Hub : Genes

TCF25

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1290	0.0440	1.7e-06	0.115	NA	0.088	NA	0.085	4.4e-08	NA	1.7e-06	NA	2.5e-06
2	GTEx	Ovary	0.2210	0.1010	5.4e-03	0.125	NA	0.079	NA	0.127	5.6e-04	NA	5.4e-03	NA	5.1e-04
3	GTEx	Thyroid	0.1310	0.0530	4.1e-04	-0.003	NA	0.033	NA	0.001	7.6e-01	NA	1.4e-03	NA	2.4e-01
4	GTEx	Whole Blood	0.0470	0.0230	8.5e-03	0.016	NA	0.005	NA	0.011	1.2e-02	NA	9.2e-02	NA	2.8e-02
5	YFS	Blood	0.0329	0.0138	5.6e-05	0.015	0.020	0.020	0.021	0.023	1.0e-05	2.0e-07	2.5e-07	1.1e-07	4.8e-08
6	TCGA	Thyroid Carcinoma	0.0270	0.0150	2.4e-03	0.013	0.011	0.012	NA	0.009	1.6e-02	2.8e-02	2.0e-02	NA	4.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.2	3.5	9.8	-3.1	0.6	-0.2	-1.9	-1.3	2.4
Bipolar Disorder or Schizophrenia	1.7	4.2	12.2	-3.5	0.4	-0.5	-1.6	-1.9	2.5
Depressed Affect (Nagel 2018)	0.8	1.6	4.7	-0.4	1.8	2.2	0.8	-0.3	1.1
Depression (Nagel 2018)	0.1	0.2	0.5	0.1	-0.1	0.5	0.7	-0.4	0.1
Intelligence (Savage-Jansen 2018)	1.1	3.4	7.8	2.7	1.2	1.7	2.8	0.9	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	1.9	-0.7	1.1	1.4	1.1	-0.7	0.9
Schizophrenia (2018)	0.7	1.4	4.1	-2.0	-0.0	-0.8	-0.6	-1.3	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.6	1.1	-0.0	-0.8	1.1	1.1	-1.6
Worry (Nagel 2018)	0.2	0.4	0.9	-0.7	0.0	0.0	0.3	-1.0	0.9
Alzheimer’s Disease (in mother)	2.5	3.0	7.2	0.4	-2.7	-1.7	-2.2	-1.5	-0.6
Alzheimer’s Disease (in father)	2.3	2.5	6.0	-1.5	-1.9	0.0	-0.2	-2.5	1.7
Alzheimer’s Disease (including proxy)	3.9	5.6	13.8	-0.7	-3.7	-1.9	-2.5	-3.0	0.6
Crohns Disease (2017)	1.3	2.9	8.3	-0.9	2.9	1.5	1.1	1.9	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	3.2	-0.8	1.8	0.1	0.4	1.6	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.7	-0.1	0.3	-0.9	-0.4	0.6	-0.3
Major Depression (MDD)	1.0	1.2	2.8	-0.2	-0.6	-0.8	1.2	1.3	-1.7
Reaction Time	0.4	0.7	1.5	-0.6	0.6	1.2	0.8	-0.2	1.1
Verbal and Numeric Reasoning (VNR)	2.2	5.3	13.9	3.7	1.1	1.0	2.6	2.4	-1.9
Breast Cancer	4.0	9.5	14.6	-3.3	-2.0	0.6	-3.6	-3.8	3.8
Ovarian Cancer	1.8	2.4	6.3	-1.1	-2.1	-0.5	-2.5	-1.3	0.8
Prostate Cancer	1.0	1.5	3.3	-1.4	-1.1	-0.4	-1.8	-1.2	0.8
Age at First Birth	3.0	4.3	8.1	1.5	2.6	2.8	2.0	1.8	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	-0.1	0.1	-0.2	0.6	0.9	-0.4
Coronary Artery Disease (CAD)	1.1	1.3	3.4	-0.6	0.3	-1.6	-1.2	-0.3	1.9
Crohns Disease (2012)	1.6	2.6	6.5	0.2	2.0	2.5	1.7	1.4	0.5
Mean Putamen Volume	0.9	1.0	2.7	-1.3	1.6	0.7	-0.2	0.6	1.0
Fasting Glucose	1.7	2.1	5.8	1.2	1.4	0.5	1.1	2.4	-1.4
HbA1C	0.9	1.0	4.0	-0.6	0.6	0.8	-2.0	0.2	0.9
HDL Cholesterol	0.3	0.5	1.9	-0.3	-0.7	1.4	-0.8	0.3	0.1
LDL Cholesterol	0.2	0.4	0.7	-0.4	-0.4	-0.7	-0.8	-0.7	-0.2
Lupus	0.4	0.6	1.5	-0.4	-1.2	-0.8	0.5	-0.9	0.7
Neuroticism (2016)	1.0	1.5	5.3	0.6	1.1	1.2	2.3	0.4	-0.4
Primary Biliary Cirrhosis	1.2	1.7	3.0	1.0	-1.5	-1.7	-1.4	-0.5	-1.1
Rheumatoid Arthritis	1.1	1.5	3.2	-1.8	0.7	-1.8	-1.2	0.5	0.7
Schizophrenia (2014)	0.7	1.5	4.8	-2.2	0.4	-0.8	-0.8	-1.1	1.4
Triglycerides	0.2	0.3	0.7	0.8	0.5	-0.7	0.6	-0.4	-0.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	6.6	2.0	0.0	-2.6	0.2	0.0	-1.5
Ulcerative Colitis	0.3	0.4	1.0	-1.0	-0.2	-0.4	-0.8	-0.2	0.7
Blood Eosinophil Count	0.4	3.4	10.4	-1.0	1.6	3.2	1.3	-0.9	1.9
Blood Platelet Count	0.7	8.1	19.4	1.0	3.1	4.2	4.4	1.3	-0.2
Blood Red Count	0.9	8.5	16.6	3.5	-3.9	-1.5	-1.4	1.4	-4.1
Blood White Count	1.0	7.1	16.0	2.1	-4.0	-2.8	-3.3	-1.4	-1.1
Heel T-Score	2.7	21.8	50.6	7.1	2.0	-0.3	3.2	5.4	-6.0
BMI	0.6	3.5	7.6	2.0	0.4	0.2	1.4	2.7	-2.8
Height	0.7	13.8	30.6	5.5	4.3	0.8	4.5	2.9	-2.0
Waist Hip Ratio (WHR)	0.2	1.0	1.6	1.2	-0.5	-1.3	0.6	1.3	-0.8
Systolic Blood Pressure	0.4	2.2	3.9	-1.8	1.5	-1.7	-0.8	0.4	2.0
Smoking Status	0.3	0.7	1.7	-0.8	-0.4	-1.3	0.0	-0.8	1.1
Allergy or Eczema	0.3	0.7	1.4	-1.2	0.3	0.9	-0.1	-0.8	1.2
Cardiovascular Disease	0.5	1.7	3.8	1.4	0.2	-1.9	1.7	0.9	-0.8
Hypothyroidism (self reported)	0.3	0.7	1.8	-1.3	0.3	0.4	0.1	-0.7	1.2
Respiratory disease	1.5	3.3	6.9	-1.0	2.6	2.4	1.5	-0.3	2.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.8	0.1	-0.5	-0.9	-0.1	-0.6	-0.2
Lung FEV1/FVC ratio	0.9	4.8	10.6	2.0	-3.2	-3.3	-1.1	0.2	-1.7
Lung FVC	0.5	2.6	6.2	2.5	-0.8	-1.5	0.5	0.9	-2.3
Neuroticism	1.0	2.5	4.1	-1.7	1.1	2.0	0.6	-1.5	2.0
Chronotype (morning person)	0.4	0.9	1.7	-0.2	1.2	1.3	-0.4	-0.6	1.2
Hair Pigment	82.5	2353.1	4830.2	-58.7	39.6	69.5	34.5	-18.4	52.4
Tanning	54.7	667.8	1927.2	-0.4	-21.7	-35.8	-43.9	-16.8	6.7
Hand grip strength (left)	1.4	3.7	9.7	3.1	1.2	0.9	2.4	1.3	-1.6
Number of treatments/medications taken	1.2	2.1	4.3	-1.8	1.3	1.5	0.2	-1.1	2.1
Average weekly spirits intake	0.3	0.3	0.7	0.6	-0.4	-0.9	-0.2	0.5	-0.7
Sensitivity / hurt feelings	0.0	0.0	0.1	0.2	-0.2	-0.2	0.1	-0.3	0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.7	0.0	-0.1	0.3	-0.4	-0.5
Hearing difficulty/problems: Yes	0.3	0.4	0.9	1.0	0.2	-0.9	0.6	0.1	-0.3
Relative age of first facial hair	2.7	5.5	10.7	-3.2	1.7	2.7	-0.7	-1.2	3.3
Other serious medical condition/disability diagnosed by doctor	4.3	5.6	10.0	-3.2	-1.7	-0.4	-2.1	-3.0	2.7
Ever used hormone-replacement therapy (HRT)	2.1	2.7	6.0	-1.5	-0.7	-2.4	-2.4	-0.6	1.1
Ever had hysterectomy (womb removed)	1.5	1.6	5.2	-2.3	0.7	1.0	-0.7	0.4	1.6
Systolic blood pressure, automated reading	0.8	2.4	4.4	-2.1	2.0	0.1	-1.0	1.5	1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.4	1.6	-1.4	-0.2	0.0	0.8	-1.6
Angina	2.3	3.1	5.0	-2.2	-1.1	-2.0	-1.6	-1.6	1.8
Medication for hormone replacement therapy	0.6	0.7	1.6	-0.9	1.3	-0.2	-0.8	0.6	0.8
Vitamin and mineral supplements	1.8	2.5	5.3	2.3	1.2	0.8	1.3	1.9	-1.5
Supplements: Zinc	1.9	2.1	5.7	-1.8	-0.5	-1.2	-2.4	-0.8	1.1
Medication: Co-codamol	0.4	0.5	1.3	-0.2	0.1	-0.6	-1.1	-1.1	0.4
Medication: Metformin	2.0	2.8	5.6	2.4	-0.4	-0.5	1.6	1.6	-2.4
Diabetes (father)	0.3	0.3	0.7	-0.0	0.2	0.6	0.7	0.8	-0.6
Diabetes (mother)	0.3	0.3	1.7	-0.3	0.4	-1.3	0.0	0.2	0.1
Severe depression (siblings)	0.9	1.0	2.1	-1.2	-0.9	0.7	-1.4	-0.8	0.6
Pack years adult smoking proportion	0.5	0.7	1.5	0.8	-0.6	-0.9	0.3	0.9	-1.2
Impedance of leg (right)	0.2	1.1	2.1	1.3	0.8	0.4	1.5	0.9	-1.0
Leg fat-free mass (left)	0.7	3.9	8.4	2.9	2.1	0.0	2.3	1.9	-1.3
Trunk fat percentage	1.9	7.5	19.0	3.5	-0.7	-1.9	1.4	2.9	-4.4
Hand grip strength (right)	1.3	3.5	10.8	3.3	-0.5	-1.3	1.5	1.0	-2.3
Townsend deprivation index at recruitment	1.0	1.5	3.2	-1.4	-1.8	-0.7	-0.5	-1.5	0.7
Current tobacco smoking	1.2	2.0	4.2	2.1	-0.3	-0.9	1.5	1.3	-1.8
Average weekly fortified wine intake	0.9	1.0	2.4	-1.1	0.5	0.8	0.1	-1.3	1.6
Maternal smoking around birth	1.6	2.4	5.0	1.5	-1.0	-1.8	0.0	1.6	-2.2
Fed-up feelings	0.3	0.5	1.4	-0.1	-1.2	-0.0	-0.3	-1.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.3	-0.3	0.1	0.7	-0.4	-0.6
Relative age voice broke	0.7	1.1	2.8	-1.7	1.0	1.1	-0.2	-0.1	1.1
Taking other prescription medications	1.1	1.7	3.2	-1.8	1.4	1.4	-0.5	-0.2	1.6
Age when periods started (menarche)	1.0	2.5	7.4	2.1	-1.0	-2.7	-0.2	0.3	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-0.6	0.5	-0.3	-1.0	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.8	2.2	1.1	1.4	1.6	1.5	-1.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	5.7	0.9	-1.1	-2.4	0.9	1.2	-1.6
Qualifications: CSEs or equivalent	1.6	2.1	4.5	1.7	0.1	-1.3	-0.9	1.7	-2.1
Serious illness, injury or assault to yourself	0.7	0.9	1.5	-1.2	-1.0	-0.1	-0.7	-1.0	1.1
High blood pressure	0.1	0.3	0.7	-0.0	0.9	-0.6	0.5	0.3	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.1	-0.6	-0.2	-0.5	-0.6	0.2
Multivitamins +/- minerals	1.3	1.7	4.5	-1.5	-0.8	-0.1	-0.9	-2.1	1.4
Stomach or abdominal pain in last month	1.9	2.4	4.3	-2.0	-2.1	0.7	-1.4	-1.6	1.0
Supplements: Glucosamine	0.3	0.4	1.9	-0.3	0.5	1.4	-0.5	-0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.2	-0.3	-0.5	-0.6	-0.5	0.1
Medication: Atenolol	1.6	2.0	6.8	-1.9	0.5	-0.3	-0.4	-1.0	2.6
Medication: Levothyroxine sodium	0.3	0.5	1.0	-1.0	0.5	0.1	-0.7	-0.6	0.9
Sitting height	0.3	1.9	5.4	1.2	2.3	0.0	2.0	-0.0	0.5
Chronic bronchitis/emphysema (father)	0.0	0.1	0.2	-0.4	0.2	0.1	-0.1	-0.2	0.2
High blood pressure (mother)	0.5	0.6	2.3	0.6	0.2	-0.9	1.5	0.2	-0.6
Body mass index (BMI)	0.4	1.6	3.9	1.3	-0.3	-0.8	0.7	1.6	-2.0
Impedance of leg (left)	0.3	1.3	3.1	1.8	-0.2	-0.0	1.4	0.5	-1.6
Leg predicted mass (left)	0.7	3.8	8.7	3.0	2.0	0.0	2.3	1.8	-1.3
Trunk fat mass	1.5	6.2	12.5	3.5	0.3	-1.2	2.0	2.7	-3.5
Waist circumference	1.1	4.1	7.8	2.4	0.9	-0.8	2.1	2.8	-2.3
Number of incorrect matches in round	4.5	7.5	15.0	-3.5	3.9	2.5	-1.0	-0.1	3.3
Past tobacco smoking	2.0	3.6	9.0	2.2	0.4	-0.2	1.6	2.2	-3.0
Alcohol usually taken with meals	0.1	0.1	0.3	-0.2	-0.0	0.3	-0.1	-0.6	0.4
Nervous feelings	0.7	1.3	2.5	-1.4	0.3	1.1	-0.1	-1.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.0	-1.0	-2.2	-0.9	-2.0	-1.6	0.1
Hearing difficulty/problems with background noise	1.2	1.9	4.8	-0.9	-0.6	-1.4	-0.8	-2.2	1.7
Hair/balding pattern: Pattern 2	1.0	1.2	3.7	-1.9	1.3	-0.8	0.4	0.2	1.1
Had menopause	9.7	12.1	22.9	-4.8	-1.8	-1.4	-4.4	-2.8	4.1
Had other major operations	1.5	1.8	3.0	1.2	1.3	1.1	1.0	1.7	-1.6
Forced vital capacity (FVC)	1.7	6.4	23.3	4.8	0.3	-0.6	2.2	1.0	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	8.8	3.0	1.0	0.8	1.3	1.7	-2.4
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	2.9	-1.7	-1.5	-0.9	-1.6	-1.5	1.2
Qualifications: None of the above	0.6	1.4	3.0	-1.5	-1.3	-1.7	-1.1	-0.0	0.2
Financial difficulties in last 2 years	0.4	0.5	1.5	0.7	-1.2	-0.4	-0.2	-0.3	-0.7
Mouth/teeth dental problems	0.6	1.0	1.7	1.3	0.1	-0.9	-0.8	0.9	-1.3
Heart attack	1.2	1.5	3.2	-1.6	1.8	0.7	-0.2	0.8	1.5
Allergy	0.0	0.1	0.3	-0.1	-0.2	-0.4	-0.6	0.3	-0.0
Pain all over the body in last month	0.3	0.3	1.5	-0.2	-0.2	0.3	-1.2	0.4	-0.3
Diabetes (self-reported)	0.3	0.4	0.7	0.8	-0.7	-0.5	-0.6	0.2	-0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.4	0.2	-0.6	-0.7	-0.1	0.3
Medication: Ramipril	0.3	0.4	1.5	-0.0	0.3	-0.3	-1.0	1.2	-0.2
Medication: Simvastatin	1.7	2.5	8.9	-0.2	-2.3	-3.0	-0.5	-0.7	-0.5
Fluid intelligence score	1.5	3.0	7.3	2.7	0.9	1.5	2.2	1.4	-1.0
Illnesses of siblings	2.8	3.9	6.3	2.3	0.9	1.3	1.8	2.5	-2.5
Neuroticism score	0.3	0.6	2.1	-0.1	0.2	1.4	0.5	-1.0	0.3
Weight	1.0	5.1	10.2	3.2	1.5	-0.2	2.8	2.3	-2.2
Impedance of arm (right)	0.2	1.0	3.3	-1.0	-0.3	-0.7	-1.8	-1.0	0.5
Arm fat percentage (right)	0.5	1.8	4.6	1.2	0.1	-1.4	0.1	1.8	-2.1
Trunk fat-free mass	0.9	5.2	11.3	2.1	3.4	1.7	3.4	1.1	0.6
Hip circumference	0.8	3.5	6.7	2.3	1.8	0.4	2.6	1.8	-1.5
Time employed in main current job	3.2	3.7	6.9	-2.2	2.2	2.6	-0.2	-0.6	2.3
Alcohol intake versus 10 years previously	0.5	0.8	2.4	-1.0	0.9	1.5	0.0	-0.5	0.7
Father’s age at death	0.5	0.6	1.3	-0.7	-1.0	0.2	-0.5	-1.1	0.9
Worrier / anxious feelings	0.2	0.4	1.4	-0.2	-0.2	1.2	-0.1	-0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	-1.0	-0.4	0.4	-1.1	-1.3	0.7
Falls in the last year	0.8	1.1	3.7	0.5	-1.9	-1.0	-0.5	-0.8	-1.0
Hair/balding pattern: Pattern 3	2.7	4.0	8.6	2.9	-0.2	1.2	1.9	1.4	-2.8
Number of live births	3.8	5.3	7.4	-2.1	-2.7	-1.7	-2.4	-2.5	2.3
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	22.6	4.8	-0.8	-1.9	1.2	0.8	-3.2
Pulse rate	0.7	1.2	2.4	1.0	0.4	-1.2	0.0	1.4	-1.5
Happiness	0.7	0.9	2.4	-1.5	-0.2	0.7	0.2	-1.0	1.2
Noisy workplace	1.0	1.2	3.1	-1.7	0.0	0.2	0.0	-1.2	1.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	1.4	1.6	1.3	1.2	0.4	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.2	-0.5	-0.6	1.2	0.2	-1.8	1.6
Mouth/teeth dental problems: Dentures	0.4	0.7	2.7	-0.8	-1.6	-0.7	-0.1	-0.6	-0.2
Asthma	1.4	2.8	6.5	-1.6	2.5	1.7	0.7	-0.4	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	8.1	0.2	2.7	2.5	2.8	0.3	0.7
Medication: Cholesterol lowering	0.6	0.9	2.1	0.9	-1.4	-0.6	0.5	0.3	-1.4
Depression (self-reported)	0.7	0.9	3.4	-0.7	0.7	1.9	-0.1	-0.3	0.9
Medication: Lansoprazole	0.4	0.4	0.8	-0.4	-0.8	-0.8	-0.6	-0.0	-0.9
Prospective memory result	0.5	0.6	1.3	0.2	0.8	-0.8	-0.3	1.1	-0.8
Lung cancer (father)	0.4	0.5	2.0	0.7	0.2	-1.4	0.3	0.4	-0.2
Illnesses of mother	0.1	0.1	0.5	-0.4	-0.3	0.7	-0.1	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	14.2	3.8	0.3	-0.8	0.8	0.7	-2.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	-0.5	0.2	0.8	0.9	-1.1	0.8
Impedance of arm (left)	0.5	2.1	3.9	1.4	-1.7	-1.6	-1.2	0.3	-2.0
Arm fat mass (right)	0.6	2.5	4.5	1.9	0.6	-1.1	1.2	2.0	-2.1
Trunk predicted mass	0.9	5.0	11.2	2.0	3.3	1.7	3.2	1.0	0.8
Standing height	1.0	10.1	21.4	4.5	3.8	1.4	4.6	1.6	-0.8
Length of working week for main job	2.2	2.4	7.7	1.6	-1.0	-0.2	0.3	1.8	-2.8
Exposure to tobacco smoke at home	0.4	0.5	2.2	-0.3	-0.1	1.5	0.3	-0.4	0.5
Breastfed as a baby	0.4	0.5	1.3	-0.6	-0.2	-0.5	-1.0	1.1	-0.1
Tense / ‘highly strung’	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.1	-0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.5	-0.6	0.9	-0.4	-0.0	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	1.4	-1.5	0.7	0.9	-0.4	-0.9
Birth weight of first child	1.4	2.6	6.9	-1.4	0.3	0.3	0.7	-2.4	2.6
Peak expiratory flow (PEF)	1.7	3.9	11.4	3.4	-0.2	-2.1	1.1	0.9	-2.4
Pulse wave reflection index	1.6	1.9	5.4	-1.1	-0.4	0.9	0.4	-2.3	2.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-1.1	-0.1	0.8	0.3	-0.0	0.6
Loud music exposure frequency	0.9	0.9	1.7	-0.7	1.0	1.0	0.7	-1.0	1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	1.0	1.0	0.1	-0.6	0.9	-0.4
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.2	-0.2	1.6	1.8	2.1	0.4	0.9
Blood clot in the leg (DVT)	3.3	4.2	7.9	2.1	-2.7	-2.4	-0.4	0.1	-2.8
Medication: Paracetamol	1.5	2.5	5.0	-2.0	0.6	1.2	-0.3	-1.9	2.2
Headache pain in last month	0.6	1.1	2.8	-1.2	-0.1	-0.4	-0.4	-1.7	1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.8	-0.2	1.3	1.1	0.1	0.1	0.7
Glaucoma (self-reported)	0.8	1.0	1.8	1.2	0.1	-1.4	-0.2	0.9	-1.3
Gout (self-reported)	0.2	0.3	1.2	1.1	0.2	-0.4	0.6	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.8	-1.7	0.7	0.1	-1.4	-1.4	1.6
Medication: Amlodipine	0.4	0.6	1.1	-0.4	-0.9	-0.8	0.1	-1.1	0.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.1	0.3	2.3	0.8	1.8	1.7	0.1
Birth weight	2.1	4.6	7.2	-2.4	-2.2	-0.9	-1.8	-2.7	2.4
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.9	-0.3	2.2	1.7	-1.3	-0.3	0.7
High blood pressure (siblings)	2.4	3.4	5.3	-1.2	-2.3	-2.1	-1.9	-2.3	0.9
Forced vital capacity (FVC), Best measure	1.2	4.2	16.1	4.0	1.1	-0.2	1.4	0.9	-2.3
Body fat percentage	1.4	5.4	13.5	2.8	-0.4	-1.5	1.2	2.6	-3.7
Leg fat percentage (right)	0.5	1.9	3.8	1.3	0.3	-0.6	1.2	2.0	-1.9
Arm fat-free mass (right)	1.3	6.6	14.3	3.7	2.0	0.7	3.8	2.1	-1.6
Exposure to tobacco smoke outside home	0.6	0.8	1.5	1.1	0.1	0.7	0.4	1.1	-1.2
Comparative body size at age 10	1.6	4.5	9.2	-2.1	-3.0	0.2	-2.7	-1.9	1.6
Number of full brothers	0.1	0.1	0.3	0.2	0.3	0.2	-0.1	0.5	-0.1
Worry too long after embarrassment	0.3	0.5	0.8	0.7	0.1	0.9	0.9	0.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.7	-1.3	-1.9	0.4	-1.3	-1.3	0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-0.8	-0.8	0.3	1.1	-1.1	0.5
Number of children fathered	3.6	4.0	8.4	-2.4	1.6	0.9	-2.1	-1.5	2.9
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	6.6	-2.6	0.4	1.1	-1.8	-1.5	1.6
Age at first live birth	0.9	1.6	3.7	-0.6	1.0	1.9	0.6	-1.4	1.4
Pulse wave peak to peak time	0.6	0.7	1.7	0.9	0.3	-0.5	-0.6	1.3	-0.9
Health satisfaction	0.3	0.3	1.5	-1.2	-0.4	0.0	0.6	-0.2	0.2
Shortness of breath walking on level ground	1.5	1.7	3.6	1.3	-1.3	-1.3	0.9	0.9	-1.9
Qualifications: College or University degree	0.7	2.1	5.0	1.7	1.9	1.0	2.2	0.3	-0.2
Eye problems/disorders: None of the above	0.3	0.4	1.7	-0.2	-0.4	1.3	-0.0	-0.1	0.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.8	-1.6	-0.2	0.9	-0.7	-2.2	2.0
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.2	-0.7	-0.5	-0.8	-0.3	-0.5
Medication for pain relief, constipation, heartburn	1.0	1.7	2.8	1.6	-1.4	-1.5	-0.4	0.9	-1.7
Neck or shoulder pain in last month	2.5	3.5	8.9	0.4	-2.6	-3.0	-1.4	-1.3	-1.2
Medication: Blood pressure	0.3	0.6	1.9	0.2	-1.4	-0.9	-0.2	-0.7	0.1
Angina (self-reported)	2.3	3.0	5.8	-1.9	-1.2	-2.4	-1.5	-1.5	1.5
Migraine (self-reported)	0.2	0.3	0.9	0.2	-0.5	-0.4	-0.6	-0.9	-0.0
Medication: Ibuprofen	2.2	2.7	7.0	-0.1	2.1	2.0	2.6	0.0	0.9
Medication: Allopurinol	0.5	0.7	2.2	0.6	0.7	1.5	0.4	-0.8	0.5
Medication: Omeprazole	2.8	3.4	6.1	-2.2	1.1	1.7	-2.5	-1.0	2.1
Medication: Seretide 50 evohaler	1.6	1.8	6.2	-0.0	1.3	2.5	1.6	0.0	0.5
Mean time to correctly identify matches	1.1	2.1	6.1	-2.0	-0.1	0.8	-0.2	-1.3	2.5
Heart disease (mother)	0.3	0.3	1.0	0.1	-0.9	-1.0	-0.1	-0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	7.8	-1.3	-2.2	-2.8	-1.6	-1.7	0.4
Whole body fat mass	1.2	5.1	9.6	3.0	0.4	-1.3	1.9	2.5	-3.1
Leg fat mass (right)	1.1	4.1	6.9	2.4	1.1	-0.4	2.2	2.6	-2.4
Arm predicted mass (right)	1.0	5.1	11.0	3.3	1.8	0.5	3.3	1.8	-1.4
Pulse rate, automated reading	0.1	0.2	0.8	0.2	-0.3	-0.4	-0.2	0.6	-0.9
Alcohol intake frequency.	0.9	2.2	9.2	-3.0	-0.6	0.7	-1.2	-0.4	1.1
Comparative height size at age 10	1.7	9.6	20.8	2.3	4.6	4.1	3.5	1.5	0.4
Number of full sisters	0.4	0.5	1.0	0.2	0.2	-1.0	0.8	0.8	-0.9
Suffer from ‘nerves’	0.3	0.5	1.4	0.0	-1.2	0.9	0.4	-0.8	0.1
Overall health rating	0.4	0.8	2.7	-1.6	-0.6	0.0	-0.9	-0.9	0.5
Chest pain or discomfort	0.7	1.0	2.6	0.4	-1.6	-1.2	0.8	0.2	-0.9
Had major operations	0.9	1.0	2.3	-1.1	1.5	1.2	0.2	-0.1	1.2
Age at last live birth	1.1	1.6	3.0	-1.7	0.7	1.4	-0.8	-1.0	1.6
Family relationship satisfaction	1.8	2.2	5.7	-0.7	2.4	1.5	1.9	0.2	1.0
Leg pain on walking	0.8	1.0	3.4	0.6	-0.7	-1.8	0.2	0.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	1.0	0.3	1.0	0.5	0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	-0.4	-1.1	-0.8	-1.3	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.0	1.4	-1.7	-1.2	-0.1	0.6	-1.7
Medication: Aspirin	0.2	0.3	0.8	-0.3	0.6	-0.9	0.5	0.5	0.2
Supplements: Vitamin C	2.0	2.4	4.4	-2.0	-2.1	-1.7	-1.1	-1.2	0.7
Knee pain experienced in last month	1.0	1.5	3.7	-0.6	-1.0	-0.7	-1.7	-1.9	0.8
Hypertension (Self-reported)	0.3	0.8	1.2	0.9	1.0	-1.0	1.0	1.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.6	-0.5	-1.2	-0.8	-1.9	-0.3	-0.4
Illnesses of father: Heart disease	0.9	1.3	1.6	-1.1	-0.9	-1.1	-1.2	-1.1	1.3
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-0.6	1.2	1.1	0.7	0.9	0.2
Smoking status: Previous	2.5	3.7	10.2	-2.7	0.8	1.0	-1.0	-1.6	3.2
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	9.2	3.0	2.2	0.4	2.8	1.7	-1.7
Whole body fat-free mass	0.8	4.5	9.1	2.5	2.8	1.1	3.0	1.4	-0.2
Leg fat-free mass (right)	0.6	3.3	8.3	2.9	1.6	0.1	2.2	1.5	-1.2
Arm fat percentage (left)	1.0	3.8	9.8	2.1	-0.8	-1.9	0.2	2.1	-3.1
Average weekly red wine intake	0.5	0.7	2.0	-0.5	-1.4	-0.2	-0.2	-1.2	0.5
Handedness (chirality/laterality): Left-handed	1.8	2.1	8.8	0.5	3.0	0.9	0.7	1.5	0.4
Mood swings	1.2	2.1	3.7	-1.7	0.9	1.4	-0.7	-1.8	1.9
Loneliness, isolation	0.2	0.2	0.6	0.7	0.1	0.3	0.3	-0.8	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	1.5	-1.2	-0.0	0.1	-0.6	-0.6	0.7
Ever had bowel cancer screening	3.7	4.4	9.9	-3.1	-0.5	-0.0	-1.4	-2.1	3.1
Diabetes diagnosed by doctor	0.4	0.7	1.8	1.3	-0.7	-0.5	-0.1	0.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.8	-1.0	1.0	-0.2	0.9	-0.4	1.4
Friendships satisfaction	2.0	2.5	5.2	-1.9	2.3	1.7	1.2	-0.0	1.4
Qualifications: nursing, teaching	0.6	1.0	3.1	0.9	1.2	1.8	0.2	-0.6	0.2
Commuting to job workplace: Walk	0.8	0.9	2.3	1.5	-0.1	-0.1	1.1	1.0	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.2	0.6	-0.8	0.2	-0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.6	-2.0	0.1	0.1	-1.9	-1.4	2.1
Medication for cholesterol	1.4	2.1	7.2	0.1	-2.7	0.5	-0.9	-1.9	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.8	-1.3	-0.4	-0.3	-0.7	-0.6	0.5
Back pain experienced in last month	0.9	1.3	3.3	-1.8	0.4	0.2	-0.1	-1.5	1.5
Mineral and other dietary supplements	2.8	3.8	8.4	2.9	1.3	0.9	2.0	2.0	-2.0
Breast cancer (self-reported)	1.2	1.4	3.0	1.2	1.3	1.0	0.6	1.7	-1.1
Asthma (self-reported)	1.3	2.6	6.8	-1.5	2.6	1.6	0.4	-0.3	2.0
Osteoporosis (self-reported)	1.4	1.8	4.5	-1.1	-1.0	-2.1	-1.8	0.8	0.1
Osteoarthritis (self-reported)	1.8	2.3	7.0	-1.4	-1.2	-0.5	-2.6	-1.5	1.0
Medication: Aspirin	0.4	0.5	1.0	-0.0	0.9	-1.0	0.9	0.7	0.1
Medication: Gliclazide	0.4	0.5	1.8	-0.1	1.3	0.4	0.6	0.8	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	0.9	0.0	-0.7	-0.5	1.0	-1.3
Smoking status: Current	0.8	1.3	3.1	1.8	-0.5	-1.0	1.1	0.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	1.5	0.5	-0.3	0.3	1.1	-1.3
Whole body water mass	0.8	4.4	9.1	2.6	2.8	1.0	3.0	1.4	-0.3
Leg predicted mass (right)	0.6	3.4	9.1	3.0	1.5	0.0	2.3	1.5	-1.4
Arm fat mass (left)	0.8	3.4	7.3	2.4	0.1	-1.2	1.1	2.2	-2.7
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	-1.4	0.4	-0.8	-0.7	-0.9	1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.9	1.2	-0.0	-0.2	1.4	0.6	-0.8
Miserableness	1.1	1.9	4.7	0.9	2.2	2.1	1.1	0.4	0.1
Guilty feelings	0.1	0.1	0.3	0.5	-0.0	-0.0	0.1	-0.1	-0.6
Wears glasses or contact lenses	1.1	1.2	2.2	-1.2	-0.1	-0.8	-1.5	-1.3	1.2
Ever taken oral contraceptive pill	0.6	0.7	1.4	0.8	1.0	1.2	0.9	0.6	-0.3
Hearing aid user	0.7	0.8	2.2	-0.5	-0.1	1.5	-0.3	-1.1	1.1
Mother’s age at death	0.6	0.8	4.1	0.2	-0.6	-2.0	-0.2	0.1	0.2
Financial situation satisfaction	1.4	1.8	4.3	-1.4	-1.3	0.6	-0.8	-2.1	1.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.7	0.8	-0.4	-0.9	-0.0	0.4
Commuting to job workplace: Public transport	0.8	1.0	2.9	0.2	1.7	1.3	0.8	0.5	0.5
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	0.4	-0.4	-1.7	-1.6	-0.1	-0.6
Medication: Blood pressure	1.4	2.7	6.5	1.3	2.5	-1.3	1.5	2.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	-0.9	-0.1	-0.5	-1.2	-0.6	0.8
Supplements: Fish oil (including cod liver oil)	2.2	2.9	6.4	-2.2	-0.8	-0.3	-0.5	-2.5	2.2
High cholesterol (Self-reported)	0.7	1.2	3.5	0.5	-1.7	-1.9	-0.7	0.2	-0.7
Medication: Bendroflumethiazide	1.0	1.5	4.5	0.5	2.1	1.4	1.1	0.8	0.7
Medication: Paracetamol	2.2	3.3	7.1	-2.3	-0.3	1.2	-0.4	-2.7	2.4
Medication: Lisinopril	1.1	1.5	3.8	-0.4	2.0	0.9	0.9	-0.9	1.6
Medication: Atorvastatin	0.9	1.2	2.6	0.8	1.0	-0.5	1.4	1.6	-0.8
Illnesses of father: High blood pressure	1.0	1.3	3.1	1.1	0.1	-1.8	0.8	1.3	-1.1
Alcohol drinker status: Never	0.8	0.9	2.0	0.4	-1.1	-1.4	-0.1	0.7	-1.4
Ever smoked	0.7	1.2	2.4	-0.4	-0.9	-0.9	-0.9	-1.3	1.6
Basal metabolic rate	0.9	5.2	9.9	3.0	2.7	0.7	3.1	1.9	-1.0
Leg fat percentage (left)	0.6	2.1	5.2	1.6	-0.3	-0.9	1.2	1.6	-2.3
Arm fat-free mass (left)	1.0	5.1	11.4	2.5	2.9	1.1	3.4	1.7	-0.7
Number of operations (self-reported)	1.1	1.7	4.6	-0.9	2.1	1.8	-0.6	-0.1	0.9
Average weekly beer plus cider intake	0.6	0.9	2.7	1.6	0.2	-0.1	0.9	0.7	-1.1
Irritability	0.2	0.3	0.9	-0.6	-0.3	0.4	0.3	-1.0	0.4
Risk taking	0.2	0.3	1.2	-0.5	-0.5	1.1	-0.5	-0.1	0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.7	-1.1	-0.5	0.8	-0.6	-1.7	0.9
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-1.2	-0.5	0.5	-0.1	-1.0	0.8
Age started oral contraceptive pill	0.2	0.2	0.7	-0.9	0.2	0.5	-0.2	0.1	0.1
Diastolic blood pressure, automated reading	1.4	4.2	11.3	1.5	3.4	1.5	1.8	2.5	-0.3
Ever depressed for a whole week	0.2	0.3	0.9	-0.5	0.4	1.0	0.2	0.2	0.3
Unable to work because of sickness or disability	1.6	2.0	6.6	-0.4	-2.6	-1.3	-1.3	-1.4	0.1
Commuting to job workplace: Cycle	0.5	0.7	1.5	0.8	1.2	0.7	1.1	0.3	-0.2
Myopia	0.5	0.7	1.6	-0.6	-0.7	1.3	-0.8	-0.2	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	0.2	-0.8	0.9	-0.3	-0.7	-0.5
Cholesterol lowering medication	1.5	2.3	10.8	-0.5	-1.4	-3.3	-0.9	-0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	5.2	-2.0	1.1	1.8	-2.3	-0.4	1.7
Pain experienced in last month	0.8	1.3	4.0	1.0	1.0	0.4	1.2	2.0	-0.7
Supplements: Calcium	1.5	1.7	5.5	-0.8	-2.3	-1.7	-1.0	0.0	-0.3
Basal cell carcinoma (self-reported)	1.9	2.2	5.1	0.7	1.7	1.9	2.2	1.0	-0.8
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.5	-1.5	1.9	0.6	-0.0	0.8	1.4
Deep venous thrombosis (DVT) (self-reported)	2.9	3.7	7.6	1.7	-2.7	-2.5	-0.6	-0.2	-2.3
Heart disease (siblings)	1.4	1.7	4.6	-2.1	-0.4	-0.1	-1.1	-1.0	1.8
Alcohol drinker status: Previous	4.2	4.7	11.7	-3.4	0.0	0.9	-2.6	-1.6	2.5
Pack years of smoking	0.3	0.5	0.9	0.5	-0.5	-0.9	0.1	0.7	-0.9
Impedance of whole body	0.3	1.5	4.1	1.5	-1.2	-1.0	-0.1	0.5	-2.0
Leg fat mass (left)	1.1	4.3	6.8	2.6	0.9	-0.7	2.2	2.5	-2.6
Arm predicted mass (left)	1.0	5.0	12.3	2.7	2.6	1.0	3.5	1.6	-0.6