[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr16:30,347,731-31,860,399

Best TWAS P=3.33e-11 · Best GWAS P=8.87e-11 conditioned to 0.166

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD3B7 0.05 0.06 lasso 4 0.07 5.5e-09 -6.3 -6.3 3.1e-10 1.00 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous KAT8 0.19 0.17 lasso 5 0.25 4.8e-20 -4.8 -5.7 1.0e-08 0.88 0.10 0.90 FALSE
3 GTEx Adipose Subcutaneous RP11-196G11.2 0.23 0.20 lasso 9 0.21 4.2e-17 -6.0 -6.2 6.5e-10 0.96 0.11 0.89 FALSE
4 GTEx Adipose Visceral Omentum RP11-196G11.2 0.08 0.07 enet 16 0.08 8.4e-05 -6.4 -5.8 7.0e-09 0.92 0.03 0.96 FALSE
5 GTEx Adrenal Gland HSD3B7 0.21 0.17 lasso 4 0.13 2.9e-05 -6.2 -5.6 2.3e-08 0.93 0.04 0.91 FALSE
6 GTEx Artery Aorta STX1B 0.17 0.18 lasso 6 0.15 1.9e-08 -6.4 -6.3 2.2e-10 0.98 0.02 0.98 FALSE
7 GTEx Artery Aorta RP11-196G11.2 0.10 0.16 lasso 2 0.14 7.1e-08 -5.9 -6.1 1.2e-09 0.95 0.04 0.96 FALSE
8 GTEx Artery Coronary RP11-196G11.2 0.12 0.06 lasso 6 0.06 3.4e-03 -6.0 -6.0 1.7e-09 0.93 0.04 0.88 FALSE
9 GTEx Artery Tibial RP11-196G11.2 0.08 0.04 lasso 4 0.03 3.8e-03 -5.9 -5.8 8.8e-09 0.94 0.04 0.95 FALSE
10 GTEx Brain Cerebellar Hemisphere STX1B 0.13 0.11 lasso 5 0.10 1.5e-03 -6.2 -6.3 3.0e-10 0.93 0.03 0.76 FALSE
11 GTEx Brain Cerebellar Hemisphere RP11-196G11.2 0.18 0.06 lasso 6 0.10 1.7e-03 -6.3 -5.8 4.8e-09 0.97 0.03 0.89 FALSE
12 GTEx Brain Cerebellum STX1B 0.24 0.16 lasso 11 0.18 4.8e-06 -6.0 -6.0 2.5e-09 0.94 0.04 0.96 FALSE
13 GTEx Brain Cerebellum STX4 0.14 0.25 lasso 1 0.24 8.3e-08 -6.2 -6.2 5.8e-10 0.94 0.05 0.94 FALSE
14 GTEx Brain Cerebellum RP11-196G11.2 0.31 0.30 lasso 4 0.36 1.3e-11 -6.2 -6.2 6.2e-10 0.96 0.06 0.94 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia STX4 0.19 0.11 enet 14 0.09 2.6e-03 -5.9 5.5 4.0e-08 -0.85 0.04 0.72 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia KAT8 0.19 0.13 lasso 4 0.18 1.4e-05 4.2 -5.2 2.2e-07 0.79 0.15 0.08 FALSE
17 GTEx Breast Mammary Tissue KAT8 0.23 0.14 lasso 10 0.17 4.4e-09 4.3 -5.6 2.4e-08 0.82 0.16 0.84 FALSE
18 GTEx Breast Mammary Tissue RP11-196G11.2 0.13 0.16 lasso 4 0.17 5.0e-09 -6.0 -5.7 1.1e-08 0.97 0.08 0.92 FALSE
19 GTEx Breast Mammary Tissue (Male) RP11-196G11.2 0.15 0.16 lasso 4 0.09 3.9e-03 -6.0 -6.0 1.9e-09 0.98 0.04 0.90 FALSE
20 GTEx Cells Transformed fibroblasts STX1B 0.12 0.10 lasso 5 0.10 6.8e-08 -5.9 -5.5 4.7e-08 0.93 0.03 0.97 FALSE
21 GTEx Cells Transformed fibroblasts HSD3B7 0.11 0.07 lasso 8 0.06 1.4e-05 -6.2 -5.4 7.2e-08 0.90 0.04 0.95 FALSE
22 GTEx Cells Transformed fibroblasts RP11-196G11.2 0.14 0.14 lasso 6 0.13 2.9e-10 -6.3 -6.3 2.7e-10 0.98 0.02 0.98 FALSE
23 GTEx Colon Sigmoid KAT8 0.20 0.10 lasso 3 0.14 1.0e-05 4.3 -5.1 2.9e-07 0.80 0.27 0.14 FALSE
24 GTEx Colon Transverse HSD3B7 0.16 0.15 enet 20 0.19 2.1e-09 -6.1 -5.4 6.6e-08 0.89 0.04 0.96 FALSE
25 GTEx Colon Transverse STX4 0.10 0.09 lasso 3 0.06 6.6e-04 -6.0 -6.0 2.1e-09 0.98 0.03 0.92 FALSE
26 GTEx Colon Transverse RP11-196G11.2 0.24 0.11 lasso 5 0.15 1.9e-07 -5.9 -6.1 1.2e-09 0.94 0.03 0.97 FALSE
27 GTEx Esophagus Gastroesophageal Junction KAT8 0.18 0.11 lasso 4 0.24 4.9e-09 -4.8 -5.6 2.0e-08 0.88 0.05 0.94 FALSE
28 GTEx Esophagus Mucosa STX1B 0.12 0.03 lasso 5 0.05 1.7e-04 -6.2 -6.1 8.9e-10 0.86 0.04 0.95 FALSE
29 GTEx Esophagus Mucosa HSD3B7 0.38 0.32 lasso 5 0.36 1.2e-24 -6.2 -5.8 7.9e-09 0.93 0.04 0.96 FALSE
30 GTEx Esophagus Mucosa STX4 0.08 0.00 enet 21 0.02 1.0e-02 -5.9 -5.5 3.7e-08 0.78 0.06 0.90 FALSE
31 GTEx Esophagus Mucosa KAT8 0.21 0.15 lasso 4 0.23 3.5e-15 -4.8 -5.2 1.7e-07 0.82 0.94 0.06 FALSE
32 GTEx Esophagus Mucosa RP11-196G11.2 0.09 0.03 enet 13 0.05 1.5e-04 -6.0 -6.1 8.7e-10 0.91 0.04 0.94 FALSE
33 GTEx Esophagus Muscularis STX4 0.05 0.05 lasso 3 0.03 6.7e-03 -5.9 -6.2 6.9e-10 0.97 0.03 0.94 FALSE
34 GTEx Esophagus Muscularis KAT8 0.29 0.19 lasso 4 0.21 1.2e-12 -4.8 -5.3 1.2e-07 0.82 0.86 0.14 FALSE
35 GTEx Esophagus Muscularis RP11-196G11.2 0.14 0.14 lasso 6 0.13 3.7e-08 -6.0 -6.0 1.7e-09 0.96 0.03 0.97 FALSE
36 GTEx Heart Left Ventricle HSD3B7 0.12 0.08 lasso 3 0.07 2.0e-04 -6.1 -6.1 8.6e-10 0.94 0.04 0.94 FALSE
37 GTEx Lung RP11-196G11.2 0.21 0.12 enet 22 0.14 1.6e-10 -6.2 -6.6 3.3e-11 0.88 0.08 0.92 TRUE
38 GTEx Muscle Skeletal HSD3B7 0.15 0.13 enet 19 0.14 5.5e-14 -6.2 -5.1 2.8e-07 0.89 0.04 0.96 FALSE
39 GTEx Muscle Skeletal STX4 0.04 0.04 lasso 3 0.03 2.9e-04 -6.4 -6.3 2.1e-10 0.98 0.02 0.97 FALSE
40 GTEx Muscle Skeletal RP11-196G11.2 0.15 0.10 enet 10 0.12 1.0e-11 -6.0 -6.0 1.6e-09 0.95 0.03 0.97 FALSE
41 GTEx Nerve Tibial STX1B 0.21 0.14 enet 17 0.18 1.6e-12 -6.0 -5.7 1.0e-08 0.94 0.08 0.92 FALSE
42 GTEx Nerve Tibial HSD3B7 0.09 0.05 lasso 3 0.03 2.4e-03 -6.2 -6.1 8.7e-10 0.95 0.04 0.83 FALSE
43 GTEx Nerve Tibial RP11-196G11.2 0.17 0.22 lasso 6 0.22 2.3e-15 -5.9 -6.2 6.5e-10 0.96 0.03 0.97 FALSE
44 GTEx Ovary RP11-196G11.2 0.41 0.22 lasso 10 0.25 6.0e-07 -6.0 -6.1 1.0e-09 0.93 0.06 0.94 FALSE
45 GTEx Pancreas STX1B 0.23 0.18 lasso 3 0.16 2.8e-07 -6.0 -6.0 2.1e-09 0.98 0.06 0.94 FALSE
46 GTEx Pancreas RP11-196G11.2 0.13 0.11 lasso 1 0.11 2.5e-05 -5.9 -5.9 3.4e-09 0.95 0.05 0.94 FALSE
47 GTEx Pituitary HSD3B7 0.13 0.07 lasso 7 0.05 2.1e-02 -6.2 -6.4 1.5e-10 0.90 0.04 0.89 FALSE
48 GTEx Pituitary RP11-196G11.2 0.21 0.28 lasso 6 0.23 1.4e-06 -6.0 -5.9 3.5e-09 0.94 0.04 0.94 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic HSD3B7 0.11 0.12 enet 6 0.10 5.9e-06 -6.2 -5.9 3.6e-09 0.93 0.03 0.97 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic KAT8 0.30 0.20 enet 15 0.26 1.9e-14 -4.7 -5.3 1.2e-07 0.83 0.35 0.65 FALSE
51 GTEx Skin Not Sun Exposed Suprapubic RP11-196G11.2 0.22 0.21 lasso 9 0.26 3.2e-14 -6.0 -6.1 1.3e-09 0.94 0.06 0.94 FALSE
52 GTEx Skin Sun Exposed Lower leg STX1B 0.05 0.04 enet 4 0.05 7.2e-05 -6.0 -6.1 8.0e-10 0.97 0.05 0.94 FALSE
53 GTEx Skin Sun Exposed Lower leg HSD3B7 0.12 0.17 lasso 5 0.16 2.7e-13 -5.9 -6.2 6.6e-10 0.92 0.04 0.96 FALSE
54 GTEx Skin Sun Exposed Lower leg KAT8 0.31 0.23 lasso 6 0.35 2.2e-30 4.3 -5.3 1.2e-07 0.82 1.00 0.00 FALSE
55 GTEx Skin Sun Exposed Lower leg RP11-196G11.2 0.16 0.15 lasso 7 0.15 4.0e-12 -6.0 -6.2 6.3e-10 0.96 0.04 0.96 FALSE
56 GTEx Small Intestine Terminal Ileum RP11-196G11.2 0.18 0.07 enet 15 0.06 1.5e-02 -5.9 -5.4 8.1e-08 0.79 0.03 0.73 FALSE
57 GTEx Testis STX1B 0.26 0.23 lasso 5 0.25 1.2e-11 -6.2 -6.1 8.3e-10 0.93 0.04 0.96 FALSE
58 GTEx Testis STX4 0.15 0.02 lasso 6 0.01 8.2e-02 -6.4 -5.9 3.9e-09 0.96 0.03 0.83 FALSE
59 GTEx Testis RP11-196G11.2 0.14 0.11 lasso 4 0.13 3.1e-06 -5.9 -6.1 1.4e-09 0.96 0.04 0.96 FALSE
60 GTEx Thyroid STX4 0.06 0.02 lasso 6 0.03 1.4e-03 3.0 -5.4 5.7e-08 0.82 0.05 0.91 FALSE
61 GTEx Thyroid RP11-196G11.2 0.11 0.14 lasso 2 0.14 3.5e-11 -6.2 -6.1 8.6e-10 0.96 0.05 0.95 FALSE
62 GTEx Uterus RP11-196G11.2 0.18 0.16 lasso 20 0.15 5.4e-04 -6.0 -6.1 1.3e-09 0.95 0.04 0.92 FALSE
63 GTEx Whole Blood RP11-196G11.2 0.07 0.05 lasso 3 0.06 1.4e-06 -5.9 -5.3 1.2e-07 0.89 0.06 0.93 FALSE
64 METSIM Adipose RP11-196G11.2 0.13 0.17 lasso 9 0.16 2.2e-23 -6.3 -6.3 3.1e-10 1.00 0.02 0.98 FALSE
65 ROSMAP Brain Pre-frontal Cortex STX1B 0.08 0.10 lasso 7 0.10 3.0e-12 -6.3 -6.2 4.3e-10 0.90 0.03 0.97 FALSE
66 ROSMAP Brain Pre-frontal Cortex HSD3B7 0.03 0.05 lasso 6 0.02 3.0e-04 -6.2 -6.1 8.3e-10 0.94 0.03 0.97 FALSE
67 ROSMAP Brain Pre-frontal Cortex SETD1A 0.02 0.01 blup 232 0.02 4.3e-04 -3.7 -5.4 8.0e-08 0.86 0.08 0.81 FALSE
68 ROSMAP Brain Pre-frontal Cortex STX4 0.06 0.11 lasso 10 0.11 1.4e-13 -6.2 6.2 5.4e-10 -0.94 0.04 0.96 FALSE
69 ROSMAP Brain Pre-frontal Cortex PRSS36 0.14 0.12 bslmm 241 0.12 1.1e-15 -4.8 -5.3 9.8e-08 0.75 0.99 0.01 FALSE
70 ROSMAP Brain Pre-frontal Cortex RP11-196G11.2 0.12 0.12 lasso 4 0.12 1.1e-14 -6.3 -6.3 3.0e-10 1.00 0.02 0.98 FALSE
71 YFS Blood STX4 0.03 0.06 lasso 2 0.05 4.3e-17 -6.3 -6.3 3.8e-10 0.98 0.02 0.98 FALSE
72 YFS Blood ZNF646 0.03 0.01 enet 17 0.02 3.9e-07 3.0 -5.2 1.8e-07 0.67 0.28 0.72 FALSE
73 The Cancer Genome Atlas Bladder Urothelial Carcinoma HSD3B7 0.04 0.02 enet 13 0.03 2.1e-03 -6.4 -6.2 4.4e-10 0.85 0.01 0.71 FALSE
74 The Cancer Genome Atlas Bladder Urothelial Carcinoma MYST1 0.04 0.03 enet 4 0.03 1.2e-03 -4.8 -5.2 2.0e-07 0.82 0.04 0.72 FALSE
75 The Cancer Genome Atlas Breast Invasive Carcinoma HSD3B7 0.03 0.03 blup 31 0.04 5.2e-08 -6.3 -6.1 1.3e-09 0.92 0.02 0.98 FALSE
76 The Cancer Genome Atlas Breast Invasive Carcinoma MYST1 0.05 0.04 blup 34 0.08 2.1e-15 -4.7 -5.9 3.8e-09 0.89 0.02 0.98 FALSE
77 The Cancer Genome Atlas Breast Invasive Carcinoma PRSS53 0.03 0.03 blup 38 0.02 6.8e-06 -5.9 6.0 1.9e-09 -0.96 0.02 0.98 FALSE
78 The Cancer Genome Atlas Glioblastoma Multiforme MYST1 0.18 0.07 blup 35 0.11 4.2e-04 3.8 -5.4 5.2e-08 0.78 0.05 0.68 FALSE
79 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BCL7C 0.04 0.01 blup 29 0.02 6.9e-03 -6.0 6.0 1.4e-09 -0.79 0.01 0.84 FALSE
80 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HSD3B7 0.06 0.01 blup 31 0.02 7.4e-04 -6.4 -5.2 1.8e-07 0.82 0.02 0.91 FALSE
81 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MYST1 0.08 0.04 blup 34 0.07 7.2e-08 4.3 -6.4 1.9e-10 0.91 0.01 0.99 FALSE
82 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma HSD3B7 0.14 0.14 lasso 5 0.15 6.1e-09 -5.7 -5.4 5.8e-08 0.87 0.02 0.98 FALSE
83 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF668 0.02 0.01 enet 8 0.02 3.1e-03 3.8 5.5 3.4e-08 -0.83 0.02 0.71 FALSE
84 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HSD3B7 0.08 0.05 blup 31 0.05 1.8e-03 -5.7 -6.1 1.4e-09 0.90 0.02 0.95 FALSE
85 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MYST1 0.08 0.08 enet 8 0.08 2.8e-09 -4.8 -5.2 2.1e-07 0.85 0.52 0.48 FALSE
86 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HSD3B7 0.04 0.04 blup 31 0.05 3.6e-04 -6.2 -6.0 1.6e-09 0.92 0.02 0.86 FALSE
87 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma STX1B 0.02 0.01 blup 32 0.01 5.5e-02 -6.0 -6.3 3.8e-10 0.93 0.02 0.58 FALSE
88 The Cancer Genome Atlas Pancreatic Adenocarcinoma MYST1 0.22 0.15 blup 36 0.21 2.1e-09 4.3 -5.5 3.7e-08 0.83 0.15 0.84 FALSE
89 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HSD3B7 0.09 0.12 blup 31 0.11 4.1e-05 -6.4 -6.3 2.4e-10 0.92 0.02 0.96 FALSE
90 The Cancer Genome Atlas Prostate Adenocarcinoma HSD3B7 0.24 0.27 lasso 6 0.26 2.0e-27 -5.7 -5.9 3.5e-09 0.89 0.02 0.98 FALSE
91 The Cancer Genome Atlas Prostate Adenocarcinoma PRSS36 0.17 0.13 blup 27 0.14 1.0e-14 -4.7 -5.5 4.4e-08 0.76 0.81 0.19 FALSE
92 The Cancer Genome Atlas Prostate Adenocarcinoma PRSS53 0.06 0.02 enet 7 0.04 4.7e-05 -5.9 6.0 2.1e-09 -0.96 0.01 0.99 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma STX1B 0.04 0.03 blup 32 0.04 9.5e-05 -6.4 -6.0 1.5e-09 0.91 0.02 0.98 FALSE
94 The Cancer Genome Atlas Stomach Adenocarcinoma MYST1 0.04 0.02 blup 35 0.02 8.7e-03 -4.8 -5.7 1.6e-08 0.86 0.02 0.43 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma HSD3B7 0.20 0.27 lasso 12 0.28 1.8e-27 -6.4 -6.4 1.9e-10 0.90 0.02 0.98 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma MYST1 0.12 0.10 lasso 3 0.14 1.1e-13 4.3 -5.2 1.5e-07 0.79 0.51 0.49 FALSE
97 The Cancer Genome Atlas Thyroid Carcinoma PRSS53 0.11 0.04 enet 8 0.05 9.7e-06 -6.3 5.6 1.8e-08 -0.88 0.01 0.98 FALSE