TWAS hub - ITGAM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0650	0.0300	3.4e-03	0.026	NA	0.020	NA	0.023	1.8e-03	NA	5.6e-03	NA	3.3e-03
2	YFS	Blood	0.0959	0.0378	5.0e-11	0.045	0.044	0.054	0.059	0.043	2.0e-14	2.6e-14	2.9e-17	1.5e-18	5.1e-14
3	TCGA	Prostate Adenocarcinoma	0.0449	0.0324	5.4e-03	0.007	0.017	0.017	NA	0.014	6.1e-02	6.1e-03	6.1e-03	NA	1.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lupus	32.5	49.3	74.0	8.6	3.3	7.9
Smoking status: Previous	6.5	9.6	11.0	2.6	-3.3	-3.3
Tinnitus: Yes, now most or all of the time	5.9	6.9	8.2	2.8	-2.9	-2.1
Number of incorrect matches in round	5.8	9.6	11.4	-3.2	3.4	2.7
Past tobacco smoking	5.1	9.3	12.0	-2.4	3.2	3.5
Osteoporosis (self-reported)	4.7	5.8	10.4	3.2	-2.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.7	10.0	12.2	-3.5	3.3	2.6
Smoking Status	4.5	10.7	12.0	3.0	-3.3	-3.5
Pain all over the body in last month	4.4	4.7	7.8	0.8	-2.8	-2.4
Fractured/broken bones in last 5 years	4.4	5.6	15.6	4.0	-1.0	-0.6
Illnesses of siblings	4.3	6.0	8.1	-2.6	1.7	2.8
Worrier / anxious feelings	4.2	8.0	10.5	-2.5	3.2	2.7
Severe depression (siblings)	3.9	4.4	5.0	-2.1	1.9	2.2
Comparative body size at age 10	3.9	10.7	13.2	2.6	-3.6	-3.5
Hip circumference	3.8	16.4	29.6	5.4	-3.7	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	5.9	-2.4	2.1	1.7
Cholesterol lowering medication	3.6	5.3	10.4	3.2	-2.2	-0.8
High blood pressure (siblings)	3.5	5.1	7.1	2.7	-1.5	-2.4
Leg fat mass (right)	3.5	13.4	20.3	4.5	-3.4	-2.9
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	6.8	1.0	-2.6	-2.1
Leg fat mass (left)	3.2	12.5	18.9	4.3	-3.3	-2.8
Body mass index (BMI)	3.1	13.4	20.4	4.5	-3.5	-2.7
Number of live births	3.1	4.4	8.6	2.9	-1.3	-1.7
Prospective memory result	3.1	3.8	6.1	-2.5	1.5	1.8
Qualifications: nursing, teaching	3.1	4.8	6.3	-2.5	2.1	2.0
Osteoarthritis (self-reported)	3.1	4.0	5.1	-1.3	2.2	2.3
Worry (Nagel 2018)	3.0	6.4	10.7	-2.2	3.3	1.9
Relative age voice broke	3.0	4.5	10.6	3.2	-0.6	-1.6
Leg fat percentage (right)	3.0	10.7	17.1	4.1	-2.8	-2.7
Ever smoked	3.0	5.3	8.6	1.6	-2.2	-2.9
Leg fat percentage (left)	3.0	10.8	16.6	4.1	-2.9	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	6.7	-2.6	1.6	0.9
Hearing difficulty/problems: Yes	2.8	4.3	6.6	2.6	-1.4	-2.1
Medication: Ramipril	2.7	3.5	6.6	2.6	-1.9	-0.7
Illnesses of siblings: Diabetes	2.7	3.4	5.1	-0.3	-2.2	-2.3
Weight	2.6	12.7	22.1	4.7	-3.4	-2.1
Father’s age at death	2.5	3.4	4.5	-2.1	2.1	1.1
Number of full brothers	2.5	3.2	5.9	2.4	-1.7	-0.7
Age at first live birth	2.5	4.4	7.6	-1.2	2.8	2.0
Whole body fat mass	2.5	10.6	18.2	4.3	-3.0	-2.1
Medication for cholesterol	2.5	3.8	6.1	-2.1	2.5	1.0
Arm fat mass (left)	2.5	10.4	18.1	4.2	-3.1	-2.0
Medication: Simvastatin	2.4	3.5	4.4	2.1	-1.8	-1.7
Vitamin and mineral supplements	2.3	3.1	5.7	-0.5	2.4	1.8
Qualifications: CSEs or equivalent	2.3	3.1	4.2	1.4	-1.8	-2.1
Waist circumference	2.3	8.6	17.7	4.2	-2.3	-1.7
Arm fat mass (right)	2.3	9.6	16.9	4.1	-2.9	-1.9
Body fat percentage	2.3	9.1	16.4	4.0	-2.6	-2.0
Arm predicted mass (right)	2.3	11.9	19.5	4.4	-3.4	-2.2
Medication: Blood pressure	2.3	4.4	6.2	2.5	-2.4	-1.2
Alzheimer’s Disease (including proxy)	2.2	3.2	6.0	-1.3	1.4	2.4
Primary Biliary Cirrhosis	2.2	3.2	6.7	2.6	-1.4	-0.8
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	4.9	1.4	-2.2	-1.9
Neuroticism (Nagel 2018)	2.1	5.0	8.8	-1.9	3.0	1.7
Prostate Cancer	2.1	3.0	5.3	-2.3	1.1	1.6
Trunk fat mass	2.1	9.1	16.8	4.1	-2.7	-1.8
Arm fat-free mass (right)	2.1	10.5	18.1	4.3	-3.0	-2.1
Illnesses of father: Heart disease	2.1	2.8	6.9	-2.6	1.0	0.8
Arm fat percentage (left)	2.1	8.3	15.0	3.9	-2.5	-1.9
Arm predicted mass (left)	2.1	10.7	17.5	4.2	-3.2	-2.1
Alzheimer’s Disease (in mother)	2.0	2.3	3.5	-1.1	1.9	1.5
Ever used hormone-replacement therapy (HRT)	2.0	2.5	6.1	-0.2	1.2	2.5
Pain experienced in last month	2.0	3.3	5.1	-1.3	2.3	1.8
Trunk fat percentage	1.9	7.6	14.4	3.8	-2.4	-1.6
Arm fat percentage (right)	1.9	7.5	13.8	3.7	-2.4	-1.8
Knee pain experienced in last month	1.9	2.9	4.3	1.4	-2.1	-1.5
Arm fat-free mass (left)	1.9	9.6	16.7	4.1	-3.0	-1.8
Leg predicted mass (left)	1.8	9.5	15.0	3.9	-3.1	-2.0
Impedance of arm (right)	1.8	8.5	10.4	-2.8	3.2	2.8
Hearing aid user	1.8	2.0	3.3	1.5	-1.8	-0.6
High cholesterol (Self-reported)	1.8	3.2	6.2	0.9	-2.5	-1.6
BMI	1.7	9.8	13.5	3.7	-3.2	-2.4
Leg fat-free mass (left)	1.7	9.2	14.7	3.8	-3.1	-1.9
Stomach or abdominal pain in last month	1.7	2.1	2.1	-1.5	1.4	1.4
Forced vital capacity (FVC)	1.7	6.4	10.3	-2.2	2.0	3.2
Financial difficulties in last 2 years	1.7	2.2	3.7	1.4	-1.9	-1.1
Myopia	1.7	2.5	3.1	1.8	-1.4	-1.5
Breast Cancer	1.6	3.9	6.5	2.5	-2.2	-0.6
Ulcerative Colitis	1.6	2.3	6.7	-2.6	-0.5	-0.3
Waist Hip Ratio (WHR)	1.6	7.3	8.6	-2.7	2.9	2.5
Average weekly champagne plus white wine intake	1.6	2.2	3.2	1.8	-0.0	-1.8
Wears glasses or contact lenses	1.6	1.8	3.2	0.6	-1.4	-1.8
Basal metabolic rate	1.6	9.1	15.8	4.0	-3.0	-1.6
Pack years of smoking	1.6	2.3	4.6	2.2	-1.1	-1.0
Mean Putamen Volume	1.5	1.7	3.6	1.9	-0.6	-1.1
Fasting Glucose	1.5	1.7	2.6	1.1	-1.2	-1.6
Lung FVC	1.5	7.5	11.4	-3.4	1.8	2.8
Multivitamins +/- minerals	1.5	1.9	3.2	0.4	-1.5	-1.8
Nervous feelings	1.5	2.7	4.7	-1.6	2.2	0.9
Leg predicted mass (right)	1.5	8.0	12.0	3.5	-3.0	-1.7
Blood Red Count	1.4	13.1	21.5	-4.6	1.8	3.8
Cardiovascular Disease	1.4	4.7	6.3	2.2	-2.5	-1.7
Serious illness, injury or assault to yourself	1.4	1.6	2.3	-0.7	1.5	1.5
Had menopause	1.4	1.8	4.5	2.1	-0.3	-0.9
Mouth/teeth dental problems	1.4	2.2	4.0	-0.6	2.0	1.5
Length of working week for main job	1.4	1.6	3.4	0.9	-1.8	-0.7
Birth weight	1.4	3.0	5.1	1.4	-1.4	-2.3
Number of children fathered	1.4	1.5	3.2	1.8	-0.8	-0.9
Medication: Seretide 50 evohaler	1.4	1.6	4.2	-2.1	0.7	-0.1
Leg fat-free mass (right)	1.4	7.7	11.8	3.4	-3.0	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	2.7	-1.3	1.6	1.0
Supplements: Calcium	1.4	1.6	2.6	-0.4	-1.6	-1.4
Neuroticism (2016)	1.3	1.8	2.9	-1.4	1.7	0.8
Triglycerides	1.3	2.1	2.4	1.4	-1.3	-1.6
Number of treatments/medications taken	1.3	2.3	3.5	1.6	-1.9	-0.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.7	-1.6	1.3	-0.2
Hand grip strength (right)	1.3	3.5	6.1	1.0	-2.5	-1.8
Neuroticism score	1.3	2.7	5.7	-0.9	2.4	1.2
Impedance of arm (left)	1.3	6.2	7.6	-2.3	2.8	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.4	1.5	-1.3	-0.6
Whole body fat-free mass	1.3	7.3	13.0	3.6	-2.6	-1.4
Whole body water mass	1.3	7.4	13.2	3.6	-2.6	-1.4
Ever taken oral contraceptive pill	1.3	1.4	2.1	0.7	-1.5	-1.3
Impedance of whole body	1.3	6.4	7.8	-2.6	2.8	2.2
Hand grip strength (left)	1.2	3.0	4.6	1.4	-2.1	-1.6
Sensitivity / hurt feelings	1.2	2.1	4.6	-1.0	2.2	0.8
Relative age of first facial hair	1.2	2.4	4.9	2.2	-1.1	-1.1
Pack years adult smoking proportion	1.2	1.8	3.7	1.9	-1.0	-0.8
Illnesses of mother	1.2	1.4	3.2	-1.8	0.7	-0.8
Forced vital capacity (FVC), Best measure	1.2	4.4	6.8	-1.8	1.8	2.6
Wheeze or whistling in the chest in last year	1.2	2.1	4.3	0.4	-1.3	-2.1
Basal cell carcinoma (self-reported)	1.2	1.4	2.8	0.7	-1.0	-1.7
Body Mass Index (BMI) (2010)	1.1	1.5	3.4	1.9	-0.7	-0.7
Hypothyroidism (self reported)	1.1	2.5	6.3	-1.0	0.5	2.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.5	-1.6	1.2	0.2
Hair/balding pattern: Pattern 3	1.1	1.7	2.6	1.4	-1.6	-0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	5.4	-1.8	1.7	2.3
Happiness	1.1	1.3	1.9	-1.4	1.2	0.8
Medication: Allopurinol	1.1	1.5	2.0	-1.4	1.4	0.8
Had major operations	1.1	1.3	2.0	0.7	1.4	1.2
Heart disease (siblings)	1.1	1.3	2.2	1.5	-1.1	-0.8
Rheumatoid Arthritis	1.0	1.4	1.9	-1.4	0.7	1.3
Respiratory disease	1.0	2.2	6.4	-2.5	0.3	-0.4
Medication: Co-codamol	1.0	1.1	2.1	0.4	1.5	1.0
Maternal smoking around birth	1.0	1.5	3.1	0.7	-0.9	-1.8
Taking other prescription medications	1.0	1.5	4.1	0.5	-2.0	-0.4
Qualifications: None of the above	1.0	2.1	2.7	1.6	-1.5	-1.2
Shortness of breath walking on level ground	1.0	1.1	1.8	1.3	0.2	-1.3
Medication: Omeprazole	1.0	1.2	1.9	-0.6	1.4	1.1
Risk taking	1.0	1.5	3.0	0.4	-1.7	-1.2
Diastolic blood pressure, automated reading	1.0	3.2	8.4	2.9	-0.9	-0.6
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.4	-2.5	0.8	0.9
Bipolar Disorder (2018)	0.9	1.5	2.1	1.1	-1.0	-1.4
Ulcerative Colitis (UC)	0.9	1.6	4.0	-2.0	-0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.7	1.3	-0.8	-0.9
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	1.4	-0.2	1.0
Impedance of leg (right)	0.9	4.4	7.4	-1.9	2.7	1.5
Impedance of leg (left)	0.9	4.6	6.4	-2.1	2.5	1.8
Allergy	0.9	2.0	5.1	0.8	0.5	2.2
Trunk fat-free mass	0.9	5.3	10.8	3.3	-2.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	4.0	-1.4	1.6	2.0
Pulse wave Arterial Stiffness index	0.9	1.0	1.5	0.7	1.1	1.2
Trunk predicted mass	0.9	5.4	10.8	3.3	-2.1	-0.9
Tense / ‘highly strung’	0.9	1.4	2.2	-1.5	1.3	0.7
Hair/balding pattern: Pattern 4	0.9	2.1	5.0	-2.2	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.7	-0.9	1.3	1.0
Chest pain or discomfort	0.9	1.3	1.7	1.3	-1.2	-0.8
Back pain experienced in last month	0.9	1.3	2.0	0.7	-1.1	-1.4
Medication: Gliclazide	0.9	1.0	1.8	-1.4	-0.9	-0.5
Schizophrenia (2018)	0.8	1.7	2.2	-1.5	1.4	0.9
Coronary Artery Disease (CAD)	0.8	1.0	1.5	-1.1	-0.5	-1.2
HDL Cholesterol	0.8	1.4	4.0	-2.0	0.1	-0.2
Diabetes (mother)	0.8	1.0	2.0	1.4	-0.8	0.7
Average weekly fortified wine intake	0.8	0.9	1.5	0.7	-0.8	-1.2
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	1.0	0.0	-1.3
Pulse wave peak to peak time	0.8	1.0	1.4	-0.5	-1.1	-1.2
Medication: Ibuprofen	0.8	0.9	1.8	1.3	-0.6	-0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	0.6	0.5	1.5
Medication: Atorvastatin	0.8	1.1	2.3	1.5	0.2	0.9
Irritability	0.8	1.3	2.1	-1.4	1.3	0.5
Ever depressed for a whole week	0.8	1.0	2.4	-0.7	1.6	-0.2
Major Depression (MDD)	0.7	0.9	2.1	-0.7	-0.1	-1.4
Crohns Disease (2012)	0.7	1.2	3.3	-1.8	0.5	-0.1
Neuroticism	0.7	1.6	3.4	-0.8	1.8	0.8
Average weekly spirits intake	0.7	0.9	1.9	0.5	-0.8	-1.4
Diabetes (self-reported)	0.7	1.1	1.4	-1.0	-1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.3	-1.5	-0.3	-0.7
Fluid intelligence score	0.7	1.5	3.3	1.1	-0.1	-1.8
Asthma	0.7	1.3	2.6	-1.0	-0.5	-1.6
Breastfed as a baby	0.7	0.8	2.0	1.4	-0.1	-0.7
Loud music exposure frequency	0.7	0.8	1.0	0.9	-1.0	-0.8
Worry too long after embarrassment	0.7	1.2	2.1	-1.1	1.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	0.5	1.4	0.5
Neck or shoulder pain in last month	0.7	1.0	2.4	0.6	-1.5	-0.6
Alcohol intake frequency.	0.7	1.7	2.6	1.6	-1.6	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.4	-0.0	-1.2	-1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	-1.3	0.6	0.6
Ovarian Cancer	0.6	0.8	2.0	-1.4	0.3	0.4
LDL Cholesterol	0.6	0.9	2.3	-0.4	0.6	1.5
Blood White Count	0.6	4.7	12.1	-1.0	-1.0	-3.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-0.4	-0.0	1.5
Medication: Metformin	0.6	0.8	1.4	0.0	-1.0	-1.2
High blood pressure	0.6	1.6	3.8	1.9	-0.6	-0.8
Had other major operations	0.6	0.7	1.1	1.0	-0.9	-0.3
Qualifications: College or University degree	0.6	2.0	3.6	-1.9	1.4	0.7
Leg pain on walking	0.6	0.7	1.0	-1.0	1.0	0.4
Miserableness	0.6	1.0	1.5	1.2	-0.7	-1.0
Illnesses of father: High blood pressure	0.6	0.7	1.5	0.7	0.3	-1.2
Commuting to job workplace: Cycle	0.6	0.7	1.0	-0.8	1.0	-0.6
Irritable Bowel Disease (IBD)	0.5	1.2	3.2	-1.8	-0.1	-0.7
Blood Platelet Count	0.5	5.5	8.4	2.9	-0.8	-2.8
Townsend deprivation index at recruitment	0.5	0.6	1.4	0.6	-0.5	-1.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	-1.4	0.7	-0.8
High blood pressure (mother)	0.5	0.7	1.6	-0.3	1.3	0.5
Pulse rate	0.5	0.8	1.4	0.7	1.2	0.7
Depression (self-reported)	0.5	0.6	1.6	-0.5	-1.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.1	-0.9	1.0	0.6
Glaucoma (self-reported)	0.5	0.6	1.1	-1.0	-0.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.4	-0.4	-0.6	1.5
Medication: Amlodipine	0.5	0.8	1.4	-1.2	-0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.1	-1.0	-0.8
Mean time to correctly identify matches	0.5	0.9	2.0	-1.4	-0.6	0.6
Pulse rate, automated reading	0.5	1.7	2.6	1.5	-0.4	-1.6
Age at last live birth	0.5	0.7	2.1	0.2	1.5	0.1
Medication: Aspirin	0.5	0.6	1.6	1.3	-0.3	-0.4
Hypertension (Self-reported)	0.5	1.5	3.3	1.8	-0.6	-0.8
Friendships satisfaction	0.5	0.6	1.1	-1.1	-0.6	-0.7
Commuting to job workplace: Walk	0.5	0.6	1.1	0.7	0.4	-1.0
Asthma (self-reported)	0.5	1.1	2.3	-1.5	0.0	-1.0
Medication: Aspirin	0.5	0.7	1.9	1.4	-0.1	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.5	0.4	1.2
Medication: Bendroflumethiazide	0.5	0.7	1.7	1.3	-0.5	0.4
Alcohol drinker status: Previous	0.5	0.5	0.9	0.4	-0.7	-0.9
Reaction Time	0.4	0.8	2.3	-1.5	-0.3	0.2
Allergy or Eczema	0.4	0.9	1.7	-1.3	0.5	-0.9
Current tobacco smoking	0.4	0.6	1.0	0.0	-0.9	-1.0
Medication: Levothyroxine sodium	0.4	0.7	1.5	-0.3	-0.7	1.2
Medication: Lansoprazole	0.4	0.5	0.7	-0.5	0.8	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-1.2	0.2	0.2
Blood clot in the leg (DVT)	0.4	0.5	1.1	1.1	0.3	-0.4
Gout (self-reported)	0.4	0.5	0.8	-0.4	0.8	0.9
Health satisfaction	0.4	0.5	1.0	1.0	0.4	0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	-0.4	-1.2	-0.5
Number of full sisters	0.4	0.4	1.0	-0.1	-0.5	-1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.1	-0.6	-1.1
Diabetes diagnosed by doctor	0.4	0.7	0.8	-0.7	-0.8	-0.9
Mother’s age at death	0.4	0.5	1.3	-0.0	0.4	1.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.4	0.6	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	1.1	0.3	-0.5
Alzheimer’s Disease (in father)	0.3	0.4	0.5	-0.3	-0.7	0.7
HbA1C	0.3	0.3	0.9	-0.2	-1.0	-0.3
Blood Eosinophil Count	0.3	2.2	3.6	-1.7	0.4	-1.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	1.0	-0.5	-0.2
Supplements: Zinc	0.3	0.3	0.5	-0.7	-0.5	-0.5
Fed-up feelings	0.3	0.6	0.7	0.8	-0.7	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	0.7	-0.2	0.8	0.8
Supplements: Glucosamine	0.3	0.4	1.1	-1.1	-0.1	0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	0.7	-0.6	-0.6
Alcohol intake versus 10 years previously	0.3	0.4	0.9	0.6	0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	0.6	-0.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	-1.4	0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.5	0.1	0.8
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	0.0	1.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	1.0	-0.4	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.4	-0.5	0.7
Overall health rating	0.3	0.6	1.7	1.3	-0.0	-0.3
Loneliness, isolation	0.3	0.4	0.8	0.2	0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.2	-0.4	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.4	0.7	0.5	-0.5
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	0.8	-0.6	0.6
Commuting to job workplace: Public transport	0.3	0.4	1.1	1.0	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.5	0.4	0.9
Medication: Paracetamol	0.3	0.5	1.5	1.2	0.3	-0.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	0.0	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	0.2	-0.1	-1.2
Heel T-Score	0.2	1.9	5.0	-2.2	-0.0	-0.9
Height	0.2	3.5	6.0	2.1	-2.4	-0.2
Chronotype (morning person)	0.2	0.5	1.1	-0.6	-0.1	1.1
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.0	-0.5	0.6
Diabetes (father)	0.2	0.2	0.5	0.1	-0.3	-0.7
Sitting height	0.2	1.4	2.4	0.4	1.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.9	0.1	0.2
Hearing difficulty/problems with background noise	0.2	0.2	0.5	0.7	-0.4	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	0.5	0.7	0.2
Noisy workplace	0.2	0.3	0.4	-0.5	0.6	0.4
Lung cancer (father)	0.2	0.2	0.3	-0.4	-0.3	0.5
Medication: Paracetamol	0.2	0.4	0.7	0.5	0.9	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.3	-0.2	-0.7
Medication: Blood pressure	0.2	0.3	0.6	-0.2	0.8	0.5
Migraine (self-reported)	0.2	0.3	0.8	-0.9	-0.0	-0.0
Heart disease (mother)	0.2	0.3	0.4	0.3	-0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.3	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.7	-0.5	0.9	0.7
Smoking status: Current	0.2	0.4	0.9	-0.1	-0.5	-1.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.7	0.5	-0.1
Medication: Lisinopril	0.2	0.2	0.5	0.7	-0.3	-0.3
Alcohol drinker status: Never	0.2	0.3	0.8	0.9	0.2	0.1
Age started oral contraceptive pill	0.2	0.3	0.8	0.1	0.9	0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	-0.5	0.5	-0.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.1	0.5	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	0.3	-0.0	-1.0
Crohns Disease (2017)	0.1	0.3	0.4	-0.7	0.5	-0.3
Age at First Birth	0.1	0.2	0.3	0.6	0.5	0.3
Schizophrenia (2014)	0.1	0.2	0.3	-0.5	0.5	0.3
Lung FEV1/FVC ratio	0.1	0.6	1.2	0.5	-0.6	-1.1
Tanning	0.1	1.3	2.0	0.4	1.4	1.3
Systolic blood pressure, automated reading	0.1	0.4	1.2	1.1	0.1	0.3
Angina	0.1	0.1	0.1	0.4	-0.2	0.3
Age when periods started (menarche)	0.1	0.3	0.6	0.6	-0.8	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.3	-0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.9	0.3	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.1	-0.3	-0.2
Medication: Atenolol	0.1	0.1	0.2	0.4	-0.1	0.4
Alcohol usually taken with meals	0.1	0.2	0.3	0.5	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.2	-0.2	-0.5
Heart attack	0.1	0.1	0.2	0.3	0.4	0.0
Falls in the last year	0.1	0.2	0.3	-0.5	-0.0	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	-0.2	-0.3
Standing height	0.1	0.9	2.0	0.9	0.0	1.4
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.8	-0.5	-0.1
Pulse wave reflection index	0.1	0.1	0.2	0.4	-0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.2	-0.4	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.6	-0.3	0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	0.2	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.1	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.5	0.1	0.1
Angina (self-reported)	0.1	0.2	0.4	0.7	-0.3	0.1
Comparative height size at age 10	0.1	0.6	0.7	-0.6	0.8	0.8
Suffer from ‘nerves’	0.1	0.2	0.6	-0.0	0.7	0.1
Family relationship satisfaction	0.1	0.1	0.2	0.5	-0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	-0.2	0.0
Supplements: Vitamin C	0.1	0.1	0.1	-0.2	-0.1	-0.4
Average weekly red wine intake	0.1	0.1	0.3	0.1	-0.1	0.5
Ever had bowel cancer screening	0.1	0.2	0.3	0.3	-0.3	-0.5
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	-0.3	0.4
Guilty feelings	0.1	0.1	0.2	-0.3	0.1	0.5
Number of operations (self-reported)	0.1	0.1	0.3	0.1	0.2	0.5
Unable to work because of sickness or disability	0.1	0.2	0.3	0.1	-0.6	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.4	0.4	0.1
Depression (Nagel 2018)	0.0	0.0	0.1	-0.1	-0.2	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.2	-0.1
Systolic Blood Pressure	0.0	0.2	0.2	-0.4	-0.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.1	0.0
Hair Pigment	0.0	0.7	1.7	-1.3	-0.3	-0.6
Time employed in main current job	0.0	0.0	0.1	0.2	-0.1	0.2
Birth weight of first child	0.0	0.1	0.2	-0.2	-0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	-0.2	0.1	-0.4
Headache pain in last month	0.0	0.1	0.1	0.3	0.1	-0.3
Mood swings	0.0	0.1	0.2	0.1	0.1	-0.5
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.2	-0.0	0.3
Mineral and other dietary supplements	0.0	0.0	0.1	0.1	0.2	0.3
Financial situation satisfaction	0.0	0.1	0.1	0.3	-0.3	-0.2

Hub : Genes

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Trait associations