[Hub]/) : Traits : Heel T-Score :

chr16:88,074,533-90,172,696

Best TWAS P=1.02e-15 · Best GWAS P=7.15e-17 conditioned to 1.04e-21

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CTU2 0.10 0.07 lasso 5 0.08 4.0e-10 -5.0 5.6 2.4e-08 0.19 1.00 0.00 TRUE
2 GTEx Adipose Subcutaneous SPIRE2 0.12 0.04 lasso 4 0.07 2.7e-06 6.0 5.4 7.4e-08 -0.08 0.72 0.15 FALSE
3 GTEx Brain Cerebellar Hemisphere AC092143.1 0.20 0.01 enet 22 0.06 9.7e-03 5.7 7.1 9.3e-13 -0.01 0.04 0.59 FALSE
4 GTEx Brain Cerebellum AC092143.1 0.18 0.23 lasso 1 0.19 2.7e-06 5.7 5.8 9.0e-09 0.00 0.10 0.82 FALSE
5 GTEx Brain Cortex GAS8 0.28 0.16 lasso 6 0.14 1.3e-04 -4.1 -5.7 1.0e-08 -0.01 0.29 0.04 FALSE
6 GTEx Brain Cortex ACSF3 0.56 0.22 enet 42 0.21 2.4e-06 3.8 5.2 1.6e-07 -0.07 0.89 0.01 TRUE
7 GTEx Breast Mammary Tissue RPL13 0.09 0.05 enet 7 0.04 5.3e-03 3.2 -5.2 1.7e-07 0.01 0.18 0.55 FALSE
8 GTEx Breast Mammary Tissue (Female) RPL13 0.10 0.00 lasso 1 0.03 4.6e-02 5.2 -5.2 2.2e-07 -0.04 0.04 0.14 FALSE
9 GTEx Cells Transformed fibroblasts CHMP1A 0.27 0.06 enet 23 0.11 7.0e-09 3.9 6.6 3.7e-11 -0.03 0.69 0.08 FALSE
10 GTEx Colon Transverse AC092143.1 0.10 0.05 lasso 4 0.03 1.3e-02 5.5 5.2 2.3e-07 -0.02 0.17 0.10 FALSE
11 GTEx Esophagus Gastroesophageal Junction SPIRE2 0.46 0.13 lasso 7 0.26 5.9e-10 5.6 5.3 1.1e-07 -0.09 0.37 0.63 FALSE
12 GTEx Esophagus Mucosa TCF25 0.13 0.12 enet 9 0.09 1.7e-06 5.7 7.1 1.1e-12 -0.01 0.41 0.58 FALSE
13 GTEx Esophagus Mucosa SPIRE2 0.11 0.05 enet 8 0.07 1.3e-05 5.5 5.9 3.5e-09 -0.08 0.66 0.30 FALSE
14 GTEx Esophagus Mucosa AC092143.1 0.06 0.09 lasso 1 0.08 9.4e-06 5.7 5.8 9.0e-09 0.00 0.19 0.71 FALSE
15 GTEx Muscle Skeletal SPG7 0.24 0.22 lasso 5 0.23 8.9e-23 -5.1 -5.3 1.4e-07 -0.03 1.00 0.00 TRUE
16 GTEx Pancreas DBNDD1 0.26 0.16 enet 15 0.18 5.6e-08 -4.1 -5.9 3.5e-09 0.05 0.61 0.10 FALSE
17 GTEx Pancreas GAS8 0.19 0.08 lasso 4 0.06 1.9e-03 6.8 -8.0 1.0e-15 -0.02 0.02 0.95 TRUE
18 GTEx Pancreas FANCA 0.18 0.04 lasso 11 0.07 7.2e-04 3.9 5.1 2.7e-07 0.01 0.12 0.07 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic DBNDD1 0.40 0.19 lasso 5 0.19 8.2e-11 -4.1 -5.7 1.6e-08 0.05 0.99 0.00 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic GAS8 0.24 0.00 enet 23 0.08 2.6e-05 2.2 -6.2 4.6e-10 0.08 0.16 0.17 FALSE
21 GTEx Skin Not Sun Exposed Suprapubic SPIRE2 0.15 0.08 enet 9 0.11 1.8e-06 5.6 6.1 1.2e-09 -0.05 0.86 0.13 FALSE
22 GTEx Skin Not Sun Exposed Suprapubic URAHP 0.14 0.00 enet 13 0.08 3.1e-05 1.5 -6.5 8.5e-11 0.07 0.05 0.13 FALSE
23 GTEx Skin Sun Exposed Lower leg SPIRE2 0.28 0.29 enet 25 0.34 2.5e-29 5.6 5.5 3.2e-08 -0.06 0.91 0.09 FALSE
24 GTEx Testis SPIRE2 0.26 0.12 lasso 10 0.18 1.8e-08 3.5 5.2 2.6e-07 -0.08 0.70 0.27 FALSE
25 GTEx Testis AC092143.1 0.18 0.11 lasso 7 0.13 3.4e-06 5.5 6.3 2.1e-10 -0.03 0.11 0.87 FALSE
26 GTEx Whole Blood AC092143.1 0.13 0.16 enet 6 0.15 1.8e-13 5.7 5.8 8.2e-09 0.00 0.93 0.07 FALSE
27 METSIM Adipose CHMP1A 0.27 0.05 lasso 9 0.07 1.3e-10 3.9 6.0 1.8e-09 0.04 0.95 0.00 FALSE
28 METSIM Adipose MC1R 0.05 0.04 bslmm 307 0.04 1.1e-06 4.8 6.6 5.3e-11 0.00 0.02 0.98 FALSE
29 METSIM Adipose SPG7 0.17 0.07 enet 32 0.15 8.6e-22 -5.1 -6.6 4.6e-11 -0.04 0.82 0.18 FALSE
30 YFS Blood MC1R 0.24 0.23 blup 298 0.25 4.5e-80 5.7 5.5 5.0e-08 -0.01 0.87 0.13 FALSE
31 YFS Blood SPG7 0.08 0.11 lasso 6 0.11 6.9e-34 -5.0 -5.2 2.4e-07 -0.02 1.00 0.00 FALSE
32 YFS Blood TCF25 0.03 0.01 lasso 2 0.02 4.8e-08 4.8 5.4 5.9e-08 0.03 0.36 0.60 FALSE
33 The Cancer Genome Atlas Bladder Urothelial Carcinoma DPEP1 0.06 0.01 blup 45 0.03 1.7e-03 3.9 -5.6 2.5e-08 0.06 0.00 0.81 FALSE
34 The Cancer Genome Atlas Bladder Urothelial Carcinoma ZNF276 0.09 0.02 enet 12 0.05 2.3e-05 6.0 -6.6 4.5e-11 0.00 0.01 0.83 FALSE
35 The Cancer Genome Atlas Breast Invasive Carcinoma DPEP1 0.05 0.01 enet 7 0.02 5.2e-05 -5.5 -6.2 4.8e-10 0.01 0.02 0.86 FALSE
36 The Cancer Genome Atlas Breast Invasive Carcinoma FANCA 0.09 0.01 blup 78 0.05 7.8e-11 -3.4 7.4 1.6e-13 -0.05 0.03 0.97 FALSE
37 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DPEP1 0.06 0.00 enet 5 0.02 2.5e-03 6.0 -7.5 7.2e-14 0.04 0.00 0.92 FALSE
38 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SPIRE2 0.04 0.01 blup 72 0.01 3.4e-02 5.6 5.4 6.3e-08 0.03 0.02 0.20 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C16orf55 0.07 0.05 enet 3 0.04 8.2e-06 -5.3 5.8 7.6e-09 -0.01 0.04 0.94 FALSE
40 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FANCA 0.15 0.16 enet 13 0.16 4.2e-18 6.0 6.9 4.9e-12 -0.02 0.01 0.99 FALSE
41 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CHMP1A 0.18 0.01 enet 11 0.06 3.8e-04 3.9 6.0 1.8e-09 -0.04 0.01 0.82 FALSE
42 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FANCA 0.22 0.20 lasso 8 0.26 7.9e-15 5.8 6.2 4.8e-10 -0.04 0.02 0.98 FALSE
43 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SPIRE2 0.19 0.07 enet 11 0.15 1.0e-08 5.5 6.4 1.3e-10 -0.08 0.18 0.71 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma MC1R 0.07 0.03 blup 47 0.04 1.8e-05 5.7 6.4 1.6e-10 -0.02 0.01 0.99 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF276 0.04 0.02 blup 46 0.01 1.3e-02 5.8 -6.5 7.8e-11 0.05 0.01 0.89 FALSE
46 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C16orf7 0.04 0.02 lasso 6 0.01 8.2e-03 5.2 5.9 2.8e-09 0.02 0.01 0.92 FALSE
47 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SPATA2L 0.03 0.01 lasso 2 0.01 1.9e-02 5.1 5.3 1.0e-07 -0.03 0.02 0.43 FALSE
48 The Cancer Genome Atlas Pancreatic Adenocarcinoma TUBB3 0.17 0.00 blup 57 0.07 7.5e-04 1.6 -5.2 1.8e-07 0.04 0.02 0.29 FALSE
49 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CENPBD1 0.18 0.02 lasso 2 0.03 1.6e-02 4.7 -5.3 1.3e-07 0.05 0.00 0.90 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma DPEP1 0.08 0.03 enet 3 0.04 3.2e-05 -5.5 -5.8 9.1e-09 -0.02 0.02 0.96 FALSE
51 The Cancer Genome Atlas Prostate Adenocarcinoma FANCA 0.08 0.03 blup 76 0.02 2.1e-03 -5.3 7.6 3.3e-14 -0.04 0.02 0.47 FALSE
52 The Cancer Genome Atlas Thyroid Carcinoma CHMP1A 0.11 0.09 blup 38 0.08 5.1e-08 -1.5 5.3 1.4e-07 -0.02 0.71 0.27 FALSE
53 The Cancer Genome Atlas Thyroid Carcinoma SPIRE2 0.12 0.06 enet 10 0.08 8.5e-08 4.6 5.8 5.7e-09 -0.06 0.63 0.20 FALSE
54 The Cancer Genome Atlas Thyroid Carcinoma TCF25 0.03 0.01 enet 5 0.01 2.0e-02 6.7 -6.0 1.9e-09 0.01 0.02 0.90 FALSE