[Hub]/) : Traits : Heel T-Score : ← →

chr16:88,074,533-90,172,696

Best TWAS P=1.02e-15 · Best GWAS P=7.15e-17 conditioned to 1.04e-21

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CTU2	0.10	0.07	lasso	5	0.08	4.0e-10	-5.0	5.6	2.4e-08	0.19	1.00	0.00	TRUE
2	GTEx	Adipose Subcutaneous	SPIRE2	0.12	0.04	lasso	4	0.07	2.7e-06	6.0	5.4	7.4e-08	-0.08	0.72	0.15	FALSE
3	GTEx	Brain Cerebellar Hemisphere	AC092143.1	0.20	0.01	enet	22	0.06	9.7e-03	5.7	7.1	9.3e-13	-0.01	0.04	0.59	FALSE
4	GTEx	Brain Cerebellum	AC092143.1	0.18	0.23	lasso	1	0.19	2.7e-06	5.7	5.8	9.0e-09	0.00	0.10	0.82	FALSE
5	GTEx	Brain Cortex	GAS8	0.28	0.16	lasso	6	0.14	1.3e-04	-4.1	-5.7	1.0e-08	-0.01	0.29	0.04	FALSE
6	GTEx	Brain Cortex	ACSF3	0.56	0.22	enet	42	0.21	2.4e-06	3.8	5.2	1.6e-07	-0.07	0.89	0.01	TRUE
7	GTEx	Breast Mammary Tissue	RPL13	0.09	0.05	enet	7	0.04	5.3e-03	3.2	-5.2	1.7e-07	0.01	0.18	0.55	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RPL13	0.10	0.00	lasso	1	0.03	4.6e-02	5.2	-5.2	2.2e-07	-0.04	0.04	0.14	FALSE
9	GTEx	Cells Transformed fibroblasts	CHMP1A	0.27	0.06	enet	23	0.11	7.0e-09	3.9	6.6	3.7e-11	-0.03	0.69	0.08	FALSE
10	GTEx	Colon Transverse	AC092143.1	0.10	0.05	lasso	4	0.03	1.3e-02	5.5	5.2	2.3e-07	-0.02	0.17	0.10	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	SPIRE2	0.46	0.13	lasso	7	0.26	5.9e-10	5.6	5.3	1.1e-07	-0.09	0.37	0.63	FALSE
12	GTEx	Esophagus Mucosa	TCF25	0.13	0.12	enet	9	0.09	1.7e-06	5.7	7.1	1.1e-12	-0.01	0.41	0.58	FALSE
13	GTEx	Esophagus Mucosa	SPIRE2	0.11	0.05	enet	8	0.07	1.3e-05	5.5	5.9	3.5e-09	-0.08	0.66	0.30	FALSE
14	GTEx	Esophagus Mucosa	AC092143.1	0.06	0.09	lasso	1	0.08	9.4e-06	5.7	5.8	9.0e-09	0.00	0.19	0.71	FALSE
15	GTEx	Muscle Skeletal	SPG7	0.24	0.22	lasso	5	0.23	8.9e-23	-5.1	-5.3	1.4e-07	-0.03	1.00	0.00	TRUE
16	GTEx	Pancreas	DBNDD1	0.26	0.16	enet	15	0.18	5.6e-08	-4.1	-5.9	3.5e-09	0.05	0.61	0.10	FALSE
17	GTEx	Pancreas	GAS8	0.19	0.08	lasso	4	0.06	1.9e-03	6.8	-8.0	1.0e-15	-0.02	0.02	0.95	TRUE
18	GTEx	Pancreas	FANCA	0.18	0.04	lasso	11	0.07	7.2e-04	3.9	5.1	2.7e-07	0.01	0.12	0.07	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	DBNDD1	0.40	0.19	lasso	5	0.19	8.2e-11	-4.1	-5.7	1.6e-08	0.05	0.99	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	GAS8	0.24	0.00	enet	23	0.08	2.6e-05	2.2	-6.2	4.6e-10	0.08	0.16	0.17	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	SPIRE2	0.15	0.08	enet	9	0.11	1.8e-06	5.6	6.1	1.2e-09	-0.05	0.86	0.13	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	URAHP	0.14	0.00	enet	13	0.08	3.1e-05	1.5	-6.5	8.5e-11	0.07	0.05	0.13	FALSE
23	GTEx	Skin Sun Exposed Lower leg	SPIRE2	0.28	0.29	enet	25	0.34	2.5e-29	5.6	5.5	3.2e-08	-0.06	0.91	0.09	FALSE
24	GTEx	Testis	SPIRE2	0.26	0.12	lasso	10	0.18	1.8e-08	3.5	5.2	2.6e-07	-0.08	0.70	0.27	FALSE
25	GTEx	Testis	AC092143.1	0.18	0.11	lasso	7	0.13	3.4e-06	5.5	6.3	2.1e-10	-0.03	0.11	0.87	FALSE
26	GTEx	Whole Blood	AC092143.1	0.13	0.16	enet	6	0.15	1.8e-13	5.7	5.8	8.2e-09	0.00	0.93	0.07	FALSE
27	METSIM	Adipose	CHMP1A	0.27	0.05	lasso	9	0.07	1.3e-10	3.9	6.0	1.8e-09	0.04	0.95	0.00	FALSE
28	METSIM	Adipose	MC1R	0.05	0.04	bslmm	307	0.04	1.1e-06	4.8	6.6	5.3e-11	0.00	0.02	0.98	FALSE
29	METSIM	Adipose	SPG7	0.17	0.07	enet	32	0.15	8.6e-22	-5.1	-6.6	4.6e-11	-0.04	0.82	0.18	FALSE
30	YFS	Blood	MC1R	0.24	0.23	blup	298	0.25	4.5e-80	5.7	5.5	5.0e-08	-0.01	0.87	0.13	FALSE
31	YFS	Blood	SPG7	0.08	0.11	lasso	6	0.11	6.9e-34	-5.0	-5.2	2.4e-07	-0.02	1.00	0.00	FALSE
32	YFS	Blood	TCF25	0.03	0.01	lasso	2	0.02	4.8e-08	4.8	5.4	5.9e-08	0.03	0.36	0.60	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPEP1	0.06	0.01	blup	45	0.03	1.7e-03	3.9	-5.6	2.5e-08	0.06	0.00	0.81	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF276	0.09	0.02	enet	12	0.05	2.3e-05	6.0	-6.6	4.5e-11	0.00	0.01	0.83	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPEP1	0.05	0.01	enet	7	0.02	5.2e-05	-5.5	-6.2	4.8e-10	0.01	0.02	0.86	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	FANCA	0.09	0.01	blup	78	0.05	7.8e-11	-3.4	7.4	1.6e-13	-0.05	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DPEP1	0.06	0.00	enet	5	0.02	2.5e-03	6.0	-7.5	7.2e-14	0.04	0.00	0.92	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SPIRE2	0.04	0.01	blup	72	0.01	3.4e-02	5.6	5.4	6.3e-08	0.03	0.02	0.20	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf55	0.07	0.05	enet	3	0.04	8.2e-06	-5.3	5.8	7.6e-09	-0.01	0.04	0.94	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FANCA	0.15	0.16	enet	13	0.16	4.2e-18	6.0	6.9	4.9e-12	-0.02	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHMP1A	0.18	0.01	enet	11	0.06	3.8e-04	3.9	6.0	1.8e-09	-0.04	0.01	0.82	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FANCA	0.22	0.20	lasso	8	0.26	7.9e-15	5.8	6.2	4.8e-10	-0.04	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPIRE2	0.19	0.07	enet	11	0.15	1.0e-08	5.5	6.4	1.3e-10	-0.08	0.18	0.71	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	MC1R	0.07	0.03	blup	47	0.04	1.8e-05	5.7	6.4	1.6e-10	-0.02	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF276	0.04	0.02	blup	46	0.01	1.3e-02	5.8	-6.5	7.8e-11	0.05	0.01	0.89	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf7	0.04	0.02	lasso	6	0.01	8.2e-03	5.2	5.9	2.8e-09	0.02	0.01	0.92	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPATA2L	0.03	0.01	lasso	2	0.01	1.9e-02	5.1	5.3	1.0e-07	-0.03	0.02	0.43	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TUBB3	0.17	0.00	blup	57	0.07	7.5e-04	1.6	-5.2	1.8e-07	0.04	0.02	0.29	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CENPBD1	0.18	0.02	lasso	2	0.03	1.6e-02	4.7	-5.3	1.3e-07	0.05	0.00	0.90	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPEP1	0.08	0.03	enet	3	0.04	3.2e-05	-5.5	-5.8	9.1e-09	-0.02	0.02	0.96	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	FANCA	0.08	0.03	blup	76	0.02	2.1e-03	-5.3	7.6	3.3e-14	-0.04	0.02	0.47	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	CHMP1A	0.11	0.09	blup	38	0.08	5.1e-08	-1.5	5.3	1.4e-07	-0.02	0.71	0.27	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	SPIRE2	0.12	0.06	enet	10	0.08	8.5e-08	4.6	5.8	5.7e-09	-0.06	0.63	0.20	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	TCF25	0.03	0.01	enet	5	0.01	2.0e-02	6.7	-6.0	1.9e-09	0.01	0.02	0.90	FALSE