TWAS hub - MIR4519

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.135	0.059	0.0031	0.046	NA	-0.006	NA	0.042	0.0038	NA	0.720	NA	0.0056
2	GTEx	Thyroid	0.095	0.044	0.0021	0.005	NA	0.007	NA	0.012	0.1300	NA	0.084	NA	0.0370

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lupus	46.8	70.8	141.6	-11.9	0.2
Cholesterol lowering medication	8.6	12.6	14.1	-3.8	-3.4
Forced vital capacity (FVC), Best measure	8.3	30.3	57.2	1.9	7.6
Fractured/broken bones in last 5 years	8.0	10.4	16.0	-4.0	-2.2
Forced vital capacity (FVC)	7.8	30.2	57.3	1.8	7.6
Forced expiratory volume in 1-second (FEV1), Best measure	7.1	22.5	40.6	2.1	6.4
Illnesses of father: None of the above (group 1)	7.0	8.7	15.2	-1.5	3.9
Irritability	7.0	11.8	17.6	2.5	4.2
Forced expiratory volume in 1-second (FEV1)	6.4	21.5	39.4	1.9	6.3
Hearing difficulty/problems: Yes	6.3	9.6	14.7	-2.1	-3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.0	12.6	12.6	3.5	3.5
Prospective memory result	5.2	6.5	6.8	2.6	2.5
Medication: Ramipril	5.1	6.5	10.6	-3.3	-1.5
Lung cancer (father)	5.0	5.8	11.6	0.3	3.4
Hip circumference	4.9	21.3	31.2	-5.6	-3.4
Lung FVC	4.7	23.7	37.7	3.1	6.1
Ever had hysterectomy (womb removed)	4.5	5.0	5.6	-2.4	-2.1
Relative age voice broke	4.5	6.9	9.9	-3.1	-2.0
Neuroticism score	4.4	9.2	17.2	1.1	4.1
Leg fat percentage (right)	4.3	15.5	15.5	-3.9	-3.9
Leg fat percentage (left)	4.2	15.2	17.1	-4.1	-3.6
Neuroticism	4.1	9.8	18.3	1.2	4.3
Illnesses of siblings	4.1	5.8	6.3	2.5	2.3
Deep venous thrombosis (DVT) (self-reported)	4.0	5.1	8.9	-1.2	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.9	4.7	7.4	-1.4	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	6.7	2.6	1.6
Medication: Atorvastatin	3.9	4.8	6.0	-2.5	-1.9
Breast Cancer	3.8	9.1	12.2	-2.5	-3.5
Blood clot in the leg (DVT)	3.7	4.7	8.2	-1.1	-2.9
Body fat percentage	3.7	14.6	18.6	-4.3	-3.3
Chronic bronchitis/emphysema (father)	3.6	4.2	8.4	-0.2	-2.9
Loud music exposure frequency	3.6	4.0	7.2	-0.9	-2.7
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	9.0	3.0	0.5
Neuroticism (Nagel 2018)	3.4	7.9	12.8	1.8	3.6
Body mass index (BMI)	3.4	14.7	21.4	-4.6	-2.8
Illnesses of father: Heart disease	3.4	4.7	5.1	2.3	-2.1
Average weekly champagne plus white wine intake	3.4	4.6	6.6	-1.6	-2.6
Tinnitus: Yes, now most or all of the time	3.4	4.0	6.9	-2.6	-1.1
High cholesterol (Self-reported)	3.4	6.0	11.5	-0.7	-3.4
Leg fat mass (left)	3.4	13.1	19.1	-4.4	-2.7
Leg fat mass (right)	3.3	12.9	18.8	-4.3	-2.6
Medication for cholesterol	3.3	5.0	5.8	2.4	2.1
Osteoporosis (self-reported)	3.3	4.1	8.1	-2.9	0.4
Waist circumference	3.2	11.8	20.6	-4.5	-1.7
High blood pressure (siblings)	3.2	4.7	5.8	-2.4	-1.9
Arm fat percentage (right)	3.1	12.4	17.6	-4.2	-2.7
Arm fat percentage (left)	3.1	12.3	18.2	-4.3	-2.5
Arm fat mass (left)	3.1	12.8	21.2	-4.6	-2.1
Hearing aid user	3.1	3.5	4.5	-1.6	-2.1
Trunk fat percentage	3.0	12.0	16.6	-4.1	-2.7
Fluid intelligence score	3.0	6.2	11.8	-0.7	-3.4
Arm fat mass (right)	3.0	12.4	20.9	-4.6	-2.0
Tense / ‘highly strung’	3.0	5.0	8.4	1.3	2.9
Whole body fat mass	3.0	12.3	19.7	-4.4	-2.2
Medication: Aspirin	3.0	3.9	6.2	-1.3	-2.5
Blood Red Count	2.9	28.0	36.5	4.4	6.0
Fed-up feelings	2.9	5.4	10.7	0.1	3.3
Number of incorrect matches in round	2.9	4.8	5.5	2.3	2.0
Medication: Cholesterol lowering	2.8	4.3	8.1	-0.7	-2.9
Chest pain or discomfort	2.8	4.1	6.3	-1.4	-2.5
Trunk fat mass	2.7	11.4	19.1	-4.4	-1.9
Number of full brothers	2.7	3.4	4.9	-2.2	-1.4
Health satisfaction	2.7	3.5	4.1	-2.0	-1.7
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	4.9	2.2	-0.9
Medication: Simvastatin	2.6	3.9	5.5	-1.5	-2.3
Worry too long after embarrassment	2.6	4.4	7.4	1.2	2.7
Medication: Aspirin	2.6	3.4	3.9	-1.7	-2.0
Pain experienced in last month	2.6	4.4	8.1	0.8	2.8
Pack years of smoking	2.6	3.8	4.1	-1.9	-2.0
Primary Biliary Cirrhosis	2.5	3.5	6.8	-2.6	0.5
Blood Eosinophil Count	2.5	19.5	25.6	5.1	-3.7
Weight	2.5	12.2	23.6	-4.9	-0.9
Guilty feelings	2.5	3.8	7.5	0.2	2.7
Medication: Bendroflumethiazide	2.5	3.8	5.8	-2.4	1.3
Prostate Cancer	2.4	3.4	3.4	1.8	1.9
Mean Putamen Volume	2.4	2.7	3.0	-1.7	1.5
Had menopause	2.4	3.0	4.2	-2.0	-1.4
Supplements: Zinc	2.3	2.5	2.6	1.6	1.5
Illnesses of mother	2.3	2.9	4.5	2.1	1.1
Diastolic blood pressure, automated reading	2.3	7.0	11.8	-3.4	1.5
Depressed Affect (Nagel 2018)	2.2	4.7	9.3	-0.2	3.0
Waist Hip Ratio (WHR)	2.2	9.8	16.0	1.9	4.0
Medication: Seretide 50 evohaler	2.2	2.5	4.7	2.2	-0.6
Overall health rating	2.2	4.6	6.4	-1.7	-2.5
Smoking status: Previous	2.2	3.4	5.0	-1.3	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	4.5	2.1	0.8
Vascular/heart problems diagnosed by doctor	2.2	6.0	11.4	3.4	0.8
Worry (Nagel 2018)	2.1	4.5	5.0	2.2	2.0
Neuroticism (2016)	2.1	3.0	4.1	1.3	2.0
BMI	2.1	12.2	16.9	-4.1	-2.7
Sensitivity / hurt feelings	2.1	3.5	6.2	0.9	2.5
Medication: Allopurinol	2.1	2.7	5.0	2.2	-0.7
Medication: Blood pressure	2.1	4.0	8.0	-2.8	-0.2
HDL Cholesterol	2.0	3.4	5.2	2.3	1.3
Smoking Status	2.0	4.8	7.5	-1.5	-2.7
Relative age of first facial hair	2.0	4.1	8.1	-2.8	0.4
Father’s age at death	2.0	2.7	3.6	1.9	1.3
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.7	0.1	-2.2
Knee pain experienced in last month	2.0	3.1	5.3	-1.0	-2.3
Major Depression (MDD)	1.9	2.3	2.6	1.6	1.4
Verbal and Numeric Reasoning (VNR)	1.9	4.6	9.1	0.5	-3.0
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.4	-0.2	2.1
Heart attack	1.9	2.5	4.8	-0.4	-2.2
Comparative body size at age 10	1.9	5.2	6.5	-2.5	-2.0
Crohns Disease (2012)	1.8	3.0	5.8	2.4	0.3
Shortness of breath walking on level ground	1.8	2.1	4.1	-0.4	-2.0
Blood White Count	1.7	12.8	25.6	5.1	-0.1
Pack years adult smoking proportion	1.7	2.6	2.9	-1.7	-1.5
Peak expiratory flow (PEF)	1.7	3.9	6.4	1.2	2.5
Glaucoma (self-reported)	1.7	2.0	3.5	0.6	1.9
Wheeze or whistling in the chest in last year	1.7	3.0	6.1	-0.1	-2.5
Arm predicted mass (right)	1.7	8.7	17.3	-4.2	0.4
Medication: Paracetamol	1.7	2.6	2.9	-1.5	-1.7
Arm fat-free mass (left)	1.7	8.5	17.0	-4.1	0.1
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.1	-0.6	-2.0
Arm predicted mass (left)	1.7	8.7	17.2	-4.2	-0.3
Coronary Artery Disease (CAD)	1.6	1.9	3.3	1.8	-0.7
Triglycerides	1.6	2.6	2.7	-1.5	-1.6
Ulcerative Colitis	1.6	2.3	4.2	2.1	-0.7
Diabetes (mother)	1.6	2.0	3.0	-1.7	-1.0
Worrier / anxious feelings	1.6	3.0	3.4	1.9	1.6
Arm fat-free mass (right)	1.6	8.2	16.4	-4.0	0.3
Mood swings	1.6	2.9	5.8	0.1	2.4
Irritable Bowel Disease (IBD)	1.5	3.6	5.3	2.3	1.4
Ulcerative Colitis (UC)	1.5	2.9	5.5	2.3	0.5
Cardiovascular Disease	1.5	5.1	6.2	-2.5	-2.0
Allergy	1.5	3.6	4.5	-2.1	1.6
Number of live births	1.5	2.1	3.9	-2.0	0.6
Happiness	1.5	1.8	2.5	1.0	1.6
Commuting to job workplace: Walk	1.5	1.7	3.3	0.2	1.8
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.6	-0.3	-2.2
Basal metabolic rate	1.5	8.5	16.4	-4.0	0.8
Risk taking	1.5	2.2	4.2	-0.5	-2.1
Myopia	1.5	2.2	2.7	-1.3	-1.7
LDL Cholesterol	1.4	2.3	3.7	-0.9	-1.9
Leg fat-free mass (left)	1.4	7.6	14.4	-3.8	0.9
Leg predicted mass (left)	1.4	7.5	14.2	-3.8	0.8
Medication: Lansoprazole	1.4	1.6	3.2	-0.3	-1.8
Medication: Paracetamol	1.4	2.4	3.0	-1.3	-1.7
Medication: Amlodipine	1.4	1.9	3.2	1.8	0.8
Medication for pain relief, constipation, heartburn	1.4	2.3	4.1	0.7	2.0
Leg fat-free mass (right)	1.4	7.3	12.6	-3.5	1.4
Friendships satisfaction	1.4	1.7	2.0	1.4	1.2
Leg predicted mass (right)	1.4	7.3	12.5	-3.5	1.4
Illnesses of father: High blood pressure	1.4	1.8	3.5	0.2	-1.9
Age when periods started (menarche)	1.3	3.1	5.2	-1.0	2.3
Falls in the last year	1.3	1.8	3.5	0.1	-1.9
Asthma	1.3	2.5	2.7	1.5	-1.6
Headache pain in last month	1.3	2.2	3.9	-0.8	-2.0
Alcohol intake frequency.	1.3	3.1	5.9	-2.4	0.5
Whole body fat-free mass	1.3	7.5	13.4	-3.7	1.3
Whole body water mass	1.3	7.4	13.3	-3.6	1.2
Number of self-reported non-cancer illnesses	1.3	2.2	3.3	-1.0	-1.8
Eye problems/disorders: Glaucoma	1.3	1.5	3.1	0.1	1.8
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.4	1.1	-2.5
Heel T-Score	1.2	9.2	18.1	4.3	0.6
Severe depression (siblings)	1.2	1.4	2.6	1.6	0.5
High blood pressure	1.2	3.4	6.8	-2.6	-0.2
Hearing difficulty/problems with background noise	1.2	1.9	2.8	-1.0	-1.7
Trunk fat-free mass	1.2	7.0	11.8	-3.4	1.5
Hair/balding pattern: Pattern 3	1.2	1.8	2.0	-1.3	-1.4
Trunk predicted mass	1.2	7.1	11.7	-3.4	1.6
Number of children fathered	1.2	1.4	1.6	-1.3	-1.1
Hypertension (Self-reported)	1.2	3.4	6.7	-2.6	-0.3
Long-standing illness, disability or infirmity	1.2	1.9	3.4	0.6	-1.8
Asthma (self-reported)	1.2	2.4	2.4	1.6	-1.5
Reaction Time	1.1	2.1	4.0	0.3	-2.0
Number of treatments/medications taken	1.1	2.0	2.2	-1.5	-1.4
Supplements: Glucosamine	1.1	1.4	2.6	1.6	-0.5
Past tobacco smoking	1.1	2.0	3.6	0.7	1.9
Ever highly irritable/argumentative for 2 days	1.1	1.4	1.8	1.4	0.9
Medication: Ibuprofen	1.1	1.3	2.5	-1.6	-0.3
Mean time to correctly identify matches	1.1	2.0	4.0	0.3	-2.0
Diabetes diagnosed by doctor	1.1	1.9	3.1	0.8	-1.8
Crohns Disease (2017)	1.0	2.3	2.8	1.3	1.7
Blood Platelet Count	1.0	11.3	22.3	-0.5	-4.7
Respiratory disease	1.0	2.2	3.9	2.0	-0.7
Qualifications: CSEs or equivalent	1.0	1.4	2.5	-0.4	1.6
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.4	2.1	0.2
Nervous feelings	1.0	2.0	3.2	1.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.0	1.7	0.4
Had other major operations	1.0	1.2	1.3	-1.0	1.1
Impedance of arm (right)	1.0	4.8	6.5	2.5	1.8
Standing height	1.0	9.7	18.4	-1.0	4.3
Exposure to tobacco smoke outside home	1.0	1.3	1.8	-0.9	-1.3
Qualifications: nursing, teaching	1.0	1.5	3.0	1.7	-0.2
Heart disease (siblings)	1.0	1.2	2.1	-1.4	-0.6
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.6	-1.3	0.7
Height	0.9	16.6	27.1	-2.5	5.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	2.6	1.6	1.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	1.8	1.3	0.7
Illnesses of siblings: Diabetes	0.9	1.1	2.1	-0.0	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.9	0.1	2.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.0	-0.4	-1.4
Loneliness, isolation	0.9	1.2	2.2	-0.4	1.5
Miserableness	0.9	1.5	2.9	-0.5	1.7
Ever depressed for a whole week	0.9	1.1	1.2	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	1.5	-0.3
HbA1C	0.8	0.9	1.8	-0.0	-1.4
Allergy or Eczema	0.8	2.1	3.6	1.9	-0.7
Hand grip strength (left)	0.8	2.1	3.1	-1.8	-1.0
Stomach or abdominal pain in last month	0.8	1.0	1.2	0.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-1.3	-0.6
Impedance of arm (left)	0.8	3.9	4.8	2.2	1.7
Length of working week for main job	0.8	0.9	1.3	-0.6	1.1
Migraine (self-reported)	0.8	1.0	1.4	0.7	-1.2
Number of full sisters	0.8	0.9	1.9	0.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.6	-0.6	-1.3
Commuting to job workplace: Cycle	0.8	0.9	1.8	1.3	-0.2
Average weekly spirits intake	0.7	0.8	1.5	-0.3	-1.2
Pain all over the body in last month	0.7	0.7	1.3	-0.3	-1.1
Had major operations	0.7	0.8	1.1	-1.1	-0.7
Medication: Gliclazide	0.7	0.8	1.2	1.1	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.5	-1.2	0.4
Impedance of whole body	0.7	3.7	6.5	2.5	0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	1.2	-0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.1	-1.1	-0.7
Townsend deprivation index at recruitment	0.6	0.8	1.6	-0.1	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	1.6	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.1	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	0.2	1.4
Pulse wave peak to peak time	0.6	0.7	1.0	1.0	0.5
Medication: Omeprazole	0.6	0.8	1.2	1.1	0.6
Leg pain on walking	0.6	0.7	1.1	0.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	1.2	0.1
Medication: Lisinopril	0.6	0.8	0.9	-0.9	1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	1.2	-0.1
Rheumatoid Arthritis	0.5	0.6	1.1	-0.4	1.1
Hypothyroidism (self reported)	0.5	1.1	2.2	0.2	1.5
Impedance of leg (right)	0.5	2.3	4.2	2.0	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	-0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	1.5	-0.3
Medication: Atenolol	0.5	0.6	1.0	-1.0	0.4
Noisy workplace	0.5	0.6	0.8	0.9	0.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-1.1	-0.1
Breastfed as a baby	0.5	0.6	1.2	-1.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.2	0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	0.7	0.8	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	-0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.5	0.9	0.4	1.0
Comparative height size at age 10	0.5	2.9	3.7	1.4	1.9
Suffer from ‘nerves’	0.5	0.8	1.0	0.8	-1.0
Average weekly red wine intake	0.5	0.8	0.9	-1.0	-0.8
Ever smoked	0.5	0.8	1.6	-0.1	-1.3
Average weekly beer plus cider intake	0.5	0.7	1.2	0.4	-1.1
Alcohol drinker status: Previous	0.5	0.5	0.9	-0.4	-0.9
Schizophrenia (2018)	0.4	0.9	1.3	1.1	0.8
Age at First Birth	0.4	0.6	1.2	0.2	1.1
Systolic blood pressure, automated reading	0.4	1.1	1.9	-1.4	0.5
Medication: Metformin	0.4	0.6	1.0	0.4	-1.0
Impedance of leg (left)	0.4	2.0	4.0	2.0	-0.1
Diabetes (self-reported)	0.4	0.7	0.8	0.9	-0.7
Alcohol intake versus 10 years previously	0.4	0.6	0.7	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.4	1.0	2.0	1.4	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	0.3	1.0
Birth weight	0.4	0.9	1.0	-1.0	0.9
Angina (self-reported)	0.4	0.5	0.8	-0.9	-0.6
Mineral and other dietary supplements	0.4	0.5	0.8	-0.9	0.5
Osteoarthritis (self-reported)	0.4	0.5	0.6	0.8	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	1.0	-0.1
Unable to work because of sickness or disability	0.4	0.6	0.9	-0.9	-0.5
Depression (Nagel 2018)	0.3	0.5	0.9	0.2	-1.0
Lung FEV1/FVC ratio	0.3	1.4	2.4	1.6	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.4	-0.6	-0.6
Angina	0.3	0.3	0.5	-0.7	-0.4
Medication for hormone replacement therapy	0.3	0.3	0.7	0.1	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.0	-0.2	1.0
Alcohol usually taken with meals	0.3	0.5	0.9	-0.9	-0.2
Mouth/teeth dental problems	0.3	0.4	0.8	-0.3	0.9
Time employed in main current job	0.3	0.3	0.6	-0.0	0.8
Pulse rate	0.3	0.6	0.9	-0.5	0.9
Pulse wave reflection index	0.3	0.3	0.7	-0.8	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.4	0.8
Age at first live birth	0.3	0.6	1.1	0.3	1.1
Qualifications: College or University degree	0.3	0.9	1.7	1.3	-0.3
Pulse rate, automated reading	0.3	0.9	1.0	-0.9	1.0
Family relationship satisfaction	0.3	0.3	0.3	-0.5	-0.6
Supplements: Vitamin C	0.3	0.3	0.3	0.5	0.5
Ever had bowel cancer screening	0.3	0.4	0.4	-0.7	-0.5
Ever taken oral contraceptive pill	0.3	0.4	0.4	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.8	-0.3
Alcohol drinker status: Never	0.3	0.3	0.5	-0.7	0.4
Age started oral contraceptive pill	0.3	0.4	0.6	-0.4	0.8
Supplements: Calcium	0.3	0.3	0.6	0.7	0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.7	0.1
Schizophrenia (2014)	0.2	0.5	0.9	0.3	0.9
Systolic Blood Pressure	0.2	1.1	2.0	0.4	1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.6	0.2
Medication: Co-codamol	0.2	0.3	0.3	-0.5	-0.5
Diabetes (father)	0.2	0.2	0.4	0.7	0.0
Hand grip strength (right)	0.2	0.5	0.9	-0.9	-0.3
Current tobacco smoking	0.2	0.4	0.6	0.4	-0.8
Taking other prescription medications	0.2	0.3	0.6	0.3	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	0.0
Qualifications: None of the above	0.2	0.4	0.4	-0.6	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.8	-0.0
Depression (self-reported)	0.2	0.2	0.4	0.6	0.1
Birth weight of first child	0.2	0.4	0.5	-0.7	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	0.1	1.0
Heart disease (mother)	0.2	0.3	0.6	0.0	-0.8
Age at last live birth	0.2	0.3	0.4	-0.3	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.2	0.5	-0.4
Back pain experienced in last month	0.2	0.2	0.3	0.4	-0.5
Breast cancer (self-reported)	0.2	0.3	0.6	0.1	0.8
Smoking status: Current	0.2	0.3	0.3	0.6	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.2	0.4	0.5
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.2	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.7	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	-0.1
Ovarian Cancer	0.1	0.1	0.2	0.5	0.1
Fasting Glucose	0.1	0.1	0.2	-0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.2	-0.4	-0.4
Chronotype (morning person)	0.1	0.3	0.3	-0.5	0.5
Hair Pigment	0.1	1.7	2.2	1.5	1.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.1	-0.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.2	0.3
High blood pressure (mother)	0.1	0.1	0.2	-0.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.2	0.3
Exposure to tobacco smoke at home	0.1	0.2	0.3	-0.5	0.2
Gout (self-reported)	0.1	0.2	0.3	0.5	-0.3
Medication: Blood pressure	0.1	0.2	0.2	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.0	0.5
Financial situation satisfaction	0.1	0.1	0.1	-0.3	0.3
Number of operations (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.1	0.1	-0.3	-0.3
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	-0.1
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.1	0.3
Multivitamins +/- minerals	0.0	0.0	0.0	0.0	0.2
Sitting height	0.0	0.1	0.2	-0.2	0.4
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.2	0.2
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.2	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.1	0.3
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	-0.3
Wears glasses or contact lenses	0.0	0.0	0.1	0.2	-0.1
Mother’s age at death	0.0	0.0	0.0	-0.1	0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.2	0.1

Hub : Genes

MIR4519

Models

Trait associations