Hub : Genes

PCDHAC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.039 0.0200 2.5e-03 -0.002 0.014 -0.001 0.014 -0.002 7.3e-01 6.9e-03 4.4e-01 6.4e-03 6.1e-01
2 ROSMAP Brain Pre-frontal Cortex 0.134 0.0369 4.6e-12 0.130 0.104 0.115 0.121 0.129 2.5e-16 2.8e-13 1.3e-14 2.6e-15 3.3e-16

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.3 2.0 3.4 0.7 1.9
Bipolar Disorder or Schizophrenia 5.9 14.5 15.0 3.7 3.9
Depressed Affect (Nagel 2018) 4.5 9.5 18.3 -4.3 -0.8
Depression (Nagel 2018) 7.4 11.1 17.8 -4.2 -2.1
Intelligence (Savage-Jansen 2018) 8.0 24.5 35.8 -6.0 -3.6
Neuroticism (Nagel 2018) 1.4 3.2 6.3 -2.5 -0.5
Schizophrenia (2018) 7.2 15.0 17.8 4.2 3.5
Schizophrenia vs Biploar Disorder 1.1 1.4 2.8 1.7 -0.2
Worry (Nagel 2018) 0.1 0.1 0.2 -0.4 0.3
Alzheimer’s Disease (in mother) 1.3 1.5 2.9 0.4 1.7
Alzheimer’s Disease (in father) 0.0 0.0 0.0 0.2 -0.2
Alzheimer’s Disease (including proxy) 2.2 3.2 3.4 1.9 1.8
Crohns Disease (2017) 1.2 2.6 4.9 -0.5 -2.2
Irritable Bowel Disease (IBD) 0.5 1.1 2.2 0.1 -1.5
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.3 -0.5
Major Depression (MDD) 2.7 3.2 4.0 -2.0 -1.6
Reaction Time 0.8 1.5 3.0 0.2 -1.7
Verbal and Numeric Reasoning (VNR) 4.1 9.9 13.0 -3.6 -2.6
Breast Cancer 0.4 1.0 2.0 -1.4 -0.0
Ovarian Cancer 0.2 0.2 0.4 0.1 -0.6
Prostate Cancer 0.7 1.0 1.2 1.1 -0.9
Age at First Birth 0.4 0.5 0.7 -0.6 0.9
Bipolar Disorder (2011) 2.3 2.3 3.1 1.8 1.2
Body Mass Index (BMI) (2010) 0.3 0.4 0.6 -0.3 0.8
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.1 0.4
Crohns Disease (2012) 0.0 0.0 0.0 0.0 0.1
Mean Putamen Volume 1.2 1.4 2.5 -0.6 -1.6
Fasting Glucose 2.6 3.1 3.3 1.8 1.7
HbA1C 0.2 0.2 0.5 -0.1 0.7
HDL Cholesterol 0.0 0.1 0.1 0.1 -0.4
LDL Cholesterol 0.7 1.1 2.2 1.5 0.1
Lupus 1.0 1.6 3.1 -1.8 0.0
Neuroticism (2016) 1.0 1.5 2.2 -1.5 -0.9
Primary Biliary Cirrhosis 1.0 1.5 2.9 0.1 -1.7
Rheumatoid Arthritis 0.6 0.9 1.7 -0.2 -1.3
Schizophrenia (2014) 3.5 7.7 10.6 3.3 2.2
Triglycerides 0.7 1.2 2.2 -0.3 1.5
Type 2 Diabetes (T2D) (2012) 0.6 0.7 0.8 -0.9 -0.8
Ulcerative Colitis 0.1 0.2 0.4 0.6 -0.1
Blood Eosinophil Count 0.2 1.2 1.9 -1.4 0.7
Blood Platelet Count 0.2 2.6 4.3 2.1 1.0
Blood Red Count 0.2 2.3 4.5 0.3 2.1
Blood White Count 1.1 8.3 11.2 3.4 2.3
Heel T-Score 0.2 1.2 1.4 1.2 1.1
BMI 0.8 4.6 6.0 -2.4 -1.8
Height 0.4 7.5 9.9 -2.3 -3.2
Waist Hip Ratio (WHR) 1.0 4.5 8.5 2.9 0.7
Systolic Blood Pressure 5.0 25.2 46.1 6.8 2.0
Smoking Status 0.6 1.4 2.6 -0.6 -1.6
Allergy or Eczema 2.7 7.2 12.4 -3.5 -1.4
Cardiovascular Disease 0.0 0.1 0.1 -0.2 -0.3
Hypothyroidism (self reported) 0.3 0.6 0.7 0.7 -0.8
Respiratory disease 5.0 11.2 19.4 -4.4 -1.7
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.3 -0.2 -1.5
Lung FEV1/FVC ratio 1.7 8.7 12.2 2.2 -3.5
Lung FVC 2.3 11.7 18.4 -2.2 -4.3
Neuroticism 2.2 5.4 9.6 -3.1 -1.1
Chronotype (morning person) 1.0 2.3 4.4 -0.5 -2.1
Hair Pigment 0.1 1.4 2.6 -0.6 1.6
Tanning 0.1 0.8 1.4 1.2 -0.4
Hand grip strength (left) 0.0 0.1 0.1 0.2 0.4
Number of treatments/medications taken 0.8 1.5 3.0 -1.7 0.0
Average weekly spirits intake 1.4 1.7 3.4 -0.1 -1.9
Sensitivity / hurt feelings 0.3 0.5 1.0 -1.0 0.1
Frequency of depressed mood in last 2 weeks 5.0 7.0 12.3 -3.5 -1.3
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.5 -0.3
Relative age of first facial hair 0.2 0.4 0.6 -0.5 -0.8
Other serious medical condition/disability diagnosed by doctor 4.8 6.2 9.1 -3.0 -1.8
Ever used hormone-replacement therapy (HRT) 2.3 2.9 4.4 -2.1 -1.2
Ever had hysterectomy (womb removed) 3.0 3.4 5.0 -2.2 -1.4
Systolic blood pressure, automated reading 2.0 5.7 11.0 3.3 0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.8 -0.5 -1.4
Angina 0.2 0.3 0.5 0.1 -0.7
Medication for hormone replacement therapy 1.0 1.1 1.9 -0.5 -1.4
Vitamin and mineral supplements 0.6 0.8 1.5 -1.2 -0.4
Supplements: Zinc 1.3 1.4 2.7 0.2 -1.7
Medication: Co-codamol 1.7 2.0 3.3 0.8 -1.8
Medication: Metformin 0.1 0.1 0.2 0.4 0.0
Diabetes (father) 0.1 0.1 0.2 0.2 -0.4
Diabetes (mother) 0.7 0.9 1.1 -0.9 -1.0
Severe depression (siblings) 0.2 0.2 0.2 -0.3 -0.5
Pack years adult smoking proportion 0.4 0.6 0.7 0.7 -0.8
Impedance of leg (right) 0.0 0.2 0.4 0.6 0.1
Leg fat-free mass (left) 0.8 4.3 6.0 -1.6 -2.5
Trunk fat percentage 1.7 6.9 9.5 -2.1 -3.1
Hand grip strength (right) 0.0 0.1 0.1 0.3 -0.1
Townsend deprivation index at recruitment 0.7 1.0 1.8 -1.4 0.5
Current tobacco smoking 1.8 2.9 5.8 -0.2 -2.4
Average weekly fortified wine intake 0.3 0.4 0.4 -0.6 -0.6
Maternal smoking around birth 0.1 0.2 0.2 0.3 -0.5
Fed-up feelings 2.9 5.3 10.6 -3.2 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 4.5 6.0 7.8 -2.8 -2.1
Relative age voice broke 0.7 1.1 2.0 -0.2 1.4
Taking other prescription medications 3.0 4.6 6.8 -2.6 -1.5
Age when periods started (menarche) 1.3 3.2 4.6 1.3 2.1
Bilateral oophorectomy (both ovaries removed) 3.3 3.8 5.5 -1.5 -2.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 0.6 0.5
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 1.6 -1.3 -1.3
Qualifications: CSEs or equivalent 0.2 0.3 0.3 -0.5 -0.5
Serious illness, injury or assault to yourself 0.5 0.5 1.0 -0.4 -1.0
High blood pressure 0.3 0.9 1.7 1.3 -0.1
Hayfever, allergic rhinitis or eczema 1.9 4.2 8.3 -2.9 -0.4
Multivitamins +/- minerals 0.7 0.9 1.3 1.1 0.7
Stomach or abdominal pain in last month 0.6 0.7 1.1 -0.6 1.1
Supplements: Glucosamine 2.8 3.7 4.2 2.0 1.8
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 2.8 -1.7 -0.8
Medication: Atenolol 0.8 1.0 2.0 1.4 -0.1
Medication: Levothyroxine sodium 0.5 0.9 1.7 0.4 -1.3
Sitting height 1.4 10.2 14.0 -3.7 -2.5
Chronic bronchitis/emphysema (father) 0.6 0.7 0.8 -0.7 -0.9
High blood pressure (mother) 1.2 1.7 2.7 -1.6 -0.9
Body mass index (BMI) 0.6 2.7 4.2 -1.1 -2.1
Impedance of leg (left) 0.0 0.2 0.3 0.6 -0.3
Leg predicted mass (left) 0.8 4.3 6.0 -1.6 -2.5
Trunk fat mass 1.7 7.5 10.2 -2.2 -3.2
Waist circumference 0.8 2.8 5.4 -0.4 -2.3
Number of incorrect matches in round 0.6 1.0 1.1 1.0 1.0
Past tobacco smoking 0.7 1.2 1.9 1.4 0.7
Alcohol usually taken with meals 0.4 0.6 0.7 0.8 -0.8
Nervous feelings 0.0 0.0 0.0 0.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.8 6.6 -2.6 -1.0
Hearing difficulty/problems with background noise 2.1 3.4 6.3 -2.5 -0.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.2 -0.4
Had menopause 0.0 0.0 0.1 0.2 -0.1
Had other major operations 2.4 2.9 3.1 -1.8 -1.6
Forced vital capacity (FVC) 2.5 9.8 16.0 -1.9 -4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.8 -0.0 0.9
Ever unenthusiastic/disinterested for a whole week 13.9 17.0 25.4 -5.0 -2.9
Qualifications: None of the above 0.7 1.6 3.0 1.7 0.3
Financial difficulties in last 2 years 0.4 0.6 1.0 -1.0 0.3
Mouth/teeth dental problems 0.5 0.8 0.8 -0.9 -0.9
Heart attack 0.8 1.0 1.9 0.4 1.4
Allergy 3.0 6.9 12.4 3.5 1.2
Pain all over the body in last month 0.0 0.0 0.0 0.0 0.1
Diabetes (self-reported) 0.2 0.3 0.7 0.1 -0.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.3 -0.3
Medication: Ramipril 2.3 2.9 4.1 2.0 1.3
Medication: Simvastatin 1.3 1.8 2.1 1.4 1.3
Fluid intelligence score 1.9 4.0 6.7 -2.6 -1.2
Illnesses of siblings 0.7 1.0 1.8 0.4 1.3
Neuroticism score 1.4 3.0 5.9 -2.4 -0.2
Weight 1.4 7.1 10.3 -2.0 -3.2
Impedance of arm (right) 0.0 0.1 0.2 -0.2 0.5
Arm fat percentage (right) 0.9 3.4 5.4 -1.1 -2.3
Trunk fat-free mass 0.8 4.5 6.8 -1.5 -2.6
Hip circumference 1.8 7.6 12.3 -1.7 -3.5
Time employed in main current job 1.1 1.3 1.5 -1.2 -1.0
Alcohol intake versus 10 years previously 1.0 1.4 2.8 0.2 1.7
Father’s age at death 0.9 1.2 2.4 -0.1 -1.5
Worrier / anxious feelings 0.1 0.3 0.5 0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 5.9 9.6 13.2 -3.6 -2.4
Falls in the last year 1.1 1.5 2.8 -1.7 -0.5
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.1 0.5
Number of live births 0.4 0.6 0.9 1.0 0.5
Forced expiratory volume in 1-second (FEV1) 2.8 9.5 18.5 -0.7 -4.3
Pulse rate 1.1 1.8 3.6 -0.1 1.9
Happiness 2.9 3.6 6.5 -2.6 -0.8
Noisy workplace 1.4 1.7 2.3 -1.0 -1.5
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 -1.3 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.6 -1.6 -0.7
Mouth/teeth dental problems: Dentures 0.4 0.6 0.7 -0.8 -0.8
Asthma 2.6 5.1 5.4 -2.3 -2.2
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.6 -1.6 -0.7
Medication: Cholesterol lowering 0.3 0.4 0.8 -0.2 0.9
Depression (self-reported) 0.3 0.3 0.6 -0.2 -0.8
Medication: Lansoprazole 1.9 2.2 3.4 -1.8 -1.0
Prospective memory result 0.8 0.9 1.5 1.2 -0.6
Lung cancer (father) 0.4 0.5 1.0 -0.0 1.0
Illnesses of mother 0.7 0.8 1.5 1.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 4.1 13.2 22.8 -1.9 -4.8
Pulse wave Arterial Stiffness index 0.3 0.3 0.4 -0.6 0.5
Impedance of arm (left) 0.0 0.0 0.0 -0.1 -0.2
Arm fat mass (right) 1.3 5.2 8.5 -1.4 -2.9
Trunk predicted mass 0.8 4.5 7.0 -1.4 -2.6
Standing height 0.7 6.8 9.1 -2.1 -3.0
Length of working week for main job 0.7 0.7 0.8 -0.8 -0.9
Exposure to tobacco smoke at home 0.3 0.4 0.5 0.5 0.7
Breastfed as a baby 0.4 0.5 0.7 0.9 -0.5
Tense / ‘highly strung’ 0.7 1.1 2.2 -1.5 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 3.0 4.7 8.6 -2.9 -0.9
Hair/balding pattern: Pattern 4 1.6 3.9 4.2 1.9 2.0
Birth weight of first child 0.2 0.3 0.6 0.1 -0.8
Peak expiratory flow (PEF) 1.5 3.5 5.3 2.3 -1.3
Pulse wave reflection index 0.2 0.3 0.3 -0.6 -0.5
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.5 -1.6 -0.2
Loud music exposure frequency 1.9 2.0 3.4 -1.8 -0.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.6 -0.0
Mouth/teeth dental problems: Bleeding gums 5.7 7.4 10.5 2.1 3.2
Blood clot in the leg (DVT) 1.6 2.1 2.8 -1.7 -1.2
Medication: Paracetamol 1.0 1.6 2.5 -0.9 1.6
Headache pain in last month 0.2 0.3 0.6 0.7 -0.1
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 4.1 -0.5 -2.0
Glaucoma (self-reported) 1.6 1.9 2.0 -1.4 -1.3
Gout (self-reported) 0.4 0.5 0.6 -0.8 -0.7
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.9 0.0 -1.7
Medication: Amlodipine 1.7 2.3 2.9 1.7 1.3
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.4 0.6 -0.5
Birth weight 2.4 5.3 8.3 -2.9 -1.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.4 -1.2 -0.3
High blood pressure (siblings) 1.1 1.6 3.0 -0.3 -1.7
Forced vital capacity (FVC), Best measure 3.7 13.7 20.9 -2.5 -4.6
Body fat percentage 1.4 5.7 8.2 -1.8 -2.9
Leg fat percentage (right) 1.0 3.6 6.1 -1.0 -2.5
Arm fat-free mass (right) 1.0 5.1 8.2 -1.4 -2.9
Exposure to tobacco smoke outside home 0.1 0.1 0.1 0.3 0.3
Comparative body size at age 10 0.2 0.6 0.9 -0.5 -0.9
Number of full brothers 0.9 1.1 2.2 -1.5 -0.2
Worry too long after embarrassment 0.1 0.2 0.3 0.3 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.1 -1.8 -0.3
Wheeze or whistling in the chest in last year 0.7 1.2 2.1 -1.4 -0.6
Number of children fathered 0.5 0.6 0.7 -0.6 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.5 -0.7 0.5
Age at first live birth 0.2 0.3 0.6 -0.1 -0.8
Pulse wave peak to peak time 0.3 0.3 0.6 0.3 -0.8
Health satisfaction 1.9 2.5 3.5 -1.9 -1.2
Shortness of breath walking on level ground 1.5 1.8 2.2 -1.5 -1.1
Qualifications: College or University degree 0.7 2.1 2.6 -1.6 -1.3
Eye problems/disorders: None of the above 5.1 5.9 11.8 0.1 3.4
Mouth/teeth dental problems: Loose teeth 1.0 1.2 1.6 0.9 1.2
Emphysema/chronic bronchitis 2.1 2.4 3.1 -1.8 -1.3
Medication for pain relief, constipation, heartburn 1.4 2.4 4.0 2.0 -0.9
Neck or shoulder pain in last month 1.5 2.1 2.4 -1.3 -1.6
Medication: Blood pressure 1.7 3.0 4.6 1.2 2.1
Angina (self-reported) 0.2 0.3 0.5 0.4 -0.7
Migraine (self-reported) 0.0 0.1 0.1 0.3 0.1
Medication: Ibuprofen 0.2 0.2 0.4 -0.6 0.1
Medication: Allopurinol 0.2 0.3 0.6 0.0 0.7
Medication: Omeprazole 0.0 0.0 0.0 -0.1 -0.1
Medication: Seretide 50 evohaler 4.2 4.8 9.5 -3.1 -0.3
Mean time to correctly identify matches 0.9 1.6 3.2 0.3 -1.8
Heart disease (mother) 2.3 2.8 5.0 -2.2 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.6 1.9 0.3
Whole body fat mass 1.4 5.8 8.9 -1.6 -3.0
Leg fat mass (right) 1.0 3.9 6.5 -1.1 -2.5
Arm predicted mass (right) 0.9 4.5 7.6 -1.2 -2.8
Pulse rate, automated reading 0.5 1.7 1.8 1.4 1.3
Alcohol intake frequency. 0.2 0.5 0.8 -0.4 0.9
Comparative height size at age 10 0.1 0.8 1.0 -0.8 -1.0
Number of full sisters 1.4 1.7 1.8 1.3 -1.2
Suffer from ‘nerves’ 0.7 1.1 1.5 -0.9 1.2
Overall health rating 0.3 0.6 1.2 -0.0 -1.1
Chest pain or discomfort 3.0 4.3 5.4 -2.3 -1.8
Had major operations 0.1 0.1 0.1 -0.3 0.2
Age at last live birth 0.6 0.8 1.6 -1.3 -0.1
Family relationship satisfaction 2.8 3.5 6.1 -2.5 -0.9
Leg pain on walking 1.8 2.3 3.8 -1.9 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.0 0.6
Commuting to job workplace: Car/motor vehicle 1.3 1.5 2.5 0.7 -1.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.6 0.8 -0.7
Medication: Aspirin 0.0 0.0 0.1 -0.1 0.2
Supplements: Vitamin C 0.5 0.6 0.9 0.9 -0.5
Knee pain experienced in last month 1.2 1.8 3.5 -1.9 -0.4
Hypertension (Self-reported) 0.4 1.1 2.1 1.4 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 -0.1 -0.1
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.1 0.6
Illnesses of siblings: Diabetes 0.3 0.4 0.4 -0.6 0.6
Smoking status: Previous 0.7 1.0 1.8 -1.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.9 -0.8 -2.0
Whole body fat-free mass 0.9 5.1 7.5 -1.6 -2.7
Leg fat-free mass (right) 0.9 4.6 6.2 -1.7 -2.5
Arm fat percentage (left) 0.9 3.6 6.0 -1.2 -2.4
Average weekly red wine intake 0.8 1.2 2.0 1.4 -0.7
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 0.5
Mood swings 1.6 2.8 5.1 -2.3 -0.7
Loneliness, isolation 1.3 1.8 3.4 -1.9 0.3
Long-standing illness, disability or infirmity 4.8 7.3 9.3 -3.1 -2.3
Ever had bowel cancer screening 0.5 0.6 0.9 -0.4 1.0
Diabetes diagnosed by doctor 0.3 0.5 1.1 -0.1 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.5 -1.2 -0.7
Friendships satisfaction 6.6 8.1 14.2 -3.8 -1.4
Qualifications: nursing, teaching 0.1 0.2 0.4 0.1 -0.6
Commuting to job workplace: Walk 2.8 3.0 3.2 1.7 1.8
Eye problems/disorders: Cataract 0.2 0.3 0.4 -0.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.2 0.3
Medication for cholesterol 1.6 2.4 4.8 -0.2 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 2.6 -1.6 -1.4
Back pain experienced in last month 0.6 0.8 1.1 -0.8 -1.0
Mineral and other dietary supplements 1.4 1.9 3.7 -1.9 0.1
Breast cancer (self-reported) 0.6 0.7 1.4 1.2 -0.0
Asthma (self-reported) 3.1 6.2 6.5 -2.4 -2.5
Osteoporosis (self-reported) 0.3 0.3 0.4 -0.6 -0.5
Osteoarthritis (self-reported) 1.1 1.5 2.2 -1.5 -0.8
Medication: Aspirin 0.1 0.1 0.2 0.5 0.2
Medication: Gliclazide 0.6 0.7 0.9 0.7 -0.9
Illnesses of father: None of the above (group 1) 0.3 0.3 0.6 0.1 0.8
Smoking status: Current 1.5 2.4 4.8 -0.0 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.5 7.4 14.1 0.9 -3.8
Whole body water mass 0.9 4.9 7.3 -1.6 -2.7
Leg predicted mass (right) 0.9 4.7 6.4 -1.7 -2.5
Arm fat mass (left) 1.3 5.4 8.9 -1.4 -3.0
Number of self-reported non-cancer illnesses 0.8 1.4 1.5 -1.1 -1.2
Average weekly champagne plus white wine intake 1.8 2.5 4.9 -0.4 2.2
Miserableness 2.8 4.8 7.5 -2.7 -1.5
Guilty feelings 0.8 1.2 1.9 -1.4 0.6
Wears glasses or contact lenses 3.3 3.8 4.6 -2.2 -1.7
Ever taken oral contraceptive pill 0.0 0.0 0.1 0.1 0.3
Hearing aid user 0.2 0.2 0.4 0.6 -0.1
Mother’s age at death 0.0 0.0 0.0 0.1 0.1
Financial situation satisfaction 2.0 2.4 4.4 -2.1 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.4 -0.1
Commuting to job workplace: Public transport 0.5 0.6 0.8 -0.9 0.7
Eye problems/disorders: Glaucoma 0.7 0.9 1.5 -0.5 -1.2
Medication: Blood pressure 0.6 1.1 1.3 1.1 -1.0
Pain type(s) experienced in last month: Hip pain 3.0 3.7 7.5 -2.7 -0.2
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.2 1.5 -0.5
High cholesterol (Self-reported) 0.2 0.3 0.3 -0.5 0.5
Medication: Bendroflumethiazide 1.8 2.7 2.8 1.6 1.7
Medication: Paracetamol 1.7 2.7 5.1 -0.5 2.3
Medication: Lisinopril 0.0 0.0 0.0 0.2 0.1
Medication: Atorvastatin 0.1 0.2 0.3 -0.5 -0.3
Illnesses of father: High blood pressure 0.4 0.5 0.9 -0.2 -1.0
Alcohol drinker status: Never 0.9 1.1 1.7 -0.8 1.3
Ever smoked 1.2 2.2 3.9 -0.6 -2.0
Basal metabolic rate 1.1 5.9 8.6 -1.8 -2.9
Leg fat percentage (left) 1.1 4.0 6.9 -1.0 -2.6
Arm fat-free mass (left) 1.1 5.7 9.7 -1.3 -3.1
Number of operations (self-reported) 3.2 4.7 7.1 -2.7 -1.5
Average weekly beer plus cider intake 1.5 2.2 2.9 1.2 1.7
Irritability 1.6 2.6 3.5 -1.9 1.3
Risk taking 1.4 2.1 4.1 -2.0 -0.0
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.8 -1.7 -0.5
Fractured/broken bones in last 5 years 0.3 0.4 0.6 -0.8 -0.4
Age started oral contraceptive pill 1.3 1.6 3.3 -0.0 -1.8
Diastolic blood pressure, automated reading 0.3 0.9 1.7 0.3 -1.3
Ever depressed for a whole week 2.3 2.9 5.6 -2.4 -0.3
Unable to work because of sickness or disability 0.8 1.0 1.2 -1.1 -1.0
Commuting to job workplace: Cycle 1.1 1.3 2.3 -1.5 -0.6
Myopia 0.5 0.7 1.4 1.2 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 -0.6 0.2
Cholesterol lowering medication 0.8 1.1 1.4 0.9 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 -0.2 0.7
Pain experienced in last month 0.9 1.5 2.6 1.6 -0.6
Supplements: Calcium 0.3 0.3 0.5 -0.7 -0.2
Basal cell carcinoma (self-reported) 1.0 1.2 1.4 -1.2 1.0
Heart attack/myocardial infarction (self-reported) 0.6 0.7 0.9 0.7 0.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.4 -1.2 -0.8
Heart disease (siblings) 0.9 1.1 1.3 -1.0 -1.1
Alcohol drinker status: Previous 0.2 0.2 0.4 -0.1 0.6
Pack years of smoking 0.5 0.8 1.2 1.1 -0.6
Impedance of whole body 0.0 0.1 0.1 0.3 0.1
Leg fat mass (left) 1.0 4.0 6.9 -1.1 -2.6
Arm predicted mass (left) 1.3 6.4 10.1 -1.7 -3.2