Hub : Genes

ITGAX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0250	1.3e-03	0.032	0.017	0.054	0.022	0.052	7.2e-05	3.4e-03	3.9e-07	8.4e-04	5.4e-07
2	GTEx	Testis	0.0790	0.0390	5.6e-03	0.025	NA	0.002	NA	0.007	2.7e-02	NA	2.5e-01	NA	1.5e-01
3	GTEx	Whole Blood	0.0840	0.0260	2.5e-07	0.097	NA	0.102	NA	0.106	3.3e-09	NA	1.3e-09	NA	5.3e-10
4	NTR	Blood	0.0636	0.0190	0.0e+00	0.071	0.071	0.080	0.076	0.077	8.1e-22	7.0e-22	1.4e-24	1.8e-23	1.2e-23
5	YFS	Blood	0.3020	0.0418	0.0e+00	0.383	0.393	0.413	0.407	0.415	1.3e-134	4.6e-139	2.4e-148	1.0e-145	4.1e-149
6	TCGA	Breast Invasive Carcinoma	0.0265	0.0143	3.0e-04	0.018	0.010	0.008	NA	0.014	9.5e-05	3.2e-03	8.8e-03	NA	5.3e-04
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0628	0.0320	1.4e-03	0.004	0.012	0.019	NA	0.006	1.1e-01	1.3e-02	3.1e-03	NA	6.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.1	-0.9	-0.7	-0.8	-1.1	-1.0	0.8	1.4
Bipolar Disorder or Schizophrenia	0.2	0.5	2.0	1.4	0.6	0.5	-0.2	0.3	-0.4	0.7
Depressed Affect (Nagel 2018)	0.1	0.2	1.0	-0.5	0.0	0.0	-0.2	-0.3	0.1	1.0
Depression (Nagel 2018)	0.1	0.1	0.6	-0.7	-0.3	-0.0	0.1	0.2	-0.2	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.8	-0.7	-0.3	-0.4	0.5	-0.0	0.4	-1.7
Neuroticism (Nagel 2018)	1.6	3.7	5.6	0.8	2.2	2.4	2.2	1.9	-2.1	-1.4
Schizophrenia (2018)	1.0	2.0	7.0	2.6	1.3	1.3	0.7	1.3	-1.2	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	1.2	0.6	0.4	0.7	0.4	-0.2	-1.3
Worry (Nagel 2018)	3.3	7.0	10.5	0.9	3.1	3.2	3.0	2.3	-2.6	-2.7
Alzheimer’s Disease (in mother)	2.6	3.0	4.1	1.7	2.0	1.9	1.9	1.9	-1.7	-0.7
Alzheimer’s Disease (in father)	0.8	0.8	2.9	1.7	0.6	0.5	1.1	0.6	-0.3	-0.9
Alzheimer’s Disease (including proxy)	4.7	6.9	9.5	3.1	3.0	2.7	3.0	2.7	-2.4	-0.7
Crohns Disease (2017)	0.3	0.7	1.9	0.1	1.4	1.2	0.8	0.7	-0.6	0.6
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	0.8	1.1	1.0	1.1	0.5	-0.1	0.0
Ulcerative Colitis (UC)	0.3	0.6	2.3	1.5	0.5	0.5	0.9	0.2	0.3	-0.4
Major Depression (MDD)	0.7	0.8	1.7	0.6	-0.7	-0.8	-0.7	-0.9	1.3	1.1
Reaction Time	0.1	0.2	0.3	-0.2	0.5	0.4	-0.6	-0.4	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.3	-1.4	-1.1	-1.0	-0.3	-0.8	1.0	-1.8
Breast Cancer	1.4	3.3	5.1	-1.6	-2.1	-2.1	-2.2	-2.3	1.2	0.8
Ovarian Cancer	0.2	0.2	0.4	0.7	0.4	0.6	0.5	0.3	-0.3	-0.6
Prostate Cancer	2.6	3.7	4.7	2.2	2.0	2.0	1.7	2.0	-1.6	-1.8
Age at First Birth	0.2	0.3	1.6	1.3	-0.0	-0.1	0.1	-0.1	-0.1	0.7
Bipolar Disorder (2011)	0.4	0.4	1.2	1.1	0.2	0.2	-0.1	0.1	-0.3	1.1
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	-1.4	-1.2	-1.1	-1.1	-0.8	0.4	1.4
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.8	-0.4	-0.4	0.1	-0.2	0.6	0.4
Crohns Disease (2012)	0.7	1.1	2.3	1.1	1.5	1.5	0.9	1.0	-0.6	0.3
Mean Putamen Volume	1.6	1.8	2.6	-1.2	-1.6	-1.6	-1.1	-1.3	1.2	1.3
Fasting Glucose	2.0	2.4	4.6	-0.9	-2.1	-1.9	-1.3	-1.8	1.7	0.0
HbA1C	0.1	0.1	0.5	0.7	0.1	0.1	-0.3	0.2	0.2	-0.6
HDL Cholesterol	0.3	0.4	1.0	1.0	1.0	0.6	0.7	0.3	0.2	-0.4
LDL Cholesterol	0.8	1.3	4.4	-0.5	0.9	1.0	0.4	0.9	-1.2	-2.1
Lupus	5.7	8.7	39.4	-1.2	2.3	2.5	0.8	2.7	-6.3	0.4
Neuroticism (2016)	1.3	1.8	2.8	1.3	1.6	1.7	1.2	1.5	-1.3	-0.3
Primary Biliary Cirrhosis	1.9	2.7	4.3	-2.0	-1.6	-1.8	-2.1	-1.8	1.0	0.6
Rheumatoid Arthritis	0.7	1.0	1.8	1.4	1.1	1.1	1.1	0.8	-0.7	0.1
Schizophrenia (2014)	0.3	0.6	3.2	1.8	0.5	0.6	0.4	0.6	-0.6	0.2
Triglycerides	2.9	4.8	8.0	-2.2	-2.3	-2.1	-2.8	-2.1	2.1	1.3
Type 2 Diabetes (T2D) (2012)	2.2	2.5	9.7	0.1	-1.5	-1.3	-1.4	-1.1	0.8	3.1
Ulcerative Colitis	0.3	0.5	0.9	0.9	0.5	0.4	1.0	0.2	0.5	-0.9
Blood Eosinophil Count	0.2	1.4	7.9	2.8	0.5	0.1	-0.2	0.0	0.8	0.8
Blood Platelet Count	0.8	8.8	46.0	-6.8	-1.6	-1.7	-1.1	-2.1	1.5	-1.5
Blood Red Count	2.0	19.5	30.7	3.9	5.4	5.0	5.5	3.7	-3.6	-3.0
Blood White Count	0.2	1.3	2.9	-0.8	-0.4	-0.7	-1.7	-1.5	1.7	0.5
Heel T-Score	0.4	3.3	7.0	2.6	1.7	1.9	2.1	2.0	-0.9	0.1
BMI	3.5	20.4	41.0	-6.4	-4.6	-4.7	-4.7	-4.6	3.9	0.3
Height	0.2	3.0	5.6	0.2	-2.4	-2.2	-2.1	-1.4	1.3	1.8
Waist Hip Ratio (WHR)	2.2	10.0	14.8	3.8	3.6	3.7	2.4	3.4	-3.4	0.3
Systolic Blood Pressure	0.3	1.5	7.8	-2.8	0.1	0.2	0.5	-0.3	-0.0	-1.4
Smoking Status	5.4	12.9	19.3	-2.7	-4.4	-4.4	-3.3	-3.7	4.1	1.5
Allergy or Eczema	0.2	0.5	2.0	1.4	1.0	0.8	0.3	0.1	-0.0	0.0
Cardiovascular Disease	1.8	6.0	10.1	-3.2	-3.0	-2.6	-2.2	-2.3	2.2	1.1
Hypothyroidism (self reported)	1.7	4.0	6.3	2.3	2.0	2.3	1.9	1.8	-2.5	0.4
Respiratory disease	0.2	0.4	1.6	1.3	0.5	0.6	-0.1	0.4	0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.2	-0.3	-0.7	-0.6	-1.1	-0.7	0.4	0.6
Lung FEV1/FVC ratio	0.2	1.0	5.5	-0.6	-0.3	-0.4	0.5	-0.4	0.5	-2.3
Lung FVC	2.9	14.8	22.8	3.0	4.2	4.3	4.8	4.0	-3.6	-2.6
Neuroticism	0.4	1.1	2.1	-0.3	1.5	1.4	1.0	0.5	-1.1	-0.9
Chronotype (morning person)	0.2	0.4	2.5	-0.5	0.1	0.0	0.4	-0.0	0.1	-1.6
Hair Pigment	0.0	1.2	4.6	1.1	0.9	1.0	0.2	0.8	-0.4	2.1
Tanning	0.1	1.2	4.2	0.2	1.0	0.7	0.8	1.0	-1.1	-2.1
Hand grip strength (left)	1.9	4.9	7.6	-2.3	-2.5	-2.8	-1.9	-2.5	2.3	-0.4
Number of treatments/medications taken	0.8	1.5	2.8	-0.6	-1.5	-1.2	-1.7	-1.1	1.2	1.0
Average weekly spirits intake	0.8	1.0	3.4	-0.1	-0.7	-0.7	-0.9	-1.0	0.9	1.8
Sensitivity / hurt feelings	0.9	1.6	2.7	-0.6	1.3	1.4	1.7	1.4	-1.3	-1.0
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.5	-1.2	-0.3	-0.1	-0.0	0.0	-0.0	-0.2
Hearing difficulty/problems: Yes	4.1	6.3	8.3	-2.6	-2.4	-2.5	-2.9	-2.6	2.2	2.3
Relative age of first facial hair	1.9	4.0	6.9	-0.9	-2.6	-2.4	-1.8	-1.6	1.6	2.4
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.6	1.6	1.4	1.6	1.1	1.5	-1.6	0.5
Ever used hormone-replacement therapy (HRT)	2.1	2.7	5.3	0.9	1.4	1.5	1.7	2.2	-2.3	-0.9
Ever had hysterectomy (womb removed)	0.3	0.4	1.5	-1.2	-0.6	-0.7	-0.2	-0.3	-0.0	-0.3
Systolic blood pressure, automated reading	0.6	1.6	9.9	-3.1	-0.3	-0.5	-0.1	-0.8	0.0	-0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.8	0.6	0.9	0.9	0.7	1.0	-0.5	-1.3
Angina	0.4	0.5	1.6	-1.1	-0.4	0.1	0.1	0.0	-0.5	1.3
Medication for hormone replacement therapy	0.5	0.6	1.5	1.2	0.5	0.6	0.6	1.2	-0.4	-0.2
Vitamin and mineral supplements	1.2	1.6	3.5	1.1	1.3	1.5	0.7	0.9	-1.9	-1.1
Supplements: Zinc	0.1	0.2	0.3	0.1	0.5	0.4	0.6	0.3	-0.2	-0.4
Medication: Co-codamol	0.3	0.4	1.1	0.1	0.6	0.4	0.4	0.8	-1.1	0.4
Medication: Metformin	1.3	1.9	3.0	0.6	-1.3	-1.3	-1.7	-1.7	1.6	1.2
Diabetes (father)	0.2	0.3	0.5	-0.5	-0.1	-0.4	-0.6	-0.7	0.6	-0.5
Diabetes (mother)	0.4	0.5	3.1	-1.8	-0.3	-0.2	-0.3	-0.5	0.1	-0.3
Severe depression (siblings)	5.0	5.6	8.8	0.8	3.0	2.9	2.2	2.7	-2.8	-1.1
Pack years adult smoking proportion	1.4	2.1	3.0	-1.1	-1.7	-1.6	-1.6	-1.4	1.2	1.3
Impedance of leg (right)	2.0	9.6	24.0	4.9	2.9	3.0	2.5	3.2	-2.6	1.7
Leg fat-free mass (left)	2.7	14.0	26.1	-5.1	-4.0	-4.1	-3.7	-3.9	3.1	0.1
Trunk fat percentage	3.1	12.3	18.8	-3.4	-4.0	-3.9	-4.3	-3.5	2.9	2.0
Hand grip strength (right)	1.6	4.3	6.2	-2.1	-2.4	-2.5	-1.5	-2.4	2.5	-0.2
Townsend deprivation index at recruitment	0.6	0.8	2.6	-1.6	-0.6	-0.6	-1.2	-0.4	0.7	0.4
Current tobacco smoking	0.6	0.9	2.0	-1.1	-0.9	-0.9	-0.7	-0.9	1.4	-0.3
Average weekly fortified wine intake	0.9	1.1	2.2	-1.3	-0.4	-0.5	-1.1	-1.0	0.8	1.5
Maternal smoking around birth	1.1	1.5	2.6	-1.1	-1.2	-1.4	-1.0	-1.4	1.6	0.6
Fed-up feelings	0.5	0.9	2.7	-1.6	-0.8	-0.8	-1.1	-0.6	1.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	-0.8	0.1	0.3	0.1	0.3	-0.6	-0.6
Relative age voice broke	3.5	5.4	8.5	-0.8	-2.8	-2.9	-2.6	-2.1	1.5	2.7
Taking other prescription medications	0.3	0.5	1.6	1.3	-0.5	-0.1	-0.7	0.1	0.2	0.9
Age when periods started (menarche)	0.1	0.2	0.9	-0.6	-0.1	-0.2	-0.3	-0.9	0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.9	-0.3	-0.3	0.1	-0.2	0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.1	1.5	0.4	0.4	0.7	0.7	0.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.2	-0.4	0.2	0.2
Qualifications: CSEs or equivalent	2.7	3.6	4.8	-1.6	-2.1	-2.2	-1.7	-1.7	2.0	1.9
Serious illness, injury or assault to yourself	1.2	1.5	2.3	0.5	1.3	1.3	0.9	1.3	-1.4	-1.5
High blood pressure	1.5	4.3	8.8	-3.0	-2.3	-2.0	-2.0	-2.0	1.5	1.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.7	1.3	1.2	1.1	0.7	0.6	-0.3	0.2
Multivitamins +/- minerals	1.7	2.1	4.8	-1.4	-1.5	-1.7	-1.0	-1.2	2.2	0.5
Stomach or abdominal pain in last month	2.2	2.8	3.6	0.6	1.7	1.9	1.8	1.9	-1.7	-1.8
Supplements: Glucosamine	0.6	0.8	1.8	0.6	0.6	0.8	1.3	1.3	-0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.3	-0.8	-1.1	-1.0	-0.8	-0.8	0.8	2.1
Medication: Atenolol	0.0	0.1	0.4	-0.6	-0.2	-0.1	-0.0	-0.0	-0.0	0.0
Medication: Levothyroxine sodium	0.7	1.1	3.7	1.9	0.5	0.8	0.6	0.6	-1.1	1.1
Sitting height	0.4	2.6	5.0	-0.6	1.6	1.3	1.8	1.5	-2.2	-1.7
Chronic bronchitis/emphysema (father)	1.6	1.9	3.2	-0.6	-1.7	-1.8	-1.6	-1.3	1.4	0.7
High blood pressure (mother)	0.6	0.8	5.0	-2.2	0.4	0.3	0.0	0.0	-0.5	-0.6
Body mass index (BMI)	5.7	24.3	38.5	-6.2	-5.3	-5.4	-5.2	-5.2	4.4	1.2
Impedance of leg (left)	1.9	9.3	21.9	4.7	2.9	3.1	2.6	3.2	-2.7	1.0
Leg predicted mass (left)	2.8	14.7	26.7	-5.2	-4.1	-4.2	-3.8	-4.0	3.2	0.1
Trunk fat mass	3.5	14.9	20.6	-4.2	-4.3	-4.3	-4.5	-4.0	3.2	1.7
Waist circumference	4.1	15.1	22.3	-4.2	-4.2	-4.3	-4.7	-4.2	3.1	1.6
Number of incorrect matches in round	5.0	8.2	11.0	2.8	3.2	3.3	2.7	2.8	-3.3	-1.5
Past tobacco smoking	5.8	10.6	14.3	2.7	3.8	3.8	3.3	3.4	-3.8	-1.4
Alcohol usually taken with meals	0.1	0.2	0.5	-0.4	0.5	0.4	0.1	0.1	-0.7	0.0
Nervous feelings	1.5	2.8	4.8	0.8	2.2	2.0	2.0	1.5	-1.4	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	-0.7	0.6	0.6	0.8	0.5	-0.2	-1.4
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-1.1	-0.8	-0.7	-1.1	-0.7	0.4	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.5	0.4	0.5	0.6	0.3	-0.9	-0.4
Had menopause	2.3	2.8	4.7	-1.5	-1.6	-1.6	-2.0	-1.7	0.8	2.2
Had other major operations	0.5	0.7	1.9	-0.4	-1.4	-1.1	-0.2	-0.6	0.6	0.7
Forced vital capacity (FVC)	3.4	13.2	21.2	3.1	3.8	3.9	4.6	3.7	-3.9	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	1.3	0.1	0.1	0.4	0.3	0.5	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-0.2	1.0	1.0	1.2	0.9	-0.5	-0.7
Qualifications: None of the above	1.6	3.4	6.7	-0.1	-1.4	-1.7	-2.0	-2.0	2.0	2.6
Financial difficulties in last 2 years	1.5	2.0	3.3	-0.9	-1.5	-1.7	-1.8	-1.4	1.6	0.6
Mouth/teeth dental problems	1.2	1.8	2.8	0.2	1.6	1.4	1.1	1.4	-1.7	-1.5
Heart attack	0.3	0.4	2.0	-0.3	-0.4	-0.3	-0.4	-0.2	0.1	1.4
Allergy	0.3	0.7	1.9	-0.9	0.4	0.6	0.9	0.7	-1.4	-0.8
Pain all over the body in last month	3.7	4.0	6.0	-1.7	-2.5	-2.2	-1.8	-2.0	2.4	1.0
Diabetes (self-reported)	0.4	0.6	1.4	0.2	-0.9	-0.6	-0.9	-0.8	1.2	0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	6.0	2.4	1.2	1.5	0.8	1.0	-1.0	0.6
Medication: Ramipril	3.8	4.8	7.1	-1.3	-2.4	-2.2	-2.1	-2.4	2.0	2.7
Medication: Simvastatin	2.8	4.1	5.2	-1.7	-2.3	-2.1	-2.2	-1.9	2.0	2.0
Fluid intelligence score	1.2	2.4	7.2	-2.7	-1.5	-1.6	-0.8	-1.1	1.3	-1.3
Illnesses of siblings	8.5	11.9	15.1	3.9	3.6	3.7	3.5	3.7	-3.8	-1.2
Neuroticism score	0.6	1.3	2.5	-0.3	1.6	1.5	1.1	0.9	-1.2	-1.0
Weight	4.0	19.9	29.9	-5.5	-4.9	-4.9	-4.8	-4.7	3.7	1.1
Impedance of arm (right)	3.2	15.0	34.2	5.8	3.7	3.9	3.4	4.2	-3.7	-0.2
Arm fat percentage (right)	3.9	15.3	20.5	-4.4	-4.4	-4.3	-4.5	-4.1	3.3	1.4
Trunk fat-free mass	1.3	7.2	18.0	-4.2	-2.7	-2.9	-2.4	-2.8	1.8	-0.2
Hip circumference	6.3	27.1	37.7	-6.1	-5.9	-5.9	-5.6	-5.5	4.5	0.9
Time employed in main current job	0.8	1.0	3.4	1.3	0.6	0.7	0.2	0.6	-0.8	1.8
Alcohol intake versus 10 years previously	0.4	0.6	1.5	1.2	0.1	0.1	-0.2	0.9	-0.2	-1.2
Father’s age at death	2.8	3.7	4.9	1.3	2.2	1.9	2.1	2.1	-1.7	-1.9
Worrier / anxious feelings	4.0	7.5	12.0	0.9	3.4	3.5	2.9	2.8	-2.9	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.4	-1.8	-1.0	-1.0	-0.8	-0.8	0.8	0.1
Falls in the last year	0.3	0.4	1.8	-1.3	-0.2	-0.1	-0.9	-0.4	-0.1	0.3
Hair/balding pattern: Pattern 3	1.3	1.9	2.8	-1.5	-1.7	-1.5	-1.5	-1.4	1.3	-0.5
Number of live births	4.3	6.0	8.3	-2.2	-2.5	-2.6	-2.9	-2.7	2.1	2.1
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	16.9	2.6	3.1	3.1	4.1	3.1	-3.1	-1.7
Pulse rate	0.1	0.3	1.6	1.3	-0.1	-0.2	-0.2	-0.2	0.0	-0.2
Happiness	0.8	0.9	2.8	1.0	0.8	0.7	0.9	0.6	-0.5	-1.7
Noisy workplace	0.3	0.3	0.6	0.4	0.5	0.7	0.8	0.6	-0.7	-0.4
Qualifications: A levels/AS levels or equivalent	1.3	2.9	4.8	1.7	1.4	1.5	2.2	2.1	-0.9	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.2	0.9	1.0	1.3	1.4	-1.2	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.7	0.1	0.5	0.7	0.4	0.5	-0.7	1.3
Asthma	0.4	0.8	1.7	0.7	-0.9	-0.8	-0.8	-0.6	1.3	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.5	-0.1	-1.0	-1.0	-1.2	-0.7	0.8	0.1
Medication: Cholesterol lowering	0.8	1.2	2.7	-1.0	-1.1	-0.8	-1.6	-1.0	0.7	1.0
Depression (self-reported)	0.3	0.4	1.9	-1.4	0.2	0.3	0.1	-0.0	-0.0	-0.7
Medication: Lansoprazole	0.3	0.3	0.5	-0.0	0.5	0.6	0.7	0.7	-0.7	-0.3
Prospective memory result	3.8	4.6	8.4	2.5	2.9	2.7	1.6	1.7	-2.0	-0.9
Lung cancer (father)	0.2	0.2	0.5	-0.1	0.4	0.5	0.2	0.0	-0.5	-0.7
Illnesses of mother	0.5	0.6	2.3	1.5	0.6	0.7	0.4	0.4	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	12.8	2.8	3.1	3.1	3.6	2.8	-3.1	-0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.6	0.1	0.0	-0.2	0.2	-0.2	0.3
Impedance of arm (left)	2.7	12.3	32.7	5.7	3.2	3.5	2.9	3.6	-3.2	0.6
Arm fat mass (right)	4.4	18.1	28.9	-5.4	-4.7	-4.7	-4.6	-4.4	3.6	1.0
Trunk predicted mass	1.3	7.4	17.6	-4.2	-2.8	-3.0	-2.5	-2.8	1.9	-0.2
Standing height	0.1	0.6	1.7	0.9	0.7	0.6	0.6	0.7	-1.3	-0.4
Length of working week for main job	1.0	1.1	2.5	-1.1	-0.7	-0.7	-0.9	-1.2	0.9	1.6
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.9	-0.2	-0.1	-0.3	0.0	-0.6	-0.4
Breastfed as a baby	0.8	1.0	3.1	0.4	-1.3	-0.7	-1.2	-0.2	-0.0	1.8
Tense / ‘highly strung’	0.5	0.8	1.5	0.4	1.1	1.2	1.2	0.5	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.7	0.9	1.0	0.3	0.4	-0.8	-0.0
Hair/balding pattern: Pattern 4	0.6	1.5	2.6	1.5	1.6	1.4	1.1	1.3	-0.7	-0.2
Birth weight of first child	0.6	1.2	2.6	-1.6	-0.8	-0.8	-0.8	-1.0	1.0	-1.3
Peak expiratory flow (PEF)	0.3	0.7	2.4	0.6	0.5	0.4	1.6	0.5	-0.2	-1.1
Pulse wave reflection index	0.1	0.2	0.4	-0.6	-0.2	-0.3	-0.6	-0.2	0.3	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	0.6	0.7	0.6	1.0	1.0	-0.5	-0.9
Loud music exposure frequency	0.4	0.5	1.1	-1.0	-0.8	-0.8	-0.5	-0.6	0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.7	0.5	0.5	0.9	1.0	-0.5	-0.9
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	5.2	-0.3	-2.1	-2.0	-1.9	-1.9	2.3	0.7
Blood clot in the leg (DVT)	0.4	0.5	0.9	-0.6	-0.9	-0.9	-0.8	-0.8	0.4	0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.0	-0.4	-0.3	-0.7	0.2	-0.2	0.6
Headache pain in last month	0.3	0.5	1.6	-1.0	-0.6	-0.5	-0.2	-0.1	0.2	-1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.8	0.7	0.4	0.4	0.6	-0.3	0.7
Glaucoma (self-reported)	1.3	1.5	4.4	2.1	1.1	1.3	1.1	1.1	-0.9	0.3
Gout (self-reported)	0.6	0.8	1.7	1.3	0.8	0.9	0.6	1.0	-1.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.7	2.2	0.8	1.0	0.5	0.7	-1.3	0.6
Medication: Amlodipine	0.4	0.5	1.3	1.1	-0.3	-0.4	-0.3	-0.5	1.1	0.6
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.3	0.1	0.2	0.0	0.2	0.1	-0.3
Birth weight	2.5	5.4	10.3	-3.2	-2.5	-2.4	-1.9	-2.2	2.1	1.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.3	-0.3	-0.2	-0.6	-0.1	0.7	0.4
High blood pressure (siblings)	6.0	8.6	13.5	-3.7	-3.0	-3.2	-2.9	-3.1	3.0	1.0
Forced vital capacity (FVC), Best measure	2.6	9.6	14.3	3.2	3.3	3.4	3.8	3.0	-3.4	-0.7
Body fat percentage	4.0	15.9	22.8	-4.0	-4.5	-4.4	-4.8	-4.1	3.4	2.3
Leg fat percentage (right)	5.1	18.5	23.8	-4.1	-4.7	-4.7	-4.9	-4.6	3.9	2.8
Arm fat-free mass (right)	3.0	15.2	29.6	-5.4	-4.1	-4.2	-3.8	-4.1	3.2	0.7
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.0	-0.3	-0.3	0.2	0.2	0.2	-0.6
Comparative body size at age 10	5.4	14.8	19.0	-3.6	-4.4	-4.2	-4.2	-4.0	4.2	1.6
Number of full brothers	2.1	2.6	4.6	-1.3	-2.1	-2.0	-1.7	-1.3	1.5	0.9
Worry too long after embarrassment	0.5	0.8	1.3	0.4	1.0	1.0	1.1	0.7	-0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.6	1.1	1.1	0.2	0.4	-0.7	0.1
Wheeze or whistling in the chest in last year	2.1	3.7	4.8	-1.9	-1.8	-1.7	-2.2	-1.8	2.0	1.9
Number of children fathered	1.8	2.0	3.8	-2.0	-1.5	-1.7	-1.2	-1.5	1.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	5.6	-0.5	0.2	0.1	-0.2	-0.3	-0.5	2.4
Age at first live birth	1.9	3.3	4.6	2.1	1.9	2.0	1.7	1.9	-2.1	0.3
Pulse wave peak to peak time	0.1	0.1	0.3	-0.5	-0.1	-0.0	0.2	-0.2	0.1	-0.3
Health satisfaction	0.2	0.2	0.3	-0.5	-0.6	-0.6	-0.3	-0.4	-0.1	0.4
Shortness of breath walking on level ground	1.7	2.1	5.3	-0.6	-1.1	-1.4	-1.6	-1.3	1.2	2.3
Qualifications: College or University degree	1.1	3.5	6.3	1.3	1.6	1.9	2.5	2.2	-1.8	-1.6
Eye problems/disorders: None of the above	0.5	0.6	1.9	-1.4	-0.5	-0.6	0.0	-0.5	0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.6	-0.1	-0.2	0.0	-0.2	-0.0	-0.3	1.2
Emphysema/chronic bronchitis	0.8	0.9	2.0	0.0	-0.7	-0.8	-1.4	-1.0	0.8	1.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.3	-0.1	-0.3	0.2	-0.8	0.7	-0.3
Neck or shoulder pain in last month	0.2	0.3	1.6	-1.3	-0.6	-0.2	-0.3	-0.3	0.1	0.2
Medication: Blood pressure	0.2	0.4	0.7	-0.8	-0.9	-0.5	-0.2	-0.6	0.2	-0.5
Angina (self-reported)	0.4	0.6	2.2	-1.1	-0.6	-0.2	-0.2	-0.3	-0.2	1.5
Migraine (self-reported)	0.1	0.1	0.2	0.3	0.2	0.3	0.3	0.2	-0.3	0.4
Medication: Ibuprofen	1.3	1.6	2.7	-0.6	-1.4	-1.4	-1.6	-1.2	1.3	0.8
Medication: Allopurinol	2.3	3.1	5.9	2.4	2.0	2.0	1.3	1.8	-1.6	-0.3
Medication: Omeprazole	2.3	2.7	3.9	0.5	1.6	1.8	1.6	1.9	-2.0	-1.6
Medication: Seretide 50 evohaler	1.0	1.2	2.8	1.7	1.1	1.3	0.7	1.3	-0.6	-0.2
Mean time to correctly identify matches	0.2	0.4	0.7	0.8	0.7	0.7	-0.5	-0.3	-0.0	0.8
Heart disease (mother)	0.4	0.4	0.9	-0.1	0.3	0.7	0.9	0.9	-0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.8	-0.9	-1.1	-1.3	-0.8	1.1	-0.1
Whole body fat mass	4.3	17.8	22.8	-4.7	-4.7	-4.6	-4.8	-4.4	3.7	1.8
Leg fat mass (right)	5.8	22.7	28.6	-5.3	-5.2	-5.2	-5.2	-5.1	4.4	2.1
Arm predicted mass (right)	3.2	16.5	30.9	-5.6	-4.2	-4.4	-4.0	-4.4	3.4	0.8
Pulse rate, automated reading	0.9	2.8	5.3	-1.2	-1.4	-1.6	-2.3	-2.1	1.9	-0.2
Alcohol intake frequency.	1.2	2.7	4.0	-1.9	-1.4	-1.7	-2.0	-1.9	1.7	0.2
Comparative height size at age 10	0.3	1.6	3.5	1.9	1.2	1.1	0.7	1.7	-1.2	0.4
Number of full sisters	0.8	1.0	4.3	-2.1	-0.7	-0.6	-1.1	-0.5	0.5	0.3
Suffer from ‘nerves’	0.5	0.8	1.4	-0.4	0.9	1.0	1.2	1.0	-1.1	-0.4
Overall health rating	0.6	1.3	3.0	-1.7	-1.4	-1.2	-1.2	-0.8	0.7	-0.3
Chest pain or discomfort	0.9	1.3	2.0	-1.4	-1.2	-1.2	-1.4	-1.0	0.9	0.9
Had major operations	0.4	0.4	1.1	0.5	0.5	0.5	0.0	0.5	-1.1	0.9
Age at last live birth	0.1	0.1	0.5	-0.0	0.3	0.4	0.1	0.0	-0.3	0.7
Family relationship satisfaction	0.4	0.5	2.2	-0.4	-0.5	-0.5	-0.6	-0.3	0.2	-1.5
Leg pain on walking	0.1	0.1	0.3	-0.5	0.1	0.2	-0.0	-0.4	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-1.3	-0.7	-0.6	-0.3	-0.5	0.2	-0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.5	-1.2	-0.9	-0.5	-0.5	-0.8	0.9	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.5	0.0	0.2	-0.0	-0.1	-0.5	0.1
Medication: Aspirin	0.8	1.1	2.1	-1.3	-1.2	-0.8	-1.0	-0.9	0.3	1.5
Supplements: Vitamin C	0.3	0.4	0.8	0.2	0.6	0.6	0.7	0.9	-0.7	0.4
Knee pain experienced in last month	2.3	3.6	7.0	-2.6	-2.2	-2.0	-1.9	-1.7	1.7	-0.2
Hypertension (Self-reported)	1.4	4.0	7.1	-2.7	-2.3	-2.0	-1.9	-2.0	1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.3	5.7	1.3	2.4	2.1	1.6	2.0	-1.6	-1.6
Illnesses of father: Heart disease	1.1	1.5	2.2	0.0	1.3	1.5	1.3	1.4	-1.0	-1.5
Illnesses of siblings: Diabetes	3.1	3.7	8.8	-1.7	-2.0	-1.8	-1.8	-1.8	3.0	1.1
Smoking status: Previous	7.5	11.2	15.8	-2.6	-4.0	-3.9	-3.3	-3.5	3.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-0.7	1.0	1.0	0.7	0.6	-1.1	-0.4
Whole body fat-free mass	1.9	10.9	24.5	-5.0	-3.4	-3.5	-3.1	-3.4	2.5	-0.2
Leg fat-free mass (right)	2.4	12.6	26.1	-5.1	-3.7	-3.8	-3.4	-3.7	2.9	-0.5
Arm fat percentage (left)	4.1	16.5	22.4	-4.4	-4.5	-4.4	-4.7	-4.3	3.5	1.9
Average weekly red wine intake	0.2	0.4	0.9	-0.4	0.6	0.5	0.9	0.4	-0.5	-0.7
Handedness (chirality/laterality): Left-handed	1.0	1.1	2.9	-1.7	-0.9	-0.8	-0.8	-1.0	1.2	-0.7
Mood swings	0.4	0.8	2.8	-0.6	-0.3	-0.4	-0.7	-0.7	0.9	1.7
Loneliness, isolation	0.1	0.1	0.4	-0.2	0.1	0.2	-0.1	0.1	-0.2	0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.7	0.0	0.3	0.2	0.7	-0.5	0.2
Ever had bowel cancer screening	0.9	1.1	1.3	-0.9	-1.1	-1.1	-1.0	-1.2	0.9	1.0
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.2	-0.9	-0.6	-0.9	-0.6	1.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	0.7	-0.0	0.0	0.2	0.1	0.5	0.6
Friendships satisfaction	0.5	0.6	2.0	1.0	-0.1	-0.1	0.7	0.2	0.6	-1.4
Qualifications: nursing, teaching	4.5	7.0	9.9	2.1	2.6	2.8	3.1	2.9	-2.6	-2.1
Commuting to job workplace: Walk	0.3	0.4	1.8	-0.0	0.2	-0.1	-0.7	-0.5	0.0	1.4
Eye problems/disorders: Cataract	0.1	0.1	0.5	0.4	-0.1	-0.1	-0.4	0.1	-0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.0	-0.7	-2.2	-2.1	-1.4	-1.6	1.8	0.9
Medication for cholesterol	1.7	2.6	3.3	1.4	1.8	1.8	1.6	1.4	-1.8	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.9	5.8	7.9	1.1	2.7	2.6	2.8	2.8	-2.2	-2.0
Back pain experienced in last month	0.3	0.4	1.1	0.5	-1.1	-0.7	-0.1	-0.2	0.9	-0.2
Mineral and other dietary supplements	0.2	0.3	0.8	-0.6	-0.4	-0.4	-0.7	-0.9	0.3	-0.0
Breast cancer (self-reported)	0.3	0.4	0.9	0.7	0.4	0.6	0.0	0.4	-0.9	0.8
Asthma (self-reported)	0.1	0.3	1.1	1.0	-0.3	-0.2	-0.3	-0.1	0.7	0.4
Osteoporosis (self-reported)	2.2	2.7	4.0	-0.0	-2.0	-1.9	-1.8	-1.6	1.4	1.8
Osteoarthritis (self-reported)	2.7	3.6	6.0	1.5	2.3	2.4	1.5	2.0	-2.3	0.1
Medication: Aspirin	0.7	0.8	2.4	-1.4	-0.8	-0.4	-0.7	-0.6	-0.2	1.5
Medication: Gliclazide	0.9	1.0	4.6	2.1	-0.0	-0.1	-0.2	-0.1	1.0	1.0
Illnesses of father: None of the above (group 1)	0.9	1.2	2.1	1.0	1.1	1.3	0.9	0.9	-1.5	0.7
Smoking status: Current	0.3	0.5	1.3	-0.8	-0.7	-0.7	-0.4	-0.6	1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.9	16.7	21.2	3.6	4.6	4.6	4.6	4.4	-4.3	-1.8
Whole body water mass	1.9	11.0	23.7	-4.9	-3.4	-3.6	-3.1	-3.5	2.5	-0.2
Leg predicted mass (right)	2.4	12.8	25.6	-5.1	-3.8	-3.9	-3.4	-3.8	2.9	-0.5
Arm fat mass (left)	4.5	18.7	26.5	-5.2	-4.8	-4.8	-4.8	-4.5	3.7	1.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.3	-0.5	-0.0	-0.7	-0.1	-0.3	0.9
Average weekly champagne plus white wine intake	2.3	3.2	12.0	-3.5	-1.5	-1.5	-1.4	-1.6	1.1	0.3
Miserableness	1.1	1.8	2.4	-1.6	-1.4	-1.4	-1.2	-1.5	1.5	0.8
Guilty feelings	0.2	0.3	1.4	-0.2	0.2	0.3	0.5	0.3	-0.4	-1.2
Wears glasses or contact lenses	2.6	3.0	5.1	-0.7	-2.0	-2.0	-1.7	-2.0	2.3	0.5
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.1	-0.8	-0.7	-0.6	-0.5	0.7	0.5
Hearing aid user	2.1	2.3	3.7	-1.7	-1.9	-1.9	-1.4	-1.5	1.4	-0.1
Mother’s age at death	0.3	0.4	1.0	1.0	0.7	0.6	0.2	0.2	-0.5	0.7
Financial situation satisfaction	0.4	0.5	0.8	-0.8	-0.4	-0.6	-0.2	-0.7	0.9	-0.8
Tinnitus: Yes, now most or all of the time	8.3	9.7	12.4	-2.2	-3.4	-3.4	-3.5	-3.5	3.2	2.3
Commuting to job workplace: Public transport	0.2	0.2	1.3	-0.1	-0.2	-0.3	-0.3	-0.1	-0.3	1.2
Eye problems/disorders: Glaucoma	1.2	1.5	2.9	1.7	1.3	1.3	0.9	1.3	-1.3	0.2
Medication: Blood pressure	2.5	4.7	5.5	-1.7	-2.3	-2.3	-2.2	-2.2	2.2	2.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.1	0.4	0.7	0.6	0.4	-0.4	-0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.7	0.9	1.2	1.1	1.3	1.3	-1.1	-1.1
High cholesterol (Self-reported)	1.5	2.7	3.7	-1.8	-1.8	-1.5	-1.9	-1.6	1.7	1.0
Medication: Bendroflumethiazide	0.9	1.4	4.6	-2.1	-1.1	-1.0	-0.7	-1.1	-0.0	0.9
Medication: Paracetamol	0.2	0.4	0.7	-0.8	-0.6	-0.7	-0.9	-0.4	0.2	0.3
Medication: Lisinopril	0.3	0.4	0.6	-0.7	-0.7	-0.7	-0.7	-0.7	0.4	0.4
Medication: Atorvastatin	0.4	0.5	1.5	-0.8	-0.6	-0.5	-1.2	-0.8	-0.1	0.1
Illnesses of father: High blood pressure	0.7	0.8	2.1	-1.4	-0.8	-0.9	-0.7	-0.9	0.8	0.7
Alcohol drinker status: Never	0.1	0.1	0.3	-0.3	0.3	-0.0	-0.2	-0.4	-0.2	0.6
Ever smoked	3.6	6.2	9.0	-2.3	-2.9	-2.9	-2.5	-2.5	3.0	0.9
Basal metabolic rate	2.4	13.5	25.9	-5.1	-3.9	-4.1	-3.7	-3.9	3.0	0.2
Leg fat percentage (left)	5.3	19.2	24.8	-4.5	-4.8	-4.7	-5.0	-4.7	4.0	2.5
Arm fat-free mass (left)	2.8	14.4	27.4	-5.2	-4.0	-4.2	-3.7	-4.0	3.1	0.4
Number of operations (self-reported)	0.1	0.2	0.3	0.6	-0.4	-0.1	0.5	0.3	-0.4	-0.6
Average weekly beer plus cider intake	0.3	0.4	1.0	0.9	0.2	0.3	1.0	0.7	-0.3	-0.7
Irritability	0.7	1.2	2.0	0.4	1.4	1.4	1.2	1.1	-0.9	-1.0
Risk taking	0.7	1.0	1.7	-0.5	-1.0	-0.9	-1.1	-1.3	1.2	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.1	1.5	0.9	0.9	1.0	1.1	-0.9	-0.7
Fractured/broken bones in last 5 years	3.6	4.6	6.7	-2.5	-2.5	-2.6	-2.5	-2.0	1.1	1.2
Age started oral contraceptive pill	0.2	0.2	0.6	-0.8	0.2	0.2	-0.2	0.1	-0.4	-0.7
Diastolic blood pressure, automated reading	1.7	5.3	9.3	-3.0	-2.6	-2.6	-2.3	-2.4	1.6	0.3
Ever depressed for a whole week	0.2	0.2	0.4	0.1	0.6	0.6	0.6	0.4	-0.2	0.2
Unable to work because of sickness or disability	0.5	0.7	3.2	-1.8	-0.3	-0.3	-0.9	-0.7	0.4	-0.2
Commuting to job workplace: Cycle	0.2	0.2	0.8	0.9	-0.2	-0.1	0.2	0.2	0.2	0.6
Myopia	2.3	3.4	5.8	0.1	-2.4	-2.3	-2.0	-1.9	2.1	0.9
Vascular/heart problems diagnosed by doctor	2.4	6.6	11.9	3.4	2.8	2.5	2.6	2.6	-1.8	-1.8
Cholesterol lowering medication	3.1	4.6	6.4	-2.2	-2.3	-2.2	-2.5	-2.0	1.6	2.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	2.9	0.6	1.7	1.6	1.3	1.7	-1.6	-1.6
Pain experienced in last month	1.4	2.4	4.8	1.3	2.2	1.8	1.6	1.3	-1.7	0.2
Supplements: Calcium	0.4	0.4	0.9	-0.9	-0.4	-0.5	-0.5	-0.6	0.7	-0.8
Basal cell carcinoma (self-reported)	1.0	1.2	4.7	-2.2	-0.7	-0.7	-0.6	-1.1	0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.1	-0.5	-0.4	-0.4	-0.4	-0.3	0.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.0	-0.9	-1.0	-1.0	-1.0	-1.0	0.5	0.3
Heart disease (siblings)	1.6	2.0	2.6	-1.6	-1.5	-1.5	-1.4	-1.6	1.3	0.7
Alcohol drinker status: Previous	1.3	1.5	3.9	-2.0	-0.9	-1.0	-0.9	-1.5	1.0	0.5
Pack years of smoking	2.1	3.1	3.9	-1.2	-2.0	-1.8	-2.0	-1.7	1.5	1.9
Impedance of whole body	2.6	13.3	33.9	5.8	3.4	3.6	3.1	3.8	-3.2	0.8
Leg fat mass (left)	5.7	22.4	30.8	-5.5	-5.1	-5.2	-5.2	-5.0	4.3	1.8
Arm predicted mass (left)	3.2	16.1	30.6	-5.5	-4.2	-4.4	-3.9	-4.2	3.4	0.3