TWAS hub - FGF11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0664	0.0215	0.00016	0.005	0.021	0.007	0.024	0.006	5.3e-02	3.0e-04	2.5e-02	1.5e-04	4.2e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.0770	0.0256	0.00017	0.039	0.037	0.036	0.032	0.034	8.3e-06	1.2e-05	1.6e-05	4.4e-05	2.8e-05
3	YFS	Blood	0.0176	0.0080	0.00780	0.008	0.004	0.007	0.005	0.007	1.0e-03	1.1e-02	1.4e-03	6.4e-03	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Amlodipine	7.1	9.9	16.1	4.0	-2.9	-2.2
Medication: Bendroflumethiazide	7.0	10.7	20.9	2.0	-4.6	-2.7
Medication: Blood pressure	6.9	13.1	30.9	2.3	-5.6	-1.7
Waist Hip Ratio (WHR)	6.0	26.8	60.2	-3.5	7.8	2.8
High blood pressure (siblings)	5.8	8.3	15.8	0.1	-3.0	-4.0
Height	5.6	108.6	216.1	-14.7	9.8	3.7
Major Depression (MDD)	5.5	6.7	10.1	3.1	-3.2	0.0
Deep venous thrombosis (DVT) (self-reported)	5.3	6.9	9.7	2.4	-3.1	-2.2
Standing height	5.1	50.4	108.2	-10.4	6.3	1.6
Alcohol usually taken with meals	5.0	8.1	14.5	-2.8	3.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	5.0	8.1	11.7	2.8	-3.4	-2.1
Blood clot in the leg (DVT)	5.0	6.4	9.7	2.4	-3.1	-2.0
Hypertension (Self-reported)	4.9	13.5	27.9	2.1	-5.3	-2.9
Sitting height	4.8	33.8	69.6	-8.3	5.5	1.2
Lung FVC	4.7	24.2	41.2	5.0	-6.4	-2.5
High blood pressure	4.7	13.1	25.8	1.7	-5.1	-3.2
Neuroticism	4.6	11.1	18.1	2.0	-4.2	-3.4
Respiratory disease	4.2	9.4	19.0	-1.9	4.4	2.4
Stomach or abdominal pain in last month	4.2	5.2	10.2	3.2	-2.2	0.6
Mean time to correctly identify matches	4.0	7.7	14.7	-1.4	3.8	2.5
Wears glasses or contact lenses	3.9	4.5	7.4	-2.0	2.7	1.5
Frequency of depressed mood in last 2 weeks	3.8	5.3	6.7	2.0	-2.3	-2.6
Worry (Nagel 2018)	3.5	7.4	13.5	1.6	-3.7	-2.4
Systolic Blood Pressure	3.4	17.0	32.4	2.1	-5.7	-3.8
Vascular/heart problems diagnosed by doctor	3.4	9.4	20.5	-1.0	4.5	2.6
Neuroticism score	3.3	6.8	9.5	1.8	-3.1	-2.8
Trunk fat-free mass	3.2	18.4	27.8	-5.2	5.3	1.0
Trunk predicted mass	3.2	18.2	27.6	-5.1	5.2	1.0
Average weekly champagne plus white wine intake	3.2	4.4	6.9	-2.6	-0.5	-2.5
Miserableness	3.2	5.6	7.1	2.5	-2.7	-1.9
Number of operations (self-reported)	3.2	4.8	10.2	-0.6	-3.2	-2.0
Systolic blood pressure, automated reading	3.1	9.1	20.3	1.0	-4.5	-2.4
Arm fat percentage (left)	3.1	12.3	28.8	2.3	-5.4	-1.6
Illnesses of father: High blood pressure	3.1	3.9	8.9	1.5	-3.0	-0.7
Reaction Time	3.0	5.7	9.2	-0.1	3.0	2.8
Neuroticism (2016)	3.0	4.3	11.0	0.5	-3.3	-1.2
Ever used hormone-replacement therapy (HRT)	3.0	3.9	11.4	-3.4	0.1	-0.4
Asthma	3.0	5.8	9.1	-0.3	2.9	3.0
Medication: Allopurinol	3.0	4.0	5.6	1.2	-2.4	-2.2
Mood swings	3.0	5.5	7.9	1.6	-2.5	-2.8
Mother’s age at death	3.0	3.8	6.4	-2.1	2.5	0.6
Depression (Nagel 2018)	2.9	4.4	7.4	2.7	-2.0	-1.4
Tense / ‘highly strung’	2.9	4.7	7.3	1.8	-2.7	-1.9
Asthma (self-reported)	2.9	5.8	9.4	-0.3	2.8	3.1
Body Mass Index (BMI) (2010)	2.8	3.8	9.4	3.1	-1.0	-1.0
High blood pressure (mother)	2.8	4.0	5.3	1.3	-2.3	-2.2
Cardiovascular Disease	2.7	9.0	17.8	1.7	-4.2	-2.5
Diabetes (father)	2.7	3.3	8.7	-0.4	2.9	1.1
Guilty feelings	2.7	4.1	10.1	0.4	-3.2	-1.5
Schizophrenia vs Biploar Disorder	2.6	3.5	5.1	-2.3	2.1	1.0
Arm fat percentage (right)	2.6	10.2	24.4	1.9	-4.9	-1.6
Gout (self-reported)	2.6	3.6	5.9	1.0	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	9.9	-3.1	2.4	0.2
Number of self-reported non-cancer illnesses	2.6	4.5	6.2	1.7	-2.5	-2.0
Basal cell carcinoma (self-reported)	2.5	3.0	7.0	1.4	-2.6	0.3
Neuroticism (Nagel 2018)	2.4	5.6	11.4	1.7	-3.4	-1.7
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.0	-2.0	1.9	0.4
Hand grip strength (right)	2.4	6.5	14.5	-1.9	3.8	1.3
Fed-up feelings	2.3	4.2	8.5	1.5	-2.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	4.9	2.2	-1.5	-1.5
Medication: Lansoprazole	2.3	2.7	3.4	1.7	-1.8	-1.4
Length of working week for main job	2.3	2.5	6.0	-2.5	1.1	-0.5
Medication: Blood pressure	2.3	4.1	4.4	1.9	-2.1	-2.0
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	4.5	-0.4	-1.9	-2.1
Average weekly red wine intake	2.3	3.4	4.5	-2.0	2.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	5.7	0.6	-2.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	7.5	2.7	-2.3	-1.3
Arm fat-free mass (left)	2.3	11.5	18.6	-3.9	4.3	0.8
Relative age of first facial hair	2.2	4.5	5.2	2.0	-2.0	-2.3
Qualifications: CSEs or equivalent	2.2	2.9	5.1	1.8	-2.2	-0.8
Prospective memory result	2.2	2.7	4.2	2.0	-2.0	-0.3
Hair/balding pattern: Pattern 4	2.2	5.4	11.6	-2.1	3.4	-0.5
Fractured/broken bones in last 5 years	2.2	2.9	6.8	-2.6	0.9	-1.0
Arm predicted mass (left)	2.2	11.4	18.5	-3.9	4.3	0.8
Depressed Affect (Nagel 2018)	2.1	4.4	6.4	2.0	-2.5	-1.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.0	2.2	-0.6	-1.5
Number of live births	2.1	3.0	7.9	2.8	-1.0	0.1
Exposure to tobacco smoke at home	2.1	2.4	4.3	2.1	1.1	1.3
Alcohol drinker status: Never	2.1	2.5	5.6	2.4	-1.1	-0.8
Smoking Status	2.0	4.9	12.8	1.3	-3.6	0.5
Body fat percentage	2.0	8.0	19.2	1.2	-4.4	-1.9
Arm fat-free mass (right)	2.0	10.3	17.6	-3.6	4.2	0.3
Arm predicted mass (right)	2.0	10.5	19.1	-3.5	4.4	0.6
Eye problems/disorders: Cataract	2.0	2.3	5.2	0.5	-2.3	1.2
Ever depressed for a whole week	2.0	2.5	6.2	0.8	-2.5	-0.8
Hand grip strength (left)	1.9	5.0	8.5	-2.9	2.5	0.5
Trunk fat percentage	1.9	7.7	19.6	0.4	-4.4	-1.8
Happiness	1.9	2.3	6.5	0.7	-2.5	-0.2
Qualifications: A levels/AS levels or equivalent	1.9	4.1	8.0	-2.0	2.8	0.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	4.4	0.2	-1.7	-2.1
Whole body fat-free mass	1.9	11.1	16.9	-4.1	4.0	0.7
Whole body water mass	1.9	10.6	16.1	-4.0	3.9	0.8
Medication: Lisinopril	1.9	2.5	6.4	0.7	-2.5	-0.7
Lupus	1.8	2.8	4.1	-2.0	-1.6	-1.4
Sensitivity / hurt feelings	1.8	3.1	5.0	1.5	-2.2	-1.4
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.2	-2.3	0.4	-0.9
Had menopause	1.8	2.3	4.1	-2.0	0.1	1.6
Impedance of arm (right)	1.8	8.2	20.4	-1.9	-4.5	-0.7
Time employed in main current job	1.8	2.1	4.8	-2.2	0.3	-1.2
Headache pain in last month	1.8	3.0	8.8	3.0	-0.3	0.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.2	-0.9	0.5	2.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	3.5	-0.0	-1.9	-1.6
Impedance of arm (left)	1.7	7.9	21.3	-1.4	-4.6	-0.5
Neck or shoulder pain in last month	1.7	2.4	4.5	1.5	-2.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.7	2.1	3.7	0.1	1.9	1.6
Heel T-Score	1.6	12.6	25.5	5.0	-2.1	2.8
Hearing difficulty/problems: Yes	1.6	2.4	5.6	-0.8	-1.0	-2.4
Chronic bronchitis/emphysema (father)	1.6	1.9	2.9	-1.7	1.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.4	2.3	-0.3	-1.4
Heart attack	1.6	2.0	3.6	0.1	1.9	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.1	-0.4	-1.5	-1.8
Birth weight of first child	1.6	2.9	4.6	-1.6	2.1	1.3
Alcohol intake frequency.	1.6	3.8	7.6	1.4	-1.4	-2.8
Chest pain or discomfort	1.6	2.3	6.6	-0.6	2.6	0.4
Loneliness, isolation	1.6	2.2	3.8	2.0	-1.5	-0.6
Qualifications: nursing, teaching	1.6	2.5	5.3	-2.3	1.4	-0.5
Medication for cholesterol	1.6	2.5	5.9	-0.7	2.4	1.1
Diastolic blood pressure, automated reading	1.6	5.1	10.3	-0.6	-3.2	-2.2
Heart disease (siblings)	1.6	1.9	3.6	-1.0	1.9	1.1
HDL Cholesterol	1.5	2.5	3.7	-0.5	-1.9	-1.9
Blood Eosinophil Count	1.5	11.5	31.8	5.6	-1.6	-0.4
BMI	1.5	8.8	11.6	2.9	-3.4	-2.5
Lung FEV1/FVC ratio	1.5	7.7	18.3	4.3	1.4	1.7
Current tobacco smoking	1.5	2.5	3.5	1.9	-1.8	0.9
Had other major operations	1.5	1.8	4.7	-0.2	-2.2	-0.8
Illnesses of siblings	1.5	2.1	5.7	0.4	0.7	2.4
Heart disease (mother)	1.5	1.8	2.6	-1.2	1.2	-1.6
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.7	0.0	-1.6	-2.8
Ever had hysterectomy (womb removed)	1.4	1.6	3.4	0.5	-1.8	-1.1
Medication: Co-codamol	1.4	1.6	3.6	-0.2	-1.9	-1.1
Medication: Ramipril	1.4	1.8	2.6	1.3	-1.6	-1.0
Pulse wave reflection index	1.4	1.7	2.3	1.2	-1.2	-1.5
Comparative height size at age 10	1.4	7.6	15.9	-4.0	2.4	1.1
Commuting to job workplace: Walk	1.4	1.5	3.3	-0.9	-0.7	-1.8
Smoking status: Current	1.4	2.2	3.7	1.5	-1.9	0.7
Medication: Atorvastatin	1.4	1.8	3.2	0.5	1.3	1.8
Leg fat percentage (left)	1.4	5.0	8.1	1.8	-2.8	-1.9
Irritability	1.4	2.4	3.9	2.0	-1.2	-1.3
Bipolar Disorder (2018)	1.3	2.1	5.7	2.4	-0.5	0.5
Average weekly fortified wine intake	1.3	1.5	2.2	-1.5	1.4	0.7
Relative age voice broke	1.3	2.0	3.1	0.3	-1.8	-1.7
Body mass index (BMI)	1.3	5.3	7.2	2.6	-2.7	-1.5
Illnesses of mother	1.3	1.5	4.3	-0.6	-0.1	2.1
Birth weight	1.3	2.8	5.5	1.5	2.3	0.8
Leg fat percentage (right)	1.3	4.5	7.6	1.8	-2.8	-1.7
Qualifications: College or University degree	1.3	4.0	6.3	-2.2	2.5	-0.8
Pulse rate, automated reading	1.3	4.3	7.6	-2.3	2.8	-0.1
Osteoarthritis (self-reported)	1.3	1.7	2.0	-1.4	-1.2	-1.3
Ever taken oral contraceptive pill	1.3	1.4	3.4	-0.0	1.9	0.9
Financial situation satisfaction	1.3	1.6	3.2	1.2	-1.8	-0.2
Basal metabolic rate	1.3	7.4	13.3	-3.6	3.0	0.3
Unable to work because of sickness or disability	1.3	1.7	2.4	1.3	1.5	1.0
Breast Cancer	1.2	2.9	8.5	-2.9	-0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	4.8	0.9	1.5	2.2
Supplements: Glucosamine	1.2	1.6	2.0	-1.4	1.4	-1.0
Pulse wave Arterial Stiffness index	1.2	1.4	3.0	-1.7	0.8	-0.9
Risk taking	1.2	1.8	4.9	0.1	-0.7	2.2
Alzheimer’s Disease (in father)	1.1	1.2	1.8	-1.3	0.9	1.0
Lung cancer (father)	1.1	1.3	3.5	-0.3	-0.5	-1.9
Illnesses of father: Heart disease	1.1	1.5	2.3	1.1	-1.1	-1.5
Alcohol intake versus 10 years previously	1.0	1.4	2.5	-0.7	1.2	1.6
Falls in the last year	1.0	1.4	2.8	1.0	-0.6	1.7
Hair/balding pattern: Pattern 3	1.0	1.6	2.6	0.4	1.4	1.6
Comparative body size at age 10	1.0	2.7	3.2	1.8	-1.3	-1.8
Suffer from ‘nerves’	1.0	1.6	2.8	1.7	-1.3	-0.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.1	-1.2	0.6	1.4
Rheumatoid Arthritis	0.9	1.2	1.6	0.8	-1.2	-1.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.5	-0.6	1.5	1.6
Father’s age at death	0.9	1.2	1.8	-1.1	0.8	1.3
Medication: Cholesterol lowering	0.9	1.4	3.5	0.6	1.9	0.7
Breastfed as a baby	0.9	1.1	3.3	-0.2	-1.8	-0.2
Worry too long after embarrassment	0.9	1.6	3.9	-2.0	-0.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	1.1	-0.3	1.4
Smoking status: Previous	0.9	1.3	3.8	-1.9	0.0	0.4
Long-standing illness, disability or infirmity	0.9	1.3	2.4	-0.1	-1.6	-1.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.6	-0.5	-0.6	-1.6
Ulcerative Colitis (UC)	0.8	1.4	2.4	1.6	-1.1	-0.9
Ovarian Cancer	0.8	1.0	1.9	-1.0	-1.4	0.2
Fasting Glucose	0.8	1.0	2.7	0.3	1.6	0.2
Primary Biliary Cirrhosis	0.8	1.2	2.5	-1.6	-0.3	1.0
Trunk fat mass	0.8	3.4	6.9	-1.0	-2.6	-1.5
Pain all over the body in last month	0.8	0.8	1.8	-0.5	-0.6	-1.4
Medication: Simvastatin	0.8	1.2	1.8	1.3	-0.2	-1.3
Worrier / anxious feelings	0.8	1.6	2.7	1.0	-1.6	-1.0
Noisy workplace	0.8	1.0	2.9	-0.3	-1.7	0.1
Loud music exposure frequency	0.8	0.8	2.2	0.5	0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.5	0.1	0.6	1.6
Eye problems/disorders: None of the above	0.8	0.9	2.5	0.4	1.6	-0.1
Medication: Omeprazole	0.8	0.9	2.2	-1.5	0.7	-0.4
Had major operations	0.8	1.0	2.2	-0.8	-0.1	-1.5
Family relationship satisfaction	0.8	1.0	2.5	-0.7	-1.6	-0.4
Knee pain experienced in last month	0.8	1.3	3.6	-0.3	-1.9	-0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.3	0.8	-0.9	-1.2
Arm fat mass (left)	0.8	3.2	8.0	0.5	-2.8	-1.2
Age started oral contraceptive pill	0.8	1.0	1.7	-1.1	-0.4	-1.3
Cholesterol lowering medication	0.8	1.1	1.8	0.4	-1.4	-1.2
Supplements: Calcium	0.8	0.9	1.8	1.3	0.7	0.5
Age at First Birth	0.7	1.0	2.1	0.6	1.4	0.7
HbA1C	0.7	0.8	1.4	0.1	1.2	1.0
Chronotype (morning person)	0.7	1.7	2.6	1.6	-1.1	-1.1
Medication for hormone replacement therapy	0.7	0.8	1.8	-1.3	0.6	-0.4
Multivitamins +/- minerals	0.7	0.9	2.5	0.1	-0.5	-1.6
Medication: Atenolol	0.7	0.9	1.3	0.9	-1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.6	1.9	0.6	0.8
Allergy	0.7	1.6	2.6	0.3	-1.4	-1.6
Fluid intelligence score	0.7	1.4	3.8	0.6	0.1	-1.9
Pulse rate	0.7	1.1	1.7	-1.3	1.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.8	0.2	-1.3	-1.2
Medication: Paracetamol	0.7	1.1	3.1	1.8	0.1	-0.4
Glaucoma (self-reported)	0.7	0.8	1.3	-1.0	1.1	-0.4
Age at first live birth	0.7	1.2	3.2	-0.5	0.3	-1.8
Leg fat-free mass (right)	0.7	3.5	7.3	-2.7	1.8	0.2
Ever had bowel cancer screening	0.7	0.9	1.6	-1.3	0.9	0.4
Leg predicted mass (right)	0.7	3.6	7.3	-2.7	1.9	0.2
Impedance of whole body	0.7	3.4	6.9	-1.7	-2.6	-0.7
Prostate Cancer	0.6	0.8	1.6	-0.9	0.1	-1.3
Schizophrenia (2014)	0.6	1.2	1.8	-1.2	1.3	0.7
Ulcerative Colitis	0.6	0.9	2.0	1.4	-0.7	-0.6
Blood Red Count	0.6	5.6	9.4	3.1	-2.0	-1.8
Hypothyroidism (self reported)	0.6	1.4	1.8	-0.9	1.3	1.2
Number of treatments/medications taken	0.6	1.1	1.4	0.8	-1.2	-1.0
Medication: Metformin	0.6	0.9	1.9	-0.6	1.4	0.5
Diabetes (mother)	0.6	0.8	1.5	-0.8	1.2	0.2
Leg fat-free mass (left)	0.6	3.2	6.6	-2.6	1.7	0.3
Leg predicted mass (left)	0.6	3.0	6.2	-2.5	1.6	0.2
Number of incorrect matches in round	0.6	0.9	1.6	1.3	-0.9	0.7
Past tobacco smoking	0.6	1.0	1.6	1.2	0.6	-1.1
Hip circumference	0.6	2.4	4.6	-0.4	-2.1	-1.5
Arm fat mass (right)	0.6	2.6	6.4	0.2	-2.5	-1.2
Forced vital capacity (FVC), Best measure	0.6	2.0	4.5	-2.1	-0.8	-1.0
Number of children fathered	0.6	0.6	1.0	-0.9	0.4	-1.0
Pulse wave peak to peak time	0.6	0.7	1.0	1.0	-0.4	0.9
Health satisfaction	0.6	0.8	1.0	-0.7	-1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.0	1.0	-1.0	-0.1
Whole body fat mass	0.6	2.5	5.8	-0.4	-2.4	-1.3
Leg pain on walking	0.6	0.7	1.4	-1.2	0.9	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.2	0.9	1.1	0.6
Commuting to job workplace: Public transport	0.6	0.7	1.8	-0.4	1.4	-0.4
High cholesterol (Self-reported)	0.6	1.0	2.2	1.5	-0.2	-0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.7	-0.4	-1.2
Myopia	0.6	0.8	1.2	-1.0	-0.6	-1.1
Mean Putamen Volume	0.5	0.6	1.1	-0.2	1.0	0.8
Severe depression (siblings)	0.5	0.5	1.0	1.0	0.0	0.7
Pack years adult smoking proportion	0.5	0.8	2.0	1.4	-0.5	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	0.5	-0.3	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.8	-0.4	1.3	-0.1
Depression (self-reported)	0.5	0.6	1.3	1.1	-0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	0.1	1.0	-0.8
Number of full sisters	0.5	0.6	0.9	-0.5	0.9	0.9
Medication: Aspirin	0.5	0.6	1.2	0.6	-0.7	-1.1
Back pain experienced in last month	0.5	0.7	1.5	-1.2	-0.2	0.8
Hearing aid user	0.5	0.6	0.9	1.0	0.4	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	-1.2	0.6	0.1
Pain experienced in last month	0.5	0.9	2.1	0.7	1.5	0.3
Pack years of smoking	0.5	0.7	1.4	1.2	-0.5	0.6
Leg fat mass (left)	0.5	1.9	3.1	0.3	-1.8	-1.6
LDL Cholesterol	0.4	0.7	1.3	0.3	1.1	0.8
Allergy or Eczema	0.4	1.1	2.5	-0.9	1.6	-0.1
Vitamin and mineral supplements	0.4	0.6	1.3	0.1	1.1	0.7
Maternal smoking around birth	0.4	0.6	1.5	0.1	-0.7	1.2
Taking other prescription medications	0.4	0.6	1.1	1.0	-0.9	0.0
Impedance of leg (left)	0.4	1.9	4.6	-2.1	-0.3	-1.0
Forced vital capacity (FVC)	0.4	1.7	4.5	-2.1	-0.5	-0.6
Mouth/teeth dental problems	0.4	0.7	1.4	-0.1	1.2	0.8
Weight	0.4	1.9	5.1	-2.2	0.2	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.9	-0.4	0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-0.0	0.7	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.0	-0.7	0.8	1.0
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	-0.7	0.5	1.0
Migraine (self-reported)	0.4	0.5	1.5	1.2	0.0	-0.1
Leg fat mass (right)	0.4	1.5	2.5	0.3	-1.6	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.0	1.0	-0.6	-0.5
Ever smoked	0.4	0.8	1.6	-1.3	-0.2	0.8
Average weekly beer plus cider intake	0.4	0.6	1.6	-0.3	0.1	1.3
Alcohol drinker status: Previous	0.4	0.5	1.0	-0.1	-1.0	-0.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	-0.7	-0.8	-1.2
Schizophrenia (2018)	0.3	0.7	1.6	-1.3	0.6	-0.3
Crohns Disease (2017)	0.3	0.6	0.9	0.3	0.9	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	1.0	0.3	-0.2
Impedance of leg (right)	0.3	1.5	4.1	-2.0	-0.4	-0.6
Diabetes (self-reported)	0.3	0.4	1.3	0.0	-0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	0.2	0.8	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.8	0.4	-0.5
Diabetes diagnosed by doctor	0.3	0.4	0.9	-0.0	0.7	0.9
Friendships satisfaction	0.3	0.4	0.9	-0.4	-1.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	0.6	-1.0	-0.2
Medication: Aspirin	0.3	0.4	0.6	0.8	-0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	-0.2	-1.1	-0.1
Medication: Paracetamol	0.3	0.5	0.7	0.7	0.9	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.3	-0.5	-0.6	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	1.1	-0.4	-0.1
Crohns Disease (2012)	0.2	0.3	0.6	0.1	-0.7	0.8
Triglycerides	0.2	0.4	0.4	0.6	0.7	0.6
Blood White Count	0.2	1.6	3.6	1.1	1.9	0.2
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.3	-0.8	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	-0.1	1.0	0.7
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.0	1.0	-0.4
Nervous feelings	0.2	0.4	0.6	0.8	-0.7	0.1
Qualifications: None of the above	0.2	0.4	0.8	0.9	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.6	-0.8	-0.8	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.4	-0.7	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	-1.0	0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	-0.1	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.6	-0.7	-0.3
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.1	-0.1	0.8
Age at last live birth	0.2	0.3	0.6	-0.8	0.4	-0.2
Breast cancer (self-reported)	0.2	0.3	0.6	0.4	-0.2	-0.8
Medication: Gliclazide	0.2	0.3	0.4	0.6	-0.6	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.7	0.2	-0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.3	0.8	-0.3
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.1	-0.8	-0.3
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.4	-0.6	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	0.0	0.0	0.7
Blood Platelet Count	0.1	1.1	2.3	1.5	1.0	-0.2
Hair Pigment	0.1	2.6	6.6	-2.6	0.9	-0.7
Average weekly spirits intake	0.1	0.1	0.2	0.2	-0.5	0.2
Angina	0.1	0.1	0.3	-0.6	0.2	-0.3
Supplements: Zinc	0.1	0.1	0.2	0.3	-0.0	-0.4
Age when periods started (menarche)	0.1	0.2	0.4	-0.7	0.4	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.0	0.5	-0.2
Waist circumference	0.1	0.3	0.6	-0.6	0.8	-0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.4	-0.6	-0.6	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.1	-0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.4	0.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.1	-0.6	0.4
Number of full brothers	0.1	0.1	0.1	0.3	-0.4	-0.4
Emphysema/chronic bronchitis	0.1	0.2	0.2	-0.5	0.1	-0.5
Angina (self-reported)	0.1	0.2	0.5	-0.7	0.3	-0.0
Medication: Ibuprofen	0.1	0.1	0.2	-0.2	0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.2	-0.3	-0.2
Supplements: Vitamin C	0.1	0.2	0.3	0.2	-0.3	0.6
Mineral and other dietary supplements	0.1	0.1	0.3	0.2	0.2	0.5
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.5	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.6	1.3	-0.2	-0.6	-1.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.4	0.2	0.1
Financial difficulties in last 2 years	0.0	0.0	0.1	0.3	-0.1	-0.0
Peak expiratory flow (PEF)	0.0	0.1	0.1	-0.4	-0.3	0.0
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.1	0.1	0.3
Overall health rating	0.0	0.0	0.0	0.2	0.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.1	0.2	-0.3

Hub : Genes

FGF11

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Trait associations