[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr5:138,753,725-141,294,691

Best TWAS P=3e-15 · Best GWAS P=7.92e-12 conditioned to 0.00129

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NDUFA2 0.02 0.01 bslmm 343 0.01 7.8e-03 -5.4 7.1 1.6e-12 -0.36 0.20 0.26 FALSE
2 CommonMind Brain Pre-frontal Cortex PCDHA7 0.13 0.14 lasso 8 0.14 5.1e-17 -5.4 -5.8 5.5e-09 0.27 0.30 0.70 FALSE
3 CommonMind Brain Pre-frontal Cortex PCDHAC1 0.04 0.00 bslmm 442 0.01 6.4e-03 4.1 -6.0 2.2e-09 0.10 0.05 0.72 FALSE
4 CommonMind Brain Pre-frontal Cortex ZMAT2 0.06 0.10 blup 360 0.09 1.4e-11 -6.2 -6.1 1.4e-09 0.37 0.18 0.82 FALSE
5 GTEx Adipose Subcutaneous PFDN1 0.20 0.19 lasso 4 0.18 6.3e-15 -5.9 5.9 3.5e-09 -0.57 0.66 0.34 FALSE
6 GTEx Adipose Subcutaneous IK 0.16 0.07 lasso 5 0.07 2.7e-06 -6.3 -5.6 1.8e-08 0.20 0.25 0.75 FALSE
7 GTEx Adipose Visceral Omentum PFDN1 0.13 0.10 lasso 9 0.08 3.9e-05 -5.8 5.5 3.8e-08 -0.51 0.64 0.34 FALSE
8 GTEx Adipose Visceral Omentum TMCO6 0.06 0.01 enet 7 0.03 1.3e-02 -4.3 -6.0 2.5e-09 0.27 0.30 0.18 FALSE
9 GTEx Artery Aorta PFDN1 0.20 0.15 lasso 2 0.17 1.3e-09 -5.8 6.4 1.2e-10 -0.57 0.66 0.34 FALSE
10 GTEx Artery Coronary PFDN1 0.15 0.06 enet 11 0.04 1.9e-02 -5.8 6.7 2.2e-11 -0.74 0.06 0.68 FALSE
11 GTEx Artery Tibial PFDN1 0.19 0.19 enet 12 0.22 9.8e-17 -5.9 5.9 3.6e-09 -0.57 0.65 0.35 FALSE
12 GTEx Artery Tibial TMCO6 0.04 0.04 enet 5 0.04 4.1e-04 4.1 -5.3 1.1e-07 0.22 0.51 0.42 FALSE
13 GTEx Artery Tibial IK 0.06 0.04 enet 13 0.05 1.3e-04 -5.8 -6.3 2.8e-10 0.22 0.38 0.59 FALSE
14 GTEx Artery Tibial CYSTM1 0.19 0.17 lasso 9 0.14 2.8e-11 -5.8 6.1 1.2e-09 -0.58 0.70 0.30 FALSE
15 GTEx Artery Tibial SRA1 0.07 0.02 lasso 10 0.02 7.8e-03 -4.6 -6.6 4.2e-11 0.42 0.14 0.43 FALSE
16 GTEx Brain Caudate basal ganglia CYSTM1 0.22 0.15 lasso 11 0.12 3.4e-04 -5.9 5.3 1.0e-07 -0.53 0.14 0.31 FALSE
17 GTEx Brain Cerebellum TMCO6 0.23 0.18 enet 14 0.22 3.3e-07 -4.4 -5.8 5.0e-09 0.22 0.63 0.35 FALSE
18 GTEx Brain Cerebellum WDR55 0.10 0.00 enet 11 0.02 1.0e-01 -5.8 -5.4 7.0e-08 0.23 0.21 0.30 FALSE
19 GTEx Brain Cerebellum HARS 0.11 0.17 enet 19 0.12 1.6e-04 -6.2 6.4 1.6e-10 -0.24 0.20 0.69 FALSE
20 GTEx Brain Cortex CYSTM1 0.20 0.01 lasso 10 0.00 3.1e-01 -5.9 5.9 4.4e-09 -0.55 0.06 0.08 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia PFDN1 0.16 0.01 lasso 5 0.03 5.6e-02 5.8 7.0 2.0e-12 -0.81 0.04 0.57 FALSE
22 GTEx Brain Nucleus accumbens basal ganglia CYSTM1 0.22 0.08 lasso 8 0.06 8.5e-03 -5.6 5.7 1.2e-08 -0.53 0.06 0.37 FALSE
23 GTEx Brain Putamen basal ganglia LINC01024 0.22 0.03 lasso 6 0.04 3.6e-02 -5.9 5.2 1.6e-07 -0.50 0.08 0.14 FALSE
24 GTEx Breast Mammary Tissue PFDN1 0.17 0.20 lasso 5 0.19 4.1e-10 -5.9 6.4 1.2e-10 -0.71 0.53 0.47 FALSE
25 GTEx Breast Mammary Tissue TMCO6 0.08 0.05 lasso 4 0.08 1.0e-04 -6.3 -6.5 6.6e-11 0.24 0.18 0.70 FALSE
26 GTEx Breast Mammary Tissue IK 0.07 0.06 lasso 8 0.06 3.5e-04 -6.1 -6.3 3.6e-10 0.23 0.23 0.73 FALSE
27 GTEx Breast Mammary Tissue (Male) PFDN1 0.24 0.04 lasso 9 0.09 4.0e-03 -5.0 7.2 4.6e-13 -0.54 0.07 0.66 FALSE
28 GTEx Breast Mammary Tissue (Male) TMCO6 0.12 -0.01 lasso 2 -0.01 4.9e-01 -4.3 -5.4 7.0e-08 0.31 0.05 0.08 FALSE
29 GTEx Cells EBV-transformed lymphocytes PFDN1 0.20 0.02 lasso 3 0.03 4.4e-02 -5.9 5.7 9.1e-09 -0.62 0.12 0.27 FALSE
30 GTEx Cells EBV-transformed lymphocytes SRA1 0.33 0.21 lasso 9 0.19 6.3e-07 4.4 -5.6 2.1e-08 0.35 0.52 0.27 FALSE
31 GTEx Cells Transformed fibroblasts HARS2 0.04 0.01 enet 15 0.02 1.1e-02 5.0 -5.7 1.4e-08 0.37 0.20 0.55 FALSE
32 GTEx Cells Transformed fibroblasts PFDN1 0.31 0.39 enet 16 0.42 1.5e-33 -5.8 5.9 3.6e-09 -0.57 0.66 0.34 FALSE
33 GTEx Cells Transformed fibroblasts TMCO6 0.11 0.11 lasso 6 0.11 1.8e-08 -5.1 -6.3 3.3e-10 0.25 0.74 0.26 FALSE
34 GTEx Cells Transformed fibroblasts IK 0.07 0.04 lasso 4 0.02 1.0e-02 -5.7 -6.2 7.0e-10 0.26 0.30 0.64 FALSE
35 GTEx Cells Transformed fibroblasts WDR55 0.05 0.08 lasso 13 0.07 4.0e-06 -6.1 -6.2 4.6e-10 0.24 0.23 0.77 FALSE
36 GTEx Cells Transformed fibroblasts ZMAT2 0.04 0.02 lasso 4 0.02 2.4e-02 -5.7 -5.9 4.0e-09 0.25 0.30 0.34 FALSE
37 GTEx Cells Transformed fibroblasts SRA1 0.27 0.22 lasso 7 0.29 2.8e-22 4.4 -5.6 2.0e-08 0.25 0.94 0.06 FALSE
38 GTEx Colon Sigmoid PFDN1 0.33 0.32 lasso 12 0.28 2.1e-10 -5.9 6.7 2.9e-11 -0.57 0.46 0.54 FALSE
39 GTEx Colon Transverse TMCO6 0.15 0.06 enet 16 0.05 1.4e-03 4.1 -5.9 3.2e-09 0.40 0.25 0.32 FALSE
40 GTEx Esophagus Gastroesophageal Junction PFDN1 0.24 0.09 enet 20 0.12 3.3e-05 -5.9 7.3 4.1e-13 -0.49 0.31 0.30 FALSE
41 GTEx Esophagus Mucosa TMCO6 0.04 0.02 lasso 4 0.01 6.1e-02 -4.5 -6.2 4.6e-10 0.32 0.22 0.32 FALSE
42 GTEx Esophagus Mucosa ZMAT2 0.06 0.02 enet 16 0.02 1.1e-02 4.7 -6.0 1.5e-09 0.31 0.35 0.21 FALSE
43 GTEx Esophagus Muscularis PFDN1 0.25 0.26 lasso 4 0.27 1.3e-16 -5.6 5.8 6.6e-09 -0.56 0.68 0.32 FALSE
44 GTEx Esophagus Muscularis CYSTM1 0.09 0.08 lasso 1 0.08 1.2e-05 -5.6 5.6 1.6e-08 -0.56 0.43 0.44 FALSE
45 GTEx Esophagus Muscularis WDR55 0.05 0.01 lasso 4 0.03 6.6e-03 -5.4 -6.1 7.9e-10 0.22 0.20 0.33 FALSE
46 GTEx Heart Atrial Appendage PFDN1 0.12 0.14 lasso 6 0.12 4.3e-06 -5.8 5.8 5.3e-09 -0.57 0.57 0.39 FALSE
47 GTEx Heart Left Ventricle PFDN1 0.31 0.33 enet 17 0.33 4.2e-18 -5.8 6.4 1.9e-10 -0.58 0.64 0.36 FALSE
48 GTEx Heart Left Ventricle TMCO6 0.05 0.01 lasso 5 0.00 6.2e-01 -5.7 -5.4 7.1e-08 0.22 0.23 0.09 FALSE
49 GTEx Heart Left Ventricle PCDHB5 0.11 0.05 lasso 3 0.06 5.3e-04 3.7 5.7 1.3e-08 -0.16 0.16 0.45 FALSE
50 GTEx Lung TMCO6 0.06 0.03 lasso 3 0.03 1.1e-03 -4.4 -5.9 3.8e-09 0.23 0.52 0.36 FALSE
51 GTEx Muscle Skeletal PFDN1 0.45 0.56 enet 22 0.56 6.5e-66 -6.0 6.0 1.6e-09 -0.56 0.63 0.37 FALSE
52 GTEx Nerve Tibial TMCO6 0.22 0.20 enet 12 0.20 2.7e-14 -4.4 -5.8 6.5e-09 0.21 0.98 0.02 FALSE
53 GTEx Nerve Tibial IK 0.08 0.08 lasso 8 0.06 8.3e-05 -6.0 -5.9 2.8e-09 0.22 0.24 0.75 FALSE
54 GTEx Nerve Tibial CYSTM1 0.20 0.20 lasso 3 0.20 5.5e-14 -5.8 5.8 6.1e-09 -0.57 0.74 0.26 FALSE
55 GTEx Nerve Tibial WDR55 0.05 0.01 enet 8 0.04 7.5e-04 -2.5 -6.0 1.6e-09 0.67 0.14 0.58 FALSE
56 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -5.7 6.0 2.1e-09 -0.27 0.27 0.56 FALSE
57 GTEx Skin Not Sun Exposed Suprapubic PFDN1 0.10 0.10 lasso 3 0.10 5.3e-06 -5.6 5.8 4.9e-09 -0.55 0.59 0.30 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic IK 0.08 0.05 lasso 14 0.04 3.0e-03 -6.4 -5.6 2.3e-08 0.20 0.24 0.59 FALSE
59 GTEx Skin Not Sun Exposed Suprapubic ZMAT2 0.16 0.01 enet 19 0.04 1.7e-03 -6.1 -6.2 5.6e-10 0.32 0.12 0.14 FALSE
60 GTEx Skin Sun Exposed Lower leg PFDN1 0.16 0.12 enet 12 0.11 3.9e-09 -5.8 5.7 1.1e-08 -0.42 0.69 0.31 FALSE
61 GTEx Skin Sun Exposed Lower leg WDR55 0.04 0.01 enet 10 0.01 2.8e-02 -6.3 -6.9 4.7e-12 0.34 0.15 0.69 FALSE
62 GTEx Skin Sun Exposed Lower leg ZMAT2 0.12 0.12 enet 22 0.15 1.7e-12 -5.7 -6.3 3.6e-10 0.36 0.19 0.81 FALSE
63 GTEx Skin Sun Exposed Lower leg SRA1 0.05 0.04 lasso 3 0.06 1.0e-05 -4.2 -5.8 5.7e-09 0.27 0.47 0.38 FALSE
64 GTEx Spleen PFDN1 0.26 0.02 lasso 5 0.12 6.0e-04 5.8 5.9 3.9e-09 -0.69 0.03 0.58 FALSE
65 GTEx Testis PFDN1 0.15 0.00 lasso 8 0.00 4.9e-01 -5.8 5.5 3.1e-08 -0.57 0.07 0.10 FALSE
66 GTEx Testis ZMAT2 0.09 0.12 lasso 1 0.10 2.1e-05 -6.4 -6.4 2.1e-10 0.22 0.15 0.84 FALSE
67 GTEx Testis SRA1 0.16 0.02 lasso 7 0.06 1.6e-03 -4.4 -5.4 7.2e-08 0.33 0.25 0.16 FALSE
68 GTEx Thyroid PFDN1 0.10 0.07 lasso 4 0.05 1.5e-04 -5.8 5.9 4.5e-09 -0.57 0.63 0.36 FALSE
69 GTEx Thyroid TMCO6 0.22 0.22 lasso 6 0.22 1.6e-16 -4.3 -5.1 3.1e-07 0.19 1.00 0.00 FALSE
70 GTEx Thyroid CYSTM1 0.07 0.05 lasso 5 0.03 3.2e-03 -5.6 5.4 7.3e-08 -0.50 0.61 0.24 FALSE
71 GTEx Vagina IK 0.27 0.09 enet 29 0.15 2.4e-04 -4.3 -6.2 5.2e-10 0.21 0.35 0.47 FALSE
72 METSIM Adipose CYSTM1 0.05 0.01 bslmm 333 0.02 1.4e-04 -5.9 5.5 3.4e-08 -0.38 0.22 0.17 FALSE
73 METSIM Adipose DND1 0.08 0.11 lasso 5 0.10 7.3e-15 -5.8 5.6 2.3e-08 -0.25 0.36 0.64 FALSE
74 METSIM Adipose PFDN1 0.19 0.20 enet 32 0.20 4.1e-29 -5.9 5.7 1.1e-08 -0.57 0.65 0.35 FALSE
75 METSIM Adipose TMCO6 0.10 0.08 lasso 8 0.11 7.0e-16 -4.4 -5.3 1.0e-07 0.19 1.00 0.00 FALSE
76 ROSMAP Brain Pre-frontal Cortex PFDN1 0.05 0.05 lasso 1 0.04 2.1e-06 -5.9 5.9 4.8e-09 -0.55 0.68 0.31 FALSE
77 ROSMAP Brain Pre-frontal Cortex CYSTM1 0.21 0.25 bslmm 322 0.26 1.0e-33 -5.9 5.6 2.3e-08 -0.49 0.64 0.36 FALSE
78 ROSMAP Brain Pre-frontal Cortex NDUFA2 0.09 0.12 enet 22 0.12 1.3e-15 -6.3 6.0 1.6e-09 -0.29 0.15 0.85 FALSE
79 ROSMAP Brain Pre-frontal Cortex ZMAT2 0.03 0.02 bslmm 185 0.02 6.5e-04 -6.2 -7.9 3.0e-15 0.52 0.16 0.81 TRUE
80 ROSMAP Brain Pre-frontal Cortex HARS 0.02 0.00 enet 4 0.01 2.1e-02 4.4 5.6 2.1e-08 -0.27 0.05 0.14 FALSE
81 ROSMAP Brain Pre-frontal Cortex PCDHB13 0.03 0.02 lasso 3 0.02 7.1e-04 -6.1 5.8 5.6e-09 -0.25 0.01 0.92 FALSE
82 ROSMAP Brain Pre-frontal Cortex PCDHA8 0.04 0.03 enet 4 0.03 3.4e-05 -6.1 -5.8 7.1e-09 0.24 0.04 0.96 FALSE
83 YFS Blood APBB3 0.01 0.00 bslmm 318 0.00 2.7e-02 -4.3 6.3 3.5e-10 -0.34 0.20 0.06 FALSE
84 YFS Blood HBEGF 0.02 0.02 lasso 3 0.02 9.8e-07 5.8 5.4 5.2e-08 -0.82 0.19 0.81 FALSE
85 YFS Blood NDUFA2 0.08 0.11 lasso 6 0.11 2.0e-33 -6.3 6.2 4.7e-10 -0.20 0.21 0.79 FALSE
86 YFS Blood TMCO6 0.01 0.00 blup 329 0.01 4.1e-03 -6.1 -5.8 7.9e-09 0.33 0.31 0.63 FALSE
87 YFS Blood WDR55 0.15 0.21 bslmm 337 0.21 8.6e-67 -6.2 -6.2 4.9e-10 0.25 0.18 0.82 FALSE
88 YFS Blood ZMAT2 0.04 0.04 enet 12 0.04 1.4e-13 -5.1 -5.9 3.4e-09 0.22 0.99 0.01 FALSE
89 The Cancer Genome Atlas Bladder Urothelial Carcinoma NDUFA2 0.07 0.04 blup 41 0.03 1.8e-03 -6.3 6.4 1.4e-10 -0.22 0.02 0.97 FALSE
90 The Cancer Genome Atlas Breast Invasive Carcinoma PCDHA4 0.01 0.02 lasso 1 0.01 4.9e-04 -5.7 -5.7 1.5e-08 0.25 0.00 0.97 FALSE
91 The Cancer Genome Atlas Breast Invasive Carcinoma PFDN1 0.02 0.01 enet 4 0.02 7.8e-05 -6.0 6.0 1.7e-09 -0.55 0.41 0.42 FALSE
92 The Cancer Genome Atlas Breast Invasive Carcinoma WDR55 0.10 0.03 enet 8 0.04 3.3e-09 -6.3 -6.5 8.8e-11 0.24 0.02 0.98 FALSE
93 The Cancer Genome Atlas Breast Invasive Carcinoma ZMAT2 0.03 0.03 enet 5 0.03 7.7e-07 4.6 -5.7 1.3e-08 0.22 0.05 0.94 FALSE
94 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma WDR55 0.04 0.04 blup 44 0.03 8.2e-03 -6.3 -6.1 1.1e-09 0.23 0.02 0.78 FALSE
95 The Cancer Genome Atlas Colon Adenocarcinoma WDR55 0.09 0.08 enet 12 0.12 1.5e-07 -6.2 -5.2 2.6e-07 0.20 0.02 0.98 FALSE
96 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NDUFA2 0.04 0.07 lasso 1 0.06 1.5e-07 -6.2 6.2 4.4e-10 -0.24 0.02 0.98 FALSE
97 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCDHA4 0.03 0.01 blup 31 0.01 3.3e-02 -5.7 -5.2 1.7e-07 0.24 0.00 0.82 FALSE
98 The Cancer Genome Atlas Brain Lower Grade Glioma C5orf32 0.03 0.04 lasso 2 0.04 3.1e-05 -5.9 6.1 1.3e-09 -0.58 0.46 0.46 FALSE
99 The Cancer Genome Atlas Brain Lower Grade Glioma PFDN1 0.05 0.01 blup 47 0.01 1.9e-02 -6.2 6.9 6.5e-12 -0.66 0.02 0.73 FALSE
100 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PFDN1 0.07 0.05 lasso 2 0.05 2.0e-03 -5.8 5.8 5.2e-09 -0.57 0.18 0.22 FALSE
101 The Cancer Genome Atlas Lung Adenocarcinoma NDUFA2 0.07 0.04 enet 4 0.04 3.6e-05 -6.3 5.6 1.8e-08 -0.22 0.01 0.97 FALSE
102 The Cancer Genome Atlas Lung Adenocarcinoma PFDN1 0.03 0.02 blup 47 0.02 5.5e-03 -6.7 6.9 5.4e-12 -0.92 0.01 0.89 FALSE
103 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PFDN1 0.04 0.02 lasso 3 0.03 2.0e-04 -5.9 6.0 1.6e-09 -0.64 0.29 0.37 FALSE
104 The Cancer Genome Atlas Lung Squamous Cell Carcinoma WDR55 0.02 0.02 lasso 2 0.02 2.3e-03 -6.0 -6.0 1.5e-09 0.23 0.02 0.92 FALSE
105 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma NDUFA2 0.03 0.02 blup 42 0.04 1.1e-03 4.1 5.4 7.6e-08 -0.22 0.02 0.78 FALSE
106 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma WDR55 0.11 0.09 lasso 6 0.07 1.4e-05 -6.3 -6.3 2.5e-10 0.25 0.02 0.98 FALSE
107 The Cancer Genome Atlas Pancreatic Adenocarcinoma NDUFA2 0.10 0.04 blup 43 0.06 1.4e-03 -6.2 6.4 2.1e-10 -0.24 0.02 0.93 FALSE
108 The Cancer Genome Atlas Prostate Adenocarcinoma HBEGF 0.03 0.03 lasso 3 0.02 2.2e-03 -6.7 6.8 1.0e-11 -0.79 0.00 0.98 FALSE
109 The Cancer Genome Atlas Prostate Adenocarcinoma NDUFA2 0.03 0.02 blup 41 0.03 4.6e-04 -6.3 6.3 2.2e-10 -0.22 0.02 0.90 FALSE
110 The Cancer Genome Atlas Prostate Adenocarcinoma PFDN1 0.06 0.07 lasso 5 0.06 3.2e-07 -5.9 5.9 3.4e-09 -0.58 0.51 0.49 FALSE
111 The Cancer Genome Atlas Prostate Adenocarcinoma WDR55 0.07 0.06 blup 44 0.06 1.7e-06 -6.3 -5.8 7.1e-09 0.23 0.02 0.98 FALSE
112 The Cancer Genome Atlas Prostate Adenocarcinoma ZMAT2 0.03 0.03 enet 6 0.04 1.3e-04 -6.2 -5.9 3.7e-09 0.24 0.02 0.91 FALSE
113 The Cancer Genome Atlas Soft Tissue Sarcoma WDR55 0.07 0.08 lasso 5 0.08 1.8e-05 -6.3 -5.8 5.8e-09 0.23 0.02 0.96 FALSE
114 The Cancer Genome Atlas Stomach Adenocarcinoma WDR55 0.04 0.01 blup 45 0.03 3.7e-03 4.8 -5.3 1.5e-07 0.20 0.02 0.72 FALSE
115 The Cancer Genome Atlas Thyroid Carcinoma NDUFA2 0.03 0.01 blup 41 0.03 8.3e-04 -6.3 6.5 7.1e-11 -0.23 0.02 0.89 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma SLC4A9 0.07 0.02 blup 30 0.06 3.1e-06 4.5 -5.9 4.3e-09 0.45 0.40 0.13 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma WDR55 0.25 0.12 lasso 5 0.12 7.0e-12 -6.0 -5.6 1.9e-08 0.21 0.03 0.97 FALSE
118 The Cancer Genome Atlas Thyroid Carcinoma ZMAT2 0.03 0.02 blup 38 0.03 9.6e-04 -6.2 -6.3 4.0e-10 0.23 0.02 0.94 FALSE