Hub : Genes

TAL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1480	0.069	0.00770	-0.002	NA	0.004	NA	-0.001	4.2e-01	NA	1.8e-01	NA	3.8e-01
2	GTEx	Stomach	0.2080	0.071	0.00026	0.102	NA	0.035	NA	0.003	1.3e-05	NA	8.5e-03	NA	2.3e-01
3	YFS	Blood	0.0269	0.010	0.00054	0.018	0.014	0.017	0.017	0.016	8.5e-07	1.2e-05	2.6e-06	2.6e-06	5.2e-06
4	TCGA	Bladder Urothelial Carcinoma	0.0340	0.019	0.00960	0.020	0.019	0.015	NA	0.011	7.7e-03	9.2e-03	1.8e-02	NA	4.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.2	1.8	-1.0	-0.7	1.3	-1.2
Bipolar Disorder or Schizophrenia	0.9	2.2	3.7	-0.6	-1.7	1.3	-1.9
Depressed Affect (Nagel 2018)	5.9	12.3	18.2	2.6	3.0	-3.9	4.3
Depression (Nagel 2018)	2.1	3.1	4.6	0.8	2.0	-1.9	2.1
Intelligence (Savage-Jansen 2018)	4.4	13.4	19.4	3.0	3.3	-4.4	3.8
Neuroticism (Nagel 2018)	4.4	10.3	14.8	2.8	2.6	-3.9	3.4
Schizophrenia (2018)	0.6	1.3	2.5	0.0	-1.6	0.6	-1.5
Schizophrenia vs Biploar Disorder	0.3	0.5	0.9	-0.1	-0.2	0.9	-1.0
Worry (Nagel 2018)	0.6	1.2	2.4	0.8	1.2	-1.6	0.5
Alzheimer’s Disease (in mother)	1.5	1.8	4.1	0.8	0.5	-1.5	2.0
Alzheimer’s Disease (in father)	1.6	1.7	3.3	1.8	1.1	-0.4	1.4
Alzheimer’s Disease (including proxy)	3.5	5.0	9.0	2.0	2.0	-1.8	3.0
Crohns Disease (2017)	0.1	0.2	0.5	0.4	0.7	0.2	0.4
Irritable Bowel Disease (IBD)	0.5	1.1	2.8	1.1	1.7	0.3	0.6
Ulcerative Colitis (UC)	0.7	1.3	2.8	1.5	1.7	0.4	-0.0
Major Depression (MDD)	2.0	2.5	4.4	0.5	1.8	-2.1	1.5
Reaction Time	0.1	0.2	0.6	0.8	0.0	0.1	-0.1
Verbal and Numeric Reasoning (VNR)	3.4	8.1	10.3	2.2	3.2	-3.1	2.8
Breast Cancer	0.4	0.9	2.4	0.9	0.6	-0.2	1.6
Ovarian Cancer	0.1	0.1	0.4	0.4	-0.6	-0.1	-0.2
Prostate Cancer	0.4	0.5	0.7	-0.7	0.7	0.8	-0.6
Age at First Birth	0.8	1.2	2.5	1.6	-0.7	1.2	-0.6
Bipolar Disorder (2011)	2.6	2.5	2.9	-1.4	-1.5	1.7	-1.7
Body Mass Index (BMI) (2010)	7.4	10.1	14.4	3.3	2.0	-3.8	3.4
Coronary Artery Disease (CAD)	0.3	0.3	1.1	1.1	0.1	-0.4	-0.1
Crohns Disease (2012)	0.7	1.2	2.0	-1.0	-0.3	1.2	-1.4
Mean Putamen Volume	0.5	0.5	1.1	-0.6	1.1	0.1	0.8
Fasting Glucose	0.7	0.9	1.6	-1.0	-0.5	0.8	-1.3
HbA1C	0.6	0.6	1.0	0.9	-0.2	-1.0	0.8
HDL Cholesterol	1.1	1.8	2.7	-0.9	-1.2	1.5	-1.7
LDL Cholesterol	0.7	1.1	1.8	-1.2	-0.1	1.4	-1.0
Lupus	0.9	1.3	3.8	-0.7	-1.9	0.6	-0.7
Neuroticism (2016)	4.3	6.2	9.3	1.6	2.3	-3.0	2.7
Primary Biliary Cirrhosis	0.6	0.9	1.8	-1.1	1.4	-0.6	0.1
Rheumatoid Arthritis	2.1	2.8	4.8	-1.0	-1.0	2.1	-2.2
Schizophrenia (2014)	1.0	2.3	5.6	-0.0	-1.5	1.2	-2.4
Triglycerides	0.9	1.5	2.7	0.5	1.2	-1.3	1.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.2	-0.6	0.9	-0.4
Ulcerative Colitis	0.4	0.6	1.6	-0.9	1.2	0.0	0.0
Blood Eosinophil Count	1.4	10.7	23.2	0.5	1.9	-4.8	4.0
Blood Platelet Count	2.0	23.7	59.8	2.2	2.5	-7.7	4.9
Blood Red Count	5.1	49.0	62.6	4.7	7.9	-7.5	7.5
Blood White Count	1.7	12.9	17.6	4.2	3.2	-3.0	3.8
Heel T-Score	0.3	2.7	6.2	2.5	1.5	-1.3	0.8
BMI	5.8	33.4	62.4	4.7	2.6	-7.9	6.5
Height	0.1	2.2	7.4	-0.9	2.7	0.5	-0.7
Waist Hip Ratio (WHR)	0.4	1.9	5.4	-0.1	-0.2	2.3	-1.4
Systolic Blood Pressure	0.5	2.6	4.7	2.2	1.0	-1.3	1.8
Smoking Status	0.6	1.5	3.0	0.4	0.4	-1.6	1.7
Allergy or Eczema	2.0	5.3	8.1	-2.1	-1.6	2.5	-2.8
Cardiovascular Disease	3.5	11.5	17.6	3.3	2.0	-4.2	3.7
Hypothyroidism (self reported)	0.7	1.7	4.1	0.1	1.2	-2.0	1.0
Respiratory disease	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.8	1.9	0.5	-1.7	1.0
Lung FEV1/FVC ratio	3.9	20.0	29.9	4.1	2.9	-5.5	5.0
Lung FVC	0.2	1.2	2.1	1.3	0.1	-0.9	1.5
Neuroticism	4.5	10.9	15.1	3.5	2.6	-3.9	3.0
Chronotype (morning person)	0.8	2.0	3.1	-1.8	-0.4	1.8	-1.2
Hair Pigment	0.0	0.7	1.4	1.2	-0.8	-0.5	0.6
Tanning	0.0	0.6	1.0	-1.0	-1.0	0.6	-0.2
Hand grip strength (left)	0.8	2.2	4.8	-0.1	2.2	-1.5	1.4
Number of treatments/medications taken	0.4	0.8	1.8	0.3	-0.6	-1.3	0.9
Average weekly spirits intake	1.1	1.4	3.1	-0.9	-1.8	1.1	-0.7
Sensitivity / hurt feelings	1.1	1.8	5.3	2.3	-0.4	-1.2	0.6
Frequency of depressed mood in last 2 weeks	3.4	4.8	6.8	1.8	2.2	-2.1	2.6
Hearing difficulty/problems: Yes	0.4	0.6	1.4	0.7	0.6	-1.2	0.5
Relative age of first facial hair	0.1	0.2	0.4	-0.7	0.5	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	3.9	1.6	0.5	-2.0	1.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.6	-1.1	-1.2	1.2	-1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	-0.5	1.1	-0.9	0.7
Systolic blood pressure, automated reading	1.1	3.2	4.6	2.1	1.2	-1.7	1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.7	-0.6	0.3	-0.4
Angina	0.8	1.0	3.6	0.6	-1.9	0.0	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.7	0.8	-0.3	-0.3	0.2
Vitamin and mineral supplements	1.1	1.4	1.8	1.0	1.1	-1.3	1.3
Supplements: Zinc	0.2	0.2	0.4	0.7	-0.4	0.1	-0.5
Medication: Co-codamol	0.6	0.6	1.3	0.7	0.5	-1.1	0.8
Medication: Metformin	0.0	0.1	0.1	-0.0	0.2	-0.3	0.4
Diabetes (father)	2.3	2.8	4.7	2.2	0.1	-1.3	2.2
Diabetes (mother)	0.2	0.3	0.4	-0.5	-0.1	-0.6	-0.6
Severe depression (siblings)	3.1	3.5	4.7	1.1	2.2	-2.2	1.8
Pack years adult smoking proportion	1.0	1.5	3.7	0.9	0.8	-1.0	1.9
Impedance of leg (right)	1.8	8.6	20.9	-1.7	-0.7	4.6	-3.2
Leg fat-free mass (left)	2.7	14.4	30.4	2.1	2.5	-5.5	4.0
Trunk fat percentage	4.4	17.5	29.2	3.5	2.7	-5.4	4.6
Hand grip strength (right)	0.7	2.0	3.7	-0.1	1.9	-1.6	1.4
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.0	0.1	0.7	-0.9
Current tobacco smoking	1.3	2.1	4.6	0.6	1.5	-1.1	2.1
Average weekly fortified wine intake	2.1	2.4	4.5	1.1	1.1	-2.1	1.7
Maternal smoking around birth	3.4	4.9	8.4	1.6	1.6	-2.9	2.5
Fed-up feelings	3.7	6.7	10.5	2.3	3.2	-2.3	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.5	0.5	1.6	-1.3	1.1
Relative age voice broke	0.3	0.4	0.7	-0.3	0.5	0.9	-0.8
Taking other prescription medications	0.2	0.3	0.7	0.1	-0.6	-0.8	0.4
Age when periods started (menarche)	0.5	1.2	2.7	1.3	1.7	0.5	-0.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.9	1.4	0.4	-1.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	-1.1	0.0	-0.7	-0.3
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.1	1.8	0.8	-1.7	2.0
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	-0.3	0.9	-0.9
Serious illness, injury or assault to yourself	1.1	1.3	1.7	1.1	1.2	-1.0	1.3
High blood pressure	1.2	3.3	6.5	1.3	-0.0	-2.5	2.2
Hayfever, allergic rhinitis or eczema	1.9	4.0	6.4	-1.9	-0.5	2.4	-2.5
Multivitamins +/- minerals	1.2	1.5	3.0	-0.9	-1.7	1.1	-1.1
Stomach or abdominal pain in last month	1.1	1.4	2.4	1.1	1.4	-0.2	1.6
Supplements: Glucosamine	1.2	1.5	2.8	-1.4	0.1	-1.7	1.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.1	-0.3	0.7	0.4
Medication: Atenolol	0.2	0.3	0.5	0.6	-0.7	-0.4	0.3
Medication: Levothyroxine sodium	0.5	0.8	1.5	-1.2	1.0	-0.8	0.1
Sitting height	0.1	0.4	0.9	-1.0	0.3	0.4	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.7	-0.8	-0.1	0.2
High blood pressure (mother)	0.6	0.9	2.0	0.2	0.3	-1.4	1.2
Body mass index (BMI)	5.4	22.8	44.5	3.6	2.0	-6.7	5.5
Impedance of leg (left)	2.4	11.5	28.3	-1.7	-0.9	5.3	-3.8
Leg predicted mass (left)	2.7	14.2	29.4	2.2	2.5	-5.4	4.0
Trunk fat mass	4.8	20.7	36.4	3.4	3.1	-6.0	5.0
Waist circumference	4.2	15.4	28.5	2.8	2.4	-5.3	4.4
Number of incorrect matches in round	4.1	6.9	10.9	-1.2	-3.3	2.9	-2.6
Past tobacco smoking	0.3	0.6	1.4	0.2	0.3	1.2	-1.0
Alcohol usually taken with meals	0.3	0.6	1.1	-0.9	0.5	-1.1	-0.1
Nervous feelings	0.3	0.6	1.4	1.2	0.3	-0.7	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	0.2	1.5	-1.1	1.0
Hearing difficulty/problems with background noise	1.0	1.6	3.6	1.9	1.0	-0.7	1.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.2	0.0	0.4	0.6
Had menopause	0.3	0.4	1.6	0.1	-1.3	0.2	0.1
Had other major operations	0.7	0.9	2.4	0.0	0.0	-1.5	1.0
Forced vital capacity (FVC)	0.1	0.4	1.0	1.0	0.6	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.3	-1.5	0.9	-1.0	0.2
Ever unenthusiastic/disinterested for a whole week	4.0	4.9	8.5	2.5	1.1	-2.9	1.9
Qualifications: None of the above	0.5	1.0	3.0	0.8	-1.7	-0.2	0.7
Financial difficulties in last 2 years	1.2	1.6	3.0	0.0	0.8	-1.6	1.7
Mouth/teeth dental problems	0.7	1.0	1.5	-1.2	-0.8	1.2	-0.8
Heart attack	2.0	2.6	6.4	0.6	1.2	-1.5	2.5
Allergy	1.4	3.2	5.9	1.3	1.2	-1.9	2.4
Pain all over the body in last month	0.3	0.3	0.5	-0.7	-0.1	0.6	-0.7
Diabetes (self-reported)	0.2	0.3	0.5	0.7	0.2	-0.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.2	-0.3	-0.5	0.5
Medication: Ramipril	2.5	3.2	6.2	1.5	0.5	-2.5	2.0
Medication: Simvastatin	0.7	1.0	2.1	0.4	0.1	-1.4	1.3
Fluid intelligence score	4.3	9.0	12.0	2.2	3.5	-3.3	2.9
Illnesses of siblings	0.9	1.3	2.5	-1.6	-0.7	1.1	-1.0
Neuroticism score	5.1	10.7	13.3	3.6	2.6	-3.4	3.3
Weight	3.9	19.0	35.9	3.0	2.9	-6.0	4.7
Impedance of arm (right)	0.6	2.8	7.3	-0.7	0.3	2.7	-1.8
Arm fat percentage (right)	6.1	24.0	43.4	3.7	3.1	-6.6	5.5
Trunk fat-free mass	1.1	6.2	12.6	1.1	2.2	-3.5	2.5
Hip circumference	4.8	20.6	40.6	2.8	3.2	-6.4	4.9
Time employed in main current job	3.1	3.6	11.5	3.4	0.3	-1.1	1.3
Alcohol intake versus 10 years previously	1.8	2.7	4.2	0.4	1.8	-1.7	2.1
Father’s age at death	0.6	0.8	2.2	1.0	1.5	0.5	0.0
Worrier / anxious feelings	1.0	2.0	3.0	1.7	1.2	-1.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.8	5.9	2.3	2.2	-2.4	1.8
Falls in the last year	1.6	2.2	6.9	-2.6	-1.1	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	1.5	1.4	-0.7	-0.2
Number of live births	1.6	2.3	3.9	0.7	1.2	-1.8	2.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.0	2.2	1.5	-1.6	1.2
Pulse rate	0.1	0.1	0.2	0.0	-0.4	0.5	0.2
Happiness	6.8	8.3	14.7	1.9	2.5	-3.8	2.9
Noisy workplace	1.8	2.2	4.5	-2.1	-1.0	1.3	-1.2
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.7	0.7	2.1	-2.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.7	0.5	0.8	-0.8	1.6
Mouth/teeth dental problems: Dentures	0.8	1.4	2.9	-0.2	-1.7	0.7	-1.4
Asthma	0.2	0.4	1.1	-0.4	-0.5	0.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	-0.3	-1.4	0.6	-0.2
Medication: Cholesterol lowering	1.7	2.6	6.0	0.8	1.0	-2.4	1.8
Depression (self-reported)	1.8	2.1	6.6	2.6	0.7	-0.3	1.2
Medication: Lansoprazole	1.0	1.2	3.4	0.6	0.8	-1.9	0.5
Prospective memory result	2.6	3.2	4.6	-1.6	-1.8	2.1	-1.5
Lung cancer (father)	2.0	2.3	3.5	-0.9	-1.3	1.9	-1.9
Illnesses of mother	1.2	1.5	2.9	0.6	-0.8	1.7	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	4.8	2.2	1.8	-1.1	0.9
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-0.8	-0.3	-1.4	1.2
Impedance of arm (left)	0.5	2.4	6.2	-0.6	0.1	2.5	-1.7
Arm fat mass (right)	6.0	24.6	46.2	3.5	3.0	-6.8	5.5
Trunk predicted mass	1.1	6.1	12.4	1.0	2.2	-3.5	2.5
Standing height	0.2	1.9	5.5	-0.9	2.3	0.5	-0.9
Length of working week for main job	0.8	0.9	2.2	0.1	0.5	-1.5	1.1
Exposure to tobacco smoke at home	0.6	0.6	1.7	0.1	-0.4	1.3	-0.8
Breastfed as a baby	1.2	1.5	3.1	-0.8	-1.1	1.8	-0.9
Tense / ‘highly strung’	2.0	3.3	8.0	2.8	1.2	-1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	10.4	3.2	1.2	-2.9	1.8
Hair/balding pattern: Pattern 4	0.7	1.8	6.0	2.4	-1.0	0.1	0.1
Birth weight of first child	0.3	0.6	1.8	-0.5	1.3	-0.6	-0.2
Peak expiratory flow (PEF)	2.2	5.1	10.8	2.0	1.4	-3.3	1.9
Pulse wave reflection index	1.7	2.0	4.2	-2.0	-1.8	0.6	-0.7
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.5	1.3	0.2	-1.4	1.9
Loud music exposure frequency	0.6	0.6	2.3	-0.0	-1.5	0.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.3	-1.8	0.1	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	6.9	0.4	2.6	-1.7	1.7
Blood clot in the leg (DVT)	2.2	2.8	3.8	2.0	1.3	-1.6	1.8
Medication: Paracetamol	0.5	0.8	2.8	-0.6	-1.7	0.5	-0.1
Headache pain in last month	0.1	0.2	0.5	0.0	0.7	-0.5	-0.0
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	8.1	-1.9	-0.7	2.9	-2.0
Glaucoma (self-reported)	0.3	0.4	1.4	0.3	-1.2	-0.2	-0.1
Gout (self-reported)	0.6	0.8	3.0	-0.2	-1.7	-0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	-1.2	1.0	-0.9	0.2
Medication: Amlodipine	0.3	0.4	0.6	0.7	-0.4	-0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.2	0.2	-0.0	-0.1
Birth weight	0.1	0.3	0.5	-0.7	-0.7	0.0	-0.5
Chronic bronchitis/emphysema (mother)	4.6	5.3	9.5	-0.5	-2.2	3.1	-2.6
High blood pressure (siblings)	0.1	0.2	0.3	-0.5	-0.5	0.2	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.7	1.7	0.7	1.3	0.4	-0.4
Body fat percentage	4.9	19.5	33.1	3.6	2.8	-5.8	4.9
Leg fat percentage (right)	4.4	16.1	27.0	3.2	2.3	-5.2	4.7
Arm fat-free mass (right)	1.5	7.6	15.5	1.5	2.2	-3.9	2.8
Exposure to tobacco smoke outside home	1.2	1.6	2.9	-0.2	1.3	-1.3	1.7
Comparative body size at age 10	2.0	5.6	9.1	1.9	1.7	-2.6	3.0
Number of full brothers	0.4	0.6	1.1	0.8	-0.1	-0.7	1.1
Worry too long after embarrassment	1.1	1.8	4.4	2.1	0.5	-1.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.8	1.4	-0.7	1.7	-0.9
Wheeze or whistling in the chest in last year	0.9	1.6	3.4	1.9	0.5	-0.6	1.5
Number of children fathered	0.6	0.6	1.7	0.2	0.5	-1.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.4	-1.9	-1.5	0.9	-1.2
Age at first live birth	0.3	0.5	0.6	0.8	0.8	0.7	-0.4
Pulse wave peak to peak time	0.7	0.8	1.1	0.9	0.7	1.1	-0.9
Health satisfaction	2.5	3.3	6.5	1.5	0.7	-2.5	1.9
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.5	-0.6	0.2	0.0
Qualifications: College or University degree	0.6	1.8	2.4	1.5	1.4	-1.5	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.9	-0.3	0.1	1.4	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.0	0.2	0.4	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.4	0.6	-0.6	0.4	-0.5
Medication for pain relief, constipation, heartburn	0.8	1.4	2.5	-0.7	0.6	1.6	-1.5
Neck or shoulder pain in last month	0.4	0.5	1.0	-0.9	1.0	0.2	0.5
Medication: Blood pressure	1.4	2.5	4.2	1.6	0.2	-2.0	1.8
Angina (self-reported)	0.8	1.0	3.2	0.8	-1.8	-0.2	-0.2
Migraine (self-reported)	0.1	0.2	0.5	0.7	0.4	0.1	-0.3
Medication: Ibuprofen	0.2	0.2	0.4	0.4	-0.7	0.5	-0.0
Medication: Allopurinol	0.2	0.3	0.6	0.6	-0.5	-0.2	0.8
Medication: Omeprazole	4.8	5.8	10.2	1.4	2.5	-3.2	2.1
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.4	0.6	-0.7	0.2
Mean time to correctly identify matches	0.3	0.5	1.3	1.1	-0.8	0.3	-0.2
Heart disease (mother)	1.2	1.5	1.9	1.0	1.4	-1.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	-0.5	0.6	-0.6	0.1
Whole body fat mass	4.9	20.3	37.2	3.3	2.9	-6.1	5.0
Leg fat mass (right)	4.9	19.1	34.7	3.2	2.6	-5.9	5.0
Arm predicted mass (right)	1.3	6.6	14.8	1.3	1.8	-3.9	2.6
Pulse rate, automated reading	0.3	1.0	2.5	0.9	-1.6	0.7	-0.4
Alcohol intake frequency.	2.4	5.6	7.5	2.4	2.2	-2.7	2.0
Comparative height size at age 10	0.1	0.4	1.3	-0.0	1.1	0.3	-0.5
Number of full sisters	3.8	4.6	7.3	0.3	2.7	-2.4	2.3
Suffer from ‘nerves’	0.8	1.3	1.8	0.5	1.3	-1.3	1.2
Overall health rating	2.7	5.8	9.2	2.0	1.7	-3.0	2.7
Chest pain or discomfort	0.7	1.0	2.2	0.3	0.5	-1.3	1.5
Had major operations	0.2	0.3	0.5	-0.2	0.7	-0.7	0.3
Age at last live birth	0.1	0.2	0.5	0.7	0.5	-0.2	0.3
Family relationship satisfaction	2.4	3.0	3.8	1.9	1.1	-1.8	1.9
Leg pain on walking	1.6	2.0	3.6	1.9	-1.8	-1.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	4.7	-2.2	-1.4	2.0	-1.5
Commuting to job workplace: Car/motor vehicle	2.6	3.0	3.8	2.0	1.2	-1.8	1.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.4	-1.8	-0.4	0.3	-1.6
Medication: Aspirin	0.5	0.6	1.3	0.3	-0.3	-1.2	1.0
Supplements: Vitamin C	0.3	0.3	1.1	0.2	0.3	0.2	-1.0
Knee pain experienced in last month	0.5	0.7	1.0	-1.0	-0.8	0.9	-0.7
Hypertension (Self-reported)	1.6	4.5	7.6	1.8	-0.0	-2.8	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	5.8	1.0	2.2	-2.4	1.6
Illnesses of father: Heart disease	0.3	0.4	1.2	0.2	0.5	-1.1	0.3
Illnesses of siblings: Diabetes	1.6	2.0	3.4	0.9	1.3	-1.5	1.8
Smoking status: Previous	0.3	0.5	1.4	0.1	-1.2	-0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.7	1.3	1.3	0.1	0.3
Whole body fat-free mass	1.6	9.0	18.9	1.6	2.3	-4.3	3.1
Leg fat-free mass (right)	2.0	10.9	23.1	1.8	2.2	-4.8	3.5
Arm fat percentage (left)	6.2	24.5	44.5	3.8	2.9	-6.7	5.6
Average weekly red wine intake	1.4	2.0	5.6	-1.0	-2.4	0.7	-1.0
Handedness (chirality/laterality): Left-handed	1.8	2.2	5.7	0.9	2.4	-0.4	1.4
Mood swings	4.0	7.2	9.6	2.6	2.4	-2.5	3.1
Loneliness, isolation	3.3	4.6	6.2	2.2	1.2	-2.4	2.5
Long-standing illness, disability or infirmity	1.7	2.6	4.5	2.1	0.5	-1.9	1.4
Ever had bowel cancer screening	0.4	0.5	1.6	-0.0	-1.3	0.6	-0.3
Diabetes diagnosed by doctor	0.3	0.4	1.1	1.1	-0.3	-0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.3	0.7	-0.4	0.1
Friendships satisfaction	8.5	10.6	14.8	3.1	2.9	-3.8	3.1
Qualifications: nursing, teaching	1.4	2.2	4.9	0.5	1.5	-2.2	1.1
Commuting to job workplace: Walk	0.8	0.9	2.5	-0.9	1.6	0.5	-0.2
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.3	0.7	-0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	0.8	1.1	-0.6	1.3
Medication for cholesterol	0.3	0.4	0.6	-0.6	0.5	0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.1	1.0	0.4	-2.0	1.1
Back pain experienced in last month	0.1	0.1	0.3	0.1	-0.5	-0.2	0.2
Mineral and other dietary supplements	0.6	0.8	1.6	1.2	1.1	0.5	0.0
Breast cancer (self-reported)	0.2	0.3	0.9	-0.3	-0.9	0.4	0.0
Asthma (self-reported)	0.1	0.2	0.5	-0.3	-0.0	0.2	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.7	0.3	-0.4	0.9	-1.3
Osteoarthritis (self-reported)	0.5	0.7	2.0	0.4	-0.2	-1.4	0.7
Medication: Aspirin	0.7	0.9	1.9	0.6	-0.4	-1.4	1.1
Medication: Gliclazide	0.1	0.1	0.1	0.2	-0.1	-0.4	0.3
Illnesses of father: None of the above (group 1)	2.6	3.2	4.5	-1.3	-1.7	2.1	-1.9
Smoking status: Current	0.8	1.3	3.2	-0.1	1.2	-0.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	3.4	1.8	1.8	-1.8	1.6
Whole body water mass	1.6	8.9	19.1	1.5	2.2	-4.4	3.0
Leg predicted mass (right)	2.0	10.5	22.4	1.8	2.1	-4.7	3.4
Arm fat mass (left)	6.0	24.5	46.0	3.6	3.1	-6.8	5.5
Number of self-reported non-cancer illnesses	1.1	1.9	4.0	1.5	-0.2	-2.0	1.2
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-1.1	0.9	-0.7	-0.3
Miserableness	5.4	9.3	14.0	2.5	2.6	-3.2	3.7
Guilty feelings	4.7	7.1	12.2	3.5	1.8	-2.9	2.2
Wears glasses or contact lenses	0.5	0.6	1.1	0.7	-1.1	-0.8	0.3
Ever taken oral contraceptive pill	1.2	1.3	2.5	-1.6	0.2	1.1	-1.2
Hearing aid user	1.9	2.1	3.2	-1.1	-0.8	1.8	-1.8
Mother’s age at death	1.4	1.7	2.8	-1.3	-0.1	1.5	-1.7
Financial situation satisfaction	0.9	1.1	3.2	-0.6	-0.5	-1.8	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.7	-1.3	-0.7	1.2	-1.0
Commuting to job workplace: Public transport	1.1	1.3	1.5	-1.2	-0.9	1.2	-1.2
Eye problems/disorders: Glaucoma	1.0	1.2	3.4	-0.6	-1.8	0.7	-0.8
Medication: Blood pressure	0.6	1.2	2.8	0.2	-0.2	-1.4	1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.3	0.3	-1.5	-1.1	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.6	-1.6	-1.6	0.3	-0.4
High cholesterol (Self-reported)	0.9	1.7	3.6	1.2	0.4	-1.9	1.2
Medication: Bendroflumethiazide	1.9	2.8	4.5	1.3	1.2	-2.1	2.0
Medication: Paracetamol	0.3	0.5	1.2	-0.7	-1.1	0.4	0.4
Medication: Lisinopril	1.0	1.3	3.2	-0.1	-1.8	1.2	-0.7
Medication: Atorvastatin	3.3	4.1	9.2	1.2	1.0	-3.0	2.2
Illnesses of father: High blood pressure	0.7	0.9	1.3	0.6	1.0	-0.9	1.2
Alcohol drinker status: Never	0.1	0.1	0.2	0.3	-0.0	-0.4	-0.1
Ever smoked	0.5	0.8	2.0	0.2	0.8	-0.8	1.4
Basal metabolic rate	2.1	11.8	23.7	2.0	2.6	-4.9	3.6
Leg fat percentage (left)	4.5	16.2	26.1	3.4	2.3	-5.1	4.7
Arm fat-free mass (left)	1.4	7.2	15.4	1.6	2.0	-3.9	2.6
Number of operations (self-reported)	1.5	2.2	4.8	0.1	1.0	-2.2	1.7
Average weekly beer plus cider intake	3.8	5.5	6.3	-2.2	-2.2	2.5	-2.5
Irritability	7.8	13.2	17.9	3.1	2.9	-4.2	4.2
Risk taking	0.3	0.5	1.1	0.1	0.5	-1.1	0.7
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.5	1.2	-1.2	-0.8	0.8
Fractured/broken bones in last 5 years	1.1	1.4	4.5	0.2	-2.1	0.6	-0.8
Age started oral contraceptive pill	1.0	1.3	2.9	0.2	-1.3	1.7	-0.7
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.1	1.0	-0.5	0.4
Ever depressed for a whole week	5.7	7.0	14.4	1.9	1.9	-3.8	2.5
Unable to work because of sickness or disability	1.7	2.2	2.8	1.3	1.5	-1.7	1.5
Commuting to job workplace: Cycle	2.6	3.2	8.0	-2.8	-0.5	1.2	-1.8
Myopia	0.3	0.5	1.4	-1.2	-0.3	0.2	-0.7
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.3	-1.6	0.2	2.5	-2.4
Cholesterol lowering medication	0.3	0.4	0.9	0.3	-1.0	-0.8	0.3
Medication: Omeprazole (e.g. Zanprol)	6.8	8.2	14.3	1.6	3.0	-3.8	2.7
Pain experienced in last month	0.2	0.3	0.5	0.7	0.4	-0.3	0.5
Supplements: Calcium	1.2	1.3	2.7	0.8	1.3	-1.6	0.4
Basal cell carcinoma (self-reported)	0.8	0.9	2.0	-1.4	-0.1	1.2	-0.1
Heart attack/myocardial infarction (self-reported)	1.9	2.5	6.0	0.7	1.1	-1.4	2.4
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.5	2.1	1.2	-1.2	1.5
Heart disease (siblings)	0.2	0.2	0.4	0.5	-0.7	0.1	-0.3
Alcohol drinker status: Previous	1.1	1.2	2.6	1.3	0.2	-1.6	0.8
Pack years of smoking	1.1	1.7	3.7	1.2	0.5	-1.1	1.9
Impedance of whole body	1.5	7.7	20.2	-1.1	-0.5	4.5	-3.0
Leg fat mass (left)	4.8	18.9	34.2	3.2	2.7	-5.8	4.9
Arm predicted mass (left)	1.4	6.9	15.7	1.5	1.8	-4.0	2.5