TWAS hub - KLC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2090	0.0360	5.6e-16	0.124	0.185	0.223	0.214	0.219	8.2e-15	5.5e-22	1.1e-26	1.4e-25	3.2e-26
2	NTR	Blood	0.0197	0.0077	2.1e-03	-0.001	0.003	0.000	0.002	0.000	9.4e-01	2.6e-02	3.5e-01	5.6e-02	3.3e-01
3	TCGA	Thyroid Carcinoma	0.0560	0.0240	4.8e-04	0.051	0.025	0.034	NA	0.034	9.9e-06	1.7e-03	2.8e-04	NA	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alzheimer’s Disease (including proxy)	15.1	21.9	45.6	-3.4	-6.8	-3.0
Alzheimer’s Disease (in mother)	9.0	10.5	20.3	-2.4	-4.5	-2.3
Blood Platelet Count	8.8	102.0	123.2	-11.1	-7.9	-11.0
LDL Cholesterol	7.3	11.5	33.6	-0.9	-5.8	-0.1
Diabetes (mother)	5.8	7.4	9.0	2.7	3.0	2.4
Osteoporosis (self-reported)	5.7	7.1	8.8	3.0	2.9	2.0
Smoking status: Current	5.1	8.0	9.9	2.8	3.1	2.5
Current tobacco smoking	5.0	8.2	9.2	2.9	3.0	2.7
Qualifications: College or University degree	4.7	14.7	19.2	-3.8	-4.4	-3.3
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.8	10.6	-3.2	-3.0	-3.3
Illnesses of father: Heart disease	4.3	6.0	9.7	2.8	0.3	3.1
Tinnitus: Yes, but not now, but have in the past	4.2	4.5	7.0	2.2	2.6	1.3
Qualifications: A levels/AS levels or equivalent	4.2	9.2	13.6	-3.7	-2.5	-2.8
Lung cancer (father)	4.2	4.9	7.1	2.7	2.0	1.9
Chronic bronchitis/emphysema (father)	4.1	4.8	7.3	2.7	1.2	2.4
Average weekly beer plus cider intake	4.1	5.9	7.6	2.8	2.4	2.1
Number of children fathered	4.0	4.5	5.5	-2.4	-2.3	-1.6
Qualifications: None of the above	3.9	8.2	12.7	3.6	2.4	2.6
Depression (self-reported)	3.9	4.7	6.3	2.3	1.6	2.5
Alzheimer’s Disease (in father)	3.8	4.1	11.8	-0.5	-3.4	-0.4
Townsend deprivation index at recruitment	3.8	5.3	6.9	2.6	2.5	1.7
Fractured/broken bones in last 5 years	3.6	4.6	9.1	1.9	3.0	1.1
Alcohol usually taken with meals	3.4	5.5	7.2	-2.7	-2.7	-1.5
Qualifications: CSEs or equivalent	3.3	4.4	9.2	1.6	3.0	1.2
Fluid intelligence score	3.3	6.8	7.7	-2.8	-2.4	-2.6
Average weekly champagne plus white wine intake	3.3	4.6	5.6	-2.4	-1.8	-2.3
Ulcerative Colitis	3.2	4.7	5.9	2.4	1.6	2.4
Medication: Ventolin 100micrograms inhaler	3.1	3.9	7.9	-1.9	0.3	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	7.1	-2.7	-2.6	-2.6
Risk taking	3.0	4.4	9.5	1.6	3.1	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.7	6.9	1.5	2.6	1.5
Knee pain experienced in last month	2.9	4.5	8.9	1.9	3.0	0.9
Medication: Aspirin	2.9	3.8	6.1	2.2	0.7	2.5
Ever had prostate specific antigen (PSA) test	2.9	3.3	7.8	-1.0	-2.8	-1.0
Had major operations	2.8	3.3	5.5	-1.9	-0.9	-2.3
Intelligence (Savage-Jansen 2018)	2.7	8.2	8.5	-2.9	-2.8	-2.9
Blood Red Count	2.6	24.6	29.1	5.3	4.1	5.4
Mouth/teeth dental problems: Dentures	2.6	4.5	6.1	2.5	1.1	2.5
Illness, injury, bereavement, stress in last 2 years	2.6	3.1	3.8	-1.7	-2.0	-1.6
Commuting to job workplace: Public transport	2.6	3.1	4.8	1.2	2.2	1.8
Hand grip strength (left)	2.5	6.7	9.2	-2.5	-3.0	-2.2
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.5	-1.8	-1.0	-2.1
Prostate Cancer	2.4	3.4	4.0	1.6	1.9	2.0
Supplements: Zinc	2.4	2.6	5.3	-1.5	-0.3	-2.3
Frequency of depressed mood in last 2 weeks	2.3	3.2	3.6	1.7	1.9	1.8
Ever highly irritable/argumentative for 2 days	2.3	2.7	5.3	1.3	2.3	1.2
Smoking Status	2.2	5.4	7.6	2.8	1.1	2.7
Fed-up feelings	2.2	4.0	5.8	2.4	0.9	2.3
Exposure to tobacco smoke outside home	2.2	3.0	4.1	2.0	1.1	1.9
Medication: Aspirin	2.2	2.8	4.1	2.0	0.9	1.9
Type 2 Diabetes (T2D) (2018)	2.1	3.9	7.2	1.9	0.9	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.1	1.9	0.9	2.0
Family relationship satisfaction	2.1	2.5	3.8	2.0	0.7	1.8
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	7.0	-2.6	0.2	-1.6
Alcohol intake frequency.	2.0	4.6	7.8	2.0	1.3	2.8
Medication: Paracetamol	2.0	3.1	5.7	1.8	0.6	2.4
Verbal and Numeric Reasoning (VNR)	1.9	4.7	7.3	-2.0	-2.7	-1.6
Medication for pain relief, constipation, heartburn	1.9	3.2	5.3	-2.0	-0.2	-2.3
Hand grip strength (right)	1.8	4.8	5.8	-2.1	-2.4	-2.0
Serious illness, injury or assault to yourself	1.8	2.1	5.9	0.7	2.4	0.3
Father’s age at death	1.8	2.4	4.4	-2.1	-0.7	-1.5
Age at first live birth	1.8	3.2	3.9	-2.0	-1.6	-1.8
Wears glasses or contact lenses	1.8	2.0	4.5	-1.2	-2.1	-0.4
Supplements: Calcium	1.8	2.0	5.4	0.6	2.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.1	-1.7	-2.3	-1.6
Ever had bowel cancer screening	1.7	2.0	4.6	-1.1	0.5	-2.1
Ulcerative Colitis (UC)	1.6	3.1	4.8	1.9	0.9	2.2
Sensitivity / hurt feelings	1.6	2.7	4.5	1.9	0.2	2.1
Maternal smoking around birth	1.6	2.3	3.8	1.4	2.0	1.1
Migraine (self-reported)	1.6	2.0	3.7	-1.9	-1.2	-1.0
Heel T-Score	1.5	11.8	13.8	-3.4	-3.7	-3.1
Hypothyroidism (self reported)	1.5	3.5	8.2	0.8	-2.9	1.2
Alcohol intake versus 10 years previously	1.5	2.3	3.3	1.3	1.4	1.8
Overall health rating	1.5	3.2	5.7	2.4	1.1	1.7
Qualifications: nursing, teaching	1.5	2.3	3.8	-2.0	-0.6	-1.6
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.1	1.4	1.8	0.6
Severe depression (siblings)	1.4	1.5	3.7	0.9	1.9	-0.3
Heart attack	1.4	1.8	2.5	-1.0	-1.6	-1.4
Diabetes (self-reported)	1.4	2.2	3.8	1.6	0.4	1.9
Financial situation satisfaction	1.4	1.8	3.0	1.4	0.7	1.7
Crohns Disease (2017)	1.3	2.8	4.0	-1.4	-2.0	-1.5
Mouth/teeth dental problems	1.3	2.0	2.7	-1.6	-1.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.2	-0.4	-2.1	0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.7	1.0	1.9	0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.2	-1.0	-1.3	-1.5
Pain experienced in last month	1.3	2.2	2.9	-1.7	-1.4	-1.3
Basal cell carcinoma (self-reported)	1.3	1.6	2.6	1.6	0.1	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	-0.8	-1.7	-1.2
Neuroticism (2016)	1.2	1.8	3.6	0.9	-1.0	1.9
Blood Eosinophil Count	1.2	9.0	15.4	-3.4	-0.5	-3.9
Chronotype (morning person)	1.2	2.7	3.4	-1.8	-1.1	-1.8
Hearing difficulty/problems with background noise	1.2	2.0	3.5	-1.9	-0.3	-1.5
Medication: Simvastatin	1.2	1.7	2.7	0.4	-1.5	1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.2	1.0	1.8	0.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.3	0.3	-2.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.5	1.6	-0.2	1.3
Depression (Nagel 2018)	1.1	1.6	2.6	1.5	0.0	1.6
Schizophrenia (2018)	1.1	2.3	3.5	1.8	0.5	1.9
Mean Putamen Volume	1.1	1.3	3.6	0.1	1.9	-0.4
Triglycerides	1.1	1.8	2.1	1.4	1.1	1.4
Birth weight of first child	1.1	2.0	3.9	-0.8	-2.0	-1.3
Average weekly red wine intake	1.1	1.6	2.0	-1.4	-1.3	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	1.4	1.1	0.6
Back pain experienced in last month	1.1	1.7	3.1	1.8	1.2	0.7
Illnesses of father: None of the above (group 1)	1.1	1.4	1.4	-1.2	1.2	-1.2
Hair/balding pattern: Pattern 2	1.0	1.3	2.1	-1.3	-0.5	-1.5
Financial difficulties in last 2 years	1.0	1.4	1.8	1.4	0.8	1.3
Illnesses of mother	1.0	1.2	2.0	1.2	1.4	0.6
Exposure to tobacco smoke at home	1.0	1.1	2.6	0.7	1.6	0.2
Medication: Paracetamol	1.0	1.6	2.5	1.4	0.6	1.6
Leg pain on walking	1.0	1.2	1.6	1.3	1.1	0.9
Long-standing illness, disability or infirmity	1.0	1.5	2.7	1.0	1.6	0.9
Illnesses of father: High blood pressure	1.0	1.3	2.6	-1.6	-0.2	-1.1
Irritability	1.0	1.7	3.1	1.4	-0.3	1.8
Bipolar Disorder or Schizophrenia	0.9	2.2	3.2	1.7	0.6	1.8
Medication: Metformin	0.9	1.3	2.4	1.2	0.3	1.6
Nervous feelings	0.9	1.6	2.6	1.5	0.1	1.6
Health satisfaction	0.9	1.2	1.8	1.2	1.3	0.6
Medication: Omeprazole	0.9	1.1	1.7	-1.0	-1.3	-0.8
Diabetes diagnosed by doctor	0.9	1.6	2.8	1.3	0.5	1.7
Osteoarthritis (self-reported)	0.9	1.1	1.7	0.9	1.3	0.9
Alcohol drinker status: Never	0.9	1.1	1.8	1.2	0.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.5	1.0	1.2	1.1
Crohns Disease (2012)	0.8	1.2	1.8	-1.0	-1.0	-1.3
Fasting Glucose	0.8	0.9	2.2	-0.0	1.5	-0.7
Average weekly spirits intake	0.8	1.0	1.2	1.0	0.9	1.1
Diabetes (father)	0.8	1.0	1.4	0.6	1.1	1.2
Age when periods started (menarche)	0.8	2.0	2.4	1.4	1.6	1.3
Hair/balding pattern: Pattern 3	0.8	1.2	2.9	0.4	-0.7	1.7
Asthma	0.8	1.5	1.8	-1.3	-1.1	-1.2
Hair/balding pattern: Pattern 4	0.8	2.0	5.7	-0.3	-2.4	-0.6
Pulse wave peak to peak time	0.8	1.0	1.5	-1.1	-0.5	-1.2
Mean time to correctly identify matches	0.8	1.5	2.1	1.5	0.8	1.3
Schizophrenia (2014)	0.7	1.6	1.7	1.2	1.3	1.3
Blood White Count	0.7	5.1	5.9	-2.4	-2.1	-2.2
BMI	0.7	4.0	6.2	1.6	1.8	2.5
Medication: Levothyroxine sodium	0.7	1.3	3.7	-0.1	-1.9	0.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.7	0.9	-0.0	1.3
Pain all over the body in last month	0.7	0.8	1.4	0.7	0.6	1.2
Neuroticism score	0.7	1.5	2.2	1.5	0.1	1.5
Noisy workplace	0.7	0.8	2.0	0.4	1.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.6	0.8	1.3	1.0
Blood clot in the leg (DVT)	0.7	0.9	1.1	0.8	1.0	1.0
Worry too long after embarrassment	0.7	1.2	1.6	1.0	-1.2	1.0
Emphysema/chronic bronchitis	0.7	0.8	2.1	0.4	1.5	-0.4
Chest pain or discomfort	0.7	1.0	2.6	-0.7	0.2	-1.6
Smoking status: Previous	0.7	1.0	2.9	-0.1	-1.7	-0.2
Mineral and other dietary supplements	0.7	0.9	2.4	-0.5	-1.6	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	1.2	0.9	0.8
High cholesterol (Self-reported)	0.7	1.2	2.0	-1.2	-1.4	-0.2
Heart disease (siblings)	0.7	0.9	1.7	1.3	0.5	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	1.1	-0.5	0.8
Angina	0.6	0.8	2.2	0.1	-1.5	0.3
Pack years adult smoking proportion	0.6	0.9	2.1	0.4	1.4	0.6
Average weekly fortified wine intake	0.6	0.7	1.3	-0.8	0.6	-1.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.0	-1.3	-0.7	-1.4
Medication: Atenolol	0.6	0.8	1.1	0.9	-0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	1.0	-0.2	1.3
Allergy	0.6	1.4	2.5	1.2	0.6	1.6
Falls in the last year	0.6	0.8	1.5	0.9	1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	0.9	0.8	0.9	0.6
Tense / ‘highly strung’	0.6	1.0	2.3	-0.1	1.5	-0.8
Peak expiratory flow (PEF)	0.6	1.4	2.5	1.1	0.6	1.6
Pulse wave reflection index	0.6	0.7	1.1	1.1	0.3	0.9
High blood pressure (siblings)	0.6	0.8	1.7	0.5	1.3	0.7
Comparative body size at age 10	0.6	1.8	2.4	-1.4	-1.6	-0.9
Number of full brothers	0.6	0.8	0.8	-0.9	-0.8	-0.9
Wheeze or whistling in the chest in last year	0.6	1.1	1.5	1.0	1.2	0.9
Neck or shoulder pain in last month	0.6	0.9	1.4	-1.2	0.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-1.1	-0.8	-0.5
Mood swings	0.6	1.0	1.8	1.3	0.6	1.0
Ever smoked	0.6	1.0	2.0	1.4	-0.2	1.0
Diastolic blood pressure, automated reading	0.6	1.9	2.5	1.3	1.2	1.6
Myopia	0.6	0.8	2.2	-0.0	1.5	-0.4
Cholesterol lowering medication	0.6	0.8	1.8	0.2	-1.4	0.8
Neuroticism (Nagel 2018)	0.5	1.2	2.7	0.7	-1.6	0.5
Breast Cancer	0.5	1.1	1.3	-1.1	-1.1	-1.0
Primary Biliary Cirrhosis	0.5	0.7	1.0	1.0	0.5	0.9
Allergy or Eczema	0.5	1.3	1.9	-1.2	-0.8	-1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.5	1.3	-0.1
Had menopause	0.5	0.6	1.6	-0.2	-1.3	-0.4
Medication: Ramipril	0.5	0.6	1.4	-0.4	-1.2	0.5
Time employed in main current job	0.5	0.6	0.8	-0.9	-0.9	-0.3
Medication: Lansoprazole	0.5	0.6	0.8	0.5	0.9	-0.8
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	0.8	0.0	1.0
Trunk predicted mass	0.5	2.8	7.0	-1.1	-2.6	-0.0
Length of working week for main job	0.5	0.6	1.3	0.6	1.1	-0.3
Pulse rate, automated reading	0.5	1.7	4.4	0.8	2.1	0.2
Friendships satisfaction	0.5	0.6	1.5	0.3	-1.2	0.5
Hearing aid user	0.5	0.6	0.9	0.9	-0.5	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	1.1	-0.8	0.8
Body Mass Index (BMI) (2010)	0.4	0.6	0.7	-0.9	-0.8	-0.6
Lung FEV1/FVC ratio	0.4	1.9	4.6	1.0	-0.2	2.1
Relative age of first facial hair	0.4	0.7	1.0	1.0	0.9	0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	-0.5	-0.8	-0.6
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.7	-0.4	-0.9
Multivitamins +/- minerals	0.4	0.5	0.8	-0.3	0.7	-0.9
Waist circumference	0.4	1.3	2.6	0.7	1.6	1.0
Had other major operations	0.4	0.4	1.2	0.4	1.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.5	-0.5	-0.9
Trunk fat-free mass	0.4	2.6	6.6	-1.1	-2.6	0.0
Number of live births	0.4	0.6	0.8	0.9	-0.7	0.7
Pulse rate	0.4	0.7	2.0	-0.1	1.4	-0.4
Medication: Cholesterol lowering	0.4	0.6	1.6	-0.3	-1.3	-0.0
Standing height	0.4	3.8	9.3	-1.1	-3.0	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.7	0.8	0.6	0.6
Angina (self-reported)	0.4	0.6	1.5	0.2	-1.2	0.4
Medication: Ibuprofen	0.4	0.5	0.8	0.5	0.7	0.9
Age at last live birth	0.4	0.5	1.1	-0.6	-1.1	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.9	1.0	0.3	0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	-0.9	-0.8	-0.3
Loneliness, isolation	0.4	0.6	1.0	1.0	0.6	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.3	-0.2	-1.1	0.1
Number of self-reported non-cancer illnesses	0.4	0.6	0.7	-0.8	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	-0.7	-0.8	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	-0.3	1.1	-0.3
Number of operations (self-reported)	0.4	0.6	0.8	-0.4	-0.9	-0.9
Pack years of smoking	0.4	0.6	1.6	0.3	1.2	0.5
Age at First Birth	0.3	0.5	0.8	-0.2	0.9	-0.8
Neuroticism	0.3	0.8	1.3	1.0	-0.5	1.1
Systolic blood pressure, automated reading	0.3	0.7	1.3	0.5	-0.7	1.1
Medication: Co-codamol	0.3	0.4	0.9	-0.4	0.2	-1.0
Impedance of leg (right)	0.3	1.7	3.1	-1.2	-0.7	-1.8
Trunk fat percentage	0.3	1.1	2.9	0.5	1.7	0.5
Taking other prescription medications	0.3	0.4	1.0	0.4	1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	-0.2	-0.7	-0.7
Supplements: Glucosamine	0.3	0.4	1.2	-0.2	0.1	-1.1
Sitting height	0.3	1.8	2.1	-1.4	-1.4	-1.2
High blood pressure (mother)	0.3	0.5	0.9	-0.9	-0.5	-0.5
Impedance of leg (left)	0.3	1.4	2.9	-1.0	-0.4	-1.7
Illnesses of siblings	0.3	0.4	0.7	-0.8	-0.6	-0.2
Arm fat percentage (right)	0.3	1.1	3.1	0.1	1.8	0.2
Worrier / anxious feelings	0.3	0.6	1.6	-0.0	-1.3	0.4
Prospective memory result	0.3	0.4	0.8	0.9	0.4	0.3
Breastfed as a baby	0.3	0.4	0.8	-0.0	0.9	-0.7
Loud music exposure frequency	0.3	0.3	0.8	0.1	0.9	0.4
Medication: Amlodipine	0.3	0.4	0.9	-1.0	-0.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.4	0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.5	-0.7	-0.7	-0.6
Asthma (self-reported)	0.3	0.6	0.9	-0.8	-0.6	-0.9
Guilty feelings	0.3	0.5	1.4	-0.1	-1.2	-0.3
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.3	-0.4	-0.9
Medication: Lisinopril	0.3	0.4	0.8	0.7	-0.3	0.9
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	-0.6	0.7	-1.3
Reaction Time	0.2	0.4	0.8	0.5	0.9	0.3
Ovarian Cancer	0.2	0.3	0.6	-0.5	-0.4	-0.8
HDL Cholesterol	0.2	0.4	0.7	-0.5	0.8	-0.4
Lupus	0.2	0.2	0.7	0.1	-0.9	-0.1
Height	0.2	4.6	10.2	-1.5	-3.2	-1.2
Tanning	0.2	1.9	4.2	1.2	0.3	2.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.2	0.1	-0.9
Vitamin and mineral supplements	0.2	0.3	0.6	-0.5	-0.7	-0.1
High blood pressure	0.2	0.5	1.4	0.5	0.0	1.2
Body mass index (BMI)	0.2	0.9	1.7	0.3	1.3	0.9
Number of incorrect matches in round	0.2	0.3	0.9	-0.2	-0.0	-0.9
Past tobacco smoking	0.2	0.5	0.7	-0.7	0.9	-0.4
Forced vital capacity (FVC)	0.2	0.7	1.2	-0.8	-0.5	-1.1
Impedance of arm (right)	0.2	0.8	1.3	1.1	1.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	0.5	0.5	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.2	0.7	0.3
Headache pain in last month	0.2	0.3	0.4	-0.6	-0.6	-0.5
Glaucoma (self-reported)	0.2	0.2	0.7	0.1	0.9	-0.0
Birth weight	0.2	0.4	1.2	0.1	0.1	-1.1
Forced vital capacity (FVC), Best measure	0.2	0.6	0.7	-0.8	-0.7	-0.9
Body fat percentage	0.2	0.9	2.5	0.1	1.6	0.1
Arm fat-free mass (right)	0.2	1.1	2.6	-0.9	-1.6	-0.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.4	0.7	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.2	0.5	-0.5
Heart disease (mother)	0.2	0.2	0.4	-0.2	0.6	-0.4
Arm predicted mass (right)	0.2	1.1	2.6	-0.7	-1.6	0.0
Comparative height size at age 10	0.2	1.3	2.8	-0.8	-1.7	-0.7
Number of full sisters	0.2	0.2	0.4	-0.2	-0.5	-0.6
Supplements: Vitamin C	0.2	0.2	0.6	-0.1	0.8	0.1
Hypertension (Self-reported)	0.2	0.7	1.5	0.7	0.3	1.2
Whole body fat-free mass	0.2	1.2	3.0	-0.7	-1.7	0.1
Arm fat percentage (left)	0.2	0.8	2.2	0.1	1.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.4	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.7	-0.8	-0.4	-0.8
Whole body water mass	0.2	1.3	3.2	-0.8	-1.8	0.1
Mother’s age at death	0.2	0.3	0.6	-0.3	0.4	-0.8
Arm fat-free mass (left)	0.2	1.0	1.8	-1.1	-1.3	-0.3
Age started oral contraceptive pill	0.2	0.3	0.4	0.6	-0.4	0.5
Ever depressed for a whole week	0.2	0.3	0.3	0.4	0.5	0.6
Unable to work because of sickness or disability	0.2	0.2	0.4	0.7	0.0	0.5
Alcohol drinker status: Previous	0.2	0.3	0.5	-0.5	-0.1	-0.7
Arm predicted mass (left)	0.2	0.9	1.5	-1.1	-1.2	-0.3
Bipolar Disorder (2018)	0.1	0.2	0.3	0.5	0.3	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	-0.2	0.5
Irritable Bowel Disease (IBD)	0.1	0.4	0.4	0.7	-0.5	0.6
Major Depression (MDD)	0.1	0.2	0.4	0.1	-0.6	0.3
HbA1C	0.1	0.1	0.1	0.3	-0.0	0.3
Waist Hip Ratio (WHR)	0.1	0.6	0.8	0.8	0.9	0.6
Systolic Blood Pressure	0.1	0.4	0.6	-0.8	-0.4	-0.8
Cardiovascular Disease	0.1	0.4	0.8	0.0	-0.5	0.9
Hair Pigment	0.1	3.5	8.5	1.4	2.9	-0.2
Number of treatments/medications taken	0.1	0.1	0.3	-0.1	0.5	-0.4
Relative age voice broke	0.1	0.2	0.3	-0.3	0.5	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.3	0.4
Trunk fat mass	0.1	0.3	0.6	0.1	0.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	-0.5	-0.5	-0.3
Arm fat mass (right)	0.1	0.3	0.9	-0.3	0.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.4	0.5	0.0
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	0.0	0.1	0.7
Leg fat percentage (right)	0.1	0.4	0.7	-0.9	0.5	-0.5
Shortness of breath walking on level ground	0.1	0.2	0.2	-0.5	0.5	-0.1
Whole body fat mass	0.1	0.4	1.0	-0.0	1.0	0.3
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.2	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.0	-0.1	0.4
Medication for cholesterol	0.1	0.1	0.3	0.1	0.6	-0.3
Medication: Gliclazide	0.1	0.1	0.1	-0.3	-0.4	-0.2
Arm fat mass (left)	0.1	0.3	0.5	-0.5	0.7	0.1
Medication: Blood pressure	0.1	0.3	0.7	-0.1	-0.8	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.3	0.5	-0.1
Medication: Atorvastatin	0.1	0.1	0.3	0.2	0.4	-0.5
Basal metabolic rate	0.1	0.8	1.9	-0.7	-1.4	0.1
Leg fat percentage (left)	0.1	0.4	0.6	-0.8	0.7	-0.5
Commuting to job workplace: Cycle	0.1	0.2	0.2	0.4	0.5	0.3
Impedance of whole body	0.1	0.4	0.6	0.3	0.7	-0.7
Leg fat mass (left)	0.1	0.2	0.4	-0.6	0.6	-0.1
Worry (Nagel 2018)	0.0	0.1	0.3	0.0	-0.6	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.1
Respiratory disease	0.0	0.1	0.2	-0.1	0.3	-0.4
Lung FVC	0.0	0.1	0.3	0.1	0.5	-0.2
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.1	-0.1	0.1
Leg fat-free mass (left)	0.0	0.1	0.2	-0.1	-0.4	0.4
Leg predicted mass (left)	0.0	0.1	0.2	-0.1	-0.4	0.3
Weight	0.0	0.1	0.2	-0.2	-0.1	0.5
Hip circumference	0.0	0.1	0.2	-0.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.2	0.1	-0.3
Happiness	0.0	0.0	0.1	0.2	0.1	-0.2
Impedance of arm (left)	0.0	0.2	0.3	0.6	0.1	-0.4
Gout (self-reported)	0.0	0.1	0.1	-0.2	-0.0	-0.3
Medication: Blood pressure	0.0	0.0	0.1	-0.2	0.3	-0.1
Medication: Allopurinol	0.0	0.1	0.1	0.4	-0.0	0.3
Leg fat mass (right)	0.0	0.2	0.4	-0.6	0.4	-0.1
Leg fat-free mass (right)	0.0	0.1	0.2	0.1	-0.3	0.4
Breast cancer (self-reported)	0.0	0.0	0.1	0.2	-0.1	0.1
Leg predicted mass (right)	0.0	0.1	0.2	0.0	-0.3	0.4
Miserableness	0.0	0.0	0.1	0.1	0.3	0.1

Hub : Genes

KLC3

Models

Trait associations