1	-1.0	0.2	-0.7	-0.1
Bipolar Disorder (2011)	0.5	0.5	1.1	-0.8	0.0	0.7	-1.1	0.5
Body Mass Index (BMI) (2010)	2.6	3.6	5.7	-1.8	-1.2	1.8	-2.4	2.0
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.4	0.2	0.2	-0.7	0.7
Crohns Disease (2012)	2.9	4.6	7.5	-2.4	-2.7	2.1	-0.6	2.2
Mean Putamen Volume	1.2	1.4	3.5	0.5	0.3	-1.7	0.4	-1.9
Fasting Glucose	0.3	0.3	1.0	-0.0	-1.0	-0.3	-0.6	-0.2
HbA1C	1.5	1.6	4.5	-1.2	-2.1	1.1	0.0	1.0
HDL Cholesterol	2.1	3.4	5.3	-2.0	-2.0	2.3	-0.9	1.9
LDL Cholesterol	0.2	0.3	0.7	0.2	-0.8	-0.5	-0.4	0.8
Lupus	0.3	0.5	1.0	-0.4	-0.5	0.9	-0.3	1.0
Neuroticism (2016)	1.3	1.9	3.8	-0.9	-1.3	1.3	-1.9	1.2
Primary Biliary Cirrhosis	0.2	0.4	1.6	-0.0	-1.3	0.1	0.4	-0.0
Rheumatoid Arthritis	1.2	1.6	2.2	1.5	-0.1	-1.4	1.3	-1.4
Schizophrenia (2014)	0.1	0.1	0.2	0.4	-0.5	0.0	-0.2	-0.5
Triglycerides	0.7	1.1	2.1	1.2	0.9	-1.4	0.8	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.1	-1.2	-0.3	-0.5	0.4
Ulcerative Colitis	2.6	3.8	5.8	-2.3	-1.6	2.4	-1.4	1.8
Blood Eosinophil Count	0.2	1.2	2.8	0.4	-0.6	1.3	1.1	1.7
Blood Platelet Count	0.3	3.4	6.9	-0.8	-1.4	2.1	-2.6	1.8
Blood Red Count	1.6	15.1	22.2	3.5	4.6	-3.3	4.7	-3.0
Blood White Count	0.1	0.6	1.6	-0.0	1.3	0.8	-0.3	1.0
Heel T-Score	1.3	10.6	14.8	3.2	2.4	-3.9	3.0	-3.6
BMI	0.1	0.6	1.1	1.1	1.0	-1.0	0.0	-0.1
Height	0.1	1.5	4.7	-0.6	-1.1	-0.5	2.2	-1.0
Waist Hip Ratio (WHR)	0.4	1.7	4.1	1.0	2.0	-1.6	-0.4	-1.1
Systolic Blood Pressure	0.2	1.0	2.5	0.9	-0.3	-0.9	0.7	-1.6
Smoking Status	0.4	0.9	1.8	0.4	-0.9	-1.0	-1.4	-0.7
Allergy or Eczema	0.7	1.8	3.1	-0.0	-1.7	1.7	0.1	1.8
Cardiovascular Disease	2.5	8.2	11.4	3.0	1.4	-3.2	3.0	-3.4
Hypothyroidism (self reported)	0.6	1.3	3.1	0.6	-1.8	0.6	1.6	0.4
Respiratory disease	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.8	-0.6	0.2	-0.0	0.3
Lung FEV1/FVC ratio	3.9	19.6	31.4	-4.1	-3.1	4.2	-5.6	4.8
Lung FVC	0.1	0.4	1.0	-1.0	-0.7	0.7	-0.1	0.3
Neuroticism	0.2	0.4	1.0	0.6	1.0	0.1	0.9	-0.2
Chronotype (morning person)	2.3	5.3	6.6	-2.4	-1.8	2.6	-2.2	2.4
Hair Pigment	0.0	0.4	1.0	-0.7	0.6	0.2	-1.0	0.1
Tanning	0.2	2.1	3.7	-1.9	-1.4	1.3	-1.4	1.1
Hand grip strength (left)	0.6	1.7	3.4	0.6	1.5	-1.1	1.0	-1.9
Number of treatments/medications taken	0.8	1.5	3.5	0.8	-0.4	-1.9	0.7	-1.6
Average weekly spirits intake	1.2	1.5	2.3	-0.5	-0.9	1.4	-1.4	1.5
Sensitivity / hurt feelings	0.1	0.2	0.6	0.6	0.8	-0.2	0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.6	0.7	-0.0	-0.0	-0.2
Hearing difficulty/problems: Yes	1.2	1.8	3.9	-1.7	-0.2	2.0	-1.0	1.2
Relative age of first facial hair	0.0	0.1	0.1	0.4	0.1	-0.4	0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	-0.7	-1.0	-0.1	-0.2	-0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.3	0.4	0.1	-1.1	0.6	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	-0.8	-1.3	0.8	-0.7	0.4
Systolic blood pressure, automated reading	0.4	1.1	2.8	1.2	0.3	-1.0	0.5	-1.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.6	-0.2	-0.2	0.5	-0.6
Angina	0.1	0.1	0.3	-0.0	0.0	0.2	-0.5	0.3
Medication for hormone replacement therapy	1.6	1.8	3.0	1.3	0.4	-1.7	1.5	-1.3
Vitamin and mineral supplements	0.8	1.1	2.9	0.4	1.7	-0.8	0.8	-1.0
Supplements: Zinc	0.9	1.0	1.6	-0.8	-1.3	1.2	0.1	1.2
Medication: Co-codamol	0.3	0.3	0.6	-0.5	0.8	0.3	-0.7	-0.2
Medication: Metformin	0.2	0.2	1.0	1.0	0.2	-0.0	0.2	0.1
Diabetes (father)	0.6	0.7	3.2	0.4	1.8	0.2	-0.5	-0.1
Diabetes (mother)	0.2	0.2	0.6	-0.0	-0.8	-0.7	0.1	-0.1
Severe depression (siblings)	0.1	0.1	0.5	0.3	0.7	0.2	-0.3	-0.0
Pack years adult smoking proportion	0.3	0.5	1.6	-0.0	0.6	-0.8	-0.1	-1.3
Impedance of leg (right)	0.3	1.3	2.1	-1.4	-1.0	1.0	-1.4	0.4
Leg fat-free mass (left)	0.1	0.7	1.4	0.8	0.5	-1.1	1.2	-0.4
Trunk fat percentage	0.0	0.1	0.3	0.2	0.3	-0.3	-0.4	0.5
Hand grip strength (right)	0.4	1.1	3.2	0.5	1.8	-0.8	0.6	-1.1
Townsend deprivation index at recruitment	0.6	0.9	2.2	1.3	1.5	-0.4	-0.2	-0.7
Current tobacco smoking	0.3	0.5	1.3	-0.3	-1.0	0.1	-1.1	-0.0
Average weekly fortified wine intake	1.4	1.7	2.6	-1.5	0.2	1.6	-1.2	1.4
Maternal smoking around birth	2.3	3.4	5.4	2.3	-0.5	-1.8	2.2	-1.8
Fed-up feelings	0.4	0.8	1.8	-0.8	-0.5	0.9	-1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	0.6	1.0	-0.1	-0.1	-0.5
Relative age voice broke	0.2	0.4	0.7	0.3	-0.6	0.8	0.3	0.7
Taking other prescription medications	0.7	1.1	4.2	-0.6	-2.0	0.2	-0.3	0.8
Age when periods started (menarche)	0.1	0.2	0.4	0.2	0.7	-0.1	0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	7.8	9.0	12.0	3.1	2.8	-3.0	2.5	-3.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.6	0.4	0.4	0.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.7	-1.6	-0.3	0.5	-1.0	0.3
Qualifications: CSEs or equivalent	0.4	0.6	1.5	0.5	-1.2	-0.2	0.9	-0.3
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.7	-0.8	0.1	-0.4	0.2
High blood pressure	0.9	2.4	4.4	0.7	-0.0	-2.0	1.8	-2.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.1	-0.4	-1.1	1.2	-0.3	1.5
Multivitamins +/- minerals	0.3	0.4	1.2	1.1	-0.0	-0.4	0.7	0.1
Stomach or abdominal pain in last month	0.5	0.7	1.2	-1.1	1.0	0.9	-0.5	0.3
Supplements: Glucosamine	0.4	0.5	0.8	0.7	-0.9	-0.6	0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.2	-0.2	1.1	-0.2	0.3	-0.7
Medication: Atenolol	0.2	0.3	0.6	-0.2	-0.5	-0.0	-0.8	-0.8
Medication: Levothyroxine sodium	0.7	1.2	3.5	1.0	-1.3	-0.2	1.9	-0.2
Sitting height	0.1	0.7	1.6	-0.8	-1.0	-0.2	1.3	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	0.2	-0.6	-0.5	1.5	-0.0
High blood pressure (mother)	0.2	0.2	0.6	0.4	0.3	-0.5	-0.2	-0.8
Body mass index (BMI)	0.1	0.4	0.8	0.8	0.9	-0.5	-0.3	0.5
Impedance of leg (left)	0.2	0.8	1.7	-1.3	-0.2	0.9	-1.1	0.1
Leg predicted mass (left)	0.1	0.7	1.3	0.7	0.4	-1.1	1.1	-0.3
Trunk fat mass	0.0	0.1	0.6	0.1	0.0	-0.2	-0.3	0.8
Waist circumference	0.2	0.6	1.5	0.8	1.2	-0.8	-0.6	0.2
Number of incorrect matches in round	0.6	1.0	1.7	-1.3	-1.0	1.2	0.1	1.1
Past tobacco smoking	0.6	1.2	3.1	-1.8	-0.2	1.4	-0.3	0.8
Alcohol usually taken with meals	1.7	2.8	3.7	1.9	1.9	-1.4	1.7	-1.3
Nervous feelings	0.1	0.2	0.6	0.0	-0.8	0.4	0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.5	1.1	-0.1	0.3	-0.5
Hearing difficulty/problems with background noise	1.8	2.9	4.6	-1.9	-0.7	2.1	-1.4	1.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	0.9	0.4	-0.8	1.5	-0.4
Had menopause	2.5	3.2	7.5	-1.9	-2.7	0.9	-1.6	1.1
Had other major operations	0.9	1.1	1.6	1.3	0.2	-1.3	1.3	-0.9
Forced vital capacity (FVC)	0.5	1.9	4.8	-2.2	-1.5	1.3	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	1.1	0.2	-0.1	0.9	-0.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.6	-1.2	-1.2	1.0	-1.2	0.9
Qualifications: None of the above	1.5	3.3	6.2	-1.6	-1.2	2.5	-1.7	1.6
Financial difficulties in last 2 years	0.3	0.4	1.3	1.1	0.4	-0.4	0.4	-0.3
Mouth/teeth dental problems	2.7	4.1	7.7	1.3	1.6	-2.0	2.8	-2.0
Heart attack	0.2	0.3	0.6	0.8	0.5	-0.4	0.6	-0.3
Allergy	0.5	1.1	2.0	0.3	1.2	-1.3	0.3	-1.4
Pain all over the body in last month	0.2	0.2	0.9	-0.9	-0.3	0.1	-0.1	0.1
Diabetes (self-reported)	0.4	0.5	1.8	1.4	0.3	-0.5	0.2	-0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.4	1.4	0.7	-1.0	1.5	-0.1
Medication: Ramipril	0.4	0.5	1.3	1.2	0.6	-0.6	0.6	-0.2
Medication: Simvastatin	3.7	5.5	7.7	2.8	1.6	-2.8	1.9	-2.4
Fluid intelligence score	2.1	4.3	8.8	3.0	2.3	-2.1	1.6	-0.7
Illnesses of siblings	0.8	1.1	3.0	-0.2	-1.7	0.8	0.7	1.0
Neuroticism score	0.2	0.4	0.6	0.6	0.8	-0.1	0.6	-0.7
Weight	0.0	0.1	0.2	0.3	0.2	-0.4	0.2	0.4
Impedance of arm (right)	0.1	0.5	0.9	-0.7	-1.0	0.9	-0.4	0.2
Arm fat percentage (right)	0.1	0.3	0.5	0.4	0.6	-0.2	-0.5	0.7
Trunk fat-free mass	0.1	0.4	1.5	0.3	-0.3	-0.5	1.2	0.3
Hip circumference	0.1	0.3	0.8	0.9	0.5	-0.5	0.4	-0.0
Time employed in main current job	0.1	0.1	0.4	-0.2	-0.6	0.2	0.1	0.2
Alcohol intake versus 10 years previously	1.2	1.8	4.5	1.1	0.8	-2.1	0.6	-1.6
Father’s age at death	0.6	0.8	2.2	0.2	1.5	0.5	1.2	0.1
Worrier / anxious feelings	0.4	0.8	1.1	-1.1	-0.4	1.0	-1.0	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	1.4	0.4	-0.4	0.2	-0.9
Falls in the last year	2.0	2.7	5.3	-0.9	-2.3	1.6	-0.5	2.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.1	-0.3	-0.4	1.3	-0.5	1.4
Number of live births	1.3	1.8	2.9	-1.1	-1.0	1.4	-1.7	1.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	7.2	-2.7	-2.0	2.2	-1.7	2.0
Pulse rate	0.5	0.9	1.7	-0.9	-0.9	1.3	-0.3	1.1
Happiness	1.3	1.6	5.4	1.2	2.3	-0.3	0.8	-0.6
Noisy workplace	0.8	0.9	2.7	-1.3	-0.1	0.1	-1.6	0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.8	-1.4	-2.2	0.9	0.6	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.8	0.7	1.0	-1.3	1.0	-0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	5.4	-0.9	-2.3	1.4	-1.4	1.4
Asthma	0.0	0.1	0.2	-0.4	-0.1	-0.2	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.2	0.3	-0.4	-0.6	-0.6
Medication: Cholesterol lowering	2.1	3.3	4.4	2.1	1.4	-1.8	2.0	-1.6
Depression (self-reported)	0.9	1.0	2.1	1.3	1.4	-0.6	0.8	-0.6
Medication: Lansoprazole	0.7	0.8	1.2	-0.6	-0.8	1.1	-1.1	0.8
Prospective memory result	0.3	0.4	0.8	-0.1	-0.7	-0.7	-0.4	-0.9
Lung cancer (father)	1.2	1.4	3.1	-0.6	-1.8	1.0	0.0	1.7
Illnesses of mother	3.1	3.8	5.9	-2.2	-1.3	2.4	-0.8	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	7.8	-2.8	-1.5	1.8	-2.0	1.6
Pulse wave Arterial Stiffness index	1.4	1.6	2.6	1.3	-0.1	-1.6	1.1	-1.6
Impedance of arm (left)	0.1	0.2	0.6	-0.8	-0.5	0.4	-0.4	-0.0
Arm fat mass (right)	0.0	0.2	0.5	0.2	0.3	-0.1	-0.3	0.7
Trunk predicted mass	0.1	0.4	1.7	0.3	-0.3	-0.5	1.3	0.2
Standing height	0.1	0.9	1.6	-1.1	-1.3	0.3	1.2	0.0
Length of working week for main job	1.8	2.0	3.7	-1.3	-1.2	1.9	-1.4	1.1
Exposure to tobacco smoke at home	0.8	0.9	1.8	1.0	-0.2	-1.2	-0.1	-1.3
Breastfed as a baby	0.3	0.4	1.9	-0.1	-1.4	-0.1	0.3	0.1
Tense / ‘highly strung’	0.1	0.2	0.3	0.1	0.6	0.4	0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	0.1	1.1	-0.6	-1.2	-0.4
Hair/balding pattern: Pattern 4	0.5	1.1	1.9	1.1	1.4	-0.5	1.1	-1.0
Birth weight of first child	0.3	0.5	1.1	-1.0	-0.5	1.1	-0.1	0.3
Peak expiratory flow (PEF)	0.6	1.3	4.3	-0.7	-0.6	0.8	-2.1	1.0
Pulse wave reflection index	0.8	1.0	1.3	0.9	0.4	-1.1	1.2	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	0.9	0.7	-0.7	0.2	-0.3
Loud music exposure frequency	0.8	0.9	2.3	-1.2	0.0	0.8	-1.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.3	0.3	-0.8	-0.6	1.5	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	0.2	-0.2	0.5	-1.0	0.1
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.1	-0.3	1.1	-0.2	0.7
Medication: Paracetamol	0.6	1.0	2.3	0.6	-0.4	-1.5	-0.0	-1.4
Headache pain in last month	1.9	3.2	6.6	-1.5	-1.5	1.5	-2.6	1.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.1	3.2	-1.1	-0.4	1.8	-1.8	1.6
Glaucoma (self-reported)	0.2	0.3	0.6	-0.8	-0.6	0.1	-0.4	0.4
Gout (self-reported)	0.1	0.1	0.2	-0.2	-0.5	0.2	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	0.7	-1.4	0.5	1.6	0.4
Medication: Amlodipine	1.0	1.4	2.4	1.2	0.1	-1.5	1.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	-0.1	-0.8	-0.5	-0.4	0.1
Birth weight	0.6	1.3	3.0	0.7	-0.1	-1.7	0.6	-1.7
Chronic bronchitis/emphysema (mother)	2.3	2.7	6.0	1.8	0.2	-1.3	2.4	-1.5
High blood pressure (siblings)	0.5	0.7	1.5	0.5	1.2	-0.8	-0.7	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	3.8	-2.0	-0.9	0.5	-0.2	0.2
Body fat percentage	0.1	0.3	0.8	-0.0	0.1	0.0	-0.9	0.9
Leg fat percentage (right)	0.2	0.6	1.9	-0.2	0.1	0.2	-1.4	1.1
Arm fat-free mass (right)	0.1	0.4	1.0	0.3	0.2	-0.8	1.0	-0.0
Exposure to tobacco smoke outside home	0.6	0.7	0.9	-0.9	-0.9	0.7	-0.8	0.9
Comparative body size at age 10	0.3	0.8	3.1	-0.7	-0.2	-0.3	-1.8	0.1
Number of full brothers	0.6	0.7	1.3	-1.2	-0.5	0.8	-0.4	1.1
Worry too long after embarrassment	0.1	0.2	0.3	0.1	0.6	0.5	-0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.5	-0.6	-0.3	-1.1	-0.8
Wheeze or whistling in the chest in last year	0.4	0.8	1.2	-1.0	-0.9	0.4	-1.1	0.9
Number of children fathered	1.3	1.5	5.1	-0.6	-2.3	1.2	0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.8	-0.2	0.5	-0.1	0.2
Age at first live birth	0.3	0.5	1.4	0.4	0.8	-1.2	0.6	-0.5
Pulse wave peak to peak time	1.9	2.2	3.6	-1.6	-0.3	1.9	-1.2	1.9
Health satisfaction	0.2	0.2	0.7	0.8	0.3	0.4	-0.1	0.2
Shortness of breath walking on level ground	1.1	1.3	3.1	0.4	-1.0	1.5	-0.2	1.8
Qualifications: College or University degree	0.2	0.7	2.4	0.1	1.6	-0.8	0.8	-0.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.2	-0.7	-0.1	0.3	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.6	0.4	-0.3	0.6	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.8	-0.3	0.2	-0.4	-0.4
Medication for pain relief, constipation, heartburn	1.4	2.5	3.9	-1.6	-1.5	1.9	0.3	2.0
Neck or shoulder pain in last month	1.9	2.7	4.7	-1.0	-2.2	1.5	-1.7	1.5
Medication: Blood pressure	1.0	1.7	2.9	0.7	0.1	-1.6	1.6	-1.7
Angina (self-reported)	0.3	0.4	0.7	-0.4	-0.3	0.7	-0.8	0.8
Migraine (self-reported)	0.3	0.3	0.9	-0.5	0.1	0.5	-1.0	0.5
Medication: Ibuprofen	0.5	0.6	1.7	-1.0	-0.3	0.1	-1.3	-0.3
Medication: Allopurinol	0.3	0.5	1.6	-0.2	0.5	-0.2	-0.6	-1.3
Medication: Omeprazole	0.4	0.4	1.5	-0.0	1.2	0.1	-0.6	0.6
Medication: Seretide 50 evohaler	1.9	2.2	3.3	1.0	1.4	-1.8	1.3	-1.8
Mean time to correctly identify matches	1.1	2.0	4.6	-2.1	-0.9	1.0	-1.9	0.3
Heart disease (mother)	2.8	3.4	6.8	1.4	2.0	-2.6	0.6	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.0	9.9	3.1	1.1	-1.7	1.9	-1.5
Whole body fat mass	0.0	0.2	0.6	0.2	0.2	-0.1	-0.5	0.8
Leg fat mass (right)	0.1	0.6	1.3	-0.4	-0.1	0.3	-1.2	1.1
Arm predicted mass (right)	0.1	0.4	1.3	0.5	0.1	-0.8	1.1	-0.0
Pulse rate, automated reading	0.5	1.6	2.9	-1.3	-0.9	1.6	0.0	1.7
Alcohol intake frequency.	0.1	0.3	0.9	-0.0	-1.0	0.0	0.0	0.8
Comparative height size at age 10	0.4	2.1	2.7	-1.4	-1.6	1.5	-1.3	1.2
Number of full sisters	0.5	0.6	1.7	0.3	-1.3	0.9	-0.3	0.3
Suffer from ‘nerves’	0.1	0.2	0.7	0.4	-0.2	-0.0	-0.2	-0.8
Overall health rating	0.6	1.3	2.5	1.6	1.5	-0.6	0.4	-1.1
Chest pain or discomfort	4.4	6.3	9.2	2.4	2.1	-3.0	1.8	-2.9
Had major operations	0.7	0.8	2.6	-0.1	-1.0	0.4	-0.4	1.6
Age at last live birth	0.0	0.0	0.0	0.0	-0.1	-0.2	0.1	0.2
Family relationship satisfaction	0.9	1.1	5.3	0.1	2.3	-0.2	0.1	-0.5
Leg pain on walking	0.3	0.4	0.8	0.9	-0.3	0.7	-0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.5	-0.6	-1.2	1.4	-1.6	1.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.1	-0.2	1.1	0.1	-0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.3	-0.3	0.1	0.0	-0.2
Medication: Aspirin	1.6	2.1	3.5	1.8	1.9	-1.4	0.6	-1.4
Supplements: Vitamin C	2.3	2.7	4.4	-1.7	-2.1	1.3	-1.5	1.4
Knee pain experienced in last month	1.2	1.9	5.1	-0.6	-1.0	1.4	-2.3	1.1
Hypertension (Self-reported)	0.8	2.1	3.9	0.8	-0.4	-2.0	1.6	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.9	-0.8	-1.4	-0.0	0.2	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.7	0.7	0.9	-0.0	0.2	0.3
Illnesses of siblings: Diabetes	0.5	0.7	1.8	-0.6	-0.3	1.1	-0.1	1.3
Smoking status: Previous	0.8	1.2	2.2	1.2	0.0	-1.5	0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.4	0.2	-0.3	0.7	-0.4
Whole body fat-free mass	0.1	0.6	1.8	0.5	0.1	-0.8	1.4	-0.0
Leg fat-free mass (right)	0.2	1.3	2.4	1.0	0.9	-1.3	1.6	-0.6
Arm fat percentage (left)	0.1	0.3	0.6	0.4	0.7	-0.3	-0.6	0.7
Average weekly red wine intake	0.2	0.3	0.9	1.0	0.1	-0.4	0.8	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.9	0.7	-0.2	0.9	-0.4
Mood swings	0.4	0.7	1.1	1.0	0.8	-0.5	0.5	-1.0
Loneliness, isolation	0.8	1.1	2.5	0.7	1.1	-1.0	0.1	-1.6
Long-standing illness, disability or infirmity	0.0	0.1	0.2	-0.2	0.1	-0.0	-0.4	-0.2
Ever had bowel cancer screening	0.4	0.5	1.7	-1.3	-0.8	0.2	-0.1	-0.0
Diabetes diagnosed by doctor	0.2	0.3	1.5	1.2	-0.2	0.1	0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	-1.2	-0.9	0.3	-0.6	1.0
Friendships satisfaction	1.3	1.7	2.5	0.9	1.5	-1.0	1.6	-1.4
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.2	-0.5	0.0	0.1	0.2
Commuting to job workplace: Walk	0.4	0.5	1.1	0.3	0.1	-1.0	0.4	-0.9
Eye problems/disorders: Cataract	0.3	0.4	1.1	0.3	1.0	-0.4	-0.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.3	-2.2	-0.2	1.2	-2.3	1.6
Medication for cholesterol	0.3	0.4	0.9	-0.9	-0.2	0.8	0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	-0.4	-0.5	0.7	-0.3	0.5
Back pain experienced in last month	0.8	1.1	2.2	-1.1	-0.3	1.0	-1.5	1.1
Mineral and other dietary supplements	0.5	0.7	2.0	0.0	1.4	0.6	0.8	0.6
Breast cancer (self-reported)	2.5	3.0	5.4	1.9	2.3	-1.4	1.2	-1.7
Asthma (self-reported)	0.1	0.1	0.4	-0.6	-0.2	-0.3	-0.0	0.1
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.0	0.7	-0.5	0.6	-0.3
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.3	0.3	0.0	0.2	-0.0
Medication: Aspirin	2.0	2.6	5.1	1.7	2.3	-1.5	0.4	-1.5
Medication: Gliclazide	0.2	0.3	1.0	-0.4	0.4	0.1	-1.0	-0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.4	-0.7	-1.8	0.2	-0.7	-0.0
Smoking status: Current	0.5	0.8	2.6	-0.6	-0.8	0.5	-1.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	4.5	-2.0	-0.9	2.1	-1.8	1.9
Whole body water mass	0.1	0.6	1.9	0.5	0.0	-0.8	1.4	-0.0
Leg predicted mass (right)	0.2	1.3	2.5	1.0	0.9	-1.4	1.6	-0.6
Arm fat mass (left)	0.1	0.2	0.5	0.3	0.5	-0.2	-0.4	0.7
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	0.8	-0.6	-1.4	1.9	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.3	0.1	1.2	0.4	0.2	0.7
Miserableness	0.1	0.1	0.3	-0.2	-0.3	-0.0	-0.4	0.5
Guilty feelings	1.0	1.5	5.6	0.8	2.4	-0.3	0.6	-0.8
Wears glasses or contact lenses	0.5	0.6	2.1	1.4	-0.8	-0.3	0.5	0.1
Ever taken oral contraceptive pill	0.6	0.6	1.3	1.1	0.2	-1.0	0.8	-0.6
Hearing aid user	0.4	0.4	1.0	-0.5	-0.2	0.8	-1.0	0.5
Mother’s age at death	1.8	2.3	5.1	1.1	1.8	-1.4	0.4	-2.2
Financial situation satisfaction	2.9	3.6	6.9	2.6	2.2	-1.5	1.6	-1.2
Tinnitus: Yes, now most or all of the time	1.8	2.1	2.9	1.4	1.4	-1.7	1.0	-1.7
Commuting to job workplace: Public transport	2.1	2.5	3.5	1.9	1.0	-1.8	1.4	-1.6
Eye problems/disorders: Glaucoma	1.0	1.1	2.9	-1.5	-0.2	0.6	-1.7	0.5
Medication: Blood pressure	0.3	0.6	1.3	-1.0	-0.6	-0.0	-1.1	-0.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.2	-1.6	-1.5	1.8	-1.4	1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	0.1	-1.8	-0.1	-0.9	-0.1
High cholesterol (Self-reported)	4.3	7.6	10.1	3.2	2.0	-3.0	2.9	-2.6
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	0.1	-0.3	0.2	-0.0
Medication: Paracetamol	0.6	1.0	2.3	0.4	-0.8	-1.5	-0.3	-1.3
Medication: Lisinopril	0.2	0.2	0.4	0.3	-0.6	-0.4	0.2	-0.6
Medication: Atorvastatin	4.6	5.7	6.8	2.6	2.5	-2.0	2.3	-2.5
Illnesses of father: High blood pressure	1.2	1.5	2.9	1.0	1.7	-1.2	1.0	-1.0
Alcohol drinker status: Never	0.3	0.3	0.7	-0.6	-0.5	0.5	-0.4	0.8
Ever smoked	1.0	1.7	4.0	2.0	1.0	-1.6	0.2	-0.8
Basal metabolic rate	0.1	0.4	1.2	0.6	0.3	-0.8	1.1	0.0
Leg fat percentage (left)	0.2	0.6	1.4	-0.2	0.6	0.2	-1.2	0.9
Arm fat-free mass (left)	0.1	0.3	0.9	0.2	0.1	-0.6	0.9	0.1
Number of operations (self-reported)	0.9	1.4	3.0	0.8	1.3	-1.7	0.8	-1.0
Average weekly beer plus cider intake	0.2	0.2	0.6	0.4	0.2	-0.5	0.8	-0.4
Irritability	0.9	1.6	3.1	1.3	1.8	-0.7	1.3	-1.1
Risk taking	0.9	1.2	2.9	-1.7	-0.7	1.1	-1.2	0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	5.5	-1.0	-2.4	0.4	-0.4	1.2
Fractured/broken bones in last 5 years	4.5	5.8	10.7	-2.8	-1.2	1.8	-3.3	2.4
Age started oral contraceptive pill	0.5	0.6	2.0	-1.4	-0.5	0.4	-0.7	0.3
Diastolic blood pressure, automated reading	0.9	2.7	4.3	1.2	0.6	-2.0	2.1	-1.8
Ever depressed for a whole week	2.6	3.2	5.6	-1.8	-0.2	2.4	-2.1	1.7
Unable to work because of sickness or disability	0.1	0.2	0.5	0.1	-0.2	0.3	-0.7	-0.4
Commuting to job workplace: Cycle	0.8	1.0	3.0	-0.4	-1.7	0.6	-0.5	1.1
Myopia	2.7	3.9	6.9	2.6	1.6	-1.6	2.4	-1.3
Vascular/heart problems diagnosed by doctor	1.2	3.4	6.2	-1.1	-0.5	2.5	-1.8	2.5
Cholesterol lowering medication	1.0	1.5	2.4	1.5	1.1	-1.3	0.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.0	0.2	1.4	-0.4	-0.2	-0.3
Pain experienced in last month	3.4	5.6	8.5	2.1	2.1	-2.6	2.9	-2.0
Supplements: Calcium	0.3	0.4	1.0	-0.8	0.3	-0.3	-0.1	-1.0
Basal cell carcinoma (self-reported)	1.3	1.5	3.7	-1.9	-0.8	0.2	-1.7	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	0.7	-0.4	0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.5	0.3	0.1	0.7	0.1	0.4
Heart disease (siblings)	0.3	0.4	1.1	-0.5	0.1	-0.7	0.6	-1.0
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.6	0.2	-0.5	0.5	-0.9
Pack years of smoking	0.1	0.2	0.6	-0.4	0.1	-0.3	-0.4	-0.7
Impedance of whole body	0.2	0.8	2.0	-1.4	-0.6	0.8	-0.9	0.0
Leg fat mass (left)	0.1	0.4	1.0	-0.3	0.2	0.3	-0.9	1.0
Arm predicted mass (left)	0.1	0.3	1.0	0.2	-0.1	-0.5	1.0	0.2