Hub : Genes

PRDX1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0380	3.3e-03	0.008	0.029	0.012	0.029	0.019	3.5e-02	1.7e-04	1.1e-02	1.7e-04	2.0e-03
2	GTEx	Adipose Subcutaneous	0.0770	0.0410	4.9e-05	0.056	NA	0.096	NA	0.090	2.1e-05	NA	3.0e-08	NA	7.7e-08
3	GTEx	Artery Aorta	0.1200	0.0550	4.3e-04	0.093	NA	0.069	NA	0.053	8.5e-06	NA	1.2e-04	NA	6.5e-04
4	GTEx	Artery Tibial	0.1963	0.0763	2.4e-09	0.159	NA	0.198	NA	0.198	1.6e-12	NA	2.1e-15	NA	1.8e-15
5	GTEx	Cells Transformed fibroblasts	0.1920	0.0960	4.4e-05	0.154	NA	0.124	NA	0.149	1.2e-11	NA	1.4e-09	NA	2.6e-11
6	GTEx	Lung	0.0687	0.0330	1.5e-04	0.061	NA	0.054	NA	0.053	2.1e-05	NA	5.3e-05	NA	6.4e-05
7	GTEx	Testis	0.2150	0.1220	4.0e-03	-0.002	NA	0.053	NA	0.003	4.0e-01	NA	2.2e-03	NA	2.2e-01
8	GTEx	Thyroid	0.2280	0.0600	1.1e-16	0.257	NA	0.263	NA	0.284	1.1e-19	NA	3.4e-20	NA	6.1e-22
9	YFS	Blood	0.1634	0.0385	0.0e+00	0.057	0.097	0.113	0.108	0.113	4.0e-18	7.0e-30	7.3e-35	2.6e-33	4.8e-35
10	TCGA	Thyroid Carcinoma	0.1770	0.0570	0.0e+00	0.201	0.270	0.271	NA	0.275	2.8e-19	2.9e-26	2.1e-26	NA	7.9e-27

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.4	2.3	3.5	1.3	-1.9	-1.5	-1.8	-1.6	-1.6	0.6	-1.1	-1.7	-1.5
Bipolar Disorder or Schizophrenia	0.4	0.9	1.8	0.5	-0.7	-0.6	-0.8	-0.5	-1.1	-1.2	-0.9	-1.4	-1.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-1.3	0.3	-0.4	-0.0	-0.3	1.0	-0.6	1.4	0.5	1.2
Depression (Nagel 2018)	0.6	1.0	2.6	-1.3	0.5	0.3	0.5	0.1	0.9	-1.2	1.6	0.4	1.6
Intelligence (Savage-Jansen 2018)	1.7	5.2	12.9	1.8	-1.7	-1.9	-1.7	-1.2	-3.3	3.6	-2.8	-1.0	-2.2
Neuroticism (Nagel 2018)	0.1	0.3	1.3	-1.1	0.1	-0.6	-0.2	-0.0	0.1	0.1	0.6	0.4	0.6
Schizophrenia (2018)	0.3	0.6	4.2	-0.4	0.7	0.5	0.5	0.7	-0.0	-2.0	-0.3	-0.4	-0.5
Schizophrenia vs Biploar Disorder	1.3	1.7	6.0	-2.4	1.2	0.5	0.9	0.7	1.6	-0.2	0.9	1.6	1.3
Worry (Nagel 2018)	0.6	1.3	2.0	-1.4	1.4	0.4	0.9	1.0	1.1	0.4	1.4	1.3	1.3
Alzheimer’s Disease (in mother)	0.9	1.0	5.6	-1.2	-0.1	-0.7	-0.8	-0.6	0.7	-2.4	0.1	-1.1	-0.0
Alzheimer’s Disease (in father)	1.1	1.2	6.0	-0.1	1.1	1.7	0.7	0.9	0.9	-2.4	0.5	-0.0	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.5	11.8	-0.6	0.4	0.4	-0.3	0.1	1.0	-3.4	-0.0	-1.1	-0.6
Crohns Disease (2017)	1.1	2.4	17.6	-4.2	0.1	-1.5	-0.5	-0.2	1.4	-0.7	0.6	-0.3	0.9
Irritable Bowel Disease (IBD)	1.7	4.0	15.1	-3.9	-1.5	-3.3	-2.2	-1.9	-0.0	-0.3	-0.9	-1.4	-0.3
Ulcerative Colitis (UC)	2.9	5.4	15.6	-2.4	-2.4	-4.0	-3.0	-2.9	-1.1	-0.1	-1.9	-2.0	-1.3
Major Depression (MDD)	0.7	0.9	3.0	0.2	1.2	1.4	0.8	1.7	0.2	0.8	-0.6	0.4	-0.8
Reaction Time	0.5	1.0	4.3	-2.1	-0.8	-1.2	-1.1	-1.2	0.7	0.0	0.5	-0.4	0.2
Verbal and Numeric Reasoning (VNR)	2.2	5.2	17.9	1.5	-1.9	-2.1	-1.6	-1.4	-2.9	4.2	-2.7	-0.6	-1.9
Breast Cancer	5.8	14.1	22.8	0.2	-4.2	-4.8	-4.1	-3.7	-4.7	2.7	-4.0	-3.0	-3.9
Ovarian Cancer	0.5	0.7	2.6	1.6	0.7	0.8	0.8	1.0	-0.5	0.9	-0.3	0.6	-0.1
Prostate Cancer	2.4	3.3	8.8	-2.3	1.6	0.9	1.5	1.0	3.0	-0.6	1.8	1.8	2.4
Age at First Birth	0.5	0.7	2.2	-0.7	-0.6	-1.0	-0.3	-0.1	-1.5	1.3	-0.7	-0.1	-0.9
Bipolar Disorder (2011)	1.7	1.7	3.9	-0.2	-1.4	-1.7	-2.0	-1.4	-0.9	0.7	-0.8	-1.7	-1.0
Body Mass Index (BMI) (2010)	0.8	1.1	5.1	0.7	1.0	1.1	1.0	0.9	0.8	-2.3	0.8	0.1	0.5
Coronary Artery Disease (CAD)	0.4	0.5	2.8	0.3	-0.4	-0.3	-0.4	-0.5	0.8	-1.7	0.3	-0.7	0.4
Crohns Disease (2012)	0.8	1.3	8.9	-3.0	0.5	-0.8	-0.5	0.1	0.9	-1.2	0.9	-0.4	0.4
Mean Putamen Volume	0.1	0.1	0.6	-0.3	-0.2	-0.8	0.1	-0.3	-0.3	-0.3	-0.1	0.0	0.4
Fasting Glucose	3.1	3.7	6.8	-1.4	2.4	1.5	1.6	2.1	2.4	-2.6	2.0	0.8	1.5
HbA1C	0.6	0.7	1.4	-0.7	0.9	0.6	0.9	1.2	1.1	-0.1	0.4	0.8	0.7
HDL Cholesterol	0.3	0.5	1.4	0.8	0.4	0.3	-0.2	0.3	-0.6	-1.2	-0.4	-0.9	-0.9
LDL Cholesterol	0.4	0.6	3.6	1.1	-0.6	0.3	-0.2	-0.1	-0.3	1.9	-0.8	0.1	-0.3
Lupus	1.3	1.9	5.2	0.7	-1.2	-1.2	-1.3	-0.7	-2.3	1.7	-1.6	-0.9	-1.4
Neuroticism (2016)	1.9	2.8	5.1	-0.5	-1.3	-2.1	-2.3	-1.5	-2.0	-0.2	-1.8	-1.9	-1.9
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.9	0.6	0.1	0.1	0.8	0.7	-0.7	0.2	-0.0	-0.0
Rheumatoid Arthritis	1.8	2.5	4.6	1.5	1.5	1.2	1.8	1.3	1.5	-0.2	2.0	2.0	2.1
Schizophrenia (2014)	0.2	0.5	1.8	-0.9	1.0	0.4	0.6	0.9	0.2	-1.3	0.2	0.1	-0.1
Triglycerides	0.1	0.2	0.6	-0.2	0.2	0.3	0.3	0.1	0.5	0.5	0.1	0.7	0.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	5.1	-0.5	1.7	0.9	0.8	1.2	2.2	-2.2	1.5	0.3	1.1
Ulcerative Colitis	3.6	5.2	10.8	-0.9	-2.5	-3.3	-3.0	-2.7	-2.0	0.7	-2.1	-2.4	-1.7
Blood Eosinophil Count	0.7	5.5	10.9	-1.1	2.1	2.0	2.6	1.3	3.3	-0.9	2.7	2.9	3.0
Blood Platelet Count	16.5	190.7	289.0	-3.6	17.0	14.0	14.0	13.8	15.4	-15.9	16.5	10.0	12.7
Blood Red Count	3.4	33.3	96.4	-4.9	-7.8	-6.9	-4.9	-7.2	-3.6	9.8	-4.0	-0.2	-0.5
Blood White Count	1.8	13.5	34.2	-4.7	1.2	0.0	2.3	-0.5	5.8	0.4	4.8	3.9	5.8
Heel T-Score	1.1	8.5	17.0	2.1	-2.9	-1.8	-2.8	-1.8	-3.8	3.1	-4.1	-2.4	-3.4
BMI	0.4	2.4	17.2	0.7	0.6	-0.1	0.3	-0.2	1.0	-4.2	1.4	-1.0	1.5
Height	0.8	15.1	34.3	-4.6	-5.1	-5.9	-3.9	-4.9	-2.0	4.8	-1.0	-1.4	-0.2
Waist Hip Ratio (WHR)	0.3	1.2	5.1	2.2	-0.2	1.5	0.9	0.4	-0.9	1.3	-0.5	1.0	-0.2
Systolic Blood Pressure	1.5	7.6	16.6	-0.2	3.5	3.7	2.4	3.0	2.6	-4.1	3.0	0.9	1.6
Smoking Status	3.1	7.4	11.0	0.9	3.0	3.2	3.0	2.4	3.2	-2.8	3.3	1.8	2.6
Allergy or Eczema	0.5	1.3	8.5	2.9	0.7	1.2	0.3	0.9	-0.9	0.1	-0.4	-0.1	-0.8
Cardiovascular Disease	1.4	4.6	9.0	-0.1	1.9	2.4	2.2	1.1	1.9	-3.0	3.0	1.7	2.5
Hypothyroidism (self reported)	0.6	1.3	2.1	1.4	1.4	0.8	1.3	1.1	1.2	-1.0	1.2	0.8	1.1
Respiratory disease	0.7	1.7	5.0	2.2	-0.1	0.6	-0.4	0.0	-2.2	0.5	-1.5	-1.0	-1.7
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.6	0.7	0.6	1.1	0.8	0.5	1.6	-1.5	1.5	0.5	1.3
Lung FEV1/FVC ratio	2.0	10.3	62.4	-1.2	3.5	1.2	1.0	2.3	2.2	-7.9	3.2	-1.4	1.4
Lung FVC	0.4	1.9	7.9	-1.8	0.4	-0.7	0.0	-0.4	2.8	-0.8	1.7	0.2	1.8
Neuroticism	0.2	0.5	1.3	-0.8	-0.4	-1.1	-0.4	-0.4	-0.8	1.1	-0.0	0.6	0.0
Chronotype (morning person)	0.9	2.2	5.1	1.5	-1.5	-1.1	-1.0	-1.6	-2.3	0.9	-1.8	-1.0	-1.5
Hair Pigment	0.1	2.5	5.6	-2.1	1.4	0.2	1.4	0.8	2.4	-0.8	2.1	1.1	2.1
Tanning	0.0	0.4	2.0	0.1	-0.2	-0.0	-0.4	-0.1	-0.1	-1.4	-0.2	-0.9	-1.0
Hand grip strength (left)	0.7	1.9	3.1	0.2	-1.8	-1.6	-1.6	-1.5	-1.4	0.8	-1.5	-1.3	-1.5
Number of treatments/medications taken	2.1	3.7	12.5	2.0	2.2	3.5	1.8	2.4	0.9	-2.1	0.9	0.6	-0.0
Average weekly spirits intake	0.5	0.7	2.1	0.6	-0.6	-0.8	-1.0	-0.7	-0.1	-1.4	-0.4	-1.3	-0.3
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.3	0.1	-0.1	-0.1	0.8	-0.9	0.8	-0.9	0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.9	-0.3	0.2	0.7	0.6	0.1	1.1	-0.5	1.2	0.7	1.4
Hearing difficulty/problems: Yes	3.7	5.6	11.3	-1.0	-2.6	-3.3	-2.0	-2.4	-3.4	2.8	-2.3	-1.1	-1.5
Relative age of first facial hair	0.4	0.8	3.2	-1.8	0.1	-0.2	0.2	0.1	1.2	-0.9	1.1	0.5	0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.5	0.9	1.5	1.1	1.5	1.3	0.7	0.2	1.2	1.6	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	1.0	1.1	1.4	0.7	1.4	-0.7	-0.7	-0.0	-0.2	-0.5
Ever had hysterectomy (womb removed)	3.3	3.8	7.5	-0.1	2.0	2.3	2.1	1.7	2.2	-2.7	2.1	1.2	1.9
Systolic blood pressure, automated reading	1.7	5.0	11.5	0.9	3.1	3.4	2.0	3.2	1.4	-3.1	1.5	0.3	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.2	-0.8	-0.6	-0.1	-0.6	-0.7	0.7	-1.0	0.3	-0.6
Angina	1.8	2.3	4.1	0.0	1.6	1.7	2.0	1.6	1.1	0.3	1.6	1.9	1.9
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.4	-0.4	0.2	0.2	-0.2	-0.2	0.1
Vitamin and mineral supplements	1.1	1.6	4.0	-1.0	-0.7	-1.2	0.3	-1.2	0.5	2.0	0.9	1.7	1.8
Supplements: Zinc	2.0	2.2	3.5	1.4	1.3	1.9	1.5	1.2	1.4	-1.7	1.9	0.9	1.2
Medication: Co-codamol	0.1	0.2	0.3	0.1	0.2	0.6	0.5	0.4	0.6	-0.4	0.2	0.2	0.2
Medication: Metformin	0.7	1.0	5.9	2.4	0.1	1.1	0.6	0.6	-0.5	0.7	-0.8	0.4	-0.9
Diabetes (father)	0.8	0.9	2.8	-0.1	0.6	0.4	0.9	0.3	1.5	-0.6	1.2	1.1	1.7
Diabetes (mother)	1.2	1.5	4.9	-0.3	1.2	1.1	0.9	0.8	1.3	-2.2	1.7	0.4	1.0
Severe depression (siblings)	1.3	1.4	4.1	0.2	-1.2	-0.2	-1.6	-0.9	-1.0	-1.1	-0.7	-2.0	-1.6
Pack years adult smoking proportion	1.9	3.0	5.9	0.5	1.9	2.2	2.4	2.0	1.2	-0.6	1.4	2.3	1.5
Impedance of leg (right)	0.7	3.2	6.5	-0.3	2.2	2.2	2.1	2.1	1.6	1.0	1.4	2.5	1.4
Leg fat-free mass (left)	0.4	2.2	5.1	-0.3	-2.1	-2.2	-1.7	-2.0	-1.5	0.1	-0.6	-1.5	-0.3
Trunk fat percentage	0.6	2.4	5.7	0.4	1.1	1.2	1.5	0.7	1.7	-2.3	2.1	0.9	2.4
Hand grip strength (right)	1.0	2.7	4.6	0.8	-1.8	-1.8	-1.6	-1.4	-2.1	1.0	-1.9	-1.5	-1.9
Townsend deprivation index at recruitment	0.5	0.7	1.2	0.8	0.8	0.9	0.9	0.9	0.4	0.9	0.7	1.1	0.9
Current tobacco smoking	3.7	6.1	11.6	0.7	2.9	3.4	2.8	2.4	2.5	-3.1	2.5	1.3	1.8
Average weekly fortified wine intake	2.1	2.4	4.5	1.3	-1.8	-1.5	-1.6	-1.6	-2.1	0.0	-1.5	-1.7	-1.5
Maternal smoking around birth	1.5	2.2	6.6	1.2	1.4	2.6	1.6	1.1	1.5	-1.5	1.3	1.1	0.9
Fed-up feelings	0.7	1.2	3.0	-0.7	1.1	0.7	0.9	0.9	1.4	-0.2	1.7	1.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.8	-1.1	0.1	-0.0	0.0	-0.3	0.8	-1.7	1.5	-0.2	1.3
Relative age voice broke	0.8	1.2	2.8	-1.2	0.7	0.2	0.8	0.4	1.4	0.6	1.3	1.5	1.7
Taking other prescription medications	2.0	3.1	6.3	0.5	2.5	2.3	2.1	2.4	1.7	-1.4	1.3	1.3	0.9
Age when periods started (menarche)	2.4	5.7	9.5	-1.1	2.9	2.1	3.1	2.9	1.9	-0.2	2.4	3.0	2.5
Bilateral oophorectomy (both ovaries removed)	4.8	5.6	8.4	-1.9	2.9	2.3	2.7	2.9	2.5	-0.4	2.3	2.4	2.4
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	8.4	2.1	-2.2	-1.0	-2.1	-1.6	-2.9	1.0	-2.9	-2.1	-2.5
Tinnitus: Yes, but not now, but have in the past	3.3	3.6	6.4	-1.2	2.5	1.5	2.1	1.8	1.9	-1.4	2.2	1.8	1.9
Qualifications: CSEs or equivalent	0.7	0.9	2.5	-0.6	0.5	0.9	0.5	-0.0	1.6	-1.5	1.1	0.3	1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.1	0.0	0.5	1.0	0.8	0.6	0.5	0.8	1.0	1.0	0.9
High blood pressure	1.2	3.2	8.0	-0.6	1.9	2.1	1.6	1.3	1.1	-2.8	2.5	0.9	1.8
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.8	2.2	0.7	1.4	0.7	0.9	-0.6	-0.3	0.4	0.2	0.0
Multivitamins +/- minerals	1.2	1.5	4.0	2.0	0.5	1.3	-0.4	0.9	-0.4	-1.4	-0.9	-1.5	-1.7
Stomach or abdominal pain in last month	0.6	0.7	1.5	1.2	1.1	0.9	1.0	0.5	0.1	-1.2	0.7	0.4	0.6
Supplements: Glucosamine	2.0	2.6	13.4	0.8	1.6	1.9	1.2	1.4	1.1	-3.7	0.9	-0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.4	0.8	0.0	0.0	-0.1	-0.1	-1.2	-0.5	-0.3	-0.3	-0.9
Medication: Atenolol	0.1	0.2	0.4	-0.6	0.6	-0.2	0.2	0.5	-0.1	-0.5	0.5	-0.1	0.1
Medication: Levothyroxine sodium	0.6	1.0	2.0	1.2	1.1	0.9	1.1	1.0	1.0	-1.4	0.7	0.7	0.6
Sitting height	0.9	6.2	16.2	-4.0	-2.5	-3.3	-2.0	-2.8	-0.6	3.8	0.5	0.1	1.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.1	1.0	-0.9	-0.3	-0.8	-0.9	-1.4	-1.4	-0.8	-1.3	-0.9
High blood pressure (mother)	1.0	1.4	3.7	0.5	1.3	1.9	1.2	1.1	0.7	-1.6	1.2	0.6	1.0
Body mass index (BMI)	0.5	2.0	11.4	0.9	1.0	0.5	0.8	0.4	1.0	-3.4	1.4	-0.3	1.5
Impedance of leg (left)	0.5	2.7	6.1	-0.4	1.7	1.9	2.0	1.8	1.4	1.4	1.0	2.5	1.2
Leg predicted mass (left)	0.4	2.1	5.0	-0.4	-2.1	-2.2	-1.7	-2.0	-1.4	-0.0	-0.6	-1.6	-0.2
Trunk fat mass	0.4	1.6	4.6	0.1	0.6	0.5	1.0	0.2	1.3	-2.1	1.8	0.4	2.1
Waist circumference	0.2	0.8	3.6	1.9	-0.5	0.1	-0.0	-0.5	-0.8	-1.8	-0.1	-0.8	0.1
Number of incorrect matches in round	0.2	0.3	0.7	-0.7	0.8	0.3	0.7	0.6	0.4	0.3	0.3	0.8	0.4
Past tobacco smoking	1.6	2.9	4.9	-1.3	-1.9	-1.8	-1.8	-1.5	-1.7	1.0	-2.2	-1.2	-2.0
Alcohol usually taken with meals	0.6	1.0	2.2	-1.0	-1.3	-1.4	-1.2	-1.5	0.4	0.1	0.4	-0.7	0.6
Nervous feelings	0.3	0.6	2.4	-1.5	-0.0	-1.2	-0.9	-0.2	-0.5	0.0	-0.4	-0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.3	0.2	0.1	0.0	-0.1	0.2	-0.6	-0.0	-0.1	-0.1	-0.0
Hearing difficulty/problems with background noise	0.4	0.6	2.8	-1.7	-0.4	-0.9	-0.5	-0.4	-0.7	1.4	-0.1	0.1	-0.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.8	0.5	-0.1	-0.5	-0.4	-0.0	-1.0	0.6	-1.0	-0.4	-1.3
Had menopause	1.7	2.1	6.5	1.4	-1.0	-0.3	-1.1	-0.7	-2.5	0.7	-1.8	-1.2	-2.1
Had other major operations	2.2	2.7	6.0	1.0	2.1	2.0	2.2	2.4	0.8	-0.3	1.2	1.9	0.7
Forced vital capacity (FVC)	0.3	1.1	2.4	-1.6	-0.5	-1.3	-0.4	-0.9	1.0	1.2	1.2	0.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.6	1.4	-1.1	-0.2	-1.1	-0.5	-1.6	0.5	-1.6	-1.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.7	-0.7	-0.5	-0.6	-0.4	-0.5	0.0	-0.6	-0.5	-0.6
Qualifications: None of the above	2.0	4.3	7.7	0.0	2.2	1.9	2.8	2.3	1.6	-0.1	2.3	2.6	2.5
Financial difficulties in last 2 years	1.3	1.7	3.0	0.5	1.4	1.5	1.7	1.4	0.9	-0.9	1.6	1.3	1.5
Mouth/teeth dental problems	1.8	2.8	5.3	1.0	-1.9	-0.9	-1.2	-1.4	-2.1	1.8	-2.2	-1.0	-2.3
Heart attack	0.2	0.2	0.6	0.0	-0.0	0.6	0.7	0.3	0.2	0.1	0.3	0.6	0.7
Allergy	0.6	1.3	7.3	-2.7	-0.8	-1.7	-0.7	-1.0	1.0	-0.0	-0.2	-0.2	0.1
Pain all over the body in last month	1.1	1.1	2.9	0.1	1.2	0.8	1.2	0.8	0.4	-0.2	1.5	1.3	1.7
Diabetes (self-reported)	0.9	1.4	4.0	1.3	0.9	2.0	1.3	1.2	1.5	-0.2	0.7	1.1	0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	6.0	2.5	1.1	1.6	0.6	1.4	-1.0	0.3	-0.6	-0.1	-1.1
Medication: Ramipril	0.3	0.4	0.8	-0.6	0.4	0.5	0.5	0.8	0.2	-0.1	0.9	0.7	0.7
Medication: Simvastatin	2.2	3.3	5.9	0.1	2.3	1.9	2.4	2.2	1.4	0.6	1.6	2.4	1.6
Fluid intelligence score	2.0	4.1	12.5	2.2	-1.6	-1.2	-1.3	-1.1	-2.5	3.5	-2.4	-0.8	-2.0
Illnesses of siblings	0.3	0.4	1.5	0.6	-0.2	-0.3	-0.1	-0.3	-0.3	1.2	-1.2	0.1	-1.0
Neuroticism score	0.2	0.4	1.1	-0.9	0.4	-0.1	0.4	0.6	0.2	0.6	0.7	1.1	0.6
Weight	0.1	0.5	1.6	-0.2	-0.4	-0.9	-0.2	-0.8	0.0	-1.1	0.9	-0.4	1.3
Impedance of arm (right)	0.5	2.1	6.7	-0.5	0.7	1.3	1.5	0.9	1.0	2.6	0.9	2.5	1.1
Arm fat percentage (right)	0.7	2.8	7.7	1.0	1.3	1.3	1.6	0.9	1.5	-2.8	2.1	0.7	2.2
Trunk fat-free mass	0.2	1.4	3.7	-0.6	-1.4	-1.9	-1.4	-1.3	-1.4	0.5	-0.5	-1.3	-0.3
Hip circumference	0.2	0.8	1.8	0.6	-1.0	-1.0	-0.9	-1.1	-0.8	-0.9	-0.5	-1.4	-0.1
Time employed in main current job	0.7	0.8	2.1	-1.3	-0.3	-0.8	0.4	-0.7	0.8	0.6	0.9	1.1	1.5
Alcohol intake versus 10 years previously	0.3	0.4	2.3	1.5	-0.1	0.9	0.4	0.0	-1.0	0.4	-0.1	-0.1	0.0
Father’s age at death	0.5	0.6	1.4	-0.7	-0.9	-1.2	-1.0	-0.8	-0.5	0.7	-0.7	-0.5	-0.4
Worrier / anxious feelings	1.3	2.4	4.8	-1.1	2.2	1.8	1.6	2.2	1.2	-0.5	1.6	1.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.8	0.4	0.4	0.5	0.4	0.5	0.0	0.6	0.4	0.7
Falls in the last year	0.2	0.3	2.2	1.5	-0.2	0.9	0.1	-0.0	-0.2	-0.4	-0.2	-0.1	-0.1
Hair/balding pattern: Pattern 3	3.4	5.1	7.9	-0.7	2.8	2.7	2.6	2.3	2.6	-0.5	2.4	2.3	2.2
Number of live births	0.8	1.2	7.9	-1.0	0.2	-0.1	-0.4	-0.2	1.2	-2.8	0.7	-0.8	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.0	-1.7	0.7	-0.6	-0.1	-0.2	1.9	-1.8	2.5	-0.1	1.8
Pulse rate	0.2	0.4	1.4	-0.7	-0.8	-0.5	-0.4	-1.2	-0.5	-0.0	-0.5	-0.0	-0.3
Happiness	0.3	0.4	1.5	1.2	0.6	0.8	0.3	0.6	-0.8	0.3	0.0	0.1	-0.5
Noisy workplace	0.0	0.1	0.4	0.6	0.1	0.0	-0.1	0.2	-0.1	-0.1	0.0	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.6	1.1	-1.8	-1.4	-1.3	-1.6	-2.0	2.1	-1.9	-0.7	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	7.3	2.7	0.1	0.9	-0.1	0.3	-1.9	-1.1	-1.2	-1.4	-1.7
Mouth/teeth dental problems: Dentures	3.6	6.1	10.1	-1.8	2.8	2.1	2.3	2.2	3.1	-1.6	3.0	2.1	3.2
Asthma	0.4	0.8	2.4	1.5	0.3	0.7	-0.4	0.2	-1.5	-0.1	-0.8	-1.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.7	0.2	-0.0	-0.0	-0.2	0.8	-0.3	0.9	-0.1	0.6
Medication: Cholesterol lowering	1.3	2.0	3.6	-0.9	1.2	1.1	1.5	1.1	1.9	-0.1	1.8	1.6	1.9
Depression (self-reported)	0.3	0.4	1.1	-0.2	1.0	0.8	0.8	0.9	0.0	-0.5	0.1	0.3	-0.2
Medication: Lansoprazole	0.8	0.9	1.6	1.1	-1.0	-0.3	-1.0	-0.8	-1.3	0.2	-0.7	-1.2	-1.1
Prospective memory result	0.5	0.6	1.3	0.8	-0.8	-0.6	-0.5	-0.5	-1.2	0.3	-1.1	-0.3	-1.1
Lung cancer (father)	1.7	2.0	4.5	0.7	1.9	2.1	1.9	1.9	0.5	-1.3	0.9	1.1	0.5
Illnesses of mother	0.8	1.0	6.7	-1.1	-0.3	-0.7	-0.3	0.1	-0.4	2.6	-0.7	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.3	-1.8	-0.0	-1.3	-0.6	-0.8	1.0	-1.2	1.6	-0.4	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-0.1	0.6	0.4	0.3	0.0	1.2	-0.8	1.4	0.4	0.9
Impedance of arm (left)	0.3	1.6	5.8	-0.2	0.5	1.3	1.3	0.8	0.6	2.4	0.7	2.1	0.8
Arm fat mass (right)	0.3	1.3	5.2	0.8	0.6	0.5	0.8	0.3	0.8	-2.3	1.5	0.0	1.7
Trunk predicted mass	0.2	1.3	3.5	-0.5	-1.4	-1.9	-1.4	-1.3	-1.4	0.5	-0.4	-1.2	-0.2
Standing height	0.6	6.1	20.3	-2.3	-2.8	-3.2	-2.2	-2.6	-2.0	4.5	-0.9	-0.4	-0.2
Length of working week for main job	2.4	2.7	6.2	0.3	1.6	1.3	1.7	1.0	1.8	-0.8	2.5	1.6	2.4
Exposure to tobacco smoke at home	0.4	0.4	1.1	0.9	0.5	0.8	0.7	1.0	-0.1	0.6	-0.5	0.5	-0.2
Breastfed as a baby	0.3	0.4	1.4	1.2	-0.4	0.4	-0.2	-0.1	-0.6	0.1	-0.9	-0.5	-0.8
Tense / ‘highly strung’	0.7	1.1	3.0	-1.3	1.0	0.5	0.7	0.8	0.8	0.0	1.6	1.1	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.7	0.1	0.3	-0.0	-0.0	-0.0	-0.8	-0.4	-0.1	-0.2	0.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-1.4	-0.2	-0.8	-0.2	-1.2	1.0	-1.5	0.8	0.1	1.5
Birth weight of first child	0.6	1.1	4.6	-0.4	-0.4	-0.8	0.2	-0.7	0.2	2.1	0.9	1.3	1.4
Peak expiratory flow (PEF)	0.4	1.0	3.2	1.8	-0.2	-0.1	-0.8	-0.6	-0.6	-1.7	0.2	-1.6	-0.6
Pulse wave reflection index	0.3	0.4	1.3	-0.2	0.7	0.3	-0.1	0.4	1.1	-1.0	0.9	-0.3	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.5	1.6	-1.0	-0.6	-0.4	-0.8	-0.2	0.2	-0.5	-0.3	-0.4
Loud music exposure frequency	0.5	0.6	1.6	1.1	-0.7	-0.6	-0.5	-0.6	-1.3	0.2	-0.8	-0.7	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.1	0.5	-1.4	-0.9	-1.0	-1.3	-1.1	0.8	-1.0	-0.7	-0.7
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	5.3	-0.6	1.7	0.6	1.3	1.1	2.1	-0.1	2.1	1.7	2.3
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.1	0.7	0.7	0.7	0.8	0.0	-1.1	0.2	0.3	0.1
Medication: Paracetamol	0.6	1.0	4.9	1.1	0.3	1.2	-0.1	0.3	-0.1	-2.2	-0.4	-0.9	-1.1
Headache pain in last month	0.6	1.0	2.5	0.5	1.2	1.6	0.6	0.8	0.6	-1.2	1.4	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	4.9	1.0	-1.6	-2.0	-1.5	-1.3	-2.0	1.9	-2.2	-1.1	-1.8
Glaucoma (self-reported)	3.4	4.0	6.0	-0.2	2.5	2.4	2.4	2.4	1.9	-0.6	2.1	2.3	1.9
Gout (self-reported)	0.3	0.4	1.0	0.9	0.3	0.8	0.7	0.4	0.5	0.7	-0.1	1.0	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.7	1.3	1.2	0.7	0.8	1.0	0.8	-0.9	0.4	0.3	0.3
Medication: Amlodipine	0.8	1.1	1.7	-1.2	1.2	0.6	1.2	0.9	0.8	0.6	1.1	1.3	1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.7	1.0	1.2	0.5	0.9	0.2	-1.1	-0.1	0.2	-0.3
Birth weight	0.5	1.2	7.9	0.3	-0.3	-0.3	0.3	-0.1	0.0	2.8	0.4	1.4	1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.6	-0.6	0.7	0.4	0.7	0.1	1.6	-2.4	1.3	0.5	1.1
High blood pressure (siblings)	1.1	1.5	6.1	-0.7	0.9	1.4	0.6	0.9	0.9	-2.5	1.7	-0.0	0.9
Forced vital capacity (FVC), Best measure	0.3	1.3	3.7	-1.9	-0.9	-1.8	-0.8	-1.2	0.5	1.2	0.6	0.1	0.9
Body fat percentage	0.8	3.0	7.2	0.6	1.3	1.3	1.6	0.8	1.8	-2.7	2.2	0.9	2.5
Leg fat percentage (right)	1.6	5.9	12.9	0.6	2.5	2.0	2.4	1.9	2.6	-3.6	2.9	1.4	3.0
Arm fat-free mass (right)	0.4	1.9	3.9	-0.1	-1.6	-2.0	-1.7	-1.6	-1.7	-0.3	-0.7	-1.8	-0.5
Exposure to tobacco smoke outside home	2.1	2.8	5.4	0.4	2.3	1.4	1.6	1.9	2.1	-1.8	2.0	0.9	1.4
Comparative body size at age 10	0.5	1.3	4.8	1.6	1.1	1.4	0.8	1.3	0.2	-2.2	0.4	-0.2	-0.0
Number of full brothers	0.3	0.4	1.8	-1.3	0.5	0.6	0.2	0.5	0.9	-0.3	0.4	0.1	0.2
Worry too long after embarrassment	1.4	2.4	5.8	-1.0	-2.1	-2.4	-1.9	-1.5	-1.3	1.3	-1.2	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	3.3	0.2	1.7	1.4	1.8	1.5	0.7	-1.6	1.6	1.4	1.2
Wheeze or whistling in the chest in last year	1.3	2.3	6.5	2.5	1.7	2.0	1.6	1.1	-0.2	-2.2	0.5	0.7	0.4
Number of children fathered	1.5	1.7	4.2	-0.4	1.0	0.9	0.8	0.4	1.9	-2.0	2.0	0.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	4.8	-2.2	-0.3	-1.1	-0.1	-0.7	0.5	-1.4	0.3	0.2	0.5
Age at first live birth	0.6	1.0	3.3	-0.4	-1.1	-1.5	-1.1	-1.3	-0.4	1.8	-0.4	-0.3	-0.0
Pulse wave peak to peak time	0.6	0.7	1.9	0.1	-0.6	-0.4	-0.3	-0.1	-1.4	1.1	-1.4	-0.4	-0.9
Health satisfaction	0.2	0.3	0.9	0.7	-0.0	1.0	0.4	0.0	0.3	-0.4	0.8	0.2	0.6
Shortness of breath walking on level ground	3.3	3.9	7.1	-0.5	-2.6	-2.2	-2.6	-2.7	-1.7	0.9	-2.0	-1.8	-1.4
Qualifications: College or University degree	4.6	14.6	22.9	-0.0	-4.8	-4.8	-4.4	-4.7	-3.9	3.3	-3.9	-3.1	-3.0
Eye problems/disorders: None of the above	0.4	0.5	1.1	-1.1	-0.1	-0.8	-0.3	-0.3	1.0	0.0	0.9	-0.2	0.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.0	-0.9	0.9	0.7	0.4	0.3	1.4	-1.7	1.0	0.1	1.1
Emphysema/chronic bronchitis	1.1	1.2	2.3	-0.3	1.2	1.5	1.0	1.1	1.5	-0.9	1.4	0.5	0.8
Medication for pain relief, constipation, heartburn	0.3	0.4	1.5	-0.6	-0.3	-0.8	0.2	-0.3	0.3	1.2	0.3	0.9	0.8
Neck or shoulder pain in last month	1.5	2.2	4.1	0.0	1.7	2.0	1.6	1.5	1.2	-1.3	1.9	1.0	1.4
Medication: Blood pressure	1.6	2.7	5.5	-1.3	1.5	1.8	1.2	1.1	1.9	-2.3	2.3	0.7	1.7
Angina (self-reported)	1.6	2.1	3.7	-0.2	1.6	1.4	1.9	1.4	1.1	0.4	1.6	1.9	1.9
Migraine (self-reported)	0.9	1.1	2.5	-1.4	1.1	1.2	0.4	1.0	1.6	-0.7	1.3	0.3	0.8
Medication: Ibuprofen	0.5	0.6	1.7	-0.0	0.8	0.8	0.7	0.3	0.7	-1.3	1.1	0.2	0.5
Medication: Allopurinol	0.5	0.6	2.0	1.1	0.0	0.8	0.8	0.1	0.6	1.1	-0.3	1.4	0.2
Medication: Omeprazole	0.3	0.3	0.6	-0.4	0.8	0.5	0.2	0.8	0.8	-0.8	0.2	-0.2	-0.0
Medication: Seretide 50 evohaler	0.5	0.6	1.6	1.0	-0.0	-0.0	-0.2	-0.1	-1.0	0.7	-1.2	-0.3	-1.3
Mean time to correctly identify matches	1.0	2.0	8.2	-2.9	-1.1	-2.1	-1.6	-1.6	0.4	0.4	0.2	-0.8	0.1
Heart disease (mother)	1.1	1.3	3.2	0.9	-1.0	-0.9	-1.2	-0.9	-1.5	-0.7	-1.0	-1.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.8	1.8	1.0	1.9	1.2	0.8	1.3	-0.9	1.1	0.8	0.9
Whole body fat mass	0.3	1.2	5.0	0.3	0.4	0.3	0.7	0.1	1.1	-2.2	1.5	0.1	1.8
Leg fat mass (right)	0.5	2.0	8.5	0.3	1.0	0.6	1.0	0.4	1.4	-2.9	1.8	0.2	1.9
Arm predicted mass (right)	0.5	2.3	5.1	-0.3	-1.9	-2.3	-1.8	-1.8	-1.8	0.2	-0.9	-1.8	-0.7
Pulse rate, automated reading	0.4	1.3	4.1	-1.3	0.5	0.7	1.6	-0.0	0.2	-0.3	1.3	2.0	1.6
Alcohol intake frequency.	0.2	0.4	1.3	0.5	-0.6	-0.1	-0.4	-0.6	-1.1	0.7	-0.7	-0.6	-0.6
Comparative height size at age 10	0.9	5.0	20.2	-0.2	-2.8	-1.9	-1.8	-2.0	-2.6	4.5	-1.8	-0.3	-0.9
Number of full sisters	0.5	0.6	3.2	1.8	0.3	1.3	0.8	0.3	-0.5	0.1	-0.1	0.5	0.2
Suffer from ‘nerves’	2.6	4.0	5.9	0.2	2.4	1.9	2.3	1.9	2.4	-1.3	2.4	2.0	2.2
Overall health rating	2.6	5.6	8.5	-0.5	2.6	2.3	2.8	2.3	2.6	-0.6	2.9	2.6	2.9
Chest pain or discomfort	1.0	1.4	3.2	1.6	0.8	1.8	1.2	0.8	0.5	-1.6	1.3	0.4	1.1
Had major operations	4.4	5.1	8.1	0.9	2.4	2.7	2.3	1.9	2.5	-2.7	2.9	1.3	2.2
Age at last live birth	0.4	0.6	1.9	-0.5	-0.8	-1.3	-0.8	-1.4	0.0	0.0	0.4	-0.3	0.5
Family relationship satisfaction	0.3	0.4	0.9	-1.0	-0.3	-0.8	-0.7	-0.6	0.7	-0.2	0.7	-0.2	0.5
Leg pain on walking	0.2	0.3	0.8	0.5	0.1	0.1	0.5	-0.0	0.5	0.4	0.8	0.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.8	-0.3	1.2	0.7	1.0	0.8	2.0	-1.4	1.2	0.6	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.5	-0.2	0.8	0.4	1.6	1.1	-0.3	1.0	0.7	1.5	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.0	-0.5	-0.8	-0.7	-0.5	-0.3	1.3	-0.9	-0.3	-0.7
Medication: Aspirin	0.1	0.1	0.4	-0.0	-0.1	0.6	0.1	0.1	-0.3	-0.6	0.0	-0.2	-0.1
Supplements: Vitamin C	0.7	0.8	2.4	0.1	1.3	1.0	0.9	1.6	-0.2	-1.4	0.1	-0.1	-0.5
Knee pain experienced in last month	0.2	0.4	1.4	0.8	0.6	0.5	0.7	0.4	0.4	-1.2	0.2	0.1	0.6
Hypertension (Self-reported)	1.2	3.4	8.6	-0.3	2.0	2.3	1.7	1.5	1.1	-2.9	2.4	0.9	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	7.1	2.1	-1.5	-0.7	-1.9	-1.7	-2.0	-1.6	-1.5	-2.7	-2.2
Illnesses of father: Heart disease	0.3	0.4	1.4	-1.2	-0.4	-0.6	-0.8	-0.7	0.3	-0.2	-0.1	-0.8	0.2
Illnesses of siblings: Diabetes	0.6	0.8	2.8	-1.4	0.6	0.3	0.3	0.5	1.7	0.1	1.0	0.5	1.1
Smoking status: Previous	0.7	1.0	1.8	1.0	1.1	0.8	1.1	1.0	0.7	0.3	1.4	0.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.8	-0.4	-1.2	-0.6	-0.6	-1.0	-0.7	2.0	-0.5	0.1	-0.3
Whole body fat-free mass	0.4	2.0	4.9	-0.4	-1.9	-2.2	-1.7	-1.7	-1.6	0.4	-0.7	-1.6	-0.4
Leg fat-free mass (right)	0.6	3.2	6.9	-0.4	-2.6	-2.6	-2.1	-2.4	-1.8	0.6	-1.0	-1.8	-0.6
Arm fat percentage (left)	0.6	2.4	8.5	1.1	1.1	1.2	1.4	0.7	1.3	-2.9	1.9	0.4	1.9
Average weekly red wine intake	1.1	1.6	3.5	-0.9	1.1	0.7	1.0	1.1	1.9	-1.2	1.8	0.9	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	4.9	-2.2	0.5	-0.9	-0.5	0.0	0.9	0.2	0.5	-0.1	0.5
Mood swings	0.3	0.5	1.4	-0.4	0.3	0.6	0.2	0.1	1.1	-1.2	0.9	0.2	0.9
Loneliness, isolation	0.4	0.6	2.4	-0.1	0.2	0.0	0.8	0.5	0.2	1.4	0.5	1.6	0.5
Long-standing illness, disability or infirmity	1.6	2.5	5.0	1.7	1.9	2.2	2.2	2.1	0.3	-0.5	1.0	1.6	0.6
Ever had bowel cancer screening	1.4	1.7	4.4	-0.6	1.1	0.8	1.3	0.6	1.1	0.4	1.9	1.8	2.1
Diabetes diagnosed by doctor	0.9	1.4	3.5	1.0	0.9	1.9	1.3	1.1	1.6	-0.6	0.9	1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.5	1.6	-0.9	-0.6	-0.8	-0.9	-1.9	1.4	-1.4	-0.5	-1.4
Friendships satisfaction	5.3	6.6	10.6	-0.1	-2.8	-3.3	-3.1	-2.3	-2.7	1.3	-3.0	-2.5	-2.8
Qualifications: nursing, teaching	2.0	3.1	5.3	0.3	-1.8	-1.6	-2.2	-2.2	-1.7	-1.1	-1.8	-2.3	-1.7
Commuting to job workplace: Walk	3.2	3.4	9.1	0.3	-1.7	-1.5	-2.6	-1.8	-1.4	-0.9	-1.4	-3.0	-2.2
Eye problems/disorders: Cataract	1.5	1.7	3.3	-0.8	-1.6	-1.0	-1.4	-1.2	-1.2	1.0	-1.8	-1.2	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	-0.4	-1.0	-0.9	-1.0	-0.9	-0.3	-0.7	-0.7	-1.1	-0.9
Medication for cholesterol	1.9	2.8	5.3	-0.3	-2.3	-1.9	-2.1	-2.1	-1.3	0.4	-1.8	-1.9	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.1	1.0	0.5	0.5	0.7	0.1	-1.1	1.1	0.1	0.6
Back pain experienced in last month	0.2	0.3	1.1	0.0	0.2	-0.1	-0.3	0.4	-0.3	-1.1	-0.5	-0.9	-0.8
Mineral and other dietary supplements	3.9	5.2	11.8	-0.9	-2.7	-3.4	-2.6	-2.9	-1.7	2.8	-1.6	-1.2	-1.1
Breast cancer (self-reported)	3.2	3.9	6.3	-1.0	1.9	1.6	2.2	1.8	2.5	-0.9	2.3	2.2	2.4
Asthma (self-reported)	0.3	0.7	2.0	1.4	0.3	0.6	-0.3	0.2	-1.3	-0.3	-0.8	-0.9	-1.0
Osteoporosis (self-reported)	0.6	0.7	2.5	-0.2	0.6	0.9	1.0	0.8	0.4	1.2	0.5	1.6	0.6
Osteoarthritis (self-reported)	2.4	3.2	5.5	1.7	2.2	2.4	2.3	2.1	1.2	-0.2	1.6	1.7	1.3
Medication: Aspirin	0.1	0.1	0.5	0.0	-0.1	0.7	0.2	0.2	-0.2	-0.4	0.0	-0.0	-0.1
Medication: Gliclazide	0.3	0.4	1.0	-1.0	0.5	0.0	0.1	0.3	0.8	-0.9	0.8	-0.2	0.4
Illnesses of father: None of the above (group 1)	0.4	0.6	2.4	1.2	0.5	0.5	0.6	0.6	-0.2	1.5	0.1	0.7	-0.0
Smoking status: Current	3.1	4.9	11.5	0.4	2.4	2.8	2.4	2.0	2.5	-3.4	2.2	1.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.8	-1.3	0.5	-0.3	-0.1	0.2	1.2	-1.7	1.0	-0.5	0.5
Whole body water mass	0.4	2.2	5.0	-0.3	-1.9	-2.2	-1.8	-1.8	-1.7	0.4	-0.8	-1.6	-0.5
Leg predicted mass (right)	0.6	3.4	7.2	-0.4	-2.7	-2.7	-2.1	-2.5	-1.9	0.6	-1.1	-1.8	-0.7
Arm fat mass (left)	0.2	1.0	5.8	0.6	0.1	-0.0	0.3	-0.3	0.5	-2.4	1.2	-0.4	1.4
Number of self-reported non-cancer illnesses	2.3	3.9	8.9	1.4	2.4	3.0	1.9	2.2	1.2	-2.8	1.9	0.6	1.1
Average weekly champagne plus white wine intake	1.4	2.0	6.7	-0.6	-1.6	-2.6	-1.4	-1.8	-1.2	1.0	-1.2	-0.7	-0.7
Miserableness	0.2	0.3	1.3	-1.1	0.5	-0.3	-0.0	0.1	0.6	-0.7	0.8	0.1	0.6
Guilty feelings	0.5	0.8	2.8	-0.6	0.7	0.4	1.0	1.2	-0.6	1.1	0.4	1.7	0.4
Wears glasses or contact lenses	0.5	0.6	1.6	1.1	-0.0	0.5	-0.8	0.2	-0.2	-0.9	-0.5	-1.3	-1.1
Ever taken oral contraceptive pill	0.7	0.8	1.8	-0.6	0.5	0.7	0.9	0.3	0.8	1.0	1.1	1.3	1.3
Hearing aid user	3.5	4.0	6.5	1.1	-1.9	-1.6	-2.2	-1.5	-2.3	1.9	-2.4	-1.9	-2.5
Mother’s age at death	0.2	0.3	1.5	-1.2	0.2	-0.2	-0.3	0.4	0.5	-0.4	-0.6	-0.4	-0.6
Financial situation satisfaction	2.5	3.1	5.7	1.0	2.4	2.4	2.1	2.3	1.1	-0.9	1.5	1.6	1.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.9	0.7	1.4	0.8	1.9	1.8	-0.5	2.6	0.4	2.2	0.5
Commuting to job workplace: Public transport	0.4	0.5	2.3	-0.4	0.5	0.8	0.1	0.3	0.9	1.5	0.6	0.5	0.6
Eye problems/disorders: Glaucoma	2.6	3.1	6.1	0.5	2.5	2.3	2.0	2.4	1.3	-0.4	1.6	1.9	1.3
Medication: Blood pressure	0.4	0.7	1.6	-0.1	1.3	1.0	1.1	1.2	-0.0	-0.4	0.7	0.8	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.2	-0.1	-0.5	-0.3	-0.3	-0.5	-0.4	0.1	-0.5	0.1
Supplements: Fish oil (including cod liver oil)	3.0	3.9	8.6	-0.0	2.5	2.8	2.0	2.8	1.3	-2.9	1.2	0.6	0.4
High cholesterol (Self-reported)	4.1	7.2	12.8	-0.4	3.5	3.3	3.4	3.6	2.0	0.0	2.5	3.1	2.3
Medication: Bendroflumethiazide	1.1	1.7	7.0	-1.8	1.3	1.0	0.8	0.9	1.1	-2.7	0.9	0.0	0.3
Medication: Paracetamol	0.8	1.3	5.7	1.3	0.5	1.6	0.2	0.5	0.1	-2.4	-0.4	-0.7	-1.1
Medication: Lisinopril	0.3	0.4	1.9	-0.1	0.1	0.3	0.3	0.2	0.4	1.4	0.4	1.0	0.6
Medication: Atorvastatin	0.5	0.6	1.5	-0.2	0.9	1.2	0.6	0.8	0.9	-0.3	1.1	0.5	0.7
Illnesses of father: High blood pressure	0.6	0.8	2.8	-1.1	0.6	0.3	0.5	0.4	1.0	-1.7	1.0	0.3	0.8
Alcohol drinker status: Never	1.0	1.2	3.0	1.7	-0.4	1.0	0.6	0.3	-1.2	1.7	-1.4	0.5	-0.7
Ever smoked	3.2	5.7	9.8	0.3	2.8	2.4	2.3	2.1	3.1	-2.1	3.1	1.4	2.7
Basal metabolic rate	0.3	1.5	3.8	-0.3	-1.6	-2.0	-1.4	-1.6	-1.4	0.1	-0.5	-1.4	-0.2
Leg fat percentage (left)	1.4	5.0	11.1	0.7	2.3	1.9	2.3	1.6	2.4	-3.3	2.6	1.3	2.8
Arm fat-free mass (left)	0.3	1.7	4.9	-0.4	-1.5	-2.2	-1.6	-1.6	-1.4	0.1	-0.4	-1.5	-0.1
Number of operations (self-reported)	5.2	7.8	11.9	-0.3	3.5	2.9	3.1	3.0	3.1	-2.3	3.4	2.2	2.7
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.1	0.2	0.5	0.4	0.6	0.4	0.6	0.4	0.6	0.7
Irritability	0.4	0.6	1.8	-0.7	-1.0	-1.3	-0.8	-1.1	-0.5	0.4	-0.4	-0.4	0.2
Risk taking	0.1	0.1	0.4	0.1	-0.4	0.1	-0.1	-0.0	-0.6	-0.3	-0.6	-0.2	-0.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.6	-1.9	0.6	-0.0	-0.0	-0.0	1.9	-0.5	1.5	0.3	1.4
Fractured/broken bones in last 5 years	1.0	1.3	6.3	2.5	0.3	1.0	0.8	0.9	-1.5	0.2	-0.8	0.1	-1.2
Age started oral contraceptive pill	1.9	2.4	3.7	0.2	-1.6	-1.5	-1.5	-1.2	-1.9	1.9	-1.9	-1.1	-1.7
Diastolic blood pressure, automated reading	1.1	3.3	7.6	0.6	2.2	2.4	2.0	1.7	1.1	-2.8	2.0	1.0	1.3
Ever depressed for a whole week	0.6	0.7	2.3	0.3	-0.4	-0.7	-0.7	-0.3	-1.5	-0.3	-1.2	-0.7	-1.3
Unable to work because of sickness or disability	0.6	0.8	2.0	0.9	1.0	1.4	1.0	1.2	0.8	-0.8	0.4	0.6	0.1
Commuting to job workplace: Cycle	0.6	0.7	2.4	1.2	-0.2	0.5	-0.4	0.2	-0.7	0.5	-1.4	-0.3	-1.6
Myopia	3.6	5.3	11.6	-1.0	1.9	1.7	2.2	1.7	3.4	0.1	3.0	2.4	3.4
Vascular/heart problems diagnosed by doctor	1.3	3.5	8.2	0.9	-2.0	-2.0	-1.8	-1.5	-1.1	2.9	-2.6	-1.1	-1.9
Cholesterol lowering medication	1.8	2.7	6.2	0.6	2.0	2.2	2.4	2.5	0.2	0.5	0.8	2.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.4	0.8	0.7	0.1	0.8	0.8	-1.4	-0.0	-0.6	-0.5
Pain experienced in last month	0.5	0.9	3.3	-1.2	-1.0	-1.0	-0.6	-0.5	-0.3	1.8	-0.9	0.1	-0.7
Supplements: Calcium	2.0	2.2	4.8	0.1	2.1	1.6	1.3	1.6	0.9	-2.2	2.0	0.5	1.2
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	-0.8	-0.2	-0.1	-0.1	0.3	-0.9	0.9	-0.9	0.0	-1.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.4	-0.2	0.3	0.5	0.1	0.2	0.2	0.2	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.2	0.4	0.5	0.4	0.5	-0.3	-1.0	-0.2	0.0	-0.3
Heart disease (siblings)	0.2	0.2	0.4	0.6	0.0	0.3	0.6	0.1	-0.4	-0.0	0.6	0.5	0.5
Alcohol drinker status: Previous	0.4	0.5	1.3	1.1	-0.7	-0.7	-0.7	-0.8	-0.8	0.1	0.1	-0.9	0.2
Pack years of smoking	2.3	3.4	6.7	0.8	2.1	2.5	2.6	2.4	1.2	-0.6	1.4	2.3	1.5
Impedance of whole body	0.4	2.1	5.8	-0.4	1.1	1.6	1.7	1.2	1.1	2.0	0.9	2.4	1.0
Leg fat mass (left)	0.4	1.7	7.0	0.4	0.8	0.5	1.0	0.4	1.2	-2.6	1.6	0.2	1.9
Arm predicted mass (left)	0.2	1.3	3.4	0.0	-1.2	-1.8	-1.3	-1.3	-1.4	-0.1	-0.4	-1.4	-0.2