[Hub]/) : Traits : Neuroticism (Nagel 2018) : ← →

chr16:30,347,731-31,860,399

Best TWAS P=3.33e-11 · Best GWAS P=8.87e-11 conditioned to 0.166

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSD3B7	0.05	0.06	lasso	4	0.07	5.5e-09	-6.3	-6.3	3.1e-10	1.00	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	-4.8	-5.7	1.0e-08	0.88	0.10	0.90	FALSE
3	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	-6.0	-6.2	6.5e-10	0.96	0.11	0.89	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-196G11.2	0.08	0.07	enet	16	0.08	8.4e-05	-6.4	-5.8	7.0e-09	0.92	0.03	0.96	FALSE
5	GTEx	Adrenal Gland	HSD3B7	0.21	0.17	lasso	4	0.13	2.9e-05	-6.2	-5.6	2.3e-08	0.93	0.04	0.91	FALSE
6	GTEx	Artery Aorta	STX1B	0.17	0.18	lasso	6	0.15	1.9e-08	-6.4	-6.3	2.2e-10	0.98	0.02	0.98	FALSE
7	GTEx	Artery Aorta	RP11-196G11.2	0.10	0.16	lasso	2	0.14	7.1e-08	-5.9	-6.1	1.2e-09	0.95	0.04	0.96	FALSE
8	GTEx	Artery Coronary	RP11-196G11.2	0.12	0.06	lasso	6	0.06	3.4e-03	-6.0	-6.0	1.7e-09	0.93	0.04	0.88	FALSE
9	GTEx	Artery Tibial	RP11-196G11.2	0.08	0.04	lasso	4	0.03	3.8e-03	-5.9	-5.8	8.8e-09	0.94	0.04	0.95	FALSE
10	GTEx	Brain Cerebellar Hemisphere	STX1B	0.13	0.11	lasso	5	0.10	1.5e-03	-6.2	-6.3	3.0e-10	0.93	0.03	0.76	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-196G11.2	0.18	0.06	lasso	6	0.10	1.7e-03	-6.3	-5.8	4.8e-09	0.97	0.03	0.89	FALSE
12	GTEx	Brain Cerebellum	STX1B	0.24	0.16	lasso	11	0.18	4.8e-06	-6.0	-6.0	2.5e-09	0.94	0.04	0.96	FALSE
13	GTEx	Brain Cerebellum	STX4	0.14	0.25	lasso	1	0.24	8.3e-08	-6.2	-6.2	5.8e-10	0.94	0.05	0.94	FALSE
14	GTEx	Brain Cerebellum	RP11-196G11.2	0.31	0.30	lasso	4	0.36	1.3e-11	-6.2	-6.2	6.2e-10	0.96	0.06	0.94	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	STX4	0.19	0.11	enet	14	0.09	2.6e-03	-5.9	5.5	4.0e-08	-0.85	0.04	0.72	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	4.2	-5.2	2.2e-07	0.79	0.15	0.08	FALSE
17	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	4.3	-5.6	2.4e-08	0.82	0.16	0.84	FALSE
18	GTEx	Breast Mammary Tissue	RP11-196G11.2	0.13	0.16	lasso	4	0.17	5.0e-09	-6.0	-5.7	1.1e-08	0.97	0.08	0.92	FALSE
19	GTEx	Breast Mammary Tissue (Male)	RP11-196G11.2	0.15	0.16	lasso	4	0.09	3.9e-03	-6.0	-6.0	1.9e-09	0.98	0.04	0.90	FALSE
20	GTEx	Cells Transformed fibroblasts	STX1B	0.12	0.10	lasso	5	0.10	6.8e-08	-5.9	-5.5	4.7e-08	0.93	0.03	0.97	FALSE
21	GTEx	Cells Transformed fibroblasts	HSD3B7	0.11	0.07	lasso	8	0.06	1.4e-05	-6.2	-5.4	7.2e-08	0.90	0.04	0.95	FALSE
22	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	-6.3	-6.3	2.7e-10	0.98	0.02	0.98	FALSE
23	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	4.3	-5.1	2.9e-07	0.80	0.27	0.14	FALSE
24	GTEx	Colon Transverse	HSD3B7	0.16	0.15	enet	20	0.19	2.1e-09	-6.1	-5.4	6.6e-08	0.89	0.04	0.96	FALSE
25	GTEx	Colon Transverse	STX4	0.10	0.09	lasso	3	0.06	6.6e-04	-6.0	-6.0	2.1e-09	0.98	0.03	0.92	FALSE
26	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	-5.9	-6.1	1.2e-09	0.94	0.03	0.97	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-4.8	-5.6	2.0e-08	0.88	0.05	0.94	FALSE
28	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	-6.2	-6.1	8.9e-10	0.86	0.04	0.95	FALSE
29	GTEx	Esophagus Mucosa	HSD3B7	0.38	0.32	lasso	5	0.36	1.2e-24	-6.2	-5.8	7.9e-09	0.93	0.04	0.96	FALSE
30	GTEx	Esophagus Mucosa	STX4	0.08	0.00	enet	21	0.02	1.0e-02	-5.9	-5.5	3.7e-08	0.78	0.06	0.90	FALSE
31	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	-4.8	-5.2	1.7e-07	0.82	0.94	0.06	FALSE
32	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	-6.0	-6.1	8.7e-10	0.91	0.04	0.94	FALSE
33	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	-5.9	-6.2	6.9e-10	0.97	0.03	0.94	FALSE
34	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	-4.8	-5.3	1.2e-07	0.82	0.86	0.14	FALSE
35	GTEx	Esophagus Muscularis	RP11-196G11.2	0.14	0.14	lasso	6	0.13	3.7e-08	-6.0	-6.0	1.7e-09	0.96	0.03	0.97	FALSE
36	GTEx	Heart Left Ventricle	HSD3B7	0.12	0.08	lasso	3	0.07	2.0e-04	-6.1	-6.1	8.6e-10	0.94	0.04	0.94	FALSE
37	GTEx	Lung	RP11-196G11.2	0.21	0.12	enet	22	0.14	1.6e-10	-6.2	-6.6	3.3e-11	0.88	0.08	0.92	TRUE
38	GTEx	Muscle Skeletal	HSD3B7	0.15	0.13	enet	19	0.14	5.5e-14	-6.2	-5.1	2.8e-07	0.89	0.04	0.96	FALSE
39	GTEx	Muscle Skeletal	STX4	0.04	0.04	lasso	3	0.03	2.9e-04	-6.4	-6.3	2.1e-10	0.98	0.02	0.97	FALSE
40	GTEx	Muscle Skeletal	RP11-196G11.2	0.15	0.10	enet	10	0.12	1.0e-11	-6.0	-6.0	1.6e-09	0.95	0.03	0.97	FALSE
41	GTEx	Nerve Tibial	STX1B	0.21	0.14	enet	17	0.18	1.6e-12	-6.0	-5.7	1.0e-08	0.94	0.08	0.92	FALSE
42	GTEx	Nerve Tibial	HSD3B7	0.09	0.05	lasso	3	0.03	2.4e-03	-6.2	-6.1	8.7e-10	0.95	0.04	0.83	FALSE
43	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	-5.9	-6.2	6.5e-10	0.96	0.03	0.97	FALSE
44	GTEx	Ovary	RP11-196G11.2	0.41	0.22	lasso	10	0.25	6.0e-07	-6.0	-6.1	1.0e-09	0.93	0.06	0.94	FALSE
45	GTEx	Pancreas	STX1B	0.23	0.18	lasso	3	0.16	2.8e-07	-6.0	-6.0	2.1e-09	0.98	0.06	0.94	FALSE
46	GTEx	Pancreas	RP11-196G11.2	0.13	0.11	lasso	1	0.11	2.5e-05	-5.9	-5.9	3.4e-09	0.95	0.05	0.94	FALSE
47	GTEx	Pituitary	HSD3B7	0.13	0.07	lasso	7	0.05	2.1e-02	-6.2	-6.4	1.5e-10	0.90	0.04	0.89	FALSE
48	GTEx	Pituitary	RP11-196G11.2	0.21	0.28	lasso	6	0.23	1.4e-06	-6.0	-5.9	3.5e-09	0.94	0.04	0.94	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	HSD3B7	0.11	0.12	enet	6	0.10	5.9e-06	-6.2	-5.9	3.6e-09	0.93	0.03	0.97	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	-4.7	-5.3	1.2e-07	0.83	0.35	0.65	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RP11-196G11.2	0.22	0.21	lasso	9	0.26	3.2e-14	-6.0	-6.1	1.3e-09	0.94	0.06	0.94	FALSE
52	GTEx	Skin Sun Exposed Lower leg	STX1B	0.05	0.04	enet	4	0.05	7.2e-05	-6.0	-6.1	8.0e-10	0.97	0.05	0.94	FALSE
53	GTEx	Skin Sun Exposed Lower leg	HSD3B7	0.12	0.17	lasso	5	0.16	2.7e-13	-5.9	-6.2	6.6e-10	0.92	0.04	0.96	FALSE
54	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	4.3	-5.3	1.2e-07	0.82	1.00	0.00	FALSE
55	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	-6.0	-6.2	6.3e-10	0.96	0.04	0.96	FALSE
56	GTEx	Small Intestine Terminal Ileum	RP11-196G11.2	0.18	0.07	enet	15	0.06	1.5e-02	-5.9	-5.4	8.1e-08	0.79	0.03	0.73	FALSE
57	GTEx	Testis	STX1B	0.26	0.23	lasso	5	0.25	1.2e-11	-6.2	-6.1	8.3e-10	0.93	0.04	0.96	FALSE
58	GTEx	Testis	STX4	0.15	0.02	lasso	6	0.01	8.2e-02	-6.4	-5.9	3.9e-09	0.96	0.03	0.83	FALSE
59	GTEx	Testis	RP11-196G11.2	0.14	0.11	lasso	4	0.13	3.1e-06	-5.9	-6.1	1.4e-09	0.96	0.04	0.96	FALSE
60	GTEx	Thyroid	STX4	0.06	0.02	lasso	6	0.03	1.4e-03	3.0	-5.4	5.7e-08	0.82	0.05	0.91	FALSE
61	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	-6.2	-6.1	8.6e-10	0.96	0.05	0.95	FALSE
62	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	-6.0	-6.1	1.3e-09	0.95	0.04	0.92	FALSE
63	GTEx	Whole Blood	RP11-196G11.2	0.07	0.05	lasso	3	0.06	1.4e-06	-5.9	-5.3	1.2e-07	0.89	0.06	0.93	FALSE
64	METSIM	Adipose	RP11-196G11.2	0.13	0.17	lasso	9	0.16	2.2e-23	-6.3	-6.3	3.1e-10	1.00	0.02	0.98	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	STX1B	0.08	0.10	lasso	7	0.10	3.0e-12	-6.3	-6.2	4.3e-10	0.90	0.03	0.97	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	-6.2	-6.1	8.3e-10	0.94	0.03	0.97	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	-3.7	-5.4	8.0e-08	0.86	0.08	0.81	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	STX4	0.06	0.11	lasso	10	0.11	1.4e-13	-6.2	6.2	5.4e-10	-0.94	0.04	0.96	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	PRSS36	0.14	0.12	bslmm	241	0.12	1.1e-15	-4.8	-5.3	9.8e-08	0.75	0.99	0.01	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	RP11-196G11.2	0.12	0.12	lasso	4	0.12	1.1e-14	-6.3	-6.3	3.0e-10	1.00	0.02	0.98	FALSE
71	YFS	Blood	STX4	0.03	0.06	lasso	2	0.05	4.3e-17	-6.3	-6.3	3.8e-10	0.98	0.02	0.98	FALSE
72	YFS	Blood	ZNF646	0.03	0.01	enet	17	0.02	3.9e-07	3.0	-5.2	1.8e-07	0.67	0.28	0.72	FALSE
73	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSD3B7	0.04	0.02	enet	13	0.03	2.1e-03	-6.4	-6.2	4.4e-10	0.85	0.01	0.71	FALSE
74	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	-4.8	-5.2	2.0e-07	0.82	0.04	0.72	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	-6.3	-6.1	1.3e-09	0.92	0.02	0.98	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	-4.7	-5.9	3.8e-09	0.89	0.02	0.98	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRSS53	0.03	0.03	blup	38	0.02	6.8e-06	-5.9	6.0	1.9e-09	-0.96	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	3.8	-5.4	5.2e-08	0.78	0.05	0.68	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCL7C	0.04	0.01	blup	29	0.02	6.9e-03	-6.0	6.0	1.4e-09	-0.79	0.01	0.84	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	-6.4	-5.2	1.8e-07	0.82	0.02	0.91	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYST1	0.08	0.04	blup	34	0.07	7.2e-08	4.3	-6.4	1.9e-10	0.91	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HSD3B7	0.14	0.14	lasso	5	0.15	6.1e-09	-5.7	-5.4	5.8e-08	0.87	0.02	0.98	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	3.8	5.5	3.4e-08	-0.83	0.02	0.71	FALSE
84	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD3B7	0.08	0.05	blup	31	0.05	1.8e-03	-5.7	-6.1	1.4e-09	0.90	0.02	0.95	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYST1	0.08	0.08	enet	8	0.08	2.8e-09	-4.8	-5.2	2.1e-07	0.85	0.52	0.48	FALSE
86	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	-6.2	-6.0	1.6e-09	0.92	0.02	0.86	FALSE
87	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	-6.0	-6.3	3.8e-10	0.93	0.02	0.58	FALSE
88	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	4.3	-5.5	3.7e-08	0.83	0.15	0.84	FALSE
89	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	-6.4	-6.3	2.4e-10	0.92	0.02	0.96	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD3B7	0.24	0.27	lasso	6	0.26	2.0e-27	-5.7	-5.9	3.5e-09	0.89	0.02	0.98	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS36	0.17	0.13	blup	27	0.14	1.0e-14	-4.7	-5.5	4.4e-08	0.76	0.81	0.19	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS53	0.06	0.02	enet	7	0.04	4.7e-05	-5.9	6.0	2.1e-09	-0.96	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	STX1B	0.04	0.03	blup	32	0.04	9.5e-05	-6.4	-6.0	1.5e-09	0.91	0.02	0.98	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	-4.8	-5.7	1.6e-08	0.86	0.02	0.43	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	HSD3B7	0.20	0.27	lasso	12	0.28	1.8e-27	-6.4	-6.4	1.9e-10	0.90	0.02	0.98	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	4.3	-5.2	1.5e-07	0.79	0.51	0.49	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	PRSS53	0.11	0.04	enet	8	0.05	9.7e-06	-6.3	5.6	1.8e-08	-0.88	0.01	0.98	FALSE