[Hub]/) : Traits : Heel T-Score : ← →

chr17:3,587-3,000,009

Best TWAS P=2.47e-89 · Best GWAS P=2.84e-149 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RPA1	0.13	0.08	lasso	3	0.08	3.3e-10	4.88	5.2	2.0e-07	-0.09	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TIMM22	0.19	0.13	lasso	3	0.14	3.3e-17	-4.97	-5.3	9.0e-08	-0.01	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RP1-59D14.5	0.07	0.02	enet	22	0.05	3.0e-05	12.60	8.1	5.2e-16	-0.19	0.18	0.12	FALSE
4	GTEx	Adrenal Gland	RP11-676J12.4	0.23	0.02	enet	27	0.01	1.4e-01	-5.06	6.8	1.4e-11	0.00	0.05	0.12	TRUE
5	GTEx	Artery Aorta	RPA1	0.19	0.04	enet	32	0.11	9.3e-07	1.00	7.0	2.5e-12	-0.13	0.22	0.04	TRUE
6	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	4.82	-5.5	5.0e-08	0.37	0.98	0.01	FALSE
7	GTEx	Artery Tibial	SGSM2	0.12	0.02	enet	11	0.05	1.6e-04	-7.17	5.8	8.8e-09	-0.30	0.44	0.02	FALSE
8	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	4.82	-5.9	3.9e-09	0.39	1.00	0.00	FALSE
9	GTEx	Brain Caudate basal ganglia	SRR	0.26	0.03	lasso	3	0.02	8.6e-02	6.97	-7.6	2.1e-14	0.44	0.13	0.11	FALSE
10	GTEx	Brain Cerebellar Hemisphere	DPH1	0.35	0.31	lasso	2	0.31	9.8e-09	9.02	9.2	4.6e-20	-0.29	0.39	0.14	FALSE
11	GTEx	Brain Cerebellar Hemisphere	SRR	0.37	0.24	lasso	7	0.22	2.1e-06	4.61	-8.7	3.5e-18	0.47	0.27	0.58	FALSE
12	GTEx	Brain Cerebellum	SMG6	0.24	0.03	enet	16	0.05	1.3e-02	1.24	11.8	2.7e-32	-0.51	0.04	0.63	TRUE
13	GTEx	Brain Cerebellum	DPH1	0.52	0.30	lasso	8	0.31	8.9e-10	9.02	9.2	3.2e-20	-0.29	0.76	0.02	TRUE
14	GTEx	Brain Frontal Cortex BA9	HNRNPA1P16	0.22	-0.01	enet	25	0.06	8.6e-03	-8.78	6.2	4.1e-10	-0.26	0.08	0.06	FALSE
15	GTEx	Breast Mammary Tissue	WDR81	0.18	0.11	lasso	3	0.10	7.4e-06	-4.49	5.8	5.2e-09	-0.13	0.62	0.05	TRUE
16	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	5.04	-5.7	1.0e-08	0.39	1.00	0.00	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	MNT	0.42	0.10	lasso	9	0.14	3.0e-05	-6.55	7.7	1.6e-14	-0.42	0.30	0.20	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RP1-59D14.1	0.22	0.01	lasso	4	0.01	1.3e-01	-6.55	10.1	3.9e-24	-0.50	0.04	0.43	FALSE
19	GTEx	Cells Transformed fibroblasts	DPH1	0.28	0.12	enet	6	0.23	4.0e-17	4.53	5.4	6.2e-08	-0.11	1.00	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	TIMM22	0.27	0.18	lasso	7	0.21	6.7e-16	-4.97	5.7	1.2e-08	0.02	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	SGSM2	0.28	0.32	lasso	5	0.32	6.9e-22	7.74	-7.2	7.1e-13	0.39	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	TIMM22	0.23	0.12	lasso	3	0.14	2.5e-09	-4.97	5.4	7.5e-08	0.01	0.99	0.00	FALSE
23	GTEx	Esophagus Mucosa	RP1-59D14.5	0.14	0.15	lasso	2	0.14	1.3e-09	7.74	-7.7	9.9e-15	0.40	1.00	0.00	FALSE
24	GTEx	Esophagus Muscularis	RP11-667K14.4	0.12	0.03	lasso	6	0.03	8.1e-03	5.53	-8.2	2.6e-16	0.33	0.19	0.06	FALSE
25	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	4.70	-6.8	8.1e-12	0.43	1.00	0.00	TRUE
26	GTEx	Liver	SRR	0.31	0.00	lasso	7	0.00	3.0e-01	1.15	-7.3	3.2e-13	0.35	0.07	0.10	FALSE
27	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	4.82	-5.5	3.4e-08	0.39	1.00	0.00	FALSE
28	GTEx	Ovary	DPH1	0.67	0.38	lasso	6	0.39	1.0e-10	9.02	8.3	1.2e-16	-0.27	0.75	0.01	FALSE
29	GTEx	Pancreas	SERPINF1	0.31	0.08	enet	26	0.06	1.1e-03	3.25	-9.5	1.5e-21	0.15	0.20	0.05	FALSE
30	GTEx	Pituitary	DPH1	0.66	0.47	lasso	6	0.45	7.1e-13	9.02	8.3	1.3e-16	-0.25	0.97	0.00	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	MNT	0.16	0.06	lasso	7	0.04	2.6e-03	4.90	6.0	2.0e-09	-0.30	0.19	0.03	FALSE
32	GTEx	Skin Sun Exposed Lower leg	MNT	0.10	0.09	enet	16	0.08	5.1e-07	4.90	7.8	8.3e-15	-0.40	0.96	0.01	FALSE
33	GTEx	Skin Sun Exposed Lower leg	SGSM2	0.50	0.47	enet	11	0.51	3.3e-48	7.74	-5.3	1.2e-07	0.27	1.00	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	4.61	-6.4	2.0e-10	0.40	1.00	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RP1-59D14.1	0.11	0.07	lasso	4	0.06	1.8e-05	4.90	5.5	3.5e-08	-0.27	0.84	0.02	TRUE
36	GTEx	Skin Sun Exposed Lower leg	RP1-59D14.5	0.32	0.28	lasso	5	0.30	1.8e-25	7.74	-5.7	9.2e-09	0.30	1.00	0.00	FALSE
37	GTEx	Testis	NXN	0.50	-0.01	lasso	9	0.04	7.9e-03	-8.48	-6.3	2.8e-10	0.02	0.01	0.92	TRUE
38	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	6.71	-6.4	1.3e-10	0.36	0.57	0.04	TRUE
39	GTEx	Thyroid	DPH1	0.28	0.23	enet	8	0.24	4.6e-18	9.02	7.6	4.0e-14	-0.22	1.00	0.00	FALSE
40	GTEx	Vagina	SRR	0.18	0.13	lasso	2	0.11	1.6e-03	4.20	-6.4	1.3e-10	0.41	0.11	0.06	FALSE
41	GTEx	Whole Blood	SRR	0.09	0.03	enet	8	0.02	4.5e-03	4.61	-9.0	2.1e-19	0.48	0.65	0.14	FALSE
42	METSIM	Adipose	SERPINF1	0.06	0.00	bslmm	450	0.02	2.5e-04	0.26	7.6	3.7e-14	-0.28	0.19	0.08	FALSE
43	METSIM	Adipose	TIMM22	0.12	0.10	bslmm	440	0.10	3.4e-14	-4.97	5.2	2.3e-07	0.02	1.00	0.00	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	MNT	0.09	0.04	lasso	5	0.06	9.5e-09	-2.45	6.3	3.5e-10	-0.38	1.00	0.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	TIMM22	0.19	0.15	lasso	3	0.16	2.0e-19	-4.97	-5.3	1.2e-07	0.00	1.00	0.00	FALSE
46	YFS	Blood	SGSM2	0.05	0.03	lasso	8	0.03	3.9e-11	-6.97	7.2	4.1e-13	-0.31	1.00	0.00	FALSE
47	YFS	Blood	TIMM22	0.42	0.33	enet	20	0.34	1.8e-116	-4.97	-5.5	5.0e-08	-0.01	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRR	0.11	0.09	lasso	4	0.10	6.8e-09	4.61	-7.3	3.8e-13	0.45	0.67	0.32	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC284009	0.02	0.01	blup	59	0.01	1.4e-02	-1.11	5.5	4.4e-08	-0.32	0.02	0.20	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMG6	0.03	0.01	blup	144	0.01	4.8e-03	14.08	20.0	2.5e-89	-0.67	0.10	0.58	TRUE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	SRR	0.16	0.16	lasso	5	0.16	2.3e-32	4.82	-5.2	1.9e-07	0.35	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	6.71	-6.7	2.1e-11	0.35	0.53	0.10	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMG6	0.08	0.05	blup	144	0.07	1.3e-04	16.04	19.3	1.2e-82	-0.71	0.35	0.45	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	SERPINF1	0.07	0.00	blup	68	0.02	1.0e-03	-1.94	-5.1	3.0e-07	-0.04	0.01	0.14	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRR	0.29	0.26	lasso	2	0.27	1.9e-30	4.82	-5.5	3.0e-08	0.36	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	TIMM22	0.14	0.15	enet	11	0.16	1.5e-17	-4.97	-6.9	5.9e-12	0.00	1.00	0.00	TRUE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SRR	0.34	0.30	lasso	4	0.30	2.9e-13	4.61	-5.3	1.2e-07	0.34	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMG6	0.04	0.01	blup	144	0.02	5.5e-03	1.35	6.2	4.5e-10	-0.30	0.10	0.07	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIMM22	0.11	0.04	blup	49	0.03	4.8e-04	-6.03	-6.5	1.1e-10	-0.03	0.10	0.78	FALSE
60	The Cancer Genome Atlas	Rectum Adenocarcinoma	SRR	0.52	0.32	lasso	3	0.40	1.7e-10	4.61	-9.7	2.4e-22	0.54	0.11	0.73	FALSE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf91	0.22	0.02	enet	17	0.12	4.9e-05	-4.38	5.9	3.8e-09	0.07	0.00	0.10	TRUE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SGSM2	0.13	0.01	blup	81	0.01	1.1e-01	13.70	-9.2	4.6e-20	0.22	0.03	0.05	TRUE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SRR	0.35	0.07	enet	11	0.14	1.1e-05	4.82	-13.8	4.0e-43	0.65	0.01	0.94	TRUE