TWAS hub - ITGAD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1034	0.0334	4.4e-09	0.037	0.054	0.065	0.059	0.052	2.5e-06	1.4e-08	5.0e-10	2.9e-09	2.9e-08
2	TCGA	Bladder Urothelial Carcinoma	0.2100	0.0820	3.7e-07	0.114	0.114	0.094	NA	0.111	7.0e-10	7.1e-10	2.5e-08	NA	1.3e-09
3	TCGA	Breast Invasive Carcinoma	0.0694	0.0246	8.4e-10	0.039	0.055	0.056	NA	0.043	1.8e-08	2.0e-11	1.2e-11	NA	2.8e-09
4	TCGA	Cervical Squamous Cell Carcinoma	0.1880	0.0700	5.9e-06	0.177	0.146	0.160	NA	0.154	4.6e-09	1.2e-07	2.8e-08	NA	5.0e-08
5	TCGA	Colon Adenocarcinoma	0.1080	0.0520	1.0e-04	0.096	0.064	0.067	NA	0.083	3.4e-06	1.4e-04	9.8e-05	NA	1.6e-05
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.1222	0.0475	1.2e-07	0.083	0.060	0.053	NA	0.072	1.4e-09	2.5e-07	1.3e-06	NA	1.9e-08
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1330	0.0540	4.4e-05	0.082	0.089	0.081	NA	0.067	1.9e-05	8.5e-06	2.1e-05	NA	1.0e-04
8	TCGA	Lung Adenocarcinoma	0.1182	0.0471	2.7e-06	0.035	0.034	0.044	NA	0.050	4.9e-05	7.2e-05	6.8e-06	NA	1.4e-06
9	TCGA	Lung Squamous Cell Carcinoma	0.1228	0.0484	3.8e-06	0.060	0.048	0.051	NA	0.045	2.2e-07	3.3e-06	1.8e-06	NA	7.4e-06
10	TCGA	Prostate Adenocarcinoma	0.0559	0.0216	7.8e-07	0.069	0.059	0.056	NA	0.063	9.8e-08	8.2e-07	1.5e-06	NA	3.7e-07
11	TCGA	Stomach Adenocarcinoma	0.0900	0.0520	3.6e-03	0.067	0.028	0.041	NA	0.048	1.4e-05	3.9e-03	5.5e-04	NA	2.2e-04
12	TCGA	Testicular Germ Cell Tumors	0.1630	0.0870	7.2e-03	0.010	0.026	0.040	NA	0.034	1.4e-01	4.0e-02	1.5e-02	NA	2.3e-02
13	TCGA	Thyroid Carcinoma	0.0740	0.0350	2.8e-04	0.055	0.049	0.053	NA	0.053	4.8e-06	1.6e-05	7.2e-06	NA	6.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Reason for reducing amount of alcohol drunk: Health precaution	5.3	6.2	9.8	-2.2	-2.6	-1.6	-2.8	-2.9	-2.9	-1.5	-3.1	-2.6	-0.3	-2.9	-2.5	-2.9
Wheeze or whistling in the chest in last year	4.9	8.7	18.7	-4.3	-3.5	-0.7	-3.4	-3.3	-3.5	-0.6	-2.9	-3.0	1.1	-3.5	-1.9	-3.3
Lupus	4.5	6.8	30.1	-0.2	5.5	1.9	1.3	1.3	0.8	-1.3	1.1	5.5	-1.1	0.9	3.8	1.2
Shortness of breath walking on level ground	4.5	5.3	9.0	-3.0	-2.5	-0.7	-2.9	-2.8	-2.7	-1.2	-2.9	-1.6	0.3	-2.6	-1.9	-2.7
Number of full sisters	4.2	5.2	9.1	-2.7	-2.2	1.4	-2.7	-2.6	-3.0	1.5	-1.9	-1.4	2.5	-2.9	-0.7	-2.6
Time employed in main current job	3.5	4.1	7.3	-1.7	-1.9	-1.7	-2.0	-2.2	-2.1	-1.7	-2.5	-2.0	-1.1	-2.0	-2.7	-2.2
Diverticular disease/diverticulitis (self-reported)	3.4	4.0	6.7	-1.6	-2.4	-1.1	-2.2	-2.4	-2.1	-0.9	-2.6	-2.4	0.4	-2.1	-2.0	-2.4
Illnesses of siblings	3.2	4.5	14.1	3.8	1.9	-1.8	2.5	2.2	2.4	-0.5	1.6	0.7	-2.5	2.3	-0.6	2.1
Townsend deprivation index at recruitment	3.1	4.4	8.7	-2.8	-2.2	1.2	-2.3	-2.3	-2.2	1.6	-1.8	-1.0	3.0	-2.2	-1.1	-2.3
Type 2 Diabetes (T2D) (2012)	3.0	3.4	6.9	-1.9	-1.7	-1.9	-1.8	-2.0	0.0	-2.6	-2.4	-1.9	-1.1	-1.5	-1.9	-1.9
Angina	2.9	3.9	7.0	-2.3	-2.0	-0.5	-2.0	-2.5	-2.6	-0.2	-2.3	-1.7	0.6	-2.5	-1.4	-2.7
Birth weight	2.8	6.1	11.6	-2.8	-3.4	1.5	-2.9	-2.8	-2.9	0.8	-2.3	-1.6	2.7	-2.8	-1.3	-2.9
Qualifications: CSEs or equivalent	2.7	3.6	5.4	-2.0	-2.1	0.3	-2.3	-2.3	-2.1	-0.2	-2.1	-1.9	1.5	-2.0	-2.0	-2.2
Medication: Simvastatin	2.7	4.0	14.7	-3.8	-1.8	-0.6	-2.0	-2.2	-2.2	-0.8	-2.0	-1.7	0.9	-2.1	-1.3	-2.3
Mouth/teeth dental problems: Dentures	2.6	4.3	7.1	-1.8	-2.2	-1.3	-2.3	-2.5	-2.7	-0.9	-2.3	-2.2	-0.1	-2.6	-1.9	-2.5
Angina (self-reported)	2.6	3.4	6.2	-2.3	-1.8	-0.6	-1.9	-2.3	-2.4	-0.4	-2.2	-1.6	0.5	-2.3	-1.3	-2.5
Average weekly champagne plus white wine intake	2.6	3.6	13.8	-0.8	-1.8	2.6	-1.8	-1.8	-1.6	2.7	-0.7	0.0	3.7	-1.6	0.0	-1.6
Medication: Ramipril	2.5	3.2	10.6	-3.3	-1.6	-1.7	-1.4	-1.2	-1.5	-2.5	-1.5	-2.2	-1.1	-1.6	-1.0	-1.6
Illnesses of siblings: Diabetes	2.5	3.1	5.4	-2.3	-2.2	0.3	-2.2	-1.9	-2.0	-0.4	-1.7	-2.0	0.7	-2.0	-1.2	-1.9
Alzheimer’s Disease (in father)	2.4	2.6	4.7	1.6	1.7	-0.8	2.2	2.1	2.0	-0.8	1.5	0.9	-1.6	1.9	1.1	1.9
Vitamin and mineral supplements	2.3	3.2	5.1	1.5	2.0	-0.4	2.3	2.1	2.0	0.2	2.0	1.8	-1.1	1.9	2.2	2.1
Cholesterol lowering medication	2.3	3.5	22.4	-4.7	-0.6	0.2	-1.7	-1.9	-1.9	-0.8	-1.8	-0.6	0.8	-1.8	-0.3	-2.0
Hearing difficulty/problems: Yes	2.2	3.4	6.2	-2.4	-1.7	0.5	-2.4	-2.1	-2.5	0.3	-1.6	-1.2	1.4	-2.5	-1.1	-2.3
Worry (Nagel 2018)	2.1	4.5	19.0	4.4	1.9	1.0	2.2	2.1	1.9	2.1	1.9	1.6	0.8	2.0	1.4	2.1
Multivitamins +/- minerals	2.1	2.7	4.4	-1.1	-1.8	1.2	-2.1	-1.9	-2.0	0.3	-1.6	-1.4	1.4	-1.9	-1.6	-1.9
Falls in the last year	2.1	2.9	6.7	-2.6	-2.5	-0.5	-1.6	-1.8	-2.1	0.6	-1.7	-1.4	1.1	-1.9	-1.0	-2.0
Chest pain or discomfort	2.1	3.1	8.6	-2.9	-1.4	0.7	-2.0	-2.1	-2.2	0.3	-1.8	-0.8	1.2	-2.2	-0.9	-2.2
Illnesses of father: High blood pressure	2.1	2.6	5.1	-2.2	-1.8	1.1	-2.0	-1.9	-1.8	0.8	-1.5	-0.9	1.7	-1.8	-1.1	-1.7
Number of incorrect matches in round	2.0	3.3	14.8	3.9	1.4	-2.1	2.0	1.6	1.6	-0.4	1.1	0.9	-2.1	1.6	0.6	1.6
Medication: Aspirin	1.9	2.5	8.0	-2.8	-1.7	-1.3	-1.3	-1.7	-1.7	-0.9	-1.7	-1.2	0.3	-1.7	-0.4	-2.1
Medication: Gliclazide	1.9	2.2	6.5	-1.0	-1.4	-2.4	-0.3	-0.1	-0.1	-2.5	-0.5	-2.0	-2.5	-0.3	-1.6	-0.2
Body Mass Index (BMI) (2010)	1.8	2.4	7.0	-2.7	-1.1	0.6	-2.0	-2.2	0.0	-0.4	-2.0	-0.5	1.1	-1.8	-0.9	-2.0
Lung FEV1/FVC ratio	1.8	9.2	19.5	4.4	2.8	4.1	1.9	2.2	2.0	3.9	3.2	3.7	2.4	2.1	2.7	2.4
Fluid intelligence score	1.8	3.8	16.2	-0.4	-0.4	4.0	-0.3	-0.1	-0.0	3.7	0.9	1.0	4.0	0.0	0.8	0.0
Happiness	1.8	2.2	4.4	2.0	0.4	-0.3	2.1	1.9	1.9	0.6	1.8	0.6	-0.7	1.8	1.3	1.7
Basal cell carcinoma (self-reported)	1.8	2.1	8.0	1.6	-0.5	2.7	-0.2	-0.1	-0.1	2.8	0.8	1.0	2.7	-0.0	0.7	0.1
LDL Cholesterol	1.7	2.7	5.8	0.7	1.8	0.6	2.0	2.2	0.0	1.3	2.4	1.7	0.3	1.8	2.1	2.1
Average weekly fortified wine intake	1.7	2.0	3.4	-0.8	-1.7	0.2	-1.7	-1.8	-1.5	0.2	-1.8	-1.0	1.3	-1.5	-1.3	-1.7
Had menopause	1.7	2.2	5.0	-2.2	-1.4	-1.6	-1.5	-1.6	-1.7	-1.2	-1.5	-1.1	0.0	-1.7	-0.2	-1.8
High blood pressure (siblings)	1.7	2.5	9.7	-3.1	-0.8	1.8	-1.6	-1.3	-1.4	1.1	-0.6	0.2	2.7	-1.2	0.9	-1.1
Knee pain experienced in last month	1.7	2.7	9.9	-3.1	-2.1	1.4	-1.5	-1.4	-1.6	0.7	-0.9	-0.9	2.3	-1.4	0.2	-1.5
Friendships satisfaction	1.7	2.1	3.7	1.8	0.9	0.8	1.9	1.9	1.9	0.9	1.7	0.8	-0.2	1.9	0.9	1.9
Medication for cholesterol	1.7	2.6	14.0	3.7	0.7	-0.5	1.7	1.8	1.7	0.6	1.5	0.6	-0.8	1.6	0.6	1.8
Blood Platelet Count	1.6	18.0	77.6	0.0	-2.1	7.3	-3.2	-3.0	-3.1	7.0	-0.7	1.6	8.8	-2.8	1.3	-2.6
Mood swings	1.6	2.9	5.5	-0.2	-1.9	-1.0	-2.0	-1.9	-2.2	-0.8	-1.9	-2.4	0.4	-2.1	-1.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	22.6	4.8	1.7	-0.4	2.0	1.3	1.8	1.2	1.0	1.0	-0.7	1.7	-0.3	1.5
Medication: Blood pressure	1.6	3.0	15.8	-4.0	-1.3	-0.5	-1.7	-1.9	-1.6	-1.5	-1.9	-0.9	0.4	-1.6	-0.2	-1.8
Fractured/broken bones in last 5 years	1.6	2.0	7.5	-2.7	0.5	1.7	-1.4	-1.4	-1.4	0.6	-0.9	0.9	2.0	-1.2	0.7	-1.3
Heart attack/myocardial infarction (self-reported)	1.6	2.0	3.3	-1.8	-1.3	-0.7	-1.5	-1.5	-1.7	-0.5	-1.6	-1.6	0.1	-1.7	-1.3	-1.7
Schizophrenia vs Biploar Disorder	1.5	2.0	3.7	1.7	1.5	0.1	1.6	1.8	1.8	-0.2	1.7	0.7	-1.2	1.6	0.8	1.9
Relative age voice broke	1.5	2.2	6.0	-2.4	-1.7	-0.5	-1.6	-1.7	-1.5	-1.2	-1.6	-1.0	0.1	-1.5	-1.3	-1.8
Supplements: Glucosamine	1.5	2.0	3.8	0.1	-1.6	0.1	-1.7	-1.6	-1.9	0.2	-1.4	-1.5	0.5	-1.8	-1.9	-1.6
Heart attack	1.5	2.0	3.2	-1.8	-1.2	-0.6	-1.5	-1.6	-1.6	-0.4	-1.6	-1.6	0.1	-1.7	-1.4	-1.7
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	23.5	4.8	2.2	0.9	2.3	2.1	2.5	1.3	1.9	1.8	-0.6	2.4	0.2	2.3
Neck or shoulder pain in last month	1.5	2.1	5.5	-2.3	-1.9	0.4	-1.4	-1.7	-1.6	0.5	-1.3	-0.9	1.5	-1.5	-0.2	-1.8
Mean time to correctly identify matches	1.5	2.9	13.0	-0.7	0.7	-3.6	1.0	1.0	1.0	-3.0	-0.0	-0.6	-3.1	0.9	0.2	0.9
Forced vital capacity (FVC)	1.4	5.3	21.3	4.6	2.4	-0.1	2.7	2.3	2.8	0.6	1.8	1.8	-1.3	2.6	0.3	2.4
Glaucoma (self-reported)	1.4	1.6	7.4	1.1	0.0	-2.1	1.0	1.1	0.9	-1.7	0.4	-0.5	-2.7	0.9	-0.7	0.9
Had major operations	1.4	1.6	3.1	-1.6	-1.6	-1.8	-0.8	-1.0	-0.9	-1.2	-1.3	-1.3	-0.8	-1.0	-1.6	-1.3
Medication: Aspirin	1.4	1.9	7.7	-2.8	-1.4	-1.0	-1.0	-1.5	-1.4	-0.6	-1.5	-0.9	0.4	-1.4	-0.1	-1.7
Verbal and Numeric Reasoning (VNR)	1.3	3.1	7.4	0.7	0.9	2.5	1.3	1.5	1.2	2.7	2.2	1.3	2.3	1.3	2.1	1.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.5	-1.6	-1.4	-1.5	-1.0	-1.0	-1.2	-1.2	-1.2	-1.5	-1.1	-1.2	-1.5	-1.2
Medication: Metformin	1.3	1.9	5.2	-1.3	0.1	-2.3	1.2	1.3	1.3	-2.0	0.6	-0.3	-2.3	1.2	0.7	1.1
Alcohol intake versus 10 years previously	1.3	1.9	5.1	0.5	2.1	0.4	1.3	1.6	1.4	-0.1	1.3	2.2	-0.7	1.4	1.2	1.6
Leg fat percentage (right)	1.3	4.7	32.9	-5.7	-1.6	-0.5	-2.2	-1.8	-1.9	-1.7	-1.7	-0.8	0.8	-1.8	0.7	-1.7
Number of children fathered	1.3	1.4	2.2	-1.1	-1.1	1.2	-1.5	-1.2	-1.4	0.5	-0.9	-0.9	1.3	-1.5	-0.7	-1.5
Emphysema/chronic bronchitis	1.3	1.4	4.4	-2.1	-1.0	-0.7	-1.4	-1.1	-1.4	-1.1	-1.5	-0.8	-0.6	-1.4	-0.2	-1.2
Unable to work because of sickness or disability	1.3	1.7	7.1	-2.7	-1.7	-0.4	-1.2	-1.2	-1.4	-0.1	-0.8	-1.3	0.7	-1.3	0.0	-1.3
Triglycerides	1.2	1.9	14.1	-3.8	-1.4	-0.4	-1.4	-1.1	0.0	-0.6	-0.9	-1.2	0.6	-1.2	0.0	-1.1
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.8	-0.5	-1.2	1.8	-1.0	-1.0	-1.3	1.8	-0.6	-0.6	2.2	-1.3	-0.7	-1.4
Relative age of first facial hair	1.2	2.5	8.9	-3.0	-1.3	-1.3	-1.5	-1.5	-1.5	-2.0	-1.6	-1.2	-0.5	-1.5	-0.9	-1.6
Body mass index (BMI)	1.2	5.1	34.2	-5.8	-1.4	1.5	-1.9	-1.5	-1.7	0.0	-0.8	0.4	2.8	-1.5	2.6	-1.3
Medication: Cholesterol lowering	1.2	1.9	10.6	-3.2	-1.4	-1.9	-0.3	-0.8	-0.6	-1.2	-0.7	-2.0	-0.3	-0.6	-0.4	-1.0
Lung cancer (father)	1.2	1.4	3.3	0.9	1.4	-0.0	1.3	1.5	1.0	-0.1	1.3	1.0	-1.0	1.1	1.8	1.4
Illnesses of mother	1.2	1.5	4.7	0.2	-2.2	-1.4	-0.6	-0.9	-0.7	-0.8	-1.2	-2.0	-0.9	-0.8	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	21.5	4.6	2.0	0.4	1.9	1.8	2.0	1.1	1.5	1.6	-0.7	1.9	-0.2	1.9
Medication: Bendroflumethiazide	1.2	1.8	10.1	-3.2	-1.2	-1.5	-0.8	-1.2	-1.0	-1.1	-1.2	-0.9	0.4	-0.8	0.6	-1.2
Medication: Atorvastatin	1.2	1.5	2.8	-1.5	1.3	-0.7	1.5	1.2	1.4	-0.5	1.2	1.0	-0.7	1.3	1.7	1.1
Leg fat percentage (left)	1.2	4.4	32.5	-5.7	-1.6	-0.4	-2.0	-1.6	-1.8	-1.6	-1.5	-0.7	0.9	-1.6	1.1	-1.6
Prostate Cancer	1.1	1.5	2.7	1.6	0.7	-1.3	1.6	1.4	1.4	-0.2	1.3	0.5	-1.6	1.4	0.3	1.3
Cardiovascular Disease	1.1	3.7	23.4	-4.8	-1.5	1.2	-1.7	-2.0	-1.6	0.1	-1.4	-0.8	1.9	-1.5	0.2	-1.8
Lung FVC	1.1	5.5	26.5	5.2	2.2	-0.6	2.8	2.4	2.6	1.1	1.9	1.2	-1.2	2.5	0.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.8	-0.7	-1.5	-0.6	-1.6	-1.7	-1.6	-0.7	-2.0	-2.0	-0.4	-1.6	-2.4	-1.7
Hair/balding pattern: Pattern 2	1.1	1.4	3.9	1.6	1.6	1.4	0.8	1.0	0.9	1.0	1.1	2.0	0.3	0.9	0.7	1.1
Qualifications: None of the above	1.1	2.3	7.0	-2.1	-0.4	-2.2	-1.1	-1.2	-1.1	-2.6	-1.5	-1.2	-1.5	-1.1	-0.7	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	5.4	-1.3	-1.6	1.4	-1.3	-1.4	-1.3	1.5	-1.0	-0.4	2.3	-1.2	0.1	-1.4
Mouth/teeth dental problems: Loose teeth	1.1	1.2	3.3	-1.8	-0.8	-1.7	-0.9	-0.9	-0.7	-1.3	-1.2	-1.2	-0.9	-0.8	-1.0	-0.8
Leg fat mass (right)	1.1	4.4	32.3	-5.7	-1.6	0.6	-2.1	-1.6	-1.7	-0.8	-1.2	-0.1	2.0	-1.5	1.5	-1.5
Ever smoked	1.1	2.0	5.4	-2.3	-1.7	1.5	-1.4	-1.4	-1.2	0.7	-1.2	-0.7	1.7	-1.2	-0.8	-1.5
Vascular/heart problems diagnosed by doctor	1.1	3.1	21.2	4.6	1.3	0.5	1.5	1.7	1.5	0.8	1.4	0.7	-1.2	1.4	-0.8	1.6
Leg fat mass (left)	1.1	4.3	30.9	-5.6	-1.5	0.8	-1.9	-1.5	-1.6	-0.5	-1.0	0.1	2.2	-1.4	1.8	-1.3
Blood Red Count	1.0	9.9	35.8	6.0	1.4	-3.0	4.0	3.6	3.4	-0.4	2.9	-0.2	-3.5	3.2	0.4	3.0
BMI	1.0	5.7	33.8	-5.8	-1.2	2.2	-1.9	-1.6	-1.7	0.7	-0.7	0.9	3.3	-1.5	3.0	-1.3
Nervous feelings	1.0	1.9	10.9	3.3	0.9	0.7	1.3	1.1	1.1	1.7	1.1	0.7	1.0	1.2	0.5	1.2
Hip circumference	1.0	4.4	32.3	-5.7	-0.5	1.6	-1.0	-0.5	-0.8	-0.3	0.3	1.2	2.2	-0.6	3.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.8	-0.4	-0.9	1.1	-1.2	-1.3	-1.3	0.8	-1.1	-0.8	1.0	-1.3	-1.4	-1.2
Impedance of arm (left)	1.0	4.7	21.7	2.7	1.2	-3.0	1.3	1.1	1.2	-2.6	-0.0	-1.2	-4.7	0.9	-2.6	0.8
Length of working week for main job	1.0	1.2	1.9	-0.6	-1.2	-0.3	-1.4	-1.2	-1.4	-0.5	-1.1	-1.1	0.3	-1.3	-1.2	-1.3
Forced vital capacity (FVC), Best measure	1.0	3.6	16.2	4.0	1.8	-0.8	2.2	1.9	2.3	0.0	1.3	1.0	-1.7	2.0	-0.3	1.9
Body fat percentage	1.0	4.0	32.5	-5.7	-1.3	-0.4	-1.7	-1.4	-1.5	-1.9	-1.4	-0.4	0.4	-1.4	1.2	-1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	5.1	2.3	1.0	0.1	1.4	1.5	1.7	0.2	1.4	0.7	-0.7	1.6	0.4	1.6
Medication: Omeprazole	1.0	1.2	4.6	0.9	1.0	1.8	0.2	0.1	-0.2	2.1	0.6	1.3	1.7	-0.1	0.7	0.0
Arm fat percentage (left)	1.0	3.9	32.3	-5.7	-1.3	-0.3	-1.6	-1.4	-1.4	-1.7	-1.1	-0.4	0.7	-1.3	1.5	-1.3
Ever had bowel cancer screening	1.0	1.2	3.9	-0.9	-2.0	-0.9	-0.9	-0.9	-1.1	-0.6	-0.9	-1.7	-0.0	-1.0	-0.8	-1.1
Guilty feelings	1.0	1.5	2.7	1.6	0.9	1.5	1.2	1.2	1.1	1.6	1.4	1.2	0.9	1.2	0.7	1.3
Commuting to job workplace: Cycle	1.0	1.2	2.8	-0.6	-1.5	-1.4	-0.8	-1.1	-0.9	-0.7	-1.1	-1.7	-0.2	-0.8	-1.5	-1.0
Depression (Nagel 2018)	0.9	1.3	3.1	-0.6	-1.8	0.2	-1.1	-1.2	-1.3	0.7	-0.9	-1.5	0.9	-1.3	-1.1	-1.3
Alzheimer’s Disease (including proxy)	0.9	1.3	6.7	2.6	1.3	-1.1	0.9	0.6	0.5	-0.8	0.0	0.4	-1.9	0.4	-0.5	0.4
Ovarian Cancer	0.9	1.1	1.9	1.2	0.6	-0.9	1.4	1.4	1.3	-0.4	1.2	0.0	-1.4	1.2	0.5	1.3
High blood pressure	0.9	2.5	17.2	-4.1	-1.3	-0.1	-1.3	-1.6	-1.3	-0.4	-1.2	-0.6	1.4	-1.1	0.7	-1.4
Waist circumference	0.9	3.3	30.2	-5.5	-0.8	-0.1	-1.1	-0.7	-1.0	-1.2	-0.4	0.5	1.1	-0.8	2.3	-0.7
Impedance of arm (right)	0.9	4.4	18.3	3.1	1.5	-2.5	1.8	1.4	1.7	-2.0	0.4	-0.6	-4.3	1.4	-2.1	1.2
Arm fat mass (right)	0.9	3.7	28.9	-5.4	-1.1	1.0	-1.5	-1.1	-1.2	-0.5	-0.6	0.5	2.0	-1.1	2.4	-1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.7	0.1	2.0	-1.6	1.2	1.1	1.0	-1.9	0.2	0.6	-2.6	0.8	0.6	0.9
Number of full brothers	0.9	1.2	4.1	-2.0	-0.6	1.1	-1.3	-1.2	-1.3	-0.4	-1.0	0.3	0.9	-1.1	0.1	-1.2
Whole body fat mass	0.9	3.7	30.2	-5.5	-1.2	0.5	-1.7	-1.4	-1.4	-1.1	-1.0	0.0	1.4	-1.3	1.6	-1.2
Family relationship satisfaction	0.9	1.1	2.3	0.5	0.4	1.3	1.2	1.1	1.0	1.2	1.2	1.3	0.6	1.0	1.5	0.8
Arm fat mass (left)	0.9	3.8	31.4	-5.6	-1.1	0.6	-1.5	-1.1	-1.2	-0.9	-0.7	0.3	1.6	-1.1	2.3	-1.0
Eye problems/disorders: Glaucoma	0.9	1.1	5.1	1.2	0.3	-1.9	0.7	0.6	0.5	-1.6	0.1	0.0	-2.3	0.5	-0.1	0.4
High cholesterol (Self-reported)	0.9	1.5	12.3	-3.5	-0.8	-0.1	-0.6	-1.1	-0.8	-0.1	-0.8	-0.8	1.0	-0.8	0.0	-1.1
Myopia	0.9	1.4	2.5	-0.5	1.4	-0.2	1.2	1.6	1.4	-0.6	1.5	0.9	-0.6	1.5	1.1	1.5
Pain experienced in last month	0.9	1.5	6.8	2.6	0.8	-2.0	0.6	0.6	0.8	-1.0	0.2	-0.2	-2.0	0.6	-0.9	0.6
Heart disease (siblings)	0.9	1.2	4.8	-2.2	-0.7	0.7	-1.0	-1.2	-1.2	0.0	-1.0	-0.1	1.0	-1.1	0.5	-1.4
Pack years of smoking	0.9	1.4	4.4	-2.1	-0.5	0.3	-1.7	-1.3	-1.4	-1.1	-1.4	-0.3	0.1	-1.3	-0.5	-1.2
Major Depression (MDD)	0.8	1.0	3.4	0.1	-1.6	-0.8	-1.0	-0.7	-0.8	-0.1	-0.8	-1.8	-0.2	-0.8	-1.6	-0.7
Age at First Birth	0.8	1.2	3.3	0.7	1.7	-1.2	0.9	1.0	0.0	-1.7	0.2	0.6	-1.8	1.0	0.5	0.9
HbA1C	0.8	0.9	2.0	0.5	1.4	-0.0	1.1	0.9	0.0	0.1	1.0	1.4	-0.2	1.3	1.0	1.1
Sensitivity / hurt feelings	0.8	1.4	3.6	0.8	-0.9	1.4	-1.1	-1.4	-1.2	1.6	-1.0	-0.0	1.9	-1.2	0.1	-1.2
Impedance of leg (right)	0.8	3.6	12.8	1.5	-0.2	-3.0	-0.1	-0.4	-0.1	-2.3	-1.5	-1.8	-3.5	-0.3	-3.6	-0.7
Trunk fat percentage	0.8	3.1	26.3	-5.1	-1.0	-0.2	-1.4	-1.2	-1.2	-1.7	-1.1	-0.3	0.3	-1.1	1.1	-1.1
Fed-up feelings	0.8	1.5	3.9	0.2	-1.2	1.3	-1.5	-1.3	-1.5	1.1	-1.0	-0.6	2.0	-1.5	-0.2	-1.4
Trunk fat mass	0.8	3.3	27.7	-5.3	-1.1	0.4	-1.5	-1.2	-1.2	-1.2	-1.0	0.1	1.0	-1.1	1.5	-1.1
Past tobacco smoking	0.8	1.5	6.3	2.5	1.1	-1.5	1.1	1.1	0.9	-0.5	0.9	0.0	-1.7	0.9	0.0	1.2
Arm fat percentage (right)	0.8	3.3	29.4	-5.4	-1.1	0.0	-1.3	-1.1	-1.1	-1.3	-0.8	-0.0	0.9	-1.0	1.9	-1.0
Pulse rate	0.8	1.4	2.4	0.6	1.6	-0.4	1.1	1.3	1.2	-0.9	1.1	1.4	-1.4	1.1	1.4	1.4
Prospective memory result	0.8	1.0	4.3	0.9	0.1	-2.0	0.9	0.8	0.6	-0.7	0.4	-0.4	-2.1	0.6	-0.3	0.6
Breastfed as a baby	0.8	1.0	2.4	-1.6	-0.7	-1.2	-0.9	-1.1	-0.8	-1.1	-1.0	-0.9	-0.6	-0.9	-1.1	-1.1
Medication: Paracetamol	0.8	1.4	7.7	-2.8	-0.5	-0.3	-1.1	-1.1	-1.3	-0.9	-1.3	-0.5	0.1	-1.2	-0.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	1.1	-0.5	1.1	-1.6	-1.3	-1.4	0.2	-1.4	0.1	0.3	-1.4	-1.5	-1.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.7	-1.9	-0.9	0.3	-1.0	-1.1	-0.8	0.2	-0.9	-0.8	0.6	-0.8	-1.3	-1.0
Hypertension (Self-reported)	0.8	2.4	18.3	-4.3	-1.2	-0.2	-1.0	-1.4	-1.0	-0.7	-1.3	-0.6	1.1	-0.9	0.8	-1.3
Smoking status: Previous	0.8	1.2	5.1	-2.3	-0.7	1.2	-1.3	-1.1	-1.0	0.0	-0.9	-0.2	1.3	-1.0	-0.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	-0.3	-0.9	0.4	-1.1	-1.2	-0.9	-0.2	-1.4	-0.6	0.4	-1.0	-1.4	-1.2
Back pain experienced in last month	0.8	1.2	4.1	0.2	1.4	2.0	0.4	0.7	0.6	1.1	1.0	1.6	0.9	0.7	1.1	0.9
Osteoporosis (self-reported)	0.8	1.0	2.8	-1.7	1.4	-0.1	0.4	0.8	0.8	-1.6	-0.1	1.1	-1.1	0.8	0.1	0.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.5	-1.1	-1.6	0.0	-0.9	-1.1	-1.1	0.6	-0.9	-0.9	0.9	-1.1	-0.4	-1.2
Ever depressed for a whole week	0.8	0.9	2.2	-0.1	-1.5	-0.3	-0.6	-1.0	-0.8	0.6	-1.1	-1.4	1.0	-0.7	-1.2	-1.1
Impedance of whole body	0.8	4.3	19.3	2.5	0.8	-3.0	1.0	0.7	0.9	-2.4	-0.5	-1.4	-4.4	0.6	-3.1	0.4
Bipolar Disorder (2018)	0.7	1.1	2.2	-1.1	-0.9	0.1	-1.1	-1.4	-0.9	0.6	-1.3	-0.5	1.5	-0.8	-1.2	-1.3
Intelligence (Savage-Jansen 2018)	0.7	2.3	8.6	0.9	0.2	2.9	0.5	0.7	0.4	2.9	1.6	0.7	2.5	0.4	0.9	0.6
Mean Putamen Volume	0.7	0.8	1.5	-0.5	-0.9	0.6	-1.2	-1.2	-1.2	-0.3	-1.1	-0.4	0.7	-1.1	-0.7	-1.2
Rheumatoid Arthritis	0.7	0.9	4.2	-0.7	0.0	-2.0	1.0	0.5	0.8	-1.2	-0.0	-0.5	-1.7	0.7	-0.2	0.3
Smoking Status	0.7	1.7	9.7	-3.1	-0.9	1.6	-1.2	-1.1	-0.9	0.1	-0.9	0.2	1.4	-0.8	0.5	-1.1
Respiratory disease	0.7	1.6	3.6	-1.9	-1.4	-1.9	-0.5	-0.5	-0.8	-1.3	-1.0	-1.9	-1.4	-0.7	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.7	1.4	5.0	-2.1	-1.2	-2.2	-0.0	-0.3	0.1	-1.8	-0.3	-1.2	-1.4	0.0	0.1	-0.2
Neuroticism	0.7	1.8	11.6	3.4	0.9	0.8	0.8	0.8	0.8	1.6	0.9	1.0	1.2	0.8	1.0	1.0
Average weekly spirits intake	0.7	0.9	1.8	-1.3	-1.2	-0.6	-0.8	-1.0	-0.9	-0.6	-1.0	-1.3	-0.2	-0.9	-1.0	-1.0
High blood pressure (mother)	0.7	1.0	4.6	-1.0	-0.7	0.6	-1.1	-1.2	-1.0	1.1	-0.6	-0.2	2.1	-0.9	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.6	0.2	-1.2	0.1	-1.5	-1.3	-1.5	-0.4	-1.5	-1.7	-0.0	-1.5	-2.1	-1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.5	-0.5	-1.6	0.0	-0.5	-0.8	-0.7	1.2	-0.9	-1.0	1.6	-0.7	-0.6	-1.0
Mouth/teeth dental problems	0.7	1.0	2.3	1.5	0.7	0.5	1.3	0.9	1.3	1.0	0.8	1.3	0.3	1.2	0.6	0.9
Diabetes (self-reported)	0.7	1.0	4.1	-1.5	-0.7	-2.0	0.8	0.6	0.8	-1.1	0.5	-0.9	-1.3	0.7	0.3	0.5
Weight	0.7	3.5	25.8	-5.1	-0.8	1.4	-1.1	-0.8	-0.8	-0.2	-0.1	1.1	2.3	-0.7	2.6	-0.6
Tense / ‘highly strung’	0.7	1.2	7.4	2.7	0.7	-1.0	1.3	1.1	1.0	-0.1	0.6	-0.2	-0.7	1.1	0.5	1.0
Peak expiratory flow (PEF)	0.7	1.6	4.1	2.0	0.4	1.5	1.3	1.3	1.6	1.2	1.5	0.7	0.3	1.6	0.2	1.4
Pulse wave reflection index	0.7	0.9	1.7	-1.3	-0.6	-0.9	-1.1	-1.0	-1.0	-1.0	-0.9	-1.0	0.0	-1.0	-0.5	-1.0
Arm fat-free mass (right)	0.7	3.7	12.7	-3.5	-1.1	2.7	-1.6	-1.2	-1.2	1.2	-0.2	1.3	3.6	-1.0	2.1	-0.9
Age at first live birth	0.7	1.2	3.7	1.1	-0.6	-1.9	0.1	-0.3	-0.1	-1.4	-0.7	-1.5	-1.9	-0.3	-1.5	-0.5
Pulse wave peak to peak time	0.7	0.8	3.1	1.8	-0.4	1.5	0.4	0.3	0.4	1.7	0.5	0.4	0.9	0.4	-0.3	0.4
Arm predicted mass (right)	0.7	3.5	12.5	-3.5	-0.9	2.5	-1.4	-1.0	-1.0	1.2	-0.1	1.5	3.5	-0.8	2.3	-0.7
Suffer from ‘nerves’	0.7	1.1	3.9	1.1	-0.1	1.9	-0.1	-0.5	-0.3	2.0	-0.4	0.6	2.0	-0.2	-0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.0	1.4	1.4	0.4	0.9	0.8	1.0	0.3	0.8	1.2	0.2	1.0	0.8	1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.1	-0.4	-0.1	1.6	0.2	0.2	0.1	1.4	0.5	0.6	1.8	0.2	1.3	0.2
Commuting to job workplace: Walk	0.7	0.7	1.5	0.5	-1.0	-0.5	-1.1	-1.0	-0.8	0.2	-1.2	-0.1	0.9	-0.7	-1.2	-0.8
Osteoarthritis (self-reported)	0.7	0.9	5.4	-0.5	-0.4	-2.3	-0.3	-0.5	-0.6	-1.2	-0.9	-0.5	-1.4	-0.6	-0.3	-0.6
Smoking status: Current	0.7	1.1	3.8	-1.6	-1.9	0.5	-0.9	-1.0	-1.0	0.5	-0.8	-1.0	0.9	-1.0	-0.5	-1.1
Arm predicted mass (left)	0.7	3.5	12.7	-3.6	-0.6	2.7	-1.0	-0.6	-0.5	1.3	0.3	1.7	3.4	-0.4	2.7	-0.3
Neuroticism (Nagel 2018)	0.6	1.3	10.4	3.2	0.7	0.4	0.9	0.9	0.7	1.3	0.7	0.5	0.4	0.7	0.5	0.8
Reaction Time	0.6	1.2	5.2	-1.3	-0.5	-2.3	-0.2	-0.1	-0.3	-2.0	-0.7	-1.1	-1.6	-0.2	-0.2	-0.1
Breast Cancer	0.6	1.5	5.8	-1.5	1.5	0.1	0.7	0.9	0.8	-1.0	0.8	2.0	-0.5	0.9	2.4	1.0
Crohns Disease (2012)	0.6	1.0	4.7	-0.3	-1.3	-0.3	-0.5	-0.8	-0.5	0.7	-1.0	-1.4	0.5	-0.5	-2.2	-0.8
Systolic blood pressure, automated reading	0.6	1.7	8.3	-1.6	-0.1	1.2	-0.5	-0.8	-0.8	1.6	-0.2	1.0	2.9	-0.5	1.9	-0.7
Medication: Co-codamol	0.6	0.7	4.2	-2.0	0.2	-0.7	-0.9	-1.1	-0.8	-0.5	-1.0	-0.0	0.2	-0.7	-0.3	-0.8
Diabetes (father)	0.6	0.7	2.5	1.6	0.6	0.3	0.6	0.6	0.9	0.7	0.7	1.2	0.5	0.9	0.7	0.8
Current tobacco smoking	0.6	1.0	3.5	-1.7	-1.9	0.5	-0.8	-0.8	-0.9	0.4	-0.7	-0.9	0.9	-0.9	-0.3	-1.0
Maternal smoking around birth	0.6	0.8	2.3	-0.4	-0.8	1.4	-1.1	-0.9	-0.7	1.0	-0.6	-0.3	1.5	-0.8	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.3	-0.2	0.5	-0.7	1.0	1.1	1.0	-0.4	0.7	0.5	-0.7	1.0	0.7	1.1
Medication: Levothyroxine sodium	0.6	1.0	4.7	-0.6	1.0	-1.8	0.4	0.4	0.2	-1.8	-0.5	-0.1	-2.2	-0.0	-0.1	0.1
Impedance of leg (left)	0.6	3.0	11.7	1.8	0.1	-2.7	0.4	0.0	0.3	-2.0	-1.0	-1.4	-3.4	0.1	-3.0	-0.2
Pain all over the body in last month	0.6	0.6	1.8	-1.3	-1.1	0.5	-0.8	-0.6	-0.8	0.3	-0.3	-0.9	1.0	-0.7	0.1	-0.7
Father’s age at death	0.6	0.8	5.8	2.4	-0.4	-0.4	0.9	0.5	0.8	1.0	0.7	0.1	0.2	0.7	0.0	0.5
Asthma	0.6	1.2	3.3	-1.8	-1.2	-1.3	-0.8	-0.8	-0.9	-0.8	-1.0	-1.7	-0.6	-0.9	-0.9	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	-1.6	0.6	-1.4	-0.2	-0.1	-0.2	-1.7	-0.3	-0.2	-1.0	-0.2	0.4	-0.2
Headache pain in last month	0.6	1.1	4.8	-0.7	-0.2	2.2	-0.0	-0.0	-0.1	1.7	0.5	0.4	2.1	-0.1	0.8	0.0
Medication: Amlodipine	0.6	0.8	3.8	-0.8	-0.8	-1.9	-0.2	-0.4	-0.4	-1.4	-0.5	-1.3	-1.0	-0.4	-0.6	-0.4
Overall health rating	0.6	1.3	8.4	-2.9	0.1	1.3	-0.0	-0.2	-0.0	0.9	0.4	1.2	1.5	0.1	1.7	0.0
Age at last live birth	0.6	0.9	2.0	0.1	-1.1	-0.2	-0.9	-1.2	-0.9	-0.3	-1.2	-1.2	0.1	-1.0	-1.4	-1.2
Leg pain on walking	0.6	0.8	4.5	-0.5	-1.0	-2.1	0.0	-0.2	-0.0	-1.4	-0.8	-1.0	-1.0	0.0	0.3	-0.1
Leg fat-free mass (right)	0.6	3.1	10.2	-2.5	-0.3	2.9	-0.5	-0.0	-0.1	1.6	0.9	1.7	3.2	0.0	2.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.7	0.1	-0.3	1.3	0.1	-0.4	-0.4	1.9	0.1	-0.3	1.4	-0.3	-0.5	-0.4
Leg predicted mass (right)	0.6	3.0	9.8	-2.5	-0.2	2.9	-0.4	0.0	-0.1	1.5	1.0	1.7	3.1	0.1	3.0	0.3
Mother’s age at death	0.6	0.8	3.5	-0.1	0.3	-1.9	0.2	0.2	-0.2	-1.7	-0.2	-0.6	-1.8	-0.1	-0.1	0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	4.3	-1.3	-0.4	-0.9	-0.7	-0.5	-0.5	-2.1	-0.6	-0.6	-0.5	-0.4	0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.3	1.8	1.4	0.4	0.7	0.8	0.7	0.5	0.6	1.2	-0.2	0.7	0.5	0.7
Arm fat-free mass (left)	0.6	3.2	13.2	-3.6	-0.7	2.4	-1.1	-0.7	-0.7	1.0	0.0	1.5	3.1	-0.6	2.5	-0.5
Age started oral contraceptive pill	0.6	0.7	3.0	0.6	0.8	0.2	0.7	0.5	0.5	0.9	0.6	1.3	0.9	0.7	1.7	0.5
Alcohol drinker status: Previous	0.6	0.7	2.6	-1.6	-0.9	0.1	-0.8	-0.9	-0.7	0.1	-0.8	-0.6	0.8	-0.8	0.3	-0.9
Schizophrenia (2018)	0.5	1.1	3.5	0.8	0.7	-1.9	0.9	0.9	0.8	-1.1	0.2	-0.2	-1.8	0.8	-0.9	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	5.9	2.4	1.1	-0.2	0.2	0.2	0.1	0.2	0.2	0.3	-0.6	0.1	-0.3	0.2
Crohns Disease (2017)	0.5	1.1	2.8	-0.3	-1.1	0.5	-0.7	-1.2	-0.7	1.5	-1.3	-0.4	1.7	-0.6	-1.4	-1.1
Ulcerative Colitis (UC)	0.5	0.9	1.9	1.4	0.5	-0.7	1.1	1.4	0.9	0.5	1.3	0.1	-0.5	1.0	-0.1	1.2
Primary Biliary Cirrhosis	0.5	0.7	1.9	-1.1	-0.1	1.4	-0.8	-0.5	-0.6	0.4	-0.3	1.1	1.4	-0.6	0.8	-0.5
Ulcerative Colitis	0.5	0.7	1.7	0.6	-0.5	-1.3	0.8	1.2	0.7	0.0	0.8	-1.1	-0.8	0.6	-0.2	0.8
Systolic Blood Pressure	0.5	2.3	11.8	-0.7	-1.2	2.1	-0.2	-0.8	-0.5	2.9	-0.1	0.7	3.4	-0.3	0.9	-0.7
Hypothyroidism (self reported)	0.5	1.1	5.6	-0.1	1.1	-1.6	0.5	0.3	0.3	-1.8	-0.7	-0.1	-2.4	0.1	-0.5	0.1
Chronotype (morning person)	0.5	1.2	4.4	0.8	0.6	-0.0	1.3	1.4	1.1	-0.2	1.5	0.5	-0.6	1.1	2.1	1.3
Severe depression (siblings)	0.5	0.5	0.9	-0.1	-0.9	-0.4	-0.4	-0.9	-0.7	0.9	-0.8	-0.6	0.7	-0.8	-0.7	-0.9
Leg fat-free mass (left)	0.5	2.8	9.2	-3.0	-0.6	2.5	-0.9	-0.5	-0.5	1.1	0.4	1.4	3.0	-0.3	2.5	-0.2
Sitting height	0.5	3.3	8.4	2.0	1.4	2.7	1.1	0.9	1.3	2.9	1.3	2.5	2.2	1.2	0.9	1.1
Leg predicted mass (left)	0.5	2.9	9.8	-3.0	-0.5	2.7	-0.9	-0.5	-0.5	1.2	0.5	1.5	3.1	-0.3	2.5	-0.1
Financial difficulties in last 2 years	0.5	0.7	5.1	-2.3	0.8	0.6	0.2	0.4	0.4	0.3	0.4	1.0	0.8	0.4	0.9	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.9	1.6	-0.0	2.0	0.5	0.2	0.5	1.9	0.4	0.2	1.4	0.5	-0.6	0.3
Birth weight of first child	0.5	0.9	2.8	-0.1	0.4	1.7	0.5	0.9	0.4	1.2	1.2	0.5	1.0	0.4	1.5	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	0.3	-1.0	0.6	-0.7	-0.7	-1.0	0.6	-0.7	-0.7	0.5	-1.0	-1.0	-1.0
Loud music exposure frequency	0.5	0.6	2.0	-0.9	0.3	1.1	0.2	-0.1	0.1	1.1	0.1	1.2	1.4	0.2	0.8	-0.1
Eye problems/disorders: None of the above	0.5	0.6	2.6	-0.3	-0.6	1.3	-0.6	-0.4	-0.7	1.2	0.2	-0.5	1.6	-0.6	0.2	-0.4
Medication: Blood pressure	0.5	1.0	2.0	-1.0	0.2	-1.2	1.3	1.1	1.1	-0.6	1.0	-0.3	-0.5	1.1	1.4	1.0
Alcohol intake frequency.	0.5	1.2	7.6	-2.7	0.5	-0.4	0.4	0.4	0.3	-1.2	0.1	0.8	-0.2	0.4	2.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.5	1.9	0.1	0.1	0.6	0.6	0.4	1.3	0.8	0.4	0.4	0.4	0.3	0.6
Whole body fat-free mass	0.5	3.0	11.2	-2.6	-0.4	2.8	-0.7	-0.4	-0.4	1.5	0.5	1.8	3.3	-0.2	2.5	-0.1
Qualifications: nursing, teaching	0.5	0.8	2.0	1.4	0.8	0.2	1.3	1.0	1.0	1.3	0.8	0.3	-0.3	1.0	-0.5	0.9
Mineral and other dietary supplements	0.5	0.6	1.6	-0.5	0.2	-0.6	1.0	0.9	1.0	-0.6	0.8	0.4	-0.7	0.9	1.3	0.9
Whole body water mass	0.5	2.9	10.2	-2.6	-0.4	2.7	-0.7	-0.4	-0.4	1.4	0.5	1.8	3.2	-0.2	2.6	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	5.2	-2.3	0.3	-1.7	0.0	-0.3	-0.1	-1.4	-0.4	-0.1	-1.0	-0.0	0.5	-0.2
Hearing aid user	0.5	0.5	1.1	-0.9	-0.2	0.7	-0.9	-0.6	-1.1	-0.4	-0.4	0.0	0.3	-1.0	0.9	-0.8
Medication: Paracetamol	0.5	0.8	4.0	-2.0	0.1	0.8	-0.9	-0.7	-0.9	0.2	-0.6	0.6	1.0	-0.8	0.6	-0.6
Alcohol drinker status: Never	0.5	0.6	1.9	-1.2	-0.4	-0.2	-0.9	-1.1	-0.8	-0.4	-1.4	0.2	0.4	-0.7	-0.3	-1.0
Basal metabolic rate	0.5	2.9	11.5	-3.4	-0.6	2.5	-0.9	-0.6	-0.6	1.0	0.3	1.5	3.0	-0.4	2.5	-0.3
Number of operations (self-reported)	0.5	0.8	1.8	-0.8	0.9	0.2	1.3	1.1	1.2	0.1	0.9	0.9	-0.5	1.2	0.9	0.9
Average weekly beer plus cider intake	0.5	0.7	1.3	0.8	1.0	-0.1	1.0	1.2	1.1	-0.1	0.8	0.4	-0.7	1.0	0.4	1.1
Diastolic blood pressure, automated reading	0.5	1.7	11.1	-3.3	0.5	0.9	-0.3	-0.1	-0.3	0.2	0.3	1.3	1.4	-0.2	2.4	0.0
Supplements: Calcium	0.5	0.6	3.4	-0.0	-0.5	1.2	0.0	-0.1	-0.1	1.6	0.1	0.3	1.8	0.1	-0.0	-0.1
Fasting Glucose	0.4	0.5	2.4	-0.1	0.8	-0.0	0.7	0.8	0.0	0.1	0.8	0.8	0.0	0.8	1.6	0.8
Hand grip strength (left)	0.4	1.2	5.0	-1.7	0.2	1.1	0.8	0.8	0.7	0.3	1.2	0.8	1.0	0.8	2.2	0.8
Ever had hysterectomy (womb removed)	0.4	0.5	3.3	-1.8	-0.1	0.3	-0.3	-0.3	-0.5	-0.4	-0.4	0.3	0.2	-0.5	1.0	-0.6
Pack years adult smoking proportion	0.4	0.7	2.6	-1.6	-0.2	0.5	-1.3	-0.8	-1.0	-0.7	-0.8	0.1	0.2	-0.9	-0.2	-0.7
Age when periods started (menarche)	0.4	0.9	2.5	1.6	0.6	0.6	1.0	1.1	1.1	0.7	1.3	0.8	0.1	1.0	0.9	1.1
Medication: Atenolol	0.4	0.5	1.4	-1.0	1.2	0.1	0.7	0.4	0.6	-0.3	0.0	0.9	-0.1	0.6	1.0	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	2.5	-1.6	0.3	1.1	-0.8	-0.3	-0.7	0.0	-0.1	-0.4	0.4	-0.7	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.3	1.2	-0.2	1.1	0.4	0.4	0.2	1.5	0.3	0.2	1.2	0.3	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.5	1.4	0.1	-1.0	-0.2	-0.1	-0.1	0.1	-0.2	-0.4	-0.6	-0.2	-1.6	0.0
Neuroticism score	0.4	0.8	6.4	2.5	0.2	0.6	0.1	0.2	0.1	1.4	0.3	0.3	1.2	0.1	0.5	0.3
Trunk fat-free mass	0.4	2.3	8.8	-2.2	-0.3	2.5	-0.6	-0.3	-0.3	1.4	0.5	1.8	3.0	-0.1	2.2	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.0	0.6	1.1	0.5	0.7	0.7	0.6	1.2	0.7	0.8	0.7	1.1	0.8
Number of live births	0.4	0.5	1.9	-0.6	-0.0	0.3	-1.4	-0.8	-1.0	-0.7	-0.6	-0.2	0.5	-1.0	0.2	-0.7
Noisy workplace	0.4	0.5	1.2	1.1	0.7	-0.6	0.8	0.7	0.7	0.4	0.7	0.9	0.1	0.8	0.9	0.7
Medication: Lansoprazole	0.4	0.4	1.1	-0.7	-1.0	-0.1	-0.8	-0.6	-0.9	-0.0	-0.5	-1.0	0.3	-0.8	-0.3	-0.6
Trunk predicted mass	0.4	2.3	8.3	-2.1	-0.1	2.5	-0.4	-0.2	-0.1	1.3	0.6	1.8	2.9	-0.0	2.4	0.1
Exposure to tobacco smoke at home	0.4	0.5	1.6	-1.3	-0.1	0.7	-0.8	-0.7	-0.8	0.3	-0.7	0.1	0.7	-0.8	0.1	-0.8
Hair/balding pattern: Pattern 4	0.4	1.1	3.9	-1.1	-1.2	-2.0	-0.3	-0.6	-0.6	-0.9	-0.9	-1.7	-0.9	-0.5	-1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	3.0	0.8	0.2	1.7	-0.0	0.1	0.1	1.7	0.4	0.4	1.4	0.1	-0.5	0.3
Comparative body size at age 10	0.4	1.2	8.8	-3.0	-0.4	0.8	-1.0	-0.8	-0.5	-0.1	-0.4	0.2	1.6	-0.4	1.0	-0.5
Worry too long after embarrassment	0.4	0.7	2.3	1.5	0.3	0.5	1.0	0.6	0.7	1.2	0.8	0.4	0.8	0.8	0.6	0.6
Health satisfaction	0.4	0.5	2.9	-1.7	-0.6	-0.6	0.1	-0.1	0.2	-1.3	-0.4	-0.1	-0.8	0.2	0.4	-0.1
Medication: Allopurinol	0.4	0.5	2.5	1.6	0.8	-0.1	0.5	0.5	0.5	0.0	0.1	0.2	-0.8	0.5	-1.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	0.3	0.3	1.1	0.0	0.3	0.2	0.9	0.4	1.3	0.9	0.2	1.4	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-0.2	-0.3	1.3	-0.7	-0.5	-0.7	1.0	-0.1	-0.6	1.0	-0.7	-0.2	-0.5
Diabetes diagnosed by doctor	0.4	0.6	2.9	-1.7	-0.6	-1.4	0.6	0.4	0.6	-0.7	0.4	-0.7	-0.8	0.5	0.3	0.3
Breast cancer (self-reported)	0.4	0.4	2.9	-0.2	-0.3	-1.7	-0.2	-0.3	-0.4	-0.9	-0.5	-0.4	-0.9	-0.4	-0.2	-0.4
Asthma (self-reported)	0.4	0.8	2.3	-1.5	-1.1	-1.2	-0.4	-0.5	-0.7	-0.7	-0.7	-1.5	-0.7	-0.7	-0.7	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	0.4	-0.4	-1.2	0.3	0.1	0.0	-1.3	-0.5	-0.5	-1.4	0.1	-0.5	-0.1
Miserableness	0.4	0.7	1.4	-0.0	-0.8	0.7	-1.1	-0.9	-1.0	0.2	-0.8	-0.6	1.2	-1.0	-0.1	-1.0
Financial situation satisfaction	0.4	0.4	1.2	-0.6	0.2	1.0	0.3	0.6	0.1	1.1	0.7	0.5	1.0	0.2	1.0	0.3
Commuting to job workplace: Public transport	0.4	0.4	1.5	-1.2	-0.4	-0.5	-0.5	-0.8	-0.4	-0.8	-1.0	-0.2	0.1	-0.4	-0.5	-0.7
Medication: Lisinopril	0.4	0.6	1.9	-0.3	0.9	-0.0	0.7	0.5	0.9	0.0	0.7	1.0	0.2	0.9	1.4	0.8
Irritability	0.4	0.7	6.7	2.6	-0.1	0.4	-0.0	0.2	0.0	1.3	0.2	-0.3	0.7	0.1	-0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.6	0.5	0.1	1.0	-0.1	-0.2	-0.4	1.6	0.2	0.4	1.4	-0.4	0.3	-0.3
Blood White Count	0.3	1.9	9.4	3.1	-1.7	0.7	-1.0	-0.9	-0.5	2.0	-0.3	-0.6	1.9	-0.5	-1.1	-0.4
Waist Hip Ratio (WHR)	0.3	1.5	6.4	1.2	0.1	-2.5	0.6	0.2	0.3	-1.4	-0.3	-0.8	-2.5	0.1	-1.6	0.1
Number of treatments/medications taken	0.3	0.6	3.5	-1.9	0.9	-0.2	0.3	0.1	0.3	-0.6	0.0	1.0	0.1	0.4	1.1	0.2
Taking other prescription medications	0.3	0.4	1.8	-1.3	1.1	-0.4	0.3	0.0	0.3	-0.8	-0.2	0.8	-0.9	0.4	0.2	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	1.1	-0.8	-0.1	-0.8	-0.8	-0.8	0.8	-0.5	-0.9	0.7	-0.8	-1.4	-0.7
Stomach or abdominal pain in last month	0.3	0.4	2.2	0.4	-0.2	1.1	0.0	-0.2	-0.3	1.5	0.2	-0.1	1.1	-0.2	-0.1	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.2	0.2	0.4	0.8	0.6	0.7	0.7	1.1	0.8	1.0	0.6	0.7	0.7	0.7
Had other major operations	0.3	0.4	3.5	-1.9	0.3	0.6	-0.2	-0.2	-0.4	-0.2	-0.2	0.1	-0.1	-0.4	-0.0	-0.3
Worrier / anxious feelings	0.3	0.5	4.4	2.1	0.1	-0.1	0.4	0.2	0.2	1.1	0.2	-0.1	0.5	0.3	0.1	0.2
Depression (self-reported)	0.3	0.3	1.5	0.2	-0.5	0.7	0.0	-0.3	-0.0	1.2	0.2	0.0	1.2	-0.1	0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.2	0.7	0.3	0.4	0.9	0.6	-0.3	0.9	0.3	-0.0	0.7	0.7	0.9
Gout (self-reported)	0.3	0.4	1.4	1.1	1.2	0.4	0.6	0.6	0.5	-0.4	0.3	0.8	-0.6	0.4	0.1	0.6
Exposure to tobacco smoke outside home	0.3	0.4	1.9	-1.4	0.7	1.0	0.2	0.2	0.1	0.4	0.1	0.9	0.3	0.1	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-0.9	-0.9	-0.4	-0.8	-0.6	0.3	-0.7	-1.0	0.6	-0.6	-0.1	-0.7
Qualifications: College or University degree	0.3	0.9	5.9	2.4	-0.2	1.2	0.4	0.3	0.3	1.8	0.6	-0.1	0.8	0.2	-0.6	0.2
Medication: Seretide 50 evohaler	0.3	0.3	1.5	-0.4	-0.9	0.0	-0.1	-0.3	-0.2	0.6	-0.5	-1.0	0.1	-0.2	-1.2	-0.2
Heart disease (mother)	0.3	0.3	1.1	0.4	1.1	0.7	0.4	0.3	0.4	0.6	0.3	0.9	0.3	0.4	0.1	0.3
Pulse rate, automated reading	0.3	1.0	2.2	-0.3	0.5	1.3	0.2	0.7	0.6	1.2	1.1	1.4	1.4	0.6	1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.9	0.6	-1.4	0.6	-0.7	-0.7	-0.6	1.1	-0.3	-0.6	1.2	-0.7	-0.9	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	2.2	-1.5	-0.6	-0.6	-0.6	-0.7	-0.8	-0.1	-0.6	-0.7	-0.0	-0.8	-0.1	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.3	0.5	0.4	-0.8	0.6	0.5	0.6	-0.7	0.2	0.1	-1.1	0.6	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	2.2	-0.1	-0.0	-1.4	0.0	-0.1	0.1	-0.4	-0.7	-0.5	-0.5	0.1	-1.5	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.7	-0.5	-0.7	-0.7	-0.6	-0.8	-0.6	-0.8	-0.9	-0.1	-0.8	-0.3	-0.7
HDL Cholesterol	0.2	0.3	2.3	1.5	0.2	-0.6	0.5	0.4	0.0	0.2	0.3	-0.6	-0.5	0.4	-0.5	0.4
Schizophrenia (2014)	0.2	0.4	1.3	0.6	0.5	-1.0	0.4	0.5	0.4	-0.7	-0.1	0.0	-1.1	0.4	-0.8	0.3
Heel T-Score	0.2	1.6	9.6	3.1	-0.7	0.1	-0.4	-0.8	-0.4	1.3	-0.9	-0.9	0.4	-0.5	-2.4	-0.7
Tanning	0.2	1.9	3.7	1.9	1.7	1.9	0.8	1.1	0.8	1.4	1.8	1.6	0.8	0.8	1.4	1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.1	1.0	0.2	0.2	0.1	-0.2	0.0	0.3	0.8	-0.6	-0.2	0.9	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.6	0.1	-0.4	0.5	0.3	0.1	0.3	1.3	0.4	0.0	0.8	0.4	-0.3	0.2
Supplements: Zinc	0.2	0.2	1.1	1.1	0.1	0.3	-0.1	-0.1	-0.1	0.9	0.2	0.1	0.6	-0.0	-0.3	0.0
Diabetes (mother)	0.2	0.2	1.9	-1.4	-0.3	-0.1	0.1	0.1	-0.0	0.0	0.0	0.4	0.5	0.0	0.7	-0.1
Hand grip strength (right)	0.2	0.5	1.4	-1.2	-0.3	1.2	0.2	0.3	0.2	0.5	0.9	0.0	1.2	0.4	1.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-0.6	-1.0	-0.1	-0.2	-0.1	-0.5	0.5	-0.0	-0.9	0.6	-0.5	0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.5	-0.4	0.6	-0.3	-0.3	-0.3	0.6	-0.1	-0.2	0.8	-0.3	0.1	-0.3
Allergy	0.2	0.5	1.2	0.0	0.9	0.2	0.9	0.8	0.8	-0.6	0.6	0.8	-0.7	0.8	1.1	0.7
Standing height	0.2	1.5	2.6	1.6	1.3	0.4	1.4	1.4	1.6	-0.1	1.3	1.5	-0.7	1.5	0.4	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.6	-0.5	0.3	-0.4	-0.4	-0.2	0.3	-0.4	0.2	0.9	-0.3	0.2	-0.4
Migraine (self-reported)	0.2	0.2	0.6	-0.1	0.8	-0.8	0.6	0.5	0.6	0.1	0.4	-0.1	-0.0	0.6	-0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	-0.9	-0.6	0.6	-0.1	0.0	-0.1	0.4	0.5	0.1	0.7	0.0	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.3	-1.1	-0.1	0.7	-0.7	-0.5	-0.5	-0.0	-0.2	0.2	0.5	-0.5	0.2	-0.4
Wears glasses or contact lenses	0.2	0.3	0.9	0.1	-0.0	-0.6	0.2	0.6	0.3	-1.0	0.3	-0.4	-0.6	0.5	0.6	0.5
Ever taken oral contraceptive pill	0.2	0.2	1.1	0.3	0.6	1.1	-0.3	-0.2	0.1	0.3	-0.1	0.9	0.3	0.0	-0.1	0.1
Risk taking	0.2	0.3	2.0	-1.4	-0.6	-0.4	-0.1	-0.0	-0.3	-0.4	-0.1	-0.6	-0.4	-0.3	-0.3	-0.3
Irritable Bowel Disease (IBD)	0.1	0.3	1.6	0.8	-0.4	-0.1	0.2	0.1	0.1	1.3	0.0	-0.3	0.8	0.3	-1.0	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.7	-0.3	-0.4	-0.4	-0.2	-0.1	0.0	-0.1	-0.2	-0.8	-0.1	-0.1	-0.8	-0.1
Neuroticism (2016)	0.1	0.2	0.8	0.9	-0.4	-0.8	0.3	-0.1	-0.0	0.1	-0.5	-0.0	0.1	0.1	0.0	-0.3
Blood Eosinophil Count	0.1	0.7	3.8	2.0	-0.1	-0.8	0.4	0.6	0.3	0.4	0.3	-1.2	-1.0	0.1	-1.4	0.2
Height	0.1	1.4	7.8	-0.7	-0.0	-1.5	0.4	0.4	0.9	-2.8	-0.0	-0.1	-2.2	0.8	-0.8	0.4
Allergy or Eczema	0.1	0.2	1.3	1.2	0.1	-0.4	0.2	0.3	0.1	0.3	0.3	-0.2	-0.4	0.2	-0.6	0.3
Hair Pigment	0.1	4.0	9.7	-0.2	-2.0	-1.9	-2.0	-2.2	-1.9	-1.2	-2.6	-2.2	-0.5	-2.0	-3.1	-2.2
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	0.5	0.6	-0.3	-0.3	-0.4	-0.1	-0.1	0.4	-0.3	-0.4	-0.2	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.6	-0.5	-0.2	-0.2	0.7	0.3	0.3	0.6	0.3	0.2	0.2	0.3	0.8	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.2	0.2	0.5	0.1	0.5	0.4	-0.5	0.3	0.3	-0.3	0.3	0.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.3	-0.2	-0.6	0.1	-0.2	0.0	0.6	-0.3	-0.3	0.6	0.0	-0.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.3	0.5	-0.4	0.4	0.3	0.3	-0.5	0.2	0.2	-0.4	0.3	0.6	0.4
Medication: Ibuprofen	0.1	0.1	0.4	-0.3	-0.4	0.5	-0.6	-0.2	-0.3	-0.4	-0.3	-0.2	0.1	-0.4	0.1	-0.2
Comparative height size at age 10	0.1	0.6	3.0	-0.5	-0.7	-0.0	-0.8	-0.8	-0.6	-0.3	-0.9	-0.6	-0.4	-0.7	-1.7	-0.8
Supplements: Vitamin C	0.1	0.2	0.6	0.5	0.3	-0.0	-0.2	-0.4	-0.0	0.6	-0.3	0.5	0.8	-0.0	-0.6	-0.2
Illnesses of father: Heart disease	0.1	0.2	1.0	-0.1	-0.5	-0.2	-0.0	-0.4	-0.1	1.0	-0.3	-0.2	0.5	-0.1	-0.4	-0.2
Average weekly red wine intake	0.1	0.1	0.4	0.7	-0.0	0.6	0.1	-0.2	0.1	0.5	0.4	0.4	0.2	0.1	0.3	0.0
Loneliness, isolation	0.1	0.1	0.2	-0.2	0.2	-0.3	-0.3	-0.2	-0.4	-0.1	-0.4	-0.4	0.1	-0.3	-0.2	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.4	-0.4	-0.1	0.1	-0.1	-0.3	-0.0	0.1	-0.3	0.6	0.1	0.0	-0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	-0.5	-0.4	0.3	-0.2	-0.2	-0.0	0.4	-0.2	0.3	0.9	-0.0	0.5	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Alcohol usually taken with meals	0.0	0.1	0.3	0.6	0.1	-0.1	0.1	-0.1	0.2	0.3	0.1	0.6	0.1	0.3	-0.0	0.2

Hub : Genes

ITGAD

Models

Trait associations