Best TWAS P=1.59e-23 · Best GWAS P=1.82e-18 conditioned to 0.0608
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -8.7 | 8.9 | 6.5e-19 | -0.96 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | STMN3 | 0.07 | 0.02 | lasso | 4 | 0.05 | 2.8e-06 | -8.0 | -7.5 | 7.6e-14 | 0.71 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | STMN3 | 0.39 | 0.08 | lasso | 5 | 0.22 | 2.1e-06 | -7.8 | -10.0 | 1.6e-23 | 0.65 | 0.09 | 0.78 | TRUE |
| 4 | GTEx | Brain Cerebellum | STMN3 | 0.33 | 0.12 | lasso | 10 | 0.20 | 1.8e-06 | -7.6 | -8.8 | 1.3e-18 | 0.66 | 0.04 | 0.95 | FALSE |
| 5 | GTEx | Brain Cortex | STMN3 | 0.25 | 0.09 | lasso | 7 | 0.11 | 6.8e-04 | -7.8 | -8.7 | 2.7e-18 | 0.73 | 0.09 | 0.69 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | GMEB2 | 0.36 | 0.06 | lasso | 4 | 0.05 | 1.2e-02 | -8.0 | -7.2 | 4.3e-13 | 0.61 | 0.15 | 0.12 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | CTD-3184A7.4 | 0.09 | 0.00 | enet | 28 | 0.00 | 1.4e-01 | -5.8 | -7.2 | 4.4e-13 | 0.49 | 0.02 | 0.84 | FALSE |
| 8 | GTEx | Esophagus Muscularis | GMEB2 | 0.11 | 0.02 | enet | 30 | 0.00 | 4.5e-01 | -8.0 | -5.6 | 1.9e-08 | 0.36 | 0.08 | 0.43 | FALSE |
| 9 | GTEx | Pituitary | STMN3 | 0.43 | 0.00 | enet | 8 | 0.06 | 1.1e-02 | -2.4 | -7.2 | 5.4e-13 | 0.55 | 0.05 | 0.33 | FALSE |
| 10 | GTEx | Testis | RTEL1 | 0.19 | 0.06 | lasso | 5 | 0.14 | 8.0e-07 | -7.8 | -8.8 | 1.1e-18 | 0.62 | 0.15 | 0.68 | TRUE |
| 11 | GTEx | Thyroid | SLC2A4RG | 0.12 | 0.06 | lasso | 5 | 0.04 | 2.4e-04 | -7.8 | 7.4 | 1.2e-13 | -0.74 | 0.21 | 0.73 | FALSE |
| 12 | GTEx | Whole Blood | STMN3 | 0.10 | 0.00 | lasso | 3 | 0.00 | 1.2e-01 | -8.5 | 8.3 | 1.3e-16 | -0.73 | 0.02 | 0.80 | FALSE |
| 13 | METSIM | Adipose | DNAJC5 | 0.03 | 0.00 | blup | 201 | 0.01 | 2.0e-02 | -4.1 | -6.3 | 3.6e-10 | 0.60 | 0.08 | 0.42 | FALSE |
| 14 | METSIM | Adipose | RTEL1 | 0.07 | 0.01 | enet | 15 | 0.03 | 9.2e-06 | -8.5 | 6.4 | 1.9e-10 | -0.44 | 0.05 | 0.94 | FALSE |
| 15 | METSIM | Adipose | STMN3 | 0.20 | 0.08 | enet | 30 | 0.11 | 1.0e-16 | -6.7 | 7.5 | 4.3e-14 | -0.43 | 0.82 | 0.18 | FALSE |
| 16 | METSIM | Adipose | TPD52L2 | 0.03 | 0.00 | bslmm | 207 | 0.02 | 1.5e-03 | 2.1 | 5.9 | 4.5e-09 | -0.68 | 0.02 | 0.74 | FALSE |
| 17 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | -8.5 | -8.8 | 1.3e-18 | 0.98 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STMN3 | 0.02 | 0.02 | blup | 43 | 0.02 | 1.7e-03 | -7.9 | -7.0 | 2.0e-12 | 0.63 | 0.05 | 0.53 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TNFRSF6B | 0.03 | 0.01 | blup | 44 | 0.02 | 7.1e-04 | -7.7 | -7.2 | 5.1e-13 | 0.75 | 0.05 | 0.82 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC2A4RG | 0.03 | 0.01 | blup | 48 | 0.02 | 2.4e-03 | -7.7 | 6.6 | 5.1e-11 | -0.69 | 0.06 | 0.50 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LIME1 | 0.08 | 0.07 | lasso | 4 | 0.06 | 2.0e-04 | -4.1 | 5.6 | 2.7e-08 | -0.61 | 0.13 | 0.56 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -7.8 | -7.8 | 5.0e-15 | 0.84 | 0.04 | 0.48 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.05 | 7.2e-07 | -7.6 | 5.9 | 3.3e-09 | -0.43 | 0.80 | 0.12 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -7.7 | -8.7 | 2.3e-18 | 0.93 | 0.02 | 0.89 | FALSE |
| 25 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | -6.6 | -9.4 | 8.1e-21 | 0.88 | 0.01 | 0.80 | FALSE |
| 26 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | STMN3 | 0.07 | 0.01 | blup | 41 | 0.05 | 4.2e-04 | -7.8 | -5.5 | 3.9e-08 | 0.57 | 0.07 | 0.54 | FALSE |
| 27 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNFRSF6B | 0.05 | 0.02 | blup | 44 | 0.03 | 2.9e-03 | -8.8 | -8.4 | 5.0e-17 | 0.93 | 0.01 | 0.74 | FALSE |
| 28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -8.7 | 8.7 | 3.4e-18 | -0.98 | 0.01 | 0.97 | FALSE |
| 29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -8.6 | -7.8 | 5.2e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC2A4RG | 0.05 | 0.01 | blup | 48 | 0.02 | 2.0e-03 | -8.7 | 7.5 | 6.6e-14 | -0.85 | 0.01 | 0.95 | FALSE |
| 31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | -8.0 | 8.5 | 2.7e-17 | -0.83 | 0.06 | 0.94 | FALSE |
| 32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIME1 | 0.10 | 0.02 | blup | 47 | 0.04 | 1.5e-02 | -8.7 | -7.7 | 1.0e-14 | 0.90 | 0.01 | 0.64 | FALSE |
| 33 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFRP1 | 0.04 | 0.00 | blup | 51 | 0.00 | 1.3e-01 | -8.5 | 7.2 | 6.7e-13 | -0.81 | 0.01 | 0.56 | FALSE |
| 34 | The Cancer Genome Atlas | Thyroid Carcinoma | LIME1 | 0.05 | 0.03 | blup | 47 | 0.04 | 3.9e-05 | -7.6 | -7.8 | 9.4e-15 | 0.81 | 0.05 | 0.94 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.03 | 2.3e-04 | -7.6 | 5.6 | 2.1e-08 | -0.50 | 0.71 | 0.17 | FALSE |