[Hub]/) : Traits : Lung FVC : ← →

chr17:6,397,773-8,535,817

Best TWAS P=1.63e-14 · Best GWAS P=1.3e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	-7.5	-7.5	8.3e-14	0.96	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	-5.5	-6.9	5.0e-12	0.84	0.02	0.98	FALSE
3	GTEx	Artery Aorta	CHRNB1	0.23	0.10	enet	7	0.13	1.3e-07	2.5	-5.2	1.7e-07	0.70	0.05	0.95	FALSE
4	GTEx	Artery Coronary	CHRNB1	0.26	0.08	enet	24	0.11	1.3e-04	-7.5	-6.0	2.4e-09	0.76	0.02	0.92	FALSE
5	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	-5.5	-6.1	1.3e-09	0.75	0.02	0.98	FALSE
6	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	-5.5	-7.0	2.8e-12	0.87	0.02	0.98	FALSE
7	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	-7.7	-7.7	1.6e-14	1.00	0.01	0.99	TRUE
8	GTEx	Esophagus Muscularis	CHRNB1	0.35	0.19	lasso	7	0.28	1.9e-17	2.5	-5.1	2.9e-07	0.66	0.55	0.45	FALSE
9	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	-7.5	-7.5	9.2e-14	0.96	0.01	0.97	FALSE
10	GTEx	Heart Left Ventricle	CHRNB1	0.16	0.03	lasso	4	0.05	9.6e-04	3.7	-5.7	9.4e-09	0.49	0.03	0.78	TRUE
11	GTEx	Lung	CNTROB	0.15	0.06	enet	28	0.07	9.5e-06	3.8	-6.8	1.2e-11	0.21	0.64	0.03	TRUE
12	GTEx	Lung	CHRNB1	0.22	0.05	enet	17	0.14	7.5e-11	1.6	-6.4	1.9e-10	0.73	0.01	0.99	FALSE
13	GTEx	Muscle Skeletal	DLG4	0.12	0.05	lasso	4	0.05	2.3e-05	5.5	-5.7	1.5e-08	0.06	0.92	0.00	TRUE
14	GTEx	Pancreas	CNTROB	0.14	0.06	lasso	8	0.03	1.5e-02	3.7	-5.6	2.0e-08	0.35	0.14	0.64	FALSE
15	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	-7.5	-7.3	2.7e-13	0.67	0.04	0.63	FALSE
16	GTEx	Prostate	AC113189.5	0.43	0.02	lasso	5	0.01	2.0e-01	-6.5	6.5	7.0e-11	-0.49	0.05	0.25	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	-5.5	-7.1	1.7e-12	0.87	0.01	0.99	FALSE
18	GTEx	Skin Sun Exposed Lower leg	DVL2	0.10	0.03	lasso	2	0.02	1.5e-02	5.5	5.4	7.0e-08	-0.04	0.81	0.04	FALSE
19	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	-7.7	-7.6	3.3e-14	0.94	0.01	0.99	TRUE
20	GTEx	Skin Sun Exposed Lower leg	CTDNEP1	0.10	0.06	lasso	6	0.06	9.5e-06	4.5	-5.6	2.3e-08	0.05	0.80	0.01	FALSE
21	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	-5.5	-5.7	1.2e-08	0.70	0.04	0.95	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	FGF11	0.08	0.04	blup	454	0.04	1.2e-05	3.7	-6.4	1.3e-10	0.57	0.73	0.26	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	NLGN2	0.25	0.24	lasso	2	0.24	3.0e-30	-5.6	5.5	4.5e-08	-0.56	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	-5.5	-6.6	4.4e-11	0.86	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	CLDN7	0.07	0.06	lasso	4	0.05	3.9e-07	5.5	5.6	1.7e-08	-0.08	0.96	0.01	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	AC113189.5	0.11	0.06	lasso	6	0.06	2.1e-08	-5.0	5.2	2.0e-07	-0.34	1.00	0.00	FALSE
27	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	-5.6	-7.1	1.3e-12	0.87	0.04	0.96	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	-5.6	-6.0	2.3e-09	0.75	0.71	0.29	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	-5.5	-5.2	2.3e-07	0.57	0.03	0.41	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	-7.0	-7.3	3.0e-13	0.85	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMAC1L3	0.04	0.02	blup	54	0.02	3.9e-03	-6.2	6.7	2.6e-11	-0.84	0.03	0.89	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	-5.4	-5.8	7.9e-09	0.61	0.41	0.27	TRUE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SHBG	0.05	0.02	lasso	3	0.02	8.1e-04	-6.5	6.4	1.9e-10	-0.46	0.00	0.98	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	-5.6	-5.7	9.3e-09	0.67	0.13	0.71	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	1.5	5.2	2.2e-07	-0.50	0.01	0.16	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	-5.5	-6.8	1.5e-11	0.69	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Rectum Adenocarcinoma	DULLARD	0.15	0.10	blup	41	0.11	1.4e-03	4.5	-5.2	1.9e-07	0.07	0.06	0.32	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHRNB1	0.07	0.03	enet	8	0.03	6.9e-03	-5.4	-5.6	2.3e-08	0.58	0.02	0.23	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf81	0.13	0.09	blup	43	0.08	1.1e-03	4.6	5.4	5.8e-08	-0.07	0.11	0.54	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	3.7	-6.5	5.9e-11	0.77	0.02	0.95	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	FXR2	0.04	0.03	lasso	1	0.02	1.8e-03	-5.7	-5.7	1.1e-08	0.34	0.08	0.35	FALSE
42	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C17orf81	0.19	0.06	blup	42	0.10	1.2e-03	4.6	5.1	3.0e-07	-0.08	0.10	0.40	FALSE